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<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW84</accession>
    <name>G3AW84_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta transducin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101143</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
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            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGV66480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="590646.G3AW84"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0034388">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0032040">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030515">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
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    </dbReference>
    <dbReference type="Pfam" id="PF25173">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
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    <feature type="repeat" description="WD" evidence="6">
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        </location>
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    <feature type="repeat" description="WD" evidence="6">
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    <feature type="repeat" description="WD" evidence="6">
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        </location>
    </feature>
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        <location>
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    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="818"/>
            <end position="924"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
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    </evidence>
    <sequence length="957" mass="107582" checksum="5A1932375E35A905" modified="2011-11-16" version="1">MVKSYDRYEQETCFGVITSQSNIVWLPPIDSQSKKSAGRALTSGVEEILVWDIKTGEKLQTLSDGLTPGASNAPTSQPPSSVSYLAYHATSNIVASGYNDGTIKVWDLASASVIIKFQGHKSRISKLKFDTSGTRLVSGSNDASIILWDLVGEEGLFKLKGHKGEVTDLTFLSQGKKEVDELDDYIVSVSKDGLVKLWELESKQCVETHIAHSNECWSLAVNYDSNMLITSGNKDQVKVWDIDLANEDMKKIQERGMFAKQSKARCNQMEFEQILKGGEVNQIFYLQNTDRTVEMFRVRTDAELQKGVKSRTKRLKEKGMSEEEIVENIRENEINMLITPFTTLRTIHKIKSCSWFKAGKKLKVLVSLVNNAVELYTVQMPENLKKNQEVVIDRSNTIELLGHRNDIRSIDISSDDQLLVTASNGELKVWNLKTFNVLRNFQLSSGYALCCKFLPGGSLVVIGYKNGDLELYDLSSSSLVDKVEQAHKGDESNDEGSAIWCLDLSPDGKTLITGGNDKSVKFWDLQLVTETVPGTKEVVTKLKFNHKQTLEMTDEVLAVKVSSHGKLLAISLLNNNVQVVYLDTLKLFLTLYGHKLPVLSIDISSDSKLIITSSADKNIKIWGLDFGDCHKSIFGHQDSIMNVKFIGDSHNFFSSGKDGLIKYWDGDKFECIQKLVAHQSEVWSLSVSHSGLFMVSASHDHSLRLWSATNDQVFLEEEREKEIDELYEDTLLTSLEGEEPVTEEGDDSDEVTKVTKQTMESLKAGEKLIEAIDIGYEDLNNQVQYHQALAQYQKQPHGVKPTKPESHTILMAYGMSGEQHVFKTVTSIRSAQLEDALLVLPFSYTKKLLAFIEVWMQKLNNLNQISVVCKVLNFLVKNNLKELVHQKDSDLKSQLVTIKTHLRQSLEGSSHKINFNLQGMKFVRTQWNLQHQAQYIDQAEQAAAEDSRAIKRSFVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW85</accession>
    <name>G3AW85_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_128887</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="1938591at2759"/>
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        </location>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="332" mass="35400" checksum="DF6DB3CBA465298D" modified="2011-11-16" version="1">MNMGQSQWSGPTGQPQGIPQTQPLSAPTVSQPVINSPMMNNPSSSPIMGQSASANANARAKGKRASTSSQAGRKKSTKGGAPTPGASATTPASLANAIRTPNSIPTPQVPTSQSNKNTPGDNNQSPNFQNKISGGKLNEHAIGDIFSSIDENESQVFELNKRKEMSDQDPEKFFFASLANLVEFDDSSDLKGLPTPSPSVNGKSSISSIKSLNGNSTLRTPSSPSTEWTATIKPEAIVTSFKQVSSIKEAVSMEILDVCAEIAGGVAGTDKSSGLLNGLGLKREREEEEDDLDFLFTEEKKFKPESDDTFNFLYSENLDFNQWKSHIISQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
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    <name>G3AWM5_CANTC</name>
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        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="9">
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        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
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            <taxon>Saccharomycotina</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
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        </cofactor>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000029">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF9">
        <property type="entry name" value="OBG-LIKE ATPASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="34"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="310"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46223" checksum="41CB942DC4137111" modified="2011-11-16" version="1">MNHVRLFTTTWVRFKPKVSDIDFNRLPSRNSNNLSSGVVGLANVGKSTFFQAITKTKLGNPANYPFATIEPEESKILVQSTRLDKLSKLYGSKKKIPTSLKIFDIAGLTRNASNGEGLGNKFLEDIRQVDGIFQIVRGFRDDSIIHIENNVDPVRDLVIVMDELILKDLEFVESGIDKLEKTIKKPNQPIDKMKKELKLLEEFQEMLYEGKKIGTFKFKDIESVEMTRKYNFLTIKPTVYLLNVNKEDYLRNDTEFKKDIEVWLQENCPNDKLMLICAQYENDKLDNPQEEDTESNRLNGVVEEMRDSLSLISYFTCGPQEAREWTIKRGTGAADAAAVIHNDLKDSFIAAQVYKYSDVIKLAEKNEKVNESELKAKGLQYRYGKDHVVEDGDIILFKSAKGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX05</accession>
    <name>G3AX05_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_100837</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX05"/>
    <dbReference type="STRING" id="590646.G3AX05"/>
    <dbReference type="GeneID" id="18245413"/>
    <dbReference type="KEGG" id="cten:18245413"/>
    <dbReference type="eggNOG" id="KOG4657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085127_0_0_1"/>
    <dbReference type="OrthoDB" id="4025436at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="13">
        <location>
            <begin position="159"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="231" mass="27104" checksum="F7A4F364F3D9B890" modified="2011-11-16" version="1">MSAQQITSPIEEFFQLQKDLDGFTSRFTKEISSKKRQIIDDKTSFNIKVNDLKSEEVRLTSQINQLDGHRSELQRKIEESIINFEDRRAKIDELHAEETKLNTKKLELDEELNGINNQINEINNKIEKLSKNLEDQVVQDDVELVKFERYLGLRIEVLKEDLMKFRFSNLDASNLDKEFWIDLNIAEEFQITGSFPAMGEDEMAPILVEFNQSQNFGRFLKQIRQVLKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX68</accession>
    <name>G3AX68_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_132957</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX68"/>
    <dbReference type="STRING" id="590646.G3AX68"/>
    <dbReference type="eggNOG" id="ENOG502RYUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032841_0_0_1"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="2">
        <location>
            <begin position="119"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="540" mass="60714" checksum="EC38C2E2C19B029A" modified="2011-11-16" version="1">MTDTKKMASDSPAPAAPDLSYPKTVGASVPKASPTTSTSTRFYSLIERDNVKKIKSKRLQEVLRLDPVADTEEFKFLCKIYLPKRFQLNGDSGQQMKQLSAALPTFLPHSNDTTNISYPKLNFELHMFLSSIMVNYVTSWYLRKLNTDNMDFVQVVYSTLCEFIRDFAMRCSIILNSENLLDSIDDWSAILNDHIEGLVGENTIRIVEQQGGLPVVSEPTGDRTIIDQYLASQHVIFASDASKQKYFRVLVKNLLSTTFSSADDNLGPLNTQIGMNFVDIVVADLVLGKILNKLSTPDFCLSVISRIVGAVKAKLDDRLSSVKTTSQPKSIREKIKNSFSRSYKDVGYLTFWNDEGVDTDHNILENSVFRLLNTLTGFSDRKPLFAAIVSTVRSVIMSHSALSTKVNRIFKKYLFKGIVKSRLIHDDTLSKVISSLRTSVFNDDNPPVPQVELSATTIANDIYDLLTHKALPGNLFSYFKYKGESKTDTLHSIECTLRVFMAPVDSETNVPSTLNQWLWVKIIDNLVAKMYPELVEETQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXA2</accession>
    <name>G3AXA2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_96397</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXA2"/>
    <dbReference type="STRING" id="590646.G3AXA2"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="564" mass="61215" checksum="BE22518B15D403DA" modified="2011-11-16" version="1">MSRDIDKNPTLVDFKKTNVESEEVCLLSEPSSAYDAADNVNGNEDQNGGYALPRHKLRIVVSSLYICAYLAALDATVVSTLLSVIASDLNSFGNMSWIATAYLLSCSALQPIHGRLSDIFGRKILLIGCAVFFALGCLICMAHSMTFVVIGRFIAGIGGSGLTTLTTIILSDLIPLRDRGVYQGYTNSFYGLGVATGGIFGGVINDYFGWRYAFGLQVPLACILGVSLYFNLQFPKGSPGLGSPGHFKEKLAKVDFLGSTLLVSGLLVLLTAASIGGKEVAYSSKPFIGLCLASVFLFGTFVWAESHTPLQPIIPISLLRRRTILASSMTNWFYTMGVFTYLFYVPIYYISVMDYNTTKIGMRLIPNFFGTSLGSVGAGIYMKRTGRYYNLIIVIGVLAIVGNLNILSINPTISNLRQFTLLLPCGLAYSGILTATLMSLIAAVPASHQAGTTSISYTFRATGSTLGVSISSAIFQYSLRSMLNSKIPSIVNDQVMSDYIIKHALQSTSYASKAPEYVQVALRCCYEYAVKKTLLFSFICVVIGVFASLFIQEHELHTSINRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXH6</accession>
    <name>G3AXH6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_100566</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683640.1">
        <property type="nucleotide sequence ID" value="XM_006683577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXH6"/>
    <dbReference type="GeneID" id="18245395"/>
    <dbReference type="KEGG" id="cten:18245395"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="505" mass="56778" checksum="0BBFB2F442A26A19" modified="2011-11-16" version="1">MSESADTASGEKVFADIKVDSLGEVNDGDLDAGAKYLIDHPQYADYTPEEARKLLWKIDLMLIPMMTIIITLAAADKIVISNAAVYGMTADLKLVGNKYSWVGSIFYFGYLIMELPANLLIQKLPVRKTLFTSFVIWNIILMCMGAAQNFSQLAAMRFLLGMGETFLFPSCSVITAMFYKKSEQPFRTAIWFSGFSSIITGILSYAVGHANTKLANWRLLFITFASITLFFTAALYVVLPDSPMSCWWMNDREKYIAIHRTKENRTGTKNTNFKRYQIMEALKDWKTWVLAVFALCNNISNGALVTFAGQIVSGLGYSPLRTTLLGMPTGVFMTASSWMIALPTFFYPKKFRTVSAFTICLVPLICCVLMMKLDGKISLLIAYYFFYFYWGPYVCMTAICFANTAGHTKKSVVNAVNFTSYCVANIIAPQFFISSEAPGYKTGYHAILGFTSGSLVSIATYGFGCYMENKKRDEKYGPAEDNVDLDLDALDLTDKEKEKWFRYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXM2</accession>
    <name>G3AXM2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_129128</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXM2"/>
    <dbReference type="STRING" id="590646.G3AXM2"/>
    <dbReference type="GeneID" id="18249364"/>
    <dbReference type="KEGG" id="cten:18249364"/>
    <dbReference type="eggNOG" id="KOG2005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="6">
        <location>
            <begin position="46"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="7">
        <location>
            <begin position="900"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="959" mass="105705" checksum="A7EBA064EB41F768" modified="2011-11-16" version="1">MNTKLCRSKFSQDRSMQQTEGKCGTKPSFKPYQELNEEDQHLKDELEMLVEKLNEPSHSEAEYVEYLDSLKSFIENSTTSLTAVPKPLKFLRPHYSLLCSVYESWSSKPSNLQDKFADVLSVLAMTYSDDGNNESLKYRLLCKHSIITDWGHEYMRHLALEIGSSYQESLGNDEEYVAKVVKLSTVIVQYFLKHNAEADAVDLLLEIEGIEKLPQYVDESTFQRVCLYMVSCVPYLSPPDDATFLQTAYSIYVTHNQLTQALALAIKLDDEELISQVFKSTEDVLVHKQLGLILSQQNNGFKYPGDDEQVQECIANVKLNDYFSYLVKELNLLDARVPEDVYKSHLETSKAGIGNSGSIDSAKQNLAASFVNMFLNLGFGNDKLVQTDEDNKSWIYKTKGPGMSSTTASLGAIHQWNVNDGLQILDKYTYSQQDEVKAGALLGTGIISANVHDDVDASLALLQDYVVDPSSSKVLQTSAINGLGIAFAGTANEEVLALLLPLVSDLDISVEVSSLSALALGHVFVGTCNGDITSTILQTLLERDFTQLTNKFITLMALGLGLLYMGKTEQVEDVLGTIDAIEHPISKTLKVLVNICAYAGTGNVLQIQSLLQMCTSRPKEETDVSGEDENEAEADATAPVANSTTANIDEGNTEDVAMEDASPKPEKSEAVADDEADEEDDLDQDEEDVMYHGFAVLGLALIAMGEDIGQDMSLRHFSHLMHYGNSLIRRAVPLAMALTSTANPQMKVFETLSRYSHDPDLEVAQNAIYAMGLVGTGTNNARLAQLLRQLASYYIKSPDSLFMVRIAQGLLHLGKGTLTLSPFNVERSIISKVSVASLLTISVLMLNPKSFILSDSTTETTHQLLYYLIPAVKPRMLITVDEELNPLKVNVRVGQAVDVVGQAGKPKTITGWVTQSTPVLLNHGERAELENTDEWISLSHSLEGVVILKKNPEFMEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXU9</accession>
    <name>G3AXU9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112564</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXU9"/>
    <dbReference type="GeneID" id="18246583"/>
    <dbReference type="KEGG" id="cten:18246583"/>
    <dbReference type="eggNOG" id="ENOG502S645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050083_0_0_1"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45989" checksum="914DEEDA73F9BA82" modified="2011-11-16" version="1">MNQVQRLGFWSLPATKKQFVSETQSSQVLASLWCKFEPDRVEINAATTLPQPIKSKPQIYEQVSHDNPTASGVSLAWKRFYAYGKSIGGFYRAGVVNVWKNNSECNRLKKQFMMSDKVDHAGQSVALRIPRFNMLTHEMAQVIYMNRIENKTSNDISNVETKLIKHNQRPQDFDPGLFALTRSQYQLLNRTRKDFVKLPLFAVLFAIFVECTPLLCYAFPQITPSTCVLPSIVPRLWDTRGIEANSSLVSKELESGADLSSLASRTAYNMPAEQVKNMVRSLRLVSQYLPIGLYSDTTLRDRLQAHLNYLVVDNYYLCGLNRQGNIWDLSFEELVMACLERNLIEDLRLIYSEDRGVVSADLRARLARFLVDFKDYNIGYLTVRAHLSSIDSEKLIEWNSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY18</accession>
    <name>G3AY18_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tubulin binding cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92076</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY18"/>
    <dbReference type="STRING" id="590646.G3AY18"/>
    <dbReference type="GeneID" id="18250153"/>
    <dbReference type="KEGG" id="cten:18250153"/>
    <dbReference type="eggNOG" id="ENOG502T1DX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299545_0_0_1"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin binding cofactor C-like" evidence="1">
        <location>
            <begin position="77"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="212" mass="23993" checksum="D67872B44E971099" modified="2011-11-16" version="1">MTNYDKQKTRELINSLSRLLEAKKSSMDTSKFKFKGAPIILQTDNSPTKNLNIQVGPKPYMENIFDQRIEIQSPVNHLLLKQFERCIVLNHKNSSSVNLQTGANSILRFDIDGTISATGLTNCIVLANCHQLRLHNITNSLVVSDITTNVIMENCMNVKFSGAVNVDDFNFNFTNSQNYSYVEIERESLDWINGQYDADLLQQTLGLIHDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYB2</accession>
    <name>G3AYB2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_133230</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYB2"/>
    <dbReference type="STRING" id="590646.G3AYB2"/>
    <dbReference type="GeneID" id="18249680"/>
    <dbReference type="KEGG" id="cten:18249680"/>
    <dbReference type="eggNOG" id="KOG2014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_4_1_1"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="14"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="343" mass="38784" checksum="BE6DC5A1C4E1368C" modified="2011-11-16" version="1">MTSEELSRDEIALYDRQIRLWGIATQLRLRSARLLLINLGSVGMEAVKNLVLGGVNSIELMDNSTIKSEDYGAQFFLPKDDSKIGELKLPNVVDSIKELNDRVEININTKSFDTVIQGDPSYFKKFDLIIATEIQKPDTFKLNELTRELNLPLYIAGTHGMFGYIITDLIDNINETEKDMGNQPRKANTKLNLNKTIIKVESNESTNKELITIHDSYRPIKEIFSSKLLPEQLNKRQLKRLSPSLPLIFALFELQRVSDINAETLKSHALKACEELGVNPDIITDEYLKLFVDQGFTEFAPTSAILGGCLAQDIIQFLSKKESPINNVLIFDGLRSEMPIYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYC0</accession>
    <name>G3AYC0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_112679</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYC0"/>
    <dbReference type="eggNOG" id="ENOG502SBKC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1518435_0_0_1"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="114"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="204" mass="23610" checksum="C69434A3EABA9BAA" modified="2011-11-16" version="1">MSGSVSPTVESIPSQSHTPVPSNRTVQPIVLTLREMPSDLSVLPAGIIDKLTQQHSIFLGFIKSQPQLQEYNSDTMAFLDSQIHTINQVIELVEEYTQTSERINELIKTIKNVYTEFTDLEMIQYKLLAENFNQDSLKAKFRKVIAAEDQESKAFIKEYTNQDTQVNSSRLDEMLESFKKSRKKYHLRSEKMNRWNEERVTGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYI2</accession>
    <name>G3AYI2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_133279</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BMT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYI2"/>
    <dbReference type="STRING" id="590646.G3AYI2"/>
    <dbReference type="GeneID" id="18249686"/>
    <dbReference type="KEGG" id="cten:18249686"/>
    <dbReference type="eggNOG" id="ENOG502QTZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013841_1_1_1"/>
    <dbReference type="OrthoDB" id="3631276at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021988">
        <property type="entry name" value="BMT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12141">
        <property type="entry name" value="BMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="693" mass="79042" checksum="BEA345E2E8A9A839" modified="2011-11-16" version="1">MFVTRLDNRKLLLLCTAVLVTLLTSGSYFALKNSFSIADAQEHYPPGKTHDPGKDGGIVGSSKGGSTLGDTQTSPPDQTLKLQISKISDFDTDNKIVLFPKKFPLTDDQLKDFYSNRLAGSKLSETVQIARFNNNRREDDTTKSNAVDYISMKPESYHGHKITVFDSRADINGDTAKCDEIKRELSVDITDSKLLKTDLESILRTFQDGKSPYYKEMEPYFKAELEKQLQEHTINKYWYRLAGTSVWLSEYGVHMMISRVIYSPKGSRNQPRISLTYCQVFNEKWQELKDVELVVPSNDPENIFSQVDLDGTFFTKVKYPGFLAVPTYQNPDMTDHRFYGPEDPRLMVIQNEHGYEEPLMVYNSYHRKIIEQQFDGETKVVAKLGYYRSMFLCFPWQFQRGKRTIEELPDIKSDGRIYNRAIELRRKGMERLEVQKNWTPFIDFGERQAFRHDKHIYFVYRWSNLEVLRCEITGAVGTTSKCEFVYRMDDGLDAETPVGPVRGGTEMININSFSSEYDLGDILSFPEDSEVWIGFARAHLQDCGCGEHLYRPNFVVLMKDSKSGFYKINTISSFVSLDVPSIGWNLDKPDELCVEGRANVFIPNGISSLSVKQSKDGSFEDYLTLSFSLSDATVNVIHIRNILKSVLGSLVNNNHGYSNDNVDCAIIGSNQFCHDLGESVKVTKAQNSIKNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ42</accession>
    <name>G3AZ42_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin Pom152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_101861</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684577.1">
        <property type="nucleotide sequence ID" value="XM_006684514.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AZ42"/>
    <dbReference type="GeneID" id="18245507"/>
    <dbReference type="KEGG" id="cten:18245507"/>
    <dbReference type="eggNOG" id="ENOG502QQ5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002415_0_0_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="3">
        <location>
            <begin position="43"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="5">
        <location>
            <begin position="188"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="549"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="773"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="903"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="6">
        <location>
            <begin position="1108"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1297" mass="146652" checksum="5F324D72A0A71F11" modified="2011-11-16" version="1">MERSGKKRVRIDDTVTEIRSARQYSPPTNRQSNPLIPVHILDEAFQRILLVSVFVLIQAWKLYDAMLLNTIADDSVVGSSLSRMTFVLKYLLIDGLFLWFLPILNLQYLSFSPLVTLLFTLILNLFNILLASKLNMSLFMVVVGPYFKSLKPSKELTVAGDAINPKVIDMDSHFKGKYTIQYLPDSLAKFNVFDLHSVCQDPEEKIPFQIPIEFNTTTDLGLLEIQYTSPENKVSQIVFQESDLHKLINKDYSHLKSNKKYVKDDYRVFYLEIPVREPGSYKISIVRDKSGTNMRYVQNEFSFAYCPGASFILPKSYASDTNNKACVGFKLDDLSMKLPLITFYGSPPLVTKIGTTINGKSNKVIDAEISLETLDTLKFNFTSQFSHKITRNSLEQEILKDPKMFNVKESSTIQFQILEIKDSLGNVKRYNPQSDSSDLRYNLNLLTKPSLRLIDMDSSKKLLVNGTKDLSFATSSNIREQLPFTAYYAYESVINPELSFNFSHKFSTFADLQKGISVSNPGIYKLLRVSGKYCECEVQPSAINLETILPPSLEIQAEPLVDNCVGMTGYNFKFNAKGSAPFTVEYSVYQNSSSGTLRPLPGPNGRIKRLLKSSSNDFDFAYKPPGEGNYVVRFEAIRDYDYYDSPTLLNEKEHTYSTYFKQRSKVSFFDRQSNGLQKTINLCKGESTRVPVYFTGSFPFTFDYSLIDKNSGKNILTKLNQKAYSRLFEIDTKDITFGGIFDVVLANVVDANSCATDFDGKEKVQIVARSDVPEISFDVKQQVSYHKIVEGDFIDIPLSTRFFKSKSGTVEFEVSNLENLNDKRTETVQVSTHMTISKPGIYKLVSFTDGKCHGKISDIEKAIHVSFHPRPQIRADADKSITQSSSTNESLLLISGCQGCKRQATVHFEGKGPFMVDYEIKFPSGKTDSRTMTSDKSKLLIDLPTDNSGLYEHRFKRIFDGLYTRSKSPDRGFKPQIISYEVLPAPSIVFEKMDVLKLCEASLSKYINELDSLSISVSGKAPFSAQIMLIGDSLEKKFTIENINGPTINLNDAVDSKNVPIWKYLKQGEYELSITQVSDSNRCEKKTQNLSTLILSISPAPDVTKFDQSKSYYCVGDHVGYDLLGEPPFTLSYEFQGTYHKAQTTNEFRRLAAKPGIIHVSSMEDSSAGKCMVNIEPSSQKYKDLEIVIHDLPSVEVNHGDYISQNIHEGDQTELKFSFTGTPPFSITYVRTLDPNVKAKRTKNSKLHKGVNKIIETQTINNIKDHEYTVMVGLEGTYEAIEVKDKYCMAKREFSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ45</accession>
    <name>G3AZ45_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101610</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ45"/>
    <dbReference type="STRING" id="590646.G3AZ45"/>
    <dbReference type="GeneID" id="18245486"/>
    <dbReference type="KEGG" id="cten:18245486"/>
    <dbReference type="eggNOG" id="KOG0870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087036_0_0_1"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="227" mass="25201" checksum="9DEB704BF1350D50" modified="2011-11-16" version="1">MPPKGWRKNPDGSYPQPNREAEITSIDEILFPRSIIQRLAKDILNSNDANMSMAKDSLIALQRSATVFVSHVMFHARAISKASDRKTVNAQDILAALEAAEYSGFVPEIKHKLASFEAAVEVRKSEKAASRTEPADFNDVKRLKDNSENAVPVMDTTLEDDDHSDNGIEDNDNDNTEEVNDTNADEEDEIEEVSVPNPIAGVSQEATELEGVSMEEPEEENQQEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ97</accession>
    <name>G3AZ97_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_112903</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ97"/>
    <dbReference type="STRING" id="590646.G3AZ97"/>
    <dbReference type="GeneID" id="18246729"/>
    <dbReference type="KEGG" id="cten:18246729"/>
    <dbReference type="eggNOG" id="KOG2711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_2_3_1"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000294">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="211"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="294"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="369" mass="40479" checksum="0B3AEC297F5646AB" modified="2011-11-16" version="1">MTTTPIKIVTPFRIAIIGSGNWGTAVAKLVAENTRDKPEIFQKSVNMWVFEEDINGEKLTDIINTKHENVKYLPGIQLPENLIANPDVVDTVKNADLLVFNIPHQFLPRVCKQLVGQVKPSVRAISCLKGLEVTQEGCKLLSQSITDTLGIHCGVLSGANIANEVAKEKWSETSIAYDLPKDFKGDGLDINEYVLREAFHRSYFHVNVIKDVVGASIAGALKNVVAIAAGLVEGAGWGDNAKAAVMRIGIKETIKFASYYEKFGIKTSLPPQATTFTEESAGVADLITTCSGGRNVRVARYMVEHGVSAWEAEKTLLNGQSSQGILTAKEVHELLENYKLQDEFPLFEATYKVIYENLDVNELPTLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZE0</accession>
    <name>G3AZE0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112934</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit (SSU). Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZE0"/>
    <dbReference type="STRING" id="590646.G3AZE0"/>
    <dbReference type="eggNOG" id="KOG1754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_uS8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="154" mass="17661" checksum="73A912B0E220248F" modified="2011-11-16" version="1">MNPYFVRTLMRTFDEENHVTNPIRMTRTSVLADALNAINNAEKTGKRQVLIRPSSKVIVKFLTVMQKHGYIGEFEYIDDHRSGKIVVQLNGRLNKCGVINPRFNVKIGDIERWTDNLLPARQFGYVILTTSAGIMDHEEARRKHVSGKILGFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZE2</accession>
    <name>G3AZE2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TTI1 N-terminal TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92421</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZE2"/>
    <dbReference type="STRING" id="590646.G3AZE2"/>
    <dbReference type="GeneID" id="18250196"/>
    <dbReference type="KEGG" id="cten:18250196"/>
    <dbReference type="eggNOG" id="KOG4524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005544_0_0_1"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="1">
        <location>
            <begin position="30"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1158" mass="131140" checksum="5CA583897B781989" modified="2011-11-16" version="1">MASNHQSRSGVPSLPPLQPDTTRLLSSSLFHEVKSICVALSAMSLAPAASFDPQSHKLLSTLSQLQETLYHHKHVHTRGGNAYTLAPNFADYVFFPLSNLLKQSVLSDQIITNILHIISFLIDNCWVPNGQFSDTLADQLFPVTCYLIKGSGGNIEVMLQPKSSEFRMACTAATTALVRGVDRDYFAGNDMKRLSLLGDTSSVLLALLKSFSNPRSLEESETVKQLLEAMTRLFVHRIGTEKLTHIFPGVVSTLIAFVADSATLHWSTITEVVDLLRKLVVRVFDDKTLGVEPQTRDLTPDSLNHEWENGKENEIDRVHYTANVSVDSGNEHTSQSWLKATSKKLKLSLNTLFKSVLFQAHRGKVGQKQQLGDSIVFFVRDIYTHCFWSLFDELFALNIDVLCLVSYSRCYPDIGPLDQESQTQVLTEIIAYIEYAILHKASDLPGKLLTLKLEDLIDNKMVGVMKSTSEDRILQFFVSLRFHFLLLKKLDPPQVQQLIQRQIVKLKGSLVDVSVFTGAQMSRGDKKDFFKSYTGDTEPFENDNKLDNVQLPPYVNANNLKPLDNRRSPVSKKEVVSDLLHLSQMWTLSGPQEMSSLCYFEDNFSSQVETALSDFLSFLNGISTDRLLTLETLISGDTSHMDRGISLWLANQLVQNMKSEKFDIDEFLVLGDTEKQDEPADETEEMAYLIVNQSQELIEDLAPFLEDLTIVSTSKEEMLQNKMNEKSYAVALDSLGVLSSYLPKDEFKEHFLIEYLFPLFEALTFNSNTVIQSHAKNTVSLIAKNYYGDSLTELVLDNSEYLVDAVSLKLTSPGALTPALPGILLIILKVSGLKLLLTNQLSDILSQIFILIDSYHGYAILVEGFFIVFGELVAQIKQQYIPDRYLRKLDYHHSLYKPWGMTSIEEARALVDESRKVLDPFEGYDREKEYFHRSQDAPFSQLQEQDKEVDENPPEKEEIWTSMVPKNIYFIVQRVFIYGLRLLSHPSDVLKIQLLKILIDIYPILSTNYSLTLPLAADHWSDILALFPHQGQYSEEAAIKGLEFLTLMLETDRLQKDTFFSERFLDSCRMLLQRFSPSRHTSEVVKIDRFKRSTNVRLLKALCGYLVTGLNNYERSVPIGMAIQIMRIAMAIGTDGVSLGPQARNIAWVIRNQDVHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZN4</accession>
    <name>G3AZN4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112501</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZN4"/>
    <dbReference type="STRING" id="590646.G3AZN4"/>
    <dbReference type="MEROPS" id="T01.A13"/>
    <dbReference type="eggNOG" id="KOG0185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072435_0_1_1"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="270" mass="30527" checksum="2E2B50BB4B28A212" modified="2011-11-16" version="1">MNHDPYQWGRPSDQTYGQYNHAIANAKNAPAEHDSFPKMNTQNPIITSTSVLGIKYKDGIVMAADNLGSYGSLLRFNNIERLIKVGKETVVGVSGDISDFQQLQRILDELETEQEVYDNFGDNNLRAPHVHEFLSRVLYNRRSKMNPLWNSVIVAGFNDDRSPFLKYIDMLGVTYGASTLATGFGSYLAVPLLRKVIPEDKDYVNVSEEEAKKVIMDSMRVLFYRDARSAETFTLVTLNSEGVKYDKQVQVSNQSWEFAKDITGYGSKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZP4</accession>
    <name>G3AZP4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase HPA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112509</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZP4"/>
    <dbReference type="STRING" id="590646.G3AZP4"/>
    <dbReference type="GeneID" id="18246551"/>
    <dbReference type="KEGG" id="cten:18246551"/>
    <dbReference type="eggNOG" id="KOG3216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_32_1_1"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="152" mass="17234" checksum="98F2A5465525B3DE" modified="2011-11-16" version="1">MISIRPIAPKDKHEWWKLWCDPDESYLQTTGSLASVSPSTTETTFSRFLDPRVPLYAAVAQDSNGNLIGFATYLTHLGTKLTQENMYLGDLYVSPSNRQKGAGRKLLEFVFSEADRLNCPGCFWTTDKDNQTAQRLYNKVGVQADFVLYRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZU2</accession>
    <name>G3AZU2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_102777</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684926.1">
        <property type="nucleotide sequence ID" value="XM_006684863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZU2"/>
    <dbReference type="GeneID" id="18245582"/>
    <dbReference type="KEGG" id="cten:18245582"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_0_0_1"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31613" checksum="60A51DD9B80FFF62" modified="2011-11-16" version="1">MIEQLISITSHGPASPLRGSISGIMGSTSLACWIVLLMPQLIEQWRLKSADGIAIGFITIWFLGDVFNLVGALWAHLLPQVMFLAVWFCFADFLMIFSYLYYQHLNKVKKQNPQEHRPLIEHRRTSSTLTDIALEPSYHGIFTKFGLPILFVVGCGLMGFLVSDNGTDDTTPIDDTGDSISLGPQIVGYLSAVLYLGARIPQIVQNHRRKSVHGLSLLFFLFSTLGNLTYAGQILCYRSDSNYVLLNLSWLLGSLGTIFEDSIIFLQFYIYKDSISDDEFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZU4</accession>
    <name>G3AZU4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112980</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685158.1">
        <property type="nucleotide sequence ID" value="XM_006685095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZU4"/>
    <dbReference type="STRING" id="590646.G3AZU4"/>
    <dbReference type="GeneID" id="18246766"/>
    <dbReference type="KEGG" id="cten:18246766"/>
    <dbReference type="eggNOG" id="ENOG502S59H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133944_0_0_1"/>
    <dbReference type="OrthoDB" id="5416589at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020241">
        <property type="entry name" value="RNase_P/MRP_Pop7_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="153" mass="17290" checksum="488BE13FB99D24E7" modified="2011-11-16" version="1">MAGSDKIKRINGKHIKHRANIHISSVVERETTFLVKSSTPFVSALKRIHKMLDKFNKTITTNTRKYQGGDYKNVKFITVKGMGKTIETTLGIANKLQNEANYRVDVLTGSVEVLDEFAPPDSSDGPPKGAIQETVFQKRMVSYVELHVWLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0F9</accession>
    <name>G3B0F9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_113113</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685080.1">
        <property type="nucleotide sequence ID" value="XM_006685017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0F9"/>
    <dbReference type="STRING" id="590646.G3B0F9"/>
    <dbReference type="GeneID" id="18246828"/>
    <dbReference type="KEGG" id="cten:18246828"/>
    <dbReference type="eggNOG" id="ENOG502S2DH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_3_1_1"/>
    <dbReference type="OrthoDB" id="5069333at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="580" mass="66812" checksum="D450C39B209B9406" modified="2011-11-16" version="1">MSEPKRSRSGCSTCKTRHLKCDESKPVCLNCTHKNLRCRYGLKLQFKEDLESKNKAFGRQGVWSKRKNHDRTSSTVVPKDHNFHRFVAVRSQEKLMLLNYTYDDFESPPPQPLQLSMAPSSVPHALIRGFDDHGLITSNSDLVYTLVFYIESVSPMLNPVNMGNLKFHHGASSFLGGDNTKMVVHEGLDVGSLLQYSQKYPHVLSLMLGLSSIYLSKSAFVDKTQSHYWRMQGIRLRNLGLQHMAKSFQGESAEIRVDLWVSFLIITLYYLADECNDNWSNQLRSCQQLLRQSEVRAVTDPVERKLFTYTVEFFSYQESMGRTACHKSNVFNEEWTKHLGQAEGEVVLIPWMGCDKRLIRIVSDITDLSISALPQQTFREKRAAIMDELENIKMKHFNPDNFLYMIDNSLLDQSPASCDDNYGCLFYYYDQISDEAANMEEFCFLLTCEIKRLCGLLYATSCLYYQSPSQPSIVSLVTKIFNYTKFIIISNNFFWSSLTWPLYMISTQLDFADPMSEVQKLDILNMFDMIDQKGLGNVGKAKSAVETLWKKRSLYDRAKGKEKKTYWEFVVDPVCNISLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0L3</accession>
    <name>G3B0L3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Yip1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_119825</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0L3"/>
    <dbReference type="STRING" id="590646.G3B0L3"/>
    <dbReference type="GeneID" id="18248729"/>
    <dbReference type="KEGG" id="cten:18248729"/>
    <dbReference type="eggNOG" id="KOG3114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082766_0_0_1"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="293" mass="33395" checksum="C7EDDD502551CC6E" modified="2011-11-16" version="1">MSNGYTNLSGTDPNTSWDDQDLIETDDPITLPTQGQGGAPPAERVIQPQIPIDSTKSHMFQINFYRRYFDLNTEDFLVKIKQALNPINKSSSPVQNESEDEVTELYGFFWITGTLIFLMFVSSTGSNMLSHFLHSSKEKVKYEYDFDLLTLSIFLFYGYNLLVPFALYAVTSWFLHFPVRLSLTKLISIYGYTNILWVPITVVNLLIVLLVSNEKHHTILNILEWIIVLLSGCVTGLSNLSKISPVLERNTLQLYDNDLEKSRRLHIVLIGLLAFSHLLFTVVLEISFFGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0W6</accession>
    <name>G3B0W6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_134127</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685631.1">
        <property type="nucleotide sequence ID" value="XM_006685568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0W6"/>
    <dbReference type="STRING" id="590646.G3B0W6"/>
    <dbReference type="GeneID" id="18249770"/>
    <dbReference type="KEGG" id="cten:18249770"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_3_2_1"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="399" mass="44918" checksum="338E7D5C05626E50" modified="2011-11-16" version="1">MSENKRFLISGAGLVGLLIAQAFKARNIDFVIFDRDIDVHYRENAGWAITLHWALENFKSLLPPDLVEQIYAAQVLPGFHEKDTGKFIYINAASGDPVVSIPPSKRLRVRREQIRRMLLSGIDVQWNCKLDNIDTTNSQVTVTCSDGTVFTGDVLIGCDGANSMTRRIICPENGQLYQLPVRFCGSRVKMTKAETDQIAADFDPLLFQGTVPENNTFFWFSMLATPEYTQEEDVYYAQVNLSWNVPDYDEPFVTNVDKTEAMKVHSQGLNPKLKWLVDRAVEDPDTILEINLCDWPVVEWPHQTQVLLAGDAAHAMTMFRGEAGNHGITDAFELMKHIDEYLAGRKTWEVAAKDFCSGIKARAAPAVLLSRQACLDAHNFSKIRPDTDSPLLSMRKNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0Z1</accession>
    <name>G3B0Z1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113601</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0Z1"/>
    <dbReference type="STRING" id="590646.G3B0Z1"/>
    <dbReference type="GeneID" id="18247040"/>
    <dbReference type="KEGG" id="cten:18247040"/>
    <dbReference type="eggNOG" id="KOG1467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_3_1_1"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="534" mass="59937" checksum="27D87CA589921C8B" modified="2011-11-16" version="1">MSDKVNTAATEATKAPKESKAGESKSQEPTEGGALSNKELKELKKREKAAKRAAQKEAQGISPEQQQKLAEQKKEKNQERQMATNTNLRKKLDSSLIKDDNKKKIPAMFSHLETREQRNASSPSISHIVHPAILSLSLKISSYKIVGSIPRLTSMLEVFKTIIKDYKTPSNTSLQRHLTGHLSHQIEYLKSARPLSVSMGNAIRWLKQEISHIPLDLKELEAKTLLCEKIDDFIKEKIELSDRVIIENASKHITNGSTILTFGHSQVLEQLFKYCVTEQNKMFNLVIVDSRPLFEGKKLLRNLVDTHYMPGSEEVGSETTSEVSSISSRGPKPKPITQDFIKVHYVLINSLSSTILEDVDCVFLGAHAMLSNGRLYSRVGTGLIAMMCHNRNIPVLTCCESVKFSDKVQLDSVTNNELADSEDLLQNLNGKEAPKKKAVALEQFMKQFEHNEPQAPVKPTQKGKSQPKKITVGEEERDSKHESPLKDWKNIPNLNILNIMYDLTPPEYIKKVITELGALPPSSVPVILREYRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B117</accession>
    <name>G3B117_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-dehydropantolactone reductase</fullName>
            <ecNumber evidence="6">1.1.1.358</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-dehydropantolactone reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ketopantoyl-lactone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_130029</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16719"/>
            <dbReference type="ChEBI" id="CHEBI:18395"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.358"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>isatin + NADPH + H(+) = 3-hydroxyindolin-2-one + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27539"/>
            <dbReference type="ChEBI" id="CHEBI:28536"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.358" evidence="6"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685664.1">
        <property type="nucleotide sequence ID" value="XM_006685601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B117"/>
    <dbReference type="STRING" id="590646.G3B117"/>
    <dbReference type="GeneID" id="18249417"/>
    <dbReference type="KEGG" id="cten:18249417"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047011">
        <property type="term" value="F:2-dehydropantolactone reductase (A-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="12">
        <location>
            <begin position="38"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="11">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="323" mass="36348" checksum="2B64883BD65DA97F" modified="2011-11-16" version="1">MTTVQTYTQTAPVFKTVNTSVANKKVKFNDGNQFPIVGLGTWKAKDEDVYYSVKNALDSGYRHIDTAAAYGNEEQIGKAIKDSGIPRKELYITTKLWSNRHHDPVGAIKESLDKLQLDYVDLYLLHWPVFLNPQGTPARVPLLPNGQRDIVLDWSFVKTYSLMHDVHDLGLAKSIGVSNFSVKNMKILLAAPETKITPVVNQVELHPHLPQFALGELCAQHGIKLQAYSPLGSNGSPVLKDETLLTIAEKYGVSPATVVFSWMCRRDVIYLPKSLNKHRLASNLKSVDLSDEDVDAINRIHKTFSKRYNDQDWSPMKPFEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1I1</accession>
    <name>G3B1I1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="19">CFEM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_113721</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1I1"/>
    <dbReference type="STRING" id="590646.G3B1I1"/>
    <dbReference type="GeneID" id="18247099"/>
    <dbReference type="KEGG" id="cten:18247099"/>
    <dbReference type="eggNOG" id="ENOG502SFDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442735" evidence="17">
        <location>
            <begin position="17"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV65197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="222" mass="22687" checksum="06AE07D0261858C5" modified="2011-11-16" version="1">MQFGLLILYLSSVITASNWDTYPQVPKTASINGFADPIYSELPSCAKDCVKVSVGNTPCPYWDTGCLCVMPQWSGLVGQCIAADCEGEDVVSATSLAYSLCSSVGANLWLMPSSITAALTAAAGVYNEAVPSPTETAFNSLLGSLGISVEVQSSSSITSEAEAEAEATGNNTSSDSDSSSGSSSASSSGTSSSSSSRDGAMEIKVTGSLFMIILGSLFAILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1L6</accession>
    <name>G3B1L6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxisomal biogenesis factor 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113245</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1L6"/>
    <dbReference type="STRING" id="590646.G3B1L6"/>
    <dbReference type="GeneID" id="18246863"/>
    <dbReference type="KEGG" id="cten:18246863"/>
    <dbReference type="eggNOG" id="KOG4186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049216_0_1_1"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="230" mass="26359" checksum="4003D781E45421D0" modified="2011-11-16" version="1">MVADALIYHPTYAKLLRFLDTTPKREKSFRLVAYLSRFLSYYLYRTGYSKQVVDTFKTLKAQVTFLRKGMRFLKPLHHFEAASKAFDNKLMDPVLQQTTVIRNLGYAGYLTIDGFIFVKMLGLVDSKRWSKASTWASRFWLLGLVAGVINSLRSYQINTIKLKASDSDEKIDVKDVKSKLFKAKRKLIWDLLDTFIALNSLDYLHFTEGDVGLAGTITSVMGLRDLWAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2A4</accession>
    <name>G3B2A4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_103191</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2A4"/>
    <dbReference type="STRING" id="590646.G3B2A4"/>
    <dbReference type="GeneID" id="18245608"/>
    <dbReference type="KEGG" id="cten:18245608"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_5_0_1"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="433"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="713" mass="80745" checksum="AB06D65FE256A1F7" modified="2011-11-16" version="1">MSSPRSTNTLGVSLLNVYKSNRSLFLNASYIILITTAFSGATGTSQSSDKKPKDVESSTELPKKRKKLSKESTKRIFDAAIPHYTNAAVGFLISHIILLVIRAFLTIKVASLDGKLVGALVSKKLKKFGQLLAFWMFLGIPASIVNAMLNWTKSNLRKNLRINMTNSIVEDYLPDNLDANYYSLIQLNDSKIKDPDQRTSTDINRLASALSSLPGQLLKPTLDLLLCAKELSKSGVGSGEGTLALGLIAHFSTIILRFFSPPFAKLASERANLEGQLRSAHSKVVTNSEEIAFLRGHNRELDYLDYCYYQLERFLKMEQWKKAIHEIAQTFIVKYFWGAAGLVLCSAPVFINKYLGKEPDLSASGDFITNRRLLMSASDSLDRLIYARRYILQVVGHASRVSEFQDALHQIKQDKIAERKNEKSDNVRYGDEITFENVRLVTPADVTLIEKLDFSIKHGQHLLIAGPNGSGKSSLFRMLGGLWPCKEGQITIPETENMFYLPQRAYLCRGNLREQVIYPHTFEQYKKNKHGKTDKELYEIFKMLKLDDLLVGDRPWDEVRNWGEELSVGAQQRLAMARLFYHQPKFAVLDECTSAVSPTMEQFMYQHAQEMGISLLSVAHRPALWHFHNYLLKFDGKGGYFFGELDAEKRLKIEEERLKLEKSLRDVSTLRDRLQELKRVSNAQHIKYENSHKNLAQLGRDAAAQAEASVSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2G7</accession>
    <name>G3B2G7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_113462</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2G7"/>
    <dbReference type="STRING" id="590646.G3B2G7"/>
    <dbReference type="GeneID" id="18246969"/>
    <dbReference type="KEGG" id="cten:18246969"/>
    <dbReference type="eggNOG" id="ENOG502S7SV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149455_0_0_1"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV64671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="145" mass="16079" checksum="041B33C2C8880D8B" modified="2011-11-16" version="1">MSKQIYTVDFQQLGLPPLEAQVLGQYQSLASQLETLNLEIRKLTDAADTYKSSAEPSEPPSVTAEQLLDNLRHLEKKLGLVYTFFQGAVYQLFLQNEVEENDEEDQPHHHEDEQSLHDDGDDGDDGDDKDDDGGDGSDADASPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2H6</accession>
    <name>G3B2H6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113470</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with KAR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2H6"/>
    <dbReference type="STRING" id="590646.G3B2H6"/>
    <dbReference type="eggNOG" id="KOG2160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034955_0_0_1"/>
    <dbReference type="OrthoDB" id="448649at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031884">
        <property type="entry name" value="Sil1_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16782">
        <property type="entry name" value="SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442490" description="Nucleotide exchange factor SIL1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="389" mass="43616" checksum="862307937A9036F1" modified="2011-11-16" version="1">MRLSTLTLVILASKFLAAEPLPVNFQTSELICSPTDPTNCYPKLFVPTHQWQPIQPGQDIPGGLHVRLNIDTLQKEAKLLDSSDEATNDLVIVAESQDPSPAPARKPHKLDMTNINSFDSALDEVQSAANGAGSDSLDQALDVLIDLSHDIEFGTKLASDGSAFSNLNAIAAKSSPPVQEKVYRIIGSSLRNNPEAIATFVDKDTKELIGSWIKQLDTSDNLVKKRVLGIFHQLVTNARFKYQYFNGDFDLLSKFIDIYPKLNKSTKTRLLNILEDLKLVDEPSSESDDSRVSNYIQAKFLKSDFKTEDQFKLYYQTLVEIHQADKSLQGSKAFVTWLDEESGKRQQGLKERDGLYSNADKQFDKDMLETRHTVFGNPNAMRKHFDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2J2</accession>
    <name>G3B2J2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_113478</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2J2"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044091_0_0_1"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48770" checksum="F34AF89FBEDA9B87" modified="2011-11-16" version="1">MSPPSSIALGCSVAVVSSALQSLGITLQRRSHLLPIHLGDESTDNPQTHHQYSKLQRNTWLFGFFLFIVSNVLGSLIQITTLPLIILSPLQSIGLIFNSLLSCLLLPGETFTWKLGVGTLIISTGAFIIAYHGNAIPPPPDSDIDVDKRFKIIIHKLIDPRFMAWFISSFVLIGLLLLANSAITYKRNKFKNRIQQRSSRSTTKALEKLKFFKGVNYGLISGTLTAHTFLFAKSLIDVVVESIFAGPHDVGSITRSITPYFLLIVMLTIVGCQLTAFNLGLAQISSSILYPLCFLVYNLMNLINDLTFNHLLANQRLTIGQLFWVLLGLCAVLFGVVLISWDSAVGSNVQRLAYDNEEEYILHSKFPYTDNLNEMSKMVDSSSTYEMETGYLSIDSTHLNPHGPYPLSTRRSAVSTRNKKRVLSYEQQQLLQQFETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2N8</accession>
    <name>G3B2N8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ThrRS/AlaRS common domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_97577</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685914.1">
        <property type="nucleotide sequence ID" value="XM_006685851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2N8"/>
    <dbReference type="STRING" id="590646.G3B2N8"/>
    <dbReference type="GeneID" id="18250697"/>
    <dbReference type="KEGG" id="cten:18250697"/>
    <dbReference type="eggNOG" id="KOG2105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_7_1_1"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Threonyl/alanyl tRNA synthetase SAD" evidence="6">
        <location>
            <begin position="220"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="448" mass="49551" checksum="181A5A08576B91EA" modified="2011-11-16" version="1">MATKTGSTIVGALACQKESFLKTLATTVCSCEPHKGHITPKDKQNKNKKKKDSDASNGTEVKYAIELADTVIFPEGGGQPCDQGFIKSETDEVFVSEAIREGLTALHLSNKPLVPGTKVNVSMDWARRFDHMQQHTGQHLVSAIFDQYDLETLSWGMGDVTCYVELPKKVDEELVNEVNQKVNQAILDAIPITVEVPDGHGHELDLSHLPDDYDISKGLVRIVSIGNLDRNPCCGTHLKNTSQIQAVSILNQVNVRGGNSRVHFVCGSRVYKFAQKNYDILKNVSGGLLSCQPDEVYEKTKLLNDNYREANSTKNNLLKELMGLEAKRMFESFKNGSTLEWAYRKDTDAESLNLLQKELLTLVNNNKDSGIDLDKTHTAVMFTGLVNEPGTIKIMGPESTELSGEIKKILSTIKGGGKGSSFQGKISKYEKGEIDSLVNYLNNFRLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2R9</accession>
    <name>G3B2R9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1770-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_103249</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685551.1">
        <property type="nucleotide sequence ID" value="XM_006685488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2R9"/>
    <dbReference type="STRING" id="590646.G3B2R9"/>
    <dbReference type="GeneID" id="18245612"/>
    <dbReference type="KEGG" id="cten:18245612"/>
    <dbReference type="eggNOG" id="ENOG502SE22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156033_0_0_1"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15192" checksum="4E71D00324AE9A13" modified="2011-11-16" version="1">MSTITNLPLPDLRFENTFMKSLRTYAAESAKTPPQAVPELALRTESEIDLLNEQLDLDEQSQIDQPLPPITPAIVAYAIIKDQILMPLLQGILYSGLILVSKPYLRLVVLQGQKFGSYLATILGVHQFTRPRPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2X2</accession>
    <name>G3B2X2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_134096</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2X2"/>
    <dbReference type="HOGENOM" id="CLU_088624_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="274" mass="32535" checksum="9770FB7CC11A86B0" modified="2011-11-16" version="1">MTTRNFQWFKKSLNHLKHTYIYYDLKTTDEIQRKPGLYSQIFCIPNKYLAATFLSLDIPGEEIVVKVFDPGYYFISNWSYKYQYDDVRYNIQQYFENDIEHYQKVNDFNQSHRCKIDTLSSFNAGFCSFWKDQSKPKDSNNYIASGLTIFMPKLTKKPKTQEDYLKGLKGLITMENAGLAEFAVNYENMFMDRGKFIFSNYSSPTEESDDTPEVESFQSQRIKEFSEVWHNKDPEYSYIIAKESVNRFEEETQREITLDNDVQNPNSMRNKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B326</accession>
    <name>G3B326_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_93575</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B326"/>
    <dbReference type="HOGENOM" id="CLU_1272118_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="217" mass="25233" checksum="EAF10FF10D85B25A" modified="2011-11-16" version="1">MNTFNKTLGRAVGPKFCINHQVYPFTNKYVMKFNRKVHQRVYKRVLGAFRSSDQCEMSTQFKEFEFGILKGTYSIPFSFGCNSPTIYSVDFCQSYELEMVLVTPKRTFTERREVLIHKQVPFQIVSIRETVNDQVFNLTTPKSFYKNKTNMVKFEGSGNFYMCITIAQYTKVTVKEGDSFTVTTRQRVYHGNKQEVKIPGKALRQLSTGYSTCEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B327</accession>
    <name>G3B327_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_134643</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B327"/>
    <dbReference type="GeneID" id="18249807"/>
    <dbReference type="KEGG" id="cten:18249807"/>
    <dbReference type="HOGENOM" id="CLU_789879_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="351" mass="39604" checksum="5F792A48F4DE84E1" modified="2011-11-16" version="1">MNNSAPQIEEDQANYSLSLLNLALSQWDALVKRFVGNIMNELKGNPNDQSFQGNIRSLSDGSPIWHPATELQWESGFPTFGDLLQANGESIREKLAQVTGHNTTSAQDSFLEYLDLLNFNRLEGIPLKQIYARLTNSVKAQNASLVLPYTDDGKPATFTEEITSLESLRHPTLCSIYRQYGFTGAATSVSIIQALKPIFFEHHRDAQSFSRIFARMGNDMINMINTTSDLGTVIREEMTGMEERMRSEMTGMEERMRSEMTGMEERMRSEMTGMEERMRTEATAREERMRTEVNGLRTVVREELPALLAHQFTVLFQPFLQQLSTRALQGIENPQTAHPNANTGDYAADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B335</accession>
    <name>G3B335_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_130409</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B335"/>
    <dbReference type="STRING" id="590646.G3B335"/>
    <dbReference type="eggNOG" id="ENOG502QQB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010316_1_0_1"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="2">
        <location>
            <begin position="368"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="1">
        <location>
            <begin position="539"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="1">
        <location>
            <begin position="658"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="85467" checksum="48336F359C9D221E" modified="2011-11-16" version="1">MLNPVYDTDQELANLMAKLQHSTTLKKGGGKRNVYKVGGLDVCSWRGLFTVGNKIVVRGYDKFFNVGEVPQTKPQTLAADTTGPYELTVKENGCIVFIGGLEDGTIVVCSKHSTGARDDLTRNHAVEGESQLKHSLEAIGKSVEELAKMLYKHNITLVGELCDDSFEEHIMKYSGNDAGIYLHGINHNTIDFKTYPMDAVREFALIWGFKCVESFQKTSYTDLTSFLDKCQETGTWHNREIEGFVVRCKISEGGDFFFKYKFEQPYLLYRNFREVTKSYLNGKPYNELLKRYGKEKYILSKYISFITEYFDKNPDKRDLYLQNYGIIEVRNLFLQSLGLNEISGMNLLAINEELSRTMEFSQVINKYVLIPIATVGCGKTTVAAALVDLFGWGHIQNDNIANKSKNSLVKQCLRSLFTEEVVVCDRNNHQKRERKQLFEQFYQFKVDELPANTSLVFVALNFIPRNTNMKELHKITLDRITQRGDRHQSIKSSTDPKLAEKVLGGFISRFQPIAPNYEPDSEFDMIIDLDFKDSPADSVKKVISSLTSEFPLLIPSPTSDEAIDSAVAKALTYEPTFTKTFGSSATSKSKKKVDFFGIKVDHPTIVSVLNQHCGQHPVWTHLRHSNRVQPEFHVTLSHMSASQAHQVQWDAIVLCPQLICLQVRVSDFADAHGNKTHVPITNSILHVTVGTSSPEVKPYQSNVVLDQVATTFSNLSLNDAGPSEPVQSVTVADGTTVEIISLPVPRPTLWSQSLFAHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3A8</accession>
    <name>G3B3A8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantolactone reductase</fullName>
            <ecNumber evidence="4">1.1.1.358</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-dehydropantolactone reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ketopantoyl-lactone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114149</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16719"/>
            <dbReference type="ChEBI" id="CHEBI:18395"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.358"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>isatin + NADPH + H(+) = 3-hydroxyindolin-2-one + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27539"/>
            <dbReference type="ChEBI" id="CHEBI:28536"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.1.1.358" evidence="4"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686686.1">
        <property type="nucleotide sequence ID" value="XM_006686623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3A8"/>
    <dbReference type="GeneID" id="18247289"/>
    <dbReference type="KEGG" id="cten:18247289"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047011">
        <property type="term" value="F:2-dehydropantolactone reductase (A-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00051098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="280" mass="31250" checksum="24DF34CD36BCFB32" modified="2011-11-16" version="1">MVPLRTLQNGSSIPTIALGCYNLPAATTGELVFQACHAGYRHFDTAVLYHNESEVGQGISRWLAEGNHRKDIFYTSKLWNSQCGYKQATAAIDDCLAKVATLEYIDLLLIHSPLCGPTKRLETWKAMEDAVIAGKVKSIGVSNYGIGHLEQLVNWNQLRIYPQVNQIEISPWLMRTEIADWCQAHDIVVEAYAPLTHGYKLTSPPQEVKSVMDKYGVGAAQVLIRWSLQKGHLPLPKTGRIERLAGNLDVFGFELTAAEMKQLDHPEAYEPTDWECTDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4G2</accession>
    <name>G3B4G2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_121528</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4G2"/>
    <dbReference type="GeneID" id="18248854"/>
    <dbReference type="KEGG" id="cten:18248854"/>
    <dbReference type="eggNOG" id="KOG2137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_851403_0_0_1"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="327" mass="38149" checksum="8216ADBB391DC519" modified="2011-11-16" version="1" fragment="single">MFKSVFKSGIRATYDVSSNASFVNEPWHIYTAKHNTTGKLASVFIFDKAKFESVIHQLCSRISNTKNPKVIINECYELIKYEVGQMAKLKHPQILTIYEVLEETKSKFLFVTESVTDNLMTVDFEKLDELSIQKGLLEVCKGIQFLHNYCSIVHMNLQPSSVFINQQGDWKLTGFRFLQNLNEISPQERESFFLMNNTSSVPFMNLNMNFVAPELVIDRQSKLDFGNDIWSLGCLIYYIYNKGEYLLNCFDQNSISDFKGEFRKFETKFYNHRVSDLKYVLKDIPDQLYGTFPSILARYPSDRINIDQFIDSDYFNGSLIKVMWFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4K6</accession>
    <name>G3B4K6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114004</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="2"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4K6"/>
    <dbReference type="STRING" id="590646.G3B4K6"/>
    <dbReference type="GeneID" id="18247211"/>
    <dbReference type="KEGG" id="cten:18247211"/>
    <dbReference type="eggNOG" id="KOG3082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_0_1_1"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="6">
        <location>
            <begin position="213"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="336" mass="37139" checksum="3393EEE8DD4F3FD3" modified="2011-11-16" version="1">MVIKPLQIAFFGSDRFSVAALDHVLRLKAHTPLIESVHVITRSIKPKGRKLVTYEDLPVGLFAASNGVSVLRADSPSEINRLLDQFRFNLAVAVSYGQLIPSHFISAMQFGGLNVHPSLLPKYSGSSPIHYALINDDKFTGVSVQTLHPTKFDRGDILLQSQPVEIQDTDNYTSLESKLGDIGGEALTQVLNQGLYRETKPLVPQTKYSTAFKINTSMAQVKWDQTSRQIRRLGDALGPLHTYVRCNPSKKLNSKSPVYKRVILEDLKEIDNGVYAELGVFSLDRATNTITAGTGDGALSIGSLTFECCKAEDANSFYKRFPKRTNKADFQFTVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Q5</accession>
    <name>G3B4Q5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosome biogenesis protein ALB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_105659</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Q5"/>
    <dbReference type="STRING" id="590646.G3B4Q5"/>
    <dbReference type="GeneID" id="18245830"/>
    <dbReference type="KEGG" id="cten:18245830"/>
    <dbReference type="eggNOG" id="ENOG502S14D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103824_0_0_1"/>
    <dbReference type="OrthoDB" id="4086742at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="160" mass="17887" checksum="CDDDA73844E4E858" modified="2011-11-16" version="1">MPSRNSINKPKDKMLRNSHASSIGKKRASRTRESTRSATSRYNEDALPRPSDSRSIAVYTGNVSNPTHLTTNTLSNKKAKKLARNQKYVEKRLQKDLDDQMQTDEPKPINSLIKLKTKVKGENSTEKIRKALWGVVNGNDLSMFKVSPQANGTTVGVQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Q7</accession>
    <name>G3B4Q7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketopantoate reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_134426</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Q7"/>
    <dbReference type="GeneID" id="18249792"/>
    <dbReference type="KEGG" id="cten:18249792"/>
    <dbReference type="eggNOG" id="ENOG502RPVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472506_0_0_1"/>
    <dbReference type="OrthoDB" id="4017860at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="65909" checksum="21AA592379E3A65A" modified="2011-11-16" version="1">MVNALIFGNSSSIIYLSYMLSSSGWYITVCNFNNSKNLHSNWSIQLGKTKVSFQVHKQVRNIEEVHGKFDLIVFTEAFFGIFSTKISKFRGFLNDKTKVIVDCNECPWFFEKVNDVLDTVVLAMYSDIDCRRLSSKSNMFILVGDKSDLTLYLGVLTGRNKKPNVELILENAETDEALSHFVASCKARSVILVMIPFQSYHMLIQIIWKNLIRVICFHTLSIVFEEKDVLALSNSSFVVPLMKGTYQELLYLSDKLNLKLFPSINSPKAISSLQLLILMERDRYLKRKSELKLDYNDLDSNQLYYNFVNGFSLTIICTLNFLLNQAFELDVDAKYLESLNSFLIRLISIRTSQHSNFFYLRKRMLQFDPISGIPPKKNMMNFPPFNPLPIPSPPKQFFNSVVVMMVRPEVKADYPKDDASFVSVDSAIKDIVNEYAPDTFYDTQEASDISSPTSTIAQDKFSYPSGNLSLPKHPQNTGQQMASYQSHSRFYYTSAAANQYSPVLRKASSFHHLQPTITKNTSVQQLKETHSSIMEAVQFYDCIYDQNTRYGKYDTSTAFANSANNSRSSQSSSKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B522</accession>
    <name>G3B522_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114430</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B522"/>
    <dbReference type="STRING" id="590646.G3B522"/>
    <dbReference type="GeneID" id="18247424"/>
    <dbReference type="KEGG" id="cten:18247424"/>
    <dbReference type="eggNOG" id="KOG3331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_872105_0_0_1"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="297" mass="33859" checksum="79971DF5F2C11B65" modified="2011-11-16" version="1">MSQVFKRQLSASVKSCARNKPLKFSDLKSIQLREPITPTHRNFDVSPDHPLWAFFGNGSNSEHAYRTSDELDTTSRAWTMPELRRKSFDDLHKLWYIILKERNVIATERRLANAIDNVGTTALSDLDAKMGLSHKRIKQVLLERQTAYERAQTLTSDINEYLANFEQRYINAAEDEIASENDKLVRLQYAVFGIQPALEDYNLESDINQKFVEGISFIAKVKLGRHLAQNPNSSVQFPLNGVVEELPFLIRSVDQAVEEVSALRESGQSVLLDKIDVFPFVRNALGKVLEEFNQQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B577</accession>
    <name>G3B577_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114476</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687354.1">
        <property type="nucleotide sequence ID" value="XM_006687291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B577"/>
    <dbReference type="STRING" id="590646.G3B577"/>
    <dbReference type="GeneID" id="18247438"/>
    <dbReference type="KEGG" id="cten:18247438"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57401" checksum="CA15C640B03E988E" modified="2011-11-16" version="1">MSEEKLTNNTVEVHNSGTSSDKHQPEEESHYTGPLRWYDKKIVSFLPAYSESMVQIVMLAFTCFMLPGMYNALSGVGGAGISLSVSNNSSVSLYSTFCGYGFFAGWVCNIIGTKFSLMFGGVGYVIYSGSLLYYTKHSFTNADGVVEDYGGAAAFVVAAGAILGVCAGQLWAAQTSIIISYPAEHLKGKAIMTFWVIFNLGAVIGSAISLGNNMKNNSSVATDGTYAAFIALMCSGIIIAGCTLRPHQVWRGGVGSERVVQQQFPHWKVELINMAKMLYKEPKIYFLFPMFFASNWFYTYQFNDVNAARFTIRTRSLNSLLYWAAQMVGAAIFGNILDWKRFDRKTRVKIGWSIIMVLTFVIWGGGYDFQKKYTRESVAGMALIDFKKGSTYVGPMFLYIFYGMYDAMFQTFIYYTLGAMSNNPKKNAIYGAFFKSIQSAGAAIMWRLDYYEVPYMSMFASSWGLCAGALVLASPLIFFKISNHTEDAEDDLQGELLNRGLEISKSISQPEPKNPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B584</accession>
    <name>G3B584_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_114480</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B584"/>
    <dbReference type="STRING" id="590646.G3B584"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129458_2_2_1"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="118" mass="13674" checksum="0E932D33FC94BAC8" modified="2011-11-16" version="1">MSPAVGSNKRFQTIAINLINNIQSHRFSSLFLQPVSKREVPDYYEIIHEPKDLKSIMKAVKGKSDESYNSLQQLERDVMLMFANCIMFNHSDKDLVNLARTMRDDAVNTFKLFKEAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5B6</accession>
    <name>G3B5B6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_135013</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5B6"/>
    <dbReference type="HOGENOM" id="CLU_088624_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="283" mass="33275" checksum="D7CDED1F7D54F66C" modified="2011-11-16" version="1">MTTRNFQWFKKSLNHLKHTYIYYDLKTTDEIQRKPGLYSQIFCIPNKYLASTFLSLDIPGDEIVVKVFDPGYYFISNWSYKYQYDDVRYNIQQYFENDIEYYQKVNDFNQSHRCKIDTLSGFNAGFCSFWRDQSKPKDSNNYIASGLTIFMPKLTKKPKTQEDYLKGLKGLITMENAGLADFAVNYENMFMDKGKFIFSNYSSPSTRPSSAESDDSQELESLQTQKIIEFAGIWRKKDPEYSNIIAKESVNLFEEEIQREITESQQSRMVTIPIINREKSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5B7</accession>
    <name>G3B5B7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_93950</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5B7"/>
    <dbReference type="HOGENOM" id="CLU_088624_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="221" mass="26034" checksum="EE731A2A13F75206" modified="2011-11-16" version="1">MRKPFNLHGYYFVSNWSYKYQYDDVRYNIQQYFANDIKHYQKVNDFNQSHRCKIDTLSGFNAGFCSFWRDQSKPKDSNNYIASGLTIFMPKLTKKLKTQEDYLKSLKRLIAMENAGLADFAVNYENMFMDKGKFIFSNYSSPSTRPSSAESDDSQELESLQTQKIIEFAGIWREKDPEYSNIIAQESVNRFEEETQREITESQQSRMVTIPIINREKSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B659</accession>
    <name>G3B659_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTEDRAFT_123586</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B659"/>
    <dbReference type="GeneID" id="18248962"/>
    <dbReference type="KEGG" id="cten:18248962"/>
    <dbReference type="eggNOG" id="KOG1907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_1"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="21">
        <location>
            <begin position="43"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="20">
        <location>
            <begin position="209"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="473"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="22">
        <location>
            <begin position="690"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="19">
        <location>
            <begin position="868"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV63388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1346" mass="147345" checksum="BA01BC1915A4B77B" modified="2011-11-16" version="1">MSDKFLVIPGPRALSDFRVQNFVKEIESKLGKSSIIKSVSSSYTHYVSLKTSLTEPQSQLLQTLLKYDTEVDASVEFNAKLLELSVLRGDDSRETAAFKLDSNVYLIRVLPRSGTISPWSSKATDIAVTCGLVDQVERIEKGLSLLIEVESGFNFGDALDKGEILTSVFDRMTQTLFVNDHLPKYNDLFEHHSPKPLVHVDLLGGSENLAKANKELGLALDQGEIDYLINAFTNVIGRNPTDVELFMFAQVNSEHCRHKIFNADWTIDSVKKDLTLFKMIRNTHSKNPQYTVSAYSDNAAVFEGPEGYVYTPDFATKQWKSIKEKVHTLVKVETHNHPTAVSPFPGASTGSGGEIRDEAAVGRGSKSKAGLSGFSVSDLNIPSLPQPWERKVGKPNHIASPLDIMIEAPLGAAAFNNEFGRPAINGYFRTLTTEVNNSKGDNEIRGFHKPIMLAGGMGAIRPDLALKDTKITPGAKLIVLGGQSMLIGLGGGAASSISSGEGSADLDFASVQRGNPELQRRAQEVISACVSLGKEHTPIQSIHDVGAGGLSNALPELVHDNDLGARFELRSILCLEPGMSPMEIWCNESQERFVLGVAPENLDLFTKICERERCPFAVVGEATEEQRLVLTDSLLNTTPIDLEMSVLFGKPPKMSRVATTAELQLPEFSVSELDVSDSIQRVLQLPAVGSKNFLVTIGDRFITGLVDRDQMVGPWQVPVADVGVTNTSLGDEILITGEALAMGEKPTLALISAAASAKMCVAESLLNVFAADIPALDRVKLSANWMSAASHPGEGAKLYEAVQAIGMDLCPDLGISIPVGKDSMSMKMKWDDKEVTAPLALTVTAFAPVDNTSNTWTPLLEKKDDTVLVLVDLATKVQKALGGSALAQVYKQVGASAPTVHSNKEFKSFLESLVVLHKEFDVLAYHDRSEGGLLTTVAEMAFAGRCGVELDLKGENAFVELFNEELGAVFQIDNAKYDEFVQVFVTNGLPAEYISVIGKPTTEQTLKISFNGEQIYSNTRSALQKLWSNTSYHIQTLRDNPITSKQEFESISDDSNPGISYQLTYKVGDDLGIKSLSTERKPKVAILREQGVNSQQEMAWSFQQAGFDTYDVHMSDILSGRVSLKHFTGLAACGGFSYGDVLGAGAGWAKSILFNELARKEFKEFFERSDTFALGACNGCQFLSRIQELIPGTKNWPTFERNFSEQYEARFVMVEIVPEQTNSIFLSGMEKSKLPIAVAHGEGRANFTSDDEESGFLADKQSVIRYVDNYGNPASQYPYNPNGSPHGIAGISSQNGRVLALMPHPERVTRKESNSYYPKQDAVEWEGYGPWIRLFRNARKWVRDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6D7</accession>
    <name>G3B6D7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein GLC8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94195</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687235.1">
        <property type="nucleotide sequence ID" value="XM_006687172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6D7"/>
    <dbReference type="STRING" id="590646.G3B6D7"/>
    <dbReference type="GeneID" id="18250371"/>
    <dbReference type="KEGG" id="cten:18250371"/>
    <dbReference type="eggNOG" id="ENOG502S2VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070379_1_0_1"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22457" checksum="95F24C23D03A9100" modified="2011-11-16" version="1">MDEPRGILRNKAEVEPKHTSSDKLDRQEVIRNTRLNSNLAQNSNSKGDLIRNKIAVAKKQQSDQGKKTYPDHLKWDEVNLYQTEQEKAATMKIDEPKTPYERGFDPTGEYYQDDDEEEIPGFELGESAEHDTHKVQSLGGGEILQDQNAQQDEPEPEKPLTAKEKHQKFEEMRKQHYHLKGSVLGKKIEVSDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6I4</accession>
    <name>G3B6I4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_98573</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FYV7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6I4"/>
    <dbReference type="STRING" id="590646.G3B6I4"/>
    <dbReference type="GeneID" id="18250784"/>
    <dbReference type="KEGG" id="cten:18250784"/>
    <dbReference type="eggNOG" id="KOG4851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105541_0_0_1"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="157" mass="18817" checksum="BD7037A3F14EC436" modified="2011-11-16" version="1">MSGGRKFDSKKYKDLRDFKSKEIKRSLVHRARLRKNYFKLIEKEGGRPSTDPVDELKKEPTKGENTHRETKGPRHERNDVKKSNLTYYEKSQLIKQRKEEKRQAILQDVRERRDKIEKSNQQRDRMKEKLSQKTKHGQPLMGPRINNLLDKIKKDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6L5</accession>
    <name>G3B6L5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_123855</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687290.1">
        <property type="nucleotide sequence ID" value="XM_006687227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6L5"/>
    <dbReference type="STRING" id="590646.G3B6L5"/>
    <dbReference type="GeneID" id="18248985"/>
    <dbReference type="KEGG" id="cten:18248985"/>
    <dbReference type="eggNOG" id="KOG3867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="550" mass="62545" checksum="9408B51CA1BB528B" modified="2011-11-16" version="1">MTQSKKPNFIIIVADDLGFTDTSPFGGEIDTPNLKQLADNGLRFTDFHTASACSPTRSMLLSGTDNHIAGLGQMAEYTRIYPEKFEGKPGYEGYLNFRVAALSEILQDNGYYNFQSGKWHLGLTPEYWPSKRGFEKTFTLLPGAGNHYKYFPRDENGDYIKFLPPIFQKDDEHFDPEDLPEDYYSSDYFTDRFIEYLNNDDIRGDRPFFGFLTYTAPHWPFQAPPEVIQKYAGVYDDGPAELRIQRLKSAIKLGLVPEGVEAHQVETQRQKAWKDLSDEEKKIESQIMEVFAAMVDNLDSNVGRVIKELEAKDELENTFILFMSDNGAEGMLLEALPMSYQNFQATVSEYYNNSPDNIGGKDSFFHYSDQWAQAATAPSYMYKMWATEGGIRCPLIIHHPELIKKPAIKNGFTTVMDILPTVLEVAGIPHPGSQFRGREVVPVRGKSWLSYLKGNQDFVHSEDTVTGWELFAQQAIRKGAFKALYIPKPLGPDKWQLFNLRDDPGETKDLAEQNPDKLQELLEHWAEYVAETGLIEIGGDFKAHYKTLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6S6</accession>
    <name>G3B6S6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_130567</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6S6"/>
    <dbReference type="STRING" id="590646.G3B6S6"/>
    <dbReference type="GeneID" id="18249455"/>
    <dbReference type="KEGG" id="cten:18249455"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017361_3_1_1"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="118"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="389" mass="45088" checksum="ED79313A85B472E7" modified="2011-11-16" version="1">MWYLHDALVSYLCNHLSRTPKINHYKRSTPPISVPLNKLFSNTFPLSIHESIQDYKVKDDLFSFQHNLLSTLPFYPNPDKDGRSSEVIQVPIDENNNYINEYVIYPNHKTKKAYASANHLVMVHGYGSGLGLFLKNFGAVTMDNWVVHAIDLFGYGCSSRPPFTPTSFEQVEAWFHDSFATWMRRRQIPRQNALVMAHSMGAYLMASYGINVDPDFCRRLVMVSPGGIIDHKKPIVIPAYFERLWERNISPFSLVRKASFYGSKLVSGWSYRRFSELPDSERVSLHKYVYGIFQARGSGEYMLNYLLKPGANPRHPMVDRKIERCNCQFDWWYGQDDWMNVHGGEVCSERLRRSGKSSTVVEIADAGHHVYLDNATEFNRMLVEKMRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Y2</accession>
    <name>G3B6Y2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_130596</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686841.1">
        <property type="nucleotide sequence ID" value="XM_006686778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Y2"/>
    <dbReference type="STRING" id="590646.G3B6Y2"/>
    <dbReference type="GeneID" id="18249461"/>
    <dbReference type="KEGG" id="cten:18249461"/>
    <dbReference type="eggNOG" id="ENOG502QT5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022324_0_0_1"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="250"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="617" mass="68201" checksum="B18DFDD5821621E5" modified="2011-11-16" version="1">MSDPSSYPSSTSSSASDVGSRRQRIFGLARTARDVYIPRISDSVTQLATGVSTRAFANDKYDPDGNIRVPEDASITLYPTYTRQDPDGNYHVDVGGWLACPGAMTRKNRLILSLVKQIVRYDNSATSTAISNLESDGLQPDTLDDSDAETISSVDTTSSAYSNNDETLRTRLAAFIARFVANAKLTVTVGSRDELETSKLVSKDVFTDRNGCFSDCITVPYVPGLVQVVAGHQPAVFACEPVDIVSNDGVAIISDIDDTVKLTGVTGDKRTLLTSLLLQDVKSWTISPVVSWYNQLCESNKVTFHYVSNSPVQLLPTLLQYFTEVGLPSGSMHLKQYTGNLMASLMEPSSSRKRTVLTKLAEDFPRKRFVCVGDSGEYDFESYVDLASRYPGKLAAIYIRVVPNSMSFLKEDKIVDEVNRILTKPAHEIPRPINPRSVSTAQQKINPEDLEDLIDLSDTIPELPHKTKLPPTIPKKPSSLRGNLVRKPPPSSPESLVEMPPKLPTRPSTLGLAKAHTDTEVIGAPDLPPRRRPATTIAYETPTRDEILDNLHNIYYSHHFEDLQSIDGKGAEWIERAMTGAKMLENTGTKVRFFRDDEDDLYDTTCEVLKDIVRESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B708</accession>
    <name>G3B708_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vps52/Sac2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_130612</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B708"/>
    <dbReference type="STRING" id="590646.G3B708"/>
    <dbReference type="GeneID" id="18249462"/>
    <dbReference type="KEGG" id="cten:18249462"/>
    <dbReference type="eggNOG" id="KOG1961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010797_1_0_1"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="6">
        <location>
            <begin position="67"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="7">
        <location>
            <begin position="328"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="7">
        <location>
            <begin position="417"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="641" mass="73593" checksum="58F71C6591012D6C" modified="2011-11-16" version="1">MAFWDIVTRLSGELSTSTANVLRAEATNNNEQVLPSRINNLSDEELLFLTSKFEEFSMEFRTFKQKLVPIEFVLENFNTELSQLSSSLVSLHQQSNQLSHNLDSQKGTIEKLNPIIVDLIIPTDMVQSILSGNVDASWIENLRFINEKLMLIKQLEEEKLEERLITLYKDSEAFKQLKEGIDILVVKATERIRDYMIIQIKHLRSSTSESSQKIQQNLLSVKEAFAFLKFHQPKLADQLQLAYFYTMRWYYGSRFSKYLYALQKLNLRHVDSTMVLGADGATGTEDKLGYIGGGLKSWIYAGGSSANSQSSPTSFQHNKVTLLEYLGSVDKRLEIINTNLEDLHKSAMPAQIAETTPFGYWVEFVFNQWFTALLDNVVVEYLFVVEFFFQGEEKYHTVEFSNPVTGEPEKKDWSLLMFDNVYKVGREFLSWLITHMPSIFSAANRASTTLNSSRMTHTFQGSCDVYALLLMIRIIQTSSIQLHNQFHIPVLEDHINSLLLILWPQFTRVIDLNCDAMKKTIIRIGGNKGNLAPSSLTQQFGQMLSGLLKLSIIDVDGTRKIETLRGEPLYTSITRLRNDFENTLTKVSNQVKNPTDKEIFLYNNYFLIVNILKNENQDTSNDFINEQIDHFEKLCKAYENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B738</accession>
    <name>G3B738_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_134924</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686882.1">
        <property type="nucleotide sequence ID" value="XM_006686819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B738"/>
    <dbReference type="GeneID" id="18249823"/>
    <dbReference type="KEGG" id="cten:18249823"/>
    <dbReference type="eggNOG" id="ENOG502S51X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077704_1_0_1"/>
    <dbReference type="OrthoDB" id="4096107at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013268">
        <property type="entry name" value="UTP16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08297">
        <property type="entry name" value="U3_snoRNA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="227" mass="26249" checksum="0872A8EA0D09407F" modified="2011-11-16" version="1">MRYLSIKTLRDLSISMVATRNQSKQAKKIKFDDEDVSIDLPLGKTEDVEDPAMLSEEENSSEDDSDEGPEEESTNKAKEDLLAQEKARKKAEAEAKREERQRRRQQDLYNKQQQESKKTKQQKLPSIEILPDILPDEILEAINDENVELASETIQPRHKKIEDFDVELKKQLKLEKLKKLKALNKSSIKKGPVHVKVLSSLKGVPRAESKIINSREKWLKRKSLHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B755</accession>
    <name>G3B755_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_98285</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B755"/>
    <dbReference type="GeneID" id="18250755"/>
    <dbReference type="KEGG" id="cten:18250755"/>
    <dbReference type="eggNOG" id="ENOG502R1XI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334934_0_0_1"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="655"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="921" mass="105567" checksum="451D855B33A9DB2E" modified="2011-11-16" version="1">MSDSFANLYWSPDYVTGIDSLKKQTNVSLKQLHELRQLVFNFMNYYHANSQFLDKMVGDSSHSSFNPETIDMPPKPALSREWLKRRNVSQGNRQQEAMKTTDSSGPTSPSKIEKVTMDVLLSSYVKDISSEALTLQGLASVIDREVLEHINDFIKNHEPYIHTSIDHLDQVVNDYITTYADVEKVKADYNECKRAKEFADNDANSRQKSVEDSENTTADEIEENTSFASESSVTLNETNDSVKDEEGSEGQEFDFPLTIGPAKLRSQKELSSFLRDCMSRIEMTKRTFPLPGQKPEIFSGDELCKFLVYRRPFKLNTTRINLERFGQGLLDLKLIVGTGLVGSKRFKSEGMWFEWSELAEYVSKYEGSTVVSPPSSLSSAEKPKMRIIDEQTSKQVNEIASQTGKKFNDMFRSMKISILHTNYPERLEKLEEEYNEKYYELYELKYLIEYEVRDKTQYLEKFEKMKIGLIYQSLSKLSELIYNFSLKSTTRLRDFASNMLTNLNNPQNYENDYHKLLDTFSTGIYSPSILSPDNFKKNSYSTTQANNNFQNLKLQFNLYKDIPLQLQLFQTDKENELLSFASLPFFIYQLTRLIENKEQNLENLKDSWESVIDHRGYWHLQEEIIEAISEENFENITISDEDSVQQKMIEKIIALLNSQTPKALINFYKNWLLQIADSLIPCSVYDSLIHLHGREDAKPVNHDELVKILSSIPRANVSALVFLLEHISMVYGLSSIPSFGFCDDFPDELKPSTKESEVKEAVHKLNSMDAIGAVPFMHLIFRPSPIRSAGGLKPPLQVYNSILEGLLDLELRCDLFNNLVSNEKNYIERKQQERNNLGLQKKVSIPLSPRKPPIPTIGIMSPKALSASDSFSLRPFHTKVTPAPSPSASPRHLSRESHEHRDRSVSGTFLPPAIDVEFAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7B8</accession>
    <name>G3B7B8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4 16">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_98810</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="15">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="4 16"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7B8"/>
    <dbReference type="STRING" id="590646.G3B7B8"/>
    <dbReference type="GeneID" id="18250805"/>
    <dbReference type="KEGG" id="cten:18250805"/>
    <dbReference type="eggNOG" id="KOG2958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_0_0_1"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 16" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="17">
        <location>
            <begin position="16"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="18">
        <location>
            <begin position="212"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="342"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV61618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="377" mass="43278" checksum="88372D2FF9746820" modified="2011-11-16" version="1">MTVNTENGRAVANVPFDFTDHSHRRFNPLTNAWILCSPHRSKRPWQGAREEAKKTRLPQYDEKCYLCPGNIRATGDSNPKYEGTYYFLNDYPAVKLDQPDYSSEKSSDQDPKNLKSKLMKTQGVKGKCFVICFSPNHGLSLPLMSVPAIHKVVDLWQELYLSLKKDSLSGAAPYKYLQIFENKGAAMGCSNPHPHGQAWCLDVVPTEVQNELDNMGKYQRDNHSHLLGDYVNLELKEKERLVAVNDSFIVVVPYWALWPFETLVISREHLRSVEDFTEKHKTDLADVLKTLTTKYDNLFNTFFPYSMGIHQAPFKASEEEKNNSWFHMHFYPPLLRSATVKKFCVGFEMLGEAQRDITAEQAATRLQDLDGARHFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7T1</accession>
    <name>G3B7T1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_115778</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7T1"/>
    <dbReference type="STRING" id="590646.G3B7T1"/>
    <dbReference type="GeneID" id="18248009"/>
    <dbReference type="KEGG" id="cten:18248009"/>
    <dbReference type="eggNOG" id="KOG2892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_1"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="12">
        <location>
            <begin position="245"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="357" mass="39136" checksum="8A38CB6DDB3C5C20" modified="2011-11-16" version="1">MTQTPEVALPCPAGEIRIGGRKSELAVAQSEIVKSLIESHCPATSCSIVAIKTLGDVRLDRALYTFGGKSLWTRELEALLLGNAGNFKQIDLIVHSLKDLPTNLPEEFELGCITEREDPRDALVMKRGSPFMSLGQLPAGSVIGTSSMRRSAQLMMHYPHLRFESVRGNLRSRIRKLDEGDTFACIILAAAGMHRIGLKPRITQYLNSDEMYYSVGQGSLGVEIRRGDPRISKILAHIEHIPSAYRCIAERSLMRHLEGGCSVPLGVNTHYDETTKILSFKAIIVSPDGQECAEASIEMPIKCREDCVKAGIQLGDKLVARGGKKILDAIDYQRINQPPQSSSENSSLFTTSSPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B800</accession>
    <name>G3B800_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94582</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B800"/>
    <dbReference type="STRING" id="590646.G3B800"/>
    <dbReference type="eggNOG" id="ENOG502QPI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513889_0_0_1"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="338"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="492" mass="56206" checksum="1810B1CD9648F838" modified="2011-11-16" version="1">MTVQLTQENFEVTTDTVRGSDTLVSFSNHHHQDTEYELDQSESLTFLYNLLYDEQSQLTKSDILNILHSLKQREDSLPFSYMGANTNDIQGVDWPPGLKEKFYSDRRRIGSDKWFHNIPGSLDRAVNKVSILSSRSHTEFFKYHKFYSKLKLHITHFQLRNLTTNNFESTDSIHSYFKINRLSPDEQSNVRNSMQLDCVMDSRSLLRNSNSRISTLACSDKYLVSGTFEGDYILTDISDPQHFLHLGEHNLTRNYDGITNSIVINDNKQLIASSNDKSIRLVDLSTNHKTEIVLPFAGNCLAMNRFNPNEIFVSGDYLSSFILDKRIPLTKFEQVVQYKGQEDYSFSCDWSPTNENLLLSGNQDGNVRIWDKRFNEEPLFSWKGSLGLSSGDVVPGPVRNTKFSHKGQFVCWGESLDHVGIVNIDDLHSNTQQMDRIQSIDFIGKCTGLSFCETENGYGEQLIIGVNDCPLGGILSYSLESSEKCLDFDLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B809</accession>
    <name>G3B809_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115788</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688498.1">
        <property type="nucleotide sequence ID" value="XM_006688435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B809"/>
    <dbReference type="STRING" id="590646.G3B809"/>
    <dbReference type="GeneID" id="18248017"/>
    <dbReference type="KEGG" id="cten:18248017"/>
    <dbReference type="eggNOG" id="KOG4206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041869_0_2_1"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="107"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="180" mass="21073" checksum="2CBB638637313BBD" modified="2011-11-16" version="1" fragment="single">MSTIYINNLNEKVSANTLKRELQHLLKPYNVIDIHVKKTLRKKGQAFVSFKNENIDNIIRKLNNHVLLNKSIRVTHAKQNSYELLDQITIDSRIQVKKHKFFNTPSSMLILNDYNEDTISKDQILEVFDRFEGYLELRVIKNKKIVFIDFEKKEFAASCLNDVSLDDMQRIGGKLSFAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B862</accession>
    <name>G3B862_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_95247</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B862"/>
    <dbReference type="STRING" id="590646.G3B862"/>
    <dbReference type="GeneID" id="18250490"/>
    <dbReference type="KEGG" id="cten:18250490"/>
    <dbReference type="eggNOG" id="KOG2001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007738_2_0_1"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="50"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="457"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="841" mass="97950" checksum="7ABD668BD045A6AC" modified="2011-11-16" version="1">MDTPIDTVTLSNEPRLLQTCVIHDLRFQKARYHGLRDLTDINVQQALITKDLLFTLLGHEGQFIRLSDKYSARDLEVSIGGPEFKIAKNLDISLKLVTKKIIKFGRYYCSINNFLEHYDNESFGKAVQNLCHAIVAFKDKYEKVVIELENSFKYDASFNLNWFDNILNKQISSEMGHFYEIVNMIHNETLKRQREYFHNRDKYLDEYAQTQIGDDFHNPGSVDLFVDPIKFNVCKGGLVLQAIQQRIRAFKGDVVSTTFLTKLFEEVSKDYLNSLNEWLVNGIIDDPFKEFLIKQTSFQSFLKPSMQIYWDEIFKFRYDGLIDQLQSKDIQNKILLTGKYLNIFKHCTGLENFESFNENLMPIKSIFSQDFELKVDNFYKRANKLLMKLIFEGYNFNFVVEYYSKQFLLDNSSGVDNFIEANLNDLQRNKFKISISKLIKSFNNTLLSDENNDLSPLNKSLNSKLEFSINSLSFYDLAKEVLAVEPINAEDAIRDINRGETFEEIVHKNLDNKRQNIASAGSNISPESTGNFRYDPQNADQLTILGVNLSMDLQFPLNLVINYNFNLQYQLVFNNQLFLKFINKLIDNTWKEVSLSHVWNFPGFDRKISKWILRSRVLLNRMRDFVNELHYYISLEVIDKNHKELKSHLESVAHQLKEEPLESSFSEADASGFNGNSSFVKGMTNSYHELFNSKANNTNASPVDIIDLNNLSSKMATILNNILRDTFLVHEKVMNELQELLVLIVSYNQFLNKLKSSLIMMNDELFFQYKEAYPVYMEDKEINSNSVETIYGNLNDELIKYFEGFNNSLTRFMSSINSNLDNSSQQFLNLFQSLENCFPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3B881</accession>
    <name>G3B881_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_135650</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B881"/>
    <dbReference type="GeneID" id="18249895"/>
    <dbReference type="KEGG" id="cten:18249895"/>
    <dbReference type="eggNOG" id="ENOG502QS9Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012331_4_2_1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF14">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="623" mass="72351" checksum="4D7642F489ED0DA2" modified="2011-11-16" version="1">MSLPSRKRSRVPIACDRCKKRKRRCDGSQPCQSCARSNAECEYSLKSLLVQNGGSEAYTKELATVKQENLDLVEENRRLRSMVQSLESQQKQLQPFNPHDMVRGSNKLAETIFTEILSKVLFKTSGEENEYIGSFAVITIVKSIKTLLLGQEQEPEYLPIILDNVIGEEDFVPDRMETNFLDKFFSLAHNRGYFIDHVEFFKMMGKPVGERNSWEKFCWHMALAIGCRLVELLHVTTYPQPEVYLRRALKELVNANMNPLRQSQACLLIAVFISRSYHLSFYVSAWELTGCAIRKLVQFGYFRKQPSTLQNCWNYEFIKRMFWSAYNYDKLLSLSLGRPCSIVDNFVDLPYPISIDFPTRPVEADYQKLYQLQLQQQWEPNFKQSISGFTSFIATTNIRIIETRIHLLLYSVNNNFPIADTIETLKADIDNWYHSLPSRDEFEMVMNKRESYDFLDLSYYRARLILLLPLLMRSHNSERDSLLDQACLAAGKICSCYKKLYRDSILEFSIVALHTVFLAGITMVYYLKNKGEPTFINIQNDLRAGSSLLFVFSERWVEAKTYSDLFDSLLEDIDKIKNSPKESNIVDKADTTNPILDTFQTPNNLSEDFWDQILENIKHHNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8J6</accession>
    <name>G3B8J6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF833-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115200</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688812.1">
        <property type="nucleotide sequence ID" value="XM_006688749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8J6"/>
    <dbReference type="GeneID" id="18247766"/>
    <dbReference type="KEGG" id="cten:18247766"/>
    <dbReference type="eggNOG" id="KOG2342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047037_1_1_1"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="316" mass="35893" checksum="0AA1143E43778232" modified="2011-11-16" version="1">MCILLASTESPDYPFILLSNRDEYFRRPTENARFRPLSNRHILSPADLGRAEHGTWIGVDTTGKLAVLVNYRESDDLNVISEVSRGIIPVDYLSSDLSDEEWYDNLEKSLALRIVGKKVDSIPLRRVGGFSLLYGQLKLNDSGKINKLNIISNRGDKGTVFDFDSPPDHFHSNDTTIGLSNSLFYEPWNKVHLGRRALHEVINKSTEQHYTQQQLVEELFKVLSTNSYDQSFANKSMKDKLLGLRDTICVPPLETQFTDKELNDTIGKYYGTRTQTIILLDKHGVLHYYEKVLYSSDDLAAPGSGYQHFTVNVAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8X1</accession>
    <name>G3B8X1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_115237</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8X1"/>
    <dbReference type="STRING" id="590646.G3B8X1"/>
    <dbReference type="GeneID" id="18247785"/>
    <dbReference type="KEGG" id="cten:18247785"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_1_1"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="71"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV61798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="325" mass="36774" checksum="34218EEDCE205559" modified="2011-11-16" version="1">METTTLFLVAAAVITILVMVYSTALFFAHSPRLPTPSELKYRTNDANNQHYDLPTRIDPAAEYVDHGVKLTVVVPCYNETKRLGNMFEECVEYFKTHDLTYEILIIDDESKDGTPDYALSLARKYELKPHTVKVVELTKNRGKGGAVTHGMLHASGEYVLFADADGATKFGDSEHLLEYLKAHTNPYGSIAIGSRAHMVNTEAVVKRSFIRNLLMYGLHTLVYVFGIHGVKDTQCGFKMFDFNSIKRIFPHMHTERWIFDVEILLLASYQGIDMKELPVNWQEIDGSKIDLVKDSINMAIDLVVTRVSYILGIYKLNMNGHSKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9C2</accession>
    <name>G3B9C2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_125110</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9C2"/>
    <dbReference type="STRING" id="590646.G3B9C2"/>
    <dbReference type="HOGENOM" id="CLU_1521349_0_0_1"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="177" mass="20069" checksum="2377E7F0B6C0BDB3" modified="2011-11-16" version="1" fragment="single">MFSGSKLLGTPRGGNRNAGTRTQLEFTPIDLTLDNTDEFSIVGNSPFKPLNNTLFHRPMSGSEVVHEHAELINNGMTSIQEQQQQISRLNTENYNLKIEIKALRHYLNQIPEDQRSVFDLNIKLEQQLANAAKKIDSLSGEVRQLQATKSEAALNSKKEEELLDHMETMRSKYESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9C8</accession>
    <name>G3B9C8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_115941</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9C8"/>
    <dbReference type="STRING" id="590646.G3B9C8"/>
    <dbReference type="GeneID" id="18248091"/>
    <dbReference type="KEGG" id="cten:18248091"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
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        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPD_C_fung"/>
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        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="30"/>
            <end position="110"/>
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            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV62474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="159" mass="17221" checksum="E21876F830C0A3C2" modified="2011-11-16" version="1">MFRQTLRQVARQSASVARRTYATEATSDALKLSLALPHQTLYSDSEVEQVNLPSVNGDLGILANHIPIVEQLRPGLLEIISKGGETEQYFVSGGIATVQPGNKLTISAIEAFKPDQFDVNEVKNLISDAQKRASSSDEVEAAEASIELEVLEALQTIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9E5</accession>
    <name>G3B9E5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115314</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
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        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mRNA export from nucleus"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:proteasome assembly"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="DSS1_SEM1"/>
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    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="78" mass="9176" checksum="694DAB2EA8217836" modified="2011-11-16" version="1">MSSKSIENGVPTEDEKKVIKSLEEDDDEFEDFPADTKWTVKQDPQINPDSLWEEDWEDDDNEDDFSAQLKTELEKHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9I8</accession>
    <name>G3B9I8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_115349</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688867.1">
        <property type="nucleotide sequence ID" value="XM_006688804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9I8"/>
    <dbReference type="GeneID" id="18247831"/>
    <dbReference type="KEGG" id="cten:18247831"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="60684" checksum="77B09F4A33C2DFB5" modified="2011-11-16" version="1">MSHLATVTSHGLTSLRSRTENHINQVLSNRSEVRHVDAKEAADDEDLLAQIGYRQELSRRFSTFQVFGIAFSIMGLLPSIVSILTSGLEGGPASLVWGWLVSGFLILCIGLSMSVMSSAIPTSGGLFYWTNYYCPDSFRVPLSFVIGCSNSLALCAGFCSINYGFAFEVLAAVYINKDGDFTITNGKLYGVFAGCVISHVILCCLTTTHTAKLQSFSIYTNCFLIVLFFIAVPIGASKNIGFNDAGFIFGKIENHRTWNTGWSFMLSWMPAVWTIGAFDSCLHMSEEASNATRSIPVGINGSITVCWLVGFCICCVFAACIKDGDTARVLSTPTGSVGAQIILDALGKEWAVAFMSLIAFAQYLMGASTLIAASRQIWAFARDDGLPFVHKLVKKVDPKIKVPVNATIFGGCLSLILGLLILINSTAANALFSLYIAGNYLAWGTPILLVLLPFGAAKFEPGPFYFGKVITTSIHVITVVWIAFIIVLSMFPDNKEVDKETMNYTIAINGGVWSLTTVYYFVYGYKYYTGPKSNLEVVDAASGSDTDVQNIDEMIGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9M9</accession>
    <name>G3B9M9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_99046</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688100.1">
        <property type="nucleotide sequence ID" value="XM_006688037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9M9"/>
    <dbReference type="STRING" id="590646.G3B9M9"/>
    <dbReference type="GeneID" id="18250819"/>
    <dbReference type="KEGG" id="cten:18250819"/>
    <dbReference type="eggNOG" id="ENOG502S58U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104695_0_0_1"/>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="141" mass="15649" checksum="3EDC48AA786620B6" modified="2011-11-16" version="1">MSTLDTFISSTAKLLAAYPTTARVSITYANEHKKLERRTKNSKKPSEKSASNYVSFKVFEPSSGKVIKYKTYKVKELSKLITFLGPRGVTSNDAQKVPGLSSIMSNKKFDESEKLDTLVPAVPPSAETKDKKKKKKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9U0</accession>
    <name>G3B9U0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin GroL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_115422</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9U0"/>
    <dbReference type="STRING" id="590646.G3B9U0"/>
    <dbReference type="GeneID" id="18247862"/>
    <dbReference type="KEGG" id="cten:18247862"/>
    <dbReference type="eggNOG" id="KOG0356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_1"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="570" mass="60338" checksum="CCEBFA399F2EC11F" modified="2011-11-16" version="1">MLRASQPSFKRGTLSFVRNVSHKELKFGVEGRAALLKGVNLLADAVSVTLGPKGRNVLIEQQFGAPKITKDGVTVARSITLESKFEDMGAKLLQEVASKTNESAGDGTTSATILGRSIFTESVKNVAAGCNPMDLRRGTQAAVEAVVEFLQKNKKEVTTSEEIAQVATISANGDHHIGNLLASAMEKVGKEGVITVKEGKTLEDELEVTEGMRFDRGFISPYFITDTKSGKVEFENPLVLLSEKKISSIQDILPSLELSNQHRRPLLILAEDIDGEALAACILNKLRGQVQVCAVKAPGFGDNRKNILGDIAILSGGTVFTEELDIKPENATIDLLGSAGSITITKEDTVVLNGEGSKDNIQARCEQIRVAIEDGQTSEYEKEKLQERLAKLSGGVAVIRVGGSSEVEVGEKKDRYDDALNATRAAVQEGILPGGGTALIKASRILDSVKENATNFDQKLGVDIIKSAITKPARRIIENAGEEGAVIVGKIYDNAEFNQGYDSSKGEFTDMIASGIIDPFKVVKNGLVDASGVASLLATTECAIVDAPQPAGPAPAPGAGGMGGMPGMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9Y5</accession>
    <name>G3B9Y5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114819</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9Y5"/>
    <dbReference type="HOGENOM" id="CLU_3087050_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="52" mass="5604" checksum="4BB3490DEF5AC737" modified="2011-11-16" version="1">MFGLRNSAHTMIQTPWSNFIAQPQQETMGTAKCEIGSSVALRSTPVPLSVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAB2</accession>
    <name>G3BAB2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">37S ribosomal protein MRP2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_109296</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAB2"/>
    <dbReference type="STRING" id="590646.G3BAB2"/>
    <dbReference type="GeneID" id="18246098"/>
    <dbReference type="KEGG" id="cten:18246098"/>
    <dbReference type="eggNOG" id="KOG1741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_2_1_1"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00076896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="115" mass="13254" checksum="417651D7A1D0FD47" modified="2011-11-16" version="1">MPFRFPVKFEIPKHCYVNARVLKDQFKRIQYAEHEVTRNALKHIARNTELAGSVRLEAQLQLAAMPKYTSPTQIRDRCVASGNGKWVIKDFKLNRTAFRERARAGIIPGVTKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAV8</accession>
    <name>G3BAV8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114927</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAV8"/>
    <dbReference type="STRING" id="590646.G3BAV8"/>
    <dbReference type="GeneID" id="18247638"/>
    <dbReference type="KEGG" id="cten:18247638"/>
    <dbReference type="eggNOG" id="KOG1432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023934_0_0_1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="189"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="470" mass="53567" checksum="B1CE0769CE69F3B5" modified="2011-11-16" version="1">MPPPVNRLQRPEMEILNDNKVVTAVVVARQSRLFSSAASIGPLVPGEGETVESLWFHSSLMFNYYLVYKHKSIDVLQDHDEVVIDFNKGLAIRDTMSVDLGFGLWYNTISPAQLQDDIPVVRAIDVLYGLQTQLQDERPHWRHVPLNLDNLHFFKISAQEAAQYMPELKRIHNMKQGVLKASAHRFKMFQVSDLHFANGYVDSDTDKLISAGVAKESPDLIIINGDLVEFQSISRHQLTGVLLSALNVFIRQKVPFVVNWGESDYLSPDMVRSLEFVASLPYCINTIDTTRKIHGWTNYNYKIYADEEVLGVVSVLDSHQNNIKNNQINSMYRFNTPDLPIDTFKLAFVHYPLPNFRPVGKFAIVGDYNEKGPLNTSTDQTFINDFLMMGYNVISASHEHTNDGCIFHQDDSDKVLRSVWLCYSSVAGSQATAPDGFDRRLRVFEIKNKRLLSWKIVDGKGFHYSVIKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB91</accession>
    <name>G3BB91_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">CANTEDRAFT_114987</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687690.1">
        <property type="nucleotide sequence ID" value="XM_006687627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB91"/>
    <dbReference type="STRING" id="590646.G3BB91"/>
    <dbReference type="GeneID" id="18247658"/>
    <dbReference type="KEGG" id="cten:18247658"/>
    <dbReference type="eggNOG" id="KOG2631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_4_0_1"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="253" mass="28531" checksum="6D766D8F7FE82C76" modified="2011-11-16" version="1">MSDPQTIAKNDPFLDLDNPQHPANVICELCRLFYDNNWVTGTGGGVSIRDLDGDNKNLVYIAPSGIQKERLEPWEMFVAELPDETVLRTPNEGGYNKNYKYKASACQPLFMSCYKLRDAGACIHTHSQNAVMCTLLWEDKVEFKINHIEQIKALPRLQVNAATGKVEKVGSLENFDTLVIPIIENVPHEEDLVDDLEAAINNYPGATAVLVRRHGIYVWGENIWKAKVYNEALDYLLELAIKMKQNGIPTIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBK6</accession>
    <name>G3BBK6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_108530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBK6"/>
    <dbReference type="STRING" id="590646.G3BBK6"/>
    <dbReference type="eggNOG" id="KOG4173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092647_3_2_1"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="135" mass="15847" checksum="AF506431B482130E" modified="2011-11-16" version="1">MSKRRRSEELLPSTTSATVPTIVCTLGYCVQAPPEFSSYPEYELHVQTHHTHICHACKKRFPSAPILSMHIEEKHDPFFVIKRDQGLKVYKCFKSYNEINPCHKVCSDRKKRRLHMIDKHGYPRDYNFSIIDRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBM9</accession>
    <name>G3BBM9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115040</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBM9"/>
    <dbReference type="STRING" id="590646.G3BBM9"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_8_1_1"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="243"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="637" mass="68947" checksum="7784805E3BD50508" modified="2011-11-16" version="1">MVWDATDVYDNEQLVAKLAANQRAQNFNDNEIVSKIPTLRSGVGSGGISLTSEPEPYDTVSISLNAGGRQSFLDAPIGSFRGPNSLHNFASSFTRAQSYAASKLDSEIHRQRSFFHREDENGAEPDELFDPELMIPSQRGERLSTVVHDVNVARNNLFSYDSFAPITDVFYQDDILSALNNSRSRAGSSVVAQGIPIPQRRMYPSPSFSSIRSSLSMATTASHVNLKKIEDKDGNVVTVLAGQSTAPQTIFNSINVLIGVGLLALPVGFLKAGWVIGVPMLLVCGLATFWTASLLSKSMDTDPTLMTYADLGYASYGSAAKLLISLVFSVDLVGAGVSLIVLFSDSLYALLGDDEVWTKTNFKILSFFVLTPFTFMPLPVLSIFSLLGIISTISITGLVFVCGLLKASSPGSLLTVMPTNLWPDSWSDLLLAIGILMAPFGGHAIFPNLKSDMRHPYKFTGTLKVTYLITLITDFTMGVLGFLMFGFYCKDEVTNNLLFTPGYPSFIYPLISGLICMVPIAKTPLNAKPIIATLDSMFHTNTISENQLGNAVRTVGRFLIRVGVNAVFVGLAIVFPEFDKIIGILGASICFLVCIILPCLFYLKLVRIGGLEKSMVLLVIAVSSGLAITGTWAVIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBP7</accession>
    <name>G3BBP7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_136140</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBP7"/>
    <dbReference type="STRING" id="590646.G3BBP7"/>
    <dbReference type="GeneID" id="18249941"/>
    <dbReference type="KEGG" id="cten:18249941"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778499_0_0_1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="352" mass="39913" checksum="A2C78BF9558B136F" modified="2011-11-16" version="1">MSTAIYYNPEERHSLPSLSSIMNTQQPQPTAAGPAATSQLQPNGSISGQSVSGDSELFSTAGSQTSTAHTTPASSFSGSSSGSGQYYGEGKCSCKSNANRIPRPRNAFILFRQKYHQSVLDEGSVIRTNPEVSRELGRRWRALPNEERDHWNKLAEEEKTNHAKKFPGYRYTPRRNGKGKICDFCKQKNLRQQQLQLHNHQMLQLQQDQYTSYMLQQQQAMQQLVPSGQNLPPQFNQQYQQTPQSSNVNLQQPYNNMVYLPQNPIQSNFQFQYNNEFVPGTQEKLSPLSSMPMPYDHHYHHQQPSQMPQVQVQQGQPQQQPQFAIGYEQSRFNSLPTPVGTNASGYGFDYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC02</accession>
    <name>G3BC02_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vhr1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_132440</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC02"/>
    <dbReference type="STRING" id="590646.G3BC02"/>
    <dbReference type="GeneID" id="18249623"/>
    <dbReference type="KEGG" id="cten:18249623"/>
    <dbReference type="eggNOG" id="ENOG502QVE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006698_1_0_1"/>
    <dbReference type="OrthoDB" id="4089008at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007147">
        <property type="entry name" value="TF_Vhr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04001">
        <property type="entry name" value="Vhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="232"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="558" mass="62370" checksum="34CC006741697CF8" modified="2011-11-16" version="1">MTEEEQYRRLGVTHAIRDKLDFHDERRWKRFSARRLELIDTLDLSSKKASEQEANITKVAEALRIEFEYSSEYFDEFDRLVRAAIQSVRRNRKRSSKSKRSQDKLAGKIAKVKHESFDGGSSNTDSFNSAQDDNEFVSEYTKFNSDSQDDTNEYSKSKHISNYDQSRAAIVSMVQPRVGRQNSNFLGAKLPSFESLSAVSSLAQISSKKAVLLNYIERSKSCAEATVKKTANLEFLGRGIIIASVGYVFERSFASTNEKSLDYLRGKLVQESYLADFFRNLETLPNKDVSLNDEAAVTTLYALLGGCIKDFGFEAIMFPLCELLYWNIIREYPLIAQSSVPFRSTDSMGPTSQPSPEIQKSDSFLQLESLAAVASQVRKQEQVPPALRSLSVSPVAGKVQGKKAVALRFLSQTLNFTFPTKVSATPKLDELLENARSAFHLSSYGDSQVLGLKNMKDGFILKSDADVERVFTSEDHIELEIFTQKPQAVPIYEITSLNIPNGYILPPPVPGGGRINSRSPDTVPTLAGGSFKFLSNQDDHPPPHIPPVPILPKFQPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC03</accession>
    <name>G3BC03_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116819</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC03"/>
    <dbReference type="STRING" id="590646.G3BC03"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000152">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF74">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-LIKE PROTEIN OCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="241" mass="27861" checksum="8F146FA992A22EA4" modified="2011-11-16" version="1">MARVSEANTIPTSPDRDAYHDNGLKLPADGQLDNGVPVFTANARPPLVPPLNFSLVEDRIYRSGFPNPLNYPFLKQLGLKTIIYLGDLGQEVKKTPKQPKEQKEKKVKKDKHTKEDIWNEYNAWIGTTNIQFHHLVMESSQEPFTSLQEQQQARDSLRTALQLMLDKNNFPMLIHSNKGKHRIGVLVGLMRKIFQGWCMSGIFEEYEKFALGKSEFDLEFMELWQPELWVSQDSRPEFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC45</accession>
    <name>G3BC45_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c oxidase polypeptide IV mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_116847</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC45"/>
    <dbReference type="STRING" id="590646.G3BC45"/>
    <dbReference type="GeneID" id="18248472"/>
    <dbReference type="KEGG" id="cten:18248472"/>
    <dbReference type="eggNOG" id="KOG3352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091071_2_0_1"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="158" mass="17240" checksum="1FBED24115441020" modified="2011-11-16" version="1">MFSRAIKQSFASLPRARTLTSSARVFSAPVKTNTPTAKTLADVTGPDSSLIGPGATPGTIPTDWDQSTGAERFELLGKMEGVDVFDMENPIFEGSGTMQDPYLVPTYVGYRYVGCMGKKGEEHKPYWLKVTADEPARCWHSGVVFLAKYVGSPEHAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC53</accession>
    <name>G3BC53_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTEDRAFT_110563</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC53"/>
    <dbReference type="STRING" id="590646.G3BC53"/>
    <dbReference type="GeneID" id="18246202"/>
    <dbReference type="KEGG" id="cten:18246202"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009279_1_0_1"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="21">
        <location>
            <begin position="23"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="22">
        <location>
            <begin position="536"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV60790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="740" mass="83584" checksum="EB58966A7D857948" modified="2011-11-16" version="1">MSTNTKLQSQVLGIPIDTIRLLLQVLIFVSVAGAAISSRLFSVIRFESIIHEFDPWFNFRATKYLVTHSFYDFLNWFDDRTWYPLGRVTGGTLYPGLMVTSGVIWHVLRDWFSLPIDIRNICVMLAPAFSGLTAIATYALTTEMKDSNAGLLSAIFMGIAPGYISRSVAGSYDNEAIAITLLMATFAFWIKAQKQGSVLYGTLTALLYFYMVSAWGGYVFITNLIPLHVFVLILMGRYNHRLYTSYCTWYAIGTLASMQIPFVGFLPIRSNDHMAALGVFGLIQLVAFGDYVKSQITEKAFKTFLVVSIASIVSLGLGGLVGLTALGWIAPWTGRFYSLWDTSYAKIHIPIIASVSEHQPTAWPAFFFDTSFLIWLFPAGIYLCFQELKDEHVFVIIYGVLCSYFAGVMVRLMLTLTPVICVCGGIAVSKLFDAYLDISDLFTGEVVEEDSKKKGSKKKPASSATIFKILSKVLVLTSFAYYLFYFVYHCTWVTSNAYSSPSVVLPSRNPDGSPTIIDDYREAYYWLRMNTPEDAKVMSWWDYGYQIGGMADRTTLVDNNTWNNTHIATVGKAMCSSEEVSYEILKKHDVDYVLIIFGGVIGFSGDDLNKFLWMIRISEGIWPDEVRERDFFTDRGEYKVDQSATETMKNSLMYKMSYYRFHDLFNGRDGIDRVRSQTIPIANAPELSVVEEAFTSTNWIVRIYKVKDLDNLGRDLKQVSAGSKTKKSRIIKKPKISLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCP8</accession>
    <name>G3BCP8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 11">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_132499</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 11"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCP8"/>
    <dbReference type="STRING" id="590646.G3BCP8"/>
    <dbReference type="GeneID" id="18249626"/>
    <dbReference type="KEGG" id="cten:18249626"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000044">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="249"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="591" mass="67906" checksum="420888C76F63181A" modified="2011-11-16" version="1">MSEEVSQVTDQLQKTYLDEVTGDYVSKSELKKRQKTRAIEAKKAEKAAKNADKPKPVKKDQLADLNPNQYYEIRSRQVKELRQKNLDDPSAFNPYPHKFNRTLTLPEFLKQYGHLNRGETLPDVEVAVAGRIMSKREAGSKLKFYVLKGDGIQVQIMGQAQDAPSDESYHEMHELLRRGDIIGVVGYPGRTSPAKGGDGEISVFAKTVQLLTPGLHMLPTEFYGFKDQEQRYRKRYLDLIVNDDVRERFKVRSEIIKYIRRFLDTRDFIEVETPILNVIAGGATAKPFITHHNDLNMDMFMRIAPELYLKELVVGGMDRVYEIGRQFRNEGIDMTHNPEFTTCEFYQAYADVYDLMDMTELMFSEMVKSITGDYKVTYHPDGPTGEALTLDFTRPWKRINMIEELEKVYNVKFPPGDQLHTEETGKFLKQILIDNKLDCTPPLTNARMLDKLVGDLEDSCINPTFIFGHPQMMSPLAKRHRSIPGLCERFEVFVATKEICNAYTELNDPFDQRARFEEQARQKDQGDDEAQMVDETFCNALEYGLPPTAGWGCGIDRLAMFLTNSNTIREVLLFPTLKPDDFVKGEDRSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCT0</accession>
    <name>G3BCT0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_128585</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690091.1">
        <property type="nucleotide sequence ID" value="XM_006690028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCT0"/>
    <dbReference type="STRING" id="590646.G3BCT0"/>
    <dbReference type="GeneID" id="18249319"/>
    <dbReference type="KEGG" id="cten:18249319"/>
    <dbReference type="eggNOG" id="ENOG502R6C6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548738_0_0_1"/>
    <dbReference type="OrthoDB" id="4025621at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="450" mass="52235" checksum="B2530DEFCDC7B46B" modified="2011-11-16" version="1">MNRYQLIGRKTKVNRPQTPDYGPLSLHSMPPEILIKIFSHFKNDTLELINISLVCRKLHNIIVKNFLYKDVRFKDTNSFLKFTHAHLPNKRYGVSETSTHVNLIRTVEFVNPPVQNSQNSRTNIAGSYSVNVVISNNSVTNFNDFVSGVNMLLKENYNLKTIIISEISPQFLFNNISVDTSLLKKYKKRQNRTLHRLVIKAQTGWSILFRVNHISKILDIFDSVDELELHNFIIDESKLVGLSIPKTVIIHQLSLVSCSFTNRCQKRTPSELLKSTSSLRLENLTNNSDLSVIDMVKCNDMLETLIMDMDSKLFYENGSFNFKTFNPFFKLLCSGSGYFANLKCLVFDNFDILYQYNHNHKNEENDRHEENTLTEFLNHISKTKYLIIKVKDMPRTIHTCKNCGFMKTQDGISIENLSKTDWRTLVWPLIEAKTKFRIMSFKGMILYEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD32</accession>
    <name>G3BD32_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_110406</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690122.1">
        <property type="nucleotide sequence ID" value="XM_006690059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD32"/>
    <dbReference type="STRING" id="590646.G3BD32"/>
    <dbReference type="GeneID" id="18246192"/>
    <dbReference type="KEGG" id="cten:18246192"/>
    <dbReference type="eggNOG" id="KOG2798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030612_1_2_1"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="391" mass="45348" checksum="19D1B9EC08ACEA66" modified="2011-11-16" version="1">MDDIEEYKALTSVFSAYYHFHQWEYDQLIKPRGIKYNSLPPDEQRLLPWYTQHTESLKQAINTNKQFTQFVALTICKQFGIEESPSSWYEAGHDDFDKVRSILLQLKREWGDEGEHERLVFERMICELNHKYPDFSARQHVNVLLPGCGLGRLVFEVVRNGYRAQGNEFSYHMLIMANFMLNFCSHPFQIHPYLHKFSNVCNRADQLRSVVILNHAGGTNGFEQLMLAHPDVPFMELMSMAAGSFTDLYGPDSLTTNSTSPNEFRATNKAHFEAVLTCFFLDTASNIIEYLKTIAYCLKKSGIWINLGPLLWHFENDFNTSHITLPSGEQVPTIMKGLELSRADLIQLIEDMGFQFEKMDTHEQRTVTIYAADPRLLSNFTYHCEFWICSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDD6</accession>
    <name>G3BDD6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116997</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDD6"/>
    <dbReference type="STRING" id="590646.G3BDD6"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031567_2_1_1"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="224"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="430" mass="49281" checksum="AE4FFECF161A92A6" modified="2011-11-16" version="1">MSTLSQYLSHIDTAIKTQDSRQLSTLIEINPPNGQGPVRSQFQDPNDFDLFAVDEKFRPVVVAYLKLLKAIYVVNDIKKSFNNYIELVNTLNRAANTETNWINLPLMKACKELMDIFGVMEKSFPEEVQAKQPDSEFQTSANSSSLEILASTINNSFKLSLNDKNLDLKQSKRVDIYFFLGCLLRLYFRLNTLDMAKSVEKALKGTRFELPKFDKHLVDKSSAITYLYYSAILSLDDSEFNAAHEKLEQAMSLLAYIKKRTSVESQMEKLLVLYLPLTLYTQNKYPKPFIWKEFPILNYIYNESSFNYIKSGDVNKLNWFIQKFESFLLKKKLYLLFESLKDLCYINLLKKTVKIHAFITDSKGSHIVPFSAFTVSFNLSNSTGQETFNKQEIECILAVLISKGRIKGYLSHGNGCIVLSKTVPFPPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDD9</accession>
    <name>G3BDD9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA polyadenylation factor FIP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116999</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDD9"/>
    <dbReference type="STRING" id="590646.G3BDD9"/>
    <dbReference type="GeneID" id="18248535"/>
    <dbReference type="KEGG" id="cten:18248535"/>
    <dbReference type="eggNOG" id="KOG1049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039307_2_0_1"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="7">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="263" mass="28634" checksum="5DE313E30B817D9F" modified="2011-11-16" version="1">MAKSDDDDAYLYSSEDDGQPSTKKQKVNGTTKENPAKDDAAATRPSQSEDEDDDDDEEESSDDDIDIVIGDNTTSTSRPSTASTSVTTAPTSESTESTTQPTSIVSNNQKESLDINKVVELDGKPLTQVDLEKLKDKPWRIPGADISDYFNYGFDEISWTAYCCKQDKLRGEFNPAKLMAQIMGGSKGKNGPPMPPMGMPVPPPGMPMGMPPMGMMPNMPNMPNMANMPMPPNMPNMPNMPNMPRNMNFGKSNLPPPPPPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDF8</accession>
    <name>G3BDF8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_116344</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDF8"/>
    <dbReference type="STRING" id="590646.G3BDF8"/>
    <dbReference type="GeneID" id="18248257"/>
    <dbReference type="KEGG" id="cten:18248257"/>
    <dbReference type="eggNOG" id="KOG0063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017344_3_0_1"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="93"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="364" mass="41023" checksum="A9197E9510343AC1" modified="2011-11-16" version="1">MFDEPSSYLDVKQRLRAAEIIRSLLDTTTYVICVEHDLSVLDYLSDFVCILYGAPSVYGVVTLPNSVREGINIFLDGFIPTENMKFRSESLQFRLADAADGLILDKSQALQYPKMQKSQGDFKLTVEEGDFTNSEILVMMGENGTGKTTFCKLLAGLTKPDNNQDIPKLNISLKPQKIAPKFPGTVRQLFFKKIRASFLHPQFQTDVVKPLKIDNIIDQEVTTLSGGELQRVAIVLALGVPADIYLIDEPSAYLDSEQRIVCSKVIRRFILHSKKTAFVVEHDFIMATYLADRVIVFEGQPSKNSLAKAPESLLTGCNRFLKNLNVTFRRDPNSFRPRINKLDSQMDKEQKAAGNYFFLDNSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDI1</accession>
    <name>G3BDI1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_95755</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDI1"/>
    <dbReference type="STRING" id="590646.G3BDI1"/>
    <dbReference type="GeneID" id="18250537"/>
    <dbReference type="KEGG" id="cten:18250537"/>
    <dbReference type="eggNOG" id="KOG2710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016108_1_0_1"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="131"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="605" mass="68047" checksum="94B210C6D6BD847B" modified="2011-11-16" version="1">MSHSSSPNNRNSIFGWVKNLKNKNLLSNESVNEISDNDIMSSSDYKYSDAENIPSSNQNSYNQEFLRPSLNHKSRSANNVNRVRSHSQSDNNSAINHFGNTPNPNASIRQHRDSFLLSNPLVDKNSKYFGVPLEEAVNQACAKISIFAENDSGEVLQYGRIPVVVAKCGVFLKTNGLSVEGIFRVGGSSKRLKELQVLFNTPPDFGKKLNWDGYTVHDAASILRRYLNSLPEPLIPLELYEIFRAPLRSRARIINYMKYKASNPKKLLKSKMSPTLVEAADTPVEAFKLNEFNSNVTSNVTQTPKTVDTSNSLPSPSLSPDNYHDEVMGGSISLDNRMDTIESVGKHEVFGDNDEENDADNDDDDNDHNNVNSDNENVNYVDNDGLVKRNEEMVKMKQSKKNKHYKKLTKDVHDAIDEYKVMLDQLPILSKQLLFYILDLLAMVQNHSSENLMSSRNLAAIFQPSILSHPNHDLDPTEYALSQFVVEFLIQYAYKLLPNHDNLSRPISKSPVSTTSVNKLEGDKHKLAPRFNRQHSKSLSSANHEDVVGYQNKVSNSKLPVVDKDYEIAEDDSDHEEKEKFKEREPSSQPAIIVSTPSSSSVPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDK8</accession>
    <name>G3BDK8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136804</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDK8"/>
    <dbReference type="STRING" id="590646.G3BDK8"/>
    <dbReference type="eggNOG" id="ENOG502S25J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415057_0_0_1"/>
    <dbReference type="OrthoDB" id="4096963at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="67467" checksum="9B5D1CC514A33B7A" modified="2011-11-16" version="1">MESNTPIVPKRPNKSALIESNSLEEYVESDTLVSIEGSSKDSESPSTPRVPKRPIKPDPINADSANSFPLVSQRSTSHEEGQLNSVANAEGDVNEIEEVDNDDNDGDGDKTPGNSNTKISFKDDMPSDVDNLVGTDTSSFDDDQETVSQEKEEQLESNESHAPENMTKESIIASNVMPIIPKRPAKFALPALDDSLSAKESSKETDGDIMPIIPIRPMKKKENQTDSKEVQSLASSGHISIDDSSSNVSVETSKDSKSLETPLDHPPEDENHEAANEQPISKASSETKEVVTAADSVHLVQVKPIIPVRPKPKVKSSSDATSVVSSSSEGPINERKAPPPKPKKLSSKIAAFQEMLNKAPSIGALDSNSGSVSRGQLSNSHIKFAQNLQGIVGKGFALPGMVDPSKDTLPIDHQRDTIEAKILEDPHEVNEYGSEAQKVSTRRAKGPRGKKLPKILSTPLSIRSESKFKIVEHNLWSVELKRITPVETLRVSKASSLSMVTEINERTLESQNSSSEVNVPNEKLNEPHEIAKEVHESSKKSEKDAIITDRIPESDEVETEGAHLCLLHSKSPHEKETEEVLGAPEELKQDYPTCKENLISNEEKETSVSANSITEKFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEF1</accession>
    <name>G3BEF1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_95980</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEF1"/>
    <dbReference type="GeneID" id="18250562"/>
    <dbReference type="KEGG" id="cten:18250562"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012768152" description="ferric-chelate reductase (NADPH)" evidence="18">
        <location>
            <begin position="16"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="416"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV60530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="731" mass="82852" checksum="C2A16A6C7ED57CB9" modified="2011-11-16" version="1">MKFWTPLLLAVPALCDDVSLFEWISNYEIALESCQAQIDLTATVCLIPETAAKRGLVRRDDDFDPTSCYCTMEAPFVTLIDCFVKGEGNKTSYMNSFIDSCKGLTDEPLTLDSLYSTYYSGLKHMKNVSTVENFSLTEVVDYPVLLDYKQYKINRQWEWMAEKNKNLGSIFGLSLMGYWGLVLLLATLVNWTIYLFPGFTGLFVGPLSNMWRKYVSLPAAISRRKTRAVRFGLLVPSRMESLIIFVFLFLTAMFSGINIHSVPGNEFSQGNYVARFVAIRTGIMVGYICPLLVLFAGRNNFLQWLTRWNFATFITYHRWVSRIVVLLVIIHAIGFTVSDISRDKYSARVKEGFIQWGIVACVCGGIILVQGLLVVRRKSYEAFLVIHILMAMFFVIGGYKHTLGFGYQPLYWTSIAVWAIDRLIRFTRLFVFGAPMATVTLLAEETLRVVIPKPSFWHATPGGHAFVHFIRPSCFWQSHPFTFTDSSEEGNYIVMYIKLKGGVTHGVYKHLANAPGKSAKIRVLVEGPYGEDSSARKYKNAVFIAGGNGIPGIYSECIDIARKTVDGNGPRLKLIWIIREWKSLAWFYQELRNLNNTNIDTTVFVTKPLLNLENGLTHLKPILIDSESSYSDKEKTNSDVKDSSLPCNDSDSEETSMVASIKNELSHISFQEGRPEIHDLICNEISQADGSLAFVTCGHPHMVDEVRFEVSQNLHQSKHRIEYFEQLQVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEU7</accession>
    <name>G3BEU7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_132319</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEU7"/>
    <dbReference type="STRING" id="590646.G3BEU7"/>
    <dbReference type="eggNOG" id="KOG3098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="477" mass="53620" checksum="314A248A4BC6F290" modified="2011-11-16" version="1">MSDLESKQESSLRWYDRKILPFMPAYSSSMFQVVVLSLVCFMTTGMYNALTGIGGSGITIGVANNGSTALYIVFCVWGFFSGYLCNMIGVKLALCIGSCGYCLYSGALSTNPGGAEAFIYASSAILGACAGTLWSAQGSIMMSYPPEEKKGRAIMIFWVIFNLGGVVGSAISLGNNLKNNESTATDSTYAVFIALMGSGLLFALGILPAHKVWKYDVGEERVVSYQYPHWKSELASMFRMLYKEPKIYLMFPMFFASNWFYTYHFNDVNAARFNIRTRSLNSLLYWLSQMVGAFGFGLVLDWERFNRKTRTKIAWGILMALTLAIWGGGLKFQLQYTRESVMHMELYDYKHRAYIGPMFLYIFYGMYDAIFQNFIYYLLGAISNNPKKTAIYGAFYKSIQSAGAAIMWRLDYYEIPYINMFASCWALCAGSVMIAFPLAFFMIQNHTDVEDDDLNGEMVMKQADISCIENTSSTTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEX4</accession>
    <name>G3BEX4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115984</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEX4"/>
    <dbReference type="STRING" id="590646.G3BEX4"/>
    <dbReference type="GeneID" id="18248110"/>
    <dbReference type="KEGG" id="cten:18248110"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024937_0_0_1"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="499"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV59960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="690" mass="79496" checksum="9C032F59AD62E4AD" modified="2011-11-16" version="1">MDESTSEEVELPEELNMDAFDKVTAEHLSFVEFFSPYCSHCKQLAPKWEQTYKEFRQELTELEVQMRQVNCVESADLCEREEVFAYPNLRIYAPIHDRQTGLKTGKSKFVTSYPRSLVRTPENFKKFVKNAVAEYSSGAIDLPSASKELDLDNVLKYIAGDVQQPEFVMFHPGTEKQWKVSDTTGKSAFAKGCYDCMDNKQIWDKLSNQVLTTVGTSHFSCGSNKELCAKLGFEKLADSKTASPEFVMFLPKATGTIRFDFKGFITLEALKKFASDLYENHKFEIVSAKTLSEIMEFRKSLPNEPLYSYYPLQNKVSIVFYYDPKTVAAEDKDILPYLLDFATYSPFNMYIYTTKSDKFERAIGSQAQNMVNFINFDEKEDKKTFNKAMHLATTLTTKPTLFIIKDNTLFTPIFQSYAPEDIRNKDKVLDFVARNQFPLYQELTPELMPLYFDKKNGNNQDKVVVTFVDSSNPQKTDEIFYQISLVAHQYQYVKNEYYFNDILEKRGQKEERVNELKKQNADSVQIIKAMRKEVPHLFDTNQVLFTFIDLTTNPNLAGYHGWNVNSREYAVGDTIVVTKDNTHYWDQDLTGEPLKTTPEDFSLVLKYLLDPQLVSHRVDLNLVNLKNYLVGSPYGASLRFMDVVHERGFAGYLIVILAVFGTVSAYLRFKKRSRRTTSSMGIIGNTEKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF80</accession>
    <name>G3BF80_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116719</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF80"/>
    <dbReference type="STRING" id="590646.G3BF80"/>
    <dbReference type="GeneID" id="18248419"/>
    <dbReference type="KEGG" id="cten:18248419"/>
    <dbReference type="eggNOG" id="KOG3308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058668_1_1_1"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="244" mass="28219" checksum="50CC93BFE698AC46" modified="2011-11-16" version="1">MENKNNEVSDLKIIIVGISGPSSSGKTTVTKNLLNLLDCQILHQDDFYFPDDQIPVDHKTGEQNWDHPDSIDFDKFITYIQKVKAGEEFPEKIDTLEPDINLKLSAQEITELKAKLQNQLKGVKIVLVDGFMLFHDKTLVDLFDLKLFYYSTYDCLKSRRANRKGYSTIAGFWVDPPNYFDDYVWPAYASFHKHLFTHADVNNTLNEHALVDLKIRAYKNDDNSNITEMVSWSIEQILDYTRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF98</accession>
    <name>G3BF98_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_110649</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF98"/>
    <dbReference type="STRING" id="590646.G3BF98"/>
    <dbReference type="GeneID" id="18246211"/>
    <dbReference type="KEGG" id="cten:18246211"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_1_0_1"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV60005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="591" mass="65260" checksum="7558CCFF74166559" modified="2011-11-16" version="1">MNYFHPDAAKDFLKAKVYGQPYMPRDTSELLFLLRIQARSWLLFVVSQFKLKYSSDPVWGPTFLLRDSVFIYVVYLYLCKAQRHVCGYGIIGTLGAIKTQILRTTFSIVLILPGVKSKVDKELQKTVAKIEEMVILNDQELLQLPQLPQNGLPDARVLVELDKLQTLKHSDWSNGRVSGAVYHGGSELMSLQSDAYRKYSIANQLHPDVFPGVRKMEAEVVAMVLKMFNGPETSCGSTTSGGTESLLLAGLAAREFGKRAKGITSPEVIAPMTIHAGIEKACYYFGMKLHKVDLDPVTYQVNLKSVKRHINSNTVLLVGSAPNYPHGIIDDIEGLSKLALKYNIPLHVDACLGSFIVSFLEKARVHEKVPLFDFRVPGVTSISCDTHKYGFAPKGSSIIMYRTNELRKCQYYVSSEWTGGMYGSPTLAGSRPGALVVGCWATLASIGEDGYTQFCKDIVGAMLRVKRAVKDNQTLKENLVVIGNPLASVVAFKARNKNFSIYKLGDMLTSKGWHFATLQHPAALHFAMTRLTIPIIDELINDLTECTKLTAEDESSAESDTAALYGVAGSVQTVGVADKIIEAFLDAMYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFE2</accession>
    <name>G3BFE2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U6 snRNA-associated Sm-like protein LSm2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_128123</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFE2"/>
    <dbReference type="STRING" id="590646.G3BFE2"/>
    <dbReference type="eggNOG" id="KOG3448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130474_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="115" mass="13211" checksum="4888D5A6D9903726" modified="2011-11-16" version="1">MLFFSFFKTLVDQEVTVELKNDMEIKGVLKSVDQYLNLKLDNISCTNDVKYPHLNSVKNLFIRGSTVRYIHLNPNSVDCTLLQDASRRGPWFKPPSKGCPLAHTKLQCIIDRLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFN0</accession>
    <name>G3BFN0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_136559</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFN0"/>
    <dbReference type="STRING" id="590646.G3BFN0"/>
    <dbReference type="GeneID" id="18249982"/>
    <dbReference type="KEGG" id="cten:18249982"/>
    <dbReference type="eggNOG" id="KOG1842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026440_1_0_1"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="330"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="630" mass="72435" checksum="E5AEEE8FF6327ECC" modified="2011-11-16" version="1">MTAKTKRRVLGTVQQAPTTANGSTKLPIQSGEHPLPVPQPVMTSPSPIAHTGPDSLICPICNEKMISVNQLNQHIDDVHLGDSNSDSPPPPTAMPTTPQKLDSPGVLDKIIKRNTTPTKKIINLDLFEGSKTFSLSDSNGRDANSMSPTLHQKPRVSRTHWVQPSGNNTCSMAGCSKQLNVKNGIVNCRRCGKLFCNSHTDFKVKLRNPNPGESIPQYDKDGIWSKCCEECFFHKPDIVAGTAVNAVDLTSSFRQLRQTRQEENQLIIDKTVKKFIKLVNLLTEFYITSQHHREAPRTGLSSFFQTSTLDESLLIEKQREIVGYENWQDQNLVQYCYICLTKFGFLLRKHHCRLCGQVVCDDKFSERQECSLLVPLPMILSKLTHLNYSVQVKTHFDEVLHSHDDLFSVRMCKNCKDSLLYDYKLKILNEQHDPKLQELFSYYNQLFVVKEKIHHQMAKYRREMDAVTKSKSNAALESTNRFKDRVMGSFREFERILTEFKTIYFVQNSVSPQFQKYGRILKGINQSLILFLQESLMEFKDLNNRLKQTENEAMPKQPEVEIPRLTKKQIRELRESLMVMNEQKFIIEKLINDVTKQRKFDELQPLLNNKLEITTEIDRLESELGEFGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFP3</accession>
    <name>G3BFP3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_111855</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFP3"/>
    <dbReference type="STRING" id="590646.G3BFP3"/>
    <dbReference type="GeneID" id="18246316"/>
    <dbReference type="KEGG" id="cten:18246316"/>
    <dbReference type="eggNOG" id="KOG4151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357916_0_0_1"/>
    <dbReference type="OrthoDB" id="5574718at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="3">
        <location>
            <begin position="135"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="796" mass="88696" checksum="CBD3EE503166D643" modified="2011-11-16" version="1">MNEIHTQLENLALDDFKKAVQVFEDPTGAGDAATADTLLKYSQSPPTSAVLLQLLRSNITKFLKGLHAIHDDHGAILVNLLSGCSDEQHLTAQVLNSIKLVLKNTTSSTKTSWIDFNLKVYLGLVSEFGVVFPAHLPVLLAYLAPEEESSDVNAVLLFIVVKNIELKQQESFDAIDGFFDYTLETGAGTKTFLAFVKALELLFPICPSVCTRVYTSSLCRDLVLEHVKTITPSSLSLPNPRATADGLLRLVSSSCIDDDCRKFNANIYLDLLKVGSGLDANQYPLFKILSVLCIVKLWNFLQLEADSSFSFSMDGLFDTSIEYLRKENEGLGTAIEALAYLTLNPSLRNRLRADESVVDCLVQLIGRRTEVKDQSLKNDHSSTVYGLLLILSNVTQIKESSQSQETNTVNYLKSVATPKSTTDTTKENTEDILNFNKSLLLDHSIIDTISKLKIIRATTKKGSNNSDQFVNIIYYISLNQEKKVRQELVKQGSLNILLDYLVSHSQVLQKQSGQTRPISSSDSLVETRLRAIRALCKILISVNPALAFNKYSVVTCLPFLVELLGPDISTYTGKLQSNANDAYLHDNVTSLDKYESLLALTNISSMADPKDEIKDSIITKTFDKFLNNFIIEGDSPLIQTAAWELISNLIMKPRMLVKFFNADDQQSLKRLDILIKMLESKDIHLQTTLAGLLANATSEFDMIPRLLVEVDHLRKELVVSFVRIFNSQSDDDDLILRLVYVVLDLVYAAANIGETQIAKFKHDQALKSALAGVLKNNRNEQILEVVVEIIKFTKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFV1</accession>
    <name>G3BFV1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_109914</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFV1"/>
    <dbReference type="STRING" id="590646.G3BFV1"/>
    <dbReference type="GeneID" id="18246151"/>
    <dbReference type="KEGG" id="cten:18246151"/>
    <dbReference type="eggNOG" id="KOG4655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="183" mass="21566" checksum="D92822802F11AB9E" modified="2011-11-16" version="1">MVRALKYHEKKLLKKVDFLDWKQDQGHRDTQVMRMYHIQNREDYHKYNKICGDIRKLANKLSLLSPTDSFRIKHEQLLLEKLYNIGVLATKSKISDLENKVTVSAICRRRIGVVMCRLKMAETLKDAITFVEQGHVRVGPNVITDPAFLVTRNLEDYLTWVDTSKIKRNLLKYKNKIDDYDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW04</accession>
    <name>G3AW04_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112154</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW04"/>
    <dbReference type="STRING" id="590646.G3AW04"/>
    <dbReference type="eggNOG" id="ENOG502QUJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="261" mass="27742" checksum="B1A2CF209F65759A" modified="2011-11-16" version="1">MTSSDSIHSQGSKELSMSSNEDVGRIHTTGENNQFIIIGHRKYLRSELMEAFGGTLNPGLSPPPTHGFANPSPLGLTSFALTTFVLSMYNARAMGITHTNAVVGLTAFYGGAVQFLAGVWEIMVGNTFGGTAFCSYGAFWLSYMAINIEGFGIAAAYGDDSEQLGNAVGFFLLGWGLFTAMLVLCTMKSTVGLFSLFFTLTLTFLLLAGGEFTGKVGVTRAGGVVGVITAMLGFYNGFAGTANHQNSYFVPHPMPLTRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW06</accession>
    <name>G3AW06_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_100886</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683678.1">
        <property type="nucleotide sequence ID" value="XM_006683615.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AW06"/>
    <dbReference type="GeneID" id="18245417"/>
    <dbReference type="KEGG" id="cten:18245417"/>
    <dbReference type="eggNOG" id="KOG0208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_3_1_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1115"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1144"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1182"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1224"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1257"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1296"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="251"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="488"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="187"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV66420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1349" mass="153396" checksum="5BB0053D996C2FBA" modified="2011-11-16" version="1">MGRRNSKHRKRPSDVAPEPTGDETRSTVRSFSRSQSGSRSRSQSVDRYKARSLSRSSLSRRGSVVSQESVLNEGNNNEIYSGAGSEIIPSSITSFHYPHSFGSRRHQSAASAETSPLLHTREDVESVKSYGTNASNDEAANFKFFKLEEIESAPGGSTYENPEEIVDYNTDWVYPIDKYGAQDIENENPIFEEDDGDDQRSYGSSEFERRRRSSGSSRGSSEELLNDLEDEAEREEFEYKSEYQRYYLAEEDLVIGIAGYQNNILKQTMYYLLCTITLGMAYLVLRWLPRYRINLIGDPCPLGKADWCVVENEYGELSVVDIEKKRLNQRLSSFLNISDDKDDGEVNHQISDPIIGHMHTFKYRYLKFFYNPVEDIFKTNNNWFDQSWTNSNKIADGVPQSLFEERAMIFEENSIEIDDKPILSLLLEEVLHPFYVFQIFSILLWLVDDYFYYASCIFIISMISIVNTLVETQSTMKKLKSISIFNCEVRVWRNEFWKTVLSNELVPGDIFEVDPSLNAMPCDCLLINGEVIVNESMLTGESVPVTKSCLQDEQLELIKDNINVNLPKSYLYNGTKILKRKSHNDEPVKALVVKTGFNTTKGSLIRSMLFPKPIGFKFYQDSFKYIGFMSFIAFTGFIYSTVNFIKLGVPKSLMILRALDIITIVVPPALPATLTIGTTFAINRLKSYQIYCISPTRVNIGGKLDVICFDKTGTLTEDGLDVLGVHLVNNAVGRKEMKFDTLARGIEDIVINRSSVHDSNNGPLLVALMSTCHSLRKIDDDILGDPLDYKMFEFTDSNLKDSEMPIIENYYGHYRILKELEFESNIRRMSVVVETNHSRLVLCKGAPEVMVDICTKQSIPEDFFDLLHKYTNSGYRVIACAYKPIRSKVDMNRESLESNMQFLGFIVFENKLKANSAPTIHHLHDAKIRTIMCTGDNILTAISVGKECGILEKEEAIYVPRFTENPEADELVWENINDPGILLDSTTLNPLSIKDYDYKYKFAITGKFFKYLLTNFKDHESFQQVLLYCDIFARMSPDEKHELVNQLQKIDYTVGFIGDGANDCGALKAANVGVSLSEAEASIAAPFTSRVFEVSCLLDVIREGRASLVTSFSSFKFMSLYSAIQFITVTILYKRGTNLGDFQFLYIDMILILPLAIFMSWSQANKRIIPKRPSANLVSPRILVSLVGNIVILLIFQVILWRMIQREPWYVVPVPGDDENVKSFDNSVLFLFSNLQYIVVSLLLAEGPPYREPLHKNVPYVMTVIASVAVSCGLFLIDSDGSLGNIFQLVNLPTQYYVIIMVMSAINYGVLYVMRRWVYGSIHAAYKRVLGSRHSKKAYKNMQKRVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW64</accession>
    <name>G3AW64_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_96507</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683720.1">
        <property type="nucleotide sequence ID" value="XM_006683657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW64"/>
    <dbReference type="GeneID" id="18250612"/>
    <dbReference type="KEGG" id="cten:18250612"/>
    <dbReference type="eggNOG" id="KOG4525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009601_2_1_1"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="82113" checksum="488BB07C89F4E2A6" modified="2011-11-16" version="1">MAITFNYTDHEIVSSPTVIVSGRTSAPVNGGVVEFINSENRVFPPQYFEVNNGQFKAIVHVSPDTNKFSVRVMDNGTINPFGFPDYRGRSPNVVDSASLTLSYYPLTEDKPVHLCVILGKDSNGAYDMPQYKTARGEVANLDSAIRKLKVAGRLMQAYTQDEMRLSGFSNRSFQFVEETTGHQDIFGYTVQSPAPHQEVKVHVLRSPKTVAQLRDPNLAQQNPKGTNTGGLFSHALDLIHDTPELFSQRQRLNTCIQCAVIYLDAHYDAPNDLILTHAALGGGTGDIKLAIFGSHGLHSWPINFPMVTPCFVDGTHLSKREVANDANQCGTSWECLNITMGAFMHEIGHSLSCPHQIDGVMLRDYIWWNRSFMTREVECLRSKSGGEVIGATGQWPRSCHWNILDKVRFLFHGSFALPIDKNDPSMGHVFSTTLANDDSYGDVNKAPTMYNTPSGDCIVKSDAGVFLVEVITKDLARCHIPYFPRSYGGQGLQKDLLLDYNTLYDQLRSSTKEVNENFSVRVLSLGGDLYIDNFKDHSKNDSKNIIRHDFGLGRGPLTGYKSVLLGNGKDKQEIVIGFDINTVYKIRVYHGGVLDGIRFYYRTGSGSGFTNSPPPIPKRDYVSKLANKMGRLNVAAASATPAPKAPSGQPSSKPAEALLGNVKSHYTDIDLASGETITKLHFRNGAWIDAVQIEFSSGRKTEMLGNNGGGHLSTLEAPGHGYTLVGMYGYVGSWLNGVGIIYTNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW81</accession>
    <name>G3AW81_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CANTEDRAFT_117384</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW81"/>
    <dbReference type="STRING" id="590646.G3AW81"/>
    <dbReference type="GeneID" id="18248568"/>
    <dbReference type="KEGG" id="cten:18248568"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016428_4_1_1"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="24">
        <location>
            <begin position="335"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGV66477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="675" mass="77066" checksum="CC1F70B13EB16FCC" modified="2011-11-16" version="1">MQQMQQFQQSQPQQQFGSYQQLPPHLQQSQPQTQGQNSQQYGGIQGPKQSSIAVDKPNSIHWQHQQQLCQISRSASIPHYYARQYAANSRKVKNPYNDVKSVSLIDATKSIVASVEEQERLSQKSSTPTTNAALLYNKKTVNYYEDDTMHEEERMRQKTNGQQLWCQLDLSGQGISNVSPKLFNYDFLESLYLNNNKLTAVPSMISRLRGLRTLDLSQNKIEDIPGDLGLCYNLRYLYLFDNEIKTLPNGLGNLIELLFLGIEGNPMDPQIANILAEKGTKDLITYLRDLPPTLPKPKARDWILLEDDGEVIDPTANPEAYANEDSNSSSSFTLMSYNTLCQHYATTRMHKYTPAWALDWEYRRPLLEKEVTEMNTDVVCMQEVETRTFHEFWVPRMQKLGYKGLFYSKTRSKTMGELDAKKVDGCAVFYKTSKFELIQKINFEYNSACMGSEKYKKTKDLFNRFMNKDHVALIAFMQHKETGEKICIITTHLHWDPLFNDVKALQVGVLLEELKGILKKFVGANDDVKNTPLIICGDFNSIVDSAVYQLFSTGSVKTHSDLDGYDYGKFTEEGFKNVFKLKSAYETVGELPFTNCTPDFTTTIDYIWYTPGSIEVKGLLGKVDPDYAKHVIGFPDANFPSDHIPLVSKFQIKKNGGHKRADFKPDFRPGSSRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW99</accession>
    <name>G3AW99_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1771-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112208</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684034.1">
        <property type="nucleotide sequence ID" value="XM_006683971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW99"/>
    <dbReference type="STRING" id="590646.G3AW99"/>
    <dbReference type="GeneID" id="18246402"/>
    <dbReference type="KEGG" id="cten:18246402"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069447_1_0_1"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="3">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="250" mass="28483" checksum="23B1734644B92058" modified="2011-11-16" version="1">MQAIDRGAKLVFDDAPTRDYNHATDSNYKSLRAQAEQLYQKRNKLAQQSQAAYKAGNKQKAHQLSEQSKQVLDEAEHYNRQAAEYVFRENNTDSAQDEIDLHGLYVKEAEYFLQLRIVQEVRTNQSHLNVIVGKGLHSKNGIAKLKPAIDDMCDESRLTHRIDPHNSGVLQIDLSKTSINQLPQRWVALTPSTGVYQPSGYQSYAPQYQNQNSHSQGYSQQQQQHNGNQKTNPLVDLFVNILCICINRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX11</accession>
    <name>G3AX11_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SRF-TF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_129032</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX11"/>
    <dbReference type="STRING" id="590646.G3AX11"/>
    <dbReference type="GeneID" id="18249357"/>
    <dbReference type="KEGG" id="cten:18249357"/>
    <dbReference type="eggNOG" id="KOG0015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063931_0_0_1"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="46"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="232" mass="25782" checksum="14F42E6D01384818" modified="2011-11-16" version="1">MSEVTEPKLETPDELPGNNTFSTSTSNQPPDDDDDDEQTGGGKQQKERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKSEGKNLIQACLNAPEEGLGDDQDNQSEGNSPDSPEPAQQQHQPSAQPQQVPTHPLHHQQIQPGVAANQLPPGAHLPPGMPYPQSHPQMPMPPQGYNDPNVYQQYFNMQNGNIPNQQQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX54</accession>
    <name>G3AX54_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112431</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684138.1">
        <property type="nucleotide sequence ID" value="XM_006684075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX54"/>
    <dbReference type="STRING" id="590646.G3AX54"/>
    <dbReference type="GeneID" id="18246516"/>
    <dbReference type="KEGG" id="cten:18246516"/>
    <dbReference type="eggNOG" id="KOG1613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="53"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="295" mass="33308" checksum="AEB4DD57E43FCAF7" modified="2011-11-16" version="1">MESISFKPEILERIIPDVSLERHLKIGIRSNQRLFDEFKNIQILSQKSSHLLTTSYIQNGNTLVICNISYGITELLGGETPEQYSSVYPTLSISRGRSGAPTDEEMNLSQKLYESTLHSRILPSNSLIFKPKVMIDDNLEDLDTNKQFKFNLFVNLKVFDRSGPLFDVCHFALVTSLKAVKLPVIYLNDSFVKLSIDNLLAYPDAELVPLRLNMEVPLVSSNFGLYNLDEKNLIICDLENESEESNIISKVNVVSDGKAFNEFTLINGSLLNITRDEIKSLLRTSKQRAKAINSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX89</accession>
    <name>G3AX89_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF159-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_117936</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684150.1">
        <property type="nucleotide sequence ID" value="XM_006684087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX89"/>
    <dbReference type="GeneID" id="18248610"/>
    <dbReference type="KEGG" id="cten:18248610"/>
    <dbReference type="eggNOG" id="KOG2618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035990_0_0_1"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="333" mass="38333" checksum="CF945EB8A3E19171" modified="2011-11-16" version="1">MCGRYAMTVDVQQLPSQFTRTALRREDPGSSNTDDVKKVTENTYSTTETHFNGSEENVKIFVMNGLEGYRQSYNVAPTKNELIIYKQYSAANNVEYIMETSGFGLVPNWSKPGNTDPLKEVRKQQAMHFNCRRETLLQTSSIWNASKKTRCVVPIQGYYEWMKIKTQKVPYYVFSKDQPLIYLAGFYSHNKNFTDNFNNDQYLSTFTIITGPATKEDSNDLSWLHSRKPIFLKPGTQQWDDWLDPKVPWSHELQIACLDTLTNPAFESITCHKVSRDVGNTSKDGEYLIKELKQEEKRGAIDSFFKKRPNPQISPSPDAKKVKTEPSVKEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXB9</accession>
    <name>G3AXB9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_91504</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXB9"/>
    <dbReference type="STRING" id="590646.G3AXB9"/>
    <dbReference type="eggNOG" id="KOG0424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_12_0_1"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="160" mass="18342" checksum="882864A5BEDEADE6" modified="2011-11-16" version="1">MSLTKIRLQEERKLWRKDHPFGFFAKPVKTADGSLDLTTWKAGIPGRDNTLWAEGTYPVTITFPDEYPSKPPKVKFPAGFYHPNVYPSGTICLSILNEEQDWRPAITLKQIVLGIQELLGNPNPDSPAQEPAWRAFAKDKVTYEKKIKEQAKRYVNYSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXG0</accession>
    <name>G3AXG0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_117132</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXG0"/>
    <dbReference type="STRING" id="590646.G3AXG0"/>
    <dbReference type="eggNOG" id="KOG3235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_2_1"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="212" mass="24395" checksum="D47EAAC6CD18699A" modified="2011-11-16" version="1">MGITIRQADIYDIQAIQNANLHNLPENYLTKYYMYHALSWPQGSFVATTFDEIEEWDDEISLDTVTVKDPKGDTAYIKKGEKIVGYVLAKMEDDPEAEDKTPHGHITSLSVMRTYRRLGLAGKLMRHSLYALCESFGGQYVSLHVRKSNRAALHLYRDTLKFEVTTIEKSYYQDGEDAYAMQKKLILDELKPHLFENAEVVDDFSQDLLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXJ5</accession>
    <name>G3AXJ5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUC189-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_91562</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXJ5"/>
    <dbReference type="STRING" id="590646.G3AXJ5"/>
    <dbReference type="GeneID" id="18250089"/>
    <dbReference type="KEGG" id="cten:18250089"/>
    <dbReference type="eggNOG" id="KOG4547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023936_0_0_1"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="456"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="593"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="656" mass="72585" checksum="EF5334C4696ADB3D" modified="2011-11-16" version="1">MSTVAQVSSSALVASKFDNTGSFLATVVVALDTHQVRVVSVNQSGASLDTSYNLPNDNKVSTLSWIPFQEQEQLLALGLTNGSILLYSPLTNAILTRLSTSSSSLITDFKYSDITKSLWASDITGVIYEWGMDYSLIQKISINESLTIETTETVNSIAIINHNSQPHLLAGSQSIYLVNIKTKEVLRTIPAHIQPIHSIVSVPTDDNLFISCANGDRFINLYSLNKSVPNSVFVTDSPVTDISVGTINDKSILIARTETGNVEVFNSFLSEDVPAVSQSNSRKKKRQQLTNSRSRHADGVISLEQVDLKGSVTPNLPVVSVIIKQNLVLYSWLEDFSVPIFDTLRWLDEKASNSIVDKVNLSKTKQESSVPHHAMNGHDVASAKHYNEGNAIVSDGYNLNHVVEDDEDEEDGEALADKLAKLATDAKTVTPKKTKKQNGINNNTLTTILSQSLKNNDHSLLETVLTNRDQQVIQNTIARLDSSMAIVLLDRISERIARQANRFDQLVYWLKWIIIIHGGVLSSLPGLAAKFSNLHGILSRKADTLPRLLQLQNRMQIINEFNDSKKSQDHPYDGSEDEESDVEYVEELDDANLLNGDFHSGDDYVDSDDMEEDSEEEVDAHGIAAEDFEVDKEDEEGYSDEEIAVDNKDVEDSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXK0</accession>
    <name>G3AXK0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ER to Golgi transport protein Yos1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_101122</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXK0"/>
    <dbReference type="STRING" id="590646.G3AXK0"/>
    <dbReference type="GeneID" id="18245440"/>
    <dbReference type="KEGG" id="cten:18245440"/>
    <dbReference type="eggNOG" id="KOG4779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152125_0_0_1"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="87" mass="9650" checksum="16B132484F46E4FA" modified="2011-11-16" version="1">MFGFGNILYVSLLFLNAIAVLSEDRFLNRIGWGSSNNQASTQFNQFGNNETSVKTRLVNLIGATRTVSRLPLILVNTIVILYLVPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXM1</accession>
    <name>G3AXM1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_102486</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXM1"/>
    <dbReference type="STRING" id="590646.G3AXM1"/>
    <dbReference type="GeneID" id="18245555"/>
    <dbReference type="KEGG" id="cten:18245555"/>
    <dbReference type="eggNOG" id="KOG4406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017277_0_0_1"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="184"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="536" mass="60494" checksum="82EBC8FD75BB9AF9" modified="2011-11-16" version="1">MDRIFYKTSASDRHSKSPVYVFDTSFLPSSNDINYDELILTLMTILPSEKYTLIMFCSGLNKISWIWGVKFLKKFLIEESNLQNLDKVYTVHEGWFIKTLTGLLANYQLTRKNLTLTRKLLENFNLNNDEFKLVGSGSGGLIVNCASLFDLDQLVDIDNIKISLNVYKHDYQLDGFRSLNTAATPLAWQVPSESLKYHLYQTYNIIDTYGARVELIFQRPGNKLSSEIFVDCIKRDQIIWINDWNLYCIATSFKKIVAKLPPLLPIELITLPIKDSTLEQNFADILNHLSYDFRVVLVSIFKLLHKLVNNQHITRLTSKSLAKIFVTTLSHQSYSKANESNLIVVNSFIKKVIENFGQFGKSLTAVEMSDIFSECREENSYIDYDMTVDSDGDTDEPISEAGGDVNLSPKKVLGSNEHVLNTMTSFASISTIGSTFSKDVFLSPTKTQSPIKSSLGSPVKAAADIDASISVQYPPQRYRFNTPAHSKEVNVVSQFIQSQVSSASPKKRPVIRGVKVGELAKLYEERAQGLELLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXN1</accession>
    <name>G3AXN1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_102321</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXN1"/>
    <dbReference type="GeneID" id="18245543"/>
    <dbReference type="KEGG" id="cten:18245543"/>
    <dbReference type="eggNOG" id="KOG1278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010714_4_0_1"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007361658" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="23"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="632" mass="72280" checksum="07E7A0BDCD27A3BF" modified="2011-11-16" version="1">MIPKLNLWSILAVVQLMAVVSGFYLPGVAPTDYKKGESIPLLVNHLTPSMHHMSQDSKTYVYSYDYYYPKFHFCPPANGPQKQSESLGSIIFGDRIFNSPFEIKMLEDKQCQRLCRSTYSKEDSLFVNRNIRAGYSHNWIIDGLPAAHLVQESRTKTNYYGLGFSIGEVDQSSFAHFYNHFSIQLEYHKRDEHTYRVVGFTVSPSSLDRRNVDGASDADTYCSLDLPPITLKKGEETQLDFTYDVKFVASDKAWATRWDKYLHVYDPKIQWFSLVNFSLIVVVLGIAMANILLRTLKNDIMKYNEVNLDNEISDESGWKLVHGDVFRPPRYKLIFSVLVGSGIQIFLMTLVTIVFALFGVLSPSNRGSLSTFMFILYIFFSAVSSFVSSYLYRFFGGEEWKMNILLNPLLVPGSLFSLFVLLNFFLVFVNSSGAIPIGTMLAIVVIWFVISIPLAVVGSLLSYKRPMVTIPVKTNQIPRQIPPQPWYLKQIPIMLISGIFPFGSIAVEMYFIYTSIWFNRIFYMFGFLFFCFVLMIMTTSLISVLMIYYLLCSENYQWHWKSMFIGGGCAVYVLLHSLFLVTGQNLGNFTSIVLYFGYSLVISLLVFLCCGAVGFVSCFVFIRRIYSQIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXQ4</accession>
    <name>G3AXQ4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2 11">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_112542</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 11"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXQ4"/>
    <dbReference type="STRING" id="590646.G3AXQ4"/>
    <dbReference type="GeneID" id="18246570"/>
    <dbReference type="KEGG" id="cten:18246570"/>
    <dbReference type="eggNOG" id="KOG2915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_4_0_1"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.20:FF:000002">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="14">
        <location>
            <begin position="64"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="358" mass="40344" checksum="560E41DE3A2A7CAD" modified="2011-11-16" version="1">MSFFSYKDVIEEGDLVLAFISRTDTKPITVTKGQILNTRFGHFKHEDMVGLKYGEQMEGAKGYGFIHLLHPTPELWTLSLPHRTQIVYTHDSAYIMQRLNVISGTRVIEAGTGSASFTHSFARTVGAAGRVFTYEFHEPRYIEAKKELEEHGLTTNTLITHRDVCEGGFEIANIPANFVSKNGGIDADMVFLDLPSPWTAITQLDSVMSKTSKVGVCCFSPCIEQVQKTVEALQEHGWINIELVEVSGRRWEARKDMIRDMGDVVKRLKDIQSRRGKGIETRKRGYLANGKRQLEEETDDSDSGVNKLPNTGKGFNPFGRGERVKEGDANYTWRNVTKVESEIKTHTSYLTFAIRLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXV6</accession>
    <name>G3AXV6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_133113</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXV6"/>
    <dbReference type="STRING" id="590646.G3AXV6"/>
    <dbReference type="GeneID" id="18249671"/>
    <dbReference type="KEGG" id="cten:18249671"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002888_1_1_1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="653"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="708" mass="78833" checksum="78FCD0EE1338A4A2" modified="2011-11-16" version="1">MSTSMSSTIVEEKLNPSIVKKIHREVRFGNYILGSTLGEGEFGKVKLGWRKDGKLPNQVAIKLIKRETLSKDTESEIKTHREINSLKLLSHPNIVNLVEVMKSGKYIGIVLEYASGGELFDYILNHKYLKEPLAKKFFAQLVSGVDYMHSKGLIHRDLKLENLLLDKNKNIIISDFGFVNSYNLSSNNDLMKTSCGSPCYAAPELVLTPNPYNGKKVDIWSLGVILYAMLAGYLPFDDDPSNEDGSDIIRLYHYICKTPLTFPEYITPLPRDLLRKIIVADPKKRININEIRNHTWLSSYANLLSIRQPEWDKIYKDKQTKSISSTTSSVNPSVSRSQNASKRFSMINEPTNSAQLTYNAFKKQHGRSTSSGSASNIFMSSNTSIDEHNEENIQVGTVAAPGGNKISTIIESPKRHPLSVINDTTFSINPNTTIPIPIAISNSEKPVDAGAKAIHSSTSRLPHQPKKPRPTSYHPSSSYSAYNSSNPSALDFRYPSPINIPISQFLPPSSGSTPKNSPPKGSPPKSDIESLSLSSRRNSVVTAINVNGVLTRDNSEKRNSVLIYLEDRMNNIDLAEREREPETTVSTSPIMKVTTHVSVAEEPASTAAVPSVEKIVEPTPRIRERSDKVDKETKRRNRFSLLSIYSNYSTSQVDTTLVQADSSRRKPDVDKPKASVSNSSSSLVKRNKEVSAAKKVMDFFKRRSIRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXV7</accession>
    <name>G3AXV7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112567</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684717.1">
        <property type="nucleotide sequence ID" value="XM_006684654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXV7"/>
    <dbReference type="STRING" id="590646.G3AXV7"/>
    <dbReference type="GeneID" id="18246586"/>
    <dbReference type="KEGG" id="cten:18246586"/>
    <dbReference type="eggNOG" id="KOG3164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053567_1_0_1"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="258" mass="29210" checksum="4D903C5A0D37C0DB" modified="2011-11-16" version="1">MRQKRAKSYKKQMNVYVHAFKFREPFQVIVDDEIVTTSDKASFNLPRGLSRTIQGEVKPMITQCCMQALYKTNNQSAIDLAKTFERRRCNHPPSDPLTPVECIKSITLPDNKFKYVIATQHVELRNRMRTVPGVPFVFMKNSVMVMDSISSASLRYAEKLESSKLTGGLNDVKVGTKRDLEEEEDGEENKSVKPVVKKKKGPKGPNPLSVKKKKSKEDEKVSEKVTKTRRKRKHTRKEEKSGDGEENSSDDGGAGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYF0</accession>
    <name>G3AYF0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_101992</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYF0"/>
    <dbReference type="STRING" id="590646.G3AYF0"/>
    <dbReference type="GeneID" id="18245521"/>
    <dbReference type="KEGG" id="cten:18245521"/>
    <dbReference type="eggNOG" id="KOG2303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="714" mass="80643" checksum="96DF7F59884ECA60" modified="2011-11-16" version="1">MGHYITVSTCNLNQWALDFEGNRDRIIESIKEAKDHGSSLRVGPELEITGYGCLDHFLENDLYDHSWEIYSEILANTDTHGILVDIGMPIIHKSVKYNCRVISYNGKILLIRPKLVLANDGNYREMRYFTPWSRPKYYEEYRLPIAIQKVTGQSTVYIGDCVIETAETRIGAETCEELFTPQAPHIAMALDGVEIFTNSSGSHHELRKLDTRLELIMEATKKCGGVYLYSNQKGCDGDRLYYDGCASIIVNGQMIAQGSQFSLKDVEVITATIDLDDIKSFRNQKSTGIQAVAERNPFKSIEAGIELSPQSNVFNPLIRPSLPISVKYHLPEEEIALGPACWLWDYLRRSKCAGFFLPLSGGVDSCATATIVHSMCRLIVSSCEDGDKQVISDIQMLTKSPDWIPRTPQEVAGKLFYTSYMGTKNSSAETRSRAKELADKIGSFHVDLNMDSLVTAVVSVFEVATGRKPIFKIFGGSQTENLALQNIQARLRMVLSYLFAQLLPWTRDIAGGLLVLGSANVDECLRGYLTKYDCSSADLNPIGGISKTDLKRFIGWACTNFELPILREFIEATPTAELEPITADYVQSDEIDMGMSYAELYRFGRLRKVDKCGPLAMFVKLYHEWSQPPYNLTAEQVAEKVKRFWFFYAINRHKMTTMTPAYHAEQYSPDDNRFDLRPFLINPRFPLANKNIDRLVEAITIREDEIRKVNLSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYR0</accession>
    <name>G3AYR0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase spindle elongation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_118801</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYR0"/>
    <dbReference type="STRING" id="590646.G3AYR0"/>
    <dbReference type="GeneID" id="18248660"/>
    <dbReference type="KEGG" id="cten:18248660"/>
    <dbReference type="eggNOG" id="KOG4302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320776_0_0_1"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="105961" checksum="B4675BB8BB0600D2" modified="2011-11-16" version="1">MDVTFTNNDNSNHKHLDIIAKKVNKTIEELNDVYSEIGYTTTEISIKKSEIFSIIEDTIHNCTNSLKREKASIENECEWLRQQIKIILAMMDDAKGTKCLSKLNKGIVFNDTDLFEEGFKEEITKKLTNLKSKRENFYEDSPFNITNNSSNIMEEISFEKKYEGMLESSPKLSLMKLKRELNAVFLDVLKHFMKTFKKFNSCNLMYLDLIETIGNIDSQEINYDYLKTLPAREDAENHKELIESFESTIRHLKLSDMKTASFSSFVDNSHEDMAFVISSPRKLKGKDIEADGEGYDRVKEVGGSTAEFVFHLREINYKIVKSIRTLKMTKISAELITDLNKQINYCEVNVEERKTKMTVIISKILDLVEELEYSEDQLINLQKQFNEREKEKSDESINETFIDIETLNFIQSNPVQFGLNDSHLAFIANFLELLSKVKETKQKKYEYYLGHCSRLWEKLGEEEHYIEDFVLQNRGLSDKSMYNFKTELNRLLSKRSQYIDNFIFDTRSEIEEYWRKLYYTETEMRVFKYFDYELDPNDSYDKESILKDHENELSQLKREFESKSEILQDYEELKQLILDQDFLIESSKDSSRLLSKNSCKILLNEERIRKRVLKSMPRLIENLKKSLTIYNKNQVLKGRNPFTITGEDFYKRVLAIENEKLTKRKNNSHNKKSIEIHHSNNSHSGSNSVSPYKSQRISQMQPKRVSPSRPLSVSTSRHSPITSMNPIRKPAIKLTRNNGHPSTSRTNRIINAMSTSINGTNPGVSGFPSNQISHISNSSQSSNQVSPYGIDKHVNTSNTLLKSFRTSLQPLNSPLTADSKSGIKNSPSFSTMSPLRVNFSSIEENNKENTDVTVKRKKEDLTLNITPMKSGRLVKWDKNTSTPASESRSLGDNSSNLGEDYLQWRLEKLSQLNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYS2</accession>
    <name>G3AYS2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Anp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_129353</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYS2"/>
    <dbReference type="STRING" id="590646.G3AYS2"/>
    <dbReference type="eggNOG" id="ENOG502QRPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017872_4_0_1"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42845" checksum="06385F54E80117D8" modified="2011-11-16" version="1">MGILHHPIARNIRRKPLTVVAPLAVIFMLYLFLFSHRDSSKSNSRRTASKYSYKQKNKSWFNKNKDSVILRNLPKNHLSHYDLNQLTVSSTPLENKEEVLILTPMSKFLPEYWDNLNRLTYDHSLISLGFILPRTEDGNVALRKLEIAIKATQGNPVTKFKKITVLRQDSNSLESQLEKDRHAFSVQKPRRALMALARNSLVFTTISPSTSWVLWLDSDIIETPHSVIQEMAAHDKPVLSANVYQRFYNEESKKNDIRPYDFNNWVESEEGLKLASTLGEDEIVVEGYAEMATYRPLMAHFYDHNGDKNTEMALDGVGGGAVLVKADVHRDGAMFPSFPFYHLIETEGFARMAKRLGYEVFGLPNYLVYHYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYZ1</accession>
    <name>G3AYZ1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_101593</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYZ1"/>
    <dbReference type="GeneID" id="18245484"/>
    <dbReference type="KEGG" id="cten:18245484"/>
    <dbReference type="eggNOG" id="ENOG502S625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933823_0_0_1"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="283" mass="31251" checksum="694F13BCE0A60DE2" modified="2011-11-16" version="1">MPSLDLPSLSSTGETYTTPSVTVPPNDNNPYILTTSNVNGTVFIAVGSIVGAMLLAFILYHLIRSITASRNAKKALLDDKQTYEKYQNNNSTAYGLSPSTTLNFFGDTRNSQVGKLPLLSHHATKSFSDMNGGYIDSQLGDTSTLYQSEVGMPTVKNDVTKMFISPTAEVMSHNRVKSQIFGSNTNLFNNSMSNMSNTPDQTQHSTIPNLYISNDNTNSEYSLSTNTNSHTNNHYPIQRDMSKQDIPEHLQRMAANSSSQNTLNVKPNRKTIPSMYLEDLIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ11</accession>
    <name>G3AZ11_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_97047</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ11"/>
    <dbReference type="STRING" id="590646.G3AZ11"/>
    <dbReference type="eggNOG" id="KOG0811">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059257_4_0_1"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="208"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="302" mass="34599" checksum="4EBE17DBC0072ABA" modified="2011-11-16" version="1">MSFNNFSEDLEAGGADAHSLHYKDFPEFETSSQQIESLLFNINNNQLTSLKNLNSQYDTLLREPPDSTKPLKLNKLSYTITALTEKITKNYKIVNELTQKINSYLNECENNHDDEDTLVYLRQKESLVIKQIKSSLKNYQTHQKKYESLQQKTIDKYGKVTDSVPSEELDSGVYSSGTNDHIGNGTVSGGQVSIEYEPVNAEELEQQTLLIQEREREIEQIGQDITYINEIYGNLEDIVHEQQFTIDTIEDNILKYSDDVQGASVELRRAERYQRRSSGRMLCCLFILLGILGFIILIGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZD9</accession>
    <name>G3AZD9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_97131</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZD9"/>
    <dbReference type="STRING" id="590646.G3AZD9"/>
    <dbReference type="GeneID" id="18250659"/>
    <dbReference type="KEGG" id="cten:18250659"/>
    <dbReference type="eggNOG" id="KOG0171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_4_3_1"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06462">
        <property type="entry name" value="Peptidase_S24_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000018">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="186" mass="20969" checksum="3D7C600C25B6F29D" modified="2011-11-16" version="1">MQKVRFVATTLSWTLRAGCVAHFLHEYVYEFTETRGESMLPTLQAQHDYVHALKGYRYGRNLDIGDCIVATKPSEPTQRVCKRITGMPGDIVLVDPSSSSPLTNTPNEVILHDGFNKYIKVPDGHVWVTGDNLCHSLDSRSYSSLPMALIKGKIVAANSMDKGFIDAAGRLRFWNFRWITNTFEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZF0</accession>
    <name>G3AZF0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112940</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684880.1">
        <property type="nucleotide sequence ID" value="XM_006684817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZF0"/>
    <dbReference type="STRING" id="590646.G3AZF0"/>
    <dbReference type="GeneID" id="18246746"/>
    <dbReference type="KEGG" id="cten:18246746"/>
    <dbReference type="eggNOG" id="KOG3834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_657398_0_0_1"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="179"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="395" mass="43463" checksum="474D417FC9B36548" modified="2011-11-16" version="1">MFSFAKKLVDRFEGHEGPQDSYFKNLLDINNRGYALRVLAVTPQSPANVAGLEAWFDYITGINGHTLPMAFPSLGDHSYSINNDGTINYGGSTTAEHAGAVNFDLIHQELVNVCRNPNTNKEVVLDVWSAKGGVLRQVRVPLSQENLQESTENTRKLIPDPFQAIGLTLQSQHINTATYVWRILATHVNSPAFQAQLVPYSDYIIGCDSAFPDDAYGKGLLAQGGEALLSQTVSRYYNFNSERSHEDFVPITLYVYNHDYDVLRPVTVNLTRTWGDGSNKGLLGCDVGYGLLHRIPEVVGKFDSEKLTDDVLYESKDVEFQLPPPGSDTFTPAADAFTLAAPLAPPKPGKKKKHTRPVADLNEYMNEELQKSKEADTSTVKPVEGSVAPPPKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZK8</accession>
    <name>G3AZK8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112481</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZK8"/>
    <dbReference type="STRING" id="590646.G3AZK8"/>
    <dbReference type="GeneID" id="18246537"/>
    <dbReference type="KEGG" id="cten:18246537"/>
    <dbReference type="eggNOG" id="KOG3997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_1_0_1"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="55"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="379" mass="42406" checksum="3D6FC4708A925531" modified="2011-11-16" version="1">MANLLPATTKTMKKASTKATSKGSKTFKYPRVADCAFKFGAHVSTSGGVSNAVTNAMDVGAYSFAMFLKSPRKWVSPEIKDEEAANFKQLCEKHGYDPRTDILPHGSYFINLANPDAEKEQKAFDSFVDDLKRCEKLNIGLYNFHPGSSLDSDHKEALARLAKNINKAIEQTDFVKIVIENMAGHGNLIGSDLQDIRDVIDMVENKERVGVCVDTCHTFAAGYDIRTEKDYHTFWNKFETVIGWKYLSAIHLNDSKAPLGANRDLHQKLGYGFLGLEVFRIIANDEKLKKIPIILETPVGNDDSIYGEEIKLLEWLQDRSIDDVDFIKKSSELSSSGAKERAEHLKKFEDKAKKTAKKPATKRKSGSIDSMLSKKPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B082</accession>
    <name>G3B082_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113059</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685196.1">
        <property type="nucleotide sequence ID" value="XM_006685133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B082"/>
    <dbReference type="STRING" id="590646.G3B082"/>
    <dbReference type="GeneID" id="18246807"/>
    <dbReference type="KEGG" id="cten:18246807"/>
    <dbReference type="eggNOG" id="KOG0832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_4_3_1"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000055">
        <property type="entry name" value="Mitochondrial ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48693" checksum="151B5D47F34776E3" modified="2011-11-16" version="1">MAIAVRPYSASTGTSSESGAETTELSQRQLRERALAEALARDEEAQAKAKLLVDMKYQSKDLIARLNKTPAHLIKDRVSKLQSDLTSIDAEKVEMLDKQLEEFMLENLKLPAEEITNRPWADLSTDRKFIDPSNNKSDSGTNTFKSTASNSILNQYPYLKPTPDHHEYSTQELYLRYLNHSRHSGNLGSKLTDVYQPKNEVNRPKSISDMTISTLMAAGCHLGHSKAMWRPSTQPFIYGEYDGIHLIDLNHTLVALKRAVKVVKGVANKGGMILYVGTTKNWEQQRALEAAATRSNGYYISRKWIPGTITNFTQVTKHQGESRLVIDMMDQPSTGSLDGSSPDDLIKPDLIVIMNPVENRNCINECIKSRIPTIGLCDTNMEPSLLTYPIPSNDDSMRVSSMMLGVLSRAAQEGIQERRESVHQYRSQKNSAQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B096</accession>
    <name>G3B096_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_129620</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B096"/>
    <dbReference type="STRING" id="590646.G3B096"/>
    <dbReference type="GeneID" id="18249394"/>
    <dbReference type="KEGG" id="cten:18249394"/>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031312_1_0_1"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="363" mass="41448" checksum="EBBC6C0CE4AA3AB7" modified="2011-11-16" version="1">MLSPNQKKDKVIRSTDLDALACRLSCAQQGYFLPMDNNISKLVASYSKYLQFCEGYTNLSASRTFRMAFNDRKFPIINRGTYLRTQSISQIVEEFIKEFGTCQILSLGGGSDTRCFKYVSPNVKYLEIDFPETAKIKKLTILGDNGLRAIVKYEGEEHIGLDVTTRDQFNDIEPDLHTSNYHIIGYDLRKLTHSSEVLQFVDSSLPTLVLSECVLCYASPQENENIINIWSNYFGSTLMSLIVYDPISLKDAFGAQMADNLQRRGINLLTFNAFATVESKLEFFHQLGLKNSKVTDISSVGGYESTGAWFDEEEVKRISKLEIIDEVEEIKLLFSHYCLLYGENQSSRSFRAINNWRWKLESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0E2</accession>
    <name>G3B0E2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_92599</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685064.1">
        <property type="nucleotide sequence ID" value="XM_006685001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0E2"/>
    <dbReference type="GeneID" id="18250211"/>
    <dbReference type="KEGG" id="cten:18250211"/>
    <dbReference type="eggNOG" id="KOG0770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_2_1"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="139"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="244"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="345" mass="38022" checksum="D14BE47BD7FA1F40" modified="2011-11-16" version="1">MSTLLTTPTVPLGYPPQHYDTNFGSECIDMLAKDDNDNNKASESPIINCMIAGGLGGMVGDTSMHSLDTVKTRQQGFMQNLKYKNMIPAFTTILKEEGFFRGLYGGYSPAILGSLPSTAAFFGMYEYSKRTLIKDLRMNETLAYFLAGILGDLASSVFYVPSEVLKTRLQLQGRYNNPYTKGSGYNYKGLVDAVKTIHRVEGSRTFVFGYKETLFRDLPFSALQFAFYERFRQLAIFYNDSEDLSIGAELLSGASAGGLAGVLTTPLDVIKTRIQTATEASTSAVQMSTIKALRSIYHTEGVLGMFYGVGPRFIWTGIQSSIMLLLYQVSLKKIDSMLVSKGALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0F8</accession>
    <name>G3B0F8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Regulatory protein MIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_92615</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in glucose repression of glucose metabolism genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0F8"/>
    <dbReference type="STRING" id="590646.G3B0F8"/>
    <dbReference type="GeneID" id="18250212"/>
    <dbReference type="KEGG" id="cten:18250212"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027078_0_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV65392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="450" mass="48407" checksum="EBBD15615519E949" modified="2011-11-16" version="1">MTEVVNDIDANSPKVAKTKDDRPYKCPMCEKAFHRLEHQTRHIRTHTGEKPHPCTFAGCTKRFSRSDELTRHLRIHNNPVTRKRKNKMNHDYTSQDLDEHRHSVSDSGLAKLAEAAAIPVQLQSLPSGAQFIPVAIDKGGQAIYHQGYPIYLVTAGQGEQKPYQLQNGSAVFSMPSSPTTGSATGTSGSTTAPSGPHPSPQAATLTPSIIKSESSSSIGVFSNESSSHSLSTSPDQTLYTPIPGSAKKLPSLTNLNEYFVLKAGSNKTSSSSLSSMQFGASHASHPNLPSLGSLPRMTPIKSIPVPNPQRNISYPSTPYSLGASATYFAPSQGLKVRDKSSSSLNLEFAHAQKKSRPSSPSSSFTNLVMTSNSSYHNPGFIISPSETPLQTPSQSPHLKPANAQLQPDLVKLNSKLTEGEVVVKQQDNTNSIANSGTQLPPIRSVFSFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0T8</accession>
    <name>G3B0T8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED16</name>
        <name evidence="12" type="ORF">CANTEDRAFT_120811</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0T8"/>
    <dbReference type="STRING" id="590646.G3B0T8"/>
    <dbReference type="eggNOG" id="ENOG502QWAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013428_0_0_1"/>
    <dbReference type="OrthoDB" id="4139168at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021665">
        <property type="entry name" value="Mediator_Med16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11635">
        <property type="entry name" value="Med16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med16 N-terminal" evidence="10">
        <location>
            <begin position="154"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="11">
        <location>
            <begin position="856"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="955" mass="108015" checksum="61424DFEDD357BB5" modified="2011-11-16" version="1">METIRVDSKSLNHEMKCYDTISWSKNGFIAYSIPSSNSKDNLLLTYLENVDGKKWQLAKPQKLCVKPTLDGFHSPELSLVSWSNLSTDLAVADVYGNFYILLAGVGLVREDSKTTPPGDSGSPSYELTTYNHLEMIYRDIITNQSNQRPNVAVQFVAFAWLPIEKNQIINTEAKLLNSANSSGMSFSYGYGVEQYRPMNLCHPISTKQACIALRTNGELVLHYQGEHKVEYHKLLVNLNEGYSYNLHIEKVAFGFPNEKKIIVVTYDSLSNKIRTYSVTINWGFLVEAASKQKIDPHFNTPKDLQKSPTLSCCLINEMSPNFKSETEESKPSEYKPKQKIGKLAFIEIISPVYDEKDTIDILIGYEFYDENLKVSTTFNRYKILESSRLISDTFGEIGRKKGAVSDGSNIQKEFNLVYQDKLVLPKRVLKSTNQTSDFLVLCEDGSIESIVKKESKATAWSKNGNSSIPESIRSVMDTGFSMGNLHISGKNPLIIAFSPNGIGAIYTEINEPTTNLKLEFVEKTSSTGISAEELYITAVGFAFQHAFACYCSICSDDILILIQLEVERISRLIKKMIPGSQKQLEATDRFIESILCESHKAINFQLDIFNKESVDKLLSNPPLQKLLSLQLILGGLDYRVNDISENIAWIILNLRSTSFGIMFSLSSIYRQISKKKPTEDTMEDSITRAESIISLIGNVRWLVELIICLNEELLQIYISRKHPESSVIDLNNSIVLPVLLSKVPRLFLMYALSSIGKTHEVLKKLNKDLSDSNKLFTPMKDALNRYFTACANSPLNLNLYESFLRECDTYITTETLNLTKTRPKGHILKMEQQLVCDGKVHEDMVKMGQWIVAKFASNIPRDLKVAEMFYYNVDWLDISYKTSIPRHTYTKHGRIDALRKVLIDAKDTSVILRKCTRCRSISLVNDPLVFSNGTLGLWTMVFQRTCICGSAWVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0X5</accession>
    <name>G3B0X5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_120859</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685638.1">
        <property type="nucleotide sequence ID" value="XM_006685575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0X5"/>
    <dbReference type="STRING" id="590646.G3B0X5"/>
    <dbReference type="GeneID" id="18248809"/>
    <dbReference type="KEGG" id="cten:18248809"/>
    <dbReference type="eggNOG" id="KOG0289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023894_0_1_1"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="15">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="475" mass="52748" checksum="11F708388E2C9507" modified="2011-11-16" version="1">MFCALSGEVAKEPVLSPRSGKIFDRKLITTYVSTNNKDPITDEPLGVEELIAINVEDRTVVPPKPPSFNSIPSLLTTFQNEFDSMALEIFSLRKSLHKARQELSSALYNYDAAVKVAANAIKERDDVKTALQELTLSIGNDAMGEEDHENGSNGLDVAVPVQEIEAARQELFQQHKTQKVSLPAADDVSIIFEGDVSIKKYNAFFFDERVQKLLVSSGKETTTLDLVTKTNTVATQKGVVQHVSYIEFEGLVVPVFASKKQIKFEGITIKFRDEIVDIQPHPKLKNIYAVVCTKSWSLNVGDKKCLFVQLDNEYTATTGSFHVDGALMAIGTTSGTVLVYGVADGSVASTLEIKYPTVDKVQFGLNGYWLFVSSSDKSAHSLQVFDLRNHSVVHTIDFEELNDFAIDQSCSLLLTCNSKEISFHKYTKKGKTWNDFFKSVEVESTRNLVITKFENGVIHGVQLGDSIKNFKIEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B139</accession>
    <name>G3B139_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_120978</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B139"/>
    <dbReference type="STRING" id="590646.G3B139"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055194_0_2_1"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="9">
        <location>
            <begin position="54"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="10">
        <location>
            <begin position="221"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29979" checksum="78BA3B129E2F7938" modified="2011-11-16" version="1">MSRPEEIAPAEIFYNDDESFKYTSNSRVQMIQAKMTLRALDLLNLESEEPHLILDLGCGSGLSGEILTEEGYNWIGMDIAPSMLATAIDRGIEGDLFLSDLGNGVPFRAGTFDAAISISAIQWLCNADSSGSDPKKRLMTFFNTLYASLKRGGKFVAQFYPKTDDQTESILGAAKVAGFGGGLIIDEPESKRNKKYYLVLTAGVSDRGVNLEGAEMDAPEMKRKLNKKMMRKMESGKDFINRKKEIMRKRGRKVALDSKFTGRKRRSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1C2</accession>
    <name>G3B1C2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_113682</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1C2"/>
    <dbReference type="STRING" id="590646.G3B1C2"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_1_0_1"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="14"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="401" mass="46020" checksum="C638244A6DF13C8A" modified="2011-11-16" version="1">MAQSNHSNLVGVHYKVGKKIGEGSFGIIFEGINLLTNQQVAIKFEPRKCEAPQLRDEYRSYRILSDAEGVPKAYFFGQEGVHNILIIDLLGPSLEDLFDWCGRKLSIKTVIQIARQMIQRVQVIHEHNLIYRDIKPDNFLIGKPGTPQANQIFLVDFGMAKQYRDPKTKTHIPYREKKALSGTARYMSINTHLGREQSRRDDLESLGHVFMYFLRGSLPWQGLKAPTNKQKYEKIGYKKQVTSINELCFGFPIQFAQYLNYVRGLKFDEDPDYNYLVSLMDKAMVSINAEDDERYDWMDLNGGKGWDAALNKKANLHGYGNPHPPRPQQQSSSSKLNKGKKANYNSINPDKNRHFLNASYNSGGDHYQSGMVPIRDHGSLHSENTSFNEGRSWWSRLRCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1F7</accession>
    <name>G3B1F7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_93195</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B1F7"/>
    <dbReference type="eggNOG" id="KOG4204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001360_2_1_1"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="636"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="929"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1368"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="943"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1368"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1395"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1408"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1455" mass="165578" checksum="36837FFB774E86C2" modified="2011-11-16" version="1">MSNPDPWGNQNRPLGQNFNRQHPPVLPPPATLETGGQKFYPLPSLPSLGNGQHNQSGHSFSIPALGSSDQHPDHRQHSTSLPPAMALAEQGQHHSPPHHQQQLAGQHQPQPHGPSQTPSAVSSAGTVPTIQSTQASTGSTQPPQQPSSQAQPPQPQPAQQPPSPGQSVQQQISQNVPNRSTTTNVYRPLNVKDALSYLDQVKIQFYNQADVYNNFLDIMKDFKSQSIDTPGVIDRVSTLFRGHPNLIQGFNTFLPPGYRIECSMDPSDPNPIRVTTPTGTTTTTKTDWHSDELAASDLVTQQGQQPGQQPDGNSDQMNHAITYVNKIKTRFANQPDIYKQFLEILQTYQREQKPIAEVYEQVTVLFSNSPDLLDDFKQFLPDTSAPQPAAYNSMSQLPPVGNFQPPTGNGPSPSNGQFGHHVPYPPQQQYPPASQFNQHLIQQQQPSQLQQQKFPATSSLVEASGVGILNGGMNNDMLTRKKKSISEGYGYDKNYNTEAQYSSMRTDIQPKIDSNTQISSKNGITTVTNPTLVPGVPEPIPSSNINRTSSLSEEINFFDKVKKAIGNKQTYNDFLKIINLYSQDIIDKETLIDRVESFIGDLNPELVDWFKMFVGFKEPEHIETIMFKKHQLELSFCKAYGPSYRQLPKAETYMPCSGRDEMCWEVLNDEWVGHPTWASEDSGFIAHRKNQYEEILFRIEEERLEYDYHMEANLRTIQTLETIANRIANMTPEQKANFKLPPGLGHTSVTIYKKVIRKIYDKDRGFEVIDALHENPAIAVPIVLKRLKQKDEEWRRAQREWNKVWREMEQKVFYKSLDHLGLTFKQADKKLLTTKQLISEISTVKVEQQNKRLYPLTPKPQEQLNYKFNDLEILYDILRLSDIFINKSSNYSSNDREKLVQFFQFFVSLFFSIPHEEIEAKLNERNSKEINSNATSKEEEPSDVTNETSDEISSPSKKRPRENDLLKDVLKKQSKSKKDEPEASPQNSESEDQLDEIEKASDLWISTTGRKFSLKDNEASLEKRDVYNLFSNTTIYVFFRHLTTLYQRLEEIKLMNEVIAKDVKSRTTPQFAKDLNLIGHQLEDMNVEITGDKNCYKQVLSLTERLLEGELEHQWFEESIRQAYKNRAYKIYTIDKVVQAMVKHIHTMTSDSKTSEMMVLFEADRKSPISTTKDQILYRMQVRSHMTNDENMFKIAYRETDSTVNIQFVGLDDLTINDHKSAEEHYNYYVTSYVMSHPTEGVPASKIHMPFSKDFIENIDEDQCNGYSDSQLKVSICQNSYRLFFEADTHDEFTTNSVYEKPTEDSKTREDKLSTLKKLLEDEELGWKSTLSQSQAAQADVYEEKIRNLFDAGIEEYKSIKIEIEEPEKATEDVEMRDAADDNNGTVGSKQKKNSKSESAKHPDMTIDDSTMVQANDTTIQQDGNDTTADDNTVNESIVGIVATAPSTAENHEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1U9</accession>
    <name>G3B1U9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_120120</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1U9"/>
    <dbReference type="STRING" id="590646.G3B1U9"/>
    <dbReference type="eggNOG" id="KOG0610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_84_1_1"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097035">
        <property type="term" value="P:regulation of membrane lipid distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000749">
        <property type="term" value="P:response to pheromone triggering conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001236">
        <property type="entry name" value="AGC/RSK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="162"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="554" mass="62716" checksum="F9E0D4B542FEE8B6" modified="2011-11-16" version="1">MIKIFNKNRRLDSFINGDVTVSLRHNDSVLSVDDPDHVKLPGKVYGLEGKDEVVTDSEGHLMPPQPPYGSPKPHQQPPAGTGGESPFQRTLRRVASAPLVNLLKTDSSASNVSTKTAEPEFDLSKHIGEITIKSRTRSSTQGRMYSKSSTKVTDVQVRPDSFEKIKLLGKGDVGKVFLVKEKCSNKLYAMKVLNKKEMIERNKIKRVLTEQEILSSSNHPFIITLYHSFQSEDYLYLCMEYCMGGEFFRALQTRENRCINESDARFYVSEVVAALEYLHLNGFIYRDLKPENILLHQSGHIMLSDFDLSKQTDLIQNPVMNDLKLDTKSCIEGFRTNSFVGTEEYIAPEVIRGKGHTSLVDWWTLGILLYEMLYGTTPFKGKDRKRTFSNILKKDVKFFDTKRTGNGSVSSSTKSLIKKLLIKDENKRLGSKNGATDIKTHAFFKNVSWALLRNSQPPMIPVLNKAGTVTPKKIEKEFETHDHQESGISTTTSTSNSKVETDDPFRSFSSISLFYNEAYEEDDVTNNGQYYVDNSIYSSVYYTMTKSPKKGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B224</accession>
    <name>G3B224_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113353</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B224"/>
    <dbReference type="HOGENOM" id="CLU_2978917_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="58" mass="6730" checksum="DD72960A969F7F5E" modified="2011-11-16" version="1">MSIRTRLQKFTKRFSRREKIQRKQNKERINPGVSAYGRSPKPFERPGLGGVGQRMGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B258</accession>
    <name>G3B258_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="6">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_113380</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573</strain>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides. Required for the formation of the di-unsaturated sphingoid base (E,E)-sphinga-4,8-dienine during glucosylceramide (GluCer) biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46280"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:85953"/>
            <dbReference type="EC" id="1.14.19.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="6"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B258"/>
    <dbReference type="STRING" id="590646.G3B258"/>
    <dbReference type="GeneID" id="18246928"/>
    <dbReference type="KEGG" id="cten:18246928"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV65054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="571" mass="66511" checksum="4EDDF849564167C8" modified="2011-11-16" version="1">MARDKILTSQDVVDLMARDRAVVVYRGNVLDLTNWLQRHPGGDKAVLHMVGRDATDEMIAYHGRDTVKTFMKWRIGRVEGEWENLLPPIQGAKYKSVYTKGDTKLENKLDRSDTSDVSLSSSSSISSMDEKKNTSISLTKSVKPSILTSKGEVNPKVPQNIMISKENKDHIFPLYEDETIVDPKILVEKYDNQLSQDDVLNFPNLDYTTQRRLRKRYNELHHLIIKNGFYKCNYWNYVREIVKLATLFLYSLSFYKLGYLKISALLLGITWQQGTFIAHDAGHLSITHNYEIDNIFGMLIADFFGGLSLGWWKKNHNVHHLITNDPVHDPDIQHLPFFAVSTRLFNSVYSTYYEKVLDFDAPSKFLIKFQQYLYYPILCFGRFNLYRLSWTYIIAGEGPKKGKAAWFRYFEFVGLSFFSYWYFYLMVYKNLNTNWERFSFLMISNIASFIVHVQITLSHFAMSTSDLGVSESFPMRQLRTTMDVDCPEWLDFFHGGLQFQAIHHLFPRLPRHNLRRVQPFVVDFCKDVGLKYSIYGFGEGNEIVIGKLGDIAKQWSILSDAIKKFELDEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2D4</accession>
    <name>G3B2D4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_104515</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685790.1">
        <property type="nucleotide sequence ID" value="XM_006685727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2D4"/>
    <dbReference type="STRING" id="590646.G3B2D4"/>
    <dbReference type="GeneID" id="18245725"/>
    <dbReference type="KEGG" id="cten:18245725"/>
    <dbReference type="eggNOG" id="KOG3363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21940" checksum="837BAC676CBF993F" modified="2011-11-16" version="1">MFKPGISRGFTRRFSRSIPRTDLFGGGKIANPNQQIGAPSGKSETSANPADLFKKNDILMFSTKPINYIESVKPNGFHLSNNLFISSPDTNGDIIGALLVETETYEVNLSKEGFKIINGFLVEFSNDILKVFEKINPKPEILVVGLGKKSRMLSPDNRKYLSSLGIQLEVGDSSHSAQIFDLLSTERPKTIGALLLPPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2J5</accession>
    <name>G3B2J5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial ribosomal protein L51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113481</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2J5"/>
    <dbReference type="STRING" id="590646.G3B2J5"/>
    <dbReference type="GeneID" id="18246981"/>
    <dbReference type="KEGG" id="cten:18246981"/>
    <dbReference type="eggNOG" id="ENOG502R4KN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063080_1_0_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018156">
        <property type="entry name" value="MRPL51_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="351" mass="39096" checksum="A42B56C4C65CD0CB" modified="2011-11-16" version="1">MNNQELFRLFKDSKLAQVAKPLSKVLRGNQSGPTHQIIYTPKSSAIRSNFGIKTALPKQIGFSHIVYNDIDNATSMPDVEKYSGSFYNRIKFQEMNIPVRTEHNTNPLFKSEQTLTPKKAKDVNSSNEDSVSFGLNLKSSTPNKAVKKLLKKNSQFYNQYKEFMLKNYPDKLVSNGARNEHKLVHEFLNTSQDFKKAKSGLLSQKSNRIQGTGGFSYLQKGRLTNTPNGIKYAAMAPGRIIDSRDAAIGGFIASINDNNSLQRNYTKNFPGKHQRQFVIPFQVTDAEVSNSGKVRLEANGVQSGPWSSGLGENSSLYKPTNNNVRGASERMATDMKQFSALLSVLEQPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B305</accession>
    <name>G3B305_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_122098</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B305"/>
    <dbReference type="STRING" id="590646.G3B305"/>
    <dbReference type="GeneID" id="18248880"/>
    <dbReference type="KEGG" id="cten:18248880"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="24"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="692"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="779" mass="87983" checksum="168D869055840C4F" modified="2011-11-16" version="1">MSFSDLIPVVNKLQDIVTTTQVSDLDLPILAVVGSQSCGKSSVLENIVGKDFLPRGTGIVTRRPLILQLVNLKPDEFAACSTSQSNSESDEYYNDDEDDELKEINLEEHLKKLTMAKNGGSKGTSRVSADVEYGEFLHLPGKRFYNFKEIRHEIEIETNRVAGSNKGINRIPINLKIYSTKVLDLTLVDLPGITKVPIGDQPGDIEKQTRNLILEYISRPNCIILAVSPANVDLVNSESLKLARQVDPTGKRTIGILTKLDLMDEGTNALDILKGNVYPLKMGFVGIINRSQYDISINKSLTDSLGDEEAFFRNHQAYRTIANKCGTRYLSIKLNQILMSHIREKLPDIKAKLNTLIGQTEQELIQYGGSPLDVIEDKSVLILNLMTKFAQNFINSIEGTNINEISTKELCGGARLYHIYNEVFGNDLSLINPTHNLTLRDIRTAIRNSTGSRPSLFVPELAFDLLVKPQIKLLEEPSKKCVELVYEELMKIVHNICSNGIEINRYPKLQMKLIEVVSDLLRERLGPTIKYVESLIEINKSYINTNHPNFVGAATAMRTVLEEKRKAGEISKKPVVESDDSDEIEDINEIDEDLPSSKVNESVHIQEKDPSDSYLNYFFGKDPITHQQYLTTQAQLNPAPFKFPNSHETLPLQFNNDSSSTSSTATIINNNNESFEIDEGINELNEKEQLECELIRRLIISYFGIIREIIKDQVPKSIMCLLVNFIRDNIQNQLVIKLYNEKLFDNLLVEDENIQIEREKCYNLLKTYKDAAKIINEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3C0</accession>
    <name>G3B3C0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_122307</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3C0"/>
    <dbReference type="STRING" id="590646.G3B3C0"/>
    <dbReference type="GeneID" id="18248894"/>
    <dbReference type="KEGG" id="cten:18248894"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_4_2_1"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="382" mass="42756" checksum="985686900464B406" modified="2011-11-16" version="1">MKIKPIRMHGIFAIDKPSGISSSRCISDLQHIFTNSAIFQDDLNEMKDNAIKNLSTDKSWSKERINKKVSKIKIKIGHGGTLDPLASGVLVVGLGSGTKRLQHYLGECNKVYETKALLGISTTTGDSEGEILTRNQVDHITADTVKQSVQRFIGDIKQTPPIFSALKMNGKPLYDYAREGKPLPFPIKTRDVKVPNIFIHPDHLLSREHGFEPIKSQLDDNGEPKENALFNNPTLNDSPLYFSSQYLQKCEDEGLPKTVGPPRLTKEPQDRLPMVHLTCDVSSGTYIRSLISDIGRAMESSAYMVELIRVEQSEWKLGKNTFKFEDFHQPESVWAPVLKRVLEEGDKVNVSELMDAAVAAESIALDPDTEESQRKRPITEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3N7</accession>
    <name>G3B3N7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AIM11</name>
        <name evidence="8" type="ORF">CANTEDRAFT_114262</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686508.1">
        <property type="nucleotide sequence ID" value="XM_006686445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3N7"/>
    <dbReference type="GeneID" id="18247344"/>
    <dbReference type="KEGG" id="cten:18247344"/>
    <dbReference type="eggNOG" id="ENOG502SAK0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118700_0_0_1"/>
    <dbReference type="OrthoDB" id="4088121at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="155" mass="17210" checksum="79DD32D61CBF5E65" modified="2011-11-16" version="1">MLTAGFGNFKINEASDEYKLRRRTQMVCFLTAAGITMLTSRFAYKSTITRQFLPTFFQGNHSPPTSYNFTADAAVAVGTGTLLAGSVSSMAIFGWCWIIDVSSFKEFGWKMKSLMGGDERLRQLALQPMDEESASIQDGLNDLLEGKYDDMPDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B427</accession>
    <name>G3B427_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_105347</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B427"/>
    <dbReference type="STRING" id="590646.G3B427"/>
    <dbReference type="GeneID" id="18245803"/>
    <dbReference type="KEGG" id="cten:18245803"/>
    <dbReference type="eggNOG" id="KOG0784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_0_1"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="14">
        <location>
            <begin position="31"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="362" mass="38995" checksum="BA5E954578D9974D" modified="2011-11-16" version="1">MFKTSKTSLRSLATFASPEAVLPKKYGGKYTITLIPGDGVGKEITDSVKTIFKDQSVPIEWETIEVSGIDKNADGVLDGVSQAVESLKRNKIGLKGILYTPTGTSAKSLNVALRKELDIYASLVLIKNIPGVKGKLDGIDFALVRENTEGEYSGLEHQSYPGVVESLKIMTRFKSERIGKFAFDFAKKNNRKLVTAIHKANIMKLGDGLFRQTIKDIAQDYSGIEVNDLIVDNASMQAVAHPQQFDVLVTPNLYGSILSNIGAALIGGPGLVPGANFGREYAVFEPGCRHVGLDIKGQNTANPTAMILSASMMLRHLGLNDHADKISKATYDVIAEGKTTTRDIGGSASTTEFTDAILAKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4F0</accession>
    <name>G3B4F0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_134389</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686121.1">
        <property type="nucleotide sequence ID" value="XM_006686058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4F0"/>
    <dbReference type="STRING" id="590646.G3B4F0"/>
    <dbReference type="GeneID" id="18249790"/>
    <dbReference type="KEGG" id="cten:18249790"/>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014743_2_0_1"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442764" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="325"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="710" mass="81659" checksum="6EE3396C16A239BC" modified="2011-11-16" version="1">MKGFSVLLLASTIAAHAINGMSSIKTQLHKRDELGLIEQMYSDLPFPDQDFITNHLSTLQAFNGSKCDACKNKIHYARKLYDEDPDNQHLIAFTLFKYCIASNKDDPTKCDTVDFFLTTQSNLINIAANKYDSSFGDETSVNLFDNDFMHMLRLFNLSSELDLDYYCYFKGGVCDLPETIDIDSEYNFDSKWPVKQPHHYFEPEYTNGSGDTFNVLHITDFHSQFKYTVGAEGNCSQKICCKVESYNEDLPDMSNYNFTEAYSELCPNGDIDNFAFYPDAKYDDQGNYSPGEYYDLPEGRGWDSVVQPAGVWGNYECDSPVILINNTMKYVRQLQNKNFEFTLFTGDLVDHDKIHDTPAITKEAEVLGFKILKEYLGGIPVYPSLGNHDTFPYGQLAPQKYDPNSSYQYNAELMSEIWVNDGWLDRSEQNEVKEHYAGFSHVTKRGLKVISLNSNAYYQKNMWNYINLREDPDRFGQWEFLINELVESEQKGQRVWIIAHIPSSDGDALPIQSRIFAKIVERFSPYTIASIFYGHTHRDQFKVFFASNSSSAEDVERDVTNMAWIGQSVTPLSDYNPAFKYYEVQDGSFNIMNSYNYYTKLNDTYIEGSAEPAWEFEYSARETYDPNSTWPSTAPLNGTFWNQYVLQKLADNSSIEFNQLYTNLQYRSTLNTPVCDDDGKLSTDCYQQNYCEAGSYLSDEYLKCMNQLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Q9</accession>
    <name>G3B4Q9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_113876</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Q9"/>
    <dbReference type="STRING" id="590646.G3B4Q9"/>
    <dbReference type="GeneID" id="18247158"/>
    <dbReference type="KEGG" id="cten:18247158"/>
    <dbReference type="eggNOG" id="KOG2862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_5_2_1"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="33"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="384" mass="41101" checksum="56907C58215A7941" modified="2011-11-16" version="1">MSSVPFKQPAHKLTMIPGPIEFSDEVLYAMATPSQAHTSPEFIKTFQSTLINLRKVFKSTDPAAQPFVLAGSGTLGWDIAATNFVSAGDKVLVLSTGFFSDSFAECLKIYDIDVDVITAEVGDVVPLEQIEAQLKKEKYAAITITHVDTSTSVVSDVGAISSLVQKVSPETLIVVDGVCSVGVENLEFDKWGVDYALTASQKALGVPSGLSVSFASGRAMEKALNRPKQTSFFASLKRWTPIMKAYESGSGAYFATPAVQTITALKVSLDQILSETLDKRFASHAQSSDEFKGELEKLGMKILPVSRSVAAHGLSAIYFPEGVNGPDFLSKLASKGFTVAGGIHKALPGKYFRVGHMGYSVRAGHLDLLLAAIKESLSELGYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Y8</accession>
    <name>G3B4Y8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_114055</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573</strain>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Y8"/>
    <dbReference type="STRING" id="590646.G3B4Y8"/>
    <dbReference type="GeneID" id="18247235"/>
    <dbReference type="KEGG" id="cten:18247235"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="51"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="388"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV64327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="583" mass="62514" checksum="62FFB9B198128A23" modified="2011-11-16" version="1">MKQFVRAFAQTAMRSSKKLNKYSSIVTEDVSQGASQAMLYATGFTDEDMGKAQIGVGSVWWTGNPCNMHLMDLNHICTASVNKAGMKGMQFNSIGVSDGITNGTEGMKYSLQSREIIADSFETMTLAQMYDGNIAIPSCDKNMPGVLMAMGRHNRPSIMMYGGTILPGETTCGQNNPNMPKKVDIVSAFQSFGQYLSKQISNEERMDIIKHSCPGPGACGGMYTANTMSSAAEVLGLSLPYSSSAPAVSAKKREECDNIGYAIKHLLEIDLKPRDIITKTSFENAITYVIATGGSTNAVLHLIAIASSFDIEITIDDFQRISDATPLICDFRPSGKYVMADLHDFGGTPAVMKLLLEEGFLDGSQLTVTGKTIAENLKELPGLPEGQDIVRPINNPLKSTGHLQILKGSLAPGGAVGKITGKEGTYFKGTARVFDKEEGFIAALGEGQIKKGEKTVCVIRNEGPKGGPGMPEMLKPSSAIMGYGLGKDVALLTDGRFSGGSHGFLIGHVTPEAAVGGPVGLVEDGDEIIIDAENNRLDLLVSEEILAERRKKWSPPEPRYKRGTLFKYSKLVTDASKGCVTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B507</accession>
    <name>G3B507_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RA-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_114066</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B507"/>
    <dbReference type="STRING" id="590646.G3B507"/>
    <dbReference type="eggNOG" id="ENOG502RXZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021546_0_0_1"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="322"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46422" checksum="7E4DF4791A3E4ACB" modified="2011-11-16" version="1">MSVLHSSNDSFLQWDPAQVSIYINSVSADDSNTIGEYFLENNIEGSLLPFITTEHLKELGIEKLSTRLLIKNKITELTNAHYEKNPPKSYNDPDYRLSNININNNYVNFECLTLSSILMKDMIKKLAVTVQQHRSATSSPTTEQDIKKLNENFTRLKSDLIPVIRLLKDSKPLPTPTLDPGPVGQNLDSPTYSISSNHSTNSNTLIETFQDAGFLNNSQSNSNRNSNPIPSPTQSNRFSSGSLLSLGTGKIASSGGAVGHPVEQAKSSTPRPRLVESKSTNAASTSILNIPKTLRKHSASTSSASTPSLQQQPPVANNEPLKQLRASSEDSCLKILQQAMKRHHIPRGDWSKYVLVICYGDKERILKLAEKPVPIFKELQELGKHPAIMLRQLADTKTADTNSNEMYEDSRIGDDIPGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B525</accession>
    <name>G3B525_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_105870</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686911.1">
        <property type="nucleotide sequence ID" value="XM_006686848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B525"/>
    <dbReference type="STRING" id="590646.G3B525"/>
    <dbReference type="GeneID" id="18245847"/>
    <dbReference type="KEGG" id="cten:18245847"/>
    <dbReference type="eggNOG" id="ENOG502RS0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014756_0_0_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="5">
        <location>
            <begin position="154"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="828" mass="94237" checksum="295C1DFCE886803A" modified="2011-11-16" version="1">MNTGVDQSKVIADSRILYDLSGLITNISKYTIDDVKSILGTFGALISSEKQQINISKLSNITSLLLFYASPLSLTIVDTVSLIRFLYESSEGVSNPDEEEANDIEEFAHYLAQKTNDDGLITDELVVQAAQVILQNLETRNESFGFNIEGVDLDTIVFHTIQKRLWINSIYIDDIELPKELLSLDTSAACRQWYASSYVPFKYYWDNHGSIAPSPTMKFHEFSQMHTADAIFESLISPVDSNSYSNKLRLGNWMSHVIIPALDAYTLDPLRKWMFEHERTKTSTISEKQHLWNIIFNSLITADIPFAKYEDIVETYIVSCYYDTTADNLPKVSSMETLKVLDLIKETVDLLVPVVPQTAQIVTVNSISYDKNLTFNSIDDFKANTPLRPLLVANKDCVVTLSETIETCRKLYPINQTTVAKFLELKYTPGSHSEELKREVTKLLLGLTPTSSQQLLHSLNLFKNVFTQNDDELEAIDGLVVDRFLFKDLFEYVNQLYDGGQLKIKPDNFVQLLLKKFWDSVNQATNFDERIGKLHSATSCITLFNKLSANGDLTSQEREEVTRLKHLMKVFANIRNFKLQFERSKAPTPLDIIKRFGSLPAHEELRTELEAISPMGLITTILEQNLKSYLAFEKLFKVLSDFLLFLKDTNVTSSYYFQRLMAACIEASLIDNNFSYAYKKSLELLSQYEDDNLNNMWMTFYQVGNYKSPDWAVDETIDSNRVEVLLKQSEILSKYLRVITRADVSTDNSRIIVEQWEKVNHNIDGWYQQVESQKANTSKTSTRQIQENFTSTANEILGDAANTTAQASEKLSNLFVSGLGWAIGANPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5I7</accession>
    <name>G3B5I7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_105926</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5I7"/>
    <dbReference type="STRING" id="590646.G3B5I7"/>
    <dbReference type="eggNOG" id="KOG3005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030739_1_1_1"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="276" mass="31590" checksum="C6A941D98BC37F9D" modified="2011-11-16" version="1">MSQDERHLSQLSQSNKTVHVIPFYTVYLLQSGPRLQSFYIGSTPNPCRRLRQHNGELQSGAYRTRKDGFRPWHFAAIITGFSSKISALQFEHALQHPHSTRHIPDNKRVSRSKSGGRSVHLKLANIRLLVSSRYFGHLGLCVNIFSFHILDVWNANKHSIEYENMRFWDKGYDEFVGELEVGDFHMVKDACENLQNKLMQITHCTGCGGSIDMMPEHEQNSLPLPAITLCVCQNVYHLRCLSDEILPKYVHCKICGGKSDWFRLAMVATQARSAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5L1</accession>
    <name>G3B5L1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5 13">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_123255</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5 13"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5L1"/>
    <dbReference type="STRING" id="590646.G3B5L1"/>
    <dbReference type="GeneID" id="18248948"/>
    <dbReference type="KEGG" id="cten:18248948"/>
    <dbReference type="eggNOG" id="KOG2436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013088_0_0_1"/>
    <dbReference type="OrthoDB" id="5585968at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="383"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR007892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="559" mass="63897" checksum="047AAE8AA4241BFD" modified="2011-11-16" version="1">MSKPSLTRQLTSNLVLHESSTNSKRNLILSILRSTTTKRETKNYLNKYRNQFRYNDSSAPDKDMQRSIFINRFLQQKNPFTNIYDEEEKKLQKIPLRIAIFKLKFSNVDPQNWAGIQETFKRLINLGASPIIVMDHDDELINDFKLNEFALINQGNRLLNSLKEINPRLIRTLFYRSEKGEMKINSLEQILIPMYQGFVPIIQPIVFDSLSSNQQFLKSDELLLSLCKSVLSANQDDMLSIEKVVFVDKHGGIPSIERNQTSHVFINLSQEYSDIISELYIGFLEPSLRDLHIENLKSIDKLLTAIHDITGNDETTGIITTPGIISINNDQLNPIIYNVLTDRPIISSSLPSSFKRTPQLSTSILKKGIDVEVLEPRNYPKEFTLENLINDNLVDKGKFFHLIEDSFGKPLDIDAYIKRINKTITTIIIVGDYDGGAVITNETSDGKTVPYLDKFAVAKKNQGLPGLADIIFKLIVQSNPDELIWRSRKNNPINKWYFERCVGSAAKAGSKWKLFYTGDIFNKSVQLKKKRDSININEKMKTYSSICESIPPSFTEPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5N6</accession>
    <name>G3B5N6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114566</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5N6"/>
    <dbReference type="HOGENOM" id="CLU_1081814_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="257" mass="29931" checksum="654E6C19FA0D3F10" modified="2011-11-16" version="1">MDLQHEIDIPLNPEDPISSHEIKDRLLDEWEGKMLKSFRDYDEWASQMTTLMKSINPKFINYINGELSESEIGQDEFKRSLDYLYTLFRLSMSDEIFKDSIVDNFTPVKLWSHLKDRYEKLSKNYYSSQQKIMEVLTDTSTTGDMKLDSLLAFPQDIFKIIEFDVCRELVTYSKDSIITLAYNILIKNEVDMTLRSLQEEVKVIKSASDAAMDERCAKCQRSGHNHMMCTNELWCNMEGETLSIPGSENLFPPPNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3B618</accession>
    <name>G3B618_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114667</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B618"/>
    <dbReference type="HOGENOM" id="CLU_2793751_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="68" mass="7714" checksum="7760C58D8939EBF7" modified="2011-11-16" version="1">MCQNRPPAVKRTSVCRGDTDVLCLQAPNGPVRSLYVFVTCTTPTPTTRCATRRFFLKKSSYSHYFKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B691</accession>
    <name>G3B691_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94168</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687209.1">
        <property type="nucleotide sequence ID" value="XM_006687146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B691"/>
    <dbReference type="STRING" id="590646.G3B691"/>
    <dbReference type="GeneID" id="18250369"/>
    <dbReference type="KEGG" id="cten:18250369"/>
    <dbReference type="eggNOG" id="ENOG502S1HU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077719_1_0_1"/>
    <dbReference type="OrthoDB" id="3994490at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="214" mass="24917" checksum="AF76184E6532FED2" modified="2011-11-16" version="1">MASYTKVSRSSLYESGDELQDNPTYIPDLNLEIIEVEHTEDLKEEQPEDEFDFPLFSFGSAPSSQNHSVGDSQKRGRTETKIMKVNLREESVETLRSERPSSYYFAQYTEEQRANFHLVAVTGEDIWSRVELATSTNDWYRHRILDADVHNANISPERPSRKRPGKNKRDGRIESKKRQAEARRVHRENERRLLKKKMHKRGGKKNKKAAKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B693</accession>
    <name>G3B693_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial complex I NUIM TYKY subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114720</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B693"/>
    <dbReference type="STRING" id="590646.G3B693"/>
    <dbReference type="GeneID" id="18247551"/>
    <dbReference type="KEGG" id="cten:18247551"/>
    <dbReference type="eggNOG" id="KOG3256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_2_0_1"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="218" mass="25334" checksum="B576F15FA9619347" modified="2011-11-16" version="1">MFRLSTQVPGFARGFSTASRLFKPVANEYLTTGSSTQSIWPKGFRLPQPKSWEESSESALSKATKFFFLNEIARGMYLCMEMYFREPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERMDGSRRTFKYDIDMTKCIYCGYCQESCPVDAIVETPNVEYTTETREELLYNKEKLLENGDKWEQELQYCIDADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B741</accession>
    <name>G3B741_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114403</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B741"/>
    <dbReference type="STRING" id="590646.G3B741"/>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_1_1_1"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="204" mass="23144" checksum="6B87443D12C6AC0B" modified="2011-11-16" version="1">MDPVDEKRDIWISKSLSYLLRHGAKKEKLEIDDHGNVEMQHLLNHNRIKCRHVTLEDVKRVVTNNNKNRFALKQHNGKLYICAQNGHSIGISNQNLEKLEPSAVPAGLFHGTYKAKLPAIIASGGLSRMNRNHIHLTTNMNYVRPTCDILIFIDTEKCVERGIVFYKSGNDVYLTEGLGGIVGPDLFRRVEERLSGANVQYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B762</accession>
    <name>G3B762_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_105855</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B762"/>
    <dbReference type="STRING" id="590646.G3B762"/>
    <dbReference type="GeneID" id="18245845"/>
    <dbReference type="KEGG" id="cten:18245845"/>
    <dbReference type="eggNOG" id="KOG3101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056472_0_1_1"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="289" mass="32188" checksum="13498023C1A532D5" modified="2011-11-16" version="1">MSFKVEAEISQFGGKLYKLSHESTSTNTKMDVNVYVPGSSPKTKIPVLLYLSGLTCTPNNATEKSFLQYFAGKYGFAVVFPDTSPRGANIEGEDDSWDFGTGAGFYVDATEDKWSKNYNMYSYVHKELLTELEKHFSALDFSNISITGHSMGGYGALAGFFKNPGQYKSVSAFAPISNPSSCPWGEKNFGNYLGSDKSKWEEYDPSHLIKKYAGANQPDILIHQGAADPFYFRDHQLQPENLVAAAKDSNYKGKVLLNVVEGYDHSYFFISSFVEDHAKHHIKYLGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B770</accession>
    <name>G3B770_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_115043</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B770"/>
    <dbReference type="STRING" id="590646.G3B770"/>
    <dbReference type="eggNOG" id="KOG3924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821354_0_0_1"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="12">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="338" mass="38582" checksum="F3BDFC4E56C95923" modified="2011-11-16" version="1">MLYLSPTYKGNELLSVDVNPEIREFVTDSFTKPTAGDLNLKDFYNEVCNKPPASMENETEEDADPEIESELQFETMLEEQPLKSATEVVAGIERPKTYIQDFFNGLKSKTTISRYCMQQLLIRVYSRVVSTRSRELRRYKAFTAEVYGELLPSFVSEVMTKVDFKPNQKFYDLGSGVGNTSFQAAIEFGAAFSGGCELMEHASRLTAIQKLVLDKHLKIFGLKPLNLRFALAQSFVNNPVVKNDVLDCDVLIVNNYLFDMKLNFEVGRLLHGLRPGTKIISLKNFITPRYKSTGDNTVFDYLEVEKHEMSDFFSVSWTANKVPYYISTVMPTIRDQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B795</accession>
    <name>G3B795_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115060</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B795"/>
    <dbReference type="STRING" id="590646.G3B795"/>
    <dbReference type="eggNOG" id="KOG1740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1246209_0_0_1"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="244" mass="28178" checksum="70F972DC91D09C36" modified="2011-11-16" version="1">MARQNFVGLVVSQGKMHKTVKVRVQTKIHDAKINKDVFKRKDYLVHDEGNLCKEGDIVRIESIPKISARKFFAVAEIKVDKGQQFALYEKLAQEKVAQEESQLVKEFVSRRENLQRVITKIEDLKALDRIVHTAQTDPDASREALVKQINEIKQKYNIDSWPTDKPVLDLELTSDKLELAEMQTRETHIHRILDALMSDENAGVRKEILSKVAKKNVDELKPGIQKNILRKYVLDVRNEVPIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7B4</accession>
    <name>G3B7B4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_115071</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7B4"/>
    <dbReference type="STRING" id="590646.G3B7B4"/>
    <dbReference type="GeneID" id="18247708"/>
    <dbReference type="KEGG" id="cten:18247708"/>
    <dbReference type="eggNOG" id="KOG0631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_6_2_1"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="15">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="13">
        <location>
            <begin position="118"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="14">
        <location>
            <begin position="407"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="509" mass="56453" checksum="135BC79505B0F3CD" modified="2011-11-16" version="1">MSDLVPTFHDLSFYPTVETQTTRYNNLVKSFADHFSGEKPAFLARAPGRVNLIGDHIDYVYFSSLPMAIENDLVAAVSTTNNFAVNVINTDTKYEATTFDLPQDSLLTINKEAFHWTNYVKCGFLVAAKFLHDKHGYKYSDFKGLNIVYDGTVPTGGGLSSSAAISVCSALLFLRANGYTSITKLDLTAITVVSEHYLGMNTGGMDQCASVYGEKSKAMLVHYQPQIYGEIFAFPVIKPYDMVLLISNSLVEANKVETAPTNYNLRVVEFAVAAELLAKRADLKLVADSSLGTGTFRGFLDNYCEQKLGWPHWDGHNIDQALKMFEAILQVVEELYTPEERDGFTTEEAATDLGLTTEQFTQRYLSKYPVRYEKMKLYIRSKHVFTESMNVFRVLKLLSSEPKPTFLQELGQIINDSQYTCAHGVQNSTADIDQICDIALKNGSYGSRVTGAGFGGSVVHITTTDKIDQLTKALTEQYYQKNFPGITQETLDSALIITKPSAGASLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7C1</accession>
    <name>G3B7C1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115081</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687791.1">
        <property type="nucleotide sequence ID" value="XM_006687728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7C1"/>
    <dbReference type="STRING" id="590646.G3B7C1"/>
    <dbReference type="GeneID" id="18247711"/>
    <dbReference type="KEGG" id="cten:18247711"/>
    <dbReference type="eggNOG" id="ENOG502S442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111698_0_0_1"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="199" mass="22643" checksum="7AC5489C9345B34A" modified="2011-11-16" version="1">MDILTYVPQDKKLVFQDDGPVDPKLKLDVDQLNTLIAEIIANGSDVPPIATPQNFNTDLSKVVKRLYEGGVNAFKKEKYDDSVKQFSIGIEMICRRHKFEAFQICLQELSMFLMSRSDANLKTKDYVAAFNDVDMLISMQMVTPDNFLRRGVANFFLGNYEDARADYQRGLALSPGNQRLQAELEICLDKILEENGDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7F6</accession>
    <name>G3B7F6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_131639</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7F6"/>
    <dbReference type="STRING" id="590646.G3B7F6"/>
    <dbReference type="GeneID" id="18249544"/>
    <dbReference type="KEGG" id="cten:18249544"/>
    <dbReference type="eggNOG" id="KOG3689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="4">
        <location>
            <begin position="183"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="614" mass="68917" checksum="40012040D6D0A16F" modified="2011-11-16" version="1">MAEVIANTSRRLPLLDGIAASSLSGTTVTHVTYEASFQKVVEMLFRKGNSESDTDCLTLVVIEQPTVSSSSRLDSLSFDDKLLLLKYYFSHLNVVALEARDITNETALKIKKWIGQINTLIHDRISRIQTWTGTAAIRINDSYTDDKQIGEIISTMSSVLTCAVSTSPVTIQRITGIKDAIIHDIDFLSLLSQNSTSHLSKLCNLVGHWSFPAHELSNDDLVYCVYLIIKYCLVQLEHESSATHAKIALGRNELLGLIFMVRDSYKNGNPFHNFRHAVDVLQACFHYVIRLGYLSPFTQFQSDPKADELICLKAEKFGNAVELISMKAATRVPPTSSAAETPDTEDTSLNLVSTLALLVAALGHDVGHPGVTNQFLVKHSSPTSLVFNERSVLESFHTSVFLNKILVVNWPQFLQLKIDTNLKLIVKELIITCILATDMAEHFDYIDKLNKFNDIHHHHHHHQGTYSTTDSTSSASSRTIANSFDIQNRTNQVKLISSLLIKCADISNVTRPLRVSAQWASVLSREFDEVSKVEEKITDSGKQFSIKYDKVPMFLVDILQANPTIHKGQMFFINTFAENLFNNISELLPPLKFTGEIVQENKDYWLKRDSNRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7P7</accession>
    <name>G3B7P7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_131656</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7P7"/>
    <dbReference type="STRING" id="590646.G3B7P7"/>
    <dbReference type="GeneID" id="18249548"/>
    <dbReference type="KEGG" id="cten:18249548"/>
    <dbReference type="eggNOG" id="KOG4126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008539_6_0_1"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.140">
        <property type="entry name" value="Alkaline phosphatase, crown domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042085">
        <property type="entry name" value="Ap_crown"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442801" description="Alkaline phosphatase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="481" mass="52680" checksum="2A2243A0B52FE308" modified="2011-11-16" version="1">MTVLRLYIIISALFLWSAATPVPTFGKKNIIFMVPDGFGPSGLTMARDYRRTQLGLANDQKYTLNLDPFIIGSIRTKSNSSLITDSAAAATTYATGFKTYNGGISVDSSGTAKTTLMESLKSQGYKTGLVVKSTLTDATPGVWAAHVSKRDKQSQIAEQMLEGGIVDYMSGGGKCYWIPKSETGSCREDDRNLITEAKDRGFTYFESRSEFDGHLAEGLSLPALSFWAQEDVDYAIDYNNSITPTLPEQALLALKTLEKATEYSTKGFFVLIEGSLIDHCGHDNDAACHTREVLEFDETFKVVKDFIDGTDTETIVVVTADHETGGLTLGLDDSSTYYPEVLFNKTHSSLFFESKVIEFNETNPQAAELTTFVQNWVATELAVTDASDEEIQTVVDAVTSDGDIRAAIGPITSNRASIGWSTGSHTASDIFSFFYTNSQQIQQNVFNNEPGWELRGSHENVEINRFLRTVGDVAQESSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7S8</accession>
    <name>G3B7S8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RecQ mediated genome instability protein 1 OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_108251</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688482.1">
        <property type="nucleotide sequence ID" value="XM_006688419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7S8"/>
    <dbReference type="STRING" id="590646.G3B7S8"/>
    <dbReference type="GeneID" id="18246016"/>
    <dbReference type="KEGG" id="cten:18246016"/>
    <dbReference type="eggNOG" id="ENOG502SXZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112152_0_0_1"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="1">
        <location>
            <begin position="11"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="190" mass="21296" checksum="77584C9A795E762E" modified="2011-11-16" version="1">MSNPERNAFNPQEFANKPSDQTRLPVAFNVIHVDDISKSKIAKLEEWMKYKDPNEVGVDRLNRSGAGTNQHIIREIDVSDNDNARLMETTSLFDSSVYKLTLRDNFDNYCFAYEYNDKLPFLRTGSTLPIPIKLGGKLIISSGATVANGALLVDRKVCKYIGVDESSELVKALNSNLVEKSINILQNPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Z9</accession>
    <name>G3B7Z9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Antioxidant and copper/iron homeostasis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_107275</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Z9"/>
    <dbReference type="STRING" id="590646.G3B7Z9"/>
    <dbReference type="eggNOG" id="KOG1603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_3_1_1"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="74" mass="8091" checksum="0628BD79A9EEA3D2" modified="2011-11-16" version="1">MSGHKFHFEVAMSCSGCSGAVERVLKRLDGVDKFDVSLEAQTVDVETKDSVDFDTVYQTIAKTGKSIKKGSIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B861</accession>
    <name>G3B861_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115821</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B861"/>
    <dbReference type="STRING" id="590646.G3B861"/>
    <dbReference type="GeneID" id="18248037"/>
    <dbReference type="KEGG" id="cten:18248037"/>
    <dbReference type="eggNOG" id="KOG0176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_2_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="255" mass="28069" checksum="FE88757EF967A59F" modified="2011-11-16" version="1">MFLTRSEYDRGVSTFSPEGRLFQVEYSLEAIKLGSTAIGIATSEGVILGVEKRVTSPLLEHSSIEKILEVDRHIGCAMSGLTADARSMIDHARVSSLTHDLYYDEEIQVESLTQSVCDLALRFGEGAGGEKRLMSRPFGVALLIAGIDKQNGPQLYHAEPSGTFYRYDAKAIGSGSEGAQAELQNEYHKSLTLKEAELLALKILKQVMEEKLDCKNAQLASVTAEKGFRIYSDEETDEIIKALNEQQAETEEAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8D1</accession>
    <name>G3B8D1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115828</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688538.1">
        <property type="nucleotide sequence ID" value="XM_006688475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8D1"/>
    <dbReference type="GeneID" id="18248041"/>
    <dbReference type="KEGG" id="cten:18248041"/>
    <dbReference type="eggNOG" id="ENOG502SY6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363686_0_0_1"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="74499" checksum="0ED05965504BB680" modified="2011-11-16" version="1">MNQQTIQLYGQIFINDSSKIPDFYKTFYSTLVHFESLKSTLVANLSATHLDSDADVNQQLISLFNHGIAIFKEVSQYTPTPLSTSNGMSRDHLEEDDITNIKPKPMPLLLNAVFNDMDDELRFELIANVLRILRVILSSVVECHKQSELVVTDRIDYSLLFRMVYWFLERLVPNLDLEKVNQTLLVIMKEIVYLVYDYMVVITVQNTDMLNEFRRSNYADLLNQILIKTHPNFANNILDTRPTVSLSTKTQIRVFVSLGILNNDNQVQINYSDEDKFAAFLNQFEPLLQYSIKVCYDYNNDLTNHQIMNASFFNWMTANLLNFSNEYLNDSYIRNIYINNDDIESLLNIRIKQYHNFGHDYFESLEFFPISLYINGFCNQVGFLEKFLETDAAASWLCLASYVLTYQFKSKKSVLATRLVLHMYDKFLKSPNILSVTINEFKWKLCHQRAPILPFNKANNKHKPWVSYMLDNLVILLRFNLNRKLNVPNFVNAIKLITLIVLTHVDENYHYEDLFKSMVNLLNFNETHLNSREIRTELLQSFEIALGMSIRSHLVYHVLLMFDKFEPLSLEGLPNLTHLKTFIMSKFDIKGDDPSKIKLLDSDFESPELQQTIKQFGPVAKTSTLVPKVKIGLNDIIVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8K6</accession>
    <name>G3B8K6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_135694</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8K6"/>
    <dbReference type="STRING" id="590646.G3B8K6"/>
    <dbReference type="GeneID" id="18249899"/>
    <dbReference type="KEGG" id="cten:18249899"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029455_0_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="360"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="547" mass="61274" checksum="89530178278DE4A8" modified="2011-11-16" version="1">MVFVLHTSSEAQINMEDAFFLTKNSLKEFRAQYFPNKHHKVPDVRPTDSVSIDSFGPSYDEIQYPLNSIVSSVFPIDSRIELNTTSDYYELVARYASFSPILNFPLMGNYKTLAIDACNSTELNGLDLQEYQFKVLVVVRGKCTFVRKVENILKSDLDPKAIIVANDEPSRGLITMYSNTFNEDRSLTVPIMFITQESYDTLKRFQDQNLVIRILTISLGSWVNIMVSMMLSPPLLILFFYCLIQVLQHFRKVRQSRQSQKIVKNLPVYIYNKNHLIHCKTFYKYLKTTGQTEQILSESLNSSSSSLAANDSERPVAKPTPSSSNASMNNFKVNGIDLKRNVKSLGILLMNEDFYPSFKCSICLDRFKPLKSRVLVLDCKHFFHEGCLSNWLINFRRSCPLCNRSVFENVSTTLIAGQLGVQSYGSVSDEESNIAIPVNEIITTGTAEPFENLSISGPSAELIPNHPPHESPPNPGSLLTATSQSTVSTNTISSFITSNTHFNDQSSIQTGSSTFATASERTTPVDSISTISSVSDEATINLSQFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Y5</accession>
    <name>G3B8Y5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_124983</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Y5"/>
    <dbReference type="eggNOG" id="ENOG502QPKA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF8">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="217"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="394" mass="45445" checksum="5988221540FE5670" modified="2011-11-16" version="1">MLSFKRRFYLPISYAKILISHLIRCWLNNRTLLQTVVVIIRNCIPLCVWLLLFNTMNLIPNSVKPRINVRLVMRLDDYVFQTWQGGVLTVLCLFLGGILVFGRFYSPTTVKSEPRSHVIALSDLEANKAAPVGQVQPSQDNDTAVASPICSWDRFPVYSMMLGWVILNGIYSFKDPINKAKNIVALVFYLMGHVLVVPATAWYLYLFQPSRILKLFVIAIGVQSICVNITHLVFPNVPPIYIQYYGENKNATYDSPGYSEGLTRIELNFPFGRVLNFFIIYVKSIEFGILPSLHSCMSLTSVYFLVNLISIRVMKVALLVYSCFQIWSSLYLDHHWRVDILFSVFYSMFSYLMVKDKLVSIRSQFRYDAKFGRETTMGMRVFHGTGLEWWFTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B905</accession>
    <name>G3B905_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zf-CHY-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_125016</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687993.1">
        <property type="nucleotide sequence ID" value="XM_006687930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B905"/>
    <dbReference type="STRING" id="590646.G3B905"/>
    <dbReference type="GeneID" id="18249069"/>
    <dbReference type="KEGG" id="cten:18249069"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013368_7_0_1"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="355"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="425"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="492"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="719" mass="82702" checksum="202CCC77ED9285C2" modified="2011-11-16" version="1">MEKDVSTTHQDHEFPSQSASDVESISSDDSFTTQLDQIGRLNLLNSLSFSSYLPNLALELPSFDYKRIPDLSDTRKFIRSYTSAFSSDGNPHRHISSIRTIISSRLQMTNILNDLNLGISLASAIDRLQPLKDVIREAVMLPVDDDYVPAGPEAEVVTEPTGIADIVSEQDKTPFLNELVIPEEDLREHQRHHQRYHQGSKRRKRARQVRSAESSRVSSELDIEGLSLEETRELTNLDSLDDLYKERVLRNKIQKIQRLDAISQVSKNKLVTRLMMGNYYKYVNERLSKDDQISDLSQLKLPSDNEDEEDDYGEDEDETDSCLESAPLPHDEIEVSEEDEVMLTEKDKLPSYHDAHHQVLGCPHYQRNCKIECPTCLKWFPCRFCHDQVSDHKLVRSDVRHILCMFCTTPQEPNEQYCIECEKELANYVCFKCKLYDNDYKKDIYHCDKCGICRLGLGLGKDYFHCDTCNICLSIDLKHSHKCLNDTTHCDCPICSEYLFTSVTKVVFMKCGHSIHDLCYKELTQHSYKCPICKKTVVNMDTQFRILDQEILQQPLPLPYKLWRCIVSCNDCKGKCNVAYHLLGLKCKYCNSYNTTQLKLIKPEEETEDEVPGNDSVDRMKLVQTSLSDNFLIGNDVDHDGEGHNRSLTEGESELADVSDEDDKAHEQNLVNIKRFTHRLLNRSGDNEMSYVTSLFQRYINQTLKSDGETDTSKEMPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9F1</accession>
    <name>G3B9F1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_94746</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9F1"/>
    <dbReference type="STRING" id="590646.G3B9F1"/>
    <dbReference type="eggNOG" id="ENOG502RK5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1120034_0_0_1"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="248" mass="27819" checksum="8ACDF10BF3B60C19" modified="2011-11-16" version="1">MPTGQNNMKWQKPNSPSEGSHNIPSYYGETGPYERYPNSEPKNGDSGTHPSQTHPLPQPRPSTTAYQLPPYQLPQQHQLPGIAPLGIGQIYEYRLPVQGQEMMVPAAPPTMGPSYGYSHKYMGQPPRPESNRTSKPRDSPPDNLRPPTSSASSPGSAKAGRNPTKRSRMGCITCRQRKKRCCETRPKCTECSRLRLNCAWPTPGTEHKNKSKELKEEENVMHHEIYGKIKVLRGIVEYKSDEDPANMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9L3</accession>
    <name>G3B9L3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_107330</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9L3"/>
    <dbReference type="STRING" id="590646.G3B9L3"/>
    <dbReference type="GeneID" id="18245947"/>
    <dbReference type="KEGG" id="cten:18245947"/>
    <dbReference type="eggNOG" id="KOG0733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_8_2_1"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000110">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="227"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="566"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="835" mass="93029" checksum="B10F20D00A4E4988" modified="2011-11-16" version="1">MKKGAVSASIDQKIYDLIHKLLEERTEANKKVNVDKDSFESIALARDLSLSDILHYVQLKDFQLRRMKRNTVEKAIQEVLKIVREDEQEELSDVIKYRDDLGSQKPETNESDSDFENADESNMMVVKDSNALNKSVVSSWGVTPVAIESNDEEKKNDEEKKSDEEKKRKRKESSTKVSHKKKKIDHTPPDINLSQLGGMEKVTTQLMELIGLPILHPEIYLSTGVEPPRGVLLYGPPGCGKTTVANALAGELQVPFISISAPSVVSGMSGESEKKLREIFEDAKNIAPCLVFIDEIDSITPKRDGGAQREMERRIVAQLLTLMDELTLDKTNGKPVIVIGATNRPDSLDPALRRAGRFDREICLNVPSEEQRISILKAMTSTLKLNLEGFNFKVLAKLTSGFVGADLKSLVTASGVFAIKRIFETLSEQQELEELMKNGSLDNNSMEVDQKVTPAVTSAVSNSKELVETFENKSDDEKLSIIQKFLISHPSPLTEEQLQPLSISFDDFMNALPSVQPTAKREGFATIPDVTWDHVGALTKIRMELHMCIVQPIKKPEIFEKVGITAPAGVLMWGPPGCGKTLLAKAVANESRANFISIKGPELLNKYVGESERAIRQVFQRARASVPCIIFFDELDALVPRRDASLSESSSRVVNTLLTELDGLNDRKGIFVIGATNRPDMIDPAMIRPGRLDKSLYIELPTEEERLDILKTLIKSNGTPIDESVNLKDIVYNQKCRNFSGADLSSLVREAGVIALKRKFFHHQKVGDLDKSGFMETEDLVDASDIFVTSNDFLIALDNIKPSVNDRDRAKYERLNKKIAPVIGEPQELKDSEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9N5</accession>
    <name>G3B9N5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_135859</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9N5"/>
    <dbReference type="STRING" id="590646.G3B9N5"/>
    <dbReference type="GeneID" id="18249911"/>
    <dbReference type="KEGG" id="cten:18249911"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015116_0_0_1"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="105"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="525" mass="58883" checksum="3521B166D3BB4747" modified="2011-11-16" version="1">MSDASTPTTLLVVFLVCSFCALLIAVIVIYKCAGADSTRGYVRVGNIIVDNTNLPTEFLNDEEALVGLSEEYDFKRLSPEEQSSFLRGEQFTRDNPPEFHNTRGRSISREDEIIIKERGVNAFEFEQDADSLQPRYIVEDKTEINFLDNNSPYSTATSVLNYSLPVKNRSFSDCIYFETKVFEYSNAGNPNAHFSIGLVTKPYPAGFRLPGYNNFSIAYESTGNLKINKPFPTPLQQHWGEQSFYNALVLPPLLQSDIVGFGYHVLTGTVFITRNGKKLMDVMKGLFVDMYPAIGCFSTNAKFQVNLGQLGFVWIEANVKKYGFISTSDYKRIRGDRGLASLPQYGTSSSLRGDQLLDKGDELPPKYPEDELDFFGRSRNLIASSSKHGNINDFDEKDDAECKSKITHEPEEIMDLRERLYEQNITFESDSSQQSDAERSPLLETSPLLAKSPNYGSSKENSKSSEDISSSRVLNSSWEGTPTGIASSQEIANPQLEGSSHSHTQNRSNNVKNKKKKKSKKSHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9S8</accession>
    <name>G3B9S8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115414</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9S8"/>
    <dbReference type="STRING" id="590646.G3B9S8"/>
    <dbReference type="GeneID" id="18247858"/>
    <dbReference type="KEGG" id="cten:18247858"/>
    <dbReference type="eggNOG" id="KOG1662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_0_0_1"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="206" mass="22144" checksum="ED569CDB863485CA" modified="2011-11-16" version="1">MIGSRVFLRSMATATKSVKPPIQLFGVDGTYANALYSASAQDSSIDKTFQALTRINELVTQDPKVSGYLTNPALSKEDRAIVIDTIASNLKLEKPIVNFLTVLSDNNRLGEFSSIYQKFGLLNDAHNGLVEAKITSAKALDSKILKRLQTAISKSSFVGEGKTLKVSNDVNPEILGGLVVEVGDRTVDLSISSKVARLNNALGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9V7</accession>
    <name>G3B9V7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHL4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_109499</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9V7"/>
    <dbReference type="STRING" id="590646.G3B9V7"/>
    <dbReference type="GeneID" id="18246119"/>
    <dbReference type="KEGG" id="cten:18246119"/>
    <dbReference type="eggNOG" id="ENOG502QVRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031572_0_0_1"/>
    <dbReference type="OrthoDB" id="6585699at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="51785" checksum="4591DC0486CA28F0" modified="2011-11-16" version="1">MSGQYRKNVLPNTYIPVHPETVFMTVLSKLPRSSLVELCSRWPRIVNTQPYSHGYSTQRACNKAVMADAVKFKQEKTNKKQIVDSIVLKYWPNGLNLLQLAQIDCQLIVDKPNSFNWISSAVKNSNGLEVPIVLEPKTFLEMLSKDLGTFFMNHIYVCKHPKLPLIIIRIQLFDLQAASSSRTSNRPHISSSRAHFVAIPMNSAYIIHTPGNDLVTDIILQVIERNLPQKKSNLLQLITDRKQQPIKSLESMQILFGNSRFGNSLGAWSAYADSTIDISPLGAIEDHTTVYKNDSKAPTETEMEKLKRIANLRFKGSEDGIIKSEQLFTEPFILQRRKKRKRPFSIYDHDNKDDSETIIHKNEFSSIAPLQYAEFELKEKLDAFADNNDNSNDAQEHYTSITLKLSGPDVFAGLHELSVMVTNEEKMVVNPVKMPSWLTGEEGQSCGIVKDGKFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA26</accession>
    <name>G3BA26_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_109573</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA26"/>
    <dbReference type="GeneID" id="18246122"/>
    <dbReference type="KEGG" id="cten:18246122"/>
    <dbReference type="eggNOG" id="KOG1385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010246_4_1_1"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="314"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="596" mass="63505" checksum="17401D8FEC21D335" modified="2011-11-16" version="1">MLSTRNVRLIVPLIALITVVALVISSSYSPISTSVQKVKEKAADAVPFSTDEEDKNTLQGKPHVGTEAPYAAGKPLSGGSSSGGSGKYKADTGLKGGVVADTSNSEKSSAQKLSLEGAGSDSALKPPKGTANKGLGNEKYGDSGSVAKGKTNGACNSRDFVVMIDAGSTGSRVHVYEFDSCVSPPALIQETFKMNKPGLSSFDTDTVGAAHSLDELLEEAVNTVPKDKQGCTPVAVKATAGLRLLGEEKAANILKEVRSHLEKDYPFAVVEGDGISMMDGADEGVYAWVTANYLLGNIGGAEKTPTAAVFDLGGGSTQIVFEPQFSSGETMADGDHNYQISFGNRDYTLYQYSHLGYGLMQGRNKVHGVVVESALKSGTKLKKYTKKDELKDQKASVTLNNACIAPGVVAENVQVELAKDEFYLVNMKGPEADSSIHAGANCRFLAEKVLNKDIECSESPCSFNGIYQPSLTKSFNALNDMYVFSYFYDTTNPLGFPSSFTVGELSELAKVVCGGEAFWGSVLLDDGVGKLNKEPQWCLDLSFITAMLHTGYDIPLHRELRTAKTINNNELGWCLGASLPLLEKSSGWKCRISEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAN0</accession>
    <name>G3BAN0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_109366</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687618.1">
        <property type="nucleotide sequence ID" value="XM_006687555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAN0"/>
    <dbReference type="STRING" id="590646.G3BAN0"/>
    <dbReference type="GeneID" id="18246104"/>
    <dbReference type="KEGG" id="cten:18246104"/>
    <dbReference type="eggNOG" id="KOG1460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="6">
        <location>
            <begin position="313"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="431" mass="48390" checksum="9B758C48D8A4ED99" modified="2011-11-16" version="1">MAYSVVILVGGETTGTRFRPLSINTPKTLFPIASKSLISRIIDKLMSHLHHSISQVFLLGFFKDSAVFENYSHKLAGKYPTVVFEYLSEANSKGTAGGLYQYRDKILTPESEGLIFVHGDVFCNYPFEMMFDQHIQQRSGVMVLGVNPLLIPDFFRKYLNIQADDPVASEKNSILSCFGTIISKKASDSVMHYVEKPSSEFCVQFDSEYDVLINGGIYMFSKDVILNLLEVAHIRKETEEVTGKGDNISLEMDILRWLPHQTYSFDVFKHQDYWYNLKTPLSALLANSAFSRNSNGWNDEADQLDLEYTNPYVTIGKNATIGRNVKIGNGVKIENAIIGDNVIIGDNSYVTNAIIDSSVVIGPWCRIEGSINNSTIWNDIKHSHSAGNIQNIHNLVVLCENTHVSEGVFVFNSIVLPHKELSCDIKYEIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAX2</accession>
    <name>G3BAX2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114938</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687645.1">
        <property type="nucleotide sequence ID" value="XM_006687582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAX2"/>
    <dbReference type="STRING" id="590646.G3BAX2"/>
    <dbReference type="GeneID" id="18247645"/>
    <dbReference type="KEGG" id="cten:18247645"/>
    <dbReference type="eggNOG" id="KOG3574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020502_2_0_1"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="546" mass="61090" checksum="520F63221A572C7F" modified="2011-11-16" version="1">MADDTTIHRRTFAIDPQFEEGDGLLPISQQDEKLFQPKKTSSSKSNSLPKIDRPAFAILVLLYLLQGVPVGLAFGSIPFILKTKLTYSQVGIFSLAAYPYSMKLLWSPIVDAMYFPKIGRRRSWIIPIQTISGLTLIYLGSQINQLIENPLDNLPKITSFFFILVFFCATQDIAVDGWALTCLSPEGLSFASTAQTIGINAGYFSSFTIFLALSSPDFANKYLRSEPLDEGLFTMGSYLRFWGCMYLLGTVVVCFVPEDPPHLAQQNQAKLANERIKLDGFVNKSNSKILGVLKSSSNVYDSMYQVLKLPNVQTFVVILLISKLGFQVNEAATNLKLLEKGLSKEDLSITVLVDFPFEMVFGYYSGRWSTGKKPLKPWLLGFAGRLFAAFLAQLVVYNFPSDGKVSTSYFLVIIVQHLLGSFMSTIQFVSLCAFHTKIADPAIGGTYMTTLNTLSNYGGTWPRLIIFYLIDKLTVSSCSLGYRIVSETIKQKCLGDGGEVQIIRDGYYYTNFLCISLGIVIWLWVRRKVEHLQALPNSAWRVSREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB23</accession>
    <name>G3BB23_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115586</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB23"/>
    <dbReference type="STRING" id="590646.G3BB23"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08254">
        <property type="entry name" value="hydroxyacyl_CoA_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="32"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="187"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="346" mass="38107" checksum="C279B1255B640EA7" modified="2011-11-16" version="1">MSAIPKTQTAYGYERGKGSVAKYENVPVKQPGDNQLLLKIEAAGLCQSDLHILKVVDEEYPANFIMGHEIAGQIVQVGKNLASDPKYQLGSRYSLCICKSCGVCKNCRKGLDMCCDEVSGYGIGTDGGFQQYIVVENLRSLVPIPEGVSYQEAAVATDSVLTPYHAIRKVQQFLEPTTRVLLFGLGGLGLNALQILRTYGCYVVAVDRKADLEAQAKRYGAAEFYTDIGDSNHPTDSFDICFDFCGYKQTFEDCQDYIARDGKLVIVGLGNLQLNYMNFYLARKEVTIYANFGGTAGEQLACLELVRLGKVKPLIKSVSIDELPYYFDQLAKGKVEGRIVFTPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBJ8</accession>
    <name>G3BBJ8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_131106</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BBJ8"/>
    <dbReference type="eggNOG" id="KOG0889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000129_1_0_1"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000044">
        <property type="entry name" value="NuA4 histone acetyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2610"/>
            <end position="3165"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3345"/>
            <end position="3682"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3680"/>
            <end position="3712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2041"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2042"/>
            <end position="2052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3712" mass="425350" checksum="A6A5BB7140C72A4B" modified="2011-11-16" version="1">MSYKSQLDTFVSRLNDNDDYKEKHSILRELLDMIETFNGAAEYEYFLSNLIPIFLNYLKEVPIVFTSQAPEQKLRNSVLEIIHRSIMNETFQPYSEQILDTLTTILVDENEDNGVLCMKIITSLHKAYKANLGEKAQGFIDVISNIYDNMPETVSNVFSSNASSTPSQDVDTKESSPTSFGEENTSKTLNNAMHSFKTLAECPITMVSLYSSYKNLVQTSLGVFLPKIVNLLNLQVEEQKNYRESPENENKVVTSISPDITNRQAYSDFILGQVKAASFLAYVFIRGYANQHLSPEQAKVVPDVILRLLQDCPAELSVARKELLHATRHILSTPFRSQFIPKIELLFDEKILIGEGLTAYETLRPLAYSTVADFIHNVRNELTPKQIWLTVSIYCDLLKDDSLALTVQIMSAKLLLNLVERIMKMPNKGEGRQLFMIIIDSYAKRFHSLDRKYDYIMRVHKEFEKNKATKEQESKKAVSRYSSKKSLGLEAPIKDIKFLKDVDSAPVEKPNDDDDIVMRDANGDLNGDDEREHDGDTKMDEDHEEIIDLFNLESLSPLNASSTVNSDMLKDARYLFRTLMTFLKSVIFGLKNCNPPIPPQPTASDPKNGGQTVNYDKWNESAKITSFEEVNILRELFRSGISCLRFFSISKPKAAPQTKAFDFSSGGPNLPITSSKEEKDLMEIFATIFIHIDPASFNEIVGAELPFLFDSMLDNAALLHLPQFFLASEITSANFSGLLISFLRSKLGELGKLDLVKSNILIRLFKLCFMSVNLFPTTNESVILPHLNHLILESLKLSTNADEPIVYSYLVRILFRSISGGRFESLYKEIMPILPVLLESLNKMITNARRPYERDIYVELCLTVPVRLSVLVPHLNYLTRPLVHALNGSQELVSQGLRTFELCVDNLTAEYFDPMIEPVTDEIMTALWKHLEPVPYHHQHSHTAIRILGKLGGRNHKHFKPYSRLQSQDALNHEVKALFSIHGLDGEIPVSITPGVESAIKLLEDQRIKLHYRVSAFKYLTSICKLLIDSTPVPEDLPSYISKCVQILKEEKVEDEIELEVSDVKDAGKLDIQQKLFSKLLEVLFFSMSVPELKEEAGKLIDGITVHFTLTYLRVSVVEKLKKERSFSVKDKEGKVYISENAFLNALNYALSFWDKEVRDKGVETIKTIHTTTVAIFGSDEDALFSPFFRTIFYRFTHCCYSEFYYTKLGGVLGLKTMVEELTIPISWFSKRQFELVRSIFFIARDTPDTAPRIVRELAEGLVLSILHDCNVDMTKETLLEKPFQTIVGALVYDLASANPHVRQLSQKSLKVLSDTTSVPIATIIGPCKQLLLTPIFGKPLRALPFPMQIGNIDAITYCLSLDESFLTFNEELNRHLFEALVLVDAEDESLANVHRLYEHRTSKQLIELRVVCIRLLSLALTRPDFSLSSAPEARIKILGVFFKALCNKSTEIINAAYLGLKSSLQGNAKLPKDLLQNGLRPMLMNLSDHKKLTVWGLEALAKLLELLIYYFRVEIGRKLLDHLMAWAQINTLRHISSQDLESNHTVKIVIAILNIFHLLPAKAFTFMEEIINTLQYLEGHLDRHLNSPFRPPVAKFLNRFSENTVEYFIKNYKNRKLGNMLAHFVGLSECSNIRELMKEKFSEITDDLESETDYEVKVIKYANTVDLLEAMSENDNEWFNEQKDLTLKLFKMSQDVLNTNENSASSAYFQSDQAISKIQRLIVRFMKQNPANVELLFLVIDEIFLSDKRVPTLVEDFIFQSIVSSEDTVFKAKYLENCTKFISKPESHLGAKIFILKKVFNSIILFEIKRSGGLDAFFKGKKSPVWLKSFCEDIWRSTNDIITSHTSGRLDRYRFQLLEATAILIKWGSHHISEYRKDIIKFSWNYIKLEDNITKQVAYVTTSYFISAYETPSKLATQVFVALLRTHQTDSRHLVKQALDILAPVMPERVEGDTSLSWLKWPRRVISEDGFNVTQVLNVYQFIVQHPDIFFVAREHFISNIITAMGKLTILANPAVENQVLAIELAELILNWEEKARLEDTSVEESDESDEDKQVSADDFTTSPNYKAPLGQKEACVTFLIRYVCISPQRASESELGQRALGILSDLLSPKHWNEVSVKLSFFEKFLLSNDLNSSNLLGYCLNALEVLGVVLEWKTSEWILKNIAYFHKLLEKCIKSDNHDIQEALQRVLRTILQAINDEQKVELSEDMDTEVKEFVDLLATTVAEDLNEMPSVAAGVTLSWTLANYMPNTLDPLLPLIMRTFSKLCKDHITITHQGSQSSSSGDSSTESEAKMTTRLLERILNLSSMRISSLGDQRRIFLSLLAQLIERSLDKDTLEKIIKIVKGWVFSHTDLFPTTKEKAAILAKMMVFEIRGEPTLSKEFYQIIVDIFEDDAFSNTELTVRMEQPFLVGTRSTDVSIRRKLMSLLNKSLEKDINKRLYYVIREQNWEYLADYPWLNQALQLLYGSFDSEKKLEVVADEYKMAPLDSFPFTVDNEMEVDSSEALTDILSKHNEFLSEISQLQAGEVLEPLIDMFYQSSESVHKAWSTVFPVAFESIARSEHLDFTRFLVVLLSKDYHTRQIDSRPNVVQSLLEGISKCKELQLPPFAVECLAANFNAWAHGIHILENIEEQSVNGNAEVREVTQDALAKLFATLKEDDMFYGLWRRRAKYSETISALSFEQIGLWDKAQQLYEAAQIKARSGALPYGESEYALWEDHWILCTEKLQHWDILTELAKHEGFSDLLLECGWRVADWNADRETLEQTVKSVMDVPTPRRQVFETFLCLQGFGQQRQTLQDLSRLCDEGIQLALRKWHGLPSKFNNAHIPLLHTFQQYVEFMEASQVYASLVSTNAQNLDVKSQDLKRVLQVWRERLPNIWDDINIWNDLITWRQHAFSVINEVYMPFIPVLQQANTGSNANSYAYRGFHEIAWVINRFAHVARKHGMAEVCISQLTKIYQLPNIEIQEAFLKLKEQVKCHYQNPNELNTGLDVISNTNLVYFATQQKAEFFTLKGMFLNKLNQKDESNKAFATSVQIDLNLPKAWAEWGAFNDRRFKENPNDMVYANNAISCYLQAAGLYKNGKTRKLLTRVLWLISLDDNSGTLTQAFENFKGEVPVWYWITFIPQLLSALSHKEAGLARQVLIRIAKSYPQALHFHLRTTKEDFAAKQRQKSWEHVDEIMGILKTAYPLLALSLESLVDQINQRFKCTADEDAYRLSVALLNDGVQYLNRLGNPRDDAKLPPVTEANITRFAETVLPKQIRTEFEKDLVVEKPNLETYIMKLRKWRDRLEDKLDRRFQEVNLENLCPHLSEFHHQKFEDIEVPGQYLLNKDNNTHFVKIDRFLSTIDLVRGTNACYKRLRIRGHDGSEHIFGIQFPAARHCRREESLFQLFRIFGDTLSRKVETRRRNISFTLPIAVPLSPHIRIINDDPADISLQKIYEDYCHRNGKNRDEPFIYTIEKLRAAFDPRLPKPEIMSIRVEILSSIQTLLVPSNVLKNYFVDNYPLFEDFWLFRKQFTSQYASFIFITYMMCVNTRQPQKIHVNRKSGNVWTSDMLPCKIASKNASLDASQGQRAAPLFYNAELVPFRLTPNIQKLIGETGLEGILSVYILAIARALTEPESDLEQYLTLFVRDEVISWSSQQDPPRPVPKDKQLREIVRVNVDIIIKRVLSVGHISSGPTVATQNVLELISQAVNPRNLAAADTLWMAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBR7</accession>
    <name>G3BBR7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115685</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBR7"/>
    <dbReference type="GeneID" id="18247965"/>
    <dbReference type="KEGG" id="cten:18247965"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007678_1_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF34">
        <property type="entry name" value="ZINC FINGER PROTEIN YGR067C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="773" mass="88185" checksum="887202AE1C25B952" modified="2011-11-16" version="1">MAVQKKYVCAFCARAFTRSEHKQRHERSHTNEKPFHCMHCTSAFVRRDLLQRHCRTVHSINLSSANFPKPVDKKPVDDGRSSSSNDDSSLSPSNSQPNPSHLTIQTVVAGEFDGSARPRSNSVASIGVASVTSATSGTKDENNDLVSLLSISKRLYQMLTQFDVDITKYTETELNEIFLIGYIELANTDRFPVLEEMLKKLLHHLNSNLSDTNNFKVVSVYTVLAVGFNVKNNMGSSMELFNKGWNLLTLKSIPMKDNNNNASNQMEILNNLFLLNYVFLEYNLDAPKQDAGHFANMNLNSDLLFNYLNDIASIILTNLLQEKDRVVVLKTHMNSFWSIYVLLSNYFVNSYPPKFYNVFLDQVVMKNQTLSQVMLDLSRTIRLIESSFVKEIITCTLINELNHLIHFNKLLIYDSKNSLHNSIILINKSVIDLSSNNKIFEIFKKKLIINCPIKFNDLLNHYIFQPSHKYEFNLLSVALKEFNYNHNYNYNFNFNLFILNNLKTDLFKFSNGLLPFFNTSVNEINNNLGIIGFPIIFNASFLNGKFGILNVHQSSDFDKRNLNLLIIEWYLTMFKILVNLQKNEALVNNYIIQCVLYLLNGNEQGFQINRADWFMDILKRLDGVYHDWLNFIDHKDYLVDFNANLNSFLNNFISSNLVDNDSNYTTLKTNLSTTSTLSNGSGLTGTQMYPALNYQMGHPIGGYKPFDSRSPDMNAGGLPQLSSVAASISNGSFKSVLLPNPEREKERELMLPPIKSPINKVTTVQPLVSDLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBW8</accession>
    <name>G3BBW8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116118</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBW8"/>
    <dbReference type="HOGENOM" id="CLU_2996356_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="57" mass="6229" checksum="1864D69005258EF8" modified="2011-11-16" version="1">MLNLGSSLKLLKRIGDRNLGINLVVFYSAESGRVRSLIPPEDSARFNVGYDCGVETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCB3</accession>
    <name>G3BCB3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-alpha-acetyltransferase 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_110993</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCB3"/>
    <dbReference type="STRING" id="590646.G3BCB3"/>
    <dbReference type="GeneID" id="18246239"/>
    <dbReference type="KEGG" id="cten:18246239"/>
    <dbReference type="eggNOG" id="KOG3139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_0_3_1"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000199">
        <property type="entry name" value="N-acetyltransferase catalytic subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="194" mass="22446" checksum="16BEC89DD059BC7B" modified="2011-11-16" version="1">MDSSGSFKDTDDYGLVATVGNLRYQRFNPASQNQFRIISNLIADHLSEPYSIYVYWYFLNTWPQYCYITKDSADTVVGVIISKINLHRNVRTRGYIGMLVIDPIYRKKGIAKKLVQLTIDAMIEADHVDEISLETEVINKGALRLYESLGFMRVKRLYKYYLSTHDAFRLILPVSDRAFKRIAFLDQLPEPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCF3</accession>
    <name>G3BCF3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_116886</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690487.1">
        <property type="nucleotide sequence ID" value="XM_006690424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCF3"/>
    <dbReference type="STRING" id="590646.G3BCF3"/>
    <dbReference type="GeneID" id="18248490"/>
    <dbReference type="KEGG" id="cten:18248490"/>
    <dbReference type="eggNOG" id="KOG3365">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099943_0_1_1"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15317" checksum="28726D65C7F737D6" modified="2011-11-16" version="1">MRFTRVLKQAEEVLIKAASGNPTGITGLYQHPNPRPALISLYNHTLSLLDTKFPKHSIYRQSVEALTRNRLKVVEENEVSEVIENKIGGGLIEEIIIQAHEELGLAHELAELKCWEELEEKPLDDQWVYFGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCR7</accession>
    <name>G3BCR7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_116921</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCR7"/>
    <dbReference type="STRING" id="590646.G3BCR7"/>
    <dbReference type="GeneID" id="18248508"/>
    <dbReference type="KEGG" id="cten:18248508"/>
    <dbReference type="eggNOG" id="KOG2906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_0_1"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="11">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="101" mass="11591" checksum="DD20241B1DFD7FA3" modified="2011-11-16" version="1">MLLLSSEDGDSNKFYCPTCPYEFKISGFQMFDKKVLPRKEVDDVLGGEGAWDNVDQTPAQCPRDSCGGDKAYFFQLQIRSADEPMTTFYKCVKCSHQWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD78</accession>
    <name>G3BD78_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_116320</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD78"/>
    <dbReference type="STRING" id="590646.G3BD78"/>
    <dbReference type="eggNOG" id="KOG4166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="78"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="274"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="481"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV61074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="673" mass="73026" checksum="FF2806D1362BA5B5" modified="2011-11-16" version="1">MLSRNFRACRRLRLRVAAAPTSFNRSITKTSHTNATMSAAAAAARPTPAPSFNQQPATDKKPEPVPELLMDDSFIGLTGGEIFHEMMLRHNVDTVFGYAGGAILPVFDAIYNSDKFKFVLPRHEQGAGHMAEGYAKASGKPGVVLVTSGPGATNVITPMADALMDGVPLVVFTGQVATTAIGTDAFQEADVVGISRSCTKWNVMVKNVAELPRRINEAFEIATSGRPGPVLVDLPKDVTASVLRDSIPINTTLPSNALSQITRKYANEFTKEAIRRAASLINRARKPVLYVGGGVLNHPDGPKLVQELSDKALIPVTTTLQGLGAFNQNDPKSLDMLGMHGNAAANTAMQSADLIIALGARFDDRVTLNVSKFAPAARKAAAEGRGGIIHFEISPKNINKVVEATEAIEGDVTANLKKILPLIDSIKSRSEWMGQVAEWKEKYPYAYLKEEPGSKIKPQTLIKEISEQSATYGREVIVTTGVGQHQMWAAQYFTWTKPRTMITSGGLGTMGFGLPAAIGAQVAKPDAIVIDIDGDASFNMTLTELSSAVQAGAPIKVVVLNNEEQGMVTQWQSLFYEHRYSHTHQTNPDFMKLADSMNVKGIRITEQADLKAGIKEFLEYNDGPVLLEVVVEKKVPVLPMVPTGKGLDEFIVYDEEVERQEKELRHQRTGGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDB3</accession>
    <name>G3BDB3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116970</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDB3"/>
    <dbReference type="STRING" id="590646.G3BDB3"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059951_0_0_1"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833549" evidence="1">
        <location>
            <begin position="19"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="306" mass="35079" checksum="8D5F7BE411BFFA90" modified="2011-11-16" version="1">MVLYKYILFIWQCLAVLAASDGFYDKNPNIYELTPATFDKVVNKSNYTTIVEFYAPWCGYCKQLKSTFQKVGKFIQNDARYSVHVAAVNCDKGYNKKLCADEKVTGFPTLKVFRPPKYDATKPTVTKHVSEVYTGQRSFKPIVDFLASRIKNYVKRVHSFEQVSTWLNKGNSTKRVLLVTEVSALSAMYKSLAVDYLGLVSFGVFTIKEQPTDAKVSIGDKEVELPLEKMGKSALLLIDTEEKSVLRYEGKLNDKLKISKWIMEKSGVQPLEGELSNKEKETYERYRLGKKIRKQKKQPELEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDH8</accession>
    <name>G3BDH8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_127423</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDH8"/>
    <dbReference type="STRING" id="590646.G3BDH8"/>
    <dbReference type="GeneID" id="18249239"/>
    <dbReference type="KEGG" id="cten:18249239"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010089_0_0_1"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="449" mass="50882" checksum="70FCF512E95FFA18" modified="2011-11-16" version="1">MINPEDYGVYPTSGFLPSKLPLEKLPQDYYKPWETIVSNLPSLILNRRVRTVINKLPLLDTTLLESFEQQRRAYQVLGFLAHGYIWGSDEPINKLPQQIAKPLLEVSEPLGLPPLATYAGLCLWNFKQIVPDESNVWDLDNLTTINTFTGGMDESWFYLISVHFEYKASFTVNTGLKILEAIEQDAPELVTKHLQTLAEMIDHLGSVLMRMEEMCDPHIFYFRIRPFLAGWRNMADAGLDKSGVIYGNDPNPKVYAGGSNAQSSSIQFLDALLNVKHFPTGQRPVPHQNTPSNTQPPSESNFMNEMREYMPRPHREFLQKIESISTISEYVTSRRDQYPELTLSYDASLAMLKSFRDKHIQIVTRYIILQAKKGSKLGSSSTMRSGLAKSRSKKKEEEQRGTGGTALLPFLKQCRDETGDPAAGNWGKRILSDGVMRLNFSRPNGINED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE53</accession>
    <name>G3BE53_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multicatalytic endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_132211</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE53"/>
    <dbReference type="STRING" id="590646.G3BE53"/>
    <dbReference type="MEROPS" id="M67.001"/>
    <dbReference type="GeneID" id="18249602"/>
    <dbReference type="KEGG" id="cten:18249602"/>
    <dbReference type="eggNOG" id="KOG1555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052991_0_1_1"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="312" mass="34882" checksum="6AD4E52DC68711A7" modified="2011-11-16" version="1">MENLQRLLGAAGGFGRAPVAASDGPAIDNAETVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDEFTIQVIDVFAMPQSGTGVSVEAVDDVFQTKMMDMLRQTGRDQMVVGWYHSHPGFGCWLSSVDVNTQQSFEQLNKRAVAVVIDPIQSVKGKVVIDAFRTIDTSTLMMGQEPRQTTSNVGHLNKPSIQALIHGLNRHYYSLNIDYHKTSYETNMLLNLHKNTWQSGLKMSNFDHQDHKNLENTEKMVKVAELYNQRVQEEKELSEEQLKTRYVGKQDPKKHLSDTAEIAIEENVTSLLTSNINSLAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE71</accession>
    <name>G3BE71_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_116524</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE71"/>
    <dbReference type="STRING" id="590646.G3BE71"/>
    <dbReference type="GeneID" id="18248343"/>
    <dbReference type="KEGG" id="cten:18248343"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_3_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="491" mass="53770" checksum="9995E4B8A24A5AC7" modified="2011-11-16" version="1">MAPHLKNPNLLQKKSFINGEWFESKSTKTFKIHDPASGEFIAELTDLLPEEIEYAIKITHESYELYKKTNPYDRSKWLRNLYNLMMENIDDLAKILTWENGKPLAEALGEIKYAASYFEWFAEEAKRIYGHTIQPANQGNKIVTLKQPIGPVALMTPFNFPSAMISRKAAPALAVGCTTISKPDYQVPLSCLALAYLADQAGFPPGAFNVILSSAQSTPVSGLQLCESPLIKKISFTGSTAVGKLLMKQSASTLKKLSFELGGNAPIIVFDDAKLDKAVTQAIGSKFRSLGQTCVCANRIYVQSGVYDEFVKKFVEKVKAFKIGHGFDEEVTHTCLINERSVAKVKGHVEDAISKGAKYALEGGELPHLGPHYYSPTVLTGVTQDMKVAKEETFGPLAAIIKFDTEKEAIGYCNDSEFGLAAYVFSENINTCWTFSEALEVGMVAVNVGVFTEAAVPFGGVKESGFGREGSLYGVDDYTVVKSIIIGDVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE74</accession>
    <name>G3BE74_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Protein URE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_116528</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE74"/>
    <dbReference type="STRING" id="590646.G3BE74"/>
    <dbReference type="GeneID" id="18248345"/>
    <dbReference type="KEGG" id="cten:18248345"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_1_1"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000034">
        <property type="entry name" value="Transcriptional regulator URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017298">
        <property type="entry name" value="Ure2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037861">
        <property type="entry name" value="Prion_URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="61"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="154"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00058785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="303" mass="34391" checksum="E4137F346CCB7F59" modified="2011-11-16" version="1">MAGNPEHMSTVSNLSAGLKNVNISEQQLRDTTILQQHLTNEVNDQTQISRISAFFQNQPTEGFTLFSHRSAPNGFKVAIILSELNLNYNTIFLDFNSGEQRAPEFVAINPNARVPALIDHYNDNTSIWESGAIVLYLVSKYLNEQGECKLWSNNLVEQSQISSWVFFQTSGHAPMIGQALHFRYFHSTPVPSAVERYTDEVRRVYGVIEMALAERREALIMDLDVDNAAAYSAGTTPLSQSRYFDYPVWLVGDRATIADLSFVPWNNVVDRVGINLKSEFPEVYKWTKYMMRRPAVIRALRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE90</accession>
    <name>G3BE90_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_127762</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE90"/>
    <dbReference type="STRING" id="590646.G3BE90"/>
    <dbReference type="eggNOG" id="KOG3166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055193_0_1_1"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="8">
        <location>
            <begin position="122"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="265" mass="28970" checksum="72F5ACFF95098F8F" modified="2011-11-16" version="1">MPPKKVAPAPLATRSAKPVKASKNPLVESSPKNFGIGQAIQPKRNLSRFVKWPEYVRLQRQKKILSLRLKVPPAIAQFSNTLDKNTATQTFKLFNKYQPETKAEKKERLTKEAAAIAEGKSAKDASPKPLNVKYGLNHVVSLVENKKAKLVLIANDVDPIELVIFLPALCRKMGVPYAIVKGKARLGTLVHKKTSSVAALTEVSAADEAELAKLVSTINNNFLEKYEENRKHWGGGILGAKAEAKRIKKAKNSDVPIPAPVAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE98</accession>
    <name>G3BE98_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_136967</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689710.1">
        <property type="nucleotide sequence ID" value="XM_006689647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE98"/>
    <dbReference type="GeneID" id="18250024"/>
    <dbReference type="KEGG" id="cten:18250024"/>
    <dbReference type="HOGENOM" id="CLU_618201_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="443" mass="49986" checksum="36D06E48E4535068" modified="2011-11-16" version="1">MEPKEIITMTSKTGKWFKNSTKNIHLKFLVTTLVSLFVVSFMNFEVFTSYQADLNTVDIIHYLSTSNKTVIDEVDFRLPGIIQDSYSRNQDFYASNYETSTIIFSPSITISKNYINIHLSEGHFNFTTNTVIRDESSMFHNVFSKTLDDSNMFVFRNQNLTQFIRAHLLPFYEGTRYLKGFEEFDKFRLLIHLSNMGVLFSSTVIMFILIIIDICYHTPRGLLVRMCASGLFCGFITSFGFQILNLVTLILMNSKFPNKKLTLSLIMVICGFLNSICLSILISRFVLHSVDFSNSVNEVSSRSNPQYPNSETSSYYPSDSSPEESGNGGRVYSGSIQVPKTRSPKTSNLTHQRSYTAPLLKSPAESDSTGFEQLKSGLYEKSSFIPSAKAKFSSVGSNGEHDIHIDPIVSENGTSSPDPVDSDKNNEDLKLRRVSANSHKEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEM0</accession>
    <name>G3BEM0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_110295</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEM0"/>
    <dbReference type="STRING" id="590646.G3BEM0"/>
    <dbReference type="GeneID" id="18246185"/>
    <dbReference type="KEGG" id="cten:18246185"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV59926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32059" checksum="6900F7938C12C3DA" modified="2011-11-16" version="1">MPNNRSVLVTGASSGIGFAVAKEFSSRGYKVIAGARRLSSMEELAQLNVKTIELDITSLESVKKLKLLIEAEYNGELMYLLNNAGQACMAPAMEVSDERAEQCLQVNLLSQIRVTRELTPYVINAKGAIGFTGSIAGITNLPFVSMYSCAKAALSSYASSLAYELEPFDVKVLHFITGSVPTGFTDSVKFETSYYDEEGLEDYFAARSDFGKKGPTPEIHAEKIVNDFESSKLGVVDYYRGGKALFVWSTKFMPRFLFSFMFVRALNLQKLFSNIRKKYSSLNPLRHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEW9</accession>
    <name>G3BEW9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_115981</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEW9"/>
    <dbReference type="STRING" id="590646.G3BEW9"/>
    <dbReference type="GeneID" id="18248107"/>
    <dbReference type="KEGG" id="cten:18248107"/>
    <dbReference type="eggNOG" id="KOG4771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078857_0_0_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV59956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="206" mass="23815" checksum="20C647FF03324A10" modified="2011-11-16" version="1">MASVRKRKMARSSVKKNTRRLKDKHARVKIFSNPLIKEKWDSSLTLQQNYKKLGLRAKLGHIAGGVDRPLQKYSDGPKDDPATVKPEDVEQTEDPAQIPEGEARIIRDPDTNEVIKVIYGTMKGNSTQNQKEDSEVVQELQKTALKNASIVKERVQSERESDWLTSLYEKYGDDYEKMKWDKKLNIYQQSAGDLKRRIIKWKKANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF09</accession>
    <name>G3BF09_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_95453</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689196.1">
        <property type="nucleotide sequence ID" value="XM_006689133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF09"/>
    <dbReference type="STRING" id="590646.G3BF09"/>
    <dbReference type="GeneID" id="18250503"/>
    <dbReference type="KEGG" id="cten:18250503"/>
    <dbReference type="eggNOG" id="ENOG502RRDG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767260_0_0_1"/>
    <dbReference type="OrthoDB" id="4095926at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV59982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="361" mass="35425" checksum="DFD4F4250062E282" modified="2011-11-16" version="1">MGFADKIQSKLGNKQELDKLDKQAGKSVGSDSFSGAAKQQYKDGNINKANAVKYADEYDTKAGKYLGKENLSGTEAGIGSKLGGTKGDGSKLDSKDATAKETYGKGSGYGDDATGYDGTTASGKGSAGYGESTGYGKSSSGYGQDSKNPGHGTAATGTAAATGFGAGGVAASKGSGGHGDSHSTTTTDPYGTNGAAGATIGTTGTTGTHGTSHGTHGASHGSTGTGTKSSGKETDWNEVGTNAKSGVTGGTNAAKSDDPATRAKYGKDAAIGGGAAAVGAAGAYGTKSHSHKSSTDSDYSSGASGTGNSRGAIGTGTGSTGFTTGNKQLDDKIAQLDPSLQQQAKDAFHRGYQDARKSFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF56</accession>
    <name>G3BF56_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_111948</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689856.1">
        <property type="nucleotide sequence ID" value="XM_006689793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF56"/>
    <dbReference type="STRING" id="590646.G3BF56"/>
    <dbReference type="GeneID" id="18246330"/>
    <dbReference type="KEGG" id="cten:18246330"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676136_0_0_1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="40"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="458" mass="49789" checksum="13C720B809534321" modified="2011-11-16" version="1">MTTAVHPPQPVPSSTTTFAGFSDATILDKFTSQPVSFTTNILVVGGAYAGLSAINAFVTHFKAKSREFPGKYSDKNMVSITLIEPRAGLLNVIGMPRCIVDTEFAQTQFVSFDRLNNFKIDRVVSANDDVVSELAPSPAETSDNNLAGVNVNYVQGHVTYLDETKAQYTLVADTGASCGQAVVDFDYVILATGRDRNWPTTPKAYTHKSFLREMDDSMVRIDAANTISIVGGGAVGIELAGDLKHFRPHKTINLIHPHASIPPEPLQEEFKRLALDSLCQSGVNVILNTRIEAPKSVDLGTTSGDLSTTSGGTITSDLNIWCTAHRNNTSLLAGHLKQFVTPKNDILVNEYLQLKCEDHIISNFFVLGDLVSLDIIKSAGWACYHGRQVANNLTSLIFDNTFVEPTPALDQVPRGMVLVAGNGELICELGGEVSKNVPDFVEEYKDYCFGRLRATLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFF1</accession>
    <name>G3BFF1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_111146</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689888.1">
        <property type="nucleotide sequence ID" value="XM_006689825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFF1"/>
    <dbReference type="GeneID" id="18246252"/>
    <dbReference type="KEGG" id="cten:18246252"/>
    <dbReference type="eggNOG" id="KOG2752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025221_1_0_1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="446" mass="50312" checksum="9437DDE824E103BE" modified="2011-11-16" version="1">MKDNESNDTGGADDKVTTAVAYIEEQDELEKEAKELMPYEPNECTFNQGPLRQPVFACLTCSRDNNGNAIGVCYSCSIQCHSSHEIVELFSKRSFVCDCGTTRMSKSFNGACKVRNKIDHSDESFRPRTGSSSTPSHRSWGSVSNLDSPAEDVPGSNSYNHNYKGLFCSCEKPYNPLEETGNMIQCYFGFECGEDWYHEDCILGYTKEALSKSKVKPEPSNLLNNLPEPGDEAANDISVNTTSEPGLERVVPHFPNLEDFDVFLCWKCVSVFSKVFDTLETHGDIVLCSLPHFKDVKSESEWEALFAQYKGNDEGEPSSKRIKLESSTSVVPKSVFFKFDFRDNLKQLKDTTTDDKIKNFLINHDYLYESDPVYEPPEDDESSSTLELGADVLSSLPREQAVEGLQAYNQIRSKLKDFFKPFAEQGKVVTEKEVRNFFSNIKKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFJ9</accession>
    <name>G3BFJ9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">ATP-dependent RNA helicase DBP5</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">ATP-dependent RNA helicase dbp5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">CANTEDRAFT_99577</name>
    </gene>
    <organism evidence="30">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFJ9"/>
    <dbReference type="STRING" id="590646.G3BFJ9"/>
    <dbReference type="GeneID" id="18250868"/>
    <dbReference type="KEGG" id="cten:18250868"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="15" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="28">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="135"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="27">
        <location>
            <begin position="314"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="23">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00039604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="EGV60036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="494" mass="54947" checksum="E428BBE3DDC5D10E" modified="2011-11-16" version="1">MSDTNKSENDAAELLSSLSLNKDDKVKTDEHKTAEEPKNLTQTLVDEPNQEAKSEESKEDSKSEEPKEETKVDSNLIQSTYEVQVKLADLQADPNSPLYSVKSFDELGLSENLLKGLYAMKFTKPSKIQEKALPLLLSEPPTNMIGQSQSGTGKTAAFSLTMLSRVDVNLKAPQCVCLSPTRELARQTLDVIETMGKFTGITTQLIVPESTKLGERIDGQILVGTPGVMVNLLKKRGVLDLKNVKVFVLDEADNMLDGQGLTDQSVRIKKMVPKTCQLVLFSATFPDQVRQFAERFVPNANTLSLKQEELNVDAIKQLYMDCKDDNQKFEMLLELYGLLTIASSIIFVARKATANQLYSKMKKEGHKISVLHSDLDNSERDRLIDDFREGRSKVLITTNVLARGIDIASVSMVVNYDLPTDKDGKPDPSTYLHRIGRTGRFGRTGVSISFVHDKKSYDTLTAIKNYFGTGIELTRVPTDDLDALEEIVKKALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFL7</accession>
    <name>G3BFL7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_111885</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFL7"/>
    <dbReference type="STRING" id="590646.G3BFL7"/>
    <dbReference type="GeneID" id="18246323"/>
    <dbReference type="KEGG" id="cten:18246323"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="318"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="393"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="463"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV60048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="751" mass="86300" checksum="7CD2014EC25CC5F7" modified="2011-11-16" version="1">MSSVKKKTSSKKAVVADKKADVSQSSEAQQYVAKDTDLRYYWGLTIVTVLAAFTRFVMIDLPPKVVFDEVHFGKFASYYLERTYFFDLHPPFAKLLIAFVGWLVGYDGKFKFENINDDYVTYNVPYVAYRSLIALQGTAIVPVMYWTMKTLGYSASACLLSSMIVCFDNAHIIDSRLILLDAMLNLAVALTMLAYAKFSTYRTQPFTRIWWIWLNLTGVALSLVISTKYVGVLTYVTIGIAVVHELWILLDYQRGLTLTEFSKHFVARFYSLIVFPFILYLFWFWVHFAVLNRSGPGDTFMSSEFQESLVESPLAKFSKPVNFYDIVTIKHKETEAFLHSHKADYPLRYEDGRISSNSQQVTAVKATEGEDSILNDVNNHWEIVPIDPKFDKGVTVFTNDIIRLKHVGTGGYMLAHDVASPLKSTNEEFTITYDEEPYSRAYNESLFRLRLAQGGSGANKNRKKLVKTKATPVRLIHVDTVVSMWTHDDEVLPEWGFGHQEVSGNKKNTDPSNAWFFDTIVNLNANDSRSTYIPKKVKPLPFLKKWFELQFLMFHHNNKLSSEHPFASQPNSWPLAVSGVSFWNDNENKKQIFFTGNVVGFWFEVCCLAVYLGLLLADQVTRRRNIHLLNKKAQSRLYNTLGFLFIGWCAHYLPFFLMNRQKFLHHYLPAHLIAALFSGGLAEFVCSNNRIQSSSPIGVNKHRFTALVFVVCAGLVWFYYFFLPISYGHISLPPEEIRKRQWLDMKLHYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFQ2</accession>
    <name>G3BFQ2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_95544</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFQ2"/>
    <dbReference type="STRING" id="590646.G3BFQ2"/>
    <dbReference type="GeneID" id="18250513"/>
    <dbReference type="KEGG" id="cten:18250513"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_6_0_1"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="227"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="563" mass="61783" checksum="40E697CB8CC7C3DF" modified="2011-11-16" version="1">MAPLILEPTSSPPLGHSENPHFKTSPAKHTAAPSHTSPTKRVHLKNMSPNVSKKTIYLNFTPKHEESRIHKRPTLKRPISHPRSHSSITRHNPSLALSPSKLTQSLRRTNSFNDNAFTTSSNTLDRFIPSRHNSVSSKLETNNVKPHPNASPSTHIKAQSSKIYQKHVAEACGLDMNSRVLQYQPLPPDRKKPVSLFSSVGSSSRSITPAIAFARAKKVPTAPERVLDAPGLIDDFYLNLLAWSSTNLLAIGLEDTVYVWNASTGSVGLLCELANKCTVSSLKWSDDGSYISIGKDDGLVEIWDIETNTKLRTLNCDSHFTRVAAQAWNQHILTSGSRIGSLYHSDVRVPSHFSAKFEDAHTAEICGIEYKSDGSQFSTGGNDNLVCIWDVRSSGTTHQPMFSKRTHKAAVKALSYCPFQNNLLATGGGSSDKTINFWNTSTGTRVNSIETESQISSLNWGFSSGTGIEVVATHGFPNNNISLFSYPTLQKTGEIHQAHGSRILSGCLSPDSLTLATVAGDENLKFWSIFNMPKSGKDKDTLADSDNADFSDEKRMEKLMNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW36</accession>
    <name>G3AW36_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112175</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683698.1">
        <property type="nucleotide sequence ID" value="XM_006683635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW36"/>
    <dbReference type="GeneID" id="18246385"/>
    <dbReference type="KEGG" id="cten:18246385"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006199_3_0_1"/>
    <dbReference type="OrthoDB" id="4022214at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442604" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="333" mass="35247" checksum="A17E87EA4A1446A0" modified="2011-11-16" version="1">MKLTSLFNTLFLVASALASDIHITKNTDTVGNSEVNYGDVTVDSGITWNLVDAEYVHFHGDFDNEGDVYVTSDSASCAVNFKISGVNTKTTNSGQIVVSSGDSFTSPVFRIGGNTFENTGKIFFGGYGKTGLPIGEITSSSFHNNGLIALYQDKRNSGLVKLGAFLGSLTNDGTVCLKNQAFSQQGRILGTGCFDIGENGNVWIKSAALSITETQNFYFSSTGGSIRVEAVSAPQTFHVSNWGGDNVIGLSLPISEFGYSEDGILTVKCGLLPFYFDIGTGYDFNKMKQVTADFGTGIGTVINGGIVYQDDAPSSSRPSICATCEDLPSAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW87</accession>
    <name>G3AW87_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_117398</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW87"/>
    <dbReference type="STRING" id="590646.G3AW87"/>
    <dbReference type="GeneID" id="18248570"/>
    <dbReference type="KEGG" id="cten:18248570"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013819_3_0_1"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="460"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="372"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="584" mass="65741" checksum="247C6057DC5ABFDF" modified="2011-11-16" version="1">MSARKLQQEIDKVNKKISEGLLVFNDTHEKLFATEITTQRDKFEADLKKEIKKLQRLRDQVKQWLGDSSIKLDKKVLHENRTKIEHAMDQFKDLEKISKIKQFSNEGLELLSKTPGGRLRGFGDSMDAKKAEACEYISEVIEKLSAQNEIVETEVHSLASQMKKAKSSNAITIQASLDEAKEMHESLTNHLQKLENVLRSLENEILKPDLIDSIRDDLDYIVESNQDEDFIDYDDFYETLNLEEADFNAFNVEQQEREEAERLENEQLENELDNDKDPEKKKEEKKEEKKPVVPAVPSVPAKKPVVVPVPAPALTSGTSYSGVIKNALGEAAVAPPVSAPAPPPLASVYESGKTMAEAVAEAAALASAPSSLAAATTTPTVTRATTSAPTNGPPGLNGQNLSKVHTAKSSTASPITSAAYTEAPEVKTFLDTIPRLLALSQARLSRPLPFKTIGTLLENSLYNCPDSFDAETPRQYTPRNVHPSSIDYPQEPMFELQSANIMKKFNDDTLFFCFYYGEGIYNLSRANAARELSRRGWVYETSSKQWFQENRKTRDWQYFDYQETWLVRHKDQSVFGEHETFHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWE7</accession>
    <name>G3AWE7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112244</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684051.1">
        <property type="nucleotide sequence ID" value="XM_006683988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWE7"/>
    <dbReference type="STRING" id="590646.G3AWE7"/>
    <dbReference type="GeneID" id="18246421"/>
    <dbReference type="KEGG" id="cten:18246421"/>
    <dbReference type="eggNOG" id="ENOG502QRUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044153_2_0_1"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="60"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="377" mass="42892" checksum="154B9CCD291BF76B" modified="2011-11-16" version="1">MTVDQPNYSGIYSGTQITLSQVELPQKHIVYGNEFPYALQFNHPGELLDDKVEFLKDLAAKGTIEELLTKHGAVLFRGAGSGASETFSKLVTGVETSRGLKPFEQIGLAGKRHLRAENVFTANEGPQTKRFYQHNEYSRYTIFPSNIHFFCQKAPMVGGDTPIAHSAEFFQKVQERYPEVIEKLSQKKLKSSQFYPSRQGKISFKGNEFYWQDEDGFGQLIEEGDSEEEKKRKAEIMVRKLTDEFEWAEDGGLTIHQYVPCIRVHPKTNRPTLFNGLVGRFGTIKDVGAAEPPHMGTDGGYYPPLVYEDGEKVDNDLMEKLWRTSIELEYNHKWQEGDLLLVDNVQVSHGRQPWSEGDRVILVSMWDNGITPEVYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWJ1</accession>
    <name>G3AWJ1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_117559</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWJ1"/>
    <dbReference type="STRING" id="590646.G3AWJ1"/>
    <dbReference type="GeneID" id="18248579"/>
    <dbReference type="KEGG" id="cten:18248579"/>
    <dbReference type="eggNOG" id="ENOG502QRPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005934_0_0_1"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="932"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1050" mass="119186" checksum="AD9812B52B05BDC5" modified="2011-11-16" version="1">MATFQNESVEHRPRKKKRIRLVCENCKKKKVRCDRGHPCEQCLKIGKGDSCKYDEEALKVNNSHSQDTLPYFDSVRRPIRFEVSDNSSKSAPHNSQINLGGVKRNSAEQESETKVIDSTRMEVELLKTRLRHIESSINTGGFFTTVLNPSHPNKVKDMNNTLLPGVSRLGMLTSPVSSTSPSEQTPAITRGGDEIDNSSLVSETLAGSEPLDPYYPNELKSSNSYGMSNGGTNDSDHLGNPYASPEDKINFYEGYSTVHVKENLRRISFGPFSWCSIMQRDRALKILWDQTMKVKESSANAAVIFNEKDDLESQTKSVLSNTDSEGSLTLNEMVFEKRLLEPEGVVDMVPYYKLIKSQVQRTKPETSTSTLPLGVTYVDEKLGNELRLIDKIQVILPKQKVVWKLLKIFFKDMYPFMPFLDENSFRTEIEKILGPEGFADRKIEHINVEKRLDLAYIGTLLILLRLSFLSLFTNQNDIDESRLKMDNLNPEDQAYHYLLLNPITINIIVIAQECLDQFNLYRQPTFPVLSLALYTRLYHTYAPEDGDGADGGGSSGMLALLIKMAVSLGCNREPDNLPNMDRVSPMNNVTRRIWHCLILQDLNLAYTFGQPISISRGTYDARVPFYRKGEECLRDVELDKFITEALFGSAALYMSARNVVHLVLNVEGATKISEVCKAVSALELVMSTEYGSLDSCLNPKPGPYQDICRILAAKFYIAVKAFNIMIFFYLFLNYEKKNPELAFFYARKILLITVGEMMPHFFEMIGNFKNDLVLNPPFEQFIHKSNIILMALIIRVNFLTQEFKENPEHHSKLELNTAYNQYFKNLIQLSSALTRCLEVSIAVISKISNRYYYAWRITKGHSFLLRTITKNKFYQENREAGAALRLGQFSNSQIEGLTNICETTLGKLGKQNTDYVCNSDICVEFKKHYEQTKKQQETSRTSTPVPETPGFFSKIPKAPKTPTTNQNSILEESRSPPAMTPRFDLDFVNSVEIDKLWLQVLSGKDIDNPNGRNPDILNPEPKFEFPSGTSRGSNVNDFFGSISFDALFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXM9</accession>
    <name>G3AXM9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_133057</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXM9"/>
    <dbReference type="STRING" id="590646.G3AXM9"/>
    <dbReference type="GeneID" id="18249665"/>
    <dbReference type="KEGG" id="cten:18249665"/>
    <dbReference type="eggNOG" id="ENOG502QQBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009030_1_0_1"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="748" mass="84572" checksum="3EEFB03EB25CBE41" modified="2011-11-16" version="1">MPGRRTFNGCWTCRSRKVKCDGQRESCARCEKAGLTCKGYDIKLSYYQSLTVSRDGQLIDSTKTPSGKPEKHTRRKMSLVQYPPESQYQTFAALNGSIDRLDTAVASGAPSYDIGPFRVYASTVQLPMASLPRVQTAPAKRRPSEPVHSQQSSVYRLQDLLNGEAGREELGGREPPLESDSYDANDAAEAPVYGAAELVAPSLMPLARLSIHAIKGPDYHINDQNIHHITYPTFFPNIDSDDWVPGVSEMEKLVRRGTGLTLAPLYVELLREFSSISAIFLKVKFAATENHPDFWTLYVKPLVDSVVLSEIASRDAEITDVSVDEVGSAGDKTRRWTRHLQQAIHGLVLSVAAFRHSTAAKFRIRHNTDIPGDIALSICLRKRALNMLNFHLDEYDDIHEAIPPFCHLKYDTQLLLAIVLQLEIDTYYNVFENLELLFSIGELVAQGPLKKCGNDVSICLVTMFEVMTTMYKSTQRINVYNYQMSESDMDRYDDLHDSYDLVRALGASRASTEPEPDDHDEPAIVGPTSSTQPLVDHTDYNDYTADVGVDPLATTLTPAQAVYAAYGVPQSLCVLLDHIVTLANHKRVFYSEKRYPRNFPKICSEFEEKLERWHVQWDLRNSTGKFKSRAHQAVWWYIQAVHAAIKIYFRRLIKSQASAAHVTEISRAVQEMQQDGAIRLRLPFWVGLMCANETNYETSKAVIAACFGEDLTYWRAQQVIIEMDKRRAHDPIIWMELVREWDIALFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXZ1</accession>
    <name>G3AXZ1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dedicator of cytokinesis protein 4 CRK binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_101594</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AXZ1"/>
    <dbReference type="GeneID" id="18245485"/>
    <dbReference type="KEGG" id="cten:18245485"/>
    <dbReference type="eggNOG" id="KOG1998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238900_0_0_1"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057500">
        <property type="entry name" value="C2_DCK1_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25338">
        <property type="entry name" value="C2_DCK_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="3">
        <location>
            <begin position="1394"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1835"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1835"/>
            <end position="1872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1900" mass="214570" checksum="9D8A0DB183CDB2A9" modified="2011-11-16" version="1">MSWEPTDTFLRGKVIKPFLPFEKHPDLINDNLQNLFPGDEVYIFETKNAKWARGYTVTRPFPHDFTITSVNLDELPTTKVKVSIFPLSFIEVLEKIPIRKAAVDKEFNNIADMDMVPTIEDSERERTYALAGAVPEANGNARKAIPQLPLQRFDVEDSLLDELKYTLNLLTAHIFALYSIGEFRLFNKLSQNYTELEEARVKLTHNLLTVDEVQSTKENVTFILDKIPKKLASKAARLNDVSYDLDNAGTDISGYKAILARQGDTGELLNFDNSLPSGIAANQVFCALQPNFPINYHYNDQEFSLAPRKNSKLIRDPPSHVLVDFKSVSGSSAYQPPGFAGTIAYLYIRNNRKRLTEAFAVHTDSVNDLIHVEKISAALFRNIPATETENTRVYLVAVLTEEIDLNLKESSNTPQVRRVKKGVAAGVADITRVFSRNKGSLTSGESHQFVIKLFGSYVNQKRNLKDTDGIANGGWGEIVDRIIAGSNHGVAVNPRAEKLTVAVKEFKHQFTTHENGDLENKNIIGSATPIARIKPIFFDPLAENYERLYLKMGKISLLNSITKDDLLTFEVSTPNNELITFAKASNQQEKRSWQFVSVFPDEVVGEIIKVNGISLKNPSKKLIKDDYIVLALFINGSLAGEGKLLYKTGNRLVEFNQKKNHIIEVTSTPHNIPMAQVEVTTEYIGKVYNSDSSIDSVFQHERYFKTGAKGMDELAASLIAFTKLGVSQLVKYFPELLGSLYNIIETASAQPSSSSVEILLENSFKAIIHLLDTIFGKQEQYCYMVDLYVHNQPSRPKVGVFLLNRLSELFSRAGSSWNAVSRSLCRVISVVIRLAITSMKDTEQTPEYFEAIKSLFRSVSFFLTIQSPSLINDQVLILEVIDYILSFNTRLNEEQTLEFVINFIDSIGIRGLGANEDVIINKKPVVAPKDHKIIVSKLLLIHRLFGTKLAKSPNTLPTLICRSVVWAMEVLLGPTDIDASRLACTVLNEVCTSIWNFYIIGKNEDEANLSYSLSKLLPTVARTFIKYNKFTRNNDYFKPRRTFTALFPSTFPFNESSIDSVVSDEVIVEILVELATVFSFIAKIAKSVSGNQGYAEILSTEIENDFFNPKLYLANDFQNEDLITLMTGARLIRQGKYFPEDKWLTLYATLAEGCLSALELVRPLLIAHHIPPIDKSEMFDRVLWGVYLKNLLKLGTIAPVSVEHLSDVPRKACMSITGDMRDRIAYLINEAWDALAWDAVEEDTIRFNLNKFGGYQVEFISSDYSILQYLMPFALQKNVQCQSVSVKVLWSIMVSEYILSDSIIDVERECLLGLHDVYNGHSYKPSIVVQESFIDRMKSTIRLDREDEAFNLIFNFIQTLQGFLLVLNDLTSVPVGAEFDDDRTFHKLNINAYLKNANKPELFHSFINQMYEENLKKNDYIQAALSLELLASTYVWNHQITVPPSFRPKFPEQTSFERKEALYKMIAQNYIKGNSLERATDTYNELLDSYNQHTYDLKSFSYVHNKLAKLYLDLESSDKLTPSFFRVAFIGAGFPSNIRGKDQIYEGLPFEHISSIHERLLRLYPGARIISDDAEAQRLKERLQTGRYLYVNTIEPISEISDKLFNTSIGVRQYARNKDLRFFTTMKRIPGSTSVFDLWTEETTFETYLSFPTLMNRSEIKTSRVVKLSPLDNAIKAIVRKNNDLVQLESLINIAFKEKADYMSLFNDLSRQLAGTVDSPVNGGVGQYRTFFNDAKYYGKDEYADNIRLLKNAFDDLTLILSRCLHLHGKLVSPSMKTNHDALVSLYIKNFKEEIQALDISTDYDNTNYNHNVAHYQPSVTGAINDKRSISASSGISNGASANGSRLTKSTSRTSSASSNSGLSGLSSDKNSTSNSFASSAYLNAPKRTALNWRNMVNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXZ5</accession>
    <name>G3AXZ5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_102142</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatidylethanolamine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXZ5"/>
    <dbReference type="STRING" id="590646.G3AXZ5"/>
    <dbReference type="MEROPS" id="I51.001"/>
    <dbReference type="GeneID" id="18245533"/>
    <dbReference type="KEGG" id="cten:18245533"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043994_3_1_1"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001858">
        <property type="entry name" value="Phosphatidylethanolamine-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01220">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="245" mass="27579" checksum="262BC120F5D73E91" modified="2011-11-16" version="1">MLKNPSFYLNSFKSYSRQASRPQFLKPSHFINFHSKMNLMTISQSLDEAYTKHGIVPEVVDPFKTQGLLTIEYSDKNKVTLGNTLKVDSTQHVPTIQFTVNSPAPEEEFEVSANDKFALVLTDPDAPSYSDKKWSEYCHWIVTDLALNINKDTDAESLSTMLDFSKGNALVPYVGPGPPEKTKKHRYVFLLYKQDPSAKLTAPADRPNWGTNVPGSGVRDWIKKHGGSAQLLAVNFFYAQNEVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY00</accession>
    <name>G3AY00_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein REV1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Reversionless protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_118331</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY00"/>
    <dbReference type="STRING" id="590646.G3AY00"/>
    <dbReference type="GeneID" id="18248633"/>
    <dbReference type="KEGG" id="cten:18248633"/>
    <dbReference type="eggNOG" id="KOG2093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003901_1_0_1"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="150"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="367"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="836"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV65736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1054" mass="119714" checksum="40D3A4EE170C44B7" modified="2011-11-16" version="1">MDDEHNNPAQYRSFLKSLNDSQLLSHVSSLSQSQTHISTERVLPDTPSISGRNDIDASTPNESKFASSDPFADSFNDILLAQENHIPPAQLGEQDSDTSEDEEVSGIGPKHEFGQYDVYFQNKHDKQQLRDEAYRDWDLKRRGLQGQVAYQEPIFRGCTIYVNGYTVPSINEIHRLVIIYGGIFLPHLANKSSATHIVCDKLTPRKQQIFKNCKVVKAKWIVDSVEVGRLLDWKKYRLFQEVSYDQQRLDLKSDTFAIHQFNTEDIIDEDEQNILEDFYEAEQLNNAEQLDDEKVQLNGSRADEDGRTLEKTSIMTAKHPDFLPHFFANSRLHHLSSWKADLRAKFLKMVYQAGTSKVNMNSTRKMILHLDFDCFFATASAQKHPNLDIQKDAIVVSHGNDTSDIASCNYVARSFGIRNGMWIRSAKDLYPNICIIDYEFDLYEKYASELYNYLLSRSGDFDTIYPVSVDEALLDITSYASECEESDLQEHIIRLCTLIKSDIERLTKCTVSVGVGRNVLLAKLALQKSKPDGILFLNENVQEFLDDIPMRSLPRVGYSIIEKFQQEIQSLSEVKVSDLRKIAKSRLINVFGPKTGQKLYDYARGVDDSSIRLDSGTSPALLGRKSVSVDVNFGIRFDTTKEVEVFMANMAKEMSKRLVNLELVGSQVTLKLARRADNAPRNPPKYLGMGHCNFFNKSSKLGVASNEWGILAAEIKALSRILNIPPKELRGVAVTVSKLEDSETFKRGKQQKLSAGSIVRSKPKREIIPVDTSDFKDPMEGATDIDWDIFNALPWSIRKELRGEMTRRGIISRDSSPSKGHKVYLQQLLPSGTGSQTRYVRVLESPKKPRSRSATASPRKSSVTPAPEPDLSYDSAVLNELPSSVRDEVINGLEQRKRQKVNPQTLKSKFVEIAERDKEVNKVIDENWVLEQNMLRPPARFLDMRTMYSDIKVIISGWIAESFNQEGPHDDDVQAFVGYLKQLLAQANLARCIRSVDYIRREVNYYDAISRASQTPGISPGLMEWRRIIKTKFEPVLHDYCNKNTIKLVAKTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY36</accession>
    <name>G3AY36_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112623</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY36"/>
    <dbReference type="STRING" id="590646.G3AY36"/>
    <dbReference type="eggNOG" id="KOG4143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085469_0_0_1"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="218" mass="24909" checksum="2184E61CCF32FAAA" modified="2011-11-16" version="1">MKYFYFIAIPLILYAALDRLFYTWLPSNYVFDHKVIGELVRETIAEYPNNNVTEIIVNLVPKLQATYGKEIINDLNWEDWVFNNAGGSMGNMFILHASISEYLIFFGTAVGINGHSGVHFADDYFTILTGNQKIGYDNQLEPTVFLPGDCNHLKRGNVFQFTMDESSYAIELAQGWIPAMLPFGFVEVVSSTLDFETFYRTVLYTGRDMIKNLLNGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY86</accession>
    <name>G3AY86_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_133210</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY86"/>
    <dbReference type="STRING" id="590646.G3AY86"/>
    <dbReference type="GeneID" id="18249678"/>
    <dbReference type="KEGG" id="cten:18249678"/>
    <dbReference type="eggNOG" id="ENOG502QT39">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036738_0_0_1"/>
    <dbReference type="OrthoDB" id="3992718at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442758" description="DNA repair protein rad9" evidence="1">
        <location>
            <begin position="23"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="46339" checksum="A71E7DFDD03FD908" modified="2011-11-16" version="1">MSFVAHLAQERHLLLWAKSVLALTLVSDDIKFVISEKSITISAVNSTNTSDGDISFERDFFDEYHVSFDGTISHGFDIEDATYSFIVSSNHLSILFKTLDTDSLIKLRVNFDNEFRMLIDITRKLIVKKYQIGYQPVKNQHDPVWKYYVSEHQRQQNILPTCHDSDIKYIRIDHKILKEFVDLVPQQTEEFKIEVKSNKISFNGFTKMILKDNQYLKQPMSITISLNLYELADTNMPPEFNQRINFKLKFFKIFINLISFISLHKLDQSEEFEIYFKAPGDPVLFTLRSTRHVCVHFVQLTNDEAGQTENLITQNPIMKSYKLEEVGRNSSKYATGALTHSTSRSTISRPNLLNPAKELTGDNGSYSDLEPEVDQFNVNFDDESEVELGATQHDEVRSIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYS4</accession>
    <name>G3AYS4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112795</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYS4"/>
    <dbReference type="STRING" id="590646.G3AYS4"/>
    <dbReference type="GeneID" id="18246677"/>
    <dbReference type="KEGG" id="cten:18246677"/>
    <dbReference type="eggNOG" id="KOG2834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017172_0_0_1"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="239"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="568" mass="63860" checksum="E82BB422F9EAE1AB" modified="2011-11-16" version="1">MILRFRSKQGTFRVSVDDNDMFSTAVNSVLAKIDCDISSLYISNRPNDKGSPAQELIDQTISSLNLKNGDMLYANYEERDSGISDVQTGTASISISNSRTTAVPTVSSTSSSVKQNELAVDKLLDSQDGLIPRSKSSMCRHGDKGMCEFCSPLPPWDKEYKEKNGIKHLSFYAYLKEINENKNNKNNATSYMSPLDNPSYKVNKNCPSGHLPYPKGICSKCQPPVITLQQQSFRMVDHVEFSDSQVLNRFIDSWRLSGTQRFGYLYGSYEPFDQVPLGIKAKVEFIYEPPQACELDGITLIPWENEEAIDALAAELNLYKVGVIFTDLTDSGLKNGSVLCKRHKDSYFLTNIEVAMAARNQLKYAYSTKYSNDRKFSSRFVTCVVSGGLNGEIEPRSYQVSVNAEALLEADIVTTSTQPSMMYINESNDTRYVPDVFYSKINEYGLEVKTNAKPAFPVDYLLVTLSDAMPKEPKPFFTSNSFVIEHRDFLGELQNLKALFNHLNNDIGDGSVLLDFHLLAYLLSTHILQEHEEKLLVQFVKERTQDAYLKLVESPGWMSLITILEQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYS8</accession>
    <name>G3AYS8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-1,2-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_112797</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYS8"/>
    <dbReference type="STRING" id="590646.G3AYS8"/>
    <dbReference type="GeneID" id="18246679"/>
    <dbReference type="KEGG" id="cten:18246679"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_0_1_1"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="406" mass="47032" checksum="7DD26568CD66866B" modified="2011-11-16" version="1">MSSSRSNARIIRFAVFALLLIVCGYILSTGSSYSTPTAKPASDAPKSDAASKDTKEVSPGSSPVKAVQQTVGAEKLVPVPGEKIKATFVSLARNSDLYGLLKSIRQVEDRFNGKFHYDWVFLNDEEFTDEFKETTSSIVSGTTKYGLIPKEQWSYPDWIDQAKAAEGREKMVEKKVIYGGSVPYRHMCRYESGFFWRHPLLDEYEYYWRVEPDINIFCDVDYDIFKFMKDNKKRYSFTITLPEYKETIPTLWDTTKEFIKNNQQYLAKDNMLEWLSSDGGETYNGCHFWSNFEVADLNFWRSDAYRAYFDHLDKAGGFFYERWGDAPVHSIAAALFLNKDEIHFFDDVGYFHVPFNNCPVDPEIRKAKRCACDPKDDFTWKDYSCTKKFHTVKNLPRMKGWENFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYT3</accession>
    <name>G3AYT3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112801</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYT3"/>
    <dbReference type="GeneID" id="18246682"/>
    <dbReference type="KEGG" id="cten:18246682"/>
    <dbReference type="eggNOG" id="KOG4138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169171_1_0_1"/>
    <dbReference type="OrthoDB" id="5586401at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="9019" checksum="6218801F33790301" modified="2011-11-16" version="1" fragment="single">MMKPSYNQNATHDDDDDNDEPDEWDKRIIATGCHDENLSLQLCHADTGDWRMCAKELEAFRKCWNKNNNDERTSTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYY5</accession>
    <name>G3AYY5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation initiation factor SU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_102161</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYY5"/>
    <dbReference type="STRING" id="590646.G3AYY5"/>
    <dbReference type="GeneID" id="18245535"/>
    <dbReference type="KEGG" id="cten:18245535"/>
    <dbReference type="eggNOG" id="KOG1770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_3_2_1"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="109" mass="12347" checksum="09C0DA3C7577EDB0" modified="2011-11-16" version="1">MSTIQNLNSFDPFADTGDSEAQATNYIHIRIQQRNGRKTLTTVQGLPSEYDLKKILKVLKKDFACNGNLVKDEDMGEVIQLQGDQRVKVAEFLISQLQIPKKNIKIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ22</accession>
    <name>G3AZ22_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112860</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684848.1">
        <property type="nucleotide sequence ID" value="XM_006684785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ22"/>
    <dbReference type="GeneID" id="18246709"/>
    <dbReference type="KEGG" id="cten:18246709"/>
    <dbReference type="eggNOG" id="ENOG502RITP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1326220_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="207" mass="24033" checksum="08D06BA84C1D8E63" modified="2011-11-16" version="1">MEEFGDIGSKLGDLISNLATQLSDTTTQVETLERLSKKLVPENELPGFLREVRTINGNGNSQSQTSVDAETQMIRNLEVQRSQLVMDIQKQEYIRQKISELVNHNSEMVYSVKEYMENKPKITKDDYTAINNRVVHYVDDFLKSNILSLHINNVEMKKNLQSVELLMEQLRKQIEQNYEILSSTEYQENLNQIIQKLNQIHHTFVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ28</accession>
    <name>G3AZ28_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_92340</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="GeneID" id="18250190"/>
    <dbReference type="KEGG" id="cten:18250190"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001750">
        <property type="entry name" value="ATP-binding cassette transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="840"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="919"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="944"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1025"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="137"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="499"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="810"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1120"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1377" mass="154360" checksum="480D22FA015105F9" modified="2011-11-16" version="1">MSGSRTSEEATISGGLVRQKRLLSFLSSKSIPPVPYEDERKPLPKPHRIKNFSFAWMIPMLRVGYIRTLQAADLFYLEPDLLVENYHQTFMDHFNRLDEAAKQKYMQQKGAVPEAYVTPVIVGVRTFFAMFKWRYRVCFVLMMGSQMATTLSALPIKKLIEFVSLKAEFPDTKINAGIGYAIGVTLLVFLSAALFNSYFYLTMFTGSQTTAILTKALLNKAFNANSRSRHNYSPAKITSMVGSDCAKIERAISELPRLVTFPAVLAATIAILAVNLGVAVLVAIGMILVLGGVMASFVKLMMKYRLLSLKSTDKRVTLIKEIINSLRVLKYYSWENPYLKAVGAARKEETHYLIMLQTLKNLSLCLALSVVPLASLGCFITVFSIAKGKTTPANIFSSVNVIGSLADIFISVPQSAGAVVDGIVSIRRILGFLSSGDYVQDEHVKFNPDGLPSDTDADQTVIKIESGEFVWEKFPEVKEEQKTDSKKSRKEKKQKKLEMKQQELEKAVKAPEIGYALQNVELNINKGDFIMIVGVVGAGKSSLLQAMAGLMKRTNGNMEVNGQLLLCGTPWVQNATIRDNIVFGQEFDEKRYEQAIYACSLNADLDILPAHDLTEVGEKGVTLSGGQKARLNLARAVYANKDIFLLDDVLSAVDSKVGGSIMEDCFLGMLKTKTKVLATHQLSFLGYADKIVMVHKDGSIDFGTMDELNATSSEFREMLTHRDRDDTSVKEADEEEAEEKEAEEEVLEEEKLGLEVKAIEIQDEWRTDGKLVEDEISKQNSVKLGVYLNLLDLGSGRIPSWVACTFHLMFLALAIFSDFFINVWLSFWTENKFKNRSEGFYIGVYALLSFMSVILLAFVFTIIVRMIIVASRRINVEAIRSILHVPMSFLDATPTGRILNRFTRDTDAIDNDLVDNARLVIYMLAYVIGIFVLNIIYLPWIAIAIPFIMVCCILVGSVYSASSRELKRLESTRRSLVLNNFSESLSGLDVIKAYRSVDRFIDNNDLFLDKTNEASFLVNGVQRWATIQMIGVSVFYVFVITMLCITRTFNISPASSGLVISYLMPIPFMLAMVIRFSAMVENDMTSFERIHEYANELPQEEAYIRNDTAPAPTWPEKGEIVFDNVSMKYREGLPKVLKNVSLRIKPNEKVGICGRTGAGKSTIISTLFRLFPLAEGSINIDGIDISHLGMNNLRSKLSIIPQESLLFEGDIRRNLDPFGESDDDTLWDALRRTGLLEPEEIEKFKGEKDQHKIPKFHLDSVVEIEGSNFSSGEKQLISFARALARGSKILVLDEATSSVDYATDARIQKAIQKEFNFCTILCIAHRLRTIINYDKILVLDKGVAMEYDTPINLFMDRNSIFRQLCDKSKITQADFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ50</accession>
    <name>G3AZ50_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_133441</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ50"/>
    <dbReference type="STRING" id="590646.G3AZ50"/>
    <dbReference type="MEROPS" id="C19.089"/>
    <dbReference type="GeneID" id="18249706"/>
    <dbReference type="KEGG" id="cten:18249706"/>
    <dbReference type="eggNOG" id="KOG0944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009884_1_0_1"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14298">
        <property type="entry name" value="UBA2_scUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033864">
        <property type="entry name" value="UBA2_scUBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="17">
        <location>
            <begin position="171"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="322"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="587"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="649"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="745"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV66009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="791" mass="88971" checksum="088C510F0BD31725" modified="2011-11-16" version="1">MSYGHLSTREASFPAAVSPGTVVYKDDCMYNFDTAENNSVGLDVCLSCYKAYSRSHVDYTKQHTRDSNHDLFLNIIKRLKPLQERERSVTGNGSVNDDGNERQAKIAKLEIKEFKEEELYDIFYSIYSSTENLSVPLNETPAKFQSLANSIISANSSNRQEEIKAWEQEILPCEHSIEVEQFPNDALDISKCSQCSLVENLWICLHCGALGCGRQQFGSTIPGNSHALKHFEDVGHPVAVKLGSLSATEKDNYDAYCYKCNDEVKVPNLVSNLQKYGIDLDSTVKTEKNLTEINLDQNMNWEFQLDGKNGEKLKPIFGSNFTGLTNLGNSCYLNSVVQALFHLQPYLLYFKNQKFPSYEKVPNPSKDLLSQLLKVHDGLVSGRYSKPGNSKGEDYQLGIKPMAFKSLVGEDHEEFKTNRQQDAFEFLTYLLDKIDKQFGFEVNESFKFLMTNKLLCGECFSGKASDELVDNLSVNVEDEVVSTDEEGNKVFKKVNMLDCIRNYCADEVIEGYRCEVCDKPTEAVKSCGFKSFPEVLILNAKRIKLENWVPVKIDVPIDIPYELDLNGFKVELDDTFKVDKSEPAKFTANEEILNNLLQMGFPEPRCIKALYTTGNSNLDDAMNWIFAHMEDEDIDVPLEIDSAPTTAVVVSDESVNNLTAMGFSAKLANKALVVNNNDANAAVEWLFNNPDDDGEIVETTTPVDLNQQRQRLAAKLEEDAETGQSGSYKIKAVVCHKGTSPHTGHYVVYIRQTVGDAEKWVLYNDEKVVECDDSSVEGIETNGYIYVFERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ84</accession>
    <name>G3AZ84_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_101686</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ84"/>
    <dbReference type="STRING" id="590646.G3AZ84"/>
    <dbReference type="GeneID" id="18245490"/>
    <dbReference type="KEGG" id="cten:18245490"/>
    <dbReference type="eggNOG" id="KOG0469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="23"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="848" mass="93842" checksum="CA74B1FD29B13E3F" modified="2011-11-16" version="1">MITNIGVVAFTIEQIRDLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQKAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYAAMEEDDVKEIKQKTVGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCIEGVCVQTETVLRQSLGERIKPVVVINKIDRALLELQVTKEDLYQSFSRTIESVNVIISTYVDPVLGDCQVYPYHGTVAFASGLHGWAFTVRQFATRYSKKFGVDRQKMMERLWGDSYFNPKTKKWTNKDKDADGKTLERAFNMFVLDPIFRLFNAIMNFKKAEIPTLLEKLEINLKGDEKELEGKALLKVVMRKFLPAAEALLEMIVIHLPSPVTAQAYRAETLYEGPADDSSCQSIKNCDPKGDLMVYISKMVPTSDKGRFYAFGRVFSGTVKSGQKVRIQGPNYQVGKKEDLFIKAVQRTVLMMGRFVEPIDDCPAGNIVGLVGIDQFLLKSGTITNNESSHNMKVMKFSVSPVVEVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGSGELHLEICLSDLQNDHAGIPLKISSPVVSYRETVEGESSMVALSKSPNKHNRIYVKAQALDEEVSVDIENGTVNPRDDFKARARILADKHGWDVTDARKIWCFGPDGNGPNLVVDQTKAVQYLNEIKDSVVAAFQWATKEGPIFGENLRSVRVNILDVTMHADAIHRGGGQIIPTMRRVTYAAMLLAEPAIQEPVFLCEIQCPENAIGGIYSVLNKKRGQVISEEQRPGTPLFTIKAYLPVNESFGFTGDLRQATGGQAFPQMIFDHWAVLGGDPTDPTSKPGAIVKGKRERAGMKPEVPGYQEYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZD1</accession>
    <name>G3AZD1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_112925</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZD1"/>
    <dbReference type="STRING" id="590646.G3AZD1"/>
    <dbReference type="GeneID" id="18246737"/>
    <dbReference type="KEGG" id="cten:18246737"/>
    <dbReference type="eggNOG" id="KOG2854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045832_1_0_1"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV66066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="344" mass="37429" checksum="DBCBFFB164EDBCC2" modified="2011-11-16" version="1">MPYDLVCLGNPLLDLQLDVDQEILTKYDLKDNDAILAEEKHLPIFDEIINNPKLILVAGGAAQNTARGAQYILPPNSVCYFGAVGDDIYKQKLVEANAQYGLTTKYMIDEHETGKCAALIYKHNRSLVTDLGAANHFKPSHFDIPENWEIVQNAKVFYIGGFHLTVSPEAIIKLGKHAAETNKPFALNLSAPFIPQFFKEPLAQSIPYADYIIGNESEAAAFAEANGLEATDVETVGKYIAKLPKVNTTTPRVVILTQGTEETVAVSYNKDSDSYDVKKFPVVLLESSKIADTNGAGDAFAAGFIASVVQGKTLAEGINVGQWAAQISLQEVGPSFPFPKQTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZP2</accession>
    <name>G3AZP2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3 15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_118077</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 15"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZP2"/>
    <dbReference type="STRING" id="590646.G3AZP2"/>
    <dbReference type="GeneID" id="18248619"/>
    <dbReference type="KEGG" id="cten:18248619"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_1_1"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="18">
        <location>
            <begin position="505"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV65636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="919" mass="103064" checksum="B0121125DBCD7405" modified="2011-11-16" version="1">MSSPIHNVDELPEDPSLRETESQSQTQHQVVPSSPLFFNSSSSQLHSDANNPGRNAPGSSQRTRAGDISSPLHYSSSSAHHNSENNRGPSSGRNIRTDRLTSEVDRIVRRHNRSDIQDTTSSPLRRRAFMDSPHGSQESTQPPPNPSSSNPNSDNLTGADDEPVRVIWGTNVSIQDCSNAFRDFLMSFKMKYRRLHDQGEVVFEDNELYYVQQLNNMRELGLTNLNLDAKNLLAYPASRKLYYQLLNYPQEVIPIMDQTTKDCMVSLVMDDNGFDNTATTSVDEIETNIYTVRPYNINQVERGMRELNPNDIDKLVSVKGLVLRATAIIPDMKVAFFKCNACDHTIAVEIDRGVISEPSKCPREVCGQSNSMSIIHNRSSFADKQVIKLQETPDLVPDGQTPHSINLCVYDDLVDSCRAGDRIEVCGIFRSLPVRSNPRMRAVKSLYKTYLDVVHVKKIDKKRLGADVSTLQQEATDKEQEVEQVRKITADEIEKIREISQRDDLYEVLARSLAPSIYEMDDVKKGVLLQLFGGANKTFKKGGRYRGDINILLCGDPSTSKSQLLQYVHRISPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISVAKAGIITTLNARTSILASANPINSRYDPNLPVTSNIDLPPPLLSRFDLVYLMLDKVDEKIDRQLARHLTDMYLEDVPDKVTNYFVLSVEFLTTYIQWAKENINPVITPESKNELVRAYVEMRKMGDDSRASEKRVTATTRQLESMIRLSEAHAKMRLSSTVDLIDVKEAVRLTKSAIKDYATDPITGRIDMDMIQTGTTSAQRRMQEDLNNEVLSLIEANNNAIRFNELAVKINEKSSVRVENTDLTDAIKRLAQEGKVIETGDSHRRTIRKAMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZP3</accession>
    <name>G3AZP3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_91948</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZP3"/>
    <dbReference type="eggNOG" id="ENOG502RQC8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1864863_0_0_1"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="137" mass="15880" checksum="2D112788859EBC8B" modified="2011-11-16" version="1">MARLIGPWLPRVCHHLTPVRHYSIAIPRRRATFTEVLRTPTTKSLFLTIVFGSCVTEVIARRKQLDTLRDSHHARMIILNDILARLQHGEHIDLQKELRLLSQVSDGMDFDVDEKLNQLFQMVEEPTKPTANKSEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZV9</accession>
    <name>G3AZV9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="8">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_102848</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZV9"/>
    <dbReference type="STRING" id="590646.G3AZV9"/>
    <dbReference type="GeneID" id="18245588"/>
    <dbReference type="KEGG" id="cten:18245588"/>
    <dbReference type="eggNOG" id="KOG2587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010734_0_0_1"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20912">
        <property type="entry name" value="RPC3_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="10">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="9">
        <location>
            <begin position="145"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="11">
        <location>
            <begin position="430"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="590" mass="67707" checksum="53A8C0D2B1A53361" modified="2011-11-16" version="1">MIAELSESAEGQSPMSNLWTMVTKNHLGSVAAVVVSTLISHGRLTAKDISKKTKFPLKTVKTSLVSLIQLNCVLYWQEGERVDYTFHEQGLLVLLHSGQIINHIRETYDHESAAIIQNLIQIGSIRVEDLVKDADVDTRYSVEIKLAKLFSDGWVKPLQKHDFNPIEDLWNQIYQATMKQLPRSATVSEIKRVAEAKEASRIKLTNLVESLPTGMFDKRDGMKVLKPQTQIAFSYARYQRHTRTNALVSLCESRIGPLTASVYSTALSLIEKSSPEVHHFLTSIDGMILDPEEMVRFETELENRLIDNKAMVFKAHDVVKHLHPQLDLGKSVLTHNFLKPETTRKRVVSFGEMERKLKKPKIKMENLESPLEQEDFADTVRSETASLVNHHLKLLSSSSAIPFIVELSPGTFTVPFHKLKQIVLEYNYDEVMKKTVGSDGLRILRCIKQMKLVDEKTVAHSVLLKDKLVRNEIYKLVQLNVIEIQEVPRSNDRAASKTFYAYRYKQHTSFNFFKNTLVYNMANILHLIDQFKGEHKVLLDKCEREDVKGHEAELLLDSELRTLKGLKFREINNMGKLHRLLAMYEIFSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B029</accession>
    <name>G3B029_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autophagy protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_119510</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGV65300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000000707">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="61"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="168" mass="19181" checksum="AC212EC69FCB31F0" modified="2011-11-16" version="1">MSWTSDVLHGLEIRDEIEKRDSIYFTAFKQLSLTAQKPKGDTGNDGITLHSLISDKDVLINKMNTLHFEIQKLEEKLVHTNKLNRQLEKETAALKGKITSLTFEIAEKNKAIETINDELLSCNIQNNILSKTADDLTEENESLVQRWMERVKLDAEKLNDANELVQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0I5</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">CANTEDRAFT_103033</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="18245601"/>
    <dbReference type="KEGG" id="cten:18245601"/>
    <dbReference type="eggNOG" id="ENOG502RR5U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4075141at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442781" evidence="2">
        <location>
            <begin position="30"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="429" mass="49874" checksum="06F7C338845D72E2" modified="2011-11-16" version="1">MLKKIDDTGSINKWIKWVVLLLVLRRNRAAQWAGFLSLNPVIKKVVTKALTKSKQSDSHTEPSINRVVVSQLSNLISSGLLFSAILDNPKIPSDYGVVYVFSNYIGELNPPSHSQILVTPKSSRYFKISYYNSPRLRQLYNHKQFLIFPLIFGQILSNYLTPTRYKLNQRYLSSSIKSRILNPIWINYSLGVNYHSLKWLGLLKSYFIHNLVFLLLFGVLTFKKRVVDHYYEFKHNVYNANSLKDLKSVVLNYVSYIFHRANSITNFIYLPNLISILLISLTAPVMRYIHGSRHRKLFFKSYIKVIGFIAGFVTLFANSMDLIPAFKYALTDYDDTTDSDNIRRISDGFFNGLSLYLLRLIVLQKWRILKENHPLFQTFKVKTWARLESLVLCVGIFKLMNLNDFLKNTNGKDYGTKQNSMIKLIDRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1A7</accession>
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        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_134230</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006685668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1A7"/>
    <dbReference type="STRING" id="590646.G3B1A7"/>
    <dbReference type="GeneID" id="18249780"/>
    <dbReference type="KEGG" id="cten:18249780"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026706_0_0_1"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBM21_dom"/>
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        <property type="entry name" value="CBM21_dom_sf"/>
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        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="85"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="271" mass="31584" checksum="FB5FBA389BDE729B" modified="2011-11-16" version="1">MLIRKKSGEILKSSLKSRPALTKNVSFNNFLDIKTFDGTQSPSSISRKNSPNQSPSDSPFNSPNPFYADPNPQYQYFIKSHNINTSATSHNPVHLKSINYYDNKLVGYFYCLNLGYEKSFQLKLTFNHWQTSILFNSNFKYTRSVGDYDEFKFEMPLNVTKDFEFVLSYKVNNQIYWDNNNRSNYKVTVSSALQHHDLDRHVFDLNYDIDYDYNTEVSEKSSTEGGYLDTEYVDSLLNKFISTDYKTILQNYCFHGEPSQSYFSLSDEISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1F8</accession>
    <name>G3B1F8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_93196</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QQWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003023_1_0_1"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="633"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="845"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1344" mass="152679" checksum="FFDA528E17CD2799" modified="2011-11-16" version="1">MSVMSLQSQHSSSRTRSLSSTTLLNQDDSYDKIDHNKLYECVLKVVILEYVNEARFKTPIVVEDIEDTNGSSTSLSMVTSPSKKRSSRVYGLNTPSDVKLSSSFYSNLERHLNLIAMKKKGLRLDEHTRRSFLRFYSELLDPKVKGDLKANKTPDYLLMKFVASSNREIIKLGSIPQSEISNVVFKQANEFVSILIGLVEKEKNRDLIVSKLNEHRDSLNPQKPKSSSSSVSLTSANVRYNKPSFKITDLDQATVTLLQDLFKFDSVKIQQDIFRVKDIVQEKALHQDIKQVLFYLEKDLGQFPPSSFVNNEVYSVWKSKEKANCESLIAKYPVPASMKLMSIPKLPLGEDFYILPRSSLARKFFVVLVKLCLELQSKERQLSEEAPLFSKQSSQLMNLCAKIWRIDYSTKAVCLFSAAHLSGMLKDSFYITKDPKDLAPVDVGHSIQILNYCKLILEDGPEKNHWPLKDQDEWVKNLTYSYNATMFSIKDYLSILFSKVTKPKFGPVLAFLGEYIESDFFFKQVLELQLPKKWEKKLSKTLLRVAETRYAELLENLPRDDTLSTIHVLDISESIVSDIQSLQKRYKNPLLGFLHVPRTVATVMTSMFAVDSKNILKHIDAYNRERGGFVSYGDSLEAYKSLCQIRDIYNQVNTTGVSFKFNLEKLFFSSLNEWVNESGEKIQSIVDQAIKNDNFKPVNIENDEKKFSTSVLDIFSLIREFLKILESLGWSNEYQLAKVYTILLKSISDGVLKYTSAMSDKIMFELNEDKQKKLLETTQSKADKRKSAGWFDEMKNVVNNIQIAGAKIEAEEPYNFRPETCVALNNLAAMSQQLAQLEDILDPELISKTVRSFEPNRQNYFTSHVFSLRLKRAENLASGGSYSSNIRPYVTLTDTVARKTIGKTRTINHTPNPEWDEEFELTMQPNTSITLSVTVWDEKLGTHSVCGRAVLQLDPKRFKHDGIPQEIFLDFDSQGRLLIEVAVESERADAIFVMGRAHRTLMRARERAIKLIVEKFSRFIRLCFSRANLKSICGNNGQIKPTEDQMHDAMIPLYDYLNSNLQVLAEFLTKDLLLLVMVAAWQVVVACADELLLPKLVTAKVFNLSNFGPRAASHNQPKPSTGGWQSAVTSAVANVTSTIGISGFGKLLTSNELETVFAWLNFLCFDFFHNDGNGPPIRDLKNEHYQSLLLLPVYYDGDIDYLKQEVERLSPAFVKSLRDRNNFDSGKIPLNNSTLELNSSQPGATEQKGRPRSLSRAGTMARNKTIMANATSKARKRAQQEELEARADPIAAQTSAEDIILRLLIIRDEKSFVSRRLEQREKLAHSIATERLARAAAEGSFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1H3</accession>
    <name>G3B1H3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">beta-glucosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_121234</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685779.1">
        <property type="nucleotide sequence ID" value="XM_006685716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1H3"/>
    <dbReference type="STRING" id="590646.G3B1H3"/>
    <dbReference type="GeneID" id="18248835"/>
    <dbReference type="KEGG" id="cten:18248835"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="12">
        <location>
            <begin position="730"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="813" mass="90520" checksum="0F26C34D0C1F48D2" modified="2011-11-16" version="1">MSIVEKVNLTTGTGWGSGSCVGNTGSVPRLGIPELCLQDGPNGVRYTDFVTNFPSGIAAASTFNKGLVYLRGKAIGKEHKQKGVHMALAPVLGPIGLKAAGGRNWESFGADPYLQGILGAATIEGIQDEGVLAIARSFVGNEQEHFRQVGEWEDNGWDRLEKSISSNIGDRAMHEIYMWPFADAIRAGVGGIMCSLNQVNNTYACENSYLLNYLLKEELGFQGFVVSDWGAQHSGVYSALAGLDMTVPGEIFDDWLSGKSFWGPLLTRSVYNNTLPQQRLDDMVTRILAPFFAIDTLKLPSDEDTPNFSSWTYHTYGQQYPYQHYGPIIQQNYHQNARTKFSDDIALNVAREAIVLLKNDGHNLPIDKDDGIRKILIAGSGAGLDARGYNCKDQRCYEGPLTSGWGSAAVNNPFVISPYEAIAKRAREREMLVEYSNDNWDFDSLDELSDLVDLAIVIVTADSGEGFIEVDDNYGDRQNFSLWNNGDEIINHVASRCSKTIVVVNSVGPVNMEKFIELENVVGVVYAGPLGQYVGQAIAEVLFGEVNPSGKLPFTIARKKSHYVPIVDSLKDSNDPQDNFDRDIYLDYRFFDKHNIKPRFEFGYGLSYTKFQLSDLKIVEINSPTEYLPYPEEYLPIYRTIEDDICDPEDALFPHDEFDPVPGFIYPYLYNENVQTLPDDDRFDYPLGYSETNTNSPPLSGGFGGNQALWEVLFSVKAKVKNIGKYKGGFASQLYIEFPSTFVSSPPKVLRGIDKVFIKKGDTATIEFNILHRDLTIWDTRSQQWIIQTGTYKIFVGSSSRRVELCGEIDIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1M0</accession>
    <name>G3B1M0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113247</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1M0"/>
    <dbReference type="STRING" id="590646.G3B1M0"/>
    <dbReference type="eggNOG" id="KOG4594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1194756_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="232" mass="24710" checksum="0812D4EFF069976C" modified="2011-11-16" version="1">MLPPNQSQIQQQLQLHQQSQSQQQAQQIAGQTPTSNPTKLSPSLSGPSPVIGNKPSPGEPAGKRGRKQSTSNQTTTPNSAPTPSHLKKEFSTPLTPTSETPNDTSNINVKRKRKGSVVGESPKKAALNKKNDIDSLKEEKDDKTDDSLNVMVPPSALSGNFHDIGQGDQMFSMDVLDSSSGDNQLFGSGSNSNGLEDIDFDFNSFLDGNNDGINTFNWGGVDAVDAIESGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1V2</accession>
    <name>G3B1V2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Increased recombination centers protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_129775</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1V2"/>
    <dbReference type="eggNOG" id="ENOG502S7BF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442739" description="Increased recombination centers protein 22" evidence="11">
        <location>
            <begin position="23"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26120" checksum="2001C75E56331F11" modified="2011-11-16" version="1">MRFFKLLTGIVSLSSMAAAAAAASDEERRDFSVNPVKFEVEYVIKERPDDTANDVVDLFNEESITLAYTATNHDESQIVILGIGGAFRDPNTNEILTNITASSVDPIVFSPGQSQKFSQVINLNLLTGSYILTPNFYVSIDDEFMIIEPRSQLATVSDLPISLFNPKLLFLELVLLASFAGLGYLGYELFGKSYFKKVSSVTKSTEKASYPSAAASTGKAYDSSWLPEGHVKKTKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B216</accession>
    <name>G3B216_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_133891</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B216"/>
    <dbReference type="STRING" id="590646.G3B216"/>
    <dbReference type="eggNOG" id="ENOG502RYTK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_927848_0_0_1"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="297" mass="35228" checksum="337EA9A57B723501" modified="2011-11-16" version="1">MRWLVVTIHRSASGVFRSSWAKSRYYATMSKISDFHEKHQLDPWPKNKEPTPQQIFGLTNHEFALSQLEFSKLLKTKYNKYLKIYHPDILGGIDVYNEKSALMTPEMKRSRFDMVQKAYEVLKDPKRRLAYGRSVTTDWSQYSANSSSFDAYRMANAHRKRYDFKNNEEFWRAGTWEDYYRMKHNRAPPTREELEKNKYKILVGVIAIMAITTTIQLILAFENSNSAQYQIHLQNLRLLKESEKLSHDEYANRFSTIRQFLLSRRANVNDINKLREMELQDAKVLTDYARKKVGELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2B0</accession>
    <name>G3B2B0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_133951</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685440.1">
        <property type="nucleotide sequence ID" value="XM_006685377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2B0"/>
    <dbReference type="STRING" id="590646.G3B2B0"/>
    <dbReference type="GeneID" id="18249752"/>
    <dbReference type="KEGG" id="cten:18249752"/>
    <dbReference type="eggNOG" id="ENOG502RQ2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823859_0_0_1"/>
    <dbReference type="OrthoDB" id="4084460at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="37434" checksum="79DDE4C052F1ECED" modified="2011-11-16" version="1">MNNWQTVSIVLACFLGIFLITVVFFLIYLGCHFSIILESKRYPFTKYEYNRPLDLESGLNSSIIATKSVHTLPTSHVTEEGDIIVRTGFVVGTASHGDLGSLSEFQDSNSFNTDSPISNQVSNFSICHTPSDLRERENTGSQAEVNSTDLGVPAGKLDRYDSFSKSLIIKDLMQGSPSEQPSEIREVSDPYSSNSISVGEVVVVVQSFKGDNAHEFSHLQEGDLLRVVRFYLKEGTGTLGKKGLHLLKITGKKHKFLWSFSPEPSYEDLTYISKDDPEFPLVHCTGIILNTFLEYDASNNTMALKMKDSNHLDTDILKDFPLKCVSLETTVVSHSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2C8</accession>
    <name>G3B2C8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_120431</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2C8"/>
    <dbReference type="STRING" id="590646.G3B2C8"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012437_3_2_1"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000372">
        <property type="entry name" value="Serine/threonine protein phosphatase 2A regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="596" mass="69173" checksum="9B1ED82160370591" modified="2011-11-16" version="1">MEPHFDEINNRPVHSDDLEEDGSPLDSFKTGVHIASHSQQAHGHHGYNLNPNILSPNRESFDIDLIMAPKRHSSSRFEPTDHEEIVKLPSFNEVLPEEQIPLFIRKIDQCNVLFDFSDPTYDIRGKEIKRATLQELIQFISSNRFTYTEEMYKHVINMYKTNLFRPIPPPANPVGDLYDPDEDESVDELSWPHMQAIYEFFLRFIESPDFAHQIAKHYIDHDFILKLLELFDSEDSRERDCLKTTLHRIYGKFLSLRSFIRKSINNVFLQFVYETERFNGIGELLEILGSIINGFALPLKDEHKIFLIRVLMPLHKVKSLSMYHPQLAYCIVQFLEKDPLLTEDVIMSLLRFWPKINSQKEVMFLNEIEDIFEVMEPSEFLKIQIPLFAQLSKCISSSHFQVSEKVLMFWSNEYFLTLITENAEVILPIIFASLYELTNATQPSVSNGVMKQKLAENPGAVTDANRNLIDPGLNINNDGINGMNDMTDDEYYDSFSNAHHDLDYNSGLPPHNSATTNWNRSIHQLVFGALKVFMDHNVILYDHCTMLYHQSLEEQRVREAARKDGWNKIEEYVSKLKQQKGSDNFTSRNGEKVAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2E7</accession>
    <name>G3B2E7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113444</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peroxisome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxin-22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2E7"/>
    <dbReference type="GeneID" id="18246960"/>
    <dbReference type="KEGG" id="cten:18246960"/>
    <dbReference type="eggNOG" id="ENOG502S5ME">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1402917_0_0_1"/>
    <dbReference type="OrthoDB" id="4014227at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11730">
        <property type="entry name" value="Peroxisome assembly protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024359">
        <property type="entry name" value="Peroxin-22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038613">
        <property type="entry name" value="Peroxin-22_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12827">
        <property type="entry name" value="Peroxin-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="177" mass="19728" checksum="220BCE33FE0A63B8" modified="2011-11-16" version="1">MSRRRNPRIFLTAVVASSLLAASYKLYDYYVSSSSNSKNLQDPKKYTKKSIALTLSHSILSSQLPLDEILLNSENVTFILPPNLSVDDLEGNFAGGEAGSSLPRALLKNYKLLNCSNFQGYFDIIKNLKPDMLLVCSDDLGIRSSLPSDLSRFAKEIVEVDQNAEDITTKLMPLFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2H8</accession>
    <name>G3B2H8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_103535</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2H8"/>
    <dbReference type="STRING" id="590646.G3B2H8"/>
    <dbReference type="GeneID" id="18245635"/>
    <dbReference type="KEGG" id="cten:18245635"/>
    <dbReference type="eggNOG" id="KOG0021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025152_2_1_1"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="212"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="277"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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            <position position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="473"/>
            <end position="474"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="486" mass="55302" checksum="4B1EA27549766FA7" modified="2011-11-16" version="1">MKSFPILNEEQTDSLVVNTLQWSLANGLVMYPPNFQQYSADNAPISLFPTPIPKSSFEDAINIQQTYNELYSNVITKDKKWLVQNIEQLSRFDKDFTGKLFDIYKTLINENGKVPQPLSLGIFRSDYMIHEADNNQIKQIEFNTVSVSFGGLSTKVNQLHNYLNKSGAYDTDYSYKYYDDAEIPISSSIDDIAKALSIGNYYYNGEVENDKTVVLFIVQPNERNSFDQRHIEYSLINNFGLKSVRLTLEEVSDKTTVNSNKLYLKQTMDEISVVYYRSGYAPTDYVSEECWKARLHLENNVAIKCPSILTQLAGAKKIQQILTNKQVLETFLPDLSETELEKVLSTFVKIYPLDDSEEGKIAKQLIKTDPGNFVLKPQREGGGNNIYKEDIPSFLEKLEEKDWGAYILMELITPPIHKNKLLRNDQIFEEDIISELGVFGTILFDESKGDIKYNETSGFLLRSKFSSSNEGGVAAGFGCVDGVYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2M9</accession>
    <name>G3B2M9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113501</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2M9"/>
    <dbReference type="STRING" id="590646.G3B2M9"/>
    <dbReference type="GeneID" id="18246992"/>
    <dbReference type="KEGG" id="cten:18246992"/>
    <dbReference type="eggNOG" id="KOG2971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048373_2_1_1"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000003">
        <property type="entry name" value="Ribosome biogenesis protein BRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="290" mass="33708" checksum="E07F0E76B1E42D72" modified="2011-11-16" version="1">MSAIYKALQSKSSREMADKEKTKHINRQRLLVISSRGITYRHRHLIQDLLQLLPHARKEPKFDSKKNLYQLNEVAELYNCNNIFFFEARKHQDLYLWVSKPPNGPTLKFHVQNLHTLDELNFTGNCLKGSRPILSFDKSFELGDHFKLMKELFIHNFGVPPNSRKSKPFVDHVITFSIVDNKVWIRNFQISETLETKETDEDINVDDLSLIEIGPRLVLTLITILEGSFGGPKIYENKEYVSPNFVRAQIKQQAAEDAKKRVQDAVDRKVKKRSQTLARDPLSNESVFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3A0</accession>
    <name>G3B3A0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TEA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_122273</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3A0"/>
    <dbReference type="STRING" id="590646.G3B3A0"/>
    <dbReference type="GeneID" id="18248891"/>
    <dbReference type="KEGG" id="cten:18248891"/>
    <dbReference type="eggNOG" id="KOG3841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022080_0_0_1"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="109"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="109"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="612" mass="69083" checksum="D78DD5547959710C" modified="2011-11-16" version="1">MIVDIALDGNGKQIYQVHESSKFVRREMPRSTKFNSSTTDLLDELDEEKTPIRKILGTISPSTLNQKKVSDDDSGEDSSVTEPESATRHGSMGNMLFPDEGDEYSGDLLDKNKDIWSDDVELAFEEVLSIIPKNGLNKIKISGRSCGRNELISDYILTKTGKYRTRKQVSSHIQVIKNLGKRLDVIKLINEGPSFKDDKEQMENTKKFEEIFSQINLNKSLGFNKAPKRQYSNSEPAHGGKKLKSKPHPLQLSTMNLMIENFYMSIYDSMLNNPIILSLHDNQEITSLKLKPNANISNRFPELISMNNLNLPILHNLVRIQLPTNFPLNYSIGQGLKTNLFIRGPAGSEEKQYSMFTIIYNYGKDFFKINENHIKLNDNYDFLNKFWKFFLDNEMNSNINTINHLTIKQILYEDDPVTKDENMAGHNTILKIPKRKIKHIFLWEFVKVNDLKDAVTTTSRLLLPDTVDDQVFPQVVTFNSNYYDPAGPSTGTTADSNPFTNPSYVSSAQTDFGAMDYKLKRENPDEDLGLNTMSLNPSMPLAMVTSSPLPPAPVPVSGPMPVPHGAGSAAHSQGLGGPMYSQPMQMPMGANFQHLDYDYQFLYGEPPYPGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3H6</accession>
    <name>G3B3H6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114213</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3H6"/>
    <dbReference type="STRING" id="590646.G3B3H6"/>
    <dbReference type="eggNOG" id="ENOG502SAYY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444221_0_0_1"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="188" mass="21130" checksum="66500442A0F67006" modified="2011-11-16" version="1" fragment="single">MKSKNDQGSPATRRKHTNSKLGCLNCKKKKIRCDESLPECNNCAKGKKNKCSYLSLSAKEVNKILLTHSLRSSQNKLLSSDYRLPTSNRGDLQGYQELEFKHELDDLPIRIPSFTYPPLQYKTVSYKDIESDFKDEEPGSGSDQNYGSAEPVPQPVDGAKGLPNAITGITRFQRVPHKIHIVPQIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3N3</accession>
    <name>G3B3N3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome-recycling factor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosome-releasing factor, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_105378</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3N3"/>
    <dbReference type="STRING" id="590646.G3B3N3"/>
    <dbReference type="GeneID" id="18245807"/>
    <dbReference type="KEGG" id="cten:18245807"/>
    <dbReference type="eggNOG" id="KOG4759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085410_0_0_1"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="7">
        <location>
            <begin position="82"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="248" mass="28096" checksum="C0DB45EE15B34731" modified="2011-11-16" version="1">MFRSFPKYLANTITRPLVVRQQPIPSLRQLHVTPVAWAKAVKKSKKDSRKTKSESDEPSATAEELIDLDEARSKFDQIIDKFNKKANEVKLGKTNPSLFDNLDVSVEDHQTSKFNTVAQASIKGRNIVITVFNPDHVQNIINSILGSGLNMNPTFDKDTGVLKVPLPPITTETKQENAKVLKAVFEKFKNNNSSSLNAVRTDYKHKLKKLNKKSDTDMKIVKEFESLHKQYLDKLTDAFKSTEKVILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Q4</accession>
    <name>G3B3Q4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_93731</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686525.1">
        <property type="nucleotide sequence ID" value="XM_006686462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Q4"/>
    <dbReference type="GeneID" id="18250319"/>
    <dbReference type="KEGG" id="cten:18250319"/>
    <dbReference type="HOGENOM" id="CLU_963104_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="289" mass="33278" checksum="F54CE803BD03CF6E" modified="2011-11-16" version="1">METAHMILSSNFGNPFNSRPSPTFAFENQVFPFADKYVICGDLNIDTCEARIESFELKLNQHVRQTIYTMAGPGYKVREVCNTTSQMVNLDYSKLEGTYKIPFFFICDMPTTKSEHFSQYYELEMILVTPRRKYNVKELVNVRKQTRPQTLSITANFHKQEFVLTTPKSFYKNQTNVVRFEYPGEVYVCVFVVERISVSVTNGENYSVSARKKVYDGTKREVSIPGKVLKQMSSGYVSKLACCEHQLEVKVSVSGKIWTVKLSIDVEAEKPASFPPTYTDIEELPRYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B437</accession>
    <name>G3B437_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_105168</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B437"/>
    <dbReference type="STRING" id="590646.G3B437"/>
    <dbReference type="eggNOG" id="ENOG502SBXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145518_2_1_1"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="54" mass="6194" checksum="ABB51210A87F0BC4" modified="2011-11-16" version="1">MSGNPWAKRDAWRYEGQFSRFNRFKGAFPGFGIGLAAFVVYVGYEKLTAKPHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4C8</accession>
    <name>G3B4C8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_93460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4C8"/>
    <dbReference type="STRING" id="590646.G3B4C8"/>
    <dbReference type="GeneID" id="18250294"/>
    <dbReference type="KEGG" id="cten:18250294"/>
    <dbReference type="eggNOG" id="ENOG502RBAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024993_0_0_1"/>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="407"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="503" mass="55873" checksum="473D85C60BD2FAF0" modified="2011-11-16" version="1">MTSIIIPQQKSIIDLIDEELYTVPNSPILNHSSPVYNPLFSGSSNYFQTSSRDTSSAYAATVAAATAAFTTAQLQAPTPLSAPLPVAVGSSSATSPSSAMTPQTPGLFNFNNLNKPQNNQKIFNDYSDPEHSFIQPNRLMRAPVESANPQSPQTQQNITASVNPFKARSRAKSMKIKTLSPPPAGKFDDLFDPNSKPSSSFNFDFENDNDSIFVHHHTNNSSNRLNEPLKNLGSDEITTTIDFNDYNDYEFDELDDMSDYESDDDNLFDYYDENDIYNGNVMGNDDSTPLVSNEMNGFNDGLLGDYTLKPSFNNDDDSLSMGVKLTDLNDQIDLEEMDTDLNDLNDSLTQENVIDDDAQDDDDDSMDIDIGLDEVHSQSSDSSFDKHDADGLSEKKTKKKYDEILDHHCNLINPNTGVPCNKQFSRPYDLIRHQETIHAAKKKIFRCVICEGRYNGGKGNGKSKTFSRGDALSRHIKVKHQLVGQEALELINDAKENAEFVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4E8</accession>
    <name>G3B4E8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_105331</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4E8"/>
    <dbReference type="GeneID" id="18245801"/>
    <dbReference type="KEGG" id="cten:18245801"/>
    <dbReference type="eggNOG" id="ENOG502RPN3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030508_0_2_1"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41748" checksum="B524331EF7F1B7C4" modified="2011-11-16" version="1">MKANKIGDIDHEDSFGHNPKNKQGYGRLGVPTPSQYGKSLPKTVTKPVVIYAVVNDDFSKIKIKPLSFRIYSHNVKNGGHDILVPGEEVWGDRYRKITNSIRFNARSNTIVTLQEVYKFQILDIMDELNRFSSKDAPEWAYYAKGRIDGEDTGEFVPILYRPSEWEAVFEDTIWLNDKNERMSLEGWDAKYLRILTFATFKHKQTGNYINVFNTHLDHVGEMARAGSAEVIVQKIQEINKWPSFLCGDLNNEPKGEPYNILTKHLINSAKHTTPFNHFGHVKSTVTGFEGEVLSAGGQNIDYIFAPSYTKKVTHNVNCADTDKYSKDPADKLLLRLDQFGMLHSKYNGVYMSDHRPLVADFSLSGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Q2</accession>
    <name>G3B4Q2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113872</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686158.1">
        <property type="nucleotide sequence ID" value="XM_006686095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Q2"/>
    <dbReference type="STRING" id="590646.G3B4Q2"/>
    <dbReference type="GeneID" id="18247155"/>
    <dbReference type="KEGG" id="cten:18247155"/>
    <dbReference type="eggNOG" id="ENOG502S4CU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097653_0_0_1"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="180" mass="19914" checksum="8224DE5D45F88C13" modified="2011-11-16" version="1">MSDPTETSGASHSEQILEASRRNNTELLLQIKSDLNNDQMKLSQLINSTKEIITNNTPLHLACHLGNWEFIDIVLDIEGVEIDPKNRAGETPLHLAVKYANDEPDHGYYVVDNLLDAGSDPRILDSYKLKPINYVKDNANLTELLEGAEYAISMEGQGLQETQEGDDGEESDGPSDSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4T1</accession>
    <name>G3B4T1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="15">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_113887</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="15"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4T1"/>
    <dbReference type="STRING" id="590646.G3B4T1"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_1_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="4 14 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="46"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV63865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="295" mass="32695" checksum="4CF29C2C73000D75" modified="2011-11-16" version="1">MLSRSLFHNKQVFLPLVTGTIGAFAAYQYYSTLITNDTGKTFTDPNDWVDLRLKSSANVGSSSKRLVFQLNEQTDVSGLVTASCLLTKFVTAKGSNVIRPYTPISDNDTKGVIEFIIKKYDGGKMSSHIHDLKPGETLSFKGPIIKWKWEPNQYKSIFLIGGGTGIAPLYQLIHEIAKNPEDKTKVNLYYGSVDSNDVLLRTELDQIVAEHKDQITVEYFLDKAPPNWSGRTGFIDKDFLSEKLPAPSKDSKVFICGPPGLYKAISGPKTSPTDQGEVTGILADLGYTKEHVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4U1</accession>
    <name>G3B4U1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_113895</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4U1"/>
    <dbReference type="STRING" id="590646.G3B4U1"/>
    <dbReference type="eggNOG" id="KOG3234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="197" mass="22850" checksum="2915C77B9FC3E301" modified="2011-11-16" version="1">MTSYKPFQLEDLYDINSINLDPLTENYPLDFYSEYLIKWPSLFFKSVEISDNSTFGDTSEISGYMIAKNEGKLSKLEWHTHISAVTIHNQYRRVGLASDLCIFLENIVNKDPDNTLFIDLFVRVTNTLALQLYEKLGYSIYRRVVGYYGRNLPQDTKHLDDEIDGYDMRKSLPADVNDETIRLNGHKVCVLPQDVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B595</accession>
    <name>G3B595_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_135000</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B595"/>
    <dbReference type="HOGENOM" id="CLU_1547337_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="173" mass="19794" checksum="42E7C17B4BF2CDD8" modified="2011-11-16" version="1">MNCSHKRSNSVDHTYRSSITSNLSLGHRTGSSSVTPPESPTFNCKTTPMKQAYFPLEIDLDEVTKHSQKLEARLAQQSAGKSDLYWKPDTVHMNLSEIAPWHSKGVQNKDGLHLNRTVSPTTRLQSGIEERPERFQLPQLSETLIQKYQTQDLKQTKSSRFLRRLSKKLENMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5T6</accession>
    <name>G3B5T6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114597</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5T6"/>
    <dbReference type="STRING" id="590646.G3B5T6"/>
    <dbReference type="GeneID" id="18247497"/>
    <dbReference type="KEGG" id="cten:18247497"/>
    <dbReference type="eggNOG" id="KOG0903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002446_2_0_1"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021601">
        <property type="entry name" value="Phosphatidylino_kinase_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11522">
        <property type="entry name" value="Pik1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="8">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="650"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="948" mass="107611" checksum="6F31CBBAA6A501F3" modified="2011-11-16" version="1">MAEEENRPLLELINSKDFDIPQCLKYLRIHTKTIGIHHFLISKLSTYSYEEIEFYIPQFIQLLVSFETNSMALEDFLLDFSSLFPHFSLIVFWNLQAYVFELRNDPESYSFQTVRRFINQLQNIMFNSDLPVKNPHEFRENLHPGLVTIGSIAASFALPNSTYYTLPVIKSQSKQQKAFVFHLANFQKALTKNLTLKNSRISSESIDDASLKLPQKPASISSPKVSQTFGYSSERNSMVLTGEDGIISSDDEERMSSDSIRPSNYTGSKTLNEIEEALKINTTIKSKKSTGQLSRHRSLELIQSPKPNTLSQSLPDLRESQGSPVRPYISPAESETSLNLPHYNSVNSKESILPNYSSASFHSQQRMLFANYARKETDFIMSLQNVSFRLSQIPKEARLSALRAELSMINDTILPAEIDIPQLLPLTSNRNKKYHKILKLNVNEACVLNSAERVPFLLLIEYLSDEFDFDPSSEANLRIINSQLSRSSFEKSTSVTKRDIGPYSAVNLENDEGDPSSDTTGSMVNEETDLGDLKDLNNWKSEQDLNKLKLLEGQNIRNEELRGSSPQLTDVPSKVLANQMRIASVMLQQLEDAGKENTEQSASIRNRIIQSMISLQDQFEAINYEKLNELKGDDPDAGERKMENDFKLGEDWLKKKMRIKKASVYGHLKNWDLCSVIAKNGDDLPQEAFACQLITIVSNIWKAEEVPAWTKKMRILITSANTGLVETINNAMSIHSIKKSLTEHSIAGGDNSKGRIFSLSDYFEKLFGPTSLSKYKKSQENFARSLASYSILSYIFQIKDRHNGNIMVDNEGHIIHIDFGFILSNSPGSLNFEAAPFKFTQEYVDLLGGFDSVYYALFQEVCKKCFKAVRKHSEQIIDIVELMQKDSTLPCFKNGENTSVLLKQRLQLQLSDDQVDSFVEISLISKSLGSMYTRLYDQYQMVTQGIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5V1</accession>
    <name>G3B5V1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-terminal acetyltransferase A, auxiliary subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_106172</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5V1"/>
    <dbReference type="STRING" id="590646.G3B5V1"/>
    <dbReference type="GeneID" id="18245867"/>
    <dbReference type="KEGG" id="cten:18245867"/>
    <dbReference type="eggNOG" id="KOG1156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006686_1_1_1"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="88956" checksum="49D6BEFFA4475811" modified="2011-11-16" version="1">MASKRAPILGNKEDTNFNEALKLYDSKQYKKALKLVDANLKKNSSHAASLTLKGCINYYIGNKPEAESYIVKGLTKGENNYIVNHLAGIYYRAVENYTDAAKWLKAAIDNGSPNKQILRDLSNLQVHIRDYKSLVSSRQGYLEFQPGYRANWTGTAIALHLNKNYKGAISTLTKIESIIKEHLQDQDMYEQSECLLYKNDIIFQSGDVQKALETLEDDKPFIKDMLSFLEYKAKYLMVLGRTQESSIVYRQLIQRNPDNIEYYKQLEICLNIFEKPLSSRIKLYENLNKFYPKADPPKYLPMMFIPSSHPAFKEKAQNYILGQLKKGVPASFVNIKPILKNPKKLKIIEEIVASFFENALSNYDPTIKVWGLYFLSQLSLYQKDLATATKYIDTALEHSPTLVELYILKARILKHYKKYEAAAQIMDEGRQLDLQDRFVNSKATKYYLRANEIDKAVDLISLFTKLDKDAVNGCKDLHTMQANWFITESAEAYKRLYHQYEEELASIEKTPENEEIIGSLHDKIETYKGLALKRYTAVVKIFDIFFNDQFDFHFYCLRRGTPRDYIKTLQWEDTIHSTPIYVRVIKGLSEIYLEIYKEQQQKKAVEGEDDGTTVIKKNNKKNKKAKAQSLKKKESLIAKVESEKDDADPLGTKLLSDLVNNAHGNIIDNLLKLSQPLLNEAKDYQFNWELSFKLNLIKSKYVLSLQAIKNLNSILSLRGRITSKIPQIEQLVTELGEAVSKDESVNEAIKKVVKMGLSASLSDYKEAYEPYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Z3</accession>
    <name>G3B5Z3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 21">ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CANTEDRAFT_114636</name>
    </gene>
    <organism evidence="27">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10573</strain>
            <strain evidence="27">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Z3"/>
    <dbReference type="STRING" id="590646.G3B5Z3"/>
    <dbReference type="GeneID" id="18247519"/>
    <dbReference type="KEGG" id="cten:18247519"/>
    <dbReference type="eggNOG" id="KOG0419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 23" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="25">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="22">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00080892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EGV63642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="173" mass="19753" checksum="E9BF662FA631D296" modified="2011-11-16" version="1">MSTPAKRRLMRDFKRMQQDAPSGVSASPLPDNVMTWNAVIIGPADTPFEDGTFKLVMQFDEQYPNKPPTVKFISEMFHPNVYASGELCLDILQNRWSPTYDVSSILTSIQSLLNDPNISSPANAEAANLYKEHRSQYIKRVRETVENSWNDDDDDDEEDDEDEDEDEDDANDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B632</accession>
    <name>G3B632_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase</fullName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_123548</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B632"/>
    <dbReference type="eggNOG" id="KOG0968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_3_1_1"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="61"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="17">
        <location>
            <begin position="629"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="16">
        <location>
            <begin position="862"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="18">
        <location>
            <begin position="1356"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV63367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1457" mass="168345" checksum="D234AAE2018DECD9" modified="2011-11-16" version="1">MKHDSIRIQVNNYDSYQSLPSCLDSLELQVAQVPVIRVYGALVFIHNSVKYGYNALLHIHNVYPYVYVSCDYEFVKSLPEITHLGHVTSYLEAFMAASAWQKKKQPEEEDEQQSNELDITQLKSGKRRFIAKVSLCKGVPIYGYRVGYRLFYKINFLSPLYKARFTNLFNGKQVDMKQFSKSKFKFEIYESHIPYLSQFLSDYNLFSCNWLNFKNCYYRYPVISVNSYMDSKQLSILKQYLSKRIRNNVLHTRFERVGKSVLELDIKSSHILNRDSLVEQQYNMDFSQFNREPKNIGLSSVDLLIKEIKFQADICGVSFDFNSDIMGTNVDDSTTIWPNDVQLRELLDYSITLTGKIKNKNFKDYDNAYFRSFNHILEKYPTAFKLVDVEKSYMNSNVLVNDLYMYNDINELFIAQDSSFHEDISFVGSTLKDSDSDFTLSDIAESAINDSQMFLELTQQQGHTQTPLTNEGQEPTLSTRDVLREFGELGVVKINYDTPYYDDYRDTPEKPLVFSNKKIKVPVKELNTLPNLSLDSTEFSSLVKQQVGHSSMKLQSWEYYSQPPSKRAIIQSYEHEALESNKRSKFVSQLEAGGSKSNDFKFSSNDTIDKRPDDFVELTNFLMEVHVNTSSTKLPNPQTDEISVIFYKFIDSNAMVPSPILKSGILINKKSFPDISKLNLVGLRRILGDIQFLIFDNESSAVSKLLEVVEYFDPDILSGFEINSMSWGYLVERFQKKLNISLLSQLSRSKINNTGKFGDRWGYTHTSNIRIVGRYTLNVWRVLRKDLALNNYTFENCCYNIYHQTLPKIENQRLSSFLKGEFKEQLFGFSYYVNKLNIVEYFISSLDIIDKNVELSRLVGIDFNSNFYRGSQFKVESILSRLAKAENFLLNSPSKEHVHQMKPLEQIPLIMEPNSGFYKSPLLVLDFQSLYPSIVIAYNLCYSTFLCRLHGFKPSKNPIGYLNHMNLSPMIIDLLHKNDCLTVTSNGLVFVKSKIRKSILAKMLQEILTLRINIKSFLQLINQDENPQMVKVFNSRQTALKLIANVTYGYASASFSGRMPNSDVADAIVATGREILTASIDIIEKSEFGCKVVYGDTDSLFVYLPGKSRDDAFEIGETLAKTVSAAFPNPVKLKFEKVYHPSILLSKKRYVGYSYELKDQLKPKFDAKGIETIRRDGIPAQQKIVERALKILFDTSNLSSVKKYVSEEFRKILSNKVIIKDFCFSKEVRYGTYKNEAYLPPGAIVARRNIENDERSEPQYRERIPYIVYRDPTKQRLKDRCVSPEEFIERLNTSEPMQLDYEYYILKVLIPPLERVFNLMGVDLQQWYKELSKPDNDIQSTSSGITNSVFIQKKSCINCQRRIIVKNSKLCHVCLKDTPSLILSSKLEQKYLQTKLSDLNKVCGICVSHENVKATNQVFYDNCKNKDCSTYFNRIKTMNELKISTQRSDELFEVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6W6</accession>
    <name>G3B6W6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_93810</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686831.1">
        <property type="nucleotide sequence ID" value="XM_006686768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6W6"/>
    <dbReference type="STRING" id="590646.G3B6W6"/>
    <dbReference type="GeneID" id="18250330"/>
    <dbReference type="KEGG" id="cten:18250330"/>
    <dbReference type="eggNOG" id="ENOG502RXRH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539670_0_0_1"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="304"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="505" mass="57046" checksum="300BE3D5E5DE7D8D" modified="2011-11-16" version="1">MFDLSSDIIIPNFDMLDNNSGDYYYNYNEMETNYEMTFDDYDTPGGQVMTASSNLMTSNYNQQIPQYTNVSATPSMVSTTNNSVDGFTFNNYANPNLNSENLNLNNQSKPEPAHYGSQNNLNHLSVNVNLSTLNNETNFSTPNLTPQIQSPNHMMYPAAYDLVGNSYHEYAPQSHHQPPLSAQSSVPYDFHRFPSPLHAGPESQLTQYQLQQHQHQHSPVPASASAPSRTTVMPMAHSPSSTSSATAKERKNPENKIITSKNNDYRVVRGIAAGGSHVRPPKSTGDSDSTFVPIELNLMGGSAEEICHPAWSSSEKEDRRRIVRIERIQKGPKIIANFSIVGSANENPTVLPPPPNFNVDVIEVSCLECTKKLRKEEEEEEDDHDDFGSANDTEFDYYITSVEVIEIVELLIRTMSSVPSERRKERGRVRSNLVPFWAKKPISSRIDGNVQPDYRVELAKRIMGYEIRKPRGFDKEVRILRWDKLMPALRRALQCYYCEIPHKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B718</accession>
    <name>G3B718_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114385</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686869.1">
        <property type="nucleotide sequence ID" value="XM_006686806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B718"/>
    <dbReference type="STRING" id="590646.G3B718"/>
    <dbReference type="GeneID" id="18247400"/>
    <dbReference type="KEGG" id="cten:18247400"/>
    <dbReference type="eggNOG" id="KOG1617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_0_2_1"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="267" mass="29552" checksum="32FF21EF3570529D" modified="2011-11-16" version="1">MMLTNGIVYRTLIGAPVRSRVLLPRASLLGSRCDAFRPLKTSARLLNLKPNVETEPKPLKIIDNIYTIPNFLTMTRIATAPVIGYCIYTGYMNTAISLFTYSCVTDFLDGFIARKFNMKSILGTILDPIADKLLMGICTISLSVVSIMPGYMGALIIGKDAMLALMGVYYRYVTLPAPKTFKRFANLSIPTVSVEPNLLSKINTGLQMVYVGNLVFKPQIEQWIMSDYYGALLGNFEVLVAATTLISALSYIFSKRSIKTLGDKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B737</accession>
    <name>G3B737_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114400</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686883.1">
        <property type="nucleotide sequence ID" value="XM_006686820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B737"/>
    <dbReference type="GeneID" id="18247407"/>
    <dbReference type="KEGG" id="cten:18247407"/>
    <dbReference type="HOGENOM" id="CLU_2739778_0_0_1"/>
    <dbReference type="OrthoDB" id="4096107at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="71" mass="7996" checksum="8776061438491ECD" modified="2011-11-16" version="1">MLRRAATTIKLTPEDIVEYDEAVSAGLQGNSYLKEENLQEQEPDISISNYKDRNERMGVQTTQQHDQGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7G1</accession>
    <name>G3B7G1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_115727</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7G1"/>
    <dbReference type="STRING" id="590646.G3B7G1"/>
    <dbReference type="GeneID" id="18247988"/>
    <dbReference type="KEGG" id="cten:18247988"/>
    <dbReference type="eggNOG" id="KOG4149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184878_0_0_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="13">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV62269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="234" mass="25233" checksum="2875100A52D2059D" modified="2011-11-16" version="1">MIRTFVASTARSSRATISAARSSTIVRATRFHSSSPSQKLASSLINNQTWMGATMGISTIIGYSLYASIDNDVQPEDSTAISEQPAADADKEPTAEDYEGAAYNPITGEINWDCPCLGGMAHGPCGEEFKEAFACFVYSETEPKGIDCIKKFEGMRTCFRRYPEHYKEQLMDEEEMEADARGAESDVQLEPVEVSETVSVEVSENTEAPAIDALATDATATDAPATEAAGTESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7I8</accession>
    <name>G3B7I8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_109705</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7I8"/>
    <dbReference type="GeneID" id="18246133"/>
    <dbReference type="KEGG" id="cten:18246133"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="62"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="578" mass="64385" checksum="A9AC5526A1C66B7F" modified="2011-11-16" version="1">MLDDKKDQFVVDIEHDAAGSFNNSSEKTVSEDVLETTQFKDFNDKLDSAKYGQTKRRLSSRHVALMIIGQSIGTGLFVGLSSPLVTSGSLSLFTGFLFYSCFVIWPMMQAVAEMCSYLPIKGSFLHYSARWVDPALGFACTIIYLYTSIMFLALEATAFAGVCSFWSDVNAGVWITVALVSTLIFNVFGVNWYGEIEFVASITKVLLVVGLMFFSLISMCGGNPKGDAYGFGNWSKGGLVKEYLVSGTTGRFLGWWNVMVYAAFSCGGPDLLGMIASEVERPRKTIPMAGRRAYIRIYIFYLGGLFFMNCLCASTNPTLLDARANGNSGAAASPWVIGIKEVGVHGLDSLVNVVIALSAWSCGNGFTYGATRTAYSASLAGYLPRFFSKCLKSGCPIYCVIGCMAISCIAYLSIGTSTAVVFNWFINLSTTGILSTYVCIWICYFKFKRAFVAQGYDYETDSTFKPPRFVHPYMTYFGFFMTLVILLFNGFWIFFPGQWSAANFFTSYFAPILFVGLFVFWKVFKRTHWRTDLEADLTTGKARIDKEEAIEEEEYAAKPRKSGFLWKCYYKFADICYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7N1</accession>
    <name>G3B7N1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_94539</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7N1"/>
    <dbReference type="STRING" id="590646.G3B7N1"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645564_0_0_1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="425" mass="45213" checksum="8EEE4DE38CFD78CB" modified="2011-11-16" version="1">MSTFTFKWPKGPQEVILTGTFDNWSKSLHLVKQSDGSFSLEVPFPADSEKVLFKYVVDGDWVVSSHDKSEKDASGNENNYLSGEDLVSVKSAGAAVPLAGGLTAAVVSKEAKATVMPKEEQKTSLGEPGIVIPQDAEQLKVFETVRDVDAKALNEPELSAEEKKKQKKKVKRTKQKAKKKKAAKVIGTAGAAGAGAAGSEGVSGTTEESEESPEPEAKEVKVEEPAAEPVAAEEPAAEPVVEEPVAAEEVAEPVVAEPVVAEPVVAEPVVEAPVVAAVEEKTVEPVAEAPVEEKATEAVEAPVEPVAATSSADPAYHSLDPLADGKEIDAAPVKDEDEEIVIAQGKGKDIEAQILAQETGDVTIEEIQPTDSERAKLTEEANISQKSDKSVVAKKEVKKEVKKEVKKEEPKKKRGFVSRLKKIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Q0</accession>
    <name>G3B7Q0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase 1 alpha subcomplex 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115754</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Q0"/>
    <dbReference type="STRING" id="590646.G3B7Q0"/>
    <dbReference type="GeneID" id="18248001"/>
    <dbReference type="KEGG" id="cten:18248001"/>
    <dbReference type="eggNOG" id="KOG2865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_4_1"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="394" mass="44127" checksum="1C8C9E972F37BBB8" modified="2011-11-16" version="1">MLRLSNSRLQSKVVNVSPVVALTCTRSLYTPVLEQDINITRTGKVNVSVGPGGRSSRTGYVATVFGASGFLGRYVTSKLAKHGTVVVVPFRNEMKKRFLKVTGDLGVVNFVEWDPRNIKSIQESVAHSDIVFNCVGADYHTKNFSMADVNIGITERIAQAVKEAGNPRFIHVSSYNANPNSKSVFYATKGVGEQIVRDLVPDATIVRPSPTYGREDNLLNYLGPKLKMWTPNRNAKEVHPVHVLDVARALEKIGYDDSTVGKTFELYGPEKYSFREIREMIHGITQDFSQVGPFSYKFADYQIPLPLAKLAADIKQLPYWRLTNSDQVQRHVINQVIDANASTFKDLGIEDTTKLPEVLFTYVKHWRHPLIAQEGASSSSAKELKRLREIQHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B887</accession>
    <name>G3B887_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94601</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688800.1">
        <property type="nucleotide sequence ID" value="XM_006688737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B887"/>
    <dbReference type="STRING" id="590646.G3B887"/>
    <dbReference type="GeneID" id="18250418"/>
    <dbReference type="KEGG" id="cten:18250418"/>
    <dbReference type="eggNOG" id="ENOG502QQRF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_0_0_1"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF3">
        <property type="entry name" value="NODB HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="81"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="38408" checksum="10F816D1C76EFB9A" modified="2011-11-16" version="1">MDTLDFVPEALPDFELPRDLLGFGEDSLDPEWPNGARIAVSFILNYEEGGEHNILHGDDRSEAYLWEKGGVATERINGRHLMSESEFEYGSRVGAWRVLRLMKEFGFPMTIYAVAQAFSKNRAFAKACVRDGHEVSNHGLRWISWEKCSDDEQVEMIKKAILLLEEASGEAPVGAYIGRGNIKTPALTARAHAELGKPFLWQSDCYNDDVPYWVDLPQEKDLPDSEKKGMLMIPYCYVTNDYKFVASDPGPGFPGAFVYEDYLKQEFDQLYREGGKVMNIPMHSRMVGKPGRINALRNFIKYISEKEGVWVCNRRDIASHFREKFPYVPGKLAVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8C0</accession>
    <name>G3B8C0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin cortical patch</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_124794</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8C0"/>
    <dbReference type="STRING" id="590646.G3B8C0"/>
    <dbReference type="eggNOG" id="KOG0318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015246_1_0_1"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="368"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="521"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="609" mass="66247" checksum="5515CFDFFAC75B0C" modified="2011-11-16" version="1">MSIEPIALYPPHPSTVRAQATSLTYDKVNGRVAYAMGRSIFVRPVDPHSAVKSFQFSKHTAPTTVAAFAPNGNYIASGDESGHVKIWDTSVYGDKDVLKEAPLVKSDFPILSGAIKSIAWDADNSRVIAVGEGKEKFGHCFTWDSGNSIGEIQGHSDVINTVDIKAQRPYRAATAGNDKAVVFYTGPPFKFDKSIRDHHTNTVRAVKFSPDGKYLLSVGSDRLVVVYDGKTGEFVTKIENAHEGGIFGVWWFGDSKKFATCSADNSVKVWSVESWESTQTLKVGDAVTVENQLVGLVVTDKYIIALSLNGNLNYFDVDDGSLQVVQGHQSAITATLVVGHSLVTGGSDGSIYKWTIDGDSLKSVPQFVGGHSNYVVDLAYDKNLISVGWDDKLKVWDLDNGTSVSETVLVAQPKKLVKQNGSVSVLFENSLTDFTITESIQKGTDTVLKYDSSDVDVLAEKLLLTNLSDNKIESASLKFDVIRGSPSLVRVSPDEQYVALGDSTGKYIIYNADASIKTTRWTYHTSKIVDAKWSPDSQFLLSGGLDSNLLVYSIKRISKVVQAPLAHQSGISRVEWLHYDFEGSGHGVVASTGFDGAVKVWKVDLSVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8D9</accession>
    <name>G3B8D9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_107547</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8D9"/>
    <dbReference type="STRING" id="590646.G3B8D9"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_9_2_1"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05384">
        <property type="entry name" value="CAP_PRY1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000012">
        <property type="entry name" value="Secreted protein PRY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SCP" evidence="6">
        <location>
            <begin position="27"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="178" mass="19311" checksum="631E5AA990BFFDB1" modified="2011-11-16" version="1" fragment="single">TSPTTPTTTSPTTSSTAVATSTGDLSDFQQSILDEHNIKRDLHGVQHLQWNSTLAQYAADYAASTFSCNNVQLIHSGGPYGENLAAGYKGGASPVDAWYDEIQYYDFSNPGFSESAGHFTQVVWKSTSQLGCAYVTCDNAWQQYTICEYSNQRGNIVGTDSATGKTYFEENVVEPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8K8</accession>
    <name>G3B8K8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_108753</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8K8"/>
    <dbReference type="STRING" id="590646.G3B8K8"/>
    <dbReference type="GeneID" id="18246058"/>
    <dbReference type="KEGG" id="cten:18246058"/>
    <dbReference type="eggNOG" id="KOG3471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027280_4_0_1"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="428"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="498" mass="56816" checksum="626137DA776E402A" modified="2011-11-16" version="1">MSTGDLFKVTVINHLESLDDNTQSRLYAAPATCLSIYRLLPPMAKFHIMSMLFYEKNVAIKDLEKWSKPNTRHLQIESLERMRSLHLVQLSESGKYIRLHPIFKKNFADCLTGNQAPDAFGNLDTTVEKHTVDLKFLDTFASTKWETILHYMVGTELSSTPSRSVLRLLKSGGLMEGNSDYAQELKITNKGFQFLLQDINAQIWTLLLQYLDLTLELQMDAVDVLNFIFLLGSLELGKSYSVSALSDTQIEMLSDLRDFGLVYQRSATSNKFYPTRLATTLTSDSNSLQTPSMAIDKANSGIDSTDSKQRQESIIIETNFKVYSYTQSPLEIAILNLFVHLRTRFANMVTGQITRESIRNALYNGITAGQVIKFLETHAHPQMKMLAQEKLDKKIEFDASNNINTATGKSTDAPMQHKLEILPPNVVDQIKLWQLELDRIQTFDGYLFREFNNQIDYESLRNYASEIGVLVWSDDKKRTCFVTKEGLKQVSNFSSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8P6</accession>
    <name>G3B8P6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="7" type="ORF">CANTEDRAFT_107268</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688575.1">
        <property type="nucleotide sequence ID" value="XM_006688512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8P6"/>
    <dbReference type="STRING" id="590646.G3B8P6"/>
    <dbReference type="GeneID" id="18245943"/>
    <dbReference type="KEGG" id="cten:18245943"/>
    <dbReference type="eggNOG" id="KOG1076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004304_0_2_1"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="590"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="792"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="852" mass="96986" checksum="7CB9DC7679ABC7B0" modified="2011-11-16" version="1">MSRFFVKYDSDSSSEEEDLLSSDEEEALVVSSSPEQEDDDSDFFKDSDSESDSDSDSDAPKGPSYFLKRSFLKGGNDSDSDSDGEDRRVVKSAKEKLFDDIKETIDKLEIAKLINNWINALNEFDKLGKLLTRSHQQNFGTPNFYIIALADLEDFVNEANTNNEDKDKKKIPADQSRAFNTLRQRVKRHAKEFQALVDLRRESPELFESEDPVEVPLASGVSKTGEESGFAPSSASRNLSPVFTTLKQISESRGKRNIDKFEQIQILETLLQETISGKTFELISIYQMLISVRFDASANQTFMPLDQWQKNLNDINLFLDLLKKSSTSYQVSELGKTTDDIDIEPEANADGVKIIFGSISSLIERLDDELTRSLQSTDPHSIEYVERLKDESSIYKLILKGQLYVEFTTPQDKITEVNDQLSRIISRRLDHIYYKPDQLIKSNERDAWESVDASTKSVIASRGASPKELVEGLVDFLSENSTEIYSKKALLSKIYYFAVNNDHKTANELFVSSRIYSTIHNADSSLQIMYNRALVQLGLSAFRVGLIEESQLALNEIAYSQRSKELLGQGFNTKYPSQATVSERQKLLPFHMHINLELLECVNMTSSLLIEIPALAQSSSSTKDSKRKASARSFKNKLEFHDRQYLTGPPESIKDHIIHASKALQKGDWSKAYNLLASIKVWKLFPNNAELLEMMKHQLQVEGLRTYIFTYKSVYTKLSVDLLSTNFKLEDDKVVSILNKMIESGDINASLSEDKKFINFSSNETQRTRLQELAIILNEKVGLLTEKNEKTAYHGRGRKSHQQNQDGQQRDQNKEQTPQQQSKDQREPQEEYVNRFRLANVNSNNDEFQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Z9</accession>
    <name>G3B8Z9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_131301</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Z9"/>
    <dbReference type="GeneID" id="18249511"/>
    <dbReference type="KEGG" id="cten:18249511"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_0_2_1"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36233" checksum="3FBA344A2931C95B" modified="2011-11-16" version="1">MSLLIPTAQDYKDARAGYDLLPAYRESLEQRRHEKTDEGKPKFGWEFSVEPGFFHQSDDSTDDLNFNYATHDFGRKEPWDELTARLARLNGQSATTKYKLLFLARHGQGFHNVIVSKYGSAEWHRKWHRLGRDGDVEYAPDPRLTRLGEAQGRENHAVWRAQLAAGCPLPTRYVASPLQRSCNTLLLTMGGLWPENTAVEVVESVREIIGYHLCNKRSTKTQILERFSSHGFVTEPGFTEEDELYTEQEEKFDDMCFRMNGFLQRAFDEWDDSVLNVTSHGGTIKCLLAVVGHRNFTISTGGMIPVVVKATRTQERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B902</accession>
    <name>G3B902_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_125009</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B902"/>
    <dbReference type="STRING" id="590646.G3B902"/>
    <dbReference type="eggNOG" id="KOG1646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046346_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="236" mass="26704" checksum="EEBBA0A572E38583" modified="2011-11-16" version="1">MKLNISYPANGTQKSVEIDDDHKLAVFMEKRMGQEVEGDSVGDEFKGYIFKITGGNDKQGFPMKQGVMHPTRVRLLLTKGASCYRPRRNGERKRKSVRGCIVAQDLAVLSLAIVKQGDSEIEGLTDASVPKRLGPKRANNIRKFFGLTKEDDVREFVVRREVTKGERTYTKAPKIQRLVTPQTLQRKRALKAKKIQNAQVQRDAAAEYAQLLAQRLHERKAEKAEIKKRRASSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9E2</accession>
    <name>G3B9E2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_136427</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9E2"/>
    <dbReference type="HOGENOM" id="CLU_098504_0_0_1"/>
    <dbReference type="OrthoDB" id="3996163at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442774" description="PA14 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="31"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="269" mass="28694" checksum="FFB27FBCE50AEFE4" modified="2011-11-16" version="1" fragment="single">MKLTSLLSGLAILPYIFVAGIEVGGCDPDATAISGLKAEFFSVSSWEVDTPLTPSKLETYLQTMDQYSVVCTGNTGSDPNFYYPAATIGGSTTLYDCPIKTNAIGVRLTGYIYASEPGTYTISSYFNNVGVLTVGNGNAMSSCCSNDSVAYNKADDNWLASSNSGAATDTGTTSESYDLKAGYYYPIKFVFYNGYTGDGTFDISMVLPDGTHLTSDFPFYEFNLTDNSACPIITTTTGIWTVTGSDGDVTVTEEVPESRTTTTEPWTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9H1</accession>
    <name>G3B9H1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_125166</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9H1"/>
    <dbReference type="STRING" id="590646.G3B9H1"/>
    <dbReference type="GeneID" id="18249085"/>
    <dbReference type="KEGG" id="cten:18249085"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_3_1"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="100"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="196"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="280" mass="30935" checksum="FF715E9FC9434D78" modified="2011-11-16" version="1">MEDVNPVKELCFGAISGVIGRIIEYPFDTVKVRLQSTQPSLSTVQIIKSTYTNEGIIRGFYQGVKAPLVGSCFENAILFATYNTSLEYLHRQFGQPGSEPQLQYKCVSGGIAGFVASFLLTPVELVKCQLQVKNLVRDNRTRHLYSTVIGDVVKKDGVLGLWKGLGSTLLREINGTAIWFGTYEVVSEYLNKKNPGSSLNPLTSGAIAGITFNFAIFPIDTIKSNIQTNAVLSSTDTTYWKTMKKVGIRNLYNGLGITLIRSIPANAMIFYSYELLKNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9K9</accession>
    <name>G3B9K9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115371</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688869.1">
        <property type="nucleotide sequence ID" value="XM_006688806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9K9"/>
    <dbReference type="GeneID" id="18247837"/>
    <dbReference type="KEGG" id="cten:18247837"/>
    <dbReference type="eggNOG" id="ENOG502S20Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112963_0_0_1"/>
    <dbReference type="OrthoDB" id="3997736at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="211" mass="24621" checksum="AC64B8167490DAA9" modified="2011-11-16" version="1">MLLRSIKGTIRECRRSIQTHIGPPTHFSSKHAPPNYNELSNSNSIEVEVQRAPETQERQKEHEGDKPIREFSSLLAMMTLGYFAVDNYLNRVKLEKLNNESTSINLKTLQIQQANFAQERRKKDLQLLQERKETQRQLFKLSVHIAMLRKQLADQGYDPVNIDQALKEFEDSVKIDNSIKNISGQVLWLDKTSDLRRYLPDIHDYEKKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9L2</accession>
    <name>G3B9L2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_135843</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9L2"/>
    <dbReference type="STRING" id="590646.G3B9L2"/>
    <dbReference type="eggNOG" id="ENOG502S831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639340_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="429" mass="49461" checksum="2401F7605FA5F36D" modified="2011-11-16" version="1">MSLPEFEKVQSQSSAFKYPGSNWHASSSETSLELGNSVPDIYGKCFNSFGAERMGFLDSEEMLQSISINLDYTTLDILKIHVLRLGMVMMYVCFHYVTWLIGIYSDSTELFTVAKNLITFKLLFHIGKLVTTMKKLITLQVVNIQTNSFNYIIDLIPSSLTLPKSIAIVEYASDYDISVSLRLPKPYLTYDKTWVKPSDEDIQAVLKPREEYFVNQRKFLYYENFRILNNFSRLVVWCGMINVSLINLVSNINYSHLKTMVLSEFKYQFGFLKNCDSRVLSKLVPIIRVVDGPGDYVFDPLDILIETKVVANDITPISTLKPTSDQQEKIEGEGTILPTILEEASEANQKVRGNKDSDWEDDTRRELTINLRHQDTEICQLILLPNTKYIKLQDYKPEVYFKSGVIYRSCRSFSVNLFINSLHQYNKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9R5</accession>
    <name>G3B9R5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115407</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688123.1">
        <property type="nucleotide sequence ID" value="XM_006688060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9R5"/>
    <dbReference type="STRING" id="590646.G3B9R5"/>
    <dbReference type="GeneID" id="18247854"/>
    <dbReference type="KEGG" id="cten:18247854"/>
    <dbReference type="eggNOG" id="ENOG502RYS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046455_1_0_1"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="360" mass="40737" checksum="3AE8B9F6A285BA66" modified="2011-11-16" version="1">MLPDIAFGYPLPKDAGISTFRSTRVHSLNSLLKDQSYHFQSSTGLRKIAKMSSKFFNPWNNSPTPSVEEMLSQKPNHVEFEMNQNLETSNHRDFYMDSNKSSSAFSSTSRNFSVFRPQRGSKEVPRLTNSNQNLMSKTHKSACSESLDSKRILVVKGMIPKSSCGAILTRISGGSLERAVFKDDSQSPSLELYFIFPKEAQKFFEYSQTGLFCYNGNPLQVEWASERNTEDISSFHPSIEKKLLDQISKGARRTLLFTKGTPKISKRTENHSHFPNQSVNFSPNFNIKNVIADLAPMGNIVEFTPLISGSLSFRVSFDDVRTAINIMRQWQIAGTMLNFKYSGWVLHYGKDTCEKPCLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9Z2</accession>
    <name>G3B9Z2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_130957</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9Z2"/>
    <dbReference type="STRING" id="590646.G3B9Z2"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_1"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="867"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="413"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="892" mass="99501" checksum="3FAA9E7E3E271285" modified="2011-11-16" version="1">MDETQFTDNALRIINNASQLAKENAHSQLTPLHFLAAMVPTDDENSVPYLKTLIQKSRYEWGDFERAVNKHLVRMPSQNPPPDDIRPSYQTGQVLQNATKIKAQQKDNYIAQDHLLLALLEDSSIKDILKECGIKPDVIKTQAIELRGNQRIDSRQADSSSSFEFLNKYCEDLTEKAREGKIDPVIGREEEIRRVIRVLARRTKSNSVLIGEAGVGKTSIVEGVAQRIIDGDVPNVLANSRLFALDLGALTAGAKYKGEFEERIKGVLNEIEKSNEMIILFIDEIHMLMGDGKSDAANLLKPMLARGALHCIGATTFAEYRKYISKDGAFERRFQKIDVPAATVNETIAILRGLQPRYEIHHGVRILDSALVAAAQLASRYLTYRSLPDSAVDLIDETAATVAVARDSKPEELDNLERQLHLVEVEINALERDVEADEDSKDRLKLARRKQEEIEEKLAPLRERFQQERAGHEQLIAAKRRLDELEIKAQDAERRHDTATAADLRYFAIPDIEKQIQVLEVKVQEEEQSVGADSLLRNVVGTEQVAETAARLTGIPVTKLTQAENSKLINMEKELSSAVVGQSDAVKAVSNAIRLQRSGLANPNQPASFMFLGLSGSVAGFLFADERAILRIDCSELGDKWSASKLLGAAPGYVGYEEGGILTEPLLRRPYSVILFDEVEKAAPEVLTVLLQMLDDGRITSSQGKLVNCSNAIVIMTSNLGAEYINASRGSKIDESTKELVMTAVRSHFRPEFLNRISSTVIFNRLSKKAIAKIVRIRLKEIQERFAANSKQLTLDIDDAALDYLCKNGYSSDLGARPLNRLIQSEILNKLAVYLLKGQIRDKEVARIRLGHKGLEIVPNHEVEDVDMEDVDVEQWEDSDDQDDDLESTPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA16</accession>
    <name>G3BA16_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_99092</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688158.1">
        <property type="nucleotide sequence ID" value="XM_006688095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA16"/>
    <dbReference type="STRING" id="590646.G3BA16"/>
    <dbReference type="GeneID" id="18250824"/>
    <dbReference type="KEGG" id="cten:18250824"/>
    <dbReference type="eggNOG" id="ENOG502SZ4C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093900_0_0_1"/>
    <dbReference type="OrthoDB" id="4008582at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="238" mass="27153" checksum="57FE47B994DAE2B3" modified="2011-11-16" version="1">MIRSMEHIVDEYLLEVSSTPNNPVLVKLMLDKISNDLIPIKLNLNKYKSNKLYDTINDKLIELIHNLDTLKHKNTKKLAQMKRQSIAATHPSQVVIDDHSDPRSNLSPSTYSTGVRNNDVNELRKRLLENNRSSLTNDYHETLQQDLIHDLSDMVSDMKDGAIRLSKKIMDDNVLLSRTQDNMMKNDSLMNTVGSNLTSYVLNKSGGKISFWFLIKTMAAVVVLFLIMSIIINILPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA91</accession>
    <name>G3BA91_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper-fist-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114861</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA91"/>
    <dbReference type="GeneID" id="18247611"/>
    <dbReference type="KEGG" id="cten:18247611"/>
    <dbReference type="eggNOG" id="ENOG502QQ0T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031396_0_0_1"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="303" mass="33802" checksum="19852901ABA52DFB" modified="2011-11-16" version="1">MIVKEEFKYSCIECIRGHRSSLCKHSERPLLQVRSKGRPTISNNPNYRIAIFAKHVEPEGKAIRIIQSSIEYIIDITTRDIIGPYTEESQIKVTQHEVNSDSFIVATSCCSNGLVRNRSCGCNHTNNKSKILKKYLNKNKKKFKFIDNNHEAKQESLRDQLRRSVRASQSAVAPCFCGDDCQCESCAVHHGENYDFDIRSELDTAIREMGLGTSFVSTPASTADSSVPALAVSDFNLMTYNYQPVQAQSSAVARASSPTDSSPVECRCPDNDCKCSNCETHGIINGIKLDDIFANIDYRLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAC5</accession>
    <name>G3BAC5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_109031</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAC5"/>
    <dbReference type="STRING" id="590646.G3BAC5"/>
    <dbReference type="GeneID" id="18246079"/>
    <dbReference type="KEGG" id="cten:18246079"/>
    <dbReference type="eggNOG" id="KOG4034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132729_1_0_1"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="124" mass="14072" checksum="632906E31874198B" modified="2011-11-16" version="1">MKPSPTVLRTIKPRSPSVPEPVFQIPSLSLISFADLPNNGFGNGNYFISKTKFGHWPIYKKVQNTKITTEIKRIQGDVLQFKKDLVSLTRLNPKFVTVNQTAGYVNVKGDEVERLRSVFDKHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAM2</accession>
    <name>G3BAM2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114913</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAM2"/>
    <dbReference type="eggNOG" id="ENOG502RZ25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063516_1_0_1"/>
    <dbReference type="OrthoDB" id="4096201at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="367" mass="42081" checksum="E4C5D5BC31B6287B" modified="2011-11-16" version="1" fragment="single">MALCSQAFNKSIKRSCSATDSGATTKKTCFNSYRFPGCTLASRAIDTDTTARGVSSSDDDENSDDEQLCYKLHQIKAKRRASSRISFSLNPNLELSKFISKYSDEDEDGENHSPKNRSESDFRPYSSPPVPVEEQECDFKLVQVPKADKVSRSKCFEYLVGAIDEAWARYCDATSCIEDEVFYSDDNNNRREISQYMKGPRGASTTNAGSSYYYNNGNNTNNDDASDDHGRTLKDSDYEYDDEELEDDKSEIIDNYSVNSTDLTDMSDHYDQKSKVLANYRNNQLLSIKRSNSNKSTNQYQKMKDRLTKAKYYLQDLVDSDDYQDIQNFWNRWDMIKYATIELVEDDDDDEVIESTIDDLEAGRYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAP7</accession>
    <name>G3BAP7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_94961</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688245.1">
        <property type="nucleotide sequence ID" value="XM_006688182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAP7"/>
    <dbReference type="GeneID" id="18250459"/>
    <dbReference type="KEGG" id="cten:18250459"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="238" mass="26118" checksum="86DBB8EC38E06ED4" modified="2011-11-16" version="1">MSTYLITGANRGIGLALFKQVAAKSENTVIVTVRDETKAEQIKKLGYKNVHVIVIDIGDTLEAFEAAFKSLPELAPNGFDAVIHNAGVLSEGTMSKFGDHKLSEFQRVWDINFLGAVKFLRSILPILDLNNKPVKVLTVSSSGGTISEMVFACNSYGASKAALNYITKEIALERKERGDIFVPIHPGVVDTDMTTELKGKYHLISAEESAAKVWELVDKLTLEDSGKFWSYDGSELPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB82</accession>
    <name>G3BB82_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_98719</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687682.1">
        <property type="nucleotide sequence ID" value="XM_006687619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB82"/>
    <dbReference type="STRING" id="590646.G3BB82"/>
    <dbReference type="GeneID" id="18250798"/>
    <dbReference type="KEGG" id="cten:18250798"/>
    <dbReference type="eggNOG" id="KOG3221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079400_0_0_1"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="197" mass="21813" checksum="526A87376472997E" modified="2011-11-16" version="1">MSTFFDEMKKSFVDVPVVDSKIETTSFLDASASLVKLFDLLGSSAFVVVQKDMTGNIEKIRKKLLADPANASTLQDLILSEAGTKDKTATQGLLWLTRGLEFTCQAMVETVKNPQSEMTKTFTDAYGVTLSKYHGMLVKPVFKLAMKACPYRKDFFAKLGPDQEKVTKQLTAWLDALENIVKIIVDFFASGNYGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBD7</accession>
    <name>G3BBD7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_99227</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBD7"/>
    <dbReference type="STRING" id="590646.G3BBD7"/>
    <dbReference type="GeneID" id="18250838"/>
    <dbReference type="KEGG" id="cten:18250838"/>
    <dbReference type="eggNOG" id="KOG1651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_2_2_1"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="160" mass="17725" checksum="9B6FB9C417AE972C" modified="2011-11-16" version="1">MSAFYDLSPKDAKGESYPFSDLKGKVVLIVNVASKCGFTPQYKDLEELNKKYKDQGLVILGFPCNQFLGQEPGTSDDIASFCQLNYGVSFPVLAKIDVNGDNADPVFKYLKSQKSGLLGLTRVKWNFEKFLIDKDGKVVQRYGSTTKPLSIGPAIEKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBF6</accession>
    <name>G3BBF6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_125790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688979.1">
        <property type="nucleotide sequence ID" value="XM_006688916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBF6"/>
    <dbReference type="GeneID" id="18249129"/>
    <dbReference type="KEGG" id="cten:18249129"/>
    <dbReference type="eggNOG" id="ENOG502SB1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4031013at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="194" mass="21052" checksum="76853B39C2E68F13" modified="2011-11-16" version="1">MEPIQDDNDQISFQYANDCDLEIHCSPFGLSGLYIKVKGTNIMGVGSTMGLITGSTKGLIHYNDSQDLMDQKYKLYLVVEDDGMLRIDFTKISPLAQGSEDISAGPAGVKLNKKDEESVGKSPASVSTGGSSSYQSSSKSPKPLDKIDTGNTLEGETNLEEDSMPSLIFRGKCPDGRPSHIQPFIGIFSFERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBL3</accession>
    <name>G3BBL3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tyrosine-protein phosphatase CDC14</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_135511</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBL3"/>
    <dbReference type="STRING" id="590646.G3BBL3"/>
    <dbReference type="GeneID" id="18249883"/>
    <dbReference type="KEGG" id="cten:18249883"/>
    <dbReference type="eggNOG" id="KOG1720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017787_1_2_1"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000073">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="188"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="257"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="489"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="489"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV61566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="567" mass="63947" checksum="5D70AE7DE9948A8C" modified="2011-11-16" version="1">MPKNKSTIPLIEFLKNRIYLGAYDHTPDDTAQLVYFTVEEALPYNSFHLDFGPLNIGSLYRFAVILHNILNEEANQGKAIVFYSTTGPKERANAACLLSCYMVLIQSWSPHQVLQPIAQIDPPLQGFRDAGYSSADFEITIQDVVYGMWRAKERGMIDLTSFNLEEYEQYERVDQGDFNMVSKDFVAFASPQQNHRKSGSLNEPFKKVLNFFLKNDVQLAVRLNSHLYDANEFTKRGIQHIDMIFDDGTCPTLEYVQKFIGAAECIINRGGKIAVHCKAGLGRTGCLIGAHLIYTHGFTANECIGYMRMIRPGMVVGPQQHWLYLHQNDFRDWRHTMCLDNRPDSFIGGLFPLVPYDEFKSRVRQEAKQRKLQNQQSLNSSVGHIDSSFQTPIRRRKISGALAAKIQTAVPQESPGQPRKINEENSGVVEIFNNSDDEEFIEHPTDHMQDVQVPNRTGTEIELSANDMNDDIRSSPNRDALRSISANQHYHTASQITKTTTKARTISGFSSSPQNQTQTHSSPLIKNKSRSPSRIGSGITQSRYANASPVRVISNGGVRKVSGSRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBN4</accession>
    <name>G3BBN4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="9" type="ORF">CANTEDRAFT_107512</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687750.1">
        <property type="nucleotide sequence ID" value="XM_006687687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBN4"/>
    <dbReference type="STRING" id="590646.G3BBN4"/>
    <dbReference type="GeneID" id="18245957"/>
    <dbReference type="KEGG" id="cten:18245957"/>
    <dbReference type="eggNOG" id="KOG2994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_2_2_1"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="8">
        <location>
            <begin position="157"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="352" mass="40308" checksum="3EBC29D167F97E6D" modified="2011-11-16" version="1">MSNTVDSKRVSETQHPERNVVVKRTKITDFFSVKKKPAPPKDVSSTESKQTIKTVTTTTTLKLKPTQPAETAQQCDSLDEDAFSTKYNFNKKKWIESLSPKYLELLDLEINYLHISWLTFLHKELTKPYFLKLKRFLKAQAHKTVFPPKHQIYSWSHFTPLPQLKCLILGQDPYHNFNQAHGLAFSVLEPTKPPPSLKNIYKGIQNDYPKFEPPNSSQGGGGNLTKWAKRGVLMLNTCLTVEAHKANSHSKQGWETFTQEVINTAINYHQNQENSGFVVMAWGMPAQNTVGQFPNLQKTDNFLVLKTFHPSPFSAAKGFFTAQCFRKCNEWLEQQGKQRIDWALLDSNQIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBQ5</accession>
    <name>G3BBQ5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115679</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBQ5"/>
    <dbReference type="GeneID" id="18247962"/>
    <dbReference type="KEGG" id="cten:18247962"/>
    <dbReference type="eggNOG" id="ENOG502SCWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1864866_0_0_1"/>
    <dbReference type="OrthoDB" id="4077720at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="1">
        <location>
            <begin position="38"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="137" mass="15281" checksum="BB9E8F72B744C740" modified="2011-11-16" version="1">MSQTSKPDSPESGDSLPEWSGLQVKLRFSPTYVEAHQGEDEFESVNIDILTWTAIISAGIGKLYGIVGQALYFKVEDLGDGHSCTIRVMKEDEKQFLNSFFSHKFKLNSFYGGSVDAETYVVHLQTIPLGVPEEPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC51</accession>
    <name>G3BC51_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_128415</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC51"/>
    <dbReference type="STRING" id="590646.G3BC51"/>
    <dbReference type="eggNOG" id="KOG2098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018702_4_1_1"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="534" mass="61079" checksum="2E758C165188FB50" modified="2011-11-16" version="1">MLPVTYTLAFFFNMTEASGIWELEQFKPLVEFVLDKNDEVLGFPVLGDLETVFSMYQDRLTNTNHILKQMDFNNFQSYVNSFNDITGGSLELEQNGSQGKRVVHIEKVKIYLFQDRLNGAPLKHISFKTSTKFHPDEAQKPTEWLLKALAGELGSHIEISSETSVGAVELYANKTQLKQLLEKPSALVLLSRQRAKSITARKPFHEVCKNSTHAKVLSNIFVSIDKCYQSIEQSQKLFSKGIYECSKSKTHFLPIIHSNTDIGLGDCSYLDTCHKMKSCRYLHYFTLVPKSKKKVDVQAELAMVKKNIAKSEYTVGFCFNEFFKPQLPAQWIRCDIRKLPFSVLGKFAAIISDPAWDIHMSLPYGTCSDEELMELPMNQLQDEGVMLLWVTGRSIEIGRKALVKWGYKVSDEIIWVKLNQLQRTIVTGRTGHWLNHSKEHLLVGLKGDPSWMSRSVDTNVIVSATRETSRKPDEVYDLVERLVGPSARKLEIFGRDHNIRPGWFTIGNQLTGVNIHEREISEKYTKYQQSLKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCL9</accession>
    <name>G3BCL9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RWD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116254</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCL9"/>
    <dbReference type="STRING" id="590646.G3BCL9"/>
    <dbReference type="GeneID" id="18248215"/>
    <dbReference type="KEGG" id="cten:18248215"/>
    <dbReference type="eggNOG" id="KOG4018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084528_0_0_1"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="230" mass="26435" checksum="9290EC3341DCAEA1" modified="2011-11-16" version="1">MDPLEEQQQELEVLDSIYPDELEKHSESSFTVSIKLDTTSSKIHTLVLSVKYPPEYPNEPPQMTLAKEEEYEANDDSDDDSDEDARQLARNINLPEQVSFDRDDLKSILAKLNEEAELQLGMPSVFAIITLMKDEGEDLFRRKLGVLEKHREDELNKQEAESSKKFIGTKVTTESFNKWREQFRKELGVDERLANFYKAQHGGKMSGREIFEKGLANDDDLVEAFDSVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD34</accession>
    <name>G3BD34_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116954</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD34"/>
    <dbReference type="STRING" id="590646.G3BD34"/>
    <dbReference type="GeneID" id="18248519"/>
    <dbReference type="KEGG" id="cten:18248519"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001767">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="213" mass="23104" checksum="C5E84893DFFB49DF" modified="2011-11-16" version="1">MSFPNPAKAVKLVLLGEAAVGKSSLVLRFVSNDFQENKEPTIGAAFLTQKCTIGDKTIKYEIWDTAGQERFASLAPMYYRNAQAALVVYDITKPASFLKARHWVKELHEQASKDITIALVGNKYDLVEDENDGDTLRKVSVEEGQKLAEDEGLLFFETSAKTSYNVNEVFVGIGTKIPESSAPTGVQQAGNEAGRIDLTTGAASTTQQTSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD75</accession>
    <name>G3BD75_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116318</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690286.1">
        <property type="nucleotide sequence ID" value="XM_006690223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD75"/>
    <dbReference type="STRING" id="590646.G3BD75"/>
    <dbReference type="GeneID" id="18248246"/>
    <dbReference type="KEGG" id="cten:18248246"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023305_0_0_1"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="12">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="11">
        <location>
            <begin position="130"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="197"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="180"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="532" mass="57373" checksum="AF74285867D588A6" modified="2011-11-16" version="1">MAKGESCSFLIEKFSNVKSVANLNTWNELTPTPDWNGCSNLLLGQQVCVSEGGYPNKKPAENSDGSCHSYTVKSGDTCAALASTYYPLTTDEIESYNSDTFGWYGCSKLTKGQKICLSAGTAPKPTTDENAQCGATAPGDLYNTECPLNACCSQYGYCGITSDYCATTTSTTGAPGTFGCQSNCGYGSLHTSQAKTFRNIIYWLDSTGDLASDPTQYSTSDYDTMHYAFVNINSDLTIDTSKLAVSDFLKVSQKKVVSFGGWDFSTSTSTYEIFRNIVSTSTSRSNFASQVVQLISDYDLDGVDLDWEYPAETGIADIPDDYSGNGKKFLSLIKTIKGSLPSGKTLSVAIPATYNYLKNYPVADMQSYVDYFVFMTYDLHGTWDDSTTTGVQCHTDLTAISDAMLMLDKAGVKMWKLVGGIATYGHTYKLSSTSCTALGCAFSGAGDAGSVTNSAGILADSEINAISSSSKKVKRWSDSTINCDIMVYNTNNWVAWPKASERATLKTYFKDHAMGGSAIWAGNYLAHSAYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDJ9</accession>
    <name>G3BDJ9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_116369</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDJ9"/>
    <dbReference type="STRING" id="590646.G3BDJ9"/>
    <dbReference type="GeneID" id="18248269"/>
    <dbReference type="KEGG" id="cten:18248269"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_3_2_1"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="267"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="466" mass="52896" checksum="E24AAC03C3F84822" modified="2011-11-16" version="1">MSKEDFVIKPENVEPSKDTSSWPLLLKNYDKLLVRSGHYTPIPSGCSPLKRDIKSYVSSGVINLDKPSNPSSHEVVAWIKRILRSEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDELKDQKDLGRTLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGAMDENDNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRYEEGIEIYDEVVLMTTKGEAIAIGIAQMTSVDLQSCDHGVVAKVKRCIMERDTYPRRWGLGPIAQKKKQMKADGKLDKYGRSNENTPETWKSEYKDHDDEPAPPVPASKLEVPEVQLPKKSTEVIEEDTNEKKEKKDKKEKKEKKDKKEKKEKKEKKRKAEDEESPKKKKSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDP2</accession>
    <name>G3BDP2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enhancer of translation termination 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_116399</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for correct translation termination and probably involved in regulation of hypoxic gene expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ETT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDP2"/>
    <dbReference type="STRING" id="590646.G3BDP2"/>
    <dbReference type="GeneID" id="18248285"/>
    <dbReference type="KEGG" id="cten:18248285"/>
    <dbReference type="eggNOG" id="ENOG502QPHX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050427_0_0_1"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000640">
        <property type="term" value="P:positive regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024318">
        <property type="entry name" value="Nro1/ETT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28290">
        <property type="entry name" value="ENHANCER OF TRANSLATION TERMINATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28290:SF1">
        <property type="entry name" value="ENHANCER OF TRANSLATION TERMINATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12753">
        <property type="entry name" value="Nro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="402" mass="46224" checksum="BE2E241F483A4625" modified="2011-11-16" version="1">MAKRQLGLSKAKKRQKTESGSTGPSNVLKEPVSAENVTIELPASVSDDEFVQLKSLYSKYKSEQNELILNGVIHECDRLIRNEDSQKTPAFFYALYSNSLLELINYRDPSEVGDLIDLSLEKVILGIEVFPENIELQFQTSKVLLNQVMHQLGELKELKHTKSYDLEKDLARALSAFEKAETSSEIQDNFQLYNEETFETIKLFDEILEVVDNFGKSNLDNDSDEEEEDKDVQEEDSNVPESIQNIRESDEFNQWWRDHVIKFYKVLQKQDKKPEKLYKTVCFNLGQSYLKEAEEPANIFTTLKYDDSFTDSEINGLDEATAQAIGIELFQTAINYLRQSWDDEDVSTWVNLSESLISLGNLHELESEDQTKCYAEAEKILVRANNVTNGKYKDILDNLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDT6</accession>
    <name>G3BDT6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_95827</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDT6"/>
    <dbReference type="STRING" id="590646.G3BDT6"/>
    <dbReference type="eggNOG" id="KOG1977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005415_1_0_1"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="380"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="561" mass="62299" checksum="C3AC14904DEA7362" modified="2011-11-16" version="1">MIKKLSSSVVERISSATAVASMDQAVAELVQNSIDAGANSITVKVDWKTLSTAVMDNGNGMSRESLAALGPHMTSKLSTWEDLVNCKTYGFRGEALASLRQISNKMVIVSRCRNDKSPWYVYSDINGNCCKVSSFDQDNELANPPNHNMFYIPSFEHGCMVLAYDMFANIPVRRRNILEDGVEKFMAALRRRLVVLDLPKLKVLVDGEVRIVTDRGPTTVNSVLGISCWFDRIRCRSGAYTVTGLLSHQCRKGYQFILLNNRLYNLKLQYKKSPVFVLRFSCAVSESELVQDPSKAIYTSCHEGNVVAILQKMFLEYFGEQVVRIPTSSPMKRSPVKSPRKASSSVTNNKLSPTKKSLSIKTCFNYPQSLTRADLHSIHVISQIEKKFILVRTGSVLAMVDQHAADERIRLEALQHQLLTSSTLVACNIPLNLTPSEKHEVSSHAEYLRPFVQFDPHGNVCQIAAAVSGKTSLEQDLLEYVADIRRGSKTVIGKCSWIEDIRNIPGFIISSVNSIACRQAIKFGCKLSHDAMSQLVSDLGRCQVPFACAHGRPTIVPVAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDW7</accession>
    <name>G3BDW7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_132175</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689613.1">
        <property type="nucleotide sequence ID" value="XM_006689550.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BDW7"/>
    <dbReference type="GeneID" id="18249598"/>
    <dbReference type="KEGG" id="cten:18249598"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_0_1"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="742"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1307" mass="142227" checksum="3B01F5BCA11449E4" modified="2011-11-16" version="1">MTVGNIKIAIDRGGTFTDVLAIIPGQPDFMFKLLSVDPSNYKDANIEGIRRVLEHIQNRKISKGELLDTSCISSIRLGTTVATNALLERKGERMAFLVTKGFKDLLKIGDQTRPDLFALRIIKPEPLYEEVVEIDEKVTIPGATEDPERVNFSSKVDGKEYILGASRDVFKVLKDLDESDSRLKLEQLRAKGIKSVAICLVHGYSFQDHERKLKQIAEEVGFEHISVSHELIPMISAIPRAQSTVCDGYLTPVVKEYIQNLLAGFAKGTENTTRIEFMQSDGGLCSWKGFTGLKALLSGPAGGVVGEAETCYDEDEGTPIVGFDMGGTSTDVSRYAGNYELVFKSTTAGVQIAAPQLDINTVAAGGGSILTYRHGVFKVGPESAGAHPGPACYRKGGPLTITDANLITGRILPQFFPKIFGPTEDQPLDFDIVEEKFKQLTKQINQENPDKQLTPYEVALGFLKVANFSMAKPIRVLTDSRGFDVSSHNLASFGGAGGQHAVSIAQILKMKRVVIHRYSSVLSAYGIALADVVQENQKPCHEKYTEQSRDQLLIDCENLVTTVKAKLIEQSIEENSIDVEIFFNMGYAGSDTFLMISQPKDGNFYKSFTEVHEREFSFVDRERDVIVHDIRVRASGSLSKIKEISPYKDLASLEASGRITAIERGIEVATTKIHFDEGVLDTEIFQLSDIPVGSLVAGPALILDTTQTILVTPASKATILNRHILVDLEEGGHSQFSTDYVDPILLSVFANRFTSIAEDMGRTLQKISISANIKERLDFSCALFDEEGDLVANAPHVPVHLGSMSNSIRYAKKYWAENIHPGDILATNHPIAGGTHLPDITLISPVFINGKIVFFTASRAHHAEIGGSVPGSCAADATSLYEEGAQFVAWKIVSNGKFDYDGVQKHFIDEPAQYPGCSGSRKIEDNISDLKAQIASNQRGVNLLLELFKEYGTETVLFYMKGVENTAENAVRSFLRRVAIEKKGLLPLKAEEILDDGSKITVSIDIKEDGSAVYDFTGTSEEAFNCGNAPIAITYACIIYCLRLMVNSDIPLNEGCLKPITPIIPEGSLLNPSPYAAVSAANSATAQRLTDTILKAYEISGACSGSNNTLAFGKGGIEAGVMKQGFAMVETIGGGIGAIDGYDGFSGVQCHMTNTKITDPEVLELRYPVVLHEFSIRENSGGDGKYKGGDGLERLYEFTSPLSCTMRTQRRVNAPYGMKGGKEALRGENRLGRRRDNKVQWILLPSFAQFKVEAGDFVRIRTPGGGGFGAPEEVSSVTTSKGPTPKVHIPLAGGTITQLTNLSNSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDX8</accession>
    <name>G3BDX8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein STU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_95858</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BDX8"/>
    <dbReference type="GeneID" id="18250552"/>
    <dbReference type="KEGG" id="cten:18250552"/>
    <dbReference type="eggNOG" id="ENOG502QT5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261691_0_0_1"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="318"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1463" mass="165119" checksum="CE090CE606E8174F" modified="2011-11-16" version="1">MVASSDVKTSVKIEYLNDLRLKIRESKGDKNSPILSVRAITNYIQGLQILDDMDNMELARTSFRTLSDLLKYAAIGGKITKEHARSVFPILISRLGDHDSKISASAEKRLDDIWLINNKEVQHGFEHIAFPHRNPDVVIKSLSWLLERANEYIQFNLERLILSIVKAINDNYHQSRMNVVNAFLEFLATYFMSHNDPASHKLAVKEVYSTKVEDYVRDSILNAINKNPSTVSRSRAPVLKASDEMQSYGFESSKKSPKKSTGDIQSELRSPFEVQSHHSIAPSEDANESISEASESESDLQAFTSRLDSYGFDDSIHTSDTYTVDDLHRLSRDLLPVFEGNETENNWQIRERNIMKIRMVLRSNVIGEFPEEFKSLLQRFNEAIRKALLSLRTTLSSNACQLIKESAMVLKESFDSLVDTFLPALIQVCSSNKTISTKNSHTAICAIIMSCSYSARFISKIDTWAADKNINLRAFTCSWLHIVFLRFHDFPNFCIQPASQNPARITSVSKTLGKLLADSNGTVRQAAREAFWSFVKYTPDVAESIFSKLDSNVSKGIERAAPSNIGSLSDIFETSKEVRGTNRSKGQPATKISSRISMPSRPASKSVFRQAAKPLPTVVKSIISRPATPNVISNIVQSRAPSRLSAQTSLPKRLGGSLVSDENSKRGISKLERSNSRNQPNQVFHSSSNVKADYSKPERTSSLKKVDAPVKSKKNAVISTNGPSSEHSNAVVKPISASIPTNTPASISISSKESPHKQVNPVSTSVSRVLDDRLPSLEFPLVYQLASSDITVIRTGIDTLKYALKFNETAEIPKNINIILSKLSRSHNEMLKPLFNYVALSKILPVFNLDDMLRVYFTLFEDVSESFVDELKSNFDSDKIYKAIDLVLINCLNCKKLLHSDPLFGEQVSIYKPVIIKSIIKFLSIDINEASSDSNFPIISNSVFHLINHISYESFDDYFELLTKVYSLNSSTFKMTLNYFESDYKSDIIELIQRIDNKEDVEMSSENDDSDDINLDDLIGQGENHTSSDSMNMHEVIAINDLNIGTRNNSQEQEEIRVSDSSSSEGSDKLQEEDAHIMSESKGIQLDTEAVANAQNAFSLGLSTDGKSKVVSVSEEDNVFLDRQSSSRNEIAEEFSQIDIRDRSSFEIKDPFQTLVEKVDPLKARAERNKQINIYEDSVHESKENRASSTDCSPRKHVDEVYDYSELNWFNFQLAHNSERFKSDVNRSEFENLTTRLGDKMINNDEVLRLINYLQSSIDFDMEFANYFYKEGSKKLEANLWKLFEKFSVLNKSQISNGLIIAKQLLITRMKIDLKKLIHTLVKLGDIEDESIVEFGYAISEIFEEVLRCKYPSEDILDVLMEATGHLNVEHPKNKIVMGFDLLLKFLIHYPLIGQKSGQKMAIFCNTTLYPLLSHQDIEVRRITVLNYGKILKSLQGANLDTKMIQESLSGSQKKLIEYYSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDY7</accession>
    <name>G3BDY7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF590-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_110843</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDY7"/>
    <dbReference type="STRING" id="590646.G3BDY7"/>
    <dbReference type="GeneID" id="18246226"/>
    <dbReference type="KEGG" id="cten:18246226"/>
    <dbReference type="eggNOG" id="KOG2513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015250_0_0_1"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="146"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="68136" checksum="64F6B2D3C3F7317B" modified="2011-11-16" version="1" fragment="single">MSISKSLKELEADFVVTYSSKKVDADLSQLLDLLEEKGFFCQIRDLNESSLLIFIKLSGYTYAELYEKDLIKNYEFGITSAIDNKADKLRIVYEYLSGSSPDDVNLLAHKHVADITPITESISSTNGLEDIKSLVTLSNAPSTSFIKENFGIHIALYFEFVKHLLVWLSGLSVLGLLSYFKSKHLFSLTYCSVNLVWGTFFLAFWKKREKYLVSFWGSANYHLIQEHKSELNDINKYYEEKSSYKHKNNYEGLKFLKQLLFIPVAVGFAAVLVAYQLGCFVLEIFINEIYDGPFKGFIGLVPTILITVFVPILTTIFNLVSDLLIKYEKHNNNYTKQNSVLIKQFILNFLTSYMPLIITAFIYLPFAHLIQPNLVHIKDSISYGANPNAFYYKYLTHIKNQEDFKMNQERLNLQFNYFIVTNQVIQLVLKYALPQIISLVKSFISKPTYEPVDKSNEKDYLNNVRKYVSLPSYDVNGDFRFVTIVYGYLILFGPVWSLAPLVTLVFLFLTFKLDYLKLSNGKYFKPPIPQKIDSIYPWNYALFILTWLGSIISPAITAFYHHGDKPPKSLGQFALDKASVNTKSSTLLIILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE80</accession>
    <name>G3BE80_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">V-snare-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_99890</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE80"/>
    <dbReference type="STRING" id="590646.G3BE80"/>
    <dbReference type="eggNOG" id="KOG1666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075474_0_0_1"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="122"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="220" mass="24883" checksum="DA81888290D0404B" modified="2011-11-16" version="1">MSDLFSSYESDFQLAIQDAKSKLSSVSAVSEAGQRRSALKSIEHATDECLELLDQMNLEVQNLPSNQKSQYNTKVRSYKTQVNECKTKLKQLLDDQDKYELFGNRYTDSGDGDDIHDDQRKSLLSNNASLERSSERLRDSQRIALETESIGGNILNDLRAQREQISGARNTLLTAEGYVDKSIQTLKSMSRRLTANKFISYAIIAVLIILIFLVLASKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE92</accession>
    <name>G3BE92_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116554</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE92"/>
    <dbReference type="STRING" id="590646.G3BE92"/>
    <dbReference type="GeneID" id="18248354"/>
    <dbReference type="KEGG" id="cten:18248354"/>
    <dbReference type="eggNOG" id="KOG1723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089419_1_1_1"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="203" mass="24244" checksum="B235D4A594A009B6" modified="2011-11-16" version="1">MRIYQCHFCSSPVYPLHGIMFVRNDSKEFRFCRSKCHKNFKQRRNPRKLRWTKAFRKAAGKELVVDSTLTFASRRNVPVRYNRDLVATTLTAMARVEEIRQKRERAFYKNRMRGNKERQLALDKKLIEGHPELLKIREVELRRKAERRAAKESAMEEDEDLDVSESEDENEDMMSMESESESDEESTKVKQKVLLKNKRKVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEF0</accession>
    <name>G3BEF0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_110716</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689743.1">
        <property type="nucleotide sequence ID" value="XM_006689680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEF0"/>
    <dbReference type="STRING" id="590646.G3BEF0"/>
    <dbReference type="GeneID" id="18246216"/>
    <dbReference type="KEGG" id="cten:18246216"/>
    <dbReference type="eggNOG" id="KOG1931">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009596_0_0_1"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055504">
        <property type="entry name" value="DUF7076"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055506">
        <property type="entry name" value="DUF7078"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056916">
        <property type="entry name" value="NTS_TR130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23273">
        <property type="entry name" value="DUF7076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23285">
        <property type="entry name" value="DUF7078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24967">
        <property type="entry name" value="NTS_TR130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Trs130 NTS" evidence="8">
        <location>
            <begin position="303"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7076" evidence="6">
        <location>
            <begin position="541"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7078" evidence="7">
        <location>
            <begin position="892"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="4">
        <location>
            <begin position="991"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1146" mass="132905" checksum="6741E21C7D9EAA89" modified="2011-11-16" version="1">MSVQLAYYDPFNVFPLIKPSLDSKLPLTNVHWRFNHSSALRSIPRLPVDLVEEVPKKVNDSIHVRLMFIQCNAIEIYKSQVRPLILEWLKHSVNDDVEWLIVLYSPIKKDKYSFKTSIFEKLKADFGKDGKHLSALTVNRGSKDRCFRLREPNDNDLNKLEVYNDLINFIKDLILASCLRNFETIDKQLSTIKDKDLFFVNLLLKKSMSFENLRLFKDSLNTLKDSTILLQNYYHKSPTSFKNILPEIDYKNVTAVFKECDILSETNYFYIISFVFNRKFKLLLTLVEDEDLFSIQCLYVSNLFQEMIDYLNILNSFFGDSVLQFNYHLIEYFMGHKVIKDFINTPAHEEVDTSYLHEFMGELKLFERSSLVKLGALRGYRIYEFNEVSLDDHGDKQKEIELVGELSRILKSKDSFLQYFENATETIIQHLVLCNRTKTIDVLSIDLALLNYQRQNYKESLNILQDSYQFFLDNNWNYMGGILLEIYVECIEKLSINNPALLVQSYIKLISNLKTTSEKVDINNYRLIKTQKQISKLSQNVIKGSESLQESFEFPIEKIFEVDLDPHIRNDGHNYYLELNLTNLYEIEFKFEHVELELSKGLTFKVGDVRLSEEKFQTVKLVSRRAVVGFFKPVKLTIGLSPKLKLIHTFTQVPDDPKHSILNDSMIFHNQTAQSEMETNSIYFYPSGDVFTCDIKMASDLLLGLPSIILTLKNGETPIQNVSVDFLTFEDFKYDKKNLELRKVDLEAGEKYLHEVPIQSLTDNKILKVKTLVRYDANETSYEFVTEKIIDTNLIVSVSVQDIFKSESIFSRFQVGSAISSPVRILSTQLVNADENSGTAYTIKVPRVTSENCIVYGEQMYTSFYKIELTEKHHVKPTDEFKLSVVYSSVVEECEEIMARLVHSEIESFSYAFNDMVMPKIRFDYQSYLLDSKLAILNILEITTLTDRIVQYLAPKERTKVRDSIINIINSTHSTTTTQDSFKLRSLNIYVPVSNIDILQIVEFKFNKKEKYVVGEPISVELAIESSLKWTSKHRILEDEQDISINAESSLLEDYPSKERFQVSIVNDDNWLISGFRKKIFSIDSKSQSTNKFNLVLIPLTVGKLSLPRLLIKLLDSRDLTMDISIKNGCETLLVVPELDNITFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEG6</accession>
    <name>G3BEG6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_95989</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEG6"/>
    <dbReference type="STRING" id="590646.G3BEG6"/>
    <dbReference type="GeneID" id="18250565"/>
    <dbReference type="KEGG" id="cten:18250565"/>
    <dbReference type="eggNOG" id="KOG1963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_348179_0_0_1"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="79606" checksum="3C110DB047B04945" modified="2011-11-16" version="1">MEWSISMTNGGKVLDFPVSTGVAGIYSEDGRYFLAILSHQIRVYFISTRQCTRTVDLDLSDCVDAKLDPSNSSNLIVYKTNEILKVNWKERLVNPVVSFGPVTEAISVVINQFEDGGLLFVSGEKNINVTYRSPEGVISRIYETSGVIKYAKSLNNEYLAILNENKEVISISLARFLVDPPASDVNDLEVAIKTFNYKSPIISIAVNNDNIIALGSVAGPIQIIFNDDNDNEKILRWHIGPAKTLHFHENFLLSGGDEKVLVIWQIDNDKTQFLPRLNGVIDKISVDVNKPDNYNLALNINGQYELLVLSAVDLVSRLSVNSIRPNLKRKLNIKNSTSIVEANPKTNHLYLPSGSFIQAFDLVKNEQLFHQTVSSVVPTGKVKSELKLMDPAVSQLKFSSDGEWMCTLDIVNNNEIENLLSQDDKNYALKFWKPASASGWELVTKIIDPHLKVQVLSVMPYQNGFITADASANLRFWKLRNKSWAVVKTLDLMKPESKSVDLAISEDNSVIVVSHDNVVYMVNSNFKLVQPLSLVESHIRSIELVGTDLIILSKTKLVSFNLVTFEFNSLMAQVAVAQGKTYLCTNNQLVALALNIQDSERCKVMLFKPNDLHPVFATIHSTYVNSIIPYNDGFLFVDNELRSGIISTNQLRLKSDESEINGTSITAAAANSSVPADEIENFSFKTFDLNSFNNIFETDNLDTLFDKIIKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEY9</accession>
    <name>G3BEY9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_126673</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEY9"/>
    <dbReference type="STRING" id="590646.G3BEY9"/>
    <dbReference type="eggNOG" id="ENOG502QW7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008109_1_0_1"/>
    <dbReference type="OrthoDB" id="5229455at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV59968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="749" mass="83581" checksum="58B4B659E560146C" modified="2011-11-16" version="1">MAGTTRNNTKSTGIRRSRTGCHNCKRLKIKCDEAKPKCSYCVKTESTCDYSIKLTWGGRPYKDANKRQNGHFDTYRESPQLSDFITKSESQTPLDIESPPSFNTPGGISILSPQQVFIQTGLGSSMGTSHPDSQFGHPNGIEHQSESHPPPQKKDSLSSLLLNMPDLSTGIESLSNALEKVVDGGGQFGLHNSEIFNRFLSSNIDDITGSNFMIPPEPHEDVVKAVDAPSSDDEFLMNYANDLAKVEAYFPKQKHNLLYSSSSGNILSAFSRNSSPKVQELEDDDSISIPPSLVSLPELLNQVPYYKQLMHFWVNVAAENLSAAPSHIYKDNPFKVLLPQMAMEYPAILTSILAFAATSMASIAGNKPPTEIVDQLVARSCAMLLKMLKDKDEATSDGTLATVLLLSCYESLVGDNFEKHRAHALGARQIIMARRLPIAPKPVEESPTDSPDSASSKDSTFVNSESDIAFFLMRWFVYIDVIGALSATRGAQYYLNQPDGDHAITDSLNSVYPQNPDTETIDPKKDIDYMLGFDVKFLTHFTDIVMLIRKMNTYLEGSDQQKNNIPIDIVTRALEVKQEFSVTYANGEARRQYIIDRMSDYTHREGASEGEMSRKSKRMKNLIRQDKILRSTNKLFFNMGLLNLYRRVLRIPRESKIIQQLTHDMGQELVSTIASSSSAEVCSIFCLFCAGCDTLDDDMRQLFKTRFITLSEKGNVHATKSLQIMSRCWSTGEDWIEASKSLDIDLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF14</accession>
    <name>G3BF14_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116012</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF14"/>
    <dbReference type="HOGENOM" id="CLU_3014006_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV59985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="56" mass="6548" checksum="4F83B6B5688FE32F" modified="2011-11-16" version="1">MLESQEFEFLGFWEPISKTQTVDHFHSLCFIRSCGFLVEKVQNSKDSSNLNLTQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF68</accession>
    <name>G3BF68_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi to ER traffic protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Guided entry of tail-anchored proteins 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="11" type="ORF">CANTEDRAFT_116713</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690434.1">
        <property type="nucleotide sequence ID" value="XM_006690371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF68"/>
    <dbReference type="STRING" id="590646.G3BF68"/>
    <dbReference type="GeneID" id="18248415"/>
    <dbReference type="KEGG" id="cten:18248415"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089418_2_0_1"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="210" mass="23875" checksum="7D12E32F6E412229" modified="2011-11-16" version="1">MVSFDLYPSTLLVTVLTVLLFKKIIEVVGKKNIQDLTWRSYCQVAGKLGHSKLSEISNKSSEARKVNLQRKAVSAQDEYAKWTKLNRQHDKLLAEIDQLNQGLASEKAGVVKYLGLLISVLTTLPIWFFRLWFRKAVLFHLPPGYLPYPIERLFGLPFVVLGGVGLTVWMFSVNSVLTSLEFLIKFPFETPVEKPSPVDKSKVEEVKHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF73</accession>
    <name>G3BF73_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_109835</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF73"/>
    <dbReference type="STRING" id="590646.G3BF73"/>
    <dbReference type="GeneID" id="18246145"/>
    <dbReference type="KEGG" id="cten:18246145"/>
    <dbReference type="eggNOG" id="KOG2804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_0_1_1"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="115"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="405" mass="46761" checksum="53C7BDFBDAECBB39" modified="2011-11-16" version="1">MARSPELRKTRSQSPLTRSISVESIAPKLTSFFGKRKRLRDWGSEREDVSSHDSDSDDESSPDPKKRKVEQQKIDEAFQAREKELDEELPQELRKFRPTGYRFNLPPTDRPIRVYADGVFDLFHLGHMRQLEQAKKAFPNAQLVCGVPSDVETHKRKGLTVLTDTQRCDTLKHCKWVDEVVPNAPWCVTPEFVKEHHIDYVAHDDLPYASTDSDDIYKPIKELGMFLATQRTDGISTSDIITKIIKDYDKYLMRNFARGATRKELNVSWLKKNELDFKKHINDFRTYWVKNTANINNVSKDLYFEVREYIRGRKQDSDSAAASDSESEMSFRQSTPMAEFAAKYIGNANKDLNGKSIFANVKGWMSRDHHQESDFESDSTLVTTPKNSVKGRKLKKPVSRKKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFP6</accession>
    <name>G3BFP6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphomethylpyrimidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_111183</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFP6"/>
    <dbReference type="STRING" id="590646.G3BFP6"/>
    <dbReference type="GeneID" id="18246255"/>
    <dbReference type="KEGG" id="cten:18246255"/>
    <dbReference type="eggNOG" id="KOG2598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_2_1_1"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="349"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="64198" checksum="727F7400468C32B7" modified="2011-11-16" version="1">MVPNVEVKLRSIVPEVSHQLPVVLTIAGSDSSGGAGIEADIKTLSAFKVYGSTCITALTAQNTRGVRTVTKTPKDTLRDILDAIFEDFLTDSHSPLKAIKTGMLTLEAVEVLDEYIDKIHKHDLKVVLDPVMISTSGSQLFDEEGIKLCLGSIIKSSQLVTPNFEEALVLYRLSSGKRVVGSELCTMDLLVDFTAKLQATLGCENVLLKGGHLPWNSHTGTPFREGEDISNKVIRDVLYESKTGKTTVFESVSVESENTHGTGCTLSSAIAANIALGVNLANAVAISIDYIHRGLVNMPVKLGLGNGPLNHTISPARQVEMVVAHSSEANAGNEVVKNNTSVYEFFKTHPKVTPSWQKYTRHGFVEKVASNNLKFNQFLYFLKQDYYYLINYAQIHALAAAVAPSYYQTHEEALIIGEVVEEIEKHRKKLTKKYDIDYERDINIDVELSPGRACLEYCEYLLDIAKREDFLGIKVALAPCLHGYYEAGIYGAELRKNHDGALNALSLQEHSDIYESWLGDYTSDWYQQAHEKGIQALQDLFEKSEITQARLDELVDVFAHVTRLEVRFWDECRELSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW07</accession>
    <name>G3AW07_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101042</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW07"/>
    <dbReference type="STRING" id="590646.G3AW07"/>
    <dbReference type="GeneID" id="18245431"/>
    <dbReference type="KEGG" id="cten:18245431"/>
    <dbReference type="eggNOG" id="KOG4011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044085_0_0_1"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="111"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="267" mass="29858" checksum="7579503CF3B98C6D" modified="2011-11-16" version="1" fragment="single">MAPLKLKLKIGGTGGSSNNSGETASKSSKAPTKLPKIKLNVPKPPKVTNPNKIQKLKISLGPKKTHQLDAIGIEGVTSQVKRVPKVRIKPTRVPGEGYDSETPDMEDDPLIENGIIIRFLNDINLDHVHNAVGANDFSGINVKWLTKEKALVNVKGSIYSARLVDLPTISEVFKTIDKKNIFKILDLCQMLLVIKPVTPNDLNLETDFEVPSKSHYKHPLYNISPGHEIKETRPVLRDGLTQPFEDVYRRFRPRKINHRVMNDIEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW71</accession>
    <name>G3AW71_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112194</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW71"/>
    <dbReference type="HOGENOM" id="CLU_1895927_0_0_1"/>
    <dbReference type="OrthoDB" id="10629970at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="134" mass="15398" checksum="65E46BED4AF0926F" modified="2011-11-16" version="1">MSTVKEPYYLDTYSTSVKSFTLPFIPKSDPFKTNSNVHRTRSLCKNDGPTPESDVQYGLNRSNSLEPYFKPSLKVDFNMYENAIVDDDDDVYDDDDDYVYAFKVDSGPIHGLPPVEASTVRDDYDNNTKFDFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWB1</accession>
    <name>G3AWB1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_117443</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWB1"/>
    <dbReference type="STRING" id="590646.G3AWB1"/>
    <dbReference type="GeneID" id="18248572"/>
    <dbReference type="KEGG" id="cten:18248572"/>
    <dbReference type="eggNOG" id="KOG0436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_9_0_1"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000002">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="14"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="428"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV66501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="566" mass="65082" checksum="8624B6DE244FCC0E" modified="2011-11-16" version="1">MFKSFIRHTSTKPFYVTTPIFYVNASPHLGHLYSMLLADVRSRWHKLDPNHQAFLTTGTDEHGLKIQNVAEKQGIPPKQLVDMVSTNFKTLASKLNINYDRFIRTTDSDHIAAVTHFWNIMIQKDLVYKGQHSGWYSVSDETFYPDSHIEEVERDGKKVMISSETKNEVFHHTETNYFFRLAQFKDQLVSFLEANPDWIMPSGKYQELLTELRSEPLSDLSVSRPSSRLKWGIAVPGDDSQNMYVWFDALVNYVTSCGFPDTFELKNGQYQSRGSNPWPATHVIGKDIIRFHCIYWPIFLMAAGVELPKQVLVHSHWLSEGFKMSKSLGNVVDPMATCDYYGEDSLRFFLMEHSSISSDSNYSEKYFNFTRDNLIGKYANIVTRCGGASFNIEQAVVDNNNGCFADIDEFIRSNSLNKDKVEMIITLKNQLLDKLTSLPAIMDESMQRFENRKAIQEWWSVLELTNSFLQQSEPWVYNKPLKEDPSNEKLRLVQSYGILLACESVRICSILISPVIPTLSGKLLDRLGVDAGERNTDYLVPFERISYGKYANGKHELPIQRLPKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWD1</accession>
    <name>G3AWD1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 zinc finger protein Ribonuc_L-PSP Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_117474</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWD1"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006466_2_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="819" mass="93614" checksum="6E20C73C880C6E66" modified="2011-11-16" version="1">MTAPAEETPPRQRKRTRIYGSFACDFPDCSKSFTRHDHLLRHKRNHNPQNRLPCTWPGCQLMFNRSDVRERHMKRHSQSLPYNKESLPYDKQNIPYDKQSLSYNNTSLASTKHPDIIKENQTNLQNTNAGRTVTTNGTGINSQINTMSSQDVHSSNNGVPGILPYTGKNLSPSDLIEWLFHDDTSHDGSHDGSHDTHDGPVFSHHSPIDFRQSFDFPTGVSPMSLLESMFAVSPDFPHSNTRRSIDTNVRDRLVALVPALNTNPDFGVPQIERYLDIYWLIFHPQYPILHRPSFDNTTAPPLLLLAMIMTGAGLSACTGMPEPLLENPHRLADDIAGPLRWLIFASPACMPPATVWVIQSLLLLETYEITSTSRALHERAYLHHGTKVQLLRRSPILGGDPLKDDVDDEAYPNHVWKKWIEVESMKRATLMAFYLDTVNATVYGHVIILYAHQIKLSLPCEDDLWEFDNTKQKPDSLVSEKPPKFLVALRKLLHRQKVKTSAFGRKILLAGLLTIMFQMQQKDLQLSFLEWNQMKDSWNETISLAIDVWRTDICSKGCCNTENSLRFSEEDKQRLPPMLRIDDKRCKFSLYHISQIYMRITHYDYIIYAGAPSRMNVIAGTSAYAVVEKRVSNWAKSANGRISVVHAYLFLCEMLLSPDNEDITYSYDPNLDPFLHRKNILVSAVLVVFAYTFVLEGPENDIYDSITGDYYPDKEDGYAYLKRIRRELSSKVTRFHTNSASTSSQFHENIKLFANAIPTIPNKNHTVGLLKIFSKTFQNCRWEVGIEYGKLFQNCMARGLGRKKITCDDMYTGNTTQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWE3</accession>
    <name>G3AWE3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_91685</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWE3"/>
    <dbReference type="STRING" id="590646.G3AWE3"/>
    <dbReference type="GeneID" id="18250100"/>
    <dbReference type="KEGG" id="cten:18250100"/>
    <dbReference type="eggNOG" id="KOG2759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025709_4_0_1"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="348"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="471" mass="53682" checksum="4BE9D63922EDE213" modified="2011-11-16" version="1">MTIESSFAIDSQFLADQKKVIRERIIPWEGLSRANIISEDEANYIKILEKQSTENKNSTIANQVKLYASTLLNLLNKLDNNPRDDVLKSLLCLVNDLLIDLPEFGDELIKLTDVDAALPFEPFVKYLGHTDSVIKTLSLYNLTVLLVKASATKAIDDEIVSKAFREHTVLIHGNDVNYKFITIQLLQYLLIIKPFKLVYLKTDFAKNFKSLASIIDYSVANENLINSSNLQLIYNTLLNIWILSFNPKINKLIYQQNPQLIGDLLTLSKDSIKIKIIRISVSILKNFVSIVDSSSDKFKIIKVILHNDGLSLITNLKSRKISSNGSDEELTGDLNYLFDELNDIVKNKLTSFDEYLTELETPNLLSWSSPTHKSSEFWLENSNQFKENNFKLVKKIFEVLGTNSDNTNLQKVILLSDLQYLIGNLGQDLVDFINGNKDYKLLIMNLLDTNNDNELKYQSLKTIQLLVGHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWR9</accession>
    <name>G3AWR9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_117679</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWR9"/>
    <dbReference type="STRING" id="590646.G3AWR9"/>
    <dbReference type="eggNOG" id="KOG0526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000098">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="370"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="546" mass="61547" checksum="44B1ACA27AAC7F55" modified="2011-11-16" version="1">MPNVDFERIYLNQSRTNGRMRIADSGLGWKASSTGANGAQTNQPFLLPSEEILSFMWSRGSRGYELRVQTKNKGVVSLDGFDSENFAELKQELQRNFQMSLEHKEHSLRGWNWGKTDLARNELIFSINGKPSFEIPYSEINNSNLTGKNEVAVELNLETSASKAGDELVEMRFYVPGVVENETKTVTKVKNEEGEEKEHEEAEIEEISAASVFYEQLKDNANIGQVAGEAIVSFSDVLFLTPRGRYDIDMYPTSLRLRGKTYDYKIQYKQIERIFSLPKPDETHHLVVLQIDPPLRQGQTRYPFLVLQFAREEEIEVELNLSEEDYKSKYEGKLKKRYDAETHLVMSHCFKGLTERRLIAPGSFQSRFLQPGVACNLKASEGYLYPLDRCFLFVTKPTVYIPFSEVSNIVMSRTGTGVSASRTFDLEINLRSSNQSHVFGSIDREEQASIESYCVQKGLRIKNEEKVAKAMMAKALNEAADDDEDDDDADIDMGSAGEEESEEDGDFNSGSDSDPAEEFDSDASLSGSDDENMSEGGEPAKKKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXE2</accession>
    <name>G3AXE2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_112102</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683610.1">
        <property type="nucleotide sequence ID" value="XM_006683547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXE2"/>
    <dbReference type="STRING" id="590646.G3AXE2"/>
    <dbReference type="GeneID" id="18246354"/>
    <dbReference type="KEGG" id="cten:18246354"/>
    <dbReference type="eggNOG" id="ENOG502RQI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029376_0_0_1"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="509" mass="57818" checksum="FA792F1C0ECFA9EB" modified="2011-11-16" version="1">MSGDTDLRPYYNPDTFDAGYSVIYKPGVGLVDPHTGASVTSSIHPILNNSSTGRYNPGANIGLRGMAAMSKDSQEKDYFNDLEFSEYFDLNNLGALLRNLFWNFLKNYVKVIVLQPLEITRLVLQVGTFDFQKKPVQTAKQPLPRLMDESSELTPQVSQQFSDDDSDFEVNYFQSLEKSKSSLTPEVGSPRKSRAKSPSKSKKLSKKKHKIQPVSKHTVDIIAAIVSKDGPNALFRGLNAQFIHQSLSHTIEAWITGFLSPFLGIPDPFFLDLTHSTEPLRSLCLSVSACVLTGIILIPLDLVKVRLMITQFNKPYNKDADADLEMGEQLHTPQSTRSIRESLRNYPVELLVRPPMSISFLTVLHQFATSIFRKSAPYLLFIRFNIDQYSSPSWYTIFNLLLSIMEFFIKLPVENLLRKQQVSFLLQPKSLKLDPMRVVTIDNPDRDLIVDFNHEWKHTDIKDNKFKSTWRSLVNLGLFNGWRVGVLNIIGFWGYKIVQSGASIQEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXE3</accession>
    <name>G3AXE3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_112103</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683611.1">
        <property type="nucleotide sequence ID" value="XM_006683548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXE3"/>
    <dbReference type="STRING" id="590646.G3AXE3"/>
    <dbReference type="GeneID" id="18246355"/>
    <dbReference type="KEGG" id="cten:18246355"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061883_0_2_1"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF224">
        <property type="entry name" value="HL02043P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="138"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="230" mass="26538" checksum="CD4989B17A98E903" modified="2011-11-16" version="1">MSIDPFTDVEEDAWSQIRVLDSIILNADIITEELKLDFSNGFQELEEIITDLNEALNVSQANPQQFQLTVADIENRHGVLEKLEKKKRSLSSIWKEKTNDSKRSRPVTAMSNRISQDGSNPFTDQHKIDGEFEQFQQQEMIRDQDLQLDTIHETMRNLNQQAMIMGSELEDQGMMLDELDTNLDRVDNRLQRGLKRVNWIIEKNKERGSDWCIGILVVALVVLLILLIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXH8</accession>
    <name>G3AXH8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5-oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_132639</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AXH8"/>
    <dbReference type="GeneID" id="18249637"/>
    <dbReference type="KEGG" id="cten:18249637"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_0_1"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF26">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="241"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="562"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="742"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1310" mass="141827" checksum="F9D60057166137BB" modified="2011-11-16" version="1">MTVENRISISIDRGGTFTDVLAIIPGKEDYVFKLLSVDPSNYKDANIEGIRRVLEHAHGVKIPRNVPLDTSTIESIKLGTTVATNALLERKGVPTALITTEGFKDILHIGNQSRPDLFALNIVKPEALYKKVVEVEERVTLPAFTEDAKGYDAKDLLNGQTYVLGETKEVVKIIKPLNVDKTRAQLLELKQQGIVSVAVVLIHGYNYQEHEKQIGALANELGFVNVTLSHKVLPMIKAVNRGQSACVDAYLTPIVQEYIKGLISGFEEGFEKHTRVEFMMSDGGLCDYKKFTGLKSLLSGPAGGVVGQARTCFDIDDGTPTIGFDMGGTSTDVSRYAGLAFEHVFETTTAGIKLAAPQLDINTVAAGGSSILSYRNGLYQVGPESASAHPGPVCYRKNGPNLTITDANLMCGRILPEFFPKIFGETEDQPLDKEAVIKRFTEMAEVINADNPNMTPKTPYEIALGFLDVANVAMAKPIRQLTENKGFDVTKHNLASFGGAGGQHATSIARALKMKRIVIHKYSSILSAYGIALSDVVHEAQEPSLTVYNSSSKDYLLDRCTALKEKVALELAEQGISDVDYQVFFNMGYKGSDSKLMILQSDKDFLTSFYDTHQREFSFNNFKKEVIVNDIRVRGSGSVNRIQERSPFKDLAEITQVPVADGLEKILSPVYFNGGFQESKVYLLGDLPVGSQIKGPALVLDSTQTLLVDPNSVLTVLPRHVVVDLDYNSIDTNKNLSIDAVDPVQLSVFSHRFMSIAESMCTTLQKISVSANIKERLDFSCALFDECGNLVANAPSVPVHLCAMSFAVKYQINYWGSDLKPGDILATNHPKAMGTHLPDITIISPVFIEGKIRFFVGSRAHHAEIGGTVAGSMDSSATSLDSEGAKFVAWKVVQNGVFDDAGVQKYFVDDLKKIPGSSPSRKLSDNISDLKAAIAANQKGINLLSDVFNEYDTEYVLFYMRSIKDTTEAAVRSFLKKLAKQKGSKPLTAVDYMDDGARIQLKITIDEAKGSAVFDFTGTAEETFNCFNAPSSVTSSCIAYCMRCHITEGDLPLNEGMLSPIEVIIPPGTVLNPSVTAAVSGGNGITSQKIADVIMKALGTVAASYGCMNCITFGQGGYDKETGEMIPGFGFVETIGGGSGAGNGFHGFSGTQCNMTNTLMTDPEVLEQRYPVVLKQFRVREGSAGIGKWNGGEGLIRELQFTSACHASILTQRRVFRPYGMAGGGEGGRGENRLGKIRADGKTIDWKHVGPTAEIEIDIGDIIKISTPGGGGYGVANEESEPSTSVVKPSTVVTAGGSFYQYREAMNSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXI4</accession>
    <name>G3AXI4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_96445</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683648.1">
        <property type="nucleotide sequence ID" value="XM_006683585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXI4"/>
    <dbReference type="STRING" id="590646.G3AXI4"/>
    <dbReference type="GeneID" id="18250609"/>
    <dbReference type="KEGG" id="cten:18250609"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="299" mass="33331" checksum="0A25D4F1DC220463" modified="2011-11-16" version="1">MTIESAQFKRLIRFVSSDGNTYFGDAILPEGSIDVYQCKTAFKINGDIFGDYQLTEEILTVTKLLSPLAAEQVPAIRCVGMNYIKHAIELKMQIPKYPVVFFKPTSAIVGPEDPILVPSACQIHGAKIDYEVEMVIVIGKTGRDIEEKDAQDYILGYTIGNDVSQRTWQMDRGGTQFGVGKMFDTFAPIGPAIISKHELTDTSNLRIYSQVNGEQRQDSNTQDMIFDVNKVVSFMSMGTTLKPGDIIFTGTPSGVAVGLEHTPYLVDGDEIFFHIDQIGNLKTKVEFEKPNQKILEYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXJ1</accession>
    <name>G3AXJ1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112125</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683655.1">
        <property type="nucleotide sequence ID" value="XM_006683592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXJ1"/>
    <dbReference type="STRING" id="590646.G3AXJ1"/>
    <dbReference type="GeneID" id="18246366"/>
    <dbReference type="KEGG" id="cten:18246366"/>
    <dbReference type="eggNOG" id="ENOG502QUGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024117_3_1_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="298" mass="34158" checksum="4846D04757425713" modified="2011-11-16" version="1">MVNYKTWMKEVNDDTSIGKLSIPGTHNSAACHTALPSVQCQGESVTDQLKHGVRFLDIRCGKLFLKEGDEAKDLQVIHGKFPVKIPFPEKLTDVLEEVYDFVGDNDSETVIVSLKQEGTDDWNNDDDEFANCIWDRYINKNKDKWYLENNIPRLQDARGKVILFRRFGLKNQDKENSFGFDAHTWKYNTTNDDRGTFAVQDFCELEDASAIEKKVDYVADFAKNAIEYNSSNSDPKLFVNFGSGANFFNTECWPEKVAIKMSDGHIDKHFGKGNGVIVLDYVERDDWKLVKKLIDHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXP6</accession>
    <name>G3AXP6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_112536</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684697.1">
        <property type="nucleotide sequence ID" value="XM_006684634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXP6"/>
    <dbReference type="STRING" id="590646.G3AXP6"/>
    <dbReference type="GeneID" id="18246566"/>
    <dbReference type="KEGG" id="cten:18246566"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="378" mass="43015" checksum="CE8317FF01FDD535" modified="2011-11-16" version="1">MKVEPVRTQAFMDVSIGGKPAGRIVVELFEDMAPLAALNFINLCTNTDGYTYKHNYFHRVIKNFMIQAGDVVNCVDGKPYTDDSVGTSNISTVNGEKLFPLENQQEPLDASFKLCTANANAAANGSQFFITTHPQSHLNGKHTVFGRVVHGKWAVRQIEQVNTNPNNCPTENEKVVIEDCGIWEESMSVPVFNSCADTTGGDIYEEYPDDDEQIDKESSESVFNASTIIKESGTLLLKQGRKQDALFKYHKCLRYVMEYIPDDEQEPQWYEKYYDLRKKLYLNMALVYLQVGEPTRAIDFASYLLDLKASTAERAKAHYRRGLAYVAKNQFSEAVNDFTEASKYVPNDEAIKRELKRAEDSIEKKKRTEKARYAKFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXS7</accession>
    <name>G3AXS7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112553</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684260.1">
        <property type="nucleotide sequence ID" value="XM_006684197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXS7"/>
    <dbReference type="STRING" id="590646.G3AXS7"/>
    <dbReference type="GeneID" id="18246577"/>
    <dbReference type="KEGG" id="cten:18246577"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023125_0_1_1"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="138"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="415" mass="47241" checksum="2D8784207EFE603D" modified="2011-11-16" version="1">MSETNPLLNKRSPREEDIYEYEEYDEELSLSPGVKYTLYGLAGFLCVGILYVFTVFLPAYFIPEAVELDDIVKISDLGVELKPLVSTVMFNDVVDSDDFVDELDSDDFDDELDMLEADHITHYEDENAVGGSKNTVERLIMIGDIHGHYIELRHLLRKVKYNKKKDYLLVLGDFVSKGPDSQKVIEFLDKNNIDCILGNHEFYILQNYVKFHGLKFPDFIVGNSTESIPLDIHVSDAFNDDPEFLLAKKLQPEHIRYINKCSLIKKLGQVPVYSKKKSSGIFKHITTTKSSPGIAVHGGLRWDLSLEDQNPIEALEMRSLVGPYFNRSTDDPHEQFSVSWSKVWNKKQKRSSTSSVVYYGHDARRGLNLKPYSRGLDTGCDRGEQLSALVIWNEADATGGIDQIVYKEKVVQVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXX1</accession>
    <name>G3AXX1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor IIIB, Bdp1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_92039</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684289.1">
        <property type="nucleotide sequence ID" value="XM_006684226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXX1"/>
    <dbReference type="STRING" id="590646.G3AXX1"/>
    <dbReference type="GeneID" id="18250145"/>
    <dbReference type="KEGG" id="cten:18250145"/>
    <dbReference type="eggNOG" id="KOG2009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021041_0_0_1"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017174">
        <property type="entry name" value="Bdp1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037327">
        <property type="entry name" value="TFIIIB_Bdp1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="474"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="630" mass="71919" checksum="961FC5E877615F73" modified="2011-11-16" version="1">MSSIVKKAQTSFTPKFKKNVNRKRQRTSDADTLVTPQTTQQSQEDSIPDAASPDKQAPSVTPEPSQVSFYSSSKSDKVAEEDVDPHDATRKISISEEVITNEGEEDEEDYGDNDIFKKPQEDLTRRKSSMSQRRLSGISIRKSGSRSASISISVTPRGSFGEYNDKMPAPIPIEIPVTKNKRRRSSVIKPSKRVSISDGRSKSVGEGGEVRDIEEEDEDDANEEMLLVDGVETRDTVVEYNVDDEISRDELYEHGEYLIFAVNPITSILSQFRTGPLEGKLEGHDDRDYPLAPETVSMKISSIKQIPKHLRKRNIGSLVNIKIDSEKMTMEDICNPSLPVGVLSHNFQLVQEAKKRTLEAQAFRRNARRYAKLNQISYEKAIEILEKQARKAEQENGTVSKKEEDTEQGVKPDPATELPSIRQTTGLKLNVNPSGKIDIDAESTVVQRGAQDLGDRQREETNPFEKPVISNTYSKRKYTDKWEPNEEQKFYDAISVWGTDFSIISTLFPHRTRKQIKAKFNNEEKRRPELVDMALNRHGKVDLEKFAAETRMKLETKAHFEEAQRQIRVENDAQKKEILKERERAMLEDAEKNRRKEIERKSGQRQPIQRLSRTKQLRQNEEVVGTLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYA8</accession>
    <name>G3AYA8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="14">Aconitase</shortName>
            <ecNumber evidence="14">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_96901</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYA8"/>
    <dbReference type="STRING" id="590646.G3AYA8"/>
    <dbReference type="GeneID" id="18250639"/>
    <dbReference type="KEGG" id="cten:18250639"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="63"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="581"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV65806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="778" mass="84588" checksum="8293C5DF23D2C1DF" modified="2011-11-16" version="1">MLSATKRSIRLNGARNLATASLTRDSQVNQNLLEDFSFIQYKKHLENVNIVKSRLNRPLTYAEKLLYGHLDDPHGQDIERGVSYLKLRPDRVACQDATAQMAILQFMSAGMPQVATPSTVHCDHLIQAQVGSVKDLARAIDLNKEVFDFLASACAKYNLGFWKPGSGIIHQIVLENYAFPGALLIGTDSHTPNAGGLGQLAIGVGGADAVDVMASLAWELKAPKIIGVKLTGRMSGWTSPKDIILKLAGITTVKGGTGAIVEYFGSGVETFSCTGMGTICNMGAEIGATTSVFPYNSSMADYLNATGRSSIASFADLYKKDFLSADEGCEYDQVIEIDLNTLEPHVNGPFTPDLATPISKMKETAIANGWPLEVKVGLIGSCTNSSYEDMTRAASIIKDAATHGLKAKSIYTVSPGSEQVRATIERDGQLKTFEDFGGVVMANACGPCIGQWDRRDIKKGDKNTIVSSFNRNFTSRNDGNPATHAFVASPEMVTAYAIAGDLGFNPIQDTLKDANGNEFKLKEPVGVGLPPRGYDKGVNTYQAPPSDRSTVQVVIDPKSDRLQKLTPFKAWDGKDAERLPILVKAVGKTTTDHISMAGPWLKYRGHLENISNNYMIGATNAENGEINNVKNHFTGVYKGIPETAADYRDAGKKWVVIGDENFGEGSSREHAALEPRFLGAFAIITKSFARIHETNLKKQGLLPLNFIDTADYDKIQPEDEISLLELNELAPGKNVHLRVYPKDGSEPWDSELSHTFNAEQIEWFKYGSALNKMASNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYC6</accession>
    <name>G3AYC6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_133241</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYC6"/>
    <dbReference type="GeneID" id="18249683"/>
    <dbReference type="KEGG" id="cten:18249683"/>
    <dbReference type="eggNOG" id="ENOG502RPVG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034119_0_0_1"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040252800" evidence="1">
        <location>
            <begin position="17"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="385" mass="43067" checksum="9BA9C52949A165B2" modified="2011-11-16" version="1">MRFFWLSLASFTCIAAVVIPSPLAVVGRRDLGEYSTSIQAIATESPQYDPSDLAKEMSTNLVNLFYANESNNWSDYCHSTSMPVVWQVAVAGKVMTNTKKPEYLDKAISALNNYRNASGGYSASMSRNGEIYTDDNAQIAWIYAQAYENTKYSKYQNENQNITDFIDGYTTRGGGILWSISGTYIASISTLEEAVAALKLYSSKKDSKYLDIAKANVNWVIDNLLENSTDFIWDGMNQDGSINEGKLTYTIGTMISSCAYLAYYGDSDRDWKAIGVQFGVQFIAGGALNNQFFTNGHINDIIERSHLLFVGIADLVAMTVPTSSYEYDAYQAFKRLVTRESRNLYDEYTSVVRNSSCPTNEYQSLLKYSSLAQVFYEVSRVVDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZB2</accession>
    <name>G3AZB2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112914</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684628.1">
        <property type="nucleotide sequence ID" value="XM_006684565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZB2"/>
    <dbReference type="STRING" id="590646.G3AZB2"/>
    <dbReference type="GeneID" id="18246733"/>
    <dbReference type="KEGG" id="cten:18246733"/>
    <dbReference type="eggNOG" id="ENOG502S70K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086433_0_0_1"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="240" mass="26330" checksum="01FF07B8619089DB" modified="2011-11-16" version="1">MFARTSSKKMAAIVAASVVYQTSSSSVLNESKRNFYEDEPSLNSAPVSDPASPLPSQKIVNGVLVESPSFLEAGIKTVRESVYNVYAGATGLVDDGYSKYHQAEQKVTSTVSQLHDKSEDLLPNSAYIAIAFLSGTILARQRSVFAKVVYPVILGVGSFRYFLPQTFGSTTGLLWQWEQQKLPEVAKQQESLVKKSEQIVTQLEKTTESSQAKVTSMVDSLRLTIKKYTGLNLDDDATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZG6</accession>
    <name>G3AZG6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bud emergence protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_102067</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZG6"/>
    <dbReference type="STRING" id="590646.G3AZG6"/>
    <dbReference type="GeneID" id="18245527"/>
    <dbReference type="KEGG" id="cten:18245527"/>
    <dbReference type="eggNOG" id="KOG4773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014957_0_1_1"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="45"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="141"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="277"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="68545" checksum="025CF48A5B84FB8A" modified="2011-11-16" version="1">MIKSFRRGKRSSSSSDSGKSHVISRITSGPQVRNGDGNASTVLHTPKLVIKALYDYLPQGPDELAFKKGDFYHVLNDNDENEENGWYEAINPMSNAKGMVPISYFEVFNRSRPNPDMDVSPSSSRILSQASKAPSSQRNSNQTLYAIVLFGFKAEREDELDIIPGENLIICAHHNYEWFIAKPINRLGGPGLVPVSYVKIVDLVNPNNVNANDDLPKVIDSFKIPSVEQWKDQTAKYQASTIPLGSISNQTPPSSSNTQYFQKDGVTPVSNRSSLSSSNTVILEASVDSYQLDHGRYQYLIVAKLGNSKVRYLYRYYQDFYDLQVKLLELFPYEAGKIENSKRIIPSIPGPLINVNDSISKLRREKLDYYLRNLIALPAHISRSEEVLRLFDVLNNGFDKEVVDPFVKQRQSKPISQKSNYQQDRLSQYSIMHNHQGTRVSTTPTSSESNFNRSSQSSVNLFNNLQDPHPSQPKALTNSSQPQLVTKAPPTASAPVPVSGSKMKVKFYYQDDIFVLLLPSGLRLIDLKSKLFKRLNLNEEPKNECDPESIRLYLKNDLDGFQEENNLTDYTFNDIQQLKLKEFEINNDDKFHEVLYDKCKLCILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZK9</accession>
    <name>G3AZK9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_91928</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZK9"/>
    <dbReference type="STRING" id="590646.G3AZK9"/>
    <dbReference type="GeneID" id="18250132"/>
    <dbReference type="KEGG" id="cten:18250132"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
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        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
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        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV65611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="376" mass="42687" checksum="091A551037CB627B" modified="2011-11-16" version="1">MGVKGLNALIKDHSPGAIKEFQLKNLFGRKIAIDASMCLYQYLIAVRQGDGQNLTNDKGEITSHLSGMFYRTLRMVENGIKPVYVFDGKPPVLKGGELEKRYLRKEEAIKKMEDAKEEGSAEDILKFEKRMVRVSREHNDEAKKLLELMGIPYINAPCEAEAQCAELARGGKVFAAASEDMDTICYSPPYLLRHLTFSEARKIPIDQIDCKTAIEGFEMDKKTFIDLCILLGCDYCETIKGVGPVTAFKLIKEHGSIDNIVKFINDNPDKTKYKLPENWPYEEARELFLNPDITPCSELSFKWKEPDLEGMIEFMVNDKGFSEDRVKSGYEKLKKGLKTGVQGRLDGFFKVVPKKEDDKKRKAKDTKTNGKKKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B019</accession>
    <name>G3B019_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113027</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685183.1">
        <property type="nucleotide sequence ID" value="XM_006685120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B019"/>
    <dbReference type="STRING" id="590646.G3B019"/>
    <dbReference type="GeneID" id="18246792"/>
    <dbReference type="KEGG" id="cten:18246792"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_1_1_1"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="394" mass="43916" checksum="3EEB65663E8709F2" modified="2011-11-16" version="1">MRLIRYLHTARSDFSHAVIGGGIVGTAIAAEFQKDGHNVLLIEKNPHLGMETTSRNSEVVHSGIYYPKHTLKSKLCIEGRNLIYNALDTGKFNSVQVAVQKCGKLVVAQDEQEAEYLHKLHKYVKEELDVKTEFLSHRQLKSRYPHISGVLALNSPTTGIISAHDYLLYHQTQLENHEGTTAFNTTVTDIEYNRGTSNYTVTCSTEDDEAFEFTADVVINSAGLHAQKVSNLLLPPERHYTPYFAKGTYFSYSPVKSLGKFTDTLIYPCPNHNIAALGTHLTFDIGGQIKFGPDLEWLDVNDANEIDYTPSHANLEAAYVAVRRYFPHLQSGELSPSYSGVRPKIASAEETKKGFVDFLIKQEEGYPGFVNLLGIESPGLTSAWAIAKYVKQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0F2</accession>
    <name>G3B0F2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_97291</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685074.1">
        <property type="nucleotide sequence ID" value="XM_006685011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0F2"/>
    <dbReference type="STRING" id="590646.G3B0F2"/>
    <dbReference type="GeneID" id="18250675"/>
    <dbReference type="KEGG" id="cten:18250675"/>
    <dbReference type="eggNOG" id="ENOG502S1P2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082765_0_0_1"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="293" mass="33684" checksum="4AD744A7CD48C7AF" modified="2011-11-16" version="1">MSMAIAPVPTKGNGIPLGMLLSLNRALKKTILSPKFYQELNDKVLTKASTIDSVLYFTCYFALLVSSILNNKTSIRRSLQDQRLKLVKLVETRFGVSLASSPNKWLNRLAVEHQLVEKPSTLGKILKNINTYVADVRIFNRLGDCIKYVPWIAGEFNAFLLPSSDTPKFTRFINLLQSLNCFVLELLENAGWLTEHDWVATGDNNWWCIFTYIWCCRVWGVYILVEIMELLRRTPVKDWNRSWKISMFKQVIQMPLVLHWSLYDGCLTPFWVGVCGCGASWWGFRDVMASLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0H0</accession>
    <name>G3B0H0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113134</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0H0"/>
    <dbReference type="eggNOG" id="ENOG502RQBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1077685_0_0_1"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="258" mass="29263" checksum="7BBB1C165CDF0C6B" modified="2011-11-16" version="1">MKLQEPLFQAFNRLGFKLFGINPFNNRVAKLVSISKLGVENSVIAILLLYRFLLNHVVQIHDKKLIQKLVITSLVLSNKLYNDQSYTFKTWINLIELSGIPNIDMKMLKQLEIFFLSCLDYKLDYKFIMEDHKFWSHLCDIDVASTQLFRSRMLDGAYQTSVAMVDSPIVTPITPQDSPSVYHSSVMGAMVMAPLLVPSGSFTFNFGNSNANTNTSKRAKVGVTTPNDYHDIYPSFNNIPIVPLMVTIMGEEVMPHCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0N8</accession>
    <name>G3B0N8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113198</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0N8"/>
    <dbReference type="GeneID" id="18246852"/>
    <dbReference type="KEGG" id="cten:18246852"/>
    <dbReference type="eggNOG" id="ENOG502T36X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794797_0_0_1"/>
    <dbReference type="OrthoDB" id="27267at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41734" checksum="8183D428373D00D2" modified="2011-11-16" version="1">MLHALSSDLVTRILNQLTIQDTYGFIASALSLTHISPLQQNAINSVVIMAYQRIYGGKLTVYSNLDQTNSPQFEKSMTLSAFQDELSTTRDSVEINTFKQTRPQYVVFVFIRQPNDYTKFVRDLNAFSELIDGKTRSREFVAYFESLLQCGLTIDGSSVVSLMTTSSLVAILKVLISISTKSNAVCEKLTTITIRFSQIGRYFVTQWCRLFSRFINVTHLDISHNFIPSDEYVFNINEPSMKDIIGTCFQWPPRLRYLNLDRNDISYLSCELLRRLPDTLEVLYLAGNQLSAIGPFSPEEHGVNHYLPNLHTISFNFNVRLTFIDPAFFAASKAILKLCCVKNCNLHQGNLPQLLQVAKQMNFTIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0R9</accession>
    <name>G3B0R9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_102554</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0R9"/>
    <dbReference type="STRING" id="590646.G3B0R9"/>
    <dbReference type="GeneID" id="18245557"/>
    <dbReference type="KEGG" id="cten:18245557"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30517" checksum="3E3FC26E98960FB2" modified="2011-11-16" version="1">MSDSRTVVVTGASSGIGLAVAKEFALNGYNVIAGARRLSSMEELKKYSITTVELDIASPESVEKLRKLVETEYDGAIKYLLNNAGQSCTSAAVEVSDDKLSKCFEVNVFGHIRVTRELAPFVIKTKGTIGFTGSVQGISETMFLGVYASSKAAIQSYASGLAFEMAPFGVKVINFVTGGVNTAMRGFNLKTVLYNEEGLEEVAKAYDSLPNKNMDAHVYAKKVVKDFEHSKLGVIHHYRGTGSTILWIAHTFFPKFVLSMLFVSAFKLSTLLKSITNKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0X0</accession>
    <name>G3B0X0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_134131</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685635.1">
        <property type="nucleotide sequence ID" value="XM_006685572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0X0"/>
    <dbReference type="STRING" id="590646.G3B0X0"/>
    <dbReference type="GeneID" id="18249773"/>
    <dbReference type="KEGG" id="cten:18249773"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024293_0_1_1"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000205">
        <property type="entry name" value="2'-5'-oligoadenylate synthase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="304"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="36690" checksum="E69D7C86DE526475" modified="2011-11-16" version="1">MSESITVNIKSSGDTKYEVTTATSSTILELKEQISAKADVPSDRQRLIYSGKVLKDTETVASYKIQSGHTIHLVKSAAKAAATGGDSSTVSTTATDSQSTPASNQSSQVPSNISAGQGAFNPLADLTGARYAGYTQLPSASMFGPDGGMNAAMPDPEQMSSMMSNPMFQESMNSLLSNPQMLDYFIQQSPQLRALGPQAREMLQSPFFRQMLSNPEMMRSMMEMGRNSMGSGAGFPEPGTGFPAPGANPTGDSTDATTTTTNTGTNPPNPFASMFGNGMPPIDPFAMFGGAGGAQPPAETDSRPPEERYASQLSQLNDMGFFDFDRNVAALRRSGGNVQGAVEYLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0Y5</accession>
    <name>G3B0Y5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_103542</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0Y5"/>
    <dbReference type="HOGENOM" id="CLU_2203162_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="108" mass="11709" checksum="D132C454E2BEEEAB" modified="2011-11-16" version="1" fragment="single">MSPSFLVISPSNLAFLSAILDKCLLKSSFNLRSWPATFPSMTSCLLISSSFRVLETSSLMSVKTGATRKAAISNNCFWVILRPSPKSMILLGSSIRLDTEPMAAAFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B118</accession>
    <name>G3B118_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantolactone reductase</fullName>
            <ecNumber evidence="4">1.1.1.358</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-dehydropantolactone reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ketopantoyl-lactone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_97676</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16719"/>
            <dbReference type="ChEBI" id="CHEBI:18395"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.358"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>isatin + NADPH + H(+) = 3-hydroxyindolin-2-one + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27539"/>
            <dbReference type="ChEBI" id="CHEBI:28536"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.1.1.358" evidence="4"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B118"/>
    <dbReference type="STRING" id="590646.G3B118"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047011">
        <property type="term" value="F:2-dehydropantolactone reductase (A-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00051098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="307" mass="34270" checksum="02A40E0C00BFDD1F" modified="2011-11-16" version="1">MTSPDNHRCTTTFKLNNGTSIPAIGLGTWKARDEESYESVIHALKSGYRHIDTAAAYANEAPVGKAIKDSGIPRSEVYVTTKLWCTRHNEPVKALKESLEKLGLKYVDLYLMHWPVPLNPQSGEKFPMLPNGKRDIVFDWSFVKTFELMQECVKLGLAKSIGVSNFSIKNLKTLLAANLEIKPVANQVELHPQLPLLELADFCKQHQIVLEAYSPLGSDGAPVLKDETIIKLAAKYQVAPSVIVFSWLVARGICGLPKSINPSRIEQNLLVIDLAPEDVETINNIHKKKSIRYINPDWDPVDVFSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B196</accession>
    <name>G3B196_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_134219</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B196"/>
    <dbReference type="eggNOG" id="ENOG502S5Z0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472505_0_0_1"/>
    <dbReference type="OrthoDB" id="8059989at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="577" mass="66243" checksum="80DA238BE006089A" modified="2011-11-16" version="1">MVEAIEDSVLSLEEKRSLVTSSPLSPYSLVSPKPFTNYSPITVNDTQFKIYCLTQEILESETTYYNSLEILLKYYIFPLNSFSTCETSTATPLKVMNSVIEDMLKLHRPLYLFYSQKNLNLTTIDSILEEIMGKIMVIVRSSYLYTEYSNIYEDVLEISKDPRSVEITTFNTLLVCLNRYLEATQPETKRHDLSFISLIQKPISRFGKYRLFIETLLKLVRSHKLEPVVLNTLNLVKEKLEIINNETIYAKEEERTKRIGIICGIQSVSYFGKPLLIGSLMGFWIEKDKIRCSTLAAVLFKSYLILSGLSFSSWFGKVKFVIPLAQCKLIENILDSTGGIFCWFPQSFKMIYEIGKCQYEIVIANITESEYSTWLSTLQTLVNFVNGPYTMDFSNLNDNCESVACVPKNTSPYNIWPEAGNAIYQKSCYYNQPMTVSICNSIFQQNTAGPNQKYYDLYKEMSRSERVRAERRIGNLWSPELPQIMFLPKIRHKSLTSFRFSPSWKTAIEEDSIKKTIMFRRSESTPNIKLFEQLCEEEPEASEFVVTVKTHISGVSRGSSIKSALAGLVKTHSKNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1A2</accession>
    <name>G3B1A2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcriptional protein SWT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_103473</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SWT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1A2"/>
    <dbReference type="eggNOG" id="KOG4689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048317_0_0_1"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000045">
        <property type="entry name" value="Transcriptional protein swt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049014">
        <property type="entry name" value="SWT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21693">
        <property type="entry name" value="SWT1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="102"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="421" mass="47992" checksum="24A3F5478AD9BF0A" modified="2011-11-16" version="1">MSLPSRFAPGGITDDDSRKIVTIGRYEKKPIEYTIKTIEEKVERAASHSTNKDIEMVPMDNYNEAQVISEYITHSRSLDEIPHDSMEVDGEFSNVTIEPNTSYLVIDTNFVLSHLKVLDDITKVSDLYRLRIIVPLTTIRELDGLKNSSRVVESEDNNTSLNGKTIGHLARWGNDWIFRQLSNVNSPVKGQSMKQKLDRTSIKDDSILDCCLFFKQNYPANLVVLLSNDKNLCLKALSNEVLTVSYRPTMSAKLIGETIYGESVSRYGKESGPVFVEKSPTPVPRVSVSNEEQTDFHSVAQKIYSEVFTLTKSAINHVMLAVFEEDIDLVSNYEPNKIQDLRDCDSTIRVFWISAFSEYLQRIDYKNSVFIVTLPTGKPELEKFIEEWSSLLQTVYRKLLNEQQNSALKTLIERWNTMISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1H1</accession>
    <name>G3B1H1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_103862</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1H1"/>
    <dbReference type="STRING" id="590646.G3B1H1"/>
    <dbReference type="GeneID" id="18245661"/>
    <dbReference type="KEGG" id="cten:18245661"/>
    <dbReference type="eggNOG" id="KOG3818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010628_1_0_1"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="336"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="621" mass="71613" checksum="212ABC4FFCD5D3C9" modified="2011-11-16" version="1">METRVHLPVKLQPSNLRPTAYRIFSKKHGLNIQTDALKVLTDVVSHKFGSEWKGAKAQLYLEDIAKIWKAQDKGLFVDGEGLNEVLKQLNNEEKTKINRVIDEENKENINEEEELQWQEFFRVINPPEQPNYTFDKQRKQFGLRGEGKLSNFRDTNIEYFNNRYSLIRDRLSRNEVFQKTNYQSISNIKSKKQSKEITLIKNIIGNNGQSFIIFGLLTKNFRGVYTIEDTTDSIELNLDQAQKMLDAFYTEGMFLTAEGLYSQFNENSPNGIFHVTHLGHPPAERRDISSEHYGNLDFLNINKENLSNLHHSSKVSKDFRKKLVRLEKQLTDHKFIILGSNIYLDDLKIMKGLRKLFSRLEKDLTEEEEEAPVSLVLTGSFVSKPISSIQSSTSSISNSESYKNNFNNLANLIAEFPTIKSKVMLVLIPGPNDPWQSTHSLGSSNLNYLPQPSIPSIFLNRLERLLPKGHLKLGWNPVRVNYLSQEIVILKDDLMSKFKRNDIILESDLNQSNELLSENVDDNIPTKLKQARCLVRTLLDQGHLQPLSKGLKLVNPIYAHSLRIEPLPSLVILNDTKFENFEVPYTGCRVVNISSFLSDNRFNYLEYYPSQKAFKFKDLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1L3</accession>
    <name>G3B1L3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation associated element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_97365</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685280.1">
        <property type="nucleotide sequence ID" value="XM_006685217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1L3"/>
    <dbReference type="STRING" id="590646.G3B1L3"/>
    <dbReference type="GeneID" id="18250682"/>
    <dbReference type="KEGG" id="cten:18250682"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055356_2_1_1"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="248" mass="28127" checksum="FA729B5764531BCF" modified="2011-11-16" version="1">MPVKTAQGTLSGEDHYEGNADANINYDDAIEYWSSVPASVNGVLGGYGEQTSVPKADIVGSSTFIRKLLSRMSVAEGEKKLTIDMGAGIGRITRDFLWKISDECDLLEPVKPFLDRMEAELQDVKQRGKLGDIYPVGMQEWEIPPHKRGKYWLIWCQWCVGQLPDEELVKFWIKCRENLMENGTMIVKENIATFEDIFDETDSSVTRTDTKFRELFVQAGFKLIASDVQKGLPKELFPVRMYCLKAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1U1</accession>
    <name>G3B1U1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_92763</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1U1"/>
    <dbReference type="STRING" id="590646.G3B1U1"/>
    <dbReference type="GeneID" id="18250227"/>
    <dbReference type="KEGG" id="cten:18250227"/>
    <dbReference type="eggNOG" id="KOG2055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011055_1_0_1"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="514"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="543" mass="61285" checksum="AC05E578348A540E" modified="2011-11-16" version="1">MSKNINSATMDLEIPPKDMEELQLEKLVFGDMENFQMNLKKTDNLLEYNTSDEELEGVDSDASKFYSGSDDENDRQDDDMFFIDDGENSNGVEGTVDMELDDSDDNESESEEDEEHAWSDSEDEKVSISLVASDKLKKLRKSTTDDYVNGKAYIKRLRTQFERIYPRPNWVEQIEEEQNGGEEGNEASDELTNNNTNALLSILKSTDKFTITKQLKLISPNKISVTRLKDGNHNRRSKSGIQSLSFHSKQPLLLTGGFDKTIRIYHIDGKSNTLVTSLHLKDSPIYSCSFSNLVTKDNKNLIYAAGRRKYMNKWDLNTGEVEKISRMYGFEKFQKSMEYFKVSPMGTFVGLTGSSGYCNILNGLSGQFLKNFKIEGTIIDFDFSHDEKIIIITNTVGEVWEFELETDKLMKRWQDNNGIGITKIKFGGPRDRWLAIGSNTGVVNLYDRLSSTPTIPFKAVENLVTTISSLQFNSDGQLLVIASRAKRDALRVVHLPSASVYSNWPTSGTPLGKVTSVTFSPNSQMLAVGNEAGKVTLWRLNHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B267</accession>
    <name>G3B267_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_120329</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B267"/>
    <dbReference type="STRING" id="590646.G3B267"/>
    <dbReference type="eggNOG" id="KOG0570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065214_0_0_1"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="219" mass="25456" checksum="1EF615589F50977A" modified="2011-11-16" version="1">MSEDLISALYPPPPLFYKYFTSENLQKLKECQSDDKPIEGELKFLVPPSQPPGTHYRGYGNIWSFEDKLPKLSEMGYTQLYEDTDDQSAGSNKITELHKLMKSLLVNFIELIGIMHINPSEFHTKIEDLKVILINMNHILNSYRPHQSRESLIMLLKQRINEKKEEINSIDTKMSDIKDKLLTLINFSDVKLIQPDVKSDTLNTDQIKEKILYKLLKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G3B288</accession>
    <name>G3B288_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_133934</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685424.1">
        <property type="nucleotide sequence ID" value="XM_006685361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B288"/>
    <dbReference type="GeneID" id="18249751"/>
    <dbReference type="KEGG" id="cten:18249751"/>
    <dbReference type="HOGENOM" id="CLU_789879_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="307" mass="34355" checksum="5278146C1F6BA496" modified="2011-11-16" version="1">MNNSAPQIKEDQANYSLSLRNLVLSQWDALVKRFVGSIMNELKGNPSDQSFQGNIRSLSDGSPIWHPATELQWESGFPTFGDLLQANGESIREKLAQVTGHNTTSAQDSFLEYLDLLNFNRLEGIALKQIYARLTNSVKAQNASLVLPYTDDGKPVTFTEEITSLESLRHPALRSLYRQYGFTGAATCVSIIQALKPIFFVHHRDAQSFSRIFARMGNDMINMINTTSDLGTVIREEMTGMEERMRTEVDGLRTMIREELPALFVHQLTVLFQHILQQLSTRALQSIENLQTAQPNANTGDDAADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2J6</accession>
    <name>G3B2J6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWR1-complex protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_92932</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2J6"/>
    <dbReference type="STRING" id="590646.G3B2J6"/>
    <dbReference type="GeneID" id="18250239"/>
    <dbReference type="KEGG" id="cten:18250239"/>
    <dbReference type="eggNOG" id="ENOG502QWM7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008595_1_0_1"/>
    <dbReference type="OrthoDB" id="4097064at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058986">
        <property type="entry name" value="Swc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26242">
        <property type="entry name" value="Swc3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="30"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Swc3 C-terminal" evidence="3">
        <location>
            <begin position="391"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Swc3 C-terminal" evidence="3">
        <location>
            <begin position="530"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="71818" checksum="46AC0130BB9542BD" modified="2011-11-16" version="1">MPPRMRRRITSAKREQIEKEEKALSKSIVRPFDVVAGLPVSYSQPPYGNYEDVLKTPLTVKDSGILYRSLMKSRTNYVGSCPMFRLYWIKQTSYAKKLMGENRLVKTEADRAPVLSADVNARDVMVKLCDAGLTLGPHFFEIRIFIAKDERSQKKDEEPVEIKEEAGKDKSEQPETENGDNSTENDSKYDGQSKNSMEVDGPNQTKSNTLESDQKHPEPASKPTTPDPSEENSLAEVSNIEDTNSQTPKNASSSPAPQLSSAVTTQIEDSQITKQSSNPSGQSKSEKPKKDKDPTDALSAENTLMVFNLNALAKVDINLHRLMKIVATGSANPNQLMTFQGYILRAREMGSPPHPFLVPNFRLDPHTPLRIRKPSKEKGTKYLKLSKQTAKEQKLTAFQEKYISDATLVFEFVENSNVRYMLPKNSICEILPSKKSSDDRDLLISFLWIHNQTEVDRYETLLEEYETAVQEREKKEREELQRQVAEEERQKQIAEGKIVEDPPEPEPELPRSRRRPPPRRGAKKQINKPPKKLVAPEEPEPRYTAVSFVIHDISTKFVSILLNSMKPEAEVRSYMKRILDRGSRSASLHLWYQVDGKLDEALAENIRVEISNEEKKMTGFSTANANAAKKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2K6</accession>
    <name>G3B2K6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Charged multivesicular body protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_120565</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2K6"/>
    <dbReference type="STRING" id="590646.G3B2K6"/>
    <dbReference type="eggNOG" id="KOG2911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021165_3_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50936" checksum="BB39D9CB177C76E4" modified="2011-11-16" version="1">MPKPLANQNYQLLKDKTSYSVSRIGALYKDFKDAKELNPEGFEANLISWLNIFKVALENDVIEASKLAIPHKKPDLSSMLVLPTIGKPLSLDVIIGELTESKSLIPVSLFLAYESNIHNYLNTTTSIFTYLYPSHWADRVSGIGRSLSNIFSANSERYVHWPFLVEFGKIFMNTINKEVKGGVYSSKIFDEGMLIDIIHKNITKNFSMLDLQILVKYLSRDTNECTTKMSKEDILVVKFDDQSPVTDEDISIAKLRFNMSQVAKRMSSIEMKIGEINHKVKEYPSDKIKNDEAIKTKVMMLLGERRSQIKAFQSCSSAYQHLQEIVLKIDDATSNISLVNALKQSSKALNQLNDQVDLEEIDLLHVEIGDQIEATDQVTDALVTVQISDEEIEDEYNALLNEQKNDEQESNELLNKLQGLHVGSEIKINEKEAKEAKDAPAKQKAQLIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2U4</accession>
    <name>G3B2U4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113538</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685570.1">
        <property type="nucleotide sequence ID" value="XM_006685507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2U4"/>
    <dbReference type="GeneID" id="18247009"/>
    <dbReference type="KEGG" id="cten:18247009"/>
    <dbReference type="eggNOG" id="ENOG502RQQZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510886_0_0_1"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59490" checksum="A2E2083631272961" modified="2011-11-16" version="1">MSEQFKFRRAETPEKIKQVCELAQEWFLTSMTPENAGSIMLESISMRKDITQVYYLEHTKTNKPVCMVQVSHRGAYYSDSPTASGPSSAPNPDTFGVKPATALMIGFVFTAQAYRKLGLANRLISAVIEYVEKELIKENISKSDKSKPDSFASMVMNNGQLDLNLANYYLGKKYAWVLYSAVGNFYERFGFKAFPVDLFKVPTSVLTDSQQRLLEALMDSSPEAKARGKHLRYLDSSKPQDRDLVSFIMQNKELEILTELNKSTFHSELTGGRKSSSSLTNITDTLAMSKLASQTEMTSISETAGATPVAQRKSSVTVLSSAKFAMKPDVDIYKATNFLSNSRLASTEGFTAENERYNHIEGAIFTNELQQKSYFILWSTLIAQFVVVGVGELQFNMFGPTTDPLGKRSDQRRRGSSFSGLNDLGGYNFQDLDILFSAACSVAKKRALEDKNSIYVAINDLPNTIPAPMLSDYFLHYLPKTHLGADSDKSLAPENQVELYASNKFVLPMLRRFGKESAEFDLDWVANGMLSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2Y5</accession>
    <name>G3B2Y5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_97782</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996520">
        <property type="protein sequence ID" value="EGV64446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2Y5"/>
    <dbReference type="STRING" id="590646.G3B2Y5"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082755_1_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="CDR ABC transporter" evidence="8">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="145" mass="15834" checksum="D271DD3F8E37E989" modified="2011-11-16" version="1">MCLNFCGVLAGPDFLPGFWIFMYRANPMTYLIQGILSAGLANTEVVCGAKELLHFDPPSGQTCGDYMSSYISTAGGNVINPSATEGCKFCTMKSTNAFLASVSSVYSERWRNFGIFIGFIAINIIGTVFCYWLARVPKGNKSKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3J1</accession>
    <name>G3B3J1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114227</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3J1"/>
    <dbReference type="GeneID" id="18247322"/>
    <dbReference type="KEGG" id="cten:18247322"/>
    <dbReference type="eggNOG" id="ENOG502RPZ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921408_0_0_1"/>
    <dbReference type="OrthoDB" id="4083114at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="303" mass="34364" checksum="890D0BDEC258E46A" modified="2011-11-16" version="1">MTSDMSDQMPGAFIEGPSHPIAPQFYTKMEDTASQANTFVDEQNLTGFLQKQTVVRKTIRQTHLMNQLDKLVYFLAVYQLVKYCHSASLVPVVCHIIVQKLLSSEQFFSTSSESDSRDFLSFINDLEILNRENDVDEASRDRIVSGIVAKVCATIYWKAVLMVAYHIGFVCYWLKPIFDSGNINIDNGTWWFVSFIGEHRPIDDWDSLGYSSKVARLGLFGLLLSDLLILFIQLVLFQAVYKQSTASPVGRSVDEVEIEILRRKTDVGGAKDPHYETEDTIPTALKVRLYETFNMSSFVPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3W1</accession>
    <name>G3B3W1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_121347</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3W1"/>
    <dbReference type="STRING" id="590646.G3B3W1"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_1_1"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51783" checksum="92171D64FEFA6DC6" modified="2011-11-16" version="1">MPVDIIHNAVVNGPEIIPGWPYIKAYGPAVLGLAAIKYYFRGSMNTWERDMHGKVYIVTGGTSGLGSELVKELATRGAQIILLVRTIEDNWLEEYVDDLRETTNNFMIYAEQCDLNSLYSVRKFATKWLDNQPPRRLDGILCCAAECLPVGKTRQVTEEGVERQIGINYLAHYHLITLLAPALRVQPGDRDVRVVMATCSSQSLGEVDLEDLLFENKRYNKNKPYLWYGTSKLLMGLFAKEFQKRCDEYERKDKLPCNIKINLVNPGMMRSPSTRRFLSMGTIWGLLLYVLLFPIWYIFFKHPYEGQQSFLFALWAPFLAKMDGGQMISECKVIRPSRKEFKDTELQAAIFDQTEELITKLEKQSAIERKKQEKKNESKKPKEQRLQEAKEKHLAQLKKKQDIHEIPASVEELDSKLGYLRQSIQPDMPLFPESVPGSSTSSKKKKSKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4B6</accession>
    <name>G3B4B6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_93450</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4B6"/>
    <dbReference type="STRING" id="590646.G3B4B6"/>
    <dbReference type="GeneID" id="18250293"/>
    <dbReference type="KEGG" id="cten:18250293"/>
    <dbReference type="eggNOG" id="KOG3438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_3_0_1"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="123" mass="13809" checksum="853E9C53CA29C2BD" modified="2011-11-16" version="1">MSTIIDEQHKDVDPDQMDQDQDIEEYDLDKIKLLPGSSEDGTAASFQIVDEDHTLGNSLRYVIMKNPEVEFVGYSIPHPSENKLNIRIQTYGSITAVEALHLGLENLSQLCGVIETKFMEALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4D0</accession>
    <name>G3B4D0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_104616</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686268.1">
        <property type="nucleotide sequence ID" value="XM_006686205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4D0"/>
    <dbReference type="STRING" id="590646.G3B4D0"/>
    <dbReference type="GeneID" id="18245736"/>
    <dbReference type="KEGG" id="cten:18245736"/>
    <dbReference type="eggNOG" id="ENOG502S263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075862_2_0_1"/>
    <dbReference type="OrthoDB" id="10053431at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="212" mass="24632" checksum="077CFD925EB55539" modified="2011-11-16" version="1">MPLFKIRQSPYQWEEVVDIVRSNKLERFARSGPDSEKYLKFKKQVVSDPQMSVFKYLLINQLQWAQSETARQLDDSQIVIKPKSTMLFVEPSDVKILKNDFPYNFAEGIHHLCVWTKFKIPVDPLSPIGDISADTRTVIERYLKKTFCEKYGIKWENLLWFKNWESLQSVKAMSHIHVIIQGVDEATVKSMLYTSGVCLTKEESSMEATVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4E4</accession>
    <name>G3B4E4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_113847</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="13"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4E4"/>
    <dbReference type="STRING" id="590646.G3B4E4"/>
    <dbReference type="GeneID" id="18247143"/>
    <dbReference type="KEGG" id="cten:18247143"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="38"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="376" mass="43540" checksum="9C213198784241C4" modified="2011-11-16" version="1">MQAQAQPSPQQPPVPAPGPGQGSQQPPRQISFNVSDHYQILEVVGEGAYGIVCSAIHKPTNQKVAIKKIEPFERSMLCLRTLREFKLLKHFNHENIISILAIQRPISYDLFNEIYLIQELMETDLHRVIRTQTLTDDHIQYFIYQTLRALKCLHSANVLHRDLKPSNLLLNSNCDLKICDFGLARSIASSEDNFGFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLTGRPLFPGRDYHNQLWLIMEVLGTPNMEDYYNIKSKRAREYIRSLPFCKKVPFQSLFAGAVTNCNPLAFDLLEKLLIFNPNKRITVDDALKHPYLKLYHDPNDEPIAEKIPEDFFDFDRKKDELTIDDIKKLLYDEIMKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4F8</accession>
    <name>G3B4F8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_93324</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686130.1">
        <property type="nucleotide sequence ID" value="XM_006686067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4F8"/>
    <dbReference type="GeneID" id="18250275"/>
    <dbReference type="KEGG" id="cten:18250275"/>
    <dbReference type="eggNOG" id="ENOG502S1EZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056292_1_0_1"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30746" checksum="F5746B4CAF4DEE61" modified="2011-11-16" version="1">MYSDPFKAVTRKLSDNVLIASAPFSIFNRLRVGARMSLFHYDGKVVVYSAFPYGSEVVRALKELTGKDEFDVSHIIVPNKEHYKAVGGFKRAFPKAKVITSEKFQTDEFEVDYRIPFSEGNKVLDEKALKAIGIKEESFLKNFQLVFLSRHRLKELVLYDKNSKFVTSADFALSFSSGRDGVEQYAEETGWPKGSNPYSGWSYLLRWCYPGNKLWVNQVNKSNMTDTEEGRAGIKAIYSLDFTKLIPCHGNILDDGKQVLTSYFSFLDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4G8</accession>
    <name>G3B4G8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_113856</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4G8"/>
    <dbReference type="STRING" id="590646.G3B4G8"/>
    <dbReference type="GeneID" id="18247148"/>
    <dbReference type="KEGG" id="cten:18247148"/>
    <dbReference type="eggNOG" id="KOG2698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_1_1"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="14">
        <location>
            <begin position="101"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="280" mass="31193" checksum="B2D4011D5844EA6F" modified="2011-11-16" version="1">MGSSNDFDKNTNGGASSTSSGSLSKAIVAPKSVLPLKRSRLSEDEIPKSATYGTPLQTRMASPCTLNPPIDSDGLSWPSQGARARLEQTEEEAKAREARIAGAVKTILHELGEDVDREGLLETPERYARAMLFFTKGYEDNIRDVIKRAVFEENHDEMVIVRDIEIYSLCEHHLVPFFGKAHIGYIPNKRVLGLSKLARLAEMYARRFQVQERLTKQIAMALSEMLKPRGVAVVIEATHMCMVSRGVQKAGSSTTTSCMLGCFREQQKTREEFLTLLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4N8</accession>
    <name>G3B4N8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_130346</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4N8"/>
    <dbReference type="STRING" id="590646.G3B4N8"/>
    <dbReference type="GeneID" id="18249442"/>
    <dbReference type="KEGG" id="cten:18249442"/>
    <dbReference type="eggNOG" id="KOG0726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_3_1"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="219"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="441" mass="49016" checksum="8F01045F08D6E1B6" modified="2011-11-16" version="1">MGQAPSGMQGGDGFNKKKDDKKKEKPKYEPPVEARFGKKRRKGPDTAIKLPSVHPSTRCRLKLLKLERIKDHLLLEEEFVTNQESLQPTEAKQAEERENLDELRGYPMSVGNLEEIIDDDHAIVSSTAGSEYYVSIMSFVDKGLLEPGCTVLLHHKTVAIVGVLQDDADPMVSVMKLDKSPTETYADIGGLEAQIQEIKEAVELPLTHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLVRQIFQVAAEHAPSIVFIDEIDAIGTKRYESSSGGEREIQRTMLELLNQLDGFDDRGDIKVIMATNKIESLDPALIRPGRIDRKILFENPDANTKKKILTIHASRMSLSKDVNLEELVTSKDDLSGADIKAMCTEAGLLALRERRMQVTAEDFKQAKERVLKNKVEENLEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B579</accession>
    <name>G3B579_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_130678</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B579"/>
    <dbReference type="GeneID" id="18249469"/>
    <dbReference type="KEGG" id="cten:18249469"/>
    <dbReference type="eggNOG" id="KOG1064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000310_0_0_1"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="1">
        <location>
            <begin position="662"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1351" mass="156058" checksum="2CF728C0B35F7BE6" modified="2011-11-16" version="1" fragment="single">MTINFIPGEVNRTENSVSHGRWKDHYIIVYGSGNNLVISSLTFKNNITDHLQTIYLESDPSSIDFNASSGFIAISVKSKVLLLKPVNEFMSRPQWSVALEVSAHSTVNCMHWAPVENELAIGTSDSIELFKIYEEYGALKYHRRWFQTQAISVTALKITFNSNKIVVQNGDYDRLLKVWSRINYGDDNTLFELTYLPHPVNDFILDFKWRFRLYSKSSKVIDESMANIKNIRNYIDTGNEDSDTLFTFSYNKVFRVWSTYESSGHNSIKCWGQLDLSDCFVNQTIVAVVLIDNYYLQKTLFRQLEGSTSELANYFKDQLYDNIDLLLVVSNLGQVALYSISNVSMIPPNSIRFERIDTMAMEFNKFSFSSITESVQSEDISSEAFKISLKPVVVPKIALFDKDDATLSLLFHNRLKNTLKLNTLNFKQLLKPNTPCIGTNLVNKFQGHDKSIRKLIKSYKSNTHSILLSISNFAKNNYIWEPLTLKKPSKRTIITKKFQIDLTLVNNDPNNFIYDALLLNDIEGSPGKRRHLVISFDKLGFLTLWDCNELEHEDKCAEVIYSEHVEDKAPKVLQLVQIEKDEYLIVSIYELDEVRCWKLKLTKENSKNIDLFPWKIQNLPPVESRYKINKIENLINDKSSSLISIIEEGGHLSNYSIKFAEIVEWVETSSFQTNIKNCSKVMGSSIINKIAFVDETGYKLQIWDSKAKLLEYEEEFNAEQGAVRDIDWCLISSPDRSCHNVLLSIGFQRFVMLYTQLRYDYTNNIPTYAPLKKIDISDYTSHEIGDSIWINNGYLVIGCGNQFFIDDRWFQLGSSGSSLINSMTRQLVRGFFEHDDDDQPSSHETSNQIFDISDIVRLLNGPLPYYHPQFLIQLMYSNQFDLAKLILVKLFQCIRSGEKIKWNLGFDLVDEILYDQQADGRHSILENAKEEDIFSTFNENLVDLLSEKLTKISLPSLTRHQQITLISLINITKLVKKYVGMLDENGLRFLIGFKLYQSSTRQSALNMRDINFALHSRNKDILVSIVEEAYDFKFTLSLVKSLGLVYWIDNYKLLEIVENIAKNEFNNERDPSGIVSLLYMALNKKNILVGLWRTTSHKERQKILAFLAHDFTQNRWQVAAMKNAFALLGKHRYLDSAYFFLLGEKVSDCCSIINSKLGDFQLSLIVSKLYHFVRSKESDTQQLIETSLLKDVIENGDKWVNSWLFWELNQKEMAIQALIKSPIDLIKSSDLNCPNNYTLNSESNKFLNEDPASILLYTSLKSKSLNYQQGSMLITPKEESEFILKICSIYDKMGCDYLALILLRNWKFDYRKFDKMNKINVNGFKEFKMDNDPPPEQIFEEPDMSAFDFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5J4</accession>
    <name>G3B5J4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_94010</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687036.1">
        <property type="nucleotide sequence ID" value="XM_006686973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5J4"/>
    <dbReference type="STRING" id="590646.G3B5J4"/>
    <dbReference type="GeneID" id="18250348"/>
    <dbReference type="KEGG" id="cten:18250348"/>
    <dbReference type="eggNOG" id="ENOG502QU9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355687_0_0_1"/>
    <dbReference type="OrthoDB" id="6347512at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="726" mass="83884" checksum="51C1FEF4E8824382" modified="2011-11-16" version="1">MIQEAPGKDHIVSHVRALKSTLSQEKDERWQLIYSLEDSVSEIGLDQEMLSEVFDIIFDVSSKSLHSNEKRYLIRKVLVPNGLHELHIALVYRIIGSIGYPRVYYQNDKKVKQKKLPSNIQNSLLQWLIASIHLFGEHGFKALHKLSPILFNLLSFEFCRPLITNLIFLCLSNTNKTFKASGNHHKPIVKNWQIQTVVDLATKFPLDPSLKVLLVLFKEIISDLDYRSFSKAQYDTLNHIKAEASVLKIPRLECMEKMVTICEKRQQEKYRNHIFEVCQTQYATFRRNITKRRRLNTSEGVHNLEMIANGSKSSKISIHDITTLEELIIQFEQIEFVNFRNILLNPSYHNKQISFNYIIFKYMIDKEDKYFSDMTFFFDQAIPRLGETEFTFLEESIVELLGYYPSFLSLDSLQKGLSLPDWGPKLLRFCGPKTNPQVLKDLVALLSKKGNYKEIFLGVAELLNVSYKMAKEECIALMNELIPFVFELIEPSELSLEHKLSLLKLLRVIKIVDEDAMKDLNANVISLPSTLYYELLFTINPIVVSEACGFLAFSKTYKNYTAQEKVVINSIVFDTLNFLWRDKAFYKDTNSQRNSKGMYFAPEFINKLPTINVFNYTSLVQLENVGNMFHNPVWSYLVSQILWEIEDKWPHISTRHPGPVTKESVASLVNNPSIEWLDTDYDSLKVQVLRGLDKLGYNGLGDLLFGSLRTIASSRDESPLIIPETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5W2</accession>
    <name>G3B5W2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114613</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5W2"/>
    <dbReference type="HOGENOM" id="CLU_2830971_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="66" mass="7147" checksum="8AAE0DD268DA25BF" modified="2011-11-16" version="1">MLAGQYDTSRDMPTVSVDNSQNDPQVHKCPKMNYSRNESANKSATSGERWGVDAGTAPADSAYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3B622</accession>
    <name>G3B622_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease III</fullName>
            <ecNumber evidence="2">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_94123</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="2"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687152.1">
        <property type="nucleotide sequence ID" value="XM_006687089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B622"/>
    <dbReference type="STRING" id="590646.G3B622"/>
    <dbReference type="GeneID" id="18250363"/>
    <dbReference type="KEGG" id="cten:18250363"/>
    <dbReference type="eggNOG" id="KOG1817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026251_1_0_1"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034963">
        <property type="term" value="P:box C/D sno(s)RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19876">
        <property type="entry name" value="DSRM_RNT1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000001">
        <property type="entry name" value="Ribonuclease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040540">
        <property type="entry name" value="RNase_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044449">
        <property type="entry name" value="Rnt1/Pac1_DSRM_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18497">
        <property type="entry name" value="RNase_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="226"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="382"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="502"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="573" mass="64249" checksum="A216E2781ECD6744" modified="2011-11-16" version="1">MNKDVYNPINDSFRTFDASHTPSENESLVDQKRHMTDSAKDEGLPYPKRSGSVNSNSNVDLSNSSGEGLTGDGSGRPSFGFVDIKKLEHSARMLQKNIKLIVDEAPNIEYLNQLIKSQRGSLDSLTYDSLRTNKLVHLAAQVKSLYEEGRLKIFDGILENDLNKSDLSEIETPNESPQDRSTAPIIPSSDSENETYVSSVPDIIRNKDEEQFAVGSTDDCPELPLIKDPHLYARVFIHKSTINNKSYLYQSELITSHNERLEFLGDSVLNNLATLIIYERYPTAPEGELSKMRSILVNNVTLAEFSIKYGFDKKLKSNINDTILRQGKQKIFADIFEAYVGALSMEDNLESGVLKSWLFKLYWSRLKVFDEEIRETEEVNKDAKSELYSLVGTAAFHPTYDVITTGDGASKPFKVSCVMGDEVLGTAVAPGLKEAGLRAAMVALKNKPMLEKYIQLRLNTDKTQSIVSHKQGSPMELETTTLVDPDIQLPLKAEKDMEFDSDARNKLYAIVSKKFNLVPEYYCEETEDRLFTAELRIDNKAIAFATDISKKKAMAKAAKLALDTPAVFWNLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B641</accession>
    <name>G3B641_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_94135</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B641"/>
    <dbReference type="STRING" id="590646.G3B641"/>
    <dbReference type="GeneID" id="18250364"/>
    <dbReference type="KEGG" id="cten:18250364"/>
    <dbReference type="eggNOG" id="KOG2167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_335858_0_0_1"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="407"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="760" mass="88062" checksum="D39BB8EFF4F93A55" modified="2011-11-16" version="1">MAISHNPVPSHLSQSRARSSSANKVSFKRLKTHSSKYRNEEHSLKQLEFSKALVHEAIDLVFNSEPLKYGYSFYYQKVEAICKYKHAEQSKLAEHLKGKIEDHFFSVVKPKVFELVHSHNLDVKQFISDLLKVYEKWESKLRLLGKLFLYLDRSYLLQHPNKKVILELGLELYVDNLLADPIEEGIITIDRYTSYLSQCLRSEVQEDLALAEVFSRMLIKLNFSQKIKLDNKIISSCLNLAKDLREVWSQDYDDYVHKTLKKISKIITFFKECGQPKDFCEKLLIQLKWVTIFFDFNEVISHCLPYMLSSENGLQLSMIYNFCELTPKEYSIDSIPIFVLHWGKIVSQQVQQEIDKESDISTGSVIVNLVKVYEKYRTVVETKFKKNEKFEFEIRHSFSRSINASRKTNSLIISHLCKYSDTFFKTKKAGITYDEFEAHFMVIFKFLNNKTDFIVNYKNQLSRRLLLSRNSSIVLEKKLVDSITSIVGENDDSIGLNVMFKDLAKSQEKYSHLKGLGNDSIEFNGLILEKKHWPEVPKQDSSVILPPSLSMLIESFNNLYKSSDEKLKNHSLDWGCYNLHQLLISCHFNGGAYELNVNLLQAIVILLFNDKDTITMDELIQQSNLDVKLLRRIILSLSDKYKILIEDGDLIRFNHSFTDKSKKLKIPLPRDRDIGSSTSNIPGDDKITTRNRDTEIRSVIVSIIKVDTKILFTDLINKAIETVSKKGPVSIQDIKSNIEFLITKEYITRDTDNVTLTYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B647</accession>
    <name>G3B647_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">CANTEDRAFT_130852</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B647"/>
    <dbReference type="STRING" id="590646.G3B647"/>
    <dbReference type="GeneID" id="18249483"/>
    <dbReference type="KEGG" id="cten:18249483"/>
    <dbReference type="eggNOG" id="ENOG502QT3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_476594_0_0_1"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="534" mass="61384" checksum="ECEBF98186347138" modified="2011-11-16" version="1">MSFNVDWNLLETESMAQWTKELLTETLNSGKRPNILASEIEIKDLNFGKIPPTFEILEIGELETDRFRGIFKINYDGDAHITLHTKVQANPLKIYSDNLTELEDFIGGSSDFIKPNFQLSNDEFSLPLDLKLSDIKISGIGIIVFSKTKGLTLVFRNDPLDSINVSSTFDMVQVLAKFLQSQIETQIRDLFRETLPTVLHKLSLKYISSNNDNFLNNLNLHNFNVNNNNEVVLFDLNNEFNNYSAKNLQKNLKLFNSRETLNLHIPKFKNVIQRSNLQKFNKKLSPNLLTSLSLINDNKVFDNNGSNGIPINFLVDKEYTDVQHIVKNISDIQSNNYYQKNVNNNMAKPKRRVIKLNRNKTSKSIDNNASNTMSVAESTLLSNYNGISQTSTMNDDDNLDVTQSEDMESEGSTCVDEQDDVLQQPRPLRLNELKQIHSHSHFHRNFDNSSPNNSNSSFLSGVGIGNNYFNFTNKEHVNPDEFKKSDDEVYNEVNEKSNNYLDVKSIKEKLNELRKLQMENHKHFYMEMPPPYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6D2</accession>
    <name>G3B6D2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_98543</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>pyruvate + H(+) = acetaldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:45484"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6D2"/>
    <dbReference type="STRING" id="590646.G3B6D2"/>
    <dbReference type="GeneID" id="18250781"/>
    <dbReference type="KEGG" id="cten:18250781"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000018">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="201"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="287"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="427"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>2</label>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV63437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="590" mass="64921" checksum="3AB94172EE48C445" modified="2011-11-16" version="1">MSEITLGRYLFERLKQLDVNTVFGLPGDFNLSLLDKIYDVEGMRWAGNANELNAAYAADGYSRIKRLGCLITTFGVGELSALNGVGGAYAEHVGLIHVVGVPSISSQAKQLLLHHTLGNGDFTVFHRMSNNISHTSAFISDINSAPGELDRCIRDAYVYQRPVYIGLPANLVDLTVPASLLDTPIDLSLKPNDPEAEQEVIDHVLNLVSQAKNPVILVDACCSRHDCKQEARRLVEITQFPVYTTPMGKGTIDEGGISGELVDNDPNLIKKMSAKLNGEHSVASRFGGVYVGTLSTPQVKEAVESADLILSLGALLSDFNTGSFSYSYRTKNVIEFHSDYTKIRQATFPGVQMKECLNHLLRRIAEACTNYVPQPVPKTKLVNTPASRDSRLTQEWLWTRVSSWFKEGDIIITETGTSAFGIVQSKFPNNTVGISQVLWGSIGFTVGATLGAVMAAEEIDPNKRVILFVGDGSLQLTVQEISTMVKWNTNPYLFVLNNDGYTIERLIHGENASYNDIQPWDNLGLLPLFNAKNYETVRVSTIGEAEDLFTSKAFAKNDKIRMVEVMLPRMDASRNLVLQAQYSAQANAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6I9</accession>
    <name>G3B6I9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTEDRAFT_106736</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6I9"/>
    <dbReference type="STRING" id="590646.G3B6I9"/>
    <dbReference type="GeneID" id="18245913"/>
    <dbReference type="KEGG" id="cten:18245913"/>
    <dbReference type="eggNOG" id="KOG0317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041707_2_0_1"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="270"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV63482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="320" mass="36649" checksum="F923F3C8027D77E6" modified="2011-11-16" version="1">MSSPSSIQQNGNALPFANSATIVRANQKDAYFESSLRSQIQDAFQIFKGQRFINKYPEEITVATKSMYLILTTLAGYRTLGEEYVDLLYINRSGKRFPGLFRRLGFIVSYALAPYIISRIVKKFKLYSSENERNKVKKWFIDVFSSYTSVLDTMMNLHVAMFYFQGSYYSLSKRLFGMRYIFGHNKDLNKMAKNSNYSLLGLIILLQFVVKGLIKFKAYTDQTNLDSSIIVDHEDDGTYKRISQIKVSANEVDLADDSQLPYIPEASRNCILCLSPMVNPSAANCGHLFCWECIVDWVRENPECPLCRTSCVEQNLLPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6P3</accession>
    <name>G3B6P3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_130547</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6P3"/>
    <dbReference type="STRING" id="590646.G3B6P3"/>
    <dbReference type="GeneID" id="18249454"/>
    <dbReference type="KEGG" id="cten:18249454"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665906_0_0_1"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000371">
        <property type="entry name" value="Methyltransferase OMS1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 12" evidence="11">
        <location>
            <begin position="255"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="449" mass="52435" checksum="4EF17587ED7695C6" modified="2011-11-16" version="1">MFAATSKRSILSLGSGGIYSRGVIIPLNVRALNPFPVTSKQIQHQKKIDNLPKWRQWAIYLNSQEFKRSATVYYVGGFVVLCVAFYFYMRDRYYEDRQIEHIKKKYSVDPASLSEYEYLKLKANSNEKLRPREEKKYRLYQMMRKEFRRKNMLSKDVMFEPTPESLDQWYQQQARIGTKPIPEIEGQHEAVEVDSKEKVPLSNHDNPHIANPEDTTAFFEAKAADYDNEIKWEERAVLMGKRRKWLMKQLKGDTLEVACGTGRNIPYFEPAAVDSITFLDSSSKMMELTEEKFRQKHPRFKKAAFTVGKAEDLVELTKGNDDIKYDTIVEAFGLCSHEDPVKALRSMGQLLKPGGRIVLLEHGRGTWDFINNHLDFRSDKRMQTWACRWNLDIGELVDEAGLDVTYEKRVHFGTTWMLICKRPEDSISIDEKPFYNKLFGKDFEPIKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6S5</accession>
    <name>G3B6S5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="10 13">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_122668</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="10 13"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6S5"/>
    <dbReference type="STRING" id="590646.G3B6S5"/>
    <dbReference type="eggNOG" id="KOG2015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_13_1_1"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="14">
        <location>
            <begin position="331"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="428" mass="47715" checksum="5A89EE93C3E02AFB" modified="2011-11-16" version="1">MNPGIDSLLRTIGPYNGAPNEYNYEFAKQQLRSSKILVIGAGGLGCEILKNLALTGFTDIHIIDMDSIDLSNLNRQFLFRKEDINKSKAEVAARFVKSRVKNRFLKIVPYYGRIQDKPVEYYQQFSCIICGLDSVEARRWINATVVAMVGPAMENLVPIIDGGTEGFRGQSRVIIPTVTSCYECTLHMLTPKVTYPVCTIANTPRLPEHCIEWASELAWGQKFSVKFDADNEQHVDWVFEQAQARGRQFHIGGITRSLTLGVVKSIIPSIASTNAIIAASCCNEAFKILTDNNGHLDNYMMYSGDDSVFTYTFEAAKNPGCPVCGTQTKTVRCQNWWTLETFISEMRTMPELQVKNPSLSTAGTKLYFAAPPSLYEATKQNLCKRVKDLVSEDDEIAITDSSLPISLRVKLEFEGPESEPANIDVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6U6</accession>
    <name>G3B6U6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_130578</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6U6"/>
    <dbReference type="STRING" id="590646.G3B6U6"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_126_4_1"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000707">
        <property type="entry name" value="Chitin synthase regulatory factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="68581" checksum="BEA36F18C12350B4" modified="2011-11-16" version="1">MSSHPYRQRVPQSEASVSSGSESSSSQYNTPQNLNLHQFRSHPQSQSIHEIASSGSGPSTLGLSDFSTGMGSPNSKPLHDSPHFNGGNRVPYPLNSSDFTTATATPPPVFANDLASPPSNPLSATSSVTNLNINNSNLDSYVTHSKSENSLATPKFNQAQHSRSVSSTSSFFERSDNISLVDFNQSLITSYLGDNSSQLLPRIKTIELYRKNAKKSNDPMVLFQFAQYMLQTALLLDTDAHNSGPTSVENSPKRGPADGTKESSHKHEKSKSGNSFDLSKLDDNSVNDKRLRIALLKEAVIYLRKLADKGYVDAQYLLGDACSSGALGKVDNKEAFVLFQAAAKHGHVESAFRTSYCYEEGLGTGRDARKAIEYLKMAASKNHAAAMYKLGVYSFYGRMGLSQTDVNVKKMGIKWLSRASNVATELIAAAPYELGKIYFHGFKDIVITDKKYALELYSQAAALGHVESSALLGHFYEVGEIVPQDSNLSIHYYTQAALGGDPNSMLAMCAWYLVGNDPFLPKDENESFEWAKRAAMCNLAKGQFALANFYDKGIGCDKNASEAQKWYIKAGENGDEKAIGRITDKELAAKLQKAFKKKKPDTQSVPSIASNLNFDSKSVAQEKDCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B701</accession>
    <name>G3B701_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Casein kinase II subunit alpha</fullName>
            <shortName evidence="11">CK II alpha</shortName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_114374</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Phosphorylates YTA7 during S-phase to promote transcription of histones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B701"/>
    <dbReference type="STRING" id="590646.G3B701"/>
    <dbReference type="GeneID" id="18247394"/>
    <dbReference type="KEGG" id="cten:18247394"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="35"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="326" mass="38748" checksum="90615F8D4AA38BE4" modified="2011-11-16" version="1">MSSVSRVYTDALSTKPQGFWDYENVVLKWNSQDKYEIIKKLGRGKYSEVFLGVELPQGSKVVIKVLKPVKRKKIKREISILQNLVDGPNVIRLLDIVREPQSKTPALVFEHVNNIDFRTLYPTFTDYDIRYYMFELLKALDYCHSMGIMHRDVKPHNVMIDYDTKTLRLIDWGLAEYYHPGTEYNARVASRYFKGPELLVDFRYYDYSLDLWSYGCMFASMVFKKEPFFHGKSNTDQLVQIVRVLGSDDLNKYLRKYNLRLTEEYEDLGYYSRRPWKRFINESNQPLVSDEFLDLIDKLLRYDHQERLTAQEAMDHPYFDPVRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B746</accession>
    <name>G3B746_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114406</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B746"/>
    <dbReference type="STRING" id="590646.G3B746"/>
    <dbReference type="GeneID" id="18247412"/>
    <dbReference type="KEGG" id="cten:18247412"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000121">
        <property type="term" value="F:sn-glycerol 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006114">
        <property type="term" value="P:glycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="254" mass="27751" checksum="CED83C026DC3503B" modified="2011-11-16" version="1">MTIQNQPAIFYVNAALFDCDGTLVNSTGAISEFWRDFGKTRPHVNPDEIIRTSHGCRTFDVIAKWSPEDANVAQVTAWEGAIPDSFGQYAKPIPGAVELVKSFDDFSKQQTADGKQRWAIVTSGTLPLATKWLKLMSITQPDCFITAEKVTKGKPHPQGYQNARNTLGFEDAAAKVVVFEDAPAGITAGKGAGAMIVGICSTYDPEKVRKSGADIVVDDLSSFKIDSYNPATNEFKVVVSEYHYANEEYLQEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7A6</accession>
    <name>G3B7A6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Na+/H+ antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_124503</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7A6"/>
    <dbReference type="STRING" id="590646.G3B7A6"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_0_1_1"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="26"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="463"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="779"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="481"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="635"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV61610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="93005" checksum="E0FFC638F070C7F8" modified="2011-11-16" version="1">MVWSQLELEDSHIAYACVGVFCTLFSLVSLFVKEKLYIGEATVASIAGLILGPHCLNWFDPLSWGESEVITLEISRIVLCVQIVAVAVELPKKYMKKHWLSVAILLLPVMTAGWLTVGLFVWVLIPHFSFSEALLVSACVTATDPVLAAAVVGKGKFAERVPGHLRNLLSAESGCNDGMAFPFIFLSLNLLIHPGNAGEIAKDWILNTILYQCVFGCILGGVLGYALRKLVALAERRNIIDRESFLAFFVFLAFNSAGFGSILGVDDLLVSFAAGTAFGWNGDFAKKTEESHVSTVIDLIINLAFFVYFGAIIPWEEFNNAALGLNVWRLVVLAFVIIFLRRLPAVVALKPFTPDIKSWREAIFCGHFGPIGVGAIFAVILARKDLEEHYIHESSLLDTELGEEVPYHQLLNTLWPITNFIVITSIVVHGSSVAVLTLGKRLNRMAITMTFTNTTANEESPNWLSRLQKLERSTTSFSLHRVDSDATTLGPSGLSEDDTERLRHTETIETSGIKYRPAGGARRKKQRRKRKNRPRPPNQFLQLGKPSTTLTSDHTDKLDDDEDADEEFQPTTSESSPQSKEHHNVEATAFQEGSNIVIEDTDGEVIESLAIKQGKQHGQRENGTDITSLHSMESLQRHMTQLSSASDESSSQVSKSENSQMPGIMRTITGDSRKAYYKRDDPSHRKVYAHQIDDVLLIENEDGDIIRKYKVSRHHAKSESNRSRSTSYVDKALSLVGIKKSAPISEEPDLEKSEQFITPEYDSGAPELQNRKVEQQVENHLHKVLSNKRKNSAVIPIPEIHDDDDDLEETEVERTRRLAALGQLSANRDEDDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7H4</accession>
    <name>G3B7H4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_115735</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7H4"/>
    <dbReference type="STRING" id="590646.G3B7H4"/>
    <dbReference type="GeneID" id="18247993"/>
    <dbReference type="KEGG" id="cten:18247993"/>
    <dbReference type="eggNOG" id="ENOG502QPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_0_1_1"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833538" description="Glucan 1,3-beta-glucosidase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="14">
        <location>
            <begin position="83"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV62277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="416" mass="47547" checksum="60CDD8AC145A97B1" modified="2011-11-16" version="1">MLLLYVLLITIQLVAAIPLVTKRGLAFDYQNDKLQGVNLGGWFVLEPFITPSLFDAFGDNSNTPVDEYNYCSTLGKDECLSRLTDHWSSWYTEDDFKAIKDAGLNAVRIPIGYWAFKMYDYDPYVSGQQDYLDKALEWCRNQGLYAWIDLHGAPGSQNGFDNSGWRDHLEFQSNEYNQALTLDVLKIIMDKYAVDDYLDVVIGIELLNEPLGNSLDLDELKSYLTQGYTLARNNGIQAVVIHDAFEASGYWDDFLTVDNGDYWNVVVDHHHYQVFSAGELERDINTHISTACALGTQHLSESHWNIVGEWSGALTDCARWLNGAERGARWSGDYDSSPYLGSCDPYTSFSNWPDDYKVNVRKYIEAQLDAYSTRAGWFFWTWKTEDAIEWDMSQLIANGIFPQPLSDRQYPNQCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7H6</accession>
    <name>G3B7H6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein 60S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_115741</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688450.1">
        <property type="nucleotide sequence ID" value="XM_006688387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7H6"/>
    <dbReference type="STRING" id="590646.G3B7H6"/>
    <dbReference type="GeneID" id="18247995"/>
    <dbReference type="KEGG" id="cten:18247995"/>
    <dbReference type="eggNOG" id="KOG1762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_1_0_1"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="107" mass="11076" checksum="BBE2ED89AA327D97" modified="2011-11-16" version="1">MSVDTSLSYAALILADSEIEITAENLLALTTKANVEVEGIWADIYAKALASQNLKDLFFNISSAPAAGAAAAGGAAATGAAAEEAVEEEKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7I4</accession>
    <name>G3B7I4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115083</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7I4"/>
    <dbReference type="STRING" id="590646.G3B7I4"/>
    <dbReference type="GeneID" id="18247713"/>
    <dbReference type="KEGG" id="cten:18247713"/>
    <dbReference type="eggNOG" id="KOG2957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="351" mass="40678" checksum="D871E27FC14367F2" modified="2011-11-16" version="1">MEGLFFNIDYGYVEGVVRGYRNGLLATNQYLNLTQCDNLEDLKLQLSSTDYGNFLAQHSGPLSTSIIRDNLSKKLYQQFQYLKQQSSGRMAKYLDFISYGYMIDNVALMITGTVHERDRSEILSKCHPLGWFDTLPTLSVATDIESLYNIVLVDTPLAPFFKGCLSANDLDDLNIEIIRNRLFKNYLEAFIKFVEADFGNPDKEIMLRLLNFESDKRVINIAMNSINNSDLTAEDKLSMFPSYGQLYPVYHHQLSNIDDIEHLKTVVTSVGEYKELFSEQQDSSGSARNLEDWFYYLEMQYCKNAFTQQFTLSSIWAWLRSKEQEIRNVTWIAECIAQNQKNRIDNYISVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7M2</accession>
    <name>G3B7M2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_124609</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689121.1">
        <property type="nucleotide sequence ID" value="XM_006689058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7M2"/>
    <dbReference type="STRING" id="590646.G3B7M2"/>
    <dbReference type="GeneID" id="18249039"/>
    <dbReference type="KEGG" id="cten:18249039"/>
    <dbReference type="eggNOG" id="KOG2805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000115">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="223"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="300"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV62951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="402" mass="45763" checksum="AA5C4C3AF821156F" modified="2011-11-16" version="1">MIRVAARYLSKVSLTQPVPKLTDTVVIAMSSGVDSSVAASLYKHYPNVKGIYMANWHKNAKCNEQEWKTVQEVCQQLQIPCERVGFEKEYWQKVFSPMIDNYSNGLTPNPDLDCNKHIKFGELVQYLDTKHPTDYWLVTGHYARVMNNTDGPQLLRAVYGQKDQSYYLSSINPKVLSKLLFPIGHMTKPQVRAIAADLNLVNKDKPDSMGLCFVSQDEKKFDKFLDEYIEPQPGNIITEDGKVWGQHNGLWYGTIGQRAKISMPQGDPRYQGTWFISEKRYDTNELVIVKGNQHPALFKNKVRVGRFQWLQEPVAYMAPRFSLQYRSLQSPVQVETLEIKGDEVEMKLVEFQRAMAPGQSVVVYDGDRVLGSGVLLEAVCEPQWMQKVPAGDYAMAANLIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7N5</accession>
    <name>G3B7N5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115118</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7N5"/>
    <dbReference type="STRING" id="590646.G3B7N5"/>
    <dbReference type="eggNOG" id="ENOG502QSSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008317_0_0_1"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="276" mass="29306" checksum="9C05B2E9F715B115" modified="2011-11-16" version="1">MFNNVALDPFNDPFTTAATPSLSNLTLNRNNANASTTTQPPGLTGGLGYSGVWNNSATKSRNNTIWNNTGSIWNSGGVNGTSSPNISNTNLNNLSSTNLNNLSATNLNNLSATNLNGTSGLPAPTTTNTDPHIIHSAAVQAFQMLSTSNSLEFGMAKGFTLFQATKNIVPQVSFNFNQFLGALTNTPSAYKFELIYDDFGTVNYIKVADATVNSPYQSSLNINLNGQGPSPTLTTPETTPFRVQNQLPNSQASQPNLSISLAASAAQYTPPRGFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7T0</accession>
    <name>G3B7T0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_95197</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688484.1">
        <property type="nucleotide sequence ID" value="XM_006688421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7T0"/>
    <dbReference type="STRING" id="590646.G3B7T0"/>
    <dbReference type="GeneID" id="18250487"/>
    <dbReference type="KEGG" id="cten:18250487"/>
    <dbReference type="eggNOG" id="ENOG502QU70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014928_0_0_1"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="247"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="770" mass="87911" checksum="4CE7A449EFC3C17D" modified="2011-11-16" version="1">MQKVRTRNTSTTQTAVRYKELEFKYLYFKIQKLVNRKVQISLKYEQLKQPEINLTLIKPIVTKIVALASNTSLGPKIRGNYGSTMSEFRAALENKVSVMVIHILMVLRYEFLIQSDANLIVYDLLMTKATVCELLAIRIYREYKAFDRVQLLFVDPLKKFTTLELVVLTKSKKFLSQPIIVKILEKFYNGELIMQELSDTKNEESTFLREQITNYNYSRASLTKINDRSRIVPKYQSLVINLKNLILTMLHVMIIVNQHKNLVPSDVLEFVFYCIGLHLNYEFFLKLLSIQHKFLRKILWFYMDFAIIMLIDINIILKVLSVFGYVSNSSYFQTFSILSILLIPRNLSMFNNYRFFSLIILGFRRMISNIAGLFCLFFSLIIAFYITFISINFNRSNSMIAFDLLQIFFGFTPAVWTNWDTYSPLGKVIQIGYLFLSQFIISTILAIVLSESFSEISHNIKEDFEYFKAVNLVIYFKSARLYSSRIGFIVKLPILVTILVYELLVTQISSSVPEEQKHFTFLAKDRDYYSDNDLVNMDNIHDESDVSILIRSRQTSVARAPGQPLVPNGVGAGRRYSQLDGGNMAFVVPPVSSGTVQPSGGSFSAGAPQTPVLMPIKSISTLGNFKSASTDSLFIGDLLAKRYGVASGATKPVSRVADGEWDTVLDRLGRLDDKLDQIQHQQQQATVKPPRKQLRLVSVATTDLEDINRSILDDVDNESVQLYDIREGSYDLSDHSLGSINSDDNVDAYRDDDTLSEVSEVSDEVSDDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8N2</accession>
    <name>G3B8N2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_108045</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8N2"/>
    <dbReference type="STRING" id="590646.G3B8N2"/>
    <dbReference type="GeneID" id="18246001"/>
    <dbReference type="KEGG" id="cten:18246001"/>
    <dbReference type="eggNOG" id="ENOG502RV3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030292_0_0_1"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14373">
        <property type="entry name" value="CUE_Cue3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041808">
        <property type="entry name" value="Cue3_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="319"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="371" mass="41558" checksum="20F2EA2D28B2FDB8" modified="2011-11-16" version="1" fragment="single">MSQEINLPIPTYPPFTLRSSLIDKDPVIWVHLLEGYVKLFQFLADGNFQYLTIKSKQQLYQFLKSYLFETFDEENKIFSLGAINVDIQKNEAELKKMVFNAIRLYSLLKFNLIGESIWYFIGIYVNKNHTVVRGLVDGSFKSKLNDNKKSGNISSIGSVHSHLEKLILNGKFTEKDLTTLSVLLGQSISTKTIVNLNSGKSDRVVNKKKSIEFAEKFVNSEWVDILEKAYANGRGLHAGVAKNAMIVSLISLPATQISKLVKSKDITKPSMMILSPLLCSIVISPEFGDLIVGTEEKLGFLIPDVLDMQPEDSFAGEEPFPEGLDNLISIFPDLTPDKAKAVLQQNENDVEHVINMLLENPGLIDDIKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Y1</accession>
    <name>G3B8Y1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115242</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Y1"/>
    <dbReference type="STRING" id="590646.G3B8Y1"/>
    <dbReference type="GeneID" id="18247789"/>
    <dbReference type="KEGG" id="cten:18247789"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_3_0_1"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05384">
        <property type="entry name" value="CAP_PRY1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442773" evidence="1">
        <location>
            <begin position="21"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="190"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="327" mass="33841" checksum="4EDA18DC443E9100" modified="2011-11-16" version="1">MKVTPLLLITALALWQQAQAAPAPAQTVWRTATQVLNQDGSIFTLLDELFGDDAATTAATTTAATTAAVQAAATTTAASSGSRWSGLLSKLLGYFDDDDTTTAAAAATTTAAVTSVATSAATTAATNDDLFTWFTTANKKTSAATSTSANTLAASSATPTTLSTATIKTGTTVASADASSTEEVSGSDKEFAESILASHNQYRADHNVAALTWNNAAYQYAQNNADNYDCSGVLTHTHGQYGENLAAGFKTGSAAVDAWYAEGSTYDYSSANTYDHFTQVVWKGSTSVGCAYKDCSAENWGLYVVCEYDPPGNVIGENSENVLAADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B965</accession>
    <name>G3B965_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein HSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_94704</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687994.1">
        <property type="nucleotide sequence ID" value="XM_006687931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B965"/>
    <dbReference type="STRING" id="590646.G3B965"/>
    <dbReference type="GeneID" id="18250428"/>
    <dbReference type="KEGG" id="cten:18250428"/>
    <dbReference type="eggNOG" id="ENOG502RQ0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435883_0_0_1"/>
    <dbReference type="OrthoDB" id="4095311at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57814" checksum="5958079B091F6401" modified="2011-11-16" version="1">MSTELSTTQQHAIDAVRARNDTLVSLSELGTQLRNPDFRNSPQVLELIPTLADIFVDDCHSEPLTLEALRVLINLTADSDRNRCQIITHAHLWRRVLGMVGTERVSILLAQFVRNTECISKFSQFFYKLGIHEPLVKSLFTGGEVDVASVEFLAGVLVPEVLTPEFVPVAERYLPVFVDLYRPHDDLDHEDTAELYESLSTLLYHLTQFDDMDTTVLPQLYPLFEQYTESSSVSRQLFSTVGNLSSMHRFGTIADVHTALQWLPRGNLYRQAAAYLVVGNYVQSQAQCDEVNALVGDTFIRDYFSTAFSDVVQYQSLHAIKNLVTSATSKQVLDHPSFMGFSKVLIDNQSYYQEIFLTYLACVKKLVRLTFNDVSTSIYEYERLWSLVDSDEIYLCICPFMDRSECDLNQRLLTKVFCAEMPVEATRVLDRLKAQAVVLKNNVEMVTRRLGADSNFKNEVLVRLQKLGEMVSGSDESHPQHQVVANNARYVAGAMMAVGDAEVVAAARQMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B979</accession>
    <name>G3B979_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF605-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_115280</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B979"/>
    <dbReference type="STRING" id="590646.G3B979"/>
    <dbReference type="eggNOG" id="KOG0917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679712_0_0_1"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="379" mass="43194" checksum="4F0306FB12D0AD00" modified="2011-11-16" version="1">MISDIPESLKTNKDIVPYIVRSNELEDINPIVSYYCKIYVLEHILNKKLHKDDKEVEAFTIHLLDDTELMKTSDDDSLTKVLNDKNLSINVVFSFSLKIFNGCIHELNNYTGAKLALVNKIKACLNFMSLTEVFKNDDIDFSSLTGGKYTSYDEFNKFNKDRIKLLKYNLSKLIKDEIEIKGEQDELDQELQRMESEFKEAEDEEPKEAEDETSKEDLPQETLPSLGSPEIKASSEDPPQFIDSEPEEPVTLPGVPHFSPDDDNDIKLPGAPQFLPHDDLSHINKTSAIHVFEPEKDDPQKKEPPKPQSKPQKKPVHGHAPITKEHINSILDRQESMTKAQKHCKFAVSALNYEDLDTAEKEVLQALEMIRLVKQAGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9S0</accession>
    <name>G3B9S0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115412</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688891.1">
        <property type="nucleotide sequence ID" value="XM_006688828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9S0"/>
    <dbReference type="STRING" id="590646.G3B9S0"/>
    <dbReference type="GeneID" id="18247856"/>
    <dbReference type="KEGG" id="cten:18247856"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF3">
        <property type="entry name" value="AMMONIUM TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="33"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="499" mass="53968" checksum="36BE668FA6C309B1" modified="2011-11-16" version="1">MIGNSGLASAKLLWAKRAEEDPNAAFDKAEIVYCLFCAMAVFLITPGIGLFYSGALKRKNVVQVLFQTYMVTSVVTIVWYLLGYSLAASPTSTSVIIGDLAHAALRQNDAYGLYEGATIPSIVNFCFNTYFPVATVQIFLGSIGERGRVLPSLIIGIVFTIIVYCPQAYWVWGANGWLYTMGELDFAGGGPVHVSSGVASLVYSWYLGPREQPGKRTGRIPSFRGYSSMSSVIGVTLIWAAWLCFNSGTLLAVNIRTGYIFANTMIASAFGCVTYVAVDSMITGKYSMDAACEGVIVGLVNITPSCGYYWPWAAAVTSIIDAVACRLLIGFNKWTGIDDYSKSWVVHGVGGIIGGTLVGIFGSSGVAALDGVTVIEGGWVDGNFRQLGIQIAAWVSITAWTGIFTLITCFLVDHIPGLKLRATAEAEEMGMDLYEMAETLDEFGNDYETFFIQYASKLRQMADHLEKHGGVVEVLDGSSTRFSARNSHSSIQMEVDQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9W6</accession>
    <name>G3B9W6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_94251</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687512.1">
        <property type="nucleotide sequence ID" value="XM_006687449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9W6"/>
    <dbReference type="STRING" id="590646.G3B9W6"/>
    <dbReference type="GeneID" id="18250376"/>
    <dbReference type="KEGG" id="cten:18250376"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_5_1_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04207">
        <property type="entry name" value="CuRO_3_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442778" description="Multicopper oxidase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="73"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="214"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="511"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="75801" checksum="864F0BA0272FC3C8" modified="2011-11-16" version="1">MVKISTFALVALSLCGFALSEKVESNAAPALEIRGVQDSSDLSEPLEKRSKRLKSNLDLIPSGATVNYQVWNLTETEVMPDGHYRRGFLINGESPGPLIDGNQGDWVVIKVNNFLTVPITIHFHGIHQNGTIFSDGVPGVTQWPILSGDTYTYVWKMDQYGFYWYHAHYRAYANDGIIGPIYINPSDEVGRPYGEITNDTDELSLLNRLEKKPNYLILSDWFKETYDEIAVKMFAYGMDPSCVQSLLINGKGRHYCFPNSTFASQGATKYEKYMGATGADTWHMDSFGCMDLGTLNGFTSIEYNTTLLEFPGTNTECFNSTVDQEVYYTNDEDYVFFNLINMGGEFSKTLSVDDHNLTVVAIDGSYIHPKVVQQLYLPIGLRVTVAIKTVEDEHENTDEPFAIRVQGDDMPQLYTGLAYLQYGSYSNETYQYVQESVAIEDTNGVLHNNLAGDLLDSSFIKFDPFSSSPLDSTLKPPTGAADVTIQAELTRPGSTTFTIFNGVAFDGGMEMNYPILFKLQGNDSINATQAFGGSVVDAGIKEGDVVDIIFQNTPLADHPMHLHGHTFWVIAKNDTVSTFAYNTTEEALEDGSDDLFNFEDPAYVDNVAVITGGYAIIRFIASNNIAMVHCHIQTHLAMGMGGVIVEDKEHLDKVPENLLKQNHADYNSQDEWIPSELNITIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAC2</accession>
    <name>G3BAC2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_108385</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687574.1">
        <property type="nucleotide sequence ID" value="XM_006687511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAC2"/>
    <dbReference type="STRING" id="590646.G3BAC2"/>
    <dbReference type="GeneID" id="18246025"/>
    <dbReference type="KEGG" id="cten:18246025"/>
    <dbReference type="eggNOG" id="ENOG502QWA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042082_0_0_1"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54491" checksum="E974F93B9D6986A3" modified="2011-11-16" version="1">MSDTSVLIAVAVAVVIHYLFKKYVDATKDVPDLYLSEQSLVEATRLSDQSAIYKSNKLDFGNGLRVGLDIRYNHYKIRHGNPCDVWELLVAGLKSNPQKLMVLNNEVIKISELNFKVNRVTAYLDANGIRNIAVKYSDFMASIDHTVILFACLINAVTVTFYQTSDDLQTLEVDHFGDQLLQEVDSILSATGELFTYENIYNFDKDKGARIRVVKKLDGSTIRTTEYLAVNLVSNIASTLKHLPPNETIGPKDTILVTNVNPHTSLVNTLCKVLTGFVTNSSVIITNSSSWENLVSYNPSVMFSDSSVYSKGELVHKLQRGLSVVGRTKYKLSMYFLSQGKFSRFGSSNLRLVYFTTIVGGPESCYFATAKLNQLRALLNARVIVEYGYDNLIGPVVLSDLYDYRVLDGAITENLVGSGCIFQAVEIKLVNLKSDNFGDIMVRGYNIGKVNNYIIGGGSGERVNKDNEGFMLLEGVKGKWGSDGCLYIYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAE3</accession>
    <name>G3BAE3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_94922</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAE3"/>
    <dbReference type="STRING" id="590646.G3BAE3"/>
    <dbReference type="GeneID" id="18250454"/>
    <dbReference type="KEGG" id="cten:18250454"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_17_3_1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="112"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="458"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="685" mass="79914" checksum="855A4F00A0C16183" modified="2011-11-16" version="1">MTLEDPELQHKASEILNESDNEQDEFNSLPNNAKVERLNNLIKKSQIYSQIIADKILQKQIQQKDNGSPTKKRQKRNGNVLEMLTSKQSSRQPKLVKGTMKPYQLEGLNWLIRLYENGLNGILADEMGLGKTLQCISFISFLIEQGITGPYLIVAPLSTISNWYSELKRFTPSLQVLQYIGTKDSRKIMGFEGFNIVLTSYELSIKDFSKLAKCNWKFLIIDEGHRLKNMDCLLIKILKKLDVANRLLITGTPLQNNLNELWSLLNFILPDIFHDLKLFQQWFNFDEIENIQSVKDEEIKQFIEKNFKKNLIKNLHTILSPFILRRLKKDVLNLPPKKEYLIHIELTDYQKRLYLSALNNDLYNGIFELYKYEYEKFNLSRRDPKKYGKELDDAIKSQLKSLKLQNLVMQLRNICNSPYIYYEPFPVEKNLTKYDSSPRDKEDRFIELLIKNSSKFTIIDQLIDKLEGHKILIFSQFTRTLDLLSDYFRYKGIETCRFDGSTAHVDRDKEIKKFKTTASQVFLLSTRSGGLGINLIDADTVILFDNDWNPQVDIQAIDRSHRIGQDKPVKIFRFLVKNSIEELLIIKNYSKRFLERLVIQIGSKNFDRLADFEVEFSNLVKLSQQFGMSIEGFEFDINNGSGCPLLTEEELDELTDRSDECFKNTGRWDNISVFESVSKLDEQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAL9</accession>
    <name>G3BAL9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Receptor L-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_124121</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAL9"/>
    <dbReference type="STRING" id="590646.G3BAL9"/>
    <dbReference type="eggNOG" id="ENOG502QT4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1087993_0_0_1"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442890" description="Receptor L-domain domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32268" checksum="5628C1ADAAEDD8A3" modified="2011-11-16" version="1" fragment="single">MLLINIFFLGLAIAVNATQYFECQIEDPIQSIESFYAISHCESIKGNLVIEDLDVPIIEFKRLREINGDLIIRNSPELVRVESPILGKISGSLKMNELTSLSLISFPSLKSVTGLDWRVIPLLSNVRFSSEISDVQDIIISDTSLTGFSGFRAEQLQTLDINNNRFLEVLNSNVENINGMLHIASNAKSLKLNIPKLRSVNNVSINDVEELDLSALTEVKESMSIYNNNFEELKLPNLERVGGTLSITKNSQLSTIELDNLEEINGGLMIINNTQIQKIEFLANLTKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB28</accession>
    <name>G3BB28_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenine nucleotide alpha hydrolases-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115591</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688959.1">
        <property type="nucleotide sequence ID" value="XM_006688896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB28"/>
    <dbReference type="STRING" id="590646.G3BB28"/>
    <dbReference type="GeneID" id="18247928"/>
    <dbReference type="KEGG" id="cten:18247928"/>
    <dbReference type="eggNOG" id="ENOG502QRPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597158_0_0_1"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="291"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="462" mass="52111" checksum="A124C0D68E1C7B66" modified="2011-11-16" version="1">MAGRQSRLEAERLAIIQKSMSRGRSPSPNQSNPNSRSASPSNDAKGELKWSIINHDPSERLVKLTSNDGDNDVVPLDFDDEQSEEEHLSDDDDQEKFQYDDTGNILPNFACRDEKIHEISHILENSNLSDTSTIKKLEELTASERAFANAKKAGKPIDEEALEKLKNEKNQLLGGAVDLDKSDQDFASRRQKLEDYSSYRRKIIDHENEKFKQSNSPIAEPVAVDDDKDFMIPYTSAIEDKLDSEFASKLNETIIEGKVDSSRPQSRVIQTITRGNFFQLIDPKVKPKMFLLCMDFSPESIFALEWSLGTVLVDGSVLFIVYVIEENDANHHLKGNTNSESARESHRLDMLNKAKQQVLNLLKLTKLQIHIVIEITHHPIPRHLILEFIDHLQPTLVIVGSRGQSAIKGVLLGSLSNYLVTKSTVPVMVVREKLKKINRFKNGSSVFSNNIKPLTLSEARID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB34</accession>
    <name>G3BB34_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_136068</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB34"/>
    <dbReference type="STRING" id="590646.G3BB34"/>
    <dbReference type="GeneID" id="18249934"/>
    <dbReference type="KEGG" id="cten:18249934"/>
    <dbReference type="eggNOG" id="ENOG502R17J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008516_0_0_1"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="215"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="656"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="723" mass="81364" checksum="B2E659F989E1C912" modified="2011-11-16" version="1">MSHNPYTSSAPLLSTADNSAHLLSPHAIARKVSSLSNSSSTYSNQTQHSFTSNQSSASQGSVVVSKSADVSKATIQSSVLDYIKNSDSDFNPNELFQQRQQRNFITNFDKTPSQKLPSRAVPGPEPRETSPLSFDQNHNDQHNSDLDLGRQPLAIGSGDESEIPTRKNSSIFFNDSFEEEPEDENFDDDDYDYDYDDAEDDDDMPSPPRSPPREIDPGKLYGLYDFSGPDPSHCSIARNEPVYLINDQDNYWWLIKKLTKQERVQLTTERNLNKSEQELNEAGDEYLLSDEEDGKIGFVPAECLETYGERLARLNCFKNEELEKSSRDLLVSSNPSSSDNVLGSPVIFQKTPDTTISRSGSILRDGTKQLINKSVTFEDLGVLELNENSDSGGEDEEFPSHYNIPEIEEIHREIHADDDKKSEILSETFPSESPLVISKRKSTSGSPSPPKDMSLSEITPDTPQSDYQTPIPAPLNIFAKDNVSPEYRTPGECKSSEENEDATPVENYKTPQEHDYDYGNFTDEYLDDKDTWTQTPTSERLRRSEILTRLNQVTSDIQNELDGYDEDLDYRDTHQVFGTAEDKYLSDDYDSRNSYLLSFQDQRDSVAENDEDEDLGEYKGFDDKEKYLDDKEKVLDDKALGEEVGSGYGDILADLDHGSDLDNLPQDQSSPLRPQTSLPKPTTPDSKILAARRKSTPVHDMFVPILGKFDELAEKLAEIDDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB48</accession>
    <name>G3BB48_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_95030</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688308.1">
        <property type="nucleotide sequence ID" value="XM_006688245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB48"/>
    <dbReference type="GeneID" id="18250468"/>
    <dbReference type="KEGG" id="cten:18250468"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="29"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="566" mass="63042" checksum="DDA1744AA58703B5" modified="2011-11-16" version="1">MWLLSKFAHKDDSAHPAPIETYNSRLLLLALAASTGSAMYGYDTGFIGGAISLPSFTARYGLDSVTGTQLAALKANIVSTFQAGCFFGAIIAYSVNEKFGRRKTMLAFAIVFVIGVTFQIASSGKIGLIYAGRAITGLSVGTMSMIVPVYNAEWSPPAVRGLTVGLYECVYQTSSLLAFWVNYAVKIHQPDTSERQWQIPFALQYIFGGAVILCMWFQPESYRWLIKAGRVDDARDALVRIRKLPAEHPYINYEIQSVLIQLNEEAQIAKKDVLRETGNFIQRNEIYIKLKEVTKSGMRYRLFVGVSVMVWQNLSGINALNYYSPTIFKSIGVSGNNVDLLATGIFGVAKTVTNIIAVLFMVDYFGRRGPLLFGSSLTFVFMMYLGIYSQLSGSFDHVVEKDGGSRAALACVYMFAVFYAFSWNCMPFIVCSEIFPMAIRNFCMTICVMAQWLMQFVIVYSNPYMMTNIKYGSFYFFGACLLLSVPFVYFIIPETRGISLENMDVLFSIRGTALKKRKKADEIIAMRKQEVIMDESGKVAVAEVEDVDGGSIEKVPTSSTRSIQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB60</accession>
    <name>G3BB60_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_125733</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB60"/>
    <dbReference type="STRING" id="590646.G3BB60"/>
    <dbReference type="GeneID" id="18249124"/>
    <dbReference type="KEGG" id="cten:18249124"/>
    <dbReference type="eggNOG" id="KOG1104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011380_0_0_1"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="7">
        <location>
            <begin position="38"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="904" mass="103287" checksum="740BF599E17D64EE" modified="2011-11-16" version="1">MEQDRKRQREDDDGYGDEHVRPEFDSKRARDDPTNELISNVCKDIRRIGETANLHNQVDDMSYISNPIVVEFEKIDRLRSAVLSILHAIVVEQPQKISSLAALVIICNAKNFLVPKYVIEFFHTKLQEYVAIKSGTDNFNHIKNILKFLCSLSPIIEEGALFNLLSQFINLSIELGSDAPLGRAIHYNTLMAVPYLLSWDESQAEDVEKLVSAAGGFAHGDASDFSLYSHFNNKNNGVEVPYRPRAIVELVYPALLEAQKTGFASIRDLFINYKELVDPVVNDALQANKISNELVKHKLPQVSVNTETLSSYNPSSESLSIDSLWFKGPRLTFELYSHTTKDFPTLPEISSYAGLFFRDICTDLITNLSFNKGEASIQLSILDLYFNRSLFCPPGSSVDTLVAINNDNISRENVPPLSTWKVEDVAVESLLSLIFLTPTPPNLEIYYHSVLISCCKESPEAIAPVFGRAIRFLYSHVESLDFETRIKFMDWMTIQISNFDFSWKWDEWVSDSQALSASRFHPKKNFIRNLITKELKLSNKKKIKESFVTMDPETGDVVELDEFFKYLDLCLFDNDTKHIINYDTDIYGGDDAAKEIIAKSIYEKKETFTVTTSPQTEMFFVFGNDQLPYHHVCDKFHKFLLSNSKSKREFAEMIEELKSDITSDTINKSKFIINLVLQTYCSIGSRSIYSTISILTRDLVKLKWLTGNTLSEEDYVGNSEDYKFPELSLQNEHEQTAELQNYVVDAVFRIWIYRPQFIFLILEYLVDVKLLDFEVFVGRCFDLEHNLVVDRIDCFEALARLLAASSKAHDLARITVVTSKIIENLGQVLDKLEVSDDAIVPIDNYTAETAAKNDLQWLYYDYLDLFKWVARKYGTSTETETLVDLVKNSSLKADLTSLSAQRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBI1</accession>
    <name>G3BBI1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115013</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBI1"/>
    <dbReference type="GeneID" id="18247673"/>
    <dbReference type="KEGG" id="cten:18247673"/>
    <dbReference type="eggNOG" id="ENOG502S0PT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1717562_0_0_1"/>
    <dbReference type="OrthoDB" id="4091299at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="153" mass="16837" checksum="70FFB3BDE08F4489" modified="2011-11-16" version="1" fragment="single">MSGLQSNPLLSDPSIVQVSSNDQTSINIAAQNQTTSLEPSNVLSQLLDSAMSKAAKETSPEFELKTSSSSSSPKSVKSNRYEISATKSNSSQVYSIDELMSLIPLADATIADQLPPKEFWCLFHVNKKQHFQKEFGGKHNKRNNTFNNNNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBS7</accession>
    <name>G3BBS7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_136162</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688397.1">
        <property type="nucleotide sequence ID" value="XM_006688334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBS7"/>
    <dbReference type="STRING" id="590646.G3BBS7"/>
    <dbReference type="GeneID" id="18249946"/>
    <dbReference type="KEGG" id="cten:18249946"/>
    <dbReference type="eggNOG" id="ENOG502QWCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034381_0_0_1"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05840">
        <property type="entry name" value="PWWP_ScIOC4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035503">
        <property type="entry name" value="IOC4-like_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="3">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS N-terminal" evidence="4">
        <location>
            <begin position="311"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="51003" checksum="C7F7FDE8F03B5DC2" modified="2011-11-16" version="1">MPPKNSRKLAFKPKDLVLAKMHGFPAWPSFVMPTGMIPESIFEVKKKTTEFCVIFIPDGDFYWFPEKNLEYLTPDKLDTRISKIPKNYKKPKSKGKSSTINDAFLATKGLEFETFMRQLKQRDSGEVPYDAPDSEDHPVMSKNEEDEEDLYLSKDFKEPEDEDEDEYELYTNEVKVKHQEEVDEEEEDEQPQPPQKTNGRRSARSRTRMGNGNNNHNGNGHDNGNGHDDGYGESVNSSTDDSTGELSTNGIEKQSDDEVIARKRTANGSSNNNSNNKMKRFKTESPGPVGSHHKVLTEEEKLQQLWLCRIKLQKALIQRDKDEAPPNADELSTSRLILRRLVDFEITLQLLKTTKIHKVLKCIIKDKDLEYPESFKLHDKCQELLNKWAKLIEEIKLEKTANFLSRQRTSNGSEDRKIDDSEISDIKDRSVKSPNELKFASVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC73</accession>
    <name>G3BC73_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116158</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690236.1">
        <property type="nucleotide sequence ID" value="XM_006690173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC73"/>
    <dbReference type="GeneID" id="18248192"/>
    <dbReference type="KEGG" id="cten:18248192"/>
    <dbReference type="HOGENOM" id="CLU_1740277_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="150" mass="17168" checksum="24AE6C43A01F94B8" modified="2011-11-16" version="1">MKASKESKIHNKRFEDLLQCHSSGNGIGENREKGSHKEICTILEELSEFKAKLVNTHFEILHENILCLVEDYTETGVNRQMTINSKFMDWATTVSWVLRTFVKNNNGSYCTSIKAPKYYPGILPDVTGTELYNILDKKHAPPPYTKKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCF9</accession>
    <name>G3BCF9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_112042</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCF9"/>
    <dbReference type="STRING" id="590646.G3BCF9"/>
    <dbReference type="GeneID" id="18246340"/>
    <dbReference type="KEGG" id="cten:18246340"/>
    <dbReference type="eggNOG" id="KOG0437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004174_1_1_1"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="199"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="808"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="12">
        <location>
            <begin position="956"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1093" mass="124063" checksum="8BF77E3E092A9B77" modified="2011-11-16" version="1">MSAPIKLENTSRRDTLREIEKKYQAVWAKEKTFEVEAPPIEEVPIEDTDEVRRIHPKFFALMAYPYMNGVLHAGHSFTLSKLEFAAGFERMRGKRVLMPMGFHCTGMPIKAAADKIKREIEDFGEDFSGCPPEDVEEEEVKPEKAKSEDVTKFKAKKSKAVAKQGRGKYQFEIMLQLGISREEVAKFADPHYWLEYFPILTQRDVTNFGGRVDWRRSMVTTDANLYYDAFVRWHVQRLRDMNKIKFGERYTIYSEKDGQACLDHDRQSGEGVNPQEYTGIKIEVTEFAEAAQKVFADNSFDTNGKTVYLVAATLRPETMYGQTCCFVSPKIDYGIFDAGNNQYFICTERAFKNMCYQKITPKRGYYKSVVEISGSALIGSKIDAPLAENKNLRVLPMDTVLAAKGTGVVTCVPSDSPDDYITTKDLLNKSEFYNIDKEWVCDNIVPVIKTEKYGDKCAEYLVKELKIQSPKDSVQLAKAKEMAYKEGYYNGTMVIGKYIGEKVEVAKNKVKQDLIDQKLAFVYNEPEGVVISRSGDDCIVSLEDQWYIDYGEDSWKADATTSLNNMNTYSKECLHAFEGVLDWLKNWAITRNFGLGTRLPWDERYLVESLSDSTIYMAYYTIGRFLHTDYYGKQPGQFGIKPEQMTYGVFDYIFNGAKTVDTDIPIEHLNVIRREFQYFYPVDCSISGKDLVANHLTFSLYTHVAIFPKKFWLQGVRINGHLMLNNAKMSKSTGNFMTLSQIIDKFGADASRIALADAGDTIEDANFDESNANAAILRLTTLKEWCEDVLKNQDNLRGGEPNNLFDDAFENEMNDLIERTYESYSQTNYKAALKTGLFDFQAARDYYRDSVSGTVGMNKKLVLQYIENQILLLAPVASHFSEYIYREVLNRSGSIHTARFPRASKPVSKPISDALAYVRELTRAVREAEVNVLKKKKGGKPSEVDGSKPARLTLFVASSFPEWQDSYIDLVRELFEAHTLNDNSVIKQKVGKDIKRAMPFISILKQRLAVEDPKTVFNRELTFDEIDTIKAVMANIQRAPVSIDIQEVEVITIASGSKVGKNIATGEDYEITITGKIIDSAVPGQPGVMIKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCI5</accession>
    <name>G3BCI5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_116233</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCI5"/>
    <dbReference type="STRING" id="590646.G3BCI5"/>
    <dbReference type="GeneID" id="18248209"/>
    <dbReference type="KEGG" id="cten:18248209"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_9_2_1"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04901">
        <property type="entry name" value="ACT_3PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="394"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV60171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="464" mass="50340" checksum="80563971B96B051C" modified="2011-11-16" version="1">MASQQNIIDSFQKAVNLTGSPNAVSTSPTQSYLSNYTPYKKQAKALKPFSTGDMKILLLENVNQTAIDIFKGQGYQVEFYKSSLPEDELVEKIRDVHAVGIRSKTKLTERVLSAAKNLVVIGCFCIGTNQVDLEFAAKSGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIEMHTGTWNKVSAKCWEIRGKTLGIIGYGHIGSQLSVLAEAMGMNVIYYDVVMIMSLGNSKQVGSLDELLNKADFITCHVPATAETNSLLSAPQFAAMKDGAYVINASRGQVVDIPALVQAMKVGKIAGAALDVYPHEPAKNGEGLFSDSLNDWASQLTSLRNVILTPHIGGSTEEAQSAIGVEVSSALTKYINEGNSSGAVNLPEVSLRGLDLDQQNSVRVLYIHQNVPGVLKTVNNILSIYNIEKQFSDSRGDVAYLMADLADVDSSDIKSLYEQLEQTPYKIVTRLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCR4</accession>
    <name>G3BCR4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_137334</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCR4"/>
    <dbReference type="STRING" id="590646.G3BCR4"/>
    <dbReference type="GeneID" id="18250056"/>
    <dbReference type="KEGG" id="cten:18250056"/>
    <dbReference type="eggNOG" id="KOG1989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011638_1_0_1"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE AKL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="854"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="887" mass="100324" checksum="EA4ADE84CE20E378" modified="2011-11-16" version="1">MEPLKKLPEGTKMTVGSHKITILSYLSEGGFAHIYKVQMSPKEDDSDIACLKRVIVPDKSGLDQLRKEVDVMKKLRLSRCVVRYFDSHAERLESGAYQVLVLMELCPHGSLLDYMNAKIKTKLTESEILSIMFDISIGVYEMHRSKMIHRDIKIENVLINAHHRFKLGDFGSTSSPLMPPTNQQEFQALAHDITYQTTPQYRSPEMIDLYRNLPIDEKSDIWALGCFLYKLCYYTTPFEANGDIAILHASFQFPPAPVYSGDLKNLIIIMLQENPFFRPNIVQVIKLVCKMTNADFKTLKIQDIYKVGSYDFQALHDYQQKKQKDLLQQQQDYFEQQKKLQQQQIQPQPQPQAESLAPSAYEKDFIDPEVSESDDSSTEGLDTTLGDLADLEDVEQRYPSLENIIVENDAPKSGTGSIKSAGPKDSKIEKSAVPPLPMVPNYPVQPPILSSHDLQRLTPEQLQQYNYSHQAYQYQLSHWMSYQQAGVSQQYLRPEPNKEKYSTEFEKKEAWEKRQPSMGEEAEKLVDDIFGSKSRSPTDVLQIQQKTSQSIKSEPAGGYLESEDEEDVNVIIKPAKVRLSKSNNSSELSLSKAKPEPSIEVVSDTKTDQLLPTDLKLLRKDNFEKKEVAETRYEAREDLPVSNSTTGAFPKGEPMIKDNRVSASSNYLSQPLVSNPVQYPSSTMIRSGSGKNLNPFPVNPRSVSEANFSTDGASDSKKFTNPWGDYRSTQHLPKASQLSQQVNSLSISDNRGDSSTPKKPSTEEPNLINLEIGLDSESSLSTPIMTSTFLNPLSDSLIDLDLDDKFQKPSDRPHFKKKVPSISNPSDFRVQEEVIDWASDDEDPEQMNRLAIRSSLKKSARRSGEHKRSESTSGESKKRLSRLIQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCY2</accession>
    <name>G3BCY2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136724</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCY2"/>
    <dbReference type="eggNOG" id="ENOG502S1A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973177_0_0_1"/>
    <dbReference type="OrthoDB" id="4096434at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="286" mass="33076" checksum="8BE8399BA68327E5" modified="2011-11-16" version="1">MSYIDPKLIYSSTHLSKIHPIHSFDPIETLVPLECSGLQVSRSVSITSNRSIQIDASPRSEHLSLSSSPMNDPYDPSHAPLLESQETNTKISFFDSFPSLFDSSQSESESHECPESCKLVVSFSYDRLKLIAIVRSSITKFEDLVSDTKYKRKPTRLEYKNKLAVHGGAEEKPEVTYLSRISLFQLSRILNLSEYDINLTKTVQHQILDVFTKHCDFRLGYDTWVKHTDESQRDRALSILYEFFRDVYPFTKKQLQVVIRRGSYRCMQSRLRRDKHSALKKILRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCY4</accession>
    <name>G3BCY4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_127270</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCY4"/>
    <dbReference type="HOGENOM" id="CLU_2489308_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="87" mass="10050" checksum="F90E445EE12767DC" modified="2011-11-16" version="1" fragment="single">QQICIRFGRRRTHQLVFSFFFPYASNPIYKFTGDIKNLEVNLKELISDSSSNKCPILLGSHFSGPTYCLYEHCLYYTINPSTCSQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD16</accession>
    <name>G3BD16_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 2-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_132536</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690108.1">
        <property type="nucleotide sequence ID" value="XM_006690045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD16"/>
    <dbReference type="STRING" id="590646.G3BD16"/>
    <dbReference type="GeneID" id="18249629"/>
    <dbReference type="KEGG" id="cten:18249629"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_0_2_1"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="96"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="557" mass="63619" checksum="90BABE6F3F996A12" modified="2011-11-16" version="1">MTSPTSPVFAEDCELTNGFGSEPISVSTTPIPAANSGRRTTKRWSFHNDSKPNLVERPSEASNQGRRRLSDITGVDGVHKEIDANHISPAQLYSTESGRLFHAGKICIVLAGLPGRGKTHLSVSLTRYLRWLGVKTHSFHLGDYRRRNFDDLDQSLFIEDTKLRLKIINECTNDMLNFFENDKGQVAIYDAVNPFPKNRFELHEKFKNLNIQTLFIESSVTDDTIIMKNMESAAASSPDYANWDYDKAYKDYSDRIKALMPYYIPMGDEDDNNKLSYIKFINFGERIELHNSNYGYLINKVVFFLMNSRIKSGSVFFARCHNNSINYSDDPPLDTNGKTYAKNLCYTLIEHLQKQRKEYVENIDLGIQDEDGTPGTNTPTSLKQKRSFSLDEKHLPAGADGVDVNSMVVWTSVKKRTIESTKYFKAANINVRHRIQLSQKNPGVVGSMEEDEIKEAFPTEYEQYLKDPYHHRFSRAESYHDLAIKIEPLILEMERMSGDVLIIADESVLRVFYGYLMASSCFDIPYLPFSQDEIIEIKFNAYANVASQIPIKDFSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDA4</accession>
    <name>G3BDA4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_110382</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDA4"/>
    <dbReference type="STRING" id="590646.G3BDA4"/>
    <dbReference type="eggNOG" id="ENOG502SC4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083361_2_0_1"/>
    <dbReference type="OrthoDB" id="5554151at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="122" mass="13402" checksum="FFB41F66BD70002D" modified="2011-11-16" version="1">MSSGSLGHRVKQNLEYHNLWSDVQTFVIGSGPSIVDILYAAPPNNPSTTNPTDLELDGGKQWIIPQAVDSQKNLSVKQINTWFVEIGKISGQRPKSILIALVNDDSTVVYYKIHDGVATPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDI7</accession>
    <name>G3BDI7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116359</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDI7"/>
    <dbReference type="GeneID" id="18248264"/>
    <dbReference type="KEGG" id="cten:18248264"/>
    <dbReference type="eggNOG" id="ENOG502RQDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2164308_0_0_1"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="111" mass="12394" checksum="1CA85C225C2D02B1" modified="2011-11-16" version="1" fragment="single">MTEANPLSLANEAHLNEKVVAAKSIETNHANNSNSKTEFGPLNTDFQADSQKDSSKNHQSSKDEMIQEILQLKASISHLVGNVRDIKMLCEKSENDNQYLQEYVGTLMKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE54</accession>
    <name>G3BE54_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116511</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689674.1">
        <property type="nucleotide sequence ID" value="XM_006689611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE54"/>
    <dbReference type="STRING" id="590646.G3BE54"/>
    <dbReference type="MEROPS" id="M24.A09"/>
    <dbReference type="GeneID" id="18248339"/>
    <dbReference type="KEGG" id="cten:18248339"/>
    <dbReference type="eggNOG" id="KOG2737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_1"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="475" mass="54099" checksum="B58ACD3B8D734035" modified="2011-11-16" version="1">MVEQEIEALKGKKYPAKQHCRNVCSHFTTKKPNAKSAGHYFFVSGEREVLYQYSDQAKPFRQNRYFFYLSGCDIPGAHVIYNCGSDSLTLYLPEIDYDDVMWSGMPLSIDEAYAKFDVDTVKYASELEKDVAALSSNQIFTTDINDSNKAFSHALTAGDPDLFYALDESRLIKDEYEIELMKHASKMTDNCHFAVMSALPIENNEGHIHAEFMYHALRQGSKYQSYDPICCSGPNCSTLHYVKNDDEMAQKRSVLIDAGCEWSLYASDVTRCFPINGEWTKEHLEIYNIVLKMQKATMDMIKPGASWDECHLTAHKVMISEFLKLGIFKSEYTAEDIYDSKVSVRFFPHGLGHLLGMDTHDVGGYANYQDENVLLQYLRLRRPLQKGMVITDEPGVYFSPFLLKDVLETPEKMKFIDKEVLDKYWYIGGVRIEDDLLITDDGFENFTKITSDPAEISKIVKAGLAKGSSGFHNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE84</accession>
    <name>G3BE84_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_127755</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGV60484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF14">
        <property type="entry name" value="AMINOTRIAZOLE RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
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    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
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            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
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    </feature>
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        <location>
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            <end position="220"/>
        </location>
    </feature>
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        <location>
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            <end position="252"/>
        </location>
    </feature>
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        <location>
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            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
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        <location>
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            <end position="359"/>
        </location>
    </feature>
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        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="524" mass="57579" checksum="DCC6C09A784322BD" modified="2011-11-16" version="1">MVILYKRKLSSPRNVTSIIKSSMSETEFKFKSIHHEISLVTIIAMAQILCQGSITMSMSIMDVVLKSFPGEYQSSIKVWFMGSFALTLGTFILISGKLGDIYGLKCIFAIGWVWTCLSALLTGLSVYTHSVVFYIICRALQGIGFALLLPCGMGIIGNLYPVGFRKNFVFSIVGAAGPFGAALGALMAAVIAQLSWWPLCFFIISIIGAAFAGLTIWLIPNSINAASKDFKEFDLIGSLIGTTGLILLNIVLNQGPLAGWNKPYIIALLVISVFLIGGFFIYELKFAEYPLLPMSIFNYKIGMVLICIALGWGSFGIWQYYYWIIMLELRNYTPIAVGASYIPVLVLGIVAAMSVAFIIHRTRPSYILFAASLGFHVGCIMLAVTPVKQSYWGLTFGQLFILTWGMDLSFAAGSIILSDFLPKEHQGMAGSLVSTVVNYSVSLFLSLASNIEVETYKKVHSSIKSYRNAIYFGIGISGLGVLLAFAFILFQIFLHDKNDTLDKESNFDLQSETTQVPSDDELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEE6</accession>
    <name>G3BEE6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_127853</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEE6"/>
    <dbReference type="STRING" id="590646.G3BEE6"/>
    <dbReference type="eggNOG" id="KOG1092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018687_4_1_1"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family, member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
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        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="230"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="535" mass="61557" checksum="63608BDBC9F56A7F" modified="2011-11-16" version="1">MGKKKQEMSQVYNSNNEFIFGEKGGKGKNLSTFLKNLSLTTSPSQPQSEFNEANSNIYGSLSYSNPNTNEISRSNPSLARRASPKRSLSGPTNMSFAHSLTPTASEALRTNSPTRTKRVVSAKYADLDDDWDANFDDARVDTDMPSVRREGFGNTFLDPSPMLDSLYPDLTIPAGTKEPVKDSIDLEDMKIKLEINKLNQLNTKFLKFKALLTQSSNINLQELRKLSWNGIPSNLRAISWQILLGYLPTNKSRQSATLKIKRQEYLDGINSSSLNLNRDKQIYHQIKIDVKRTNPTVKLYGHPEVQKSLRKILYFWAIRHPASGYVQGINDLVTPFFQIFLTNYIWQLQPLLNDPQLFNYNLHNLDPTQISSRVLSIIEADTYWCLSRLLETITDNYIHQQPGILKQVSDLKNLISKIDIDLIHHFEQENIEFLQFAFRWMNCLLMRELSIDLIIRMWDTYLSESPLGFSNFHIYVCAAFLIKFSSDLKQKDFQEIILFLQNPPTSHWTDKDIELMLSEAFIWSSLYKNASAHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEI9</accession>
    <name>G3BEI9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1774-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116635</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689768.1">
        <property type="nucleotide sequence ID" value="XM_006689705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEI9"/>
    <dbReference type="STRING" id="590646.G3BEI9"/>
    <dbReference type="GeneID" id="18248379"/>
    <dbReference type="KEGG" id="cten:18248379"/>
    <dbReference type="eggNOG" id="ENOG502REZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061220_0_0_1"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="271" mass="30731" checksum="D4C59A3CE3A09F3E" modified="2011-11-16" version="1">MSSNNDVYQHRVVSIGSLLLSAYGNVQLLFNYGKLSGEISTTPFSNFLIFMIVYWAVYYLVQLVYLNRVVSVNVDSSETNALAITHNLISFNTFTFIWSLLFRFRWYVVSEIVVIIELFVILNNYLNYKIYAFKPLKNFLLINLTNGSLPLSWIFFVLFWNGALMVHSTGFVARVLANIFIWDFLIIGVVFLTLFNDYTVGFSLSYLVLGMALNQLFTKFVALQWIFGFIISGLLLVISVGTILLKPKLKDQIVVQEESVGSATAPLLGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEQ8</accession>
    <name>G3BEQ8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136459</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689167.1">
        <property type="nucleotide sequence ID" value="XM_006689104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEQ8"/>
    <dbReference type="STRING" id="590646.G3BEQ8"/>
    <dbReference type="GeneID" id="18249975"/>
    <dbReference type="KEGG" id="cten:18249975"/>
    <dbReference type="eggNOG" id="ENOG502S0U7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026644_0_0_1"/>
    <dbReference type="OrthoDB" id="4094935at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV59953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="584" mass="65462" checksum="1D9BDBE9626A00A2" modified="2011-11-16" version="1">MSSRLQISETKPSRSASVSRKFQPHFTGPSVSLPPIKHFQLDYILKHVLKDESQQTVDCLVDVSSRYRKDLKKEIRLKLSIEQRLQNKNIEVAKRAHSIDTGLQNEITSISKTLYQASVSRDPAGATSERSNNLDVEVLQVVQMAEEISPKFFSITKKAAKIDVHLNGSDALTKKGSSQRAKYPLLYQFFHPEIPEVKKDKSAPPQTPSQTPSQNSPPVSAPLSYPRPESNEHHNLNTLPSSEQPITIDDKPMDPKAFDEFMAQTLSNYRNQQSKRYAGTDIFMEEQQRLYDSTELYNGTHFSGSSATSSAFHQYQDPIGLLYVMPSISAKSAATVTENFQTSHFKKLRINGSPITSESFRKRSLVPEDCECKSDRNVFNKPLEATASKSSSASISTEEDVHIEPLIVSDSSDSDSSHDDNAEEPLSVATNEYYSSLHDDYRSKKKKQKRRSLQKRIPSVRAFSPTPKHEPSHHILKPKASILKPSVYKDVSRASKPSKSLQESPDSKVWDRESSPPPRLPIINNDTVNSVNSITALGIIVREDSSDAQSENDRVVEWNGLPEESAVQKNDSIKSLDRLRSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BET7</accession>
    <name>G3BET7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metal homeostatis protein BSD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_127970</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689804.1">
        <property type="nucleotide sequence ID" value="XM_006689741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BET7"/>
    <dbReference type="STRING" id="590646.G3BET7"/>
    <dbReference type="GeneID" id="18249271"/>
    <dbReference type="KEGG" id="cten:18249271"/>
    <dbReference type="eggNOG" id="KOG4812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041193_1_1_1"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44654" checksum="46FF3D023F0788D2" modified="2011-11-16" version="1">MGHKYNQIESSEGLELKDLGNIENHGLLESFNPPLEDDSSVSDADDGRLVSSHSSSPPSTGASEIDRNIHNAIRNEGASSHYDVAVSGEAAPEHTAGSSSNSGGSEPDLENQLPHIRLTRTQRVMNVLQHLVPIKSTYDRISNGLATGRMQPNVPGRFIGQGTDGVFRNLMAKPDTEYNGAKNETNPPTYEEAAADSTPEYWETSVIAPIYEDEVFVEGLPVGNIANFVWNMLVTVAFQFVGFLLCYLLHTSHAAKHGSRAGLGVVFIFYGWNLVPSNFGSADKLPDRYEPKNPNNYNIDKNTAIDDAGVDNYASDLYSHQADETVSTTPYFAYGLIAFGLLVICKALVDYYRVKQMEQVILHPPGSEYQTNTITSTTTNYENENHNDNEIDDNGPTWTQSELSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEV0</accession>
    <name>G3BEV0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_111367</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BEV0"/>
    <dbReference type="GeneID" id="18246272"/>
    <dbReference type="KEGG" id="cten:18246272"/>
    <dbReference type="eggNOG" id="KOG1835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002778_0_0_1"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1734" mass="200746" checksum="B74AAEB977E27EE9" modified="2011-11-16" version="1">MLNWSNDTFLECYNSIKYQDHSRIDEQLVKAIQNDLNSVLVTPPNDESSKSKLIDNKSPTQFTNGDKLKLNDMFVENAIFLSKELGLNELATAEVLFYSSRDGIDNGASFIDQGRSAFFKRYQYILNILGYLITSRQLHLLTSDFNNFGSNVLDSFSKIYSIINNLNDLINKNTVTNSLNDVFIQTIEYTKTELFNCHELLGQILYNMIQYYFEEYGTVKFYKQIMTHLNSNVDDNDSIILHYLPGVFAIFDSLDKFNDQAVNELHKTVTNTLTDDFKLISLSPDLIDLSNSKLKSYEILMDFVFLTNLIPWCKETGNLEMFHFNEDILNYIQICLNYGVLENLLRFTSATSNLETVKLFEVNNLCEFRSLLQTNFPELSVLKFSKLNDNNAQSRFNLKLEVSSTFKEDLLPFYWHKFFSNFIKNVAIVLTQLRDSEEDYLLSSINRRQRVRDKGEKDSNNELVDGSSKDSSQALEKNIELDMEDMYTRADLERFYLSFVYTYKNRPNLCALIWEDGDTNNELVGFINWGVNNNSSPFITATFCLLLSSLTCKEDALSTIKIWENLINNNSNLKKSDYSKISMDSIVDSLEYYLNSLNENFENDLNDQIRKKQKGQEFLLSNALNNNHNSNKILIELSEDSMIFISGFVLLISSLVDNLSDDSERSKEIRQSMFNRFKPIILGFLKFDNLIMNSRILIGSNDFPLILVNENNRSTLINLMLNLLSSFNDPHAEDLELRYEIWDIVDKWMFHQLIDNNSSSRSPGVIDHHNPSPSEKIRLQKNTISIKNAFKTNLVDLPNILNFIELITNLLNSPENPSRINSKLLYPANLGNGYRFNNQTGIWPYIEFITLEVLGSSTKIKHSLTRVNLQNNLISLVLGSLNSVDWEFLDDILPNVSQDFKVESLFDASLTYDQFIKLHHSIGVMNYVFDEKVYKSIIEIILKEEDDTLVLSSLKIVHKLIKLQDIFAIMVSRLKANEQPKPTLPSTSLLSVIPALNTYYPSNFNVIDFLKVLSSNVALVTKFGLLIGTDNNKIVSLCIDLLTKVNRRFLDLNKDETLLIKNKLLTVFASGPESNQLRYSIINQFTDGDEDIKFKILNFLVEDLAISKGSPCFAHHLLGYTVKGNYLVINEDDSKLFIRNLTEHLVLSLSMVSSVDFNNGINIIEYNYTRMSSLVLQILNRLCHFPVSSLVTLQLLRDFESDEEVSFFETLLSYQTKIDHTTVWYNVRFNDDLLKENDFILDKESLLTFFEFFKMRNLMIQYLTVEFHHLSQQGSIYKKNQYLDKLINGDKFLNESHQVLKFLDVLNFKFSNFEQFNYQKFSKWNLSLLFKEVKSEDNIFNTDILDKLETITNNVEILDMKDFLVKFIVNDDLKALQLNYLHSWVQLIEVIINDGKLSKEQNQNFILEILSSILPKINEFFEKDIKFSEELISLCVILFDYYEEDNLFIERLLLLFSTCIKGIASSNSTIELRNDLYIIMNNFLQKSFKNNSETILRKLTDILEKTDVKFFEIICNDSIVSEGSIRITSMIFLESTIHLFNHFNNSFITDQLTKNNSLLLIIRSIKRIDEILDNELKEVSTILYELINFNSIINLLIRIGQSRLGSSYLIQSELFSIIKNLNILKVDPDLGMNLRINEINSVNLSLDSNYSFINYFQFLLPVFKLISVLLISMGPSYKPSKIQGKELLAHFGKLRNSIIKKDILINENKIKYQYEGELDELMNQFVLIDTLVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF17</accession>
    <name>G3BF17_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_95456</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF17"/>
    <dbReference type="STRING" id="590646.G3BF17"/>
    <dbReference type="GeneID" id="18250504"/>
    <dbReference type="KEGG" id="cten:18250504"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="192"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV59988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="364" mass="39397" checksum="12918E0B32B9DFC7" modified="2011-11-16" version="1">MSYPTTIQALGSSDPVHWSQAEPIKYEPKPFMDNDVMIKIHACGVCGTDVHTLQCVWGPHRDASVVVGHEIVGEAIRIGSNVTHITVGQIVGLGPVSNSCGECELCLSDREQYCVRAVFTYDDVDFETGSVTKGGFASHVTANQRFVIPIPKHLPEEYAGPLMCAGLTVFSPLYKKLNGKKGQTVGIVGIGGLGHLGLKFAKALGAHVVAISRTLAKKHEALTQLGADDFVATEDDPEWANKYSHKLDMVLYCGASMDNLDLNAYLRAIRPGGQWVTVGVPNGSTMVPLHASGIVSNDVAIKGSKSGSGTEAVKMLKMAADHQIYPIIEKLPMSVKNYTEAMERLGKYDVKYRFVLTGIDQYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFP2</accession>
    <name>G3BFP2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_99597</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="17">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFP2"/>
    <dbReference type="STRING" id="590646.G3BFP2"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031900_2_0_1"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000436">
        <property type="entry name" value="Chromatin modification-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16 17" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="127"/>
            <end position="210"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="219"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
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            <position position="221"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
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            <position position="232"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="237"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    </feature>
    <feature type="binding site" evidence="15">
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <feature type="binding site" evidence="15">
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            <position position="264"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
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            <position position="218"/>
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    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
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            <position position="229"/>
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    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
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            <position position="233"/>
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    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
        <location>
            <position position="241"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV60067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="277" mass="31577" checksum="E077F8276B2A01FF" modified="2011-11-16" version="1">MDTTAVIDKYTQDISNLPLEIRYIFEEIHNKDIQLMEARRRYQAKDSQIHKLIKQSGTQAKHPKEPQVYAKIEEDLQLVEKIQKEKILLANTALFLISKHLFNFETDITKLERDELIPAIDNVYEIEGGPQDGTGGVGRAYSDVSASATPRSTLSLTPGVESSALQRKAQKRKAMMKAGVRPYKRSRMDDDDDDDESQPDTPGRHDGPGGDDADNTLYCLCQRVSFGEMIACDNEDCRFEWFHWQCVGITSTPKDNVAWYCPDCAPRMEKRKKKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFS6</accession>
    <name>G3BFS6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116795</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFS6"/>
    <dbReference type="STRING" id="590646.G3BFS6"/>
    <dbReference type="GeneID" id="18248445"/>
    <dbReference type="KEGG" id="cten:18248445"/>
    <dbReference type="eggNOG" id="KOG3189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
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    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
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        <property type="entry name" value="HAD_sf"/>
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        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
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    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="18"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
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        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
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        <location>
            <position position="138"/>
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        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
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    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
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        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
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        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
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        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
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        </ligand>
    </feature>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
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        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
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            <name>Mg(2+)</name>
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            <label>1</label>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="251" mass="28549" checksum="95FF26BA57A9FE41" modified="2011-11-16" version="1">MSFAHKENPKTLVLFDVDGTLTPARLEVSDEMKQTLKKLREKVVIGFVGGSDLSKQVEQLGATVLEDFDYCFSENGLTAYKLGKELASQSFIGWIGEEKYNKLIKFILKYLSEIDIPVRRGTFVEFRNGMINVSPVGRNASTKERNEFEIFDKKANIRTKMVEALRENFADFGLTYSIGGQISFDVFPTGWDKTYCLQHVANEGFEEIHFFGDKSYKGGNDYEIYTDERTIGHAVDSPADTIRILNEIFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW30</accession>
    <name>G3AW30_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_132693</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW30"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_906131_0_0_1"/>
    <dbReference type="OrthoDB" id="10643841at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="307" mass="33961" checksum="E075383030AD21ED" modified="2011-11-16" version="1">MILSEANKNFATISITALISAATAKIVDCVSAGEEVSSTDLDDGVYYFQLPSNSSAFFSYNNDNNYTAKFYYAVVGNKVYHTYIRTGGNIIAIPAEELYHTENDVVIYSVEKDNNDNVSSWQLSPNDVEDSAYFSESTLQENRNWDRYAGSSNISSEQPTRNYGSVFGTTSSIDVLGASSTSQHSHDGHENDDDDGESDSEDDAVRNKSKRNLRHKLQMLKLEELVAKDNADDEADDEADDEADDEVEQVQLTGYKKYSKVRKRDRSDVIVNLYYQSGETFMTANYAVVDQGVASIAATTIISDSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW41</accession>
    <name>G3AW41_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_100734</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW41"/>
    <dbReference type="STRING" id="590646.G3AW41"/>
    <dbReference type="eggNOG" id="KOG3203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_1_1_1"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="174" mass="19999" checksum="7EDC3FF2107AA31B" modified="2011-11-16" version="1">MSQRIGNAAVALTRVWHHVDVAGDHRTLGRLASSIAIALQGKHKPTFSPNRDHGDYVVVTNCAHLKITGNKLQDKTYWSHTTRPGSLNLIPMQRMIDNKGYNEVLRRAVKGMIPKNKLRLVRMDRLKLYDGDEHPYKQNLIAFADEAQEVREKIANLEQSEKEKQELREKFFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW52</accession>
    <name>G3AW52_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112184</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683711.1">
        <property type="nucleotide sequence ID" value="XM_006683648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW52"/>
    <dbReference type="STRING" id="590646.G3AW52"/>
    <dbReference type="GeneID" id="18246390"/>
    <dbReference type="KEGG" id="cten:18246390"/>
    <dbReference type="eggNOG" id="ENOG502SX3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095379_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="176" mass="20985" checksum="120C5852821FE0D6" modified="2011-11-16" version="1">MLWWNSTKETQEIEKELPEDLKEFFQKNNPDDRQYNKYKLTPQQIMVNAKLKKISQEYSYDLETYKRKNSIRNVSITNCAELQLKVVDCFKSLNFTSIDNCSKQIKANKNCVEIQSKAFNKMFYNDCYSTQHCDKIRFLVDHLFTSNFGQYGENMNEETLAKFDKDLDANFSKVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWI2</accession>
    <name>G3AWI2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LrgB-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112265</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWI2"/>
    <dbReference type="eggNOG" id="ENOG502QQ63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024337_0_0_1"/>
    <dbReference type="OrthoDB" id="2502820at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249:SF0">
        <property type="entry name" value="PLASTIDAL GLYCOLATE_GLYCERATE TRANSLOCATOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PUTATIVE SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="67698" checksum="6928955789FB111E" modified="2011-11-16" version="1">MLKDILLGITYGVYYSKSHLFRSYVVVPVGVVIEIMILYGLNQFIVNILKITFPASVLGMLINTVILCGLSTATKVHKGFDMVLNRYLRMIEPSMNFSLKWINIFFIPSFIILPLSQPITIIEVLKIAGVFVVGWCALMLINIYSIQLIKILMNLNRKEAAKETTSDDDHDEEFIKNTSEGVSEMAGGDLRQVQTEPYDLGRGHHENLGIGSSSATETENIELMDMDNPFIMRPERSYVKQNSTPISMASEENEFGVETVLPSRMSMKSAPSQVDVPPGSSSSSSKEKNTEIDSTTIFITNYIDWVLYFLLFVASLPLFYTPYHIFLPFHFSVTIFSYFVALLIPHKWPVTKRFAHPILVSTFLILFICFISSLIYHHTAKGFLDDLKYYKTGKNYLNLFSKAYLFDNGETNKNPQESITKYPIWPGCGDFLSSMMDVSIVSLSLPMFTHRRDFIKNFWIMIPILMSIALTFLLYPLICYNIGINPQRSIGFIGRSVTLALGNPLINALEGSISLMAVCTILSGICGVLIGDSLFKFLRVKPGDYVTRGVSLGINCGAIATAHLLDSDPRAASMSSLSFAIFGTVMIVFSSIGEIRNFVHAMVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWJ2</accession>
    <name>G3AWJ2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112273</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWJ2"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_1_0_1"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33178" checksum="009475EF235492BA" modified="2011-11-16" version="1">MPPPPIVLNAQAVSGITGSISIACWIIVFAPQIYENFTRKSSEGLSLMFIILWLAGDLFNVLGSILQGVLPTMIILAIYYTFADIVLLWQCLNYNHKSQADLIHLSPASPFDGDTIEHVLSRDNEDEEDTDKPPSSPVKNFLFKLLLVTLVFGSGLVGWYISYVKNYYKYKHPEEPKLVFDPLAQFFGWLCAFLYLGSRVPQILLNFKRKSCEGISFMFFLFACLGNLTYVISILSVDVSRDYLVINSSWLAGSLGTLFLDFTIFVQFFIYNEEIQEYPSSESGYGAIDDINDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWL9</accession>
    <name>G3AWL9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_128954</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWL9"/>
    <dbReference type="STRING" id="590646.G3AWL9"/>
    <dbReference type="eggNOG" id="KOG2206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010129_3_2_1"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="438"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="628"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="737" mass="84717" checksum="2FA478129D8BE255" modified="2011-11-16" version="1">MTKPVLELLHEDIIPSVVQNIRTAGALRANDIGFHKTLDSNLATRSREPDSSELDIKNDTELEGSNWKVITNTLDILFERADVLFDEIENKGSIDNSKTFTYLEESNNVIKDESKVIGKKMEKPQLEFSIPVDNSELNPFKPKLTSKPNALIPFEESVKLVQPENSDGSDIVDPPFYPHPYEYEIDNQPYRNSIISKCDPIPSNPWESTNAIWIDQPEQIDELVNELSNSSEIAVDLEHHDYRTYYGLVCLMQISTRKKDWIIDTLALRDDLQKLNVVFTNPQIVKVFHGAFMDIIWLQRDLGLYIVSLFDTYHASKKLGFPKFSLAYLLETFAKFKTSKKYQLADWRIRPLSTSMLAYARSDTHFLLNIFDHLKNKLIDQGNGKMQSVLHDSRLVAKRRFEYTKFRPLKGTSLVTCPVMSSNPLEPFLPIVVQYNIPYHIKPVVEVLYNWRDNLARQFDESVRYIMSNQALALLATLSRPVDPKKILSIPTFITDFIRKNADELAFLINNILDRLENSDWELSEAMKPHTSTTKYPSDNQINKTTPDSIKLQNEIFDNIWNENNQLLKSSKLFNEVQEHILSVKFSNGLVSITMDEAVKRVSAKNEEFRKIYDFKKPKILEPRIQSMTDIETPTVQPEVEIPKQSVDESAGEHKDDIITLRKPKRTKTRGFKRQSDDGEPVFDYSGADNLMNSNKKSDNARHKKKKFDPYSKTSVGPRGARSGNRVHGGRSTTFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWP7</accession>
    <name>G3AWP7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_91759</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683845.1">
        <property type="nucleotide sequence ID" value="XM_006683782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWP7"/>
    <dbReference type="GeneID" id="18250109"/>
    <dbReference type="KEGG" id="cten:18250109"/>
    <dbReference type="HOGENOM" id="CLU_1447487_0_0_1"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="187" mass="20972" checksum="4F2A8C82CEBDDA76" modified="2011-11-16" version="1">MGFMNNFASWIADSAISFAQVVLFPWQKFVWEPFVYTFRIVEYTAGSVLLPVKLILGVKQIDVPKTGEFVVVMVQYVIVSGIVGTVVGVVLSKYLIILKQLRIGEPDLRKQRESTHLTPSSEDKLSQKESIKPEAPELNTNEWSRSEESNFDTLFERYLNETKLTSVGGNVGEHKSEGGSGTKPKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWS6</accession>
    <name>G3AWS6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="5">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21 22">mRNA-dihydrouridine synthase DUS3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">CANTEDRAFT_100359</name>
    </gene>
    <organism evidence="31">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="5"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWS6"/>
    <dbReference type="STRING" id="590646.G3AWS6"/>
    <dbReference type="GeneID" id="18245376"/>
    <dbReference type="KEGG" id="cten:18245376"/>
    <dbReference type="eggNOG" id="KOG2333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_7_3_1"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="29">
        <location>
            <begin position="247"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EGV66604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="613" mass="69761" checksum="B45CEF988983A8C3" modified="2011-11-16" version="1">MTVNTKRPNDSEVDSEAKKVHIDLRDKGWAAIKAEFVIKNEEAADLYINDDDAEGGDRDQVQETTGKKKKKRGQNKNRDLRQEHGAIRLCTSLVDPDNAKECRFGAENCRSSHNIEEFLASKEPDVEGICPVFDAIGYCPAGLKCRWLGSHYDKETNKLLKDLAKIEVNQEPRELNRITNDAKIALQKKKYEFKTATKMISYLDSQVKNEAYMKNLEEKKDNQAEFVEVPFRVAEKKRLNFKNAKIVSPLTTVGNLPYRRLMKTLGADVTYGEMALTVPLLQGTNAEWALPKAHKSEYPGFGVQFAAGKHWSAAKAAEIIYRETPNVSELNLNCGCPIDLLYRQGQGSALMEQPSKLMRILKGMNYCSGDIPVTVKIRTGTKDNKNTAKSLVGRLLEENEVAAITLHGRSRQQRYSREADWGYVGEVAQVVQDWNNRKEENKDMSDTQATQFLGNGDVYTFEDWYAATNTPGIDSVMVARGALIKPWIFEEVEAQQYLDKSASERLDILRTYANFAVEHWGTDEYGIGLARRFMCEFLSFYHRYIPVGILERLPPKLNERPPKWKGRNDLETLLGSSDYQDWIKITEMFLGKAGENFHFTPKHKSSSYEQSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWU9</accession>
    <name>G3AWU9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112336</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWU9"/>
    <dbReference type="STRING" id="590646.G3AWU9"/>
    <dbReference type="GeneID" id="18246475"/>
    <dbReference type="KEGG" id="cten:18246475"/>
    <dbReference type="eggNOG" id="ENOG502QQBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033072_0_0_1"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="1">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="2">
        <location>
            <begin position="223"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="425" mass="49504" checksum="446D89F4D036AA81" modified="2011-11-16" version="1">MLAISLVSRARSMTLACPTLQPIRHISFLKRLLVLNDNTDSDSSEKIYPWDESPYEDLRTRAAYIRSTALCPVTEKPVDYVCPISGIPTHHDHQAWANDTEYHSKEKYELLKKVNLYEHDLRSGRVFDEFVFPGAQEHDFMTSLSNWDSFFYTRDFNPMNTEFNMAAATKVLTYPITIASVLHRLTPYFLQPKGPLSLEGLKSVAALKYSLYPPYQKHEGANVYKERPIRIFIVGAKMEAMLPGYVWKQFGYLFPESKFEFHFIGPECYFDRATKSFSATNEPNGRALVERYDEQITLHYHTMYFHELYNFGDLFPFDPYLDVFFMFHPGFQTPDKPHWDKSLKGLLESKCAVYVTGYHQTDTLRERAWLLNHPLAEEMDILMDQTQNVFGSTKIDLVDSNPTETFQANDEIFAFRGKRYHAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX18</accession>
    <name>G3AX18_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_100638</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX18"/>
    <dbReference type="STRING" id="590646.G3AX18"/>
    <dbReference type="GeneID" id="18245400"/>
    <dbReference type="KEGG" id="cten:18245400"/>
    <dbReference type="eggNOG" id="KOG3242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064761_0_1_1"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="217" mass="25062" checksum="B1E5620B401FD295" modified="2011-11-16" version="1">MSAQRLIKNLVNSTRVMKPSKPLVWIDCEMTGLNINTDHIIEVCCLITDGDLNVVDDCYESTVYYDESVLQKMDAWCTKTHTESGLWNKVISNPDRTVSKVQDELLAFITKYVDIHKGLLAGNSVHMDKFFMMKEFPKVIDHLHYRLVDVSSLSEVGKRHNPKLMSVQPRKKKDHTAKSDILESIEQLRWLRETYLKSEEESRDTIDKLSRARSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX41</accession>
    <name>G3AX41_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_117852</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX41"/>
    <dbReference type="STRING" id="590646.G3AX41"/>
    <dbReference type="GeneID" id="18248601"/>
    <dbReference type="KEGG" id="cten:18248601"/>
    <dbReference type="eggNOG" id="KOG3142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103851_1_1_1"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="175" mass="19149" checksum="09A525BB05DB5852" modified="2011-11-16" version="1">MSNFISSFPLAQFSERLSLDRIRTDVGSLQSSISKLRPPQEFFDVRRVSKPANFGEVQSRVSYNLGYFSANYLAIVSILSIYALVTNLLLLFVILLVGGGVIGISRLGGNDLVLPFTRLTTSQLYTGLFVVAVPLGFLASPISTMMWLIGSSGVAVFGHASFMEKPIETVFEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX70</accession>
    <name>G3AX70_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_112442</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX70"/>
    <dbReference type="STRING" id="590646.G3AX70"/>
    <dbReference type="GeneID" id="18246521"/>
    <dbReference type="KEGG" id="cten:18246521"/>
    <dbReference type="eggNOG" id="KOG4097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096618_0_0_1"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV66703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="156" mass="17135" checksum="C30F512B4E8038B9" modified="2011-11-16" version="1">MSRLGLGMSKTALKSSAVYRPTLVRGIKTIPQPPGYIVGTVNDAYVPPKPNKTHGSLHWAREKVVTVAMIPFIGYPFLAGTTTFVDASMSGLLLYHCYVGFQSCIIDYIPKRVYGAYHNYAMYLLTFGSGVAAYGIYELEKKEGGVTTIISKLWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXR6</accession>
    <name>G3AXR6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_118183</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXR6"/>
    <dbReference type="STRING" id="590646.G3AXR6"/>
    <dbReference type="eggNOG" id="KOG0547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017516_1_0_1"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000357">
        <property type="entry name" value="Mitochondrial proteins import receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000374">
        <property type="entry name" value="Mitochondrial proteins import receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="66351" checksum="EBBE1737DEDAA667" modified="2011-11-16" version="1">MSALDNSGSFLARNKTLVSIAATVAGISAVGALYYYSQQGPTPSPEDSTASKKKNKKKKKSKPEDSKDTSAAPASPASSKIYPVGKDGLPDLSEATISNLTADQKSEWALALKEDGNTEYKAKNYKEAVAFYSAALKLKVDPVFYSNRSACYAALDDHENVVKDTTEAIKLKPDYTKCLLRRATSYEILEQYPDAMFDLTALTIYGGFSNKSVEQVLERVLKKHSVRIVEQNIKTRVLDLPSASTTGSFFGAFVTESNPEGISEESTGNDKLLFDAIAKINSNTPEGYEEADKLIAEAVSGYDAEGLKADSDNAAKASIAYEYAATFKFLKNDPLSAAVDIGKAVSLKPRSRTYVIRALINADKSSYEDARNDFASAAKMDSNAGDAYYHLGQLFYLTNELDKAQENFEKAKKANPQNVYAYVQSACITYKNGDIKEAEDKFTEAKLKFPTSPEIPNYYGEVLSDRGDIQAALKQFETAARLQKALPNYSVGALPLVNKASLISRENFNKLDEAEELLVEACKLDPKSELARISLAQLKLQKEQVDEAIVLFEESSNLARTIEEKVQATSFAEATKMQKRIKADPILSEKIAEVMRQSMMAAGVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXR9</accession>
    <name>G3AXR9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_96792</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXR9"/>
    <dbReference type="STRING" id="590646.G3AXR9"/>
    <dbReference type="GeneID" id="18250631"/>
    <dbReference type="KEGG" id="cten:18250631"/>
    <dbReference type="eggNOG" id="KOG0544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_12_1_1"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="112" mass="12070" checksum="98C97ACB4A632F57" modified="2011-11-16" version="1">MSAPQTTQIEFLQEGDGKTFPKQGDLVTIHYTGTLENGKKFDSSRDKGKPFQCTIGVGQVIVGWDTAIPKLSVGSRAKLTIPGHEAYGPRGFPGLIPPNATLLFDVELLNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY30</accession>
    <name>G3AY30_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_112618</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY30"/>
    <dbReference type="STRING" id="590646.G3AY30"/>
    <dbReference type="GeneID" id="18246606"/>
    <dbReference type="KEGG" id="cten:18246606"/>
    <dbReference type="eggNOG" id="KOG2981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027518_2_0_1"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV66160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="307" mass="35157" checksum="1EC51280EB2EF95B" modified="2011-11-16" version="1">MSIRSKLSSLRDYLTPINNTSNFTTTGEISPDEFVIAGDYLVYKFPTWEWSSAPSKLQKSYLPPDKQYLITKHVPSHERAYTYLGIDATLDESEEELEDGWVKSHKISESAKSSDSIDDAKPSEIQDNDHNDNNDIDDLIDETAELELAEDEFEDLSKGNHSSLRKYDLYITYSTSYRVPKLYLVGFSSSGIPLLPKQMFEDISSDYRDRTATIEKLPTSFNTTSVSIHPCKHASVMRVLMEHAKQSQLKRKLKDRDEDDESEDVKPKDEDEDDELGVRADQYLIIFLKFIASVTPGIEYDYTMEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYN1</accession>
    <name>G3AYN1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_96973</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYN1"/>
    <dbReference type="STRING" id="590646.G3AYN1"/>
    <dbReference type="GeneID" id="18250644"/>
    <dbReference type="KEGG" id="cten:18250644"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_5_2_1"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000001">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="114"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="305"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="614" mass="68442" checksum="72FAE0AE0B11F071" modified="2011-11-16" version="1">MLCMRRLYSTKSVHTHTIKTPVDINAAIASLKPKVTRLSNDGPIECDLTGFQLLNSPIFNKGSAFTKAERKAFGLTGLLPSQVNTLDGQVDRAYRQFSYLKSPLAKNDFCTSMRIQNKVLYYELVRRHIREMLPIIYTPTEGDAIASYSDRFRKPEGCFLDITDPDSIDERLAPYGEDKDIDYIVVSDGEGILGIGDQGVGGIRIAIAKLALMTLCGGIHPGRVLPVVLDAGTNNQKLINDDLYMGNKFPRVRGEEYWTFVDKFITAVKKRFPNAVLHYEDFGVSTGRIMLHRYRDALPSFNDDIQGTGAVVMASFLAALKFSNRRLQDSRILIYGAGSAGLGVADQIVNHMVNIGMEREDALSRIHTMDRRGLILQSFPDSSEGQIKYADPDADWENVDTKSLVECVRHVKPTLLVGCSTQAGAFTEDVIKEMYKHNSQPIVFPLSNPTRLHEAFPVDVMKWTDNNALIATGSPFEPVDGYYISENNNCFTFPGIGLGAVLSRCTTISDTMISAAVDQLSSLSPKMENPKNGLLPRLEEIDEVSAYVATAVILQSLKEGNARVELETNPDGEFVEVPRDFKKCLKWVQAQMWKPIYRPLIKVEHVPEIHTFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYP6</accession>
    <name>G3AYP6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="7">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112776</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="7">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="7"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYP6"/>
    <dbReference type="STRING" id="590646.G3AYP6"/>
    <dbReference type="GeneID" id="18246668"/>
    <dbReference type="KEGG" id="cten:18246668"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="10">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="462" mass="49008" checksum="5A38ADFAA77D1F20" modified="2011-11-16" version="1">MSLIGSTRTMALRIGSIPVTKRFMISSYQLARFYSSKFPNHVVINMPALSPTMTQGNIITWHKKAGDQLEPGESIAEIETDKASMDFEFQEDGYLAKILMGDGSQDIPVGKPIAVYVEDADSVAAFEAFTAADAGDAPAPAASKGEAKTEEAAPSSESTSKADKPVSTSVRTPTDRIIASPLAKTIALEKGISLKGIQGSGPNGRIVAKDLENVEAPAAASATATAATSTYEDIPITGMRKTIASRLLQSTQDIPSYFVSSTISVTKLLKLRSSLNATANDRYRLSVNDLLIKAIAVAALKVPQVNSAWLPGEGIIRQYSNVDVSVAVATPTGLITPIVKHAHSKGLSSISTEVKDLGKRAKAGKLSPEEYQGGTICISNLGMNHAVNNFTSIINPPQSTILAIGTVDKKAVPSDVNEQGFVFEDVITITGTFDHRVTDGALGGEFMKELKQVIENPLEMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYR7</accession>
    <name>G3AYR7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_102442</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYR7"/>
    <dbReference type="STRING" id="590646.G3AYR7"/>
    <dbReference type="GeneID" id="18245551"/>
    <dbReference type="KEGG" id="cten:18245551"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_12_1"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="184"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="729" mass="81969" checksum="5122E9660CBE9F80" modified="2011-11-16" version="1">MPNSKSQRSNLSIAIQKAEEEELSHNNHNHLIHNSPFASGSIRQEQNNDSKPSISNSDENTLPNQPFLPVIHHSNPTVSTTSSAKVKSFKPNLSPLKTKFSDGDFKRGGFTPGTRFDFGSDGEEYKRKPEDTNENESYNEDDSDEDDDSDIDSVHPENEEDMKDYVPGGYHTCYIGENYKNGKYTLVRKLGWGHFSTVWLARDNDKQCHVAMKIVRSAKHYTETAIDEIKLLDKVTTSDIHHPGHEHVIQLLDTFTHGGPNGVHVVMVFEVLGENLLGLIRRYKHRGIPVVFVKQIAKQLLASMDFLHRKCGVIHTDLKPENVLIEIGDVEQIVKMVEEEENQAKMQKRLQRTKSKSGHNSFLGAPSISNPNTPRIDRKASNPSFKTPETSSSDIKSINNSPSIGRNGRRSRRQTLITGSQPLPSPLRTFNKSFTSVYALSNSTANTPVKSFTNESDQSGVALSELTNPNTDSSLNKVTSNRDINNSLSSLSISHKFEDNASNLEASFNESINENSFMINDDELISVKIADLGNACWVNHHFTDEIQTRQYRAPEVLLGYHWGSSADLWSFACLIFELLTGDYLFDPREGKAYSKDDDHIAQVIELLGPFPRQMLKESYYARDFFNARGELHRIQKLKPWGLKDVMVEKYKFSVSDAIEISDFLLPMLTTQPEQRADAGGMINHPWLSDALGLENVVLERPVGGSGEDIPGWSKEISSSSYNSNKFYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ35</accession>
    <name>G3AZ35_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7877 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_133428</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684569.1">
        <property type="nucleotide sequence ID" value="XM_006684506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ35"/>
    <dbReference type="STRING" id="590646.G3AZ35"/>
    <dbReference type="GeneID" id="18249704"/>
    <dbReference type="KEGG" id="cten:18249704"/>
    <dbReference type="eggNOG" id="ENOG502QQT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043834_0_0_1"/>
    <dbReference type="OrthoDB" id="5354116at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057199">
        <property type="entry name" value="DUF7877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25289">
        <property type="entry name" value="DUF7877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7877" evidence="2">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="532" mass="60177" checksum="C0246329A94E5126" modified="2011-11-16" version="1">MTAEAKKDLVQLIEDVFSVLERADIETSILSLDFPSNFYEADSTKIIDSLRNFFDESGDSGSTTTILKKNDSKEYTNLYDIYHDIKVASSLKIRNLKIGSKDYKAIDFFYKFSTEILLRESSLLKTALFSYSSENDTPSELEEQVASDFEKIGHSYSVSNGEVATYMSEMPNPSASSLIPSFGYATSSAPPTIKQPLFTSQLGKSELDPRFTLIPEPYNLVKSIPLPKNVGSSSATFETLNAHVSKIPLPTNKPTTVLDNFLYITWYIIKAPEWLTYTGKTLKPTITSNLFKDANKNEFRLANSNNESVKSFAPKFDSKGTGVSEILKNNVWLNQIGYKKIDEIRKEYLKNTGKEIVTDQNKEESDSKSSLKVETKEAVDDDENVYFEDYDESKTIEIEKVLKWDPTEIDVLKSLKKDNKQITGSAKHLQQLISKELLKLNKLRQERFLRSNFNNVLPATLAEKKLYKKITKLISLSINLHKVAPSDLPLEFSKRVPVLMTDYSGTLPSLPASKSRSTRLPNIRGPYKKKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B032</accession>
    <name>G3B032_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Gamma subunit of Oligosaccharyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113031</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B032"/>
    <dbReference type="STRING" id="590646.G3B032"/>
    <dbReference type="GeneID" id="18246793"/>
    <dbReference type="KEGG" id="cten:18246793"/>
    <dbReference type="eggNOG" id="KOG2603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052855_1_0_1"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442668" evidence="10">
        <location>
            <begin position="17"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="335" mass="37811" checksum="6C2FBEFA84BCA84F" modified="2011-11-16" version="1">MKVSLIQLMMGVMAYAACVLGGFTNEEMLAKVKKLGGKKVFQLKENNYEEFLNGPRDYHLMLVLSSTSSQFNCPLCVEIKPDYELVANSWFQDHPNGVGASSEGKDVYFLYAEFLNAKSLFQKLQLNNIPKAYYVAPSAASAPDAWTDELEEYQFFQGVHTELISIFLGDKTGHKFNVYVPVSYSKLGWTVFIVAVVVLWLKVFFKQFKVLLSSKLLWTVLSIITILLFTSGYMFNQIRHTPYFKQNPEGAVEYFAGGQQTQYAIETQIVSFIYGILSLLFVTLVKKVPTIEHPKVKLLATGLVTISIYAIFSVLLAIFGIKSPGFPFKFFKIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B037</accession>
    <name>G3B037_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_102627</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684992.1">
        <property type="nucleotide sequence ID" value="XM_006684929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B037"/>
    <dbReference type="GeneID" id="18245564"/>
    <dbReference type="KEGG" id="cten:18245564"/>
    <dbReference type="eggNOG" id="ENOG502RA02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156003_0_0_1"/>
    <dbReference type="OrthoDB" id="4022411at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12878" checksum="420D7644A24FD8B3" modified="2011-11-16" version="1">MTVLILNPEELKTRFPQSSESDTLRVRLIVQTLRFDYESNHIAIRSMSCVTPSSVKVWLHNIGKYDSQVVKKGTVIDVTGYFNGEDVDAIEISALNGSELTQENISVLQTISHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0X1</accession>
    <name>G3B0X1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_93060</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685636.1">
        <property type="nucleotide sequence ID" value="XM_006685573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0X1"/>
    <dbReference type="STRING" id="590646.G3B0X1"/>
    <dbReference type="GeneID" id="18250251"/>
    <dbReference type="KEGG" id="cten:18250251"/>
    <dbReference type="eggNOG" id="KOG4336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024798_0_0_1"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="9">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="10">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="546" mass="61189" checksum="5E908A32EFCDD79D" modified="2011-11-16" version="1">MDEKESTSSPAPTHSSASASGSTVPAGDTLGQRRRMLNDETLQLLNNPVSHYARTPMDFQVAKLIGIILETQGFSVSAEFLDELTDLALIYLHQTVDGIKKFTEIQRRTKPSLNDIRYSFNLRDIDYSDLYRSGLVGKKVYNLSKVHIDAVNQESLQKLVSLQQVSFEPESEPFFMNQTYEITSLVPRHVAKPNYIPSYFPDFPPDYTFQNTANYRDTLTDMEKLRVKLVQESRLTEKSLYNLIEEDVKYDTPMSEDTELDSIMSSEMETPGPRFEEHKPPELPEYADDADDNPDGIIQAEAKKQPVASEKPFDVLAYAQKRLEIKARRSQEIEQTRKKRAANIYLQAETYYSPYGTESITLEKQKEFDGLIEKDLHLAMVSVKAGMENQKLHIQEILAERAKLEKQREAAKAADTIEFGFNFNNNSIDSDSDSDADGEDMQEILFGTDTKENSFPTDRETKSPESSMPPSFTPSSGALAPESSIPGASPEPELKLKLNFSAPASTAFEAPEISSDDDEMDFDVLDGLGSPPPQMAIDKPSDGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1D6</accession>
    <name>G3B1D6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_130107</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685751.1">
        <property type="nucleotide sequence ID" value="XM_006685688.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B1D6"/>
    <dbReference type="GeneID" id="18249422"/>
    <dbReference type="KEGG" id="cten:18249422"/>
    <dbReference type="eggNOG" id="KOG1900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000429_0_1_1"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="6">
        <location>
            <begin position="106"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="5">
        <location>
            <begin position="664"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1348" mass="153876" checksum="610D65ECE89776CE" modified="2011-11-16" version="1">MAYISSTIKLGDPMLDSLQFQRETNPIKPSTRLPIDLDSVNDVSYKIKVPNFNELTPLKLSYKYITDLIKIDSMIPTDLYSDEKLNKVNNTVLDSYYYNAKGLGDFTKFDKIQQFNLPDKFFDEYNSSELITKMGLFPEIERSWIIVDNKLILWNYKAPQSSFNKSNQFLTIDQIRHSILSVKLAKPRPGVFVDDVNYILLVATPMDIHIYVVKYKKELNNLEIFDPSLSVSVQGLVVSNFVVSKKGDVFFTEGVNVWRLDYNNKASFIKNKCDKVCLTKSGFGIPSIFEDNSLSQSKTSGTSSKSQGSAATPAQNIAEVITQLEIDDEREILYSLSNKSIIRTYKLKDSQISSSNKITPSEMYRTLSSLFVDAGNFKSFSKFRIMNIQPIFARESSSVQLIAMTNFGVRILLKLGPQSFFQASNRLKLSVVNIKFPPSKELPTMNNELDSFTRSKQYISQLISSQQRSDLLKNTKFSKVLSPGVFLVVKRSRNADKLFVSTVNYGSLKKNNKLIEDAEFLKIDDNTFIHDIVQLTPSMNATNQPNGYANILASQYTKQPLRFAVLTNFGIQIYEFKTPDKILNSLNEEIIENFIDENGFEETCSTLLYLSCSYGHHSSSDLFKRKAQMLFSTCGNNSRLLDVKSNTSTSLLSQKETNDQVILSDRFYGTCLLISRIFRDYWNNNVFLALPNIKMNSLNQVDSSSIKDNLLIKGLSISKKQIEYFMGSIIVLIEFFVENGNNIQGLNAPNYSSDPTRVENEMCLRSEHIAFTSLLKSLDSMKEALSFLMVLIEETESNKSFDEILKFLTPTNQLNLLNLSFKDLLLPNDEVKNLIKDLLSSIINKNILKGGSIDLIASSLQGRCGSFVSTDDVLIFKAIENLTRAKNIGFRDNDLKFKCLKSAVLLFEQAYESLTLENVQNSVNIMLELEYYVGAVELLLKLANKLEKSNKQTDTKLTQLYDLVFNILTKIDMKVVKVTELNDTLKANDIMEVRNSAYDTCFISKDKRFHYEFYEWFIKQGVGERLLDIDSPFILPFLEEKAVNDVKLSELLWSYHAKRENYYNAASILYSLAISEFKLDLVQRIEYLSRANGFCNCTCPPNLRQKMIQLSALVQDLFDVSNIQLDVLSAIKSDNRINQANKQTTIDSLNFKILNLTDLFNDFTDPLGYYDLSLLIFKISDHRNPDDILKRWEYFFEKLFHKFLIGNKTKVPLYVIMSNEFTAIGSKLSSNDLVFPIDKLIKLISKNLHDAMEEDSSQAVPEGALVDMFIKSGVPYDKLYYVMRSLIENDSFEIYPGFVQFLRTNEMVYLIKQWFAKDKNLRNVISNVKIANLTDYTIASDPIGSALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1E3</accession>
    <name>G3B1E3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113695</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685756.1">
        <property type="nucleotide sequence ID" value="XM_006685693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1E3"/>
    <dbReference type="GeneID" id="18247088"/>
    <dbReference type="KEGG" id="cten:18247088"/>
    <dbReference type="eggNOG" id="ENOG502S3D4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648899_0_0_1"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="423" mass="47386" checksum="185621547DAE7E73" modified="2011-11-16" version="1">MYCVSIDATSCSCHDSTDIFPQRHPSVPAFPSQAGTTPSAPINKYRPINRTRSESDMSSASPPSDCSSSCESLNDIFSARDSIISDVSDASIPTYYESTIKCPEYSTLEEPLPSYVPTLESFGLCLVKLEFLTPYKSNSRAKWEPMMLELNSTQLILRELNCSRTLKNLVVGLFQARNGPQDKSHSHMCKNLGKFYDELKHNQMLFEPVSNRAEASSVLNRYGGDIACKLALHSSMVGVAPNAQEHVDKDSITLIPYKNTLRLRAEMYQMLVQTWSFAAMVKWCEELVVARDLCHNFDGSLAKRRTLPDYGVFQALNQNNLQDEETTNSVVINNFSFYVDGRYNMTEMSMINACLPKLKSYDNWSNLVLSNVEALKIHPTEGNIYVNYLKLNAAAAKFKPQEGPCRQFSIKSEGLVSLSPGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1T0</accession>
    <name>G3B1T0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_104085</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685330.1">
        <property type="nucleotide sequence ID" value="XM_006685267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1T0"/>
    <dbReference type="STRING" id="590646.G3B1T0"/>
    <dbReference type="GeneID" id="18245686"/>
    <dbReference type="KEGG" id="cten:18245686"/>
    <dbReference type="eggNOG" id="ENOG502S1KI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_2_1_1"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="151" mass="17051" checksum="7F15E781131A969C" modified="2011-11-16" version="1">MANASATNATKSVNPTSSNGITSLKKQVDDMKYLKYDSNGSNSLYAILRLHNIPYLVTKGDKIILPTRMKGVKVGDQLTFNNVTTIGSPNFIFNSENGVNPDLFEIKGSVVEITKEPYYEVYRKKQRCRRLKTIPVQNYQTILMINELKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1W0</accession>
    <name>G3B1W0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_120140</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1W0"/>
    <dbReference type="GeneID" id="18248755"/>
    <dbReference type="KEGG" id="cten:18248755"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="16"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="189"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="379"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="797"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="734"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="895" mass="100567" checksum="60AEB3A0596AAFCF" modified="2011-11-16" version="1">MAGSTSTQSTSSSVSAFISTLIPNLIIFAVFLLIFILLRKKQSRVYEPRTTVSTVSPNLKPDEAPRGLFSWLSHILGKPESFIIQQAGVDGYFFVRFLFGFASICFLGCCILWPILFPVNATHGKGRSGFDILSYSNVGNKWKVFAHVFLSWIYFGCVLFFMYREFVYYTTFRHVLQTTPYYGSLLSTRTLLLTEIPEILTEEAELRTYFPTATNIWYGRDMKELQKKVKERTKLAKKYEGALNKVVSKAVKLRLKLQKKNKPVPEPADDLNKYLKDGKKRPTHKLKFLIGEKVDTLNYGAEKLGELNKEIKKDQLESQSNTQLPSVFLEFPTQLELQKAYQAIPYNPDLKGTKRFSGIAPDDIIWENLDLTLWKRKLKKFIASTVLTLMIIFWAIPVAVVGAISNINNLTDKVHFLRFINNMPPKLMGIITGLLPVVALAVLMSLVPPFIKKMGKISGCITIQEVEGYCQAWFYAFQVVHVFLVTTVASAAASTVTSIVSNPKSAMDLLGQKIPPASNFYIAYFCLQGLGISSGLMAQVVALILAQFLGKILDSTPRAKWNRWNTLGQPGWSVIYPTYQLLGSIGIIYAIIAPLVLGFAFLTFVFIYAAYLYMLTYVMTPNIHDARGRNYPRALLQLFVGLYLAEICLIALFVFQKNWACVALESVAVAASAATHIYLKWKFLPLFDTVPISAIKYAKGDTTYQYPMYDQGTKEIKVEGENYWQGGNQLGLVDGDSSSDKPQTGAGAASTLPESDYSAKNEEENYGSFKKDLEAKPEENVLGKVNPAKGVSWLKRFFQPKTETFDLIRGIIPDAYFNYVTYNDDFIKHAYDDPSVQDDEPHIWVARDDLGLSEIEKNKALEHGVDVSDENTTFDAKGKISYTGPPPSYEEAIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Y1</accession>
    <name>G3B1Y1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_92794</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Y1"/>
    <dbReference type="STRING" id="590646.G3B1Y1"/>
    <dbReference type="GeneID" id="18250231"/>
    <dbReference type="KEGG" id="cten:18250231"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="628"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="810" mass="89523" checksum="1EEB2D8AB6EBF809" modified="2011-11-16" version="1">MAHNNHIEDQEPELFSVASHLSHVASNPGKHQYEIEEYQQGSSNVVVPEYHESEITVVDYGKSVFANPVQKFLHYLISLFPIAKWILHYNGRWLYGDLVAGITVGIVLVPQSMSYAILAGLPAQYGLYSSFVGVFIYSFFATSKDVSIGPVAVMSTQVGKVVAKVLAANGDRFTAPEIATFMSLICGGIAAGIGILRLGFILEFISVPAVMGFMTGSAFNILTGQVPALMGYGSSVNTRDSTYLVVINSLKNLPNTTVDAAFGLVGLFILYTWKWFTEFGQKRWPKYKLWFFYVQCLRNAIVLIVSTAICWGVVHPKLKAWSGPIAEFVPPVKILGTVPSGLRHVGVMKIPHGIMGEIGSEIPASTIILLLEHVAIAKSFGRVNDYKIIPDQELVAIGVNNLIGTFFAAYPATGSFSRSALKNKCGVRTPLAGIFTGAVVLLALYTLTDTFYYIPKATLSAVIIHAVSDLMAHYKTTWNFWKIAPIDAGIFLIAVIICVFSTIEIGIYFAISASAAVLLFRVAMPNGEFLGKVKVAEVINPIIDSKSYDNSKEYDGSGSSSADSFRDVEIHQVLSNNSDINKKKQVDQLDTSTKQLLAKNPNIKFHTRWVPLSTKNVNKNLDVQLPPDGVLVFKPIESFTYPNASRQIDKILDYVKKHTRRGRPYPKDKGSRPWNDPGPLEFKLPWSKKQNDVIEDVVDDRPVLRIVHFDFSTVASTDVTGIQTLVDLRKSLNIYTDREVEFHFSGILSPWIRRGLLNAGFGSYENNALVSNTTYVNIATDQDLEADLDSEYFSAVSTDTPFFHLDIPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2E4</accession>
    <name>G3B2E4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_133972</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2E4"/>
    <dbReference type="STRING" id="590646.G3B2E4"/>
    <dbReference type="eggNOG" id="ENOG502QRG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_0_1_1"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="11">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="373" mass="42229" checksum="00D6380B8DB793CE" modified="2011-11-16" version="1">MPLDEYTLCQLLGESANSTMHEHYDTFITETDIEDIKNYGLNLVRIPVGYWAFRKFEGDPFVSGSEAYLDRAIEWCEKHGLKVQIDLHAMPGSQNGFDNSGQRTTNPIWLETPETVELSTQVLDYVMQKYGQQFRGGQQHRNPQRAVCIHHRFHDVYNSAVAHNVTAQLYFSDGFLPISEWNDFMVNTTGYQPIMDHHIYEIFTEDQIKLSIDQHVANIVNIGEQMLAEPHNSVVGEFSGALTDCTKYLNGVGMGARYDGTIGGTDAVGSCEGHENYELWPQEARENTKRYLEVQMETYASNSSGWIFWCYKTESAIEWDFRRASSVGLIGNVSLQPKVEFGNIDSGIWITVSNGGTKSIDSFTPAMRLDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2L9</accession>
    <name>G3B2L9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_97565</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685519.1">
        <property type="nucleotide sequence ID" value="XM_006685456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2L9"/>
    <dbReference type="STRING" id="590646.G3B2L9"/>
    <dbReference type="GeneID" id="18250694"/>
    <dbReference type="KEGG" id="cten:18250694"/>
    <dbReference type="eggNOG" id="ENOG502SCWT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1610525_0_0_1"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018854">
        <property type="entry name" value="Psome_chaperone_3/4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10448">
        <property type="entry name" value="POC3_POC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16694" checksum="EE76D4A524AE9481" modified="2011-11-16" version="1">MSEPKFSTHLTKTYPDADNTEVTFHKIEAADTIILNVLTNGIADTTFELPLNSQHSINILSNLSNFEDDEEKMGIEPRVIVGDHNNLKIQVVASQIGKLLLSNMSEPKSVILSIGSRWFGKSTETNDEDFKKLMFVLTSVNELLAQSKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B386</accession>
    <name>G3B386_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_98094</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686421.1">
        <property type="nucleotide sequence ID" value="XM_006686358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B386"/>
    <dbReference type="STRING" id="590646.G3B386"/>
    <dbReference type="GeneID" id="18250744"/>
    <dbReference type="KEGG" id="cten:18250744"/>
    <dbReference type="eggNOG" id="KOG4778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126124_0_0_1"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3440:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="134" mass="15575" checksum="30B56C81DD3374F5" modified="2011-11-16" version="1">MISNTLKITVRTKATTTVNPSTQRVVNQLSALSASRKQPKLIKLSHEDLIKHNTIQNAWKSFTRKQETKRYQQLQQQYESIHNAMDTLKAISPSLYQMANKSDENNWYPLNMRVPTDYPANMPWVYNHKNQGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3A5</accession>
    <name>G3B3A5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_93631</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3A5"/>
    <dbReference type="eggNOG" id="ENOG502RGCG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031316_1_0_1"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442710" description="Agglutinin-like protein N-terminal domain-containing protein" evidence="13">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="14">
        <location>
            <begin position="52"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="300" mass="32029" checksum="6881A990AD276B88" modified="2011-11-16" version="1">MIRLFWVLLWFCASPIAATQVTGIFTSFNDLTFQSSGYDQIPSSPSWYATLGWTINGANVAAGDTFTLTLDCVLKFTDSASTFNLAVGSTTYATCTYSNGELIVPYSTINCVVSSSITTSTSASGTVSFPFTFNPGGGGSSVDLTDSTCFSAGTNTASFHDGSNTLTHTFTVISENTSSNAKSYQLVRSMPSMKRTQIYHLGATCNGGIVSGSFGMTVSGFDCNNMHVGITNNLNDFLMVKPTYSSFSMTGTCSTSGYVVTFSNIPAGYRMFMDTLVPFPSNGYLGVTLTNTVWKFGVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3B6</accession>
    <name>G3B3B6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_105138</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3B6"/>
    <dbReference type="STRING" id="590646.G3B3B6"/>
    <dbReference type="GeneID" id="18245784"/>
    <dbReference type="KEGG" id="cten:18245784"/>
    <dbReference type="eggNOG" id="KOG0211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015533_2_1_1"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000062">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="295"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="343"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="375"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="5">
        <location>
            <begin position="542"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="567"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="643" mass="72816" checksum="3F7A3ED4AA02A928" modified="2011-11-16" version="1">MENFNDDLYPLALLMDELKHDDVSNRVQAMQKVDTIAMALGPERTINELLPFLNDVAQDDEEEVFAVLATKLGDFIPLIGGHQNCEPLIQILLHLAPIEEPIVRDKAIASLNNISTELTNEEVFEIFLPIIRDLSQGNWFSKRIASCGLYKSVVVRVEAPVRQELLALFLKLVTDDGPMVRRSAATNLPAIINKLTDFTGIDANDPNKVTNKDWEIISQMFQSLINDDQDSVKFLSIDVLISILEYFQKIQDQSHNSDFLVNSLKLMSDESWRVRYTAADRFNRIAENFGNEEAKLTKLIEPFISLMKDNEGEVRKAIAKQLPAFCKSLNKYEALKPTILNKILPVVNELSQDPQENVRSSLALNITELSSILSKQSTIDKLLPIFLNMLKDEFPDVRLNIISNLSIVNETIGINLLTTSLLPAITELAQDSKWRVRLAIIEYIPKLADQLGEEFFNKELLTLCLSWLWDSVYAIREASVKNLRKITEIFGSAWADKYIIDKLVSIKNNTHSSTLNNNDNNDDTIHDDNDNDEINIDFASFIIRITCVFALNELIPVLDHQIITEKVLPFLNDLIDDKVPNIRFNLATSYLRISETLAGKQGDSPVIEQNVLKNLDILVNDNDSDVRYFASKSIDSIKELLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3N2</accession>
    <name>G3B3N2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114259</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Prevacuolar compartment membrane</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3N2"/>
    <dbReference type="STRING" id="590646.G3B3N2"/>
    <dbReference type="GeneID" id="18247342"/>
    <dbReference type="KEGG" id="cten:18247342"/>
    <dbReference type="eggNOG" id="KOG0997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025637_0_0_1"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="137"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="275"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="390" mass="45320" checksum="AE070E50D20C7893" modified="2011-11-16" version="1">MFLNRSPVVLVSVTKIKYEMILNQNTNQNSLLVNQLHSLYEYLVSILTKPVIMRLFHNRMNYDLRKSLTQLDFHNLDRLAMKLTYGLDEDDDLKHGLDYYLSALMDNSSKTACITNTTRQKLNSILLSSRTNDLPDYLFGLLTVGDQVVSVMKPKTHELGNKDVRNLMMIISNNQHSNMSEDLWIPICMPNFNSNGFLYCLVKTFDLSKYLLVDGKFHRPLPVNVVLLSTDKNNFFKMQEVAEGIIDQVVESDSYRNSLHDELVAREQLVTKPSMVHYVYKDKSKDQFVSSPLDLTDKFMLFKYVYYYTNLVNSKTTTIKSLTSDGVDKKLTYLKFDNYVGFMLSDQTYEFYCISTEGKLTTLINDVLGVVKWCKQRHKRLFNNNVRYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3T6</accession>
    <name>G3B3T6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113767</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3T6"/>
    <dbReference type="HOGENOM" id="CLU_3019797_0_0_1"/>
    <dbReference type="OrthoDB" id="3976101at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="56" mass="6225" checksum="4D2E095859D46727" modified="2011-11-16" version="1" fragment="single">MIFGNSSSPTFSNCEGYATSYNRPTTLSGNRRTGKTTHTQWAVLTTTQMVMASYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3V9</accession>
    <name>G3B3V9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_113784</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3V9"/>
    <dbReference type="STRING" id="590646.G3B3V9"/>
    <dbReference type="GeneID" id="18247122"/>
    <dbReference type="KEGG" id="cten:18247122"/>
    <dbReference type="eggNOG" id="KOG0646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029749_4_0_1"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="467" mass="51402" checksum="C26CAC4666A17BA7" modified="2011-11-16" version="1">MEEVIFYVGQGDPTDKQSQESYAFAQSVHGSRQLQMFRNADCAKNGAAFTGVGIGEKAFIASPNKALINVYSFGKDGIDQRMPVPEQVNCLAVLKMNTSPSDQSLNKPSYRTPWLLAAGSKTGKVYIWDILSGELIFAKDVHYQSITKIAFSKCGTFLITGSEDSRCLIFKTIELVSIFNKDHDTNVKPYMSITDHTLPVTDFYVSNGLINDVSLYTVSIDSTLRVYNITTRQLMHTFVLSSSIECVTVDPCGRNMYLGLTNGQIRVVPMFKVNNMNLERAGKFGEILTVPNDPELQNTLTAHDSAVSQLEVSLDGMSLISGDVNGNVYVSDITSKQIVRSFKISTAITHISAIVCPEEAIKNDLVADKRSRLLPPLKRVLQGLDQVSYEVNVEIPEAQTHSDISFQHWLDAQASDELSFKIGTTSSTGTTTTTSSEDGQKLAKLSTAYAELKAKYDELLADHRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3X8</accession>
    <name>G3B3X8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_104997</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3X8"/>
    <dbReference type="STRING" id="590646.G3B3X8"/>
    <dbReference type="GeneID" id="18245769"/>
    <dbReference type="KEGG" id="cten:18245769"/>
    <dbReference type="eggNOG" id="KOG2661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_1_0_1"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="145"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="340" mass="39508" checksum="398080ABF54C9D97" modified="2011-11-16" version="1">MKWIFGFRGVKSPVRSFLATRNCIRTFSQSPRSHATYKRFENSQSYDFSRLVSSKPLLYTVLGLGAFYVYNQDEAPFTNRRRFLWVPYWMEKRVGDMSYRQILLQYKKQIVPHSDPIYAKVSGIVNRLLEAAFENSRDPKQIEHLKSLKWEIHVIQVNPKETPPNAFILPNGKIFIFSSILPICHDTNGIATVLSHELSHQLAHHSMEQLSKQPVYMALSTLLYMATGVSGFNDLLIAGLLTMPASREMESEADRIGCELMARSCFDIYQIPRFWERMHAFEEQQSGQARTSMLNEFFSTHPNTNKRIHDIQSWMPQLESISESSNCHQYGQFNQLRSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B438</accession>
    <name>G3B438_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Low temperature requirement A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_105172</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B438"/>
    <dbReference type="STRING" id="590646.G3B438"/>
    <dbReference type="GeneID" id="18245787"/>
    <dbReference type="KEGG" id="cten:18245787"/>
    <dbReference type="eggNOG" id="ENOG502RZXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022899_0_0_1"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53446" checksum="53547864F1DE0926" modified="2011-11-16" version="1">MTDITPTSSKKLTSRLSQALESGAQEGPIVLTDSEDEDEFVKKYGDIDFQYIKRPRTSFWFTRPHALNYFQDGVLYRTKGERSSTKTELFLDLMYVGIIANLAGDATEHAGWGALLKYILLFVAVWTVWCDIKDFTNYYYNEDLSQKVYILWILALLTVFCNNQTQILANRSGAAFVVGPYILCRVSLALGLFVYTFWIPEHRVQQRVYSATIMVTSCLWIIVVFVGTRAKIGLAVAIMVLENVCFVTCFTPWFKRQLGLTTSTALNIEHEVERFSVFVTIAIGEFLYKIVAGGDLDLGFQVHLWRGLLLLVDAYVLFWIYSYGSMARRATHALRHSAFRAVSWIYLHLPLVASIVLAADAGGDLVSINETKEAEEAEEAVDITAVKFFFTGGLCVALVSMGLLGLTDDPKDPPETYIVGRFWRVVFRIPVGVIVLVLPFGDLGITGIMGVATILMVVLLVWESVSGTPKNCLFGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4A6</accession>
    <name>G3B4A6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_121804</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4A6"/>
    <dbReference type="STRING" id="590646.G3B4A6"/>
    <dbReference type="eggNOG" id="ENOG502QS5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386887_0_0_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="678" mass="77093" checksum="B97C30E0B5D05103" modified="2011-11-16" version="1">MRPYAKYNRSPIACVSCRASKIRCVRQQNLPSCKRCKELALKCESEIKISQQSGLINKKIASPTSTPQHISPILPTKEFVVELVEIFFANQYQGIFPFIHRPSFLEFLKSDEFNPSTYIDDYNSKFFTETYSTSLRYPDPVLLLSILALCARLHSGISFAYGKFSEDTAPESFEPYILTSDSEFSTYIKSDTDLVSASNASKYFGWHARRYMKDVFDSPTVQRIQAFTLLSSHEWGEGNNSRSFLYIGIAARMALVLGLGNENTICDEDVHDKNLGEIVTESKRRTIWSVYMMDRCNSSGRQRSPAIRIEDIKVKLPSNENDFLFGNPNTSLMYDELTKSMQGGASGHSRNISMIGFTIVVFEIWAKIAKWVGEVGVKYEKSSPWLSESVFHCLRQDLDSVAVLLPPDFQLSGFNLKMHMELGTATHFGYFHGLFFICRIFLNREYLFCNPDSFPPGWWKDLTVQLLDSLESISSLVEELRSKDMMVIAPFTGFEVFTCAVTSFYFCAFPDEILLEHLPVEKLGVVNTRSDLGDWKFKYKKLALKNMDCLTKWTQTWELGRKWQKLSVNLGIIFGQLAANGSDEFNSDYLRHSMQDYGSGEVAEVYVPQTSHKKHDKSDMEIMRLLNKDSTPASVSEENSQEMSSGDFGVIELLSPPQFMFSTNSLSIYPGWNGSDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4D7</accession>
    <name>G3B4D7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113840</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4D7"/>
    <dbReference type="STRING" id="590646.G3B4D7"/>
    <dbReference type="GeneID" id="18247141"/>
    <dbReference type="KEGG" id="cten:18247141"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="324" mass="37387" checksum="A9E4730A004F32F5" modified="2011-11-16" version="1">MADHQEADIDSIVDRLLEVRGSRPGKQVTLLEHEIRYLCTKAREIFIQQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNTMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPADKQSKYPPHPLMGNNPQRKQKRGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4E7</accession>
    <name>G3B4E7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_97846</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4E7"/>
    <dbReference type="STRING" id="590646.G3B4E7"/>
    <dbReference type="GeneID" id="18250718"/>
    <dbReference type="KEGG" id="cten:18250718"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_3_1"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="547" mass="59830" checksum="DDA1A33042EC718E" modified="2011-11-16" version="1">MSAVIGISFGNTSSSIAFANGEGKVEVIANPDGDRSIPSTLAYVGEDEYHGQQANAQLIRNSKNTIINFRDFIGKTFDEVNTEVTKTGAPAIKTADGSIGFNITRQDGKVEVITVAEATKRHLKQLQNAAEDFLGKKVEGAVITVPTDFTEAQREELIKLSNETGLKVHQLINEPSSALLSHLTQKDESYSQNKIYLVADFGGIRSDAAIIAVRGGILTVLSTLHDKELGGDRLDEALMEFFAKDFEKKYKVNPRTDARSLAKLRSESIVVKKTLSNVQSSTCSIESVAEGIDYHTTINRLRYELTIRGTISKMTGFVEKLVERAELIPSEINEILLVGGSSNTPKLSSELRSLFPESTAIISPVFDTKAILPNELICRGAALQAALIESFDDDEIKESLQPIVVNTQHLVHSIGIKDADGKFVPIVVSETAYPIKRSLEVTNGESSSVLVELYEGKKSIKETVIEPTKVEYSDDEEDSSEEDEEPEIIKEVVEECGELLGSLSLKDLKPASKLEIIINITQDGKLHISSRELKVGSVATKVELEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4P2</accession>
    <name>G3B4P2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_105299</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4P2"/>
    <dbReference type="STRING" id="590646.G3B4P2"/>
    <dbReference type="GeneID" id="18245796"/>
    <dbReference type="KEGG" id="cten:18245796"/>
    <dbReference type="eggNOG" id="KOG2050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013994_1_0_1"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="133"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="678" mass="77296" checksum="76A8562E1421D2D6" modified="2011-11-16" version="1">MAVKNRGIKRASEATSKQSKKAKIVQAESQSESEVSSQEESDASSESSSDELDQSEDELDQSEDQLDQSADELDQSEDGLDGSDDEDKENITDPNKKSSKEQHAEQRKMLAERKLKRKSGIQVQQIKSLWERLRVNKPTPAKEIRDKLSNEIWELSKDCIPDLVMKHDSSRVVQTLVKYSSKERRDLIVRSLRGSFYVLATSAYGKYLMIKLLHYGSKESRGLIVDELHGKLRKLMRHREGAYVVEDLFVLYSNAEQKQQMIREFWGAEYAVFKESGKGKSVLDIVNESTEKKQLILTNLSGTITASVEKGSTGFQILHAAMKEYVSILVSDLDQYDTQIREFEELLGEQFAELVHTREGSEVACWLIAIANAKERRNLMRSLKKHGKELIKNEYGNLVLITLFLTVDDTVSLHKNFDNELFTPELLPEVLQEKFSRRPLLYLLKGLDGKYFNPLVKKELLKYEELAYKKTSKKPQEQRRAELVEKALPQVYKNLLEVIKVDENAFVNQVLSANLGAQTLAELILTPSANEEINTTLRPKLIDVIFNSVIKGDVLEDYHLLNKIPFISRLIKLLTHGNEFKFDSEKKKLTQLKSETPLPGTGKEFSIRVLDEIVENGKLADWCTGQGSFIVLSVYEVLETSKETEKLKELKKHLKKIKKQLADDKGNKGAQIILKILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4R6</accession>
    <name>G3B4R6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113881</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4R6"/>
    <dbReference type="HOGENOM" id="CLU_2757549_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="70" mass="7894" checksum="845982FCF5542CFC" modified="2011-11-16" version="1">MYMCYFYNRSKPDLFLLRTYTSEDQAITYCNSDRFADNAARFSRRNAAALVTGGNKRGPRGAGTISWAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5G2</accession>
    <name>G3B5G2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_106468</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687008.1">
        <property type="nucleotide sequence ID" value="XM_006686945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5G2"/>
    <dbReference type="STRING" id="590646.G3B5G2"/>
    <dbReference type="GeneID" id="18245888"/>
    <dbReference type="KEGG" id="cten:18245888"/>
    <dbReference type="eggNOG" id="KOG2103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320547_0_0_1"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442535" description="ER membrane protein complex subunit 1" evidence="11">
        <location>
            <begin position="21"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="780"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="602"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="813" mass="92388" checksum="156286C62486F492" modified="2011-11-16" version="1">MVRLTQFLGFVVLIATCVSGVFLEDAFTKNWVKYNHALIKSFDAIQDSSFVGVTLDGELVKYNLTNEAVLSWKVTVPLNDVEYLINGGTILTYSTSEDTIYLWDIQSGVLLNNYQVGPVKYISRSFGGFIVLSSNSLLTFVDGNLSKEIATSVGDIWASEFNGLTYIVTDDSKLLKLDPNFKYTTVDINVKFSKISQIVGNRVLVNGQVFDLDKNQITTKAKVTGLFESEPAYSLEKNKFKIIKDDKVVLEDDFEESSVKVLQNYLLVDSEDERKVIDLKGFFESLDETSINLESYNHSITGKDYIFGNEIVSLIVTGKFIQFSRYNILLDKVAHYNYHINTYNLNFPKALLINKPESKQTMDSIQHLVDEIQQNNVLSRFIKRTRRHLVEFGKSIISKVTRLDFNSDHIEITNPYDLEKLLVFVDDSKLVAVDSLNGDGVWETVIEDGLLDLEENGDTMSLVYGDKAITVSTRDGEIIDSHDRTSSVDLPQGTIYVKQVENSIQSYKYVDGKLIPTWKFAKDKIINFAIKPNTKTGSVGIALHDKSVLYKYLNDNSIAVIAEEDGILKLYLIDGKSGNVIYVQEHLKSDNIDTKSIKLILDDNWIIYSYFVTEPKYEQRISVVDLFGEAPTKGNFTVPISSSSSKSFIYPERIIDLKSTYTRFGITLKSIIALTEDGDLVELPKYILNSRRIDDRQLSQNDFKDDFRMLPYEPVVARNDYSVLNHGYKLDTGSNNLILLKDTKLESTSIICMINSRNMFCTRVQPSLSFDNLTEAFQKFRLIITIFVLFVAYFVTKPMVIKKNLNSQWIYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5L4</accession>
    <name>G3B5L4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114552</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5L4"/>
    <dbReference type="HOGENOM" id="CLU_2284036_0_0_1"/>
    <dbReference type="OrthoDB" id="4022940at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="102" mass="11142" checksum="7636FF4D50D42480" modified="2011-11-16" version="1" fragment="single">MAEEPLSAQGQRPHSASTSQISSVGFTNLKKLNTNSSVSTASSTVSISKQNPLTRLFTRNKSNVTIDEPSQSDDDDNRSMRTIPISPIERKASSNVFRLSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5L5</accession>
    <name>G3B5L5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Chitin synthase</fullName>
            <ecNumber evidence="2 7">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_106977</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 7"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5L5"/>
    <dbReference type="STRING" id="590646.G3B5L5"/>
    <dbReference type="GeneID" id="18245927"/>
    <dbReference type="KEGG" id="cten:18245927"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_1_2_1"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="775"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="916"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="943"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="9">
        <location>
            <begin position="241"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="998" mass="113940" checksum="76E93EC3C4BD1A1D" modified="2011-11-16" version="1">MPSPFEDNPFSDKPSYPDPAFVDRNSPRRYKPQNDDDDDFVAFPESTRRSPDIFTRSGRINANINKVALNNTPNLQFEGRTARAQFTSRESPKRQKAMGIAMDDTLDHDDDDAESINLTGSPHRGSQYGRSVNSSHRSERFLEPPQPIFSPETYAEANPYEDDEDDQETIGRDSYDYDSYQKAQEFEERSLYSESTAYHSSASNDGYTNGSESEYFAASIDNDMMNNIKSGFVPNREKTITKRKVRLVDGQAGHLVLENPVPEELRKVLTRTESPFGEFTNMTYSACTSEPDDFIKDGFSLRAAKYNRETELVICVTMYNEDEYAFARTMHAIMKNIAHLCSRNKSAMWGKDSWKKIQVVIVADGRNKVNESVLQLLTATGVYQGNLARPYVNNKKVNAHIFEYTTQISIDENLKFKGDEKSLAPVQVLFCLKEKNQKKINSHRWLFNAFCPLLDPNVVVLLDVGTKPDNHAIYNLWKAFDRDSNVAGAAGEIKAMKGKGWINLTNPLVASQNFEYKMSNILDKPLESLFGYISVLPGALSAYRYIALTNHDDGSGPLDAYFKGEDLLNTSKAHSNTKTNFFEANMYLAEDRILCWELVAKRNENWVLKFVKSATAETDVPETISEFLSQRRRWINGAFFAALYALKNSKKIWQTDHSIARKFWFHVEFIYQFITLVFSFFSLSNFYLTFYFLTGSLIDEVGHNGGFWIFTIFNYLCIGVLTSLFIVSIGNRPQGSRGIFKTLIILLTVCALYALVVGIYFVANTIKEYGIGDSSTYVMISIIVSLLSTYGLYTLMSVLYLDPWHMLTCSIQYFLMIPSYTCTLQIFAFCNTHDVSWGTKGDNNPKEDLSNQYIIEKNEEGEFEAVVLNVNIDEVYLETLYNIRAKRSSKKVLGAHQPDDIMDGEDYAKDVRTRVVLIWMLSNLVFIMTMLQVFKAGETKQNYYLGFILWSVAFLALIRAIGSFGYLIQNYARFFVETKSKWLHKRQGYNLPNAHKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5N3</accession>
    <name>G3B5N3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_114565</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5N3"/>
    <dbReference type="STRING" id="590646.G3B5N3"/>
    <dbReference type="GeneID" id="18247479"/>
    <dbReference type="KEGG" id="cten:18247479"/>
    <dbReference type="eggNOG" id="ENOG502QPST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005131608" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="13">
        <location>
            <begin position="380"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="536" mass="58362" checksum="D67C56D8D68C6B0B" modified="2011-11-16" version="1">MLRNFSFVLLCLLLSLLNLTTADELSEIEVVGNKFFFKDNGTQFLIRGIAYQENTANSTADGGSTSINDPLADPDSCKRDVKYFQESNTNALRVYAVNTSLNHDECMKTFADAGIYIIADLSEPDKSINRESPEWNLDLYERYTNVVDMFANYTNVLGFFAGNEVSNNKSNTDASAFVKAAVRDTKKYMSDKKYRSIPVGYSSNDDEDIRVAIADYFACGDSDESADFFGINMYEWCGDSSFKSSGYEARTEEYKNLSIPIFFSEYGCNAERPRKFTEIGTIYGDDMTDVWSGGIVYMYFQEDNDYGLVSVDGDTVKTLSDFKYYSSEMNNISPSLAQSSEVSDSASTIACPTSAATWSASTKLPPTPDSEVCKCMASSLSCVLADDVDTSDYSDLYGYICDKIDCSDISSDGKKGKYGDYSFCSDEDKLSYVLNAYYKDQNEDKSACDFSGSASINKDAKTDATCASSEASESGESSSGSTSGSGSGASGTADSDSSNSKGSSATIVESWSISQLIGITTIITSFIGGISFVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Q7</accession>
    <name>G3B5Q7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ran-binding-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_105890</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Q7"/>
    <dbReference type="GeneID" id="18245849"/>
    <dbReference type="KEGG" id="cten:18245849"/>
    <dbReference type="eggNOG" id="ENOG502R7I3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014536_0_0_1"/>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44218" checksum="D61883A4822A784C" modified="2011-11-16" version="1">MDDFITKASSQAVSFAIRSGISLASGYAIRTVTKFVDKIPEKDKAQLNNKIHRVKLQINIVSPSIELIKSMNAGGFSSLQSCNELIDQMTQSFREFDDMVEKWSDQLSNSNTGDVIKQVNKQLDGLIDMIDQTVPLLNLCIVTSGINLNRDLSEEISINKLIEASNIILGSRDSTNTGPVFDLTFFSVFYNPSRLKYIEHESGNQEDETPITWKEEFARAKVSIKSTGNFSYDLNIIEDFDDDRYHEGAPKTKVVKVNDVRKIFFSRSGKLLRLDNNDSAVLILKLDDEYIAFGIYEDVDSESDNNESDDSEDEIEKGETAKQETSKSLSLLEYILRLTILEQVESKSLIEITDEKLLIYLNNEIPRKSSKVSTQTLDMDSNVNRLENLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5R2</accession>
    <name>G3B5R2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Synaptobrevin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_98432</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5R2"/>
    <dbReference type="STRING" id="590646.G3B5R2"/>
    <dbReference type="GeneID" id="18250772"/>
    <dbReference type="KEGG" id="cten:18250772"/>
    <dbReference type="eggNOG" id="KOG0860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_2_1_1"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000063">
        <property type="entry name" value="Synaptobrevin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="111" mass="12450" checksum="86FE28DAA891EEC1" modified="2011-11-16" version="1">MSSSVPYDPYIPSQTTGDQSNSRTAAIQAQIDDTVGIMRDNINKVAERGERLDSIENKTDNLAISAQGFRRGANRVRKDMWWKDMKMRMCLILGVIIVLVVIIVPIAVHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Y7</accession>
    <name>G3B5Y7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_107114</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687126.1">
        <property type="nucleotide sequence ID" value="XM_006687063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Y7"/>
    <dbReference type="GeneID" id="18245935"/>
    <dbReference type="KEGG" id="cten:18245935"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54764" checksum="C52F490A4C0B2101" modified="2011-11-16" version="1">MPSILHKAKVLLWGETPKDPKEARLLLKMDWFILSFACLLYWVNYLDRLNLSNAYVSGMKEEIGLVGNQFNVINTMFTVGYVVGLIPHNLILLRVRPSIWLSVCGFCWGVLVLGMYKVEHFYQLCVIRFFQAFFESSTFTGVHLILSQWYKEEELTKRTAVFTSSGLIGNIFSSTMQASIHTTLNGRNGLSGWRWLFIIDFIITVPIVTYGFFFFPDTPATAKAIYFTEEELEIARRRMPPAKTDVFNWSIVRRVVGSWKWYLFSLLFVFAGENESYSTNSLFSLYLTYFGYSVDARNHYPMGMYAMGVFFTFGFALYVDGTGARYHWHVAVATAVIMIISTIMMLAAPDKSSVMFAAHYLSGCSYAGQASYFAWANVVCANDLQERAVVLASMNMFSNAVNAWWSILFYSADTAPHFTKGCYAMIATVVASVVVAGLIRVFQLRDERIERSPADDEKSEHSIGKDGVVTQAQEVESGSVEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B637</accession>
    <name>G3B637_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_106029</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B637"/>
    <dbReference type="STRING" id="590646.G3B637"/>
    <dbReference type="GeneID" id="18245858"/>
    <dbReference type="KEGG" id="cten:18245858"/>
    <dbReference type="eggNOG" id="KOG1750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_0_1_1"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18780" checksum="1A3D6E1A01B993D5" modified="2011-11-16" version="1">MFRSLISGIKVVKPALSSTNYVSSIKQNVGIQTSLIPQAFNYQKRYATLNQIKSGKQGIPNKPYIPGAPHLQGNPFKKGVVLRVMIVKPKKPNSAQRKCCRVRLTNGNVITALIPGEGHNLQEHHVVLVRGGKVQDLPGVNYKLVRGAYDLNGVANRATSRSKYGVKKPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B639</accession>
    <name>G3B639_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114685</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B639"/>
    <dbReference type="STRING" id="590646.G3B639"/>
    <dbReference type="GeneID" id="18247534"/>
    <dbReference type="KEGG" id="cten:18247534"/>
    <dbReference type="eggNOG" id="ENOG502S83P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152072_2_0_1"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="78" mass="8583" checksum="D61D780ED56759EC" modified="2011-11-16" version="1">MVSYIRGPAYKSIASFAGVSIPTAKKYLPNLVLWGGAAGAAVATFTEGVPLFQNTFYKKIPYFGQHWEYNPDPEDIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3B649</accession>
    <name>G3B649_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Chromatin remodelling complex ATPase chain ISW1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_106017</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687173.1">
        <property type="nucleotide sequence ID" value="XM_006687110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B649"/>
    <dbReference type="STRING" id="590646.G3B649"/>
    <dbReference type="GeneID" id="18245856"/>
    <dbReference type="KEGG" id="cten:18245856"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000002">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="151"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="448"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="15">
        <location>
            <begin position="819"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1002"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV63380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1018" mass="118337" checksum="FEBC4B4F6D863003" modified="2011-11-16" version="1">MTGKVIDRDEVDVPSPSPQPVVSIPQDTSTSTNVGQNRQKYFVTSDKPRLDAEDTAKRFKYLLGLTDLFKHFINAKAEKDAGIRKILNKVESERTGEQVPNHRGRKTEKEEDAELLNDEIETPAITEFTESPAYVHGTLRPYQIQGLNWLVSLYENNLSGILADEMGLGKTLQTISFLGYLRYFKGINGPHIIITPKSTLDNWAREFARWTPDVRVLVLQGDKDQRNQLINQRLMTCDFDVVISSYEIVIREKSALKRFKWEYIIIDEAHRIKNEESLLSQIIRMFHSNNRLLITGTPLQNNLHELWALLNFILPDVFGDSEAFDSWFQDNEGQDENSVVQQLHKVLKPFLLRRIKSEVEKSLLPKEELNVYVKMTDMQKKWYQKILEKDIDAVNGASGKKESKTRLLNIVMQLRKCCNHPYLFEGAEPGPPYTTDEHLVFNAQKMIILDKLLKKFKQEGSRVLIFSQMSRMLDILEDYLLFREYEYCRIDGQTDHADRVNSIDDYNKPGSSKFAFLLTTRAGGLGINLTTADIVILFDSDWNPQADLQAMDRAHRIGQTKQVKVFRFITEHAIEEKVIERAAQKLRLDQLVIQQGRHAPNISNQSNKAASKDELLNMIQHGAAEMFKSDSTSKAGTVEPEDDDIDAILAKSEAKTSELNQKYEKLNINALQNFTNDESVYEWNGENFKKKEPTAITNIGHAWINPGKRERKENYSIDMYYKDVLNTGGSRSTIKSGPKPPKQHNIYDHQFFPAKLLELLELEKNYYKKQIKYQVPLKSGPPNTLDERQLEQKLEQEEIEKSRPLTEEEKQLKDELLTQGFGNWNRRDFQHFITLNIKYGRNSIQLITNEFEDKTIDEVRDYAKSFWKKYEEIDGYERYINQIETGEEKIIKIKLQKEALRRKLSQFKYPLQELTLKFPPASSNRKVWSEDEDRFLLVQLYRFGIDRPDIYERIKEAIRDSILFKFDFFFQSRNTTEISRRCQTLLGCVLREMNPPVTGSKRKSETPDVGEKTKKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B685</accession>
    <name>G3B685_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_106551</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B685"/>
    <dbReference type="eggNOG" id="KOG2676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043683_0_0_1"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="7">
        <location>
            <begin position="304"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="408" mass="47288" checksum="3D3CFEDD42777D35" modified="2011-11-16" version="1">MVTQSISEPEIRVVLRSKTAKLQNLIIPASDDIQYLRLFRGVLLIIRNLVIETNDFEIETIATSLEQFQRVVPSSNEMYTKTVIVYYQIFANISQTKQPQCIHTLTKIMKFNDNTEHPVLVTLSNLFKNDQNIYDMLYNDYGIETMRHLTNFEVTEHPNEIERLYLEIWEKVVAHESFSKWIVKHDDEKVLKICQIVITSKDNWNNSQLLGILSWLFEMFKFLNGVAVASLNNKDLDSLGAVHPKLLMVLDCVSELSKFNIAKDFLINYEMVNLLIPLLRVVHESIEPKNMMKNKNQIIEFPHIKSIIIEILSYLTFENFKIQELIRELHGIEVILSSCVIDDSNPFMKERAIICLKYLLYKNAQNQEFVASLEAKKSVDSSLLEEAGYQVSINNSGKFELINGSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6U1</accession>
    <name>G3B6U1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_122693</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6U1"/>
    <dbReference type="STRING" id="590646.G3B6U1"/>
    <dbReference type="GeneID" id="18248920"/>
    <dbReference type="KEGG" id="cten:18248920"/>
    <dbReference type="eggNOG" id="KOG0794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034754_2_1_1"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="356" mass="41170" checksum="4794DAD8888F1842" modified="2011-11-16" version="1">MSADFWSSSQRGKWQFNRQSLLDQRRRLLILEKKMIQNGFIKDYPNITYDSNMRIYLHNLLIRLGRRLNVRQVPLATAEVYLSRFLLKVSLKEINVYLMVTACIYVASKVEECPQHIRLIISEARNLWPEYIPHEVSKLAEFEFYLLEEMDLFLILHHPYRSLIQLQRFLTANLDQYHFLLTNDELQHTWSLINDSYITDLPLLFPPHIIAVSCVYITIVLKKALNSIRLNKSITGDGMGAGSTGGGSTGDDHPESAQMDAHGTDKEMHIDDLMALTSENSASDNNALESGSGLQDMKLDEDTIRINRFMNFLGHSHINLDEVSEAMQDIINVYVIWNRYNEANVKKSLQYMLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B748</accession>
    <name>G3B748_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114408</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B748"/>
    <dbReference type="STRING" id="590646.G3B748"/>
    <dbReference type="GeneID" id="18247414"/>
    <dbReference type="KEGG" id="cten:18247414"/>
    <dbReference type="eggNOG" id="ENOG502S752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_4_0_1"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000011">
        <property type="entry name" value="37S ribosomal protein S18, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="212" mass="24120" checksum="F2F44A6405A50CA8" modified="2011-11-16" version="1">MIRPGMGVFSQIASAMTTRRILTPHRSLSNTAKFLVSQTPKNLASPINLDFNGAFKSKKNVSNKIVLWKLYGLFNKHNTHLTMVAVEEDPNFLEKNPDLSYTEQVLYYMQLPHHPKIHVSAGQLGFKKTQRSEYEAAYQVSSRMFKLIEERKLLSPNDRVELVLRNFGKGREAFLAALQGKEGSSVKDHIVRVSDSTKLKFGGTRSKKLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7D0</accession>
    <name>G3B7D0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone-6 3-O-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexaprenyldihydroxybenzoate methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <shortName evidence="5">DHHB methyltransferase</shortName>
            <shortName evidence="5">DHHB-MT</shortName>
            <shortName evidence="5">DHHB-MTase</shortName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">CANTEDRAFT_131623</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7D0"/>
    <dbReference type="STRING" id="590646.G3B7D0"/>
    <dbReference type="GeneID" id="18249542"/>
    <dbReference type="KEGG" id="cten:18249542"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042432_3_0_1"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="294" mass="33469" checksum="9D47407ABA779455" modified="2011-11-16" version="1">MAAFDSISKNKIASGSSAEELKHFNALASSWWDVNGPQRILHKLNLIRMDFIQETIRDHLKLNEGITNSDDEVYIPPYNIDLLPEGVRDTIVREQCARREEILALKKMKVLDIGCGGGILSESMARLSFVESVKGIDLSDEVIVAANLHKAKDPMLKHKLQYKLQSIEEIPKKEKFDVVTLFELLEHVDYPSKVLTEAMSKLKPNGWLFLSTINRDFVSWFTTILMGEHILGIVPVGTHTLSKYINHVEIKNWIASNSEYELVASRGSIYIPSYGWKFTNNENVGNYFMAIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7E7</accession>
    <name>G3B7E7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_107645</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Heat shock protein that may play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds human histatin-5, an antifungal peptide from saliva.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7E7"/>
    <dbReference type="STRING" id="590646.G3B7E7"/>
    <dbReference type="GeneID" id="18245971"/>
    <dbReference type="KEGG" id="cten:18245971"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_1_1"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="610"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="69753" checksum="FEFA3F8F5185F236" modified="2011-11-16" version="1">MSKAIGIDLGTTYSCVAHFTNDRVEIIANDQGNRTTPSYVAFTDTERLIGDAAQNQAAMNPSNTVFDAKRMIGRKFDEEQLQADIKHFPFKVVNKGGKPAIQVEFKGETKTFSPEEISSMVLTKMKETAEGYLGDKVTDAVVTVPAYFNDSERQATKDAGLIAGLNVLRIINEPTAAAIAYGLDKKSSTVGEQNVLIFDLGGGTFDVSLLAIDEGIFEVKATAGDTHLGGEDFDNRLVSHFINEFKRKNKKDLSGNQRALRRLRTACERAKRTLSSSAQTSIEIDSLYEGIDFYTSITRARFEELCADLFRSTIDPVERVLKDAKLDKSQVNEIVLVGGSTRIPKVQKLVSDYFNGKEPNKSINPDEAVAYGAAVQAAILTGDTSSKTQDLLLLDVTPLSLGIETAGGIMTKLIPRNSTIPTKKSETFSTYADNQPGVLIQVFEGERTKTKDNNLLGKFELSGIPPAPRGVPQIEVTFDVDANGILNVSAVEKGTGKQQKITITNDKGRLSKDDIERMVSEAEKFKEEDEKEAARISAKNGLESYSYQLKNSISEGELKDKIPEADREKLSSAVDETINWLDNAQQATTEEYSEKQKELEAIANPIMSAAYQSGGAPGGMPGGAPGGPAPGAGGSDGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7H9</accession>
    <name>G3B7H9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_109461</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7H9"/>
    <dbReference type="STRING" id="590646.G3B7H9"/>
    <dbReference type="eggNOG" id="KOG2006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288047_0_0_1"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="3">
        <location>
            <begin position="787"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="964" mass="112477" checksum="F90A33D2E16EB06B" modified="2011-11-16" version="1">MVWIDSLELSSPLATSEEVLEIIDMRYTSFIAILTPKSIIIVHESTLLPLAIHTRTQESIEQHGSNKRVKTKNLNLGVKMSRLNIFNLFLVTSQDYLLIYQVHIDPTKSVFEVSDNDNITLQKLLPVNSNSERFSFTKMLNSVTRSLGSNHINLQNLESFNIPVDELANFSIEYVRLSVFKTIKIGIGISKFWLKSNSHNLFVYRDNLIQVINIKTLNNEICNFIEFSWFDSQTKDIWYNYSFNYFIIADISNELWFMNVGENELNPEGHKLGLNLEINDLKFNPVYEVVLIKYRTRDGDTRLGLFRLDGCLRKATDIQISDWTDFRFQWSNDGEFFIVLDNKGRWFISSKFGNITTDTEILSNEINENYLSATQLLISSNDNSVLLIKDDQIHKVNLVRLLSQQDLIITSPHYFSLVESNKLRNKLLKYPLLSHFKYSGLASSSKAKLKVSKNYVNQFIISCGDKLSVSNRYKNAEGDYNHLIWFNFKNYFVETLNITNHVSFKQFLILINRATKDYGGKDKLVDELVIINLKDSGFAQGGSPFPFDSDLFIWRHALETILTFELVDNKLIILDSQYKLFIFELFDGYTNASGNYYDFYMKQSKTIDFTNMKDKLALSKITKIQMIDNLNFLILLNNGEFYILKNQSNKILLTSYFQLIQVQSCIEEFRINDITINEEMIKYIYLFKGNQLLIYNLTHLIDLIFEPVDLNPHDGLDEEEVTSQMKLIKPITIELENFQPLKIHKTLDSINLIGLQDLILNDSFIRVKLNTKLILNNLVEFDLLNATEVRMIHTKFSSFSQYTYCLELLLFDYLTKENPLIHSLLDLIKLADNYESIFINCLRKIEFKYWSNFFRILKTDPFNLMNKLLDSNNVQLGYNFLIIYLNLKSEEETENSSGYLDSNDEKIILSLIERLVNMCYWDWCFELCRFIKLLDPSSRLLIRIRDTVGNKSSHAAQLESSRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7K3</accession>
    <name>G3B7K3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_109033</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7K3"/>
    <dbReference type="STRING" id="590646.G3B7K3"/>
    <dbReference type="GeneID" id="18246080"/>
    <dbReference type="KEGG" id="cten:18246080"/>
    <dbReference type="eggNOG" id="KOG0209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="14">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="258"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV61635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1225" mass="136119" checksum="02198BADFCAC7CDA" modified="2011-11-16" version="1">MSQTNFVDNAAVVGTELLVPKAFLARPYVWPFAIIYPIFLQVYFFQYDVYIKGQEWTFVYLMALGSFNMLFWLMPFWNIDINTKFNYSKVNTIDEAKYIKVDPAPNSGTGEICLISREKFPDGETQISFAYQKRRHLLHSETGKFSPPQYLVDQLPKLSVFQSSTGLKGDLEKLARNYGANRFDIPLPTFLELFQEHAVAPFFVFQVFCVALWCMDEQWYYSLFSLFMLVSFEMTTVFQRRTTMAEFQSMGIKPYPIYVHRDGKWVKLQTDGLLPGDLVSLTRTSEDSALPCDLLLVDGSAIVNEAMLSGESTPLLKESIKLRPGEQSIEPEGFDKNSLLHGGTMALQVTQPEDPIVPLAPDNGSLAYVIKTGFETSQGSLVRTMVYSSERVDVGNKESFFFILFLLVFAVAASWYVWVEGTRMGRIQSKLILDCIIVITSVVPPELPMELTMAVNSSLSALQKFYIYCTEPFRIPLAGRIDVCCFDKTGTLTAEDLVFEGLAGFNPDDIHHLYSAEEAPETTSWVLGSAHALVKLDDGEVVGDSMEQATLKAAKWSVGDKDSVERSRGNGKMEKIKILRRFQFSSALKRSSSISSINTLQGKNLVSVKGAPETLRNMIVDLPATYEETYKSFTRAGSRVLALGYKYLPPTVNATKIAREDIESKLIFAGFIVFHCPLKDDAIETIKMLNESSHRCIMITGDNPLTACHVAKEVRITTKDTLILDAPEEHHEVGGHNLVWRNVDETVVIPVKAADKIDTSLFKKYDICLTGYALNYLVSHEQILDLLKHTWVFARVSPAQKEYLLNTLKDAGYKTLMCGDGTNDVGALKQAHIGVALLNGTEDGLKKIAENRKIGATVKVYEKQIALFQNWGKPPPPAPLIIAHLYPPGPSNPKYLEAMKKKGVEITSQMEKTVEYAMKTGKTITVDKSKAAQAGAGGIGDAFLTALNDAEEEDEAPTLKLGDASVAAPFTSKLANVSAVIHIIRQGRCALVATIQMYKILALNCLISAYSLSVLYLAGIKFGDAQATISGILLSVCFLSISRGKPLEKLSKERPQDGIFNKYIMGSILGQFAIHIITLVYITREIYILEPREPQVDLEKEFSPSLLNTGMFLLQLAQQVSTFAVNYQGEPFKENISSNKGMYYGLLGVAGLALSGSTEFMPELNEAMQFVKMDVEFKTKLTGSILLDLGATYGIEILLKFLYMNSAPADIAIRDEEEEKSDISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7U3</accession>
    <name>G3B7U3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115783</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7U3"/>
    <dbReference type="STRING" id="590646.G3B7U3"/>
    <dbReference type="GeneID" id="18248014"/>
    <dbReference type="KEGG" id="cten:18248014"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771587_0_0_1"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="359" mass="38924" checksum="67227A323D676AC8" modified="2011-11-16" version="1">MLHLAFEYGNFECISTFVEFLYNLSPNKAANLKLIKTFENSKNNNGWLPIELSVNFKLTRYYASFKDKLTSSSSNSNSDLDESISRGSYGTSSFKDSSSMLAEIPFVLGSDTRSNLRLEPDSSFSIDSSKSTTNGSPSPNKILASPIISVNEFNKRSHSQSLPTQSEEDIYSALRQRANTTLTPVALPLIPPTPSVIKKIPSLKSITISPSMRLDTEVDPIGIESSSSSTTTTSNSSPIKTTFPSIKTTSVKTDVKSSRTRSDSSAANEDTALVNSPSSIAAKIAFNSSKSSAASSRKNSNPEPSPVRLQNSNSNSQMRRDSSSSPLSHQNLQSPGSKQHLSPSKHKNSINSISFSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Y7</accession>
    <name>G3B7Y7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class II aaRS and biotin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_124686</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Y7"/>
    <dbReference type="STRING" id="590646.G3B7Y7"/>
    <dbReference type="GeneID" id="18249045"/>
    <dbReference type="KEGG" id="cten:18249045"/>
    <dbReference type="eggNOG" id="KOG2324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_2_2_1"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class II (G/ P/ S/T)" evidence="1">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon-binding" evidence="2">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="373" mass="42322" checksum="C38DA362350E70A7" modified="2011-11-16" version="1">MGLLRSREFLMKDAYSFDVNEHEAMKSYHKMVGVYHDIFSDLRIPYVKAVADSGDIGGSLSHEWHYLHASGEDTVFTCSHSECGNVSNIEKTLSVPETIVECETESRFLQVGEVEYIKVVYPKDRHFDINLLKHKYPKIQEIRHTPESYTVVEDSRVSPHGLPMVLSEEGEVCFECKSGKLFKKRAIEVGHTFYLGTKYSNPLGLTAKVPEGDKLVERDVVMGCYGIGLSRIIASIAEITRDSQGFVWPRIISPWNVTVVESNTLSEDPSEIYDSLNKAQVDYRQDNRTNVNMGRKISHSNMIGIPLSIILGKKFPLIEIEIRGKRYGEDLAWKQLYHTKSFEWHVSTHGGVEKHLVDKDGLIAVLQALLIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B836</accession>
    <name>G3B836_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_126135</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B836"/>
    <dbReference type="STRING" id="590646.G3B836"/>
    <dbReference type="GeneID" id="18249150"/>
    <dbReference type="KEGG" id="cten:18249150"/>
    <dbReference type="eggNOG" id="KOG2613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="315"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="516" mass="59093" checksum="CFFF077BDAD5F070" modified="2011-11-16" version="1">MSNYTQLDTTTQGVATVLCCNCGVPMDGSTGMVMCYDCIKLTVDITEGIPREANISFCRNCERFLQPPGQWIRAELESRELLALCLRRLKGLNKVRLVDASFIWTEPHSRRIRIKITVQGEAMNNTIVQQSFEVVYVVVAMQCADCAKTYTPNTWRATVQIRQKVPHKRTFLYLEQLILRHNAHQDTVSIQESSDGLDFFYSQKNHAVKMLDFLTAVVPLKYKKSEELVSQDIQSGSSTYKFAYSVEIVPICRDDLVVLPKKLAHHSGNISRVVLCSKISNMIQFLDPFTLQMTDLQPSIYWRNPFSSLISVTNMVEFIVLDVEPTGETRGKHVLADITVSRESDLGVNDQSYYIRSHLGAILHPGDSCLGYFLTNSNFNSDLWDSLDESNTPEVVLVKKFYPRKSKKSKNRNWKLKRMAREHQDIGGAEDSRQAKQEQERAERDYELFLQELEEDEEMRQAINLYKSTNPPVRDVEEESEMLDEEDAPQINIDELLDELDDMNLDDDDNEASPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8B4</accession>
    <name>G3B8B4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_124781</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8B4"/>
    <dbReference type="GeneID" id="18249053"/>
    <dbReference type="KEGG" id="cten:18249053"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF72">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="17"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="524" mass="58847" checksum="113398486521EA7E" modified="2011-11-16" version="1">MKYFEIWKPGKQVSIAVAFTCELSFILFGIEQGIAGIIITGEDFLNQFGNPTGSWLGFIVSIYTLGCFFGCIVNFFTGDMLGRRKTIAVAMCLIMVGVTLQCTSFSVAQLMVGRFITGLGTGMETSSVPMYQAELAKPHLRGRLVCSEALFVGIGLVFAYFLDFGFSYIKTPVAWRVPLSIQIPFAFIVLLMTFTVPESPRYLYFKGKKEEAKRILSYVFDKPEDHPDIVKNYQEIEEAISLETQDSDSSWKAIFVADHARTRYRIFLAYMSMFAQQLGGVNIINYYITTILIESVGLEHTLAMILGGVAVICFTVGSIIPSFFADKLGRRMPLVYGYAGCFICFLMVTILLNFQSNADLKASTGAAAVAFFFLYQLCFGASGNCIPWVYVPELIPLKYRAKGTAIGISSNWLWNFFLVEISPELISAGTRSHKQGLSYLPFVFTNFIFIFQFYFFYPETKNLTLEKIDELFSENRTIFMGLVDQRRFREGILSTAQSDIEKGTTPQSDIEKGTSEHIEIESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8D3</accession>
    <name>G3B8D3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_99379</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8D3"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF36">
        <property type="entry name" value="PROLINE-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="135"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="263"/>
        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="51"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="555" mass="60947" checksum="BA69B1AF1F857105" modified="2011-11-16" version="1">MKEAFPSSRLTLVPASTEVARRIWISPSPTLESSMEMIPDTTLHRGLKSRHVQLLALGGCIGTGLFIGSGGALSVAGPASLFLSYCIMLVVIFFVMNMLGEMITFLPLPGNGAQSFVKDYVDDSLGFAISWNYRYAFSILVPTEITAAALLIDYWPNSVHTAVWITIFLVVMVGLNLTSVKVFGEAEFYFASIKIFAVVGLIVLGVVLFFGGGPSHDRLGFRYWKHGLAFKPYLVEGPTGRFLGFWYAVIRSGFAFICSPELVATAGSEAIKPRANIPKAASRFIYRLGFFYVLGTLVIGIICDSRSHQLLNGSSDASASPFVIGIKNAGIPVLDSIINAAILTSAASSGNSFLYSSSRVLYSNAVKGIAPSIFMRVNRFGVPYFAVVTTSLFGCLAYLNASSTSANVFTWLSNIATISGFLSWTALSVAYIRWRKAISHNDLWHRVTYKTILQPYGAYFVIFFVGLICLTNGFAVFFNFNGPDFVAAYVTFPILAALYVSHKVYEYFKLGRVRFVRPIEEIDVTTNLDLIEQEDAGIPARVPRNLVEKAWFWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8H3</accession>
    <name>G3B8H3_CANTC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115854</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_211728_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="53" mass="6049" checksum="0B43380658FE29A3" modified="2011-11-16" version="1">MYHARTVYSRTSTLLLGYLALSTTLPFALSYKESLEKSQFKGVVHPRALFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8J1</accession>
    <name>G3B8J1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin associated protein KTI12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115198</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8J1"/>
    <dbReference type="STRING" id="590646.G3B8J1"/>
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    <dbReference type="KEGG" id="cten:18247765"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="293" mass="33283" checksum="E347263A1AC9CF8C" modified="2011-11-16" version="1">MPLITFTGFPCSGKSTWATKLIEALEQKIEHAKVDNGPGHNYNIKYHTDDSLGIARKSYRESVSERQARGNQISAVRRDLSRSTFVILDSLAYIKGFRYQLFCEAKGVSTPHCVVHVINSKETVKNWNSSVTNESHIWEEDLIDQLCMRYEEPIDSNRWDSPLFTIAASEEDEQLPIDEIWDTLVLKRPPPPNNATLVKPTSGNNFMQELEKQTSEVIGKILQHQQLSTIGGKVIIDRDNGVVIEMPATTVSIAQLQRIRRTYIGLNRMRSVASDRITPMFSDYVNRNLNSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8M4</accession>
    <name>G3B8M4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_109454</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8M4"/>
    <dbReference type="HOGENOM" id="CLU_210540_0_0_1"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="56" mass="6394" checksum="E823896A12774E6A" modified="2011-11-16" version="1">MSLYQRWMNLPLKARIYIGGSTFFAALAADYVLGSLETEVEARKQIEKELQSTVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Q4</accession>
    <name>G3B8Q4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_115867</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Q4"/>
    <dbReference type="STRING" id="590646.G3B8Q4"/>
    <dbReference type="GeneID" id="18248061"/>
    <dbReference type="KEGG" id="cten:18248061"/>
    <dbReference type="eggNOG" id="KOG0829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080773_1_1_1"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="172" mass="20262" checksum="900D237ADFC8A871" modified="2011-11-16" version="1">MSKFNEYQVIGRRLPTDSVPEPKLYRMRIFAPNVVVAKSRYWYFLQKLHKVKKASGEIVSVNVIAEAHPTKVKTFGIWIRYDSRSGIHNMYKEYRDVTRVAAVETMYADLAARHRARFRSIHILKVVELEKVDDVKRQYVKQFLTKDLKFPLPHRIPKSTKLFAARAPSTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8U1</accession>
    <name>G3B8U1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPS0</name>
        <name evidence="11" type="ORF">CANTEDRAFT_115890</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689092.1">
        <property type="nucleotide sequence ID" value="XM_006689029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8U1"/>
    <dbReference type="STRING" id="590646.G3B8U1"/>
    <dbReference type="GeneID" id="18248072"/>
    <dbReference type="KEGG" id="cten:18248072"/>
    <dbReference type="eggNOG" id="KOG0830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_2_0_1"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="261" mass="28835" checksum="A90ADCD40F182D4C" modified="2011-11-16" version="1">MSLPASFDLTAEDAKLLLAANVHLGSKNVQVHNKPYVYKTRPDGVNVINIGKTWEKIVLAARVIAAVPNASDVAVCSTRTFGQRAVLKFAAHTGATPIAGRFTPGNFTNYITRSFKEPRLVIVTDPRTDSQAIKESSYVNIPVIALTDMDSPSEYVDVAIPCNNKGKHSIGLIWWLIAREVLRLRGVIPDRQTEWSVMPDLYFYRDPEEIEQTTAEEAKTEESEEPATAEGETEWTGETEEVDWAESGANQAAEEAAAQNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B917</accession>
    <name>G3B917_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_107934</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B917"/>
    <dbReference type="STRING" id="590646.G3B917"/>
    <dbReference type="GeneID" id="18245992"/>
    <dbReference type="KEGG" id="cten:18245992"/>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014743_2_0_1"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="682"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="84950" checksum="CD4FAD4FBCF6C0C0" modified="2011-11-16" version="1">MFASDSQLSDLELIDIAIKQLHSIYGATDLKECVSCKMRLQVGKFLALTRSDLVPSVYTRWCKEEGFDESLCQTKFGYPSVEYGALGLEFTKMVQLVNPEGLDGDLYCYYHDQDCHVMPELPSIRMAKLWPPRPKLYEAPKPQGETFNVLHLSDISLQLDYTLLAESNCSQALCCAPRSSNKVHPPPDYDYSSIYDPQFGLSFYDSSYASGHFQKGPYVDQFKTFTPTWLPSHEFGAYGCDTSELMLNNTLQIIRDFHENHLNFEFGIFTGGMVDHADSIHVSRKDVLDSQFRGYRDMLHYLENFPIYSAMGTRDSFPPNQLPTKSLTTQFNYQWQFDFISDLWHESKWIDLDAAKQVRYNQVGYSIITKRGLKIISLNSNVWNTENLYSFIDTLNFDPFGIWQFLIDELIESEINEQRVWIIAHLPPSKHSLPVPTKIFTKIIERFSPKVIAAIFFGYNGKDQFNLIYGGDGQVKDLSNLINYALIGPSVSPLNGNNPAWRYYSVDTETFDVVNSFTYITKLNNTFVNEGAEPVWEYQYSAREAYDPESLWPMERPLDMEFWHHAGEKIRDIPHINKMFNSFEYRQSPYDPYYYLNFQVTEPTTDELILQNDNYCKVTSFSVLNRKECMLTDDQDAYKEPRYLRTFIPLIRPNQSPEYLLLSGPPSTKETESIVYQQRQNPNFDQEEAKQSDVKAKHNRRKSLRDKLHKAHQRVKSEMRKRSFGMELDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B931</accession>
    <name>G3B931_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-binding protein REB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_126446</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B931"/>
    <dbReference type="STRING" id="590646.G3B931"/>
    <dbReference type="GeneID" id="18249172"/>
    <dbReference type="KEGG" id="cten:18249172"/>
    <dbReference type="eggNOG" id="KOG0051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016706_1_0_1"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="373"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="374"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="421"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="423"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="69731" checksum="D743228A64AED085" modified="2011-11-16" version="1">MNNQQEIGGAQALLQLGSKAKGASKRRPSTNPNKTDPESKHQHEEPSSEGHFDHSQTSELEPSGPQDDDIDSKATNQQINDAVEAAVMRYVGGNLDDDKKSKKRLNPDEIISSIGDFQTWSGFLEEGMNDNPDFYDNHNNHNQPTKSPKKKKRRTLSHPSNEIDPELSGLDSNSEHDQLVRAAILETRELAKQLGSTYNTLTNLPAHQAHQVIAALQNNHNGGDSISNINHLVQLAKDQNAEVPNSTIRQFRNFDFKNLESHQNYATTGSYTHIQSVENLSDESQKIAMNWFKDQPQTKGPRPFAPEEQKAVEHFIEGYGYLFKMDRKDICNRIWTTARKKDNFWECLTRVLPYRSRASVYKHVRRQYHIFDVRGKWTSQDDEQLSKLAAVKQGNWKEIGAAMGRMPEDCRDRWRNYIKCGENRVSSKWSSEEEAKLKQVVTEMLTKSKINAINWTLVSEAMEGTRSRIQCRYKWNKLVKKDSMSRIGEMDVDTKLWLFQKIKMLNFSTFKEVDWSLLARMCNEELKQPNKWLPSDFEYGFEKLKSVVKDHKSLTFPELLTQLIQGCHCIRERPGVNKQGSNTDTIDQVHEQTSEPDNDKEYLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B970</accession>
    <name>G3B970_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_115270</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B970"/>
    <dbReference type="STRING" id="590646.G3B970"/>
    <dbReference type="GeneID" id="18247798"/>
    <dbReference type="KEGG" id="cten:18247798"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="162"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="24"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV61827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="332" mass="34860" checksum="6E9F54C7C68B6F38" modified="2011-11-16" version="1">MFTKIATRSFSSSPSAAYKVTVLGAGGGIGQPLSLLLKLNHKVTDLALYDLRGAPGVGADVSHIPTPSTVKGYNPENIGEALTGADVVVIPAGVPRKPGMTRDDLFNTNASIVRDLAKACADHCPDAAVCVIANPVNSTVPIVAEVFKSKGVYNPKKLFGVTTLDVLRASRFVSEVAGTNPVNEKVTVVGGHSGITIVPLLSQTNHKNLDTDKRDALIHRIQFGGDEVVQAKDGAGSATLSMAQAGARFAGSVLNGLAGEKDVIEPSFVDSPLFKDEGIDFFSSKVTLGVEGVKTIHGLGELSDHEEELVKLAKETLIKNIQKGVEFVKQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B985</accession>
    <name>G3B985_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_107523</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B985"/>
    <dbReference type="STRING" id="590646.G3B985"/>
    <dbReference type="GeneID" id="18245958"/>
    <dbReference type="KEGG" id="cten:18245958"/>
    <dbReference type="eggNOG" id="KOG0227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050757_1_0_1"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="10">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="248" mass="28211" checksum="5F0774221CA91088" modified="2011-11-16" version="1">MDYSDRVNSKKGAGGVADAENANVHRKHRVRDLLTTSLLNLDSDPYVFRNHLGLLECKLCLTTHNNEASYLSHVGGKKHQLNLEKRRLLDEKGSRFSTPVGGGVSISTTPKRKWDKIGTPHFKVTKIRDPDTHRMGMLVHVTYSRATAEPLFRFQNYYELSAKNQNVAVSYHDKQAKDTQVAHTPADVRTATAQSQYLVVSCEPYENICVVIPGTSPIINPSTDTKTDEFWWHWDRDVGEFYLQFLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9B7</accession>
    <name>G3B9B7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_135789</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9B7"/>
    <dbReference type="STRING" id="590646.G3B9B7"/>
    <dbReference type="eggNOG" id="ENOG502QQID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_455600_0_0_1"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="599" mass="65903" checksum="7A06F8610CA9CAC7" modified="2011-11-16" version="1">MLSSLVSSVAPPTSTSLPVSHRHRFKQKLTRAFSKPAPLVSDHSLLPSIFPSSLSPLSLTATPTTFFPTARRDDSIHTLKPYYSGSPHSPLSSASSFMSSAATASSATTPFTTPKKGPPVKPYSSGHLPSRPQFSRYRPGVGSSKCFICEELIYTKLADENIIELRCGDFIHEQCLNVSVECSVNKSLESSTFTVSRSRLADLILPRCRGEYCEHLGSSNRVEFLDTSLHDRLLTSAIVKSMEYDRTQLMRGSYAIRRDSAVLASFAAISSSGAMGHGAGADLEPRVGVANPGCAPVSRTSYVQSRSNYEPLPEVYFNTPRNLGPPIDFPSHLDRVESWLSYQTSVRSPSPSITESTANNDTIQMHAHKYISLEVLQDELLQHLLSNYSKITLTTLVKLGTLRLADMLQVRCLEEEDWTQATVYLFENYIVVLKSKENALVCEMANADISFENNLIRIHSHDKSIWLKSNASSILEKWTVSFSDLSFAFPPEFLTSTLHMDGSSTNTRASVLDDSVNIFFERPSSGNSSSATSIQNPMLNVGFGYSEPDYNTIKDIMSTLNVNDSLLLSGPATEADLKSDYDSDSDCDSDEEKIKGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9M2</accession>
    <name>G3B9M2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_125270</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9M2"/>
    <dbReference type="STRING" id="590646.G3B9M2"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003977_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002058">
        <property type="entry name" value="YML081W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="916"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1053" mass="120941" checksum="5540595B03DBD182" modified="2011-11-16" version="1">MSDHISTISDSLVSPVSPVRARSSSASKGTQPIPKKSQQIKTDKPRPHICSTCTRAFARLEHLKRHERSHTNEKPFQCAACGRCFARRDLVLRHQQKLHTNLPNIMGRTGKDGAEGPSMNNEHIIVLPNNTEPNAALPIPLSVAHRSVKSVSAGSSVPAARRSVFSDNKELFPRHSSYSAASSTSYGPMKESFNAIREETTIDNVEFSTPQLNHIDLNFDWNTIESLDLQNSVGHHLNDYGLSFRKDASNMINKNTATPSDYEPSPHTQENYRSPNFKFDSKRRKVDDISPNGTPATSANSKDMNLELDGLSHFKIDMDIHKHNDKGRHHSTPGSVGTPASMKGPLSTQSQGHASQGQFGQIHSNSPMHAMPREHESISDNGDWLQEIINTPYEPVFSNDTAASPKMFDEITSLFKTRQSDLSKHMHSDHHDLQASQHQIPMGNNNQIPNNEDHEKIDANINSYFICDEVRERIMVMSNLSDMQFPKVDELNNYMKLYEKEFNKYFPFIHLPSLRNPMVDKFENIPLLLAMTSIGALYSYNDANTLLLFNLSKYHIQNFFEKEVTLDNLQFKKVPLMAHQCLVLHIFISMFLNEPPMIDITSRQMKSMVGLIKSTNFHKPLDKFLVPPKSIIHLKTNDQNMNIGDVEYDHDTGLVQTNFDYFIMAQSRIRTIFVFYMLQQVRTSTLLDLSILLNGSTISSGNYCCNENLWKCENSSQWLGELMKMNNKQNIIDLSNNGTLNDLIVNLNKFKTMKLSFFNLLCLMVYVHERIQEQFGKLKQQHQNHHHNQFDYINWKLNNQGLKDLLKSWEMNFIKNDGVLIINDMNRHLLSEHNELKLILPMYHLAKIKICVNLTPIIERVVYKDWENMNNYLDHLHLDFDGLKESISYSIDTMDLWNQNILEVNNSIENNLRTPVFFVTCMFVSILLISQFLYYIEQINDKDYGIQLGVTEKILWLKCERILKKCEKTISLNYTQQNLFAEEYENYESIRKLIETNSNSKLIVNSLKLIKLSNKCLFLGVRILADAPIWPLAMGFAEALKNRANYISRTNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA17</accession>
    <name>G3BA17_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115444</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA17"/>
    <dbReference type="GeneID" id="18247875"/>
    <dbReference type="KEGG" id="cten:18247875"/>
    <dbReference type="HOGENOM" id="CLU_897133_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="310" mass="35455" checksum="430B168168AF21CA" modified="2011-11-16" version="1">MSSKKTIPDLLRMFLQEFQSPPFPKEGYLLDVFKNENPVDLELIKENDHLGENLVKSLRLMLMFFQDDLEVPLTDSGSLNSKLSVVKIKRLFELVILNGFELLELEASIITHSGLHYNTCIITSLLNTDLSAVGVHSKTIWCIYNEIVNSFSKADLRYLPLFALFYNQILIKFADSDILQDWLVKRHIVEHFKVFMFDAEKYPAIVQFTGINSYDNSPVIVSQDNFKDIGPDISTKNSSFSGDVSSDFSHMSLSRTQSQFSINTGKQPQPQQEGYQYYQEASNYQDQLPPLQQPQPSVALPFKFADIQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA75</accession>
    <name>G3BA75_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_109562</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPI-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA75"/>
    <dbReference type="STRING" id="590646.G3BA75"/>
    <dbReference type="GeneID" id="18246121"/>
    <dbReference type="KEGG" id="cten:18246121"/>
    <dbReference type="eggNOG" id="KOG1078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010353_2_0_1"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000368">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="20"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="14">
        <location>
            <begin position="667"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="15">
        <location>
            <begin position="822"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="935" mass="104958" checksum="9FC0D2A090ACFAA5" modified="2011-11-16" version="1">MSTSSYKKGDPYSHAGAADKMAIFQECLQQFNATPVNARKCRQLLARLLRLIYTGEVFPSQESTTLFFSISKLFQHKDASLRQLVYLAIKELSSTSQDILMVTSSIMKDIQSGDLIYKPNAIRTLSKVLDPTTVSASERLFKNAIVDKNPIVSSAALTSSYNLLPIAKDVVKRFNNETLETIQSFKQFPPDQFQLHEYYGGATTSLPTTSYMYQYHALSLLYELRNHDKMSLMKLITSLSDGSSLRNSLAVIQLIRFINKVLLDDDSLIQHLLPILINFLKHKSDSVELEACKTIISLQHLISKADFANVVNTLQKLLSVPRTATRFAAIRLINKISVKHPKEIITVNQELENLINDSNRSISTLAITTLLRTIGAGTVESDSTVEVGSESVDRLINKMTSLMDDITEDFKIVIIEAIENLALKFQSKHKKLVSFLTDLLKDEGSLELKSSIVDTLFDLIKFLKDKDGKQAILMSLCEFIEDCEYTELSVRILHLLGDEGPNASNPSYYIRHIYNRLVLDNSIIRSSAVIALSKFAVICGGKVSQNIQILLSRCLNDVDDEVRDRAALSLKFIANNEKNLIVNESKYDLAVLENKLIHYLNNESNFADQFDINEIPAISNEELTSLEYENKLNRLDKNDEMEVEPTSTEGAKDDSNADQSNDLLKQQEFEQEISQVAEFKDYGKLTKSSIQPIYLTEKENEFVVTCHKHFFLETSKVVLQYNITNTVNHLIAQDVSVIAQSDNPAYVEEFILSVDELRPNETGTIYVSFTSPSLAEDELVSVFGNTLSYTNREIIDDEGNIDESDEGWTDEYQIGDLEILPGDFIQPLYNSNFDSVFDQLPLEDSTVVHLKGIKTLENAITKLKDDLNMLPLDGTDYVPSDSNSHILKLFGRDVWGGKVGILVRLALTGGKLVAKLQVKTETEHFSNTIVDGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAQ2</accession>
    <name>G3BAQ2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115527</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688248.1">
        <property type="nucleotide sequence ID" value="XM_006688185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAQ2"/>
    <dbReference type="STRING" id="590646.G3BAQ2"/>
    <dbReference type="GeneID" id="18247906"/>
    <dbReference type="KEGG" id="cten:18247906"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_9_2_1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="174"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="309" mass="34233" checksum="ED138117F4089900" modified="2011-11-16" version="1">MSTIQESKPTIEGRIYIGNVDFKAEEDDLKQFFEGLTVEEVSIPSKIRKYGTKTVEKHLGFAFVQFKTDADAEQAIEKYNGQEFKNRKIYVKKAVPEPTEEEKQKKNELFKAKKAEQAAAKKAKKLVKAQLKKSDASENASEASDAPEGVQKVESKPTEPREPKTAPQGKASDDTIFITNLDYKVNYKTLTTLFKDLSPKWIHVPTRKVPAHIYKIQKAKGRSIFNKGIAFVKFADHDTQVKAIEEFNGKEVNGRNIIVDVAVDARIPTEASEGSEESVVPEAAAINGDAASEATDVDALPEPASEESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAR5</accession>
    <name>G3BAR5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_125610</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAR5"/>
    <dbReference type="STRING" id="590646.G3BAR5"/>
    <dbReference type="GeneID" id="18249110"/>
    <dbReference type="KEGG" id="cten:18249110"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_0_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="296" mass="32951" checksum="8B7DAC1D1BC20CB2" modified="2011-11-16" version="1">MVLAKPLNVALIQTLPTVDLEANLKRVDELVEKAMTEKPETEMIVFGEHFSTPLGKEYYEKFAEEVPGPRSEMLCNIAKKYKVNVIGGSFAEKYKDTLYNTSLSFDKTGNMIGYHRKVHMFDIDIPNKITAKESDTFTGGTSATLIKVPEFGVVGEGICYDIRFPELAAIASRNDAFCMLYPSAFNTTTGPLHWSLLARSRAIDNQVYVIMCSPGRNPDFSYPVYGHSLIVDPSGKILVEAGDGEEILYSTLEPEAIASFRRNIPLETQRRFDVYKDISDGAVTACIEVQDTDSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAW4</accession>
    <name>G3BAW4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_135418</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAW4"/>
    <dbReference type="eggNOG" id="ENOG502RQ27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_524769_0_0_1"/>
    <dbReference type="OrthoDB" id="4096810at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="519" mass="57905" checksum="D1EFE0F678DDA197" modified="2011-11-16" version="1">MSDLEESRRSRSRVRGGLNKSFRIQDETIHTSTNVKQPSEAYHDRPHRSLSRLSQATSTRSTNSDNQLLQQALQNQNLRNSESHKLTGKAHPKASDITIDVRPAIKRWNSIQYLPQDSKEPKNIGDPTSLSPLTVIKDQYNTRMPVSNYAAATDNYYRDLDGNDAPPQPQPIKDLKLAEVSSPPPDSITNKIYNKMVKLLHSSNTSTFTDTDRLLESGPSLHPKSSLATNTTSLSKYQSESDDESEEDLTTADRDEAFDSWASPNVNLNEGTVLNDININSIMDEINDFQSNFVRKYNATTPQDELVSSSSRVQQKILDHRDLHSQESDPVSSSSSYFSLKSINSSLNQMFGDHNFKIQHETISSQYNQIRFRFACNTDISLYTIGGEPVDSCDKSILSLRSNIGPLGFLNRQKLLASHGLGVLAQSSSSPECHTDLGIGDTDAYLKELWKSEMDSLFPETQAPKTPQTPQFNEGTALPSPIQSQRPDSTVRLSNRSSFEVIKSNTSFAELAGKVRLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB71</accession>
    <name>G3BB71_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_135451</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB71"/>
    <dbReference type="GeneID" id="18249878"/>
    <dbReference type="KEGG" id="cten:18249878"/>
    <dbReference type="HOGENOM" id="CLU_836777_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="332" mass="37357" checksum="91B3A5DBCD06FD9C" modified="2011-11-16" version="1">MDDFNTTQEVVSHICVIRAYITVKTYGSQLEGRITKVMVVPPDSSEWETAPQLQDLGKQIKAHLYGPYANEVRRAIPGKLLESVSHSMSRMESDRIRNQRSNNSINSQHPDDRTRSPRLKQTSARVISTKVGLEPKKETLVKSENLEDGIVPGNHFDDLVDDNEEVDDESYQQDPSQVTDSLASQKRPSSPSIAFRDDNTMTIKNLKNISLTIDNIIYRVNAKVLGVVPEAKHICVKSFAVNADGTPEAQDPYVRPFKVIISDGETLDIHFDGKQLLEMVKVSVEELYAIPTMLEGLLEGIFGKVRHFRLFKKRIPLNGNVSIVVWTCKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBC9</accession>
    <name>G3BBC9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115625</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBC9"/>
    <dbReference type="eggNOG" id="ENOG502S2HK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148825_0_0_1"/>
    <dbReference type="OrthoDB" id="4083608at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048:SF1">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10919" checksum="BAB41DB423E7F45F" modified="2011-11-16" version="1">MVESNILSIFKTSQAPTLIEEDCIPCTSMQSATALGMGGYLLTDRIYTEADGTIDGRKHPKWWRNSVKTSGVVLVMFGVQRLYRVYEIYQDQRPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBE0</accession>
    <name>G3BBE0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115633</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBE0"/>
    <dbReference type="STRING" id="590646.G3BBE0"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040688_2_0_1"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="327" mass="36629" checksum="9C48CF1EC7FCE632" modified="2011-11-16" version="1">MNPFQTVLNGLGDRIPESPPIHQSPNSNQSGHPQDHDNHPQNHHPQTHDQQNHNQQNHNQQNHLQHHHHTPNIHSLLSPDPAQLHQAPAPQQTEEDHRFFKLAKEAIVATAKATAQSAGPNKQILDPTLNDLFMRLQYVSSPHGNPIKNGENIQVNEKGQLMIQDFYQNFPNLNNDIFQTPGTGTSNGHASGASDTTSYWNSSRQHQGGNRNPLIGANPLIGVPSYSHESTAVSATATGEERRSQSPEERKFQCSRCTMNFKRSSDLKRHENQHLTIPPNICEFCGKGFARKDALKRHVGTATCKRNADKKLYMDNLLLRDEFGGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBE3</accession>
    <name>G3BBE3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ras homolog type B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_115635</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBE3"/>
    <dbReference type="STRING" id="590646.G3BBE3"/>
    <dbReference type="GeneID" id="18247944"/>
    <dbReference type="KEGG" id="cten:18247944"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_0_1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="190"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV62807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="233" mass="25590" checksum="F9A96E58AAF9C6B7" modified="2011-11-16" version="1">MIKEYKLVVVGGGGVGKSALTIQLIQSQFVDEYDPTIEDSYRKQYNIDGEQVLLDILDTAGQEEYSAMREQYMRTGEGFLLVYSIDSKSSLDELTNFYEQIQRVKESDSVPVLIIGNKCDLENERQVSYEEGELLAKSFNGCKFFETSAKQRINVEEAFFELVRSVRDGNKPAAVANEAAAAPVAAAPVTEQVKESSETAANAKAAPDGQRKQQTKPSSGNESKESSGCCVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBF2</accession>
    <name>G3BBF2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_95066</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBF2"/>
    <dbReference type="STRING" id="590646.G3BBF2"/>
    <dbReference type="GeneID" id="18250474"/>
    <dbReference type="KEGG" id="cten:18250474"/>
    <dbReference type="eggNOG" id="ENOG502QRKD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028484_1_0_1"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="581" mass="67866" checksum="47815128FE305010" modified="2011-11-16" version="1">MLRSSRLIVRRGLFNGNKLAKYNENDTSFNHEYSIRPDTFAFKVSGKQVLYNNRISPFQSLKNSKFNMLDFVYRNSTNYPFAEKTPQEVFNSYPPVNSKKLARNKHRPKKVKMAVGDFIEDSLYNPNYGYFSSEVEIFKSDKPFDYNNIEDVDDFMENWRSAYSKYDQEEVEIKRKELIKPDEKNYANPNSKYASYSLTLYNEEKQKLRPVQKNKRSLQLWHTPTELFQPFYGEALAKSIVHKYKTDAKFSGKNLVIYEMGGGNGTLMVNILNYIKLNEPEIYKTAQYKIIEISSQLAIKQYNQALGSKLVAQNLDASKCEIINKSIFEWSETVQDPVFFIALEVFDNFAHDLIRYDNETGEPHQGYVLVDDKGDFYEFFTPELNYYSESFLQLRENGEQGLLGKKNTIKGRWKGFKSSIPFINKDDIHPLHHSRKKLLWHNTILPFKDNLSPGEFIPTRLLHFFHVLQHRFPNHSLVSSDFNFLPSTVEGYYNGPVVQTVLKDRMIDISTYMCNQGYFDIMFATDFQLASDLYRQVTGKTAQVESHKGFLQKWSDLKATNTKRGENPMLEFYTNVSFMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBQ9</accession>
    <name>G3BBQ9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_125860</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBQ9"/>
    <dbReference type="STRING" id="590646.G3BBQ9"/>
    <dbReference type="GeneID" id="18249135"/>
    <dbReference type="KEGG" id="cten:18249135"/>
    <dbReference type="eggNOG" id="KOG1876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084855_1_0_1"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="171" mass="19854" checksum="FF0605CC5158D44D" modified="2011-11-16" version="1">MSQSLKPYLTAVRSSLTAAICLEDFSSQLVERHNRPEIEVDNSHNPELILNPMVIARNENEKVLIEPSINSVRVSIKIKQADEIEQILVHQFARFLTSRAENFFILRRVPIKGYDISFLVTNFHTEQMLKDKLVDFIIEFMEEVDKEISEMKLFLNARARVIAEAYLTPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC54</accession>
    <name>G3BC54_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_137262</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC54"/>
    <dbReference type="STRING" id="590646.G3BC54"/>
    <dbReference type="GeneID" id="18250048"/>
    <dbReference type="KEGG" id="cten:18250048"/>
    <dbReference type="eggNOG" id="KOG1729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012484_0_0_1"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="646"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="569"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="784" mass="85787" checksum="687D3A5353A486DD" modified="2011-11-16" version="1">MCISYLSETKTMCPYTNNSSCCLHVHLPLCEMDQRLCHHTTGCSHYPNLILGAKTPKFTLSSSNSAEELRPGAVSASPTAPSSIPNGGSHTSSETSAIDNTIIPSPPAQLQKLRPTSVIPGENTDISPRSQAIPPPTTQSTTDSQIKGVTHHQPVASSRTSHSPSPRVGTASVGHQHHGAANVSDSDSHNDNDNDSENGINDGNSSNDENAINDNEADPEATNPINFLQFKKKNVKPRTQSFQSVLSTASLKSLTQPPIHRNSSIISSISNVHNNKNFQSYIQAPVLSSISNPRKDEIEIGRQLPFDHKSHQEDQQQESNDNDTYEDPLIQQQQLTLNALKKLSLSPLPRIDNDNFDETTDTRARKSEPYQPAAVDLSTFASLTRQPNVNQRRLSGASEMADSLKPLSTSTSVPNSAGSTGSQVSIQSPLQQLQTVQRSSTNGDISNQSYPNKTKNTLLNDLTQRRRSQNSPMTLVNRIPSPRSIGASQGLPQVNNTPSNPPIQQTTQHPNPPPANAVSYFPVPQVHSPAPSGPPIKQKHLQHIKGLRSPMYVPAVLRKTIDEESGEPSTAISATSSTNNDSSAASMRSVDSTLSVDSRSSSPVLSPSSTSTIKNFKSYEHFLRQPPSRKHWLKDETVYKCGITQCPREFNFFERRHHCRKCGAIFCKEHTSHFLYINHLAQFTTGGRGTLSRVCDGCIGEYNEFMKSQFGVNLYKNGDTTPRTSVGNESWAPERNAAQPKQFYERQSFTATDIPTSALNKDLKDGRSETIVGSVPANWSWSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC96</accession>
    <name>G3BC96_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">triacylglycerol lipase</fullName>
            <ecNumber evidence="1">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_127092</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC96"/>
    <dbReference type="GeneID" id="18249217"/>
    <dbReference type="KEGG" id="cten:18249217"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_3_0_1"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF3">
        <property type="entry name" value="LIPASE LIH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442636" description="triacylglycerol lipase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="347" mass="39405" checksum="FC179E8A209CC8B9" modified="2011-11-16" version="1">MFFLVFSILSLPLVVANNVWSPVSNHTTPVANIPILPVPEDYKKLVEFANIVSFSYCTQFGLQAGKLGEEDSHCPGVRCKYPEFSNIEVLRTFDFNTLKSVGSGFYGVDYQKKRIILAFRGSSTKRDWFANLDFIQKPYQPLFNLLDKKKAAEKVDCNGCMVHRGFYNFVEEHCKTVIAAVSELKQQLEDYELVVLGHSLGGAFALLSGIEFQLLGYNPLVVTFASPRVGNKKMMRYVDKIFNSEKIQILSQKQKQMSKGFIRVVHKHDIVPMLPPSRISYVHGGVEYLITSTKLPHLPKDIQRVGVYNYDDSKSVSADLDKILRIIPEIFTNFEHVHYFVKISGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCC2</accession>
    <name>G3BCC2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116869</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCC2"/>
    <dbReference type="HOGENOM" id="CLU_2922413_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="61" mass="6403" checksum="5B45AC2E22CBC51E" modified="2011-11-16" version="1">MAMRVVHAAAVSEFPSSSLEAYSEPVPNSPSVEPVAIKQSGGAYERIARGISGSNVRGRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCH9</accession>
    <name>G3BCH9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_111774</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCH9"/>
    <dbReference type="STRING" id="590646.G3BCH9"/>
    <dbReference type="GeneID" id="18246313"/>
    <dbReference type="KEGG" id="cten:18246313"/>
    <dbReference type="eggNOG" id="KOG3463">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112964_3_1_1"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="10">
        <location>
            <begin position="66"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="120" mass="13581" checksum="BF6DEB436FAD87E2" modified="2011-11-16" version="1">MSAPAYYELYRRSTVGATLTDALDQLISDEKIQPQLAMTIVTNFDRVISELLKPEQNIAKSKLTFKGDLSTYRFCDDVWTFIIKNVLIKLTDTSHSELNDEVTVDKFKIVACNSRKAGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCJ3</accession>
    <name>G3BCJ3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_136670</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCJ3"/>
    <dbReference type="GeneID" id="18249990"/>
    <dbReference type="KEGG" id="cten:18249990"/>
    <dbReference type="HOGENOM" id="CLU_1304708_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="211" mass="23728" checksum="2FAA0E1C8C165F7C" modified="2011-11-16" version="1">MSLQRTTLCTPTATFICQYISMVQHKTHGIEKPKPDPNLFVEDGIFGKYKAVLQSDFRVVKMKGMLKPYKEAAVLKTLKRQTLKYIKTSNSIKLIFPDYSYCLCSPDFSNLRFVHYQSANSPITPSEAFSIPSFGKNLTHIEDGAHLFMDLPPQLSPIPEFYMSTSQTASSQQDVMDIDFASDEYSSSTESDSDFVQDVSKSVGKLALYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCV8</accession>
    <name>G3BCV8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116272</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCV8"/>
    <dbReference type="STRING" id="590646.G3BCV8"/>
    <dbReference type="eggNOG" id="KOG1312">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042181_2_0_1"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442641" description="Palmitoyltransferase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="141"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="338" mass="39341" checksum="806082C73D49FC5B" modified="2011-11-16" version="1">MLLSGFLALVIILLIVILVFGDSPSFRGSWIQKARLVFLRYNSRALGHISSLNHPLFNWSVPIFYIGTLSFCLFQFFSCTWKLVPAVIKYSFVHQISIAFTIASVYFTTLVCVVSNPGEVHKYNVQTANSKFHHNDIIYFRNNFCRTCKFEKPARSKHCSTCGNCVMMFDHHCIWINNCVGYYNYRYFILWLVSNLTILAYGAYIMAQVIPPRQLAHSIKIDRDHKITGCLMILCVIFDMVVAVFTGLQFRYIYLGITTNELDKWGEIEYLVQISSLYKRNGEYLELVDNQLINMQNTQVFPFYNDAVKVSSVEEIDNIYDQGFKRNFHEKFFPQYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD38</accession>
    <name>G3BD38_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantolactone reductase</fullName>
            <ecNumber evidence="4">1.1.1.358</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-dehydropantolactone reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ketopantoyl-lactone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_116956</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16719"/>
            <dbReference type="ChEBI" id="CHEBI:18395"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.358"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>isatin + NADPH + H(+) = 3-hydroxyindolin-2-one + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27539"/>
            <dbReference type="ChEBI" id="CHEBI:28536"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.1.1.358" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690513.1">
        <property type="nucleotide sequence ID" value="XM_006690450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD38"/>
    <dbReference type="GeneID" id="18248520"/>
    <dbReference type="KEGG" id="cten:18248520"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047011">
        <property type="term" value="F:2-dehydropantolactone reductase (A-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00051098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="286" mass="32041" checksum="91DFDBEB16FD1C6D" modified="2011-11-16" version="1">MTTITLNNGTTIPQLGLGVFLTPQDVAKPTVYSALDIGYRHIDSASKYGNEQQVCEGIAQWLKDNNQSRKSVFYTTKIWNSDHGYQACKKAIEVCLKNASSIGYIDLVLVHSPLSNAEKRHGTWLALQEAVDAGTVKNIGVSNYGVAHLQELLAYSDLKYKPVINQVEIHPWLTREELVQFCRENEIAVEAYSPLARGKNFGDEYIVQLSKKYNVTEAQIMIKWSLAKGYIPLPKTVNQDRLVSNFDVYSFELTKDEIAQLDAKDVYGITGWDPTKFPLDADADAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD56</accession>
    <name>G3BD56_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-ketoisocaproate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116306</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD56"/>
    <dbReference type="STRING" id="590646.G3BD56"/>
    <dbReference type="GeneID" id="18248238"/>
    <dbReference type="KEGG" id="cten:18248238"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="120"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="343" mass="37412" checksum="9A40089C408C3156" modified="2011-11-16" version="1">MSTKPKVLWIGAPFASGAGWDELSHIADVQACTSKDRQEFIQDLKGKYNDITCIGRTFNMAQTGRFDEELVSHFPPTLKAVCNSGAGYDQVDVEPLIKRNIQLSNVTTPVEAPTADTAVYLVLATLRNFQEGHDLMVKGKWVPGVKSAGSKLGHNPSAKVVGILGMGGIGRAIRDRLVPFGFKKIIYYNRSKLSPDLEQGAEYTSFDDLISNSDIICVSVPLNPKTHHLLDAKVLGKMKKDVIIVNTARGAVIDEAAILDKLQNNEIGFFGSDVFEFEPKVSQDLLNLPNVVSLPHMGTHTVEAVLGLESFTVENIDSVLRSGKVKTVVPEMAKIDFGHQPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDM7</accession>
    <name>G3BDM7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136821</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689556.1">
        <property type="nucleotide sequence ID" value="XM_006689493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDM7"/>
    <dbReference type="STRING" id="590646.G3BDM7"/>
    <dbReference type="GeneID" id="18250010"/>
    <dbReference type="KEGG" id="cten:18250010"/>
    <dbReference type="eggNOG" id="ENOG502RPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042318_0_0_1"/>
    <dbReference type="OrthoDB" id="4082978at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="480" mass="54998" checksum="DA1719621F0B1D35" modified="2011-11-16" version="1">MEQLSQSVIGGGDEYLVPEPINQVPVKRLFDFQTGKLKESMKLPKDFELDDSEILFKIKLIAVNYGRDFELMKQYNTETSTSGGRILPSNIVPCNKFIGKIYASNDVNLDFELDNSKFLVFPHTTCIQQGFPTLCKNCTHYLSSHRSAVGTSSFLPCLARFEFGYNVDGGLQDFIKIKNSSEILIKVPDNVSTHDAALSLDISLPFYSYFKWLQNSGNYNPTDKILLVLSDSRKEMNDVLVVFKMLQLIEKNVTIIDAPQIKAMTPSEENTFSSHFNMVLTFDFNHRVLNFCFNSIISTGLESTKSRYRFVMFNQYFPVDFSNYKQFDLTDKVITEFKLNWFHKFDLIDLLSYLSSLNNSTPRKSLSSVEDSTTKSPTKSVFSDASTTSETTSSSTKGKTEEDYHNNRFVKSHEINELLSLPSKVHWLYYEKDVDLANEFQKTDNSHSTRHINKLMKSNKNVKICYNNRPNKSKVNAFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDV3</accession>
    <name>G3BDV3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116440</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDV3"/>
    <dbReference type="HOGENOM" id="CLU_2183622_0_0_1"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="109" mass="12568" checksum="6EB3FFD27A176255" modified="2011-11-16" version="1">MLFELTNILGPQILVGLNRLNFILNQMITSPYLLETSPLTVQKVLELQYTILSAFDEAETEAKQLVFEYRFDLLAAWSVLSRRSETNVSKQMEKLGEISRELNCELEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEA5</accession>
    <name>G3BEA5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plectin/S10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116560</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEA5"/>
    <dbReference type="STRING" id="590646.G3BEA5"/>
    <dbReference type="GeneID" id="18248356"/>
    <dbReference type="KEGG" id="cten:18248356"/>
    <dbReference type="eggNOG" id="KOG3344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089349_4_1_1"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="116" mass="13723" checksum="4B60D4BBF1711002" modified="2011-11-16" version="1">MLIPKEDRKLIHQYLFQEGVVVAKKDFEQAKHDEINTKNLFVIKALQSLTSKGYVQTQFSWQYYYYTLTDEGVEYLRQELNIPEGILPLTRLQGAPAERPQRGGFQQRRGNFKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF03</accession>
    <name>G3BF03_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_126700</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF03"/>
    <dbReference type="STRING" id="590646.G3BF03"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="153"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV59978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="375" mass="43341" checksum="D69CC56AAC5CDFD5" modified="2011-11-16" version="1">MLITHPRVMLMNVQWMDATARFCGSLTSLFPKVFFSTVNIWTLYALLSEVCYNQISLQSERPGVAILVGLIGVFLHVMCAYTYFMVVIVGGGSPSDFPELRIRNLDSLKANSQDPPEFQEQDQLLGDTEADVYRDVPPTQWVDFHITRPGTSPYRYCLKCKVWKPDRCHHCSSCNRCVLRMDHHCPWFATCIGYHNQKLFIQNLMYIGMYSGFCLVVSAVYLFSFFHHQEYEAGYLSLRLVFLFIVSLVFFVTIGVFGMFSMWLVFRNTTTIEFQDQRWSWGDKASSRSSGPNIFDLGARNNWVSVMGNHWVYWVLPVQFTQKDIASPVNGINSVVDEEAYDEWCQSVRAQEQLNKQLREYRDGLRGVEGEDRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFN8</accession>
    <name>G3BFN8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116091</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFN8"/>
    <dbReference type="STRING" id="590646.G3BFN8"/>
    <dbReference type="GeneID" id="18248163"/>
    <dbReference type="KEGG" id="cten:18248163"/>
    <dbReference type="eggNOG" id="KOG4077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099086_0_1_1"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="151" mass="17700" checksum="534E32CD6F5A92C0" modified="2011-11-16" version="1">MFASTVRSALRVRAIPRAHLHSLATPANRFMISQVAVRQVRNYSDDHHEESFEEFTARYEQEFEEAYDLFEVQRILNNCFSYDLVPAPAVIEKALLACRRVNDYPTAVRTFEALKHKVENKQQYEAYLEELKDIRQELGIDLKEELYAQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFU7</accession>
    <name>G3BFU7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_128289</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFU7"/>
    <dbReference type="STRING" id="590646.G3BFU7"/>
    <dbReference type="eggNOG" id="KOG4568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031641_0_0_1"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="359" mass="41209" checksum="056AF323E6AFF4AB" modified="2011-11-16" version="1">MVEHIGSQVNVPGTRGKGILRYHGSIHGKTGIFAGIELLGPIALTRGKNSGDVEGFKYFEVQSPMSGLFLPFERLKAVNPQIDHTRDMINEATLNFNNDTLDDEIPTFSGLSSPNYSLQPILKQYESELDERDRKISKIRNEFESAREDWRQNLDIMVNTYEANEAYYETKIRELQSKEIKALQQQLDKTNSTKLLCERENTIKELEQKLGESLSKELDSLNINDAAAMNEMTFREEVEQLRLQLDARPTIEELTELQDNIDEMVRLHNNEVFFKQEELQRVTNENSKLQVRLERALEGSIITNRISDNTSHDSMTINSLPIYKPENDTDPSTGKDNWCGLCERDGHNSLNCPYENDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW23</accession>
    <name>G3AW23_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_128847</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW23"/>
    <dbReference type="STRING" id="590646.G3AW23"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="46"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="537" mass="58896" checksum="048CF5EF2B0F96F8" modified="2011-11-16" version="1">MSASVVSGQEKDKHQVVYATQEDVGSLKENESDAGETLSKSLTSRHLGMITLVGVFGTGLFLSSGGTLATTGPVGMLLAYILVGLVVGASQMCITECACFMPVTSGYVRHSEHFVDDALGFMMGWTDIYSSIMPSELSAAAVVVQYWTDLSPAIFITIFGVACIATNVYNVRWYGEIEFVFGILKLSLIVILIVTGLVIDLGGTGDRIGFRYWKDPGPFNAKYTTGSLGNFAAFWKTVSSVVYAYGGVQAIGLLSGEAEFPRRAIYRAAKRVFYRVFTLYLLTVFVLTLIVPSNNETIASPNGTAAASPFVVAMQGQVKVLPHYINAIVCTSAFSAANIGIIKASRTLFALAAKGQAPKLFLKVNKHGLPWVGVTFACAFIPLAYMSVSSGSKTVFSWFQSITSSNLLLNWILISVNHIGMTRAFKAQGYSRKLLPYKFKGTVFASWFSLFFSVLFLLTGGFTNFIHGQFDFGSFFGAYFIIPLSIILYFGYKLIKKTKLKDPKKVDLKSIFRDIELYPEPEYPKLKGWEYITLLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW25</accession>
    <name>G3AW25_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prolyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_100705</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW25"/>
    <dbReference type="STRING" id="590646.G3AW25"/>
    <dbReference type="eggNOG" id="ENOG502QSNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024518_2_1_1"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="63"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="467" mass="53549" checksum="6AF53BE5149627B2" modified="2011-11-16" version="1">MGTSYQIEETYRVQNIKVDVLKFSLPLSYFNDDYSGQEISVFATLCQKFDPEVTDLLPKVPKVVTFIQGGPGYPCSPPATNIPYTNIFIDRGYQVLYMDQRGTGLSTPINSTSFPQLIPKTSESEVNYVVKQLHYILNFTGASIVEDLERIREILLKTRKWSISGQSFGGFCSFIYLSKYPNSIKESFITGGVPPINHGPDDVYRSTYKRAKERNIHYYSKYPQDVTKVNTILTYLSTNKTSLPDGGNLSVERFQQMGLNFGQHGGTDKIHSLVQYFYNDLKMFGAPSFNTLTSVLNSLHFDTNVIYALFQESIYCDGNNPQVKTSNWSADRLRYLPENTSFVFQEGREEPTFFTTEMVYKSMYNDYVELRPFKGLAFALHLNTQWPKLYDIETLRTLTFEKVPIVGAVYVHDLYVDFDLSRKVLEDTFGGRNFRAFMTSEFFHGGYLKDPQRVMGTLFKLLESEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW43</accession>
    <name>G3AW43_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_91613</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AW43"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262908_0_0_1"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="133"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="307"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="824"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="960"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1036"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1096"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="701"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1112"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1185"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1283" mass="140179" checksum="EE61419C9F7BFA01" modified="2011-11-16" version="1">MPGDDTYLPELNLSEIEALKDGLKYFKVSQLRELSRSLGVRQGKKKAETIENIRAIIDRFLKPFDKVSLVTIIVLTEMLKARPDLPVFASLYRGLETGTVNYQSTLQSISALKSSSVPNYRTHPTNIKAVSKKAPPTRSPFTLVFEPSPFHELIKDLPEFPGVGYGSATRSQILMNITLSPEDRELLKDPSNRVYLRCTNFDKVSVRTCSIEYPDKMELSVNGQTIKESGVRGIKNVPGTARPFDITDHLKQESNSIKLLFIDKNPFMLIGSICKKFSITEVLQKLNMKRIPKEVEIQKIKASHDNTDDDISVGIEKVSLKCPLSYARIRLPVKSEQCDHTGCFDAYSFLALQEQISTWKCPICQKRISAEELRISEYFEDIIKSSKIETEMVMLAEDGGWIEQMQDDDDISETDSSKHMVREPAKDESMIETIVLDSDESDEESAEDPPETALSDDLDDIPIAAAAFRHVPRVISDDDGEGNIEQPTESPHPDKVRGSALSGDSLGDTLLDAPGRSEQPVEMLSDTPAPAAESETTPQNQFQPTQSPSDMSVPSAPNTQVVPPVHQVSATTQNKLANTAVHDISKEVNTGQVNDLAPLPPPPFPPPVRSNSGEGSHLASHIVSGSEAPTPTPASVKDSRPGPAPNHVHVPASTAASDPERNGTIHDEGVESEPNSSRPQQHRSKPKTRLPSTKAEAIVPPTNQLQFNTEGSTPMLQSYQAQYNRQASASTSPPNQFQYTRHNIMSSIPSNQTQYDGQGNLYIPPPNQGRMDWFTDHSGGPSYIPPPIGHFDRPSLPAQGLYSSAQRVPGTQVITKILPRPQNEDLTSEAPIGRDTGKEVSNTVVDPPTNDEYRSDYSHMSHYPHASLVPRATSLFGPSSVLLSGPNNQSHRTREEQMTCGSTQIPNRAEPMSSGQIVSLPSLNLMVGEGQDKLSTSLPLRPIQLPSDSVAQVHSNNVRSGIRNGTSFQNFSSRSSSITSPSSGETEAQANTQKKESSTPNHMVRSHRSYNLISNILSEQDRPSTSSTEGQKDLVIAQSTGGNGRTTGNSSAQNLSKNTEIPPTTHQDVPENTGLSSGASQVQLLKEKIRSYKQNQIGDIDGAPEDVFPEPSRNTSGKGAQHVNQPADSAQSSTSPKGLNEIVSTDPNRNGPSKGSKTVVENRDDFVWVDGESNEPPRMAPVAPSQKTLPHTSINNQVIENPTSERNAESSNYSTSKPVQANFSNINPVQKHQNDSDNEEAITPMKKKTKTMGLLGIHLSDDPRDYSISPLNGKVGEMNLNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW54</accession>
    <name>G3AW54_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_91622</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW54"/>
    <dbReference type="STRING" id="590646.G3AW54"/>
    <dbReference type="GeneID" id="18250096"/>
    <dbReference type="KEGG" id="cten:18250096"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234848_0_0_1"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="224" mass="25358" checksum="43BC36711E2D632E" modified="2011-11-16" version="1">MPVTERPKTSDLKVNFGPAEALVIKSLSGSLGAKGKKGACDPFDKQPSDDTTDESSIISTDTPEMDELKPLKSIINSDSSVPTPLRSFDILSFNNSRYETPRFFNDYLSPNSKFSGMQQSSKNKHKIEVEFKHVDLTNSLVVGFLKIQGLSDEHPEITTCFKGEIINNPLKTRYDKSLAKNYSFLTENSQWGSSFTNDLDHWKRLSNYYNLTDDEFSKKLFFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWU2</accession>
    <name>G3AWU2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAGA complex subunit Spt7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_117718</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWU2"/>
    <dbReference type="STRING" id="590646.G3AWU2"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006198_0_1_1"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05510">
        <property type="entry name" value="Bromo_SPT7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000032">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="366"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1100" mass="126834" checksum="3E4F8AD504C7E353" modified="2011-11-16" version="1">MDKLVSFQVNDTRKLFKLSKKLNETKFFKNFLNESQSKLLSYLIGLDNFTIWGNFIEGNVYFKVSSTSEPNDSSHLNDDIDVDIDIEDGSRTAKRMASHIRYLLYEKAIDFYYFSKNLDESSNAIDEVNDDYDLLDSLNTESRADASNEQQKEVEKPVVREEDDDYDDDDDDDDGEAQAQDNESSKMNVDTDNENIQFNEENQLILEVPSSIFAKDEQTSESAEDQQESNSENLEDQENLIKEFNKVYHNFEYDRETLIKRRRLEKSDMKLEKTSAPENKNDQSTTYSNSNDSGSGIEFAFATGSSLKHLLGTIQAKRDQIPLNDYELRTLFMDVKKNRGKWANDDRVGQEELYDACEKVILELRSYTEHSTPFLNKVSKREAPNYGLIIKTPMDLNTVMKKLKNLQYNSKQEFVDDIMLIWSNCLLYNSDPKHFLRAHAIAMQKKSLKLIPHIPNIVIKLRSEIERDEEKDDINNDTSKGKSSKKGRKRTRNNDVKLEHESTAGSPESAVETPVEDEKDETPILVEPTPVPEVQTSATTAVTTAPVEEEEEEEENDEINEENNTNNNQNEDDEGDPELQAWKTLTAKSRAHYCSARAELFHEDDKFKLNFDAPAILREPNEMANFNEYITNKQVVSKGNLLENDEPYLLEYDITGGLPGLVFKGVDNQEQERHEQKIVDSYIANKMEQSSSQFVLSTENGLNSVYLKNITEMQEIRRICFKISLVRQMQTQQFVHHTQMRQPEIEKIKEVDLDPISKLENHEEFDKEIQYSVLRRNVAKMIMQTGFESAEPFAVNTLTQLAERYLSNLVNSVKSHSETISKNRLPKSEVLLVSLIENGVNKPDDLYTFVNERLLTQYNKLIDLRAKLSNFLKELLRPGLENFNEKSFNDNSDQFMTGDFSNDLGDDFFGFKELGLDKEFHMLSSSIPVYLLHSRLRTSYASDGATSKSQKYDDLKDYKVNKLYGTDVDKQIGILRPFYHKLLEKSKAHFIKVQKKNGLSMELPEISKLPLIDDEELPQKQRNIRPRLPPTGKITSIKKRPLASSFFLPELEELKVTKQEQNDDISQHEDMAAIPLMSDDPFNDDIDAKEIELMMSNLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX91</accession>
    <name>G3AX91_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-glycosylase/DNA lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_91890</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX91"/>
    <dbReference type="STRING" id="590646.G3AX91"/>
    <dbReference type="GeneID" id="18250124"/>
    <dbReference type="KEGG" id="cten:18250124"/>
    <dbReference type="eggNOG" id="KOG2875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027543_3_1_1"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000006">
        <property type="entry name" value="N-glycosylase/DNA lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="14">
        <location>
            <begin position="138"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="363" mass="42039" checksum="B1A41ED336EBC01E" modified="2011-11-16" version="1">MTIDIVWKSLPLKPVELSLSRVLRCGQTFRWKNIDHVWSFTTSDRIVLLRQDEEHLHYSWIMEEDNKTMKPLKLRESETLEFIMDYFSLSTSLEKLYSDWSIVNQKYNKSVKNSPFVKFPGIRILRQDPWETTISFICSSNNNVKRISKMCDSLCSEFGKFINVYGGESFYSFPDPSSLAKPGTEQKLRELGFGYRARYIYNTACKFVDDDGFPHITTKTLHAMRKSPYEEAHEFLLLLDGVGPKVADCICLMALDKHEIVPVDTHVYQIAIRDYRFKGKRDLKTMNKQVYEDIRGFFKTLFGPYAGWAQSVLFASDLADLNNGINQITDTTTIKTEKVEVDKRTVDFAETKVVKSKRIKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXG6</accession>
    <name>G3AXG6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_112115</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXG6"/>
    <dbReference type="STRING" id="590646.G3AXG6"/>
    <dbReference type="GeneID" id="18246362"/>
    <dbReference type="KEGG" id="cten:18246362"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_6_1"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="3">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="103" mass="11205" checksum="620D7E216BCE692D" modified="2011-11-16" version="1">MVATITKKEEFDEALKHSGLVVVDFFATWCGPCKMIAPMLDKFSAEYTSAKFIKVDVDDFGQIAQEYEISSMPTILFIKDGKVVTKVIGANPAGIKQALAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXS9</accession>
    <name>G3AXS9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_133093</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
            <location evidence="5">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXS9"/>
    <dbReference type="STRING" id="590646.G3AXS9"/>
    <dbReference type="GeneID" id="18249668"/>
    <dbReference type="KEGG" id="cten:18249668"/>
    <dbReference type="eggNOG" id="ENOG502S85C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507258_0_0_1"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015280">
        <property type="entry name" value="Rap1_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09197">
        <property type="entry name" value="Rap1-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="571" mass="65002" checksum="4FAA4D04A304FB4D" modified="2011-11-16" version="1">MVKTPSDLFTVGERPLLAFMPKDDPERDTYVKLIEDNGGIVTSSVPNAKNGVMFISSYPIDGFHPIYRASWVDHSISNGKLADVNPYVFPVKKETGGRKTVKYTQAQDEYILEQIRLKPLERGSHRFFELLEGHEELKGHTKHSLRSRYRRHLVHNLKYVYKVNEHGKLILDEYGNKIKVSPDSYPDLKKRFTPLDDYALCAEVLRFAVSRLSPEEAKFEKNNQDPARSLIPESPHVSRSFFKDVMLRFHRQHSDSSWRDRYRKFAVKCGIKSYFEYYGRCVNEGTTPLVMTTVPLRDTELSVGAKALVGSNYNDDRVNIPLDEEISQTRSSTAGRLSEGAQKKRKVAAIATPVLGLVESDEEEAFFDPESQPEPNATTPAANVSTPAPKADEPTPKKPKVQASPEPGSEEVEEDEEDSQVGFEYLADPMMVYDLFEEEFFQESSDTMKSKLDTVYAEVKSQPLAFLMQKLKELHFKSGFVNHIIRSTGGVHARIKKYNDIWVSRLLNDPAFIEDGNSLLDMTGQVGIWTRLYDNELKKEKLLGVDSAEIKFQPKKEKTKRVAFLKSIGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY51</accession>
    <name>G3AY51_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HID1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_118420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY51"/>
    <dbReference type="STRING" id="590646.G3AY51"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306764_0_0_1"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="985" mass="111172" checksum="AEB7AD5E77ADEC62" modified="2011-11-16" version="1">MRTAEERLEFKNHFFKLGQGRIIDLTDKAYWSVFWEKPNGANDIFELLTPFDIQSLRDQNRSNFLSLIYVLCQKLIAFVDLKKPLPSSQVLNCVRFLTKLIPFLYELEEYKTLESKFFLSSCYEPLIFVDSTSHPPQKIDTSNILADKLLKSLIRLLFFKGFTITPSRANKDVEPTEMISYSLWEPGIGVNAKYQAPDLIVESNRSSVMKLILTLCGNAIYSFPSQVVANGSLFLTLLVSSLPRIEVLTLVCSLINVVCRSVRPSSNENMLQLNEANVRFTRFSYVTHCIQFLTLMIVYPLPPKQDLEPLSQLNILAHKPYNMARLYFGKLHKDQELLFLTSSLVNSLKSPIIGSGESESVFNLNLSRFGNSPPLWVMETMMLLWELFQCNASFKELSGPKFYSVICFMLVFYIKQYANNNRDQNIVRLASCFLLYLSHQKPFVEDLLIPSPEFMNSLPPSNSFNQSQLSTRDFLVVQLCAILSNYALSKQSHPSNSLLATTLIEILYNLVPLISSEPYPGTNDPTKKLNNINPRNGLSYSACTALTNLIVRFSNRDFLLRASFNPDLLALLIRSICIGALRDTQASRMLLFSILKGEKTYAQAWSTIYSFKNEYFNEDALMLKTVQDDNEAQSEINEKDDHESINSLATTPSNRSFTNLNIQEDDDPKSPPMMSQPQFSFYGNETMSASIEAKAIDRALRPSLPTGMTTKARGKQRKEASISKTWAGNDALRIIITVIIPHLKLTLSEVWAVDNAPGIDAFTLVQHIADADFAKVIEENSKQINYDFLPTSPLIPLKFSWSTISLGWYLSLLFSDIYNGIDSVEHATGGNYKIVKNLASTVLSFGKFFQGGDTTMNAIVETPETVAEVEKSITKVNHWSQTNIRLFKIKTEASLFDIFNSKLGVIPNQSMPGTPSLDRPSNLSRRLSDLRLQQIRSATPVSGMNTPTQEPEAYFPTRGNSVSSFHSLNTLNRSRTNTPRNSISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY73</accession>
    <name>G3AY73_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112651</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY73"/>
    <dbReference type="STRING" id="590646.G3AY73"/>
    <dbReference type="eggNOG" id="ENOG502S2AU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081626_0_0_1"/>
    <dbReference type="OrthoDB" id="2093493at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="196" mass="21583" checksum="3C0883D3AB8C8583" modified="2011-11-16" version="1">MSGGPVPVWKKYTSGSKGIWEKLRQLLVLVPNRSSGNPIVSMFRAQPPGDRITEARNYVDPITIPAGDIKGNAYHHRDYRRNYPQIYGFDQTKVSGLLKLGSVEKPRIAIGNKGNQELQVFNDPGAPVSLSVTLSSVDSSIVKGEVLGDVGEPIVAPSLNKFTWKITQEQENGMYTDQYPCRVFTDEKNSSARASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYK9</accession>
    <name>G3AYK9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_118715</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYK9"/>
    <dbReference type="STRING" id="590646.G3AYK9"/>
    <dbReference type="HOGENOM" id="CLU_2910224_0_0_1"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="62" mass="7232" checksum="8473C01258E33312" modified="2011-11-16" version="1" fragment="single">TDKSWLLSAFDQVDFYPVSEAEIDKFNEEICGGKRKPDIIESVFIHAKYLDWIQEHTNLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYY1</accession>
    <name>G3AYY1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_112834</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYY1"/>
    <dbReference type="STRING" id="590646.G3AYY1"/>
    <dbReference type="GeneID" id="18246697"/>
    <dbReference type="KEGG" id="cten:18246697"/>
    <dbReference type="eggNOG" id="KOG3484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140546_0_0_1"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000002">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="104" mass="12309" checksum="A66DC4B90B038EA0" modified="2011-11-16" version="1">MNSGKPRYLTDSERAKILEFQDSIHYSPRYSDDSHEYRHVMLPKGMLKLIPQDYFNPETGTLRILMEDEWRGLGITQSLGWMHYETHAPEPHILLFKRAINYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ16</accession>
    <name>G3AZ16_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112856</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ16"/>
    <dbReference type="STRING" id="590646.G3AZ16"/>
    <dbReference type="GeneID" id="18246707"/>
    <dbReference type="KEGG" id="cten:18246707"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034027_3_2_1"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000010">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="254" mass="29739" checksum="D94BCB456D70071E" modified="2011-11-16" version="1">MANGVEEEFYTDSSSDFTEYWIDLFLGIKGNEYFCDIDEEYIRDRFNLTGLNQEVNKLPTLIDIITDVIDLESQDEEQRETLEHNARILYGLIHARYILTSRGLNKMFEKYRKGDFGYCPRVNCQLHPLLPVGLNDQPRLASIKLYCAKCEDFYNPKSGRHSVIDGAYFGTSFPAMFFQNFPQAIPVHDRRCYTPKVFGFKLHDYSQLNRWRELQRNKLEKRLLKNGVDIYNKPGGFVMDAPVAKTDDDKKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ17</accession>
    <name>G3AZ17_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_118997</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ17"/>
    <dbReference type="STRING" id="590646.G3AZ17"/>
    <dbReference type="GeneID" id="18248671"/>
    <dbReference type="KEGG" id="cten:18248671"/>
    <dbReference type="eggNOG" id="KOG2713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_1_3_1"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="359" mass="39994" checksum="C1B1162072246CD9" modified="2011-11-16" version="1">MFTTATVTETKKFPSGSTVFSLIQPTGKIHLGNYLGAVSNWKDISQADEDPSTRYIFGTADLHALTSVKDQQVLKNARHEAIASLLATGISPERCIIYHQSSVPEHAQLSWVLTCLTSMGALNRMTQWKSKSKVDEMSSISDLETMGKTKAGVFTYPILQSADVLIYKSTHVPVGEDQAQHLELTRTIAQAFNSTYKTDFFPIPKSVLTPTKKILSLKNPSKKMSKSDADQNSCIYITETPDSIAKKIRKAATDSIQGKVYFDPENRPGVSNLINIVSGLSRKSIDETVKDLDWVKDHKQLKDHVTEMIVEEFKPKRHIFDDLMSDVAYLEQVTNKGREKAKAIAGPNMKEIERLIGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ99</accession>
    <name>G3AZ99_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_112905</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ99"/>
    <dbReference type="STRING" id="590646.G3AZ99"/>
    <dbReference type="GeneID" id="18246730"/>
    <dbReference type="KEGG" id="cten:18246730"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_1_0_1"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="362" mass="41379" checksum="0334A66169379688" modified="2011-11-16" version="1">MSESPLNTITKYNFPHYDNQPTSVWNRLPVSRRSAVFVLLFLGKLGELRVVLTKRSSKLRNFPGHISFPGGKSDNGLESEWHTARREMEEEIGLSANNEYLLKNFGFEIDHLNVMPSYLSRTFSAVRPCVGFMRFAADTSGADLIHNLKVNLNPGESSSVFSCPLQDFLYPISDRDSLECIEKQSFRMSWGGIPWMLRTYTFPQLVAGEASWLQEVQGLSESESESELNSDSAELQGEESQAQSEEVPQTSRGSRKLNREKWGRLGSRRHSETNEKIYDVWGLTANILHDLANVVYTNNATNSEFGQEDLIYSIWHHGNQMREKKRSPEESQLIESRSRPDDLGFGDILPRTEFLRLKQLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZG7</accession>
    <name>G3AZG7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112952</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZG7"/>
    <dbReference type="STRING" id="590646.G3AZG7"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_0_2_1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002019">
        <property type="entry name" value="DNA helicase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF317">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE ECM32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="280" mass="32411" checksum="5DBAEF7685C46C0C" modified="2011-11-16" version="1">MPGVDKFVFVGDQKQLSSFTQVSNLSLSLFERVLLNGTYQKPHMLDTQYRMHPSISAFSRHKFYNDLLKDGITAEQRTMNSIDRPVMFWDTQGKCSEERVRIRTREDNGYTYSNPGEISYIVDILQNLIYDKQVDKSTIGIITPYRGQRDLISKVLSENELINPTKEEIKVDVDRDDIYNDSKPVTIHTVSGIMIASIDAFQGREKDFIIFSCVRSNDTRKIGFLNDERRLNVAITRARYGLFLIGDHQTLDQDPLWHQYLDHLGSREFINRTDSVALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZJ3</accession>
    <name>G3AZJ3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HlyIII-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101464</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZJ3"/>
    <dbReference type="STRING" id="590646.G3AZJ3"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025943_0_1_1"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="66228" checksum="07A5D024F21E6D36" modified="2011-11-16" version="1">MSEITQGLRNRFHNSTKDSTEELLIEKLDIFLSSIESRLDQFERYFKFNNIEDLDEYYEEEKTKEVESGEETDESHQGHGRRTSVSSVSSFKSFANLDMIHQRLKLIKQSVLKSSISNLEYLYKTLDDSYSYMFNSSEPLISSDISFDNSKEILSQKIIDTLQYFDERLTHIDDMIQRKTNQVITDESIFNIFKFYNFNKALKLGQHNYLHYYQMPLGWRENRYIINGYRFSLSHWSMFKSIFHFNHNESMNIWTHIVGLGILFYLGLVHLPSTEVFSKNTFEDNLAIYFFLFCAVACLTCSTIWHTYSCFARISTRYNCACVDYTGITFLITSSVVSVEYAALFNYPKLFRTFMTISIVSGVGGLAFNWSPYFDKPECRSIRIGYFVGLAALGVGTVMSLCFYEGFVKSFQFIIPIFYKSFVWYWIGVCFYGGLIPERWRYDVIINEDECCQHEHSASDILAGNPEKSGEEEYKDIENDITNQILNEKPPSDHESEAMEHEKFKSIINKHFPEQPIQTNYKTDFFSLWWVDYAFSSHNIWHILVVFGVLGHYSCLLEMFSNISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZS4</accession>
    <name>G3AZS4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_119330</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZS4"/>
    <dbReference type="STRING" id="590646.G3AZS4"/>
    <dbReference type="eggNOG" id="KOG0264">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1610536_0_0_1"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="165" mass="19007" checksum="66302C51158E5435" modified="2011-11-16" version="1">MKFHQDIPTLLATGGRDNVINLYDLRNPTTPFRKLFGHDDSIAGLKWDSVCNPNKLTSWSLDKRVLIWDLDSLDEEFIYPTDVPENGKKNKNSRTTDPCLKFISGGHTNRINEVDIHPTLDGLHITCGDDSLLEIWKPKTIIPEEEEEEEEEDEKKNDMEVDQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B078</accession>
    <name>G3B078_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_97252</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B078"/>
    <dbReference type="STRING" id="590646.G3B078"/>
    <dbReference type="GeneID" id="18250671"/>
    <dbReference type="KEGG" id="cten:18250671"/>
    <dbReference type="eggNOG" id="ENOG502S4UD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150783_1_0_1"/>
    <dbReference type="OrthoDB" id="3063237at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="97" mass="11424" checksum="F593108889F25A0F" modified="2011-11-16" version="1">MSDNLYSHREGQNNQRFDELASTLRQFRNTVDDIQSNVQQENSMLNLLNDNFGRMMLSVKRTSGELRTVMNRNSSLTKTVGVILIFFFVVWMLYKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0M8</accession>
    <name>G3B0M8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113191</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0M8"/>
    <dbReference type="STRING" id="590646.G3B0M8"/>
    <dbReference type="GeneID" id="18246848"/>
    <dbReference type="KEGG" id="cten:18246848"/>
    <dbReference type="eggNOG" id="KOG2590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932400_0_0_1"/>
    <dbReference type="OrthoDB" id="4026735at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="299" mass="31517" checksum="B2F214CD47DB1552" modified="2011-11-16" version="1" fragment="single">MSSISYANIAANGSSSSTTSASNSNGNSNAGTTVTSPAPIPAEIESLAKSEGQVELPLEETSDAGAVEAPENDAAPKTKEKKLAPAPVPATSVWGTHAGAVSGSTSHVTNVDEYKWPTPEEQQANASAKSSNKNQKFIKPITNKWVPINAKVILPNARTQVTQQASNNGNKKNKKNNNTNNNNNKNNRNKKSAPAVNVGVNGGKPQQKRAESSDASARNSEKVNDRKSEDEEIKSLADDLNGSLTLGSPEVPSIPISTPDESVHQPPVNRTVESSSQESYSPGPQYYQNNGSFVPPNSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0R2</accession>
    <name>G3B0R2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113209</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0R2"/>
    <dbReference type="HOGENOM" id="CLU_3001929_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="57" mass="6395" checksum="7EB6285328355E98" modified="2011-11-16" version="1" fragment="single">AVRSYTGNSFSGSDFHCVRPNRKISILYLSSPVLRTSQDTILSAKVDVRLKKLRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0V1</accession>
    <name>G3B0V1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113581</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0V1"/>
    <dbReference type="HOGENOM" id="CLU_3068480_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="53" mass="5953" checksum="3387B38868F1A35B" modified="2011-11-16" version="1">MNVANETTSTFENRINQSALCGYVQEGICEGSECQVRRRLTSGWTPHSAHPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0W1</accession>
    <name>G3B0W1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113588</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685626.1">
        <property type="nucleotide sequence ID" value="XM_006685563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0W1"/>
    <dbReference type="STRING" id="590646.G3B0W1"/>
    <dbReference type="GeneID" id="18247034"/>
    <dbReference type="KEGG" id="cten:18247034"/>
    <dbReference type="HOGENOM" id="CLU_208687_0_0_1"/>
    <dbReference type="OrthoDB" id="4025483at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="60" mass="5933" checksum="8F432B298DD8EB5F" modified="2011-11-16" version="1">MPDDKANFAKNIAVSVAGSVGANKLADKAGLGQVGHIVSGVAGGIGANEAENKAEQEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B169</accession>
    <name>G3B169_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_134198</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B169"/>
    <dbReference type="STRING" id="590646.G3B169"/>
    <dbReference type="GeneID" id="18249777"/>
    <dbReference type="KEGG" id="cten:18249777"/>
    <dbReference type="HOGENOM" id="CLU_667303_0_0_1"/>
    <dbReference type="OrthoDB" id="4068596at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="412" mass="43731" checksum="BC6A73304B2B1A59" modified="2011-11-16" version="1">MSVVIPSSAAGWPHNGTATTIPAKPPSRKPARVSKPRKEKHSPQKFDAINYERNDEFKLDYELASSISLRVNQLIKRQVLMNSLINEDSRANIIRLIANSILSEHKEVIGFADPRHFNTWYSSSPGSTVNPNANLIPLSPLLNDSDAEYPASNPSPNPNSSALDSLTLPGISTNLMFVHGNNLHNGSGNTVNNSFVIPNQLSLSQIQNQGKQLPSFNSIQNSLPLSPTASAATLFGATSSLPNPNGIITVNTVNTNGTVNMNSASTPNTTYGGSSNSSLQSNYTSSTGTSSTSNTSYNNFNTWNPTLNPSNLLKSNPNKSSGHSHANSSNFTTIAMGYESTSGSSKGPVNSQSGISNNNNYLGALSTLLNVPGVSSPNSNSNIPGQNGLKSSPFIGNDLPLPFKLRTESDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3B179</accession>
    <name>G3B179_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_121058</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Vacuole membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B179"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_7_1_1"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="1059"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="17">
        <location>
            <begin position="1315"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="16">
        <location>
            <begin position="2069"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="18">
        <location>
            <begin position="2414"/>
            <end position="2446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV64899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="2446" mass="277884" checksum="95531A7886ECAD3B" modified="2011-11-16" version="1">MSVSQPQIVDGIELNQIFKGLRSNSEDERNRYAIELRNHLDSVARDLTLEHFNRYINVINKTIFELSNAPDNASKFGGIAAIDALIDFNSGIGEENATKTARFSHYLYPLTLSNDLAVMKQATKTLGKLAIPGGPLTADFVEYEAKKAIEWLQNENNQHDQRRHTAILMLNSLADNSSNLLYNLVGQILEQLWTELKDPKLDIRVDSAATLQRCLAIIYDRDVNARRFWVKHFFDVASKVLNDTPSTNGVDHSNGSNGDSNGYAMIPTPNGTQSFAAIHGALLVYRELLKYKNDQFIASRFEMLYENTIIYKYHNKAVIRQELTNIFPLVCSVNPEMFVEKYLHKILYYYLSQLKKLRKEYKEPACLEKSCIFRSIGSIALEVGNQMATYLDAILDNIREGLSYPTNSTYRASRKETEPAIFDCIGKLSISVGPALTKHLQRDILDMIFSNCSLSKHMQDVLQTLSTNIPVLTNVINTKLLNLLNLVLSGVTFQPPGSPYGTTKMNESLAKDYRLIMISRDTGMSINSILNNQEVYEQYECNILVQALQMLVYFKFEGYQLNEFVRYCTITYLQNPIPRVRQTAVVASCEIFINDPICEQVSVNALNAVNEVLDKVLTISITDPYPEIRLEGITCISNARCFDPQLSQPENLRLLFIALNDEVFSVRKIAITLLSRLSSINPAYIVPSLRKTLIQLLSRLEYSTASRKKEESATLLSLLIANSKDLTKPYVKPIVEGLLPKAKDPKSSVAASAIKCLGELAVVGGEDMKPFIPDLMPLIIDTFQDQSSSYKRDAALKALGQLASSSGYVIQPLLDYPQLLGMLVNILKSEASPTVRRETVRLLGILGALDPYKHREVEQSSKTISAEQNAPPIDVALLMQGMSPSNSEYYPTVAITNLMKILKDPSLKIHHSKVILAIRYIFQTLGLRCVSFLSQIIPGLINVMHTCEPAMTKFYFQQLGALILIVKQHIRPFLKDILGVAKEFFDLNDENNVAVIIINLIESISRALDGEFKMYLPEVLTLLLNVFDKDKSPERETTLQVLKCFVIFGGNIEEYVHIIIPSIVKMFESGSVPLRKAAIESIGRLSKTLLLNDMASRIVHPLIRVMKQDNEELKTATMNTMCYLLVSLGTEFTVFIPLIKSVMYENKITSPTFDQLVNKLVHGDPLPAQLSIYKDYEIHMSHFDVPSSDVSLKKLAFNQAALKSVWDPSQHRTREDWSEWIAKLSKELLRHSPSHAMRACAPLATDYYPLAKDLFNASFSSCWNDLYSQNQEELVESLCIALSSPNNPPEIHQILLNLAEFMEHDDKSLPIAITTLGQYAQRCHAYAKSLHYKELEFYEEPTTSTIEALISINNQLQQSDAAVGILKHAQMHHDLQLKETWFEKLQRWDDALRAYNERSKTEPDNMEITMGKMRCLHALGEWEQLSDLAQSKWSGTSSDTQRNISPLAAAAAWGLGQWDRMEEYIQVMKSESPDRAFFNAILSLHRNNFEDASNLILKARDLLVTEITALVSESYNRAYGVVTRVQMLAELEEIIKYKCLPQGSEKRAVMRKTWNTRLLGCQRNVDIWQRMLKVRALVIKPKQDMEMWIKFANLCRKSGRLNLAEKSLNSLLEEGSPENPSRAPPQVVYAQLKYMWAKGQQKEALRHLVDFTTRMSQDLGLNPNDLITQPLPSEGPGIPKHVEEYTKLLARCFLKQGEWQIALNSQWKSESSEIILGAYLLATHFDDKWYKAWHNWALANFEVISSFTAHNNNIAEIQPSAELSNEDDQNKEHPQNQQEIRATTIPMEAVQRHVVPSIKGFFHSIALSSSNSLQDTLRLLTLWFNFGGIPDAAQAINEGFNMVKIDTWLEVIPQLISRIHQPNPVVSRSLFGLLSDLGKAHPQALVYPLAVAVTSESINRKKAAMSIIDKMRIHSPLLVEQSDLVSNELIRIAVLWHEQWYEALEDASRLFFGDHNTEKMFEVLEPLHLMLQKGPETMRETSFVNAFGRELADAYEWILNYRKTKDITNLNQAWDIYYNVFRRIGKSLPSLTSLELQYVSPKLDEARDLELAVPGFSEAGKHITKIAKFEPTIPVISSKQRPRKIEIRGDDGKHYFFVLKGHEDNRQDNLVMQLFGLVNTLLSNDPECFKRHLDIQRFAAIPLSPKVGLLGWVPNSDTFHVLIREYRESRKILLNIEHRIMIQMAPDYEILTLLQKVEVFTGALDNTRGQDLYKVLWLKSKSSEAWLDRRTTYTRSLAVMSMVGYILGLGDRHPSNLMLDRITGKVVHIDFGDCFEAAILREKYPEKVPFRLTRMLNYAMEVSGIEGSFRITCEHVMRVLRDNKESLMAILEAFAYDPLINWGFDFPTKAVAEATGIKVNQVNVAELLRRGQIDDEEAARLNKQNELEIRNARAALVLKRITDKLTGNDIKRLKGLDVPTQVDKLIQQATSVENLCQHFIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1E5</accession>
    <name>G3B1E5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase 49 kDa subunit mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113697</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1E5"/>
    <dbReference type="STRING" id="590646.G3B1E5"/>
    <dbReference type="eggNOG" id="KOG2870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="202"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="472" mass="53562" checksum="D686D26980499914" modified="2011-11-16" version="1">MLRTRNLLRFGSSRPSRCLSTTPAKLHTISNDPKPFLNSMGKEYEKYTQDYGSFGKTTFSEVLDEIDMTWGKDDDPKKVAKQNSKIRHFTINFGPQHPAAHGVLRLILELHGEEIVRSDPHVGLLHRGTEKLIESKTYMQALPYFDRLDYVSMMTNELVFALAVEKLLNVDIPLRAKYIRTLFGEITRILNHCMSVLSHIMDVGGLTPFLWGFEEREKLMEFYERVSGARLHTAYFRPGGVSQDLPAGLLDDIYMWATQFGDRIDEVEELCTDNRIWKSRTQDVGVVTAEDALNYALSGVMLRGSGIPFDIRKSQPYDAYDLVDFDVAVGINGDCYDRYLIRMVEFRQSLRIIEQCINDMPEGPVKVEDFNISPPSRAMMKEDMEALIHHFLLFTKGYAVPQGETYTAIEAPKGEMAVYVVSDGSERPYRCKIRAPGFAHLGAFDHISRGNLLADAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Z1</accession>
    <name>G3B1Z1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_120205</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Z1"/>
    <dbReference type="STRING" id="590646.G3B1Z1"/>
    <dbReference type="GeneID" id="18248759"/>
    <dbReference type="KEGG" id="cten:18248759"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004312_6_0_1"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="12">
        <location>
            <begin position="74"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="458" mass="53134" checksum="50F8F92A86BE6330" modified="2011-11-16" version="1">MTKFKKRQSFDNNLIVTNTGTQMARASVDSVNTEVSRMRGSILVKRNLTLKKLQNKQKFYDDDKVLIGNKISEGHENFVMAYNMLTGIRVAVSRCSGVMKKISDSDFKSYTKLTFNTDGSEMTPSSKYDFKFKDYCPEVFRDLRSTFGLDQADYLISITGKYILSELGSPGKSGSFFYYSRDFRFIIKTIHHSEHKQLRRILKEYYSHVKSNPNTLISQIYGLHRLKMPLLNGVKRKVHFIVMNNLFPPHRDIHLKYDLKGSTWGRYTKAEDAETKPLKDLNWLENHEAIKFGPHKRKVFMDQLQKDVELLKRINVMDYSLLMGIHNTKNKTSGSITKTKLSIFDPKSHDMHDVIKTNPRYIEPTDLPTDVYPGRSKFIFYGHDGGIRSTNVNNEPESDIYYLGVIDFLTSYSLKKRLETFWRSLSHTRETVSSLPASEYGDRFLKFIKDGITKEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B201</accession>
    <name>G3B201_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_120218</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685377.1">
        <property type="nucleotide sequence ID" value="XM_006685314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B201"/>
    <dbReference type="STRING" id="590646.G3B201"/>
    <dbReference type="GeneID" id="18248761"/>
    <dbReference type="KEGG" id="cten:18248761"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="502" mass="56828" checksum="F95B569F3EA9893D" modified="2011-11-16" version="1">MSMFVGIYLLTTYIIFYVVRHLYQDYLAQRWGCEPISRLNTNFCYNFFGFGDVKRILMSLKGGYSLYEESNQLNKLGLSTYETMVLGQYAIVTANPENAKAMMASQVDEFSIGVRSALFKDVLGQGIFTVEGKQWKHSRETIRPSFGKSEISHVAQLEPHFKKFTDALDRCMGQTVDVQPLLSRLAWDASSELLFGGSIGSLDMVDGTLKNDGFDECFITLQKYNRFRFLLGKYCWLVNPPARKQAVSEIKKFTQFYVQKALSLSKQDLENKSTGESTFLYDLAKTSREPKFLQDEILSIMLAGRGTTSSLMTFAIFELSRNPEIWRKLSSIVHEQFGDGSNLDLITFESIKKCQYLKFCLNETLRLHPPVSTTVRQAKKNTVLPHGGGADGLQPIFVPKATNVVLRIFALHRMEKFYGPNATDFIPERWENIRPGWAFVPFLGGPRVCLGQQLALTEAGYIIIRLAQTYREFVNMDPQSPPPLSVGAVSKLKRGVLVQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2A3</accession>
    <name>G3B2A3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113407</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2A3"/>
    <dbReference type="STRING" id="590646.G3B2A3"/>
    <dbReference type="GeneID" id="18246945"/>
    <dbReference type="KEGG" id="cten:18246945"/>
    <dbReference type="eggNOG" id="KOG2255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_2_1_1"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="263" mass="29886" checksum="0056E9D66640FC43" modified="2011-11-16" version="1">MQILRYATRYILNNHLSRSSTRALSTIKPDDTKPPFLMVASIGNPEPDYSGSRHSVGHWVLEQLVQNHWKNFSRFQKHRNISRGPYSVSQDSVSSNVLLFKSNETYMNLQGEPIHANWSEVRRIQSRQFSPALVVVHDEISLPLGKIQIRKQGSSPRGHNGLRSIDKIMGQNYTKIAVGVGKPPNKYVADFVLAKFKRPEVEVLEYDVMPQIVQVLEQMTKGEHIFEVSKAPEKRQRQPRPRQNTKKDSISEVVESAASTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2G6</accession>
    <name>G3B2G6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113460</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685476.1">
        <property type="nucleotide sequence ID" value="XM_006685413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2G6"/>
    <dbReference type="STRING" id="590646.G3B2G6"/>
    <dbReference type="GeneID" id="18246968"/>
    <dbReference type="KEGG" id="cten:18246968"/>
    <dbReference type="eggNOG" id="ENOG502QRJ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1128958_0_0_1"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF3">
        <property type="entry name" value="ABR032WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="255" mass="28533" checksum="0F3F63378028EE62" modified="2011-11-16" version="1">MPDIAAPTANSKVPTSKDAAHPSASEIAPSAPKKKKLVRKQKEASPLKYKLWLGGHAVAIAFGSISFIFQLLWLPNKWYINSIAYRLSLLGSIVALLATLSHKYGLHYLPPSSTLMASQNFQFIVLGLVWLFTFKSVLKILPFFLIAILQLGSHKNISAVTEHSPFVASVIAYNELVLIVYLLLRTLLFRGTSGFQLVLFLLFYWLRILYNPETSNLFKAIIGRADGKISGVKNEKVAHYWEKTKLILEQKTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2K9</accession>
    <name>G3B2K9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_97558</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2K9"/>
    <dbReference type="STRING" id="590646.G3B2K9"/>
    <dbReference type="GeneID" id="18250693"/>
    <dbReference type="KEGG" id="cten:18250693"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037134_0_0_1"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="224"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="492" mass="54949" checksum="812A349D5FC8553B" modified="2011-11-16" version="1">MTEFLNYTVDLYLKDGSVSSGQIVSVDGTKIQLSDVSESKAPGQKLPTLEILNSSVNDLKVTKLPPDFVKNLKKSKAKKEKVTKKEKKDESDVSGKNSDSEIKMTEDFDFAANLAMFDKKSVFENFQKKDTIKPEQRLVGHNKVENFRKDYEKFRNDEMVLDSTRTDDWDSIGISDRKETLRNASVTGRLTPVHDVTGGSSNKNYTLTNVSTGNSVPVCSPIQLLDIERISGEAFALTPEVMAEIFSTNLSQYITQHILGGSGRLNPNNHNLPPLVVLLIGSERCSIRALAVGRHLTNHGVRVLAFLVNHEMVDASYLKQKSSFEQAGGKILSTSVPELLHVLNHQLDTPVELIIDALQGYDDHLEDIFFEQKEQQLIKQLITWCNEPRQRGKVMSFDIPSGIDGGSGTITDADLVISSHWCVSMGLPVAGILHAYRNEILRVDAESETLHLLVDIGIPNKVYSRKPNLRRFDRVWYGAESVVKLQPVEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2V6</accession>
    <name>G3B2V6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_113551</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2V6"/>
    <dbReference type="STRING" id="590646.G3B2V6"/>
    <dbReference type="GeneID" id="18247016"/>
    <dbReference type="KEGG" id="cten:18247016"/>
    <dbReference type="eggNOG" id="KOG3405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112527_0_2_1"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="154" mass="17420" checksum="BFE5F2E9E805EA58" modified="2011-11-16" version="1">MSDIEENAYNDAPENYDDFDQADHFSENEFEDPEPETNGDVDMKTEDGRTIINGGIGPDESKPRAKTTAELAIPKHQRTTTPYMTKYERARVLGTRALQISLNAPVLVDIEGETDPLQIAMKELSQRKIPLVIRRYLPDGSYEDWGCDELIIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B338</accession>
    <name>G3B338_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_114103</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B338"/>
    <dbReference type="STRING" id="590646.G3B338"/>
    <dbReference type="GeneID" id="18247265"/>
    <dbReference type="KEGG" id="cten:18247265"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="238" mass="26832" checksum="8B5D89E1885FA3CB" modified="2011-11-16" version="1">MPDKYSVILPTYNEKKNLPILVYLLSKSFEAANIDWEVIIVDDNSPDGTQLIAAKLVDLFGKNHIQLRPRPGKLGLGTAYVHGLQFVTGNFVIIMDADFSHHPEAIPEFIQKQKEDDFDIVTGTRYAGDGGVYGWDLKRKLVSRGANFLADFFLRPRISDLTGSFRLYKKDVLEKVIQETKSKGYVFQMEMIVRARTLGYNIAEVPISFVDRLYGDSKLGGSEIVGYLKGVWALFTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B374</accession>
    <name>G3B374_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114135</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B374"/>
    <dbReference type="STRING" id="590646.G3B374"/>
    <dbReference type="GeneID" id="18247278"/>
    <dbReference type="KEGG" id="cten:18247278"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_2_1_1"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="60"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="267"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="418" mass="44720" checksum="61EB5004D517F8A2" modified="2011-11-16" version="1">MPSLSDSTPLVNLRGSRAQSLQSSIITPFVVVLKSSPVNYLLVFVPLGILAGNLGWSSNAIFWINFFAIVPLASILAFATEELAEHTGESIGGLLNATLGNAVELIVSIIALKDNQIRIVQASMLGSLLSNMLLVLGMCFIAGGITRVQQTFNQTVAQTMSSLMALATSGLMIPAAFHATLPAPDKQHEFPAPGSSDELIISLSRGVSVILLLLYVMYLVFQLKTHRSLFEDQGGVHDADDGIITTAMPPDSSATKPADRRLSISESLVVLLLSTVLVSICADFLVGSIDDIVETTGLSKTFIGLIVIPIVGNAAEHVTAIIVAMKDKMDLAIGVALGSSLQIAIFVTPSMVLLGWVFDVPMSLYFSTFETIILFVSMFISNLVILDGESNWLEGAMLVSTYLIVALAFFYYPDTQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B381</accession>
    <name>G3B381_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114138</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CBP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B381"/>
    <dbReference type="STRING" id="590646.G3B381"/>
    <dbReference type="GeneID" id="18247281"/>
    <dbReference type="KEGG" id="cten:18247281"/>
    <dbReference type="eggNOG" id="ENOG502S2G8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147520_0_0_1"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="141" mass="16716" checksum="DF2D5F85CED2FC02" modified="2011-11-16" version="1">MDVNPPRWKKVLRAGIYGNAVILLGVVLFKYTTPTEEQLISRFSPEIRADYEKNRSFRQQEQQELMKIVRETSQSSDPVWKTGKIKSPFEKDTRGLDPKLVDVKVFEKQEALAYQREQIDKSTEELAETEKLLAKKRWWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3I6</accession>
    <name>G3B3I6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maintenance of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_105575</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3I6"/>
    <dbReference type="STRING" id="590646.G3B3I6"/>
    <dbReference type="eggNOG" id="ENOG502QXZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024520_0_0_1"/>
    <dbReference type="OrthoDB" id="4064064at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="68300" checksum="C319395E97296E14" modified="2011-11-16" version="1">MLPSQFDPSSLSAVDGNGFDFDTVLSLDSYRSSGRESTAVESVQSHSQDYDEADLKKARELAGMLLDSKRTYLQEHKLLDIRGMEDAFNATDNSKMMTIPKATYLRAERVKATLSLKYIVIDRTYSHQDTIKFPGVDGVYNPLQIIRNRKLRAKYREPPQSITFKTMPLASTAFSSKNIAGKQRPWRLMWAVELNELVGDQAWRMGHIYELKKRNGDLWFPKSSGLSIGSGKVAKARKHEGRLKMKNRLHDKLFVDDDTESGDTKSMVSDQSETSGKSRRSSNLSPLTELKTGRRDRLKTKVRKTLRGSHESGSGSEVEESIQGDESVEIKEEINPYVASKDDLNISSRPFQTELEAPFSSLSNIKFKPTEGKRNETDVVEITEPDLEQPVSLKPQIESLDIQFKKISNNQRFFRNSTIVKLHFLANIYPQLFESACSRIDELTNTTIPRLNQLMVDINDDTIPTYDLQCSTILNEIKSLTLIINDDYSIKIDNLLTSSDRLLAEINTSLSLELRKVDEKLDRLNNSLFGNNFVGKLDLHQNQKISMNESGNYRIVYMLLENFIVIVLRVIWIVANIYKFVLFWFKLVWKIIKFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3S2</accession>
    <name>G3B3S2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_130139</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686031.1">
        <property type="nucleotide sequence ID" value="XM_006685968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3S2"/>
    <dbReference type="STRING" id="590646.G3B3S2"/>
    <dbReference type="GeneID" id="18249425"/>
    <dbReference type="KEGG" id="cten:18249425"/>
    <dbReference type="eggNOG" id="ENOG502QSJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045155_1_0_1"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42980" checksum="70949F0871941B44" modified="2011-11-16" version="1">MESPLTEDVLNGSPSLKIPSETINKEIAEFLDSLESQPKFNPNIKFDPNEHILYKDEDYDTFRKLTLQDLGIHKTHVPRVSDLAVTDPFPLFTKEACDMMKWESFQLKCLDKYGRLPKLARGFTSLDFQICGYINHAPFTKAAWTHPRTQEILNNIAGINLKIMFDYEIAHINASLINKDFPVGQKMGEEADMATIYDWHYDSNSFVIVLMLSTNDDMIGGKTGLIDGNERVISISEPKVGYACLLQGRVVRHVATKPVTNHERISSVVGYIPESVEITDTTVLTSFKPSVLPRSIHDEYYPAWCEYRFSRLEEMLKHKKEQLKRKEGHFDQKDVIAFCKQLEDYVLKTYNEFELYDNPPYPPKIYSTPYNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3U7</accession>
    <name>G3B3U7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113772</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686052.1">
        <property type="nucleotide sequence ID" value="XM_006685989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3U7"/>
    <dbReference type="GeneID" id="18247115"/>
    <dbReference type="KEGG" id="cten:18247115"/>
    <dbReference type="eggNOG" id="ENOG502QZ63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40557" checksum="05386073B98060C2" modified="2011-11-16" version="1">MAPSVDVQQMIVPKLPGETLLQTAKVPKEVFSNMEASFTSQTYGDWRDDLINDGFAVVKGALTKEKAKVYQNEAFDWITSFGTELDIKNPETWINKNIPVQSKINTFTGYRVPHEKFMWDIRQEDGVINPFAKIYGTDKLLVSFDSLNISFPGRKDKPTRGKWQHVDQSPLKDGLQCVQGVLALSNHGPEDGGLVVYRGSHKLFREFFDTQIDKSTWDPVDRYIFTDEQLQWFIDRGCEEIKTCCEPGDLILWDSRTIHWGMEPKQTSSEIRTVVYASYSPYFFATDETLDEKKKCFETWSATTHWPHDNIIRRPPHTLLEDGTRDPRDRDEPRVKPILTEKLLKLAGVVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B481</accession>
    <name>G3B481_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_113946</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573</strain>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686233.1">
        <property type="nucleotide sequence ID" value="XM_006686170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B481"/>
    <dbReference type="STRING" id="590646.G3B481"/>
    <dbReference type="GeneID" id="18247194"/>
    <dbReference type="KEGG" id="cten:18247194"/>
    <dbReference type="eggNOG" id="ENOG502S7CC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108081_1_1_1"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV63918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="106" mass="12160" checksum="1D29A1D882DF33B5" modified="2011-11-16" version="1">MSKILPFTEANTQRISSLFRQSLRTAFDHSMKFDIYRQQTISIRKQFDANKHISNPQELEAAIASTKAKLAEWAHPDPYVPPCRPGGTKYQRNIPPPNEHVVPGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4E6</accession>
    <name>G3B4E6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113848</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686117.1">
        <property type="nucleotide sequence ID" value="XM_006686054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4E6"/>
    <dbReference type="GeneID" id="18247144"/>
    <dbReference type="KEGG" id="cten:18247144"/>
    <dbReference type="eggNOG" id="ENOG502RXHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103810_0_0_1"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="182" mass="20460" checksum="EDEE60747BF4344C" modified="2011-11-16" version="1">MAIFRSKSGKTVEGYNPHERDYKMHSANVHDPVLSAVNEAQPFEQAADRIERRPSYLSQDSANLKDIFGQPINHGDMSNPTRSRNERPLDTIRAFEYAITGDVSYRDQLESSRLGWGFHEDFPHYDAVGGVGGSSGDLPGNDYGRPTINFGEQPMYSAQNYSASSLKNEQKKKKRGLFGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4F6</accession>
    <name>G3B4F6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_104937</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686127.1">
        <property type="nucleotide sequence ID" value="XM_006686064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4F6"/>
    <dbReference type="GeneID" id="18245762"/>
    <dbReference type="KEGG" id="cten:18245762"/>
    <dbReference type="eggNOG" id="KOG4781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052827_2_1_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="194" mass="22058" checksum="2083B69F4AAE7767" modified="2011-11-16" version="1">MVGETSKYEEHIHSLAVYQELLEQHKAFNLSRLIEENLRPNLTGDTLIGDDKINYRGNGIFFIDDAFLQEYDDIDEVKDGESNFLVTFFHLGSKLSGHNGIVHGGLLATLLDELTCRLAFQNFHSKKGVTANLNINYKKPCFVNSVVMIKCELSRKSGRKCWVKGSVFSVKDSELELLTECECLVIEPRWVKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4I1</accession>
    <name>G3B4I1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH dehydrogenase, alpha subcomplex, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_105022</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686150.1">
        <property type="nucleotide sequence ID" value="XM_006686087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4I1"/>
    <dbReference type="STRING" id="590646.G3B4I1"/>
    <dbReference type="GeneID" id="18245771"/>
    <dbReference type="KEGG" id="cten:18245771"/>
    <dbReference type="eggNOG" id="KOG3446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110897_2_0_1"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="92" mass="10372" checksum="BEBA371520C514C7" modified="2011-11-16" version="1">MSKFILPSTLRELRFHLSQTGEASVPLRKFLTTNYATLKTQSKNELPILIREAYGIPPSITARFEKGKEIKNNLEGLDEKAVAEALKTLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4M2</accession>
    <name>G3B4M2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114014</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4M2"/>
    <dbReference type="HOGENOM" id="CLU_3106160_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="51" mass="5982" checksum="6B81A99C2FDD7255" modified="2011-11-16" version="1">MHPPYETYHEAVRFCAVCWGWPRSSPESTWESLPSTAGEEWRWHSACTRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4M3</accession>
    <name>G3B4M3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_93487</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686295.1">
        <property type="nucleotide sequence ID" value="XM_006686232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4M3"/>
    <dbReference type="STRING" id="590646.G3B4M3"/>
    <dbReference type="GeneID" id="18250295"/>
    <dbReference type="KEGG" id="cten:18250295"/>
    <dbReference type="eggNOG" id="ENOG502QPU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009024_0_1_1"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000174">
        <property type="entry name" value="YIR007W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="4">
        <location>
            <begin position="126"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="798"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="923" mass="105645" checksum="7B242B8523FA9A15" modified="2011-11-16" version="1">MKGLYYFKEAQDAINNRISLYNTTSKVSLSGVRSLRHSYPDSEPILEAPATTKNSNSILECERLSTNEKGYLVDHHGRLITLKGINLDSAAKLPATPNMPTYKGDATDTDNVFFDGDNVSFVGRPFSLDEAESHFLRIKSWGYNTIRYIITWEALEHKGPGIYDEEFIDYTTKILEVIHSVGGLYVFIDVHQDVWSRFSGGSGAPMWTLYAAGLQPKRFSQTEAAILHNEPRFHPDDDTDTFPKMIWPTNYRRLASLVMFTMFFSGKNYFPQFKINGQNVQAYLQGCFFKSIKHFWMRVSKSNREMIEDGTLFGFETVNEPNCGLMGNTHLGEIPASQQLRVGTTPTVYQCFKLGMGLPCEVDVYRISLAGPQKYGTQCVDPNGQRAWLTIEEAHAIDARYGWERSPEWIIGECVFQQIGVWSYNEVDFKSLPSMSIEEKMQQNAICELQKPNFFNQFAAKHNFKMYSGVKPTKIDMEFFINNNFVDFVAKFKKTIRSITPDVFFMIQPPVLEIPPNLKTDPRGIVDKKTIYCPHYYDGMSLMFKTWNPRYNVDTLGIMRGRYLNPVLGIVFGERAIRNCMKKQFNEMKKECEDYLGSIPILMSETGMPFDMDDKRAYTNGRYSSQTLALDALSYALEGSAMSHTYWCYNSTNCHKWGDRWNNEDFSFWSAEDRNLSFTSQTSLGDILTSSVSTTASLLKNTRARRINSKVHTLKHKIKGSSEKEEITQIEEIEDDKGSIEAEEFEVSKQNIDDDEDDLRSIQDASLIFWTADNVKYRHSKKCYPSPDGVRAAGAIIRPYVVACCGDLIATEFDMRTVRFSLTVSIQKGDTGSCPTVIYVPKWHYPKLNYHDIYLSSGVVRYNKELEYLEWYHYENEDNSEMSTLVDDTVPKEETIIIKNNSGTLDDINPKDDSQKQGNCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4U7</accession>
    <name>G3B4U7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_93380</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686189.1">
        <property type="nucleotide sequence ID" value="XM_006686126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4U7"/>
    <dbReference type="GeneID" id="18250285"/>
    <dbReference type="KEGG" id="cten:18250285"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_1_1"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="74"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="641" mass="70541" checksum="0102A2BE928DFFD4" modified="2011-11-16" version="1">MSFSGQESKNALNGDEVENDTTSSKELEQVVSVPIPANMPISGTLANSTSKSMGVRKAEVLNDQYQSYVWRVILFVTVLITAYAYAVEMTVKGTIETYAVASFNQHALKSTVGVVQAVAAAAAQPTYARLSDRFGRLELIIVALVLYVIGSIVQFTSKNVDALSAGTVLYAIGIQGIIVLLQIVLADFSTLNWRLACSFIPALPFIINTWVSGDIVSSLYPAHSWQYGYGIWTFVFPLCCVPLVACFAHMRWLASKTPEWKALKEEGKLINKWKSWSDNIVIDVFWEVDVIGILLIICVFGFILVPFTIAGGVNDTWKKASTIVPLVIGVVLIPVLAFHEMRFAKFPLLPIQLMKDRGVWSAIIVAVFINMLWYLPNEYIYTVLVVGMNASIKAATRISSLYSFVSVIVGPLLGLLVTRVRRLKGFIIFGVLCWVGSFAILYTKRGDPDASQSQLNGVIGGLCLMGFGAGFFTYSTQVSISTCTNHEYMAVVISIYLASYNIGSALGSSISGATWTNTMYKNLAKEFEAIGFTNVTAAAAYGDPFTFAINYTWGTPERAAMVRAMAKTQKILCLIALVLSFVLLLDVFFLRDHRLDTVQSLELDHSKEEGIKSDDGGVIVNNYDDDFLLNRIKSLFKRGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B520</accession>
    <name>G3B520_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_93887</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686908.1">
        <property type="nucleotide sequence ID" value="XM_006686845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B520"/>
    <dbReference type="GeneID" id="18250337"/>
    <dbReference type="KEGG" id="cten:18250337"/>
    <dbReference type="eggNOG" id="ENOG502SC1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134520_0_0_1"/>
    <dbReference type="OrthoDB" id="4037694at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="131" mass="14527" checksum="8B97300F5EDDC1F7" modified="2011-11-16" version="1">MGGRINGFLAGALFTSAFVYYTGEYIKKDSQFVSRQLRISETIINEGIIQGKQLTSPIAPAAPRGTTTGNAGKVESAKDIWNQEIINAANWLYSINYYKGLENLDYWANKLSGKLTDAVSNKLLDESREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B527</accession>
    <name>G3B527_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_130646</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B527"/>
    <dbReference type="STRING" id="590646.G3B527"/>
    <dbReference type="eggNOG" id="ENOG502S0EG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035341_0_0_1"/>
    <dbReference type="OrthoDB" id="2507562at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="446" mass="49609" checksum="125C40FE83B3D912" modified="2011-11-16" version="1">MAPDRLPRATLEQKIQILDFYHQSNRPQSETVDRYKNQLSISTSSFSEWLKNEEDLRARLSHADSAFTKQSRRKVKFKYEKINRAMDLLVQQKLERGEPINEPILREHWSIYAHQFGVEDPKRLVGFSHGWLSQFKKRHGLNKKRMGGGPGDGDGNKSGSADGSPDSANATNSANGEVYDSAFGTDPSSTTNAGDDHDNGSADFSGATTAATSYDLMNPHPPSASNSNQFRSSHHHPQQSQQQPGLGYGNHMNFSNYQMYQQQSPSVQPNGTALPLEYDFRTQYPKDPQPGHVKPSRSQPPHPQLHQPHQVGAGKSSTGGSGAAGRVTSRSEVDFASNMSGADIERFIYMFADRYFHENASNYPQTMKVFQEFKTTFLNERIQQARSSTQSSQIVHSQGGRPSPSQTSAIDEFFFRNGGLPQPQSAGHDQEDGALMNSNGVNKWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5D0</accession>
    <name>G3B5D0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_93960</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5D0"/>
    <dbReference type="STRING" id="590646.G3B5D0"/>
    <dbReference type="GeneID" id="18250344"/>
    <dbReference type="KEGG" id="cten:18250344"/>
    <dbReference type="eggNOG" id="ENOG502QU87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001720_0_0_1"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="309"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="6">
        <location>
            <begin position="751"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1186" mass="134977" checksum="C80C9F7C6DA5D9A3" modified="2011-11-16" version="1">MPPMNSETASANNLPMDSLAHEGTSFRLISVTFKEAALDSPSFRASMNHLHGQLHNISSWASVLLQEAERLPKRVEEIKATMSSFSEYLLPSFADDGILDQETTVPLLKSVSHGHEVLLKTFFNLMSVDPQPVRELVSKVHTLMAKYKSQKHQFDSIQERYDQYFAVYMSASKFKQEEMAIEDSQQLFRTRKAYLHASLDLAVLLDEISTELDTHFIDIGNKIWSQAVTNEGVFGFSEVFRTTTLKIERTKSWANAYSRATKLFIQDIQAARKQIEESTIELFDPSTRPEDYDASLISQYTLNQIDEPSFEKHGYLMMKTWTKNSLKPIWVKRWAFISGGVFGMLILSPSKTFVQETDKIGVVLMNIRYAAQEDRRFCFEVRTSDQVIVLQAESLIDLKSWLKVFENEKSRVSLEDKDSTVFIVASSRFPPLITEFASTMDTVVDKQMLKTKIKNDDGRTVSSNTLSTKIKPHEKYFQKYLYYQIPSFKPPLVTSNTKTAILANSIASSAPVPSALTANLWGSVNWGVYYLYNGMAYQAETQKYPAGPSLFRAFDFNTKSSIRNNRSESYPDFLVSQDIEMKSLFESEVAPDEYCLVSFNCLWSPNANQELCSRMFITDRSVFLCNQVSGFRSLLASKIGGLVAVELRVREDHEELTVHLLNDSVVVKIYLEDGQLIYRYLQFLISNKESETPKTFNETVIGLVEISKAYQQEKSMLSLSHAPSVDDSLRTLQLKEKPASSDNLRLDYSNEYSVHYEKEYPVSAKAMCHIMLGDDSHFFLQTSALSASAVLKGPWTRLSDGKLINTFDYRFPRVFQGSGKFMGVLTIEKMVENVYYNITLEKKYFYFYGAKMSAQVRFVINASNSSNCIVHTYSAIQFFGVSPLNLPLKPALRRFQISETNKQHQWLKRVIKTLGDKGQVGKAIYLYGSISVADVQQNMEAPVCSIDVRSVVYLLVVKPLIEFIVSMKQKWLQVLAFIFGYAKEITGQRLLLAIIAVSGLLNLFLISKTSISYWTAQQAHNKALKIFNSQPIMLERAVYLKDIQELTFQDSSIGAGESQSLESFNKASFIRNVGSYVDLEQEYIDADIRESAMGLKRSFEEIGVKRHKVLMELRILNDMEKEVANAEYRNWLVSELRKCERFKKTAAANALSDLGAENVSFVEEGMKSIDEYCRGCLEDYKGLHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5E2</accession>
    <name>G3B5E2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_106277</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5E2"/>
    <dbReference type="STRING" id="590646.G3B5E2"/>
    <dbReference type="GeneID" id="18245874"/>
    <dbReference type="KEGG" id="cten:18245874"/>
    <dbReference type="eggNOG" id="ENOG502R8YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032145_0_0_1"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="494" mass="57054" checksum="74D73C396136429E" modified="2011-11-16" version="1" fragment="single">MLSTSVATTQNISHTPTASQIASSYDNQNPFHEHLQNVADNVSNSNDKTTKSPVPFLDRLVEDGDIDKSQIIQLLVLGQPKNITQYSEHIYKLLSILYEYEHITGDEYEKLNGKAINLFDGLPMYQNLNNPLASKLYLIVEKNFDMLIKISVDAHNLNLSTRAVRFLTEVISSLNYWEIYNLLTWKPAIYHFLCIIQFNMNECYLRFIKDYSSYNFRQQYVSFNRDNVGKRSRRITDGLDDEDEDEDEDEDMYDDNTSTNEDNENYSSGSNTPLDGKHMMIQHSGLNSQLLNADGEPVDMDGDTFINSDLKSLAPKDRKRITIEPKLARKIIKRANTRISTKSSNYDPDVVHECQLPSADEHGKMCLRRFSRKYELIRHQETVHSKKKKLFKCFVCVKQNPSIGPRIFTRHDTLAKHIRVNHKISGKEAKAEVAFSKKHAEVVEEGDITVHVGRRKTKVDFELRAHMEKKRINKDGEYYEADYSMDGDMDDSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Q5</accession>
    <name>G3B5Q5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114577</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Q5"/>
    <dbReference type="STRING" id="590646.G3B5Q5"/>
    <dbReference type="GeneID" id="18247487"/>
    <dbReference type="KEGG" id="cten:18247487"/>
    <dbReference type="eggNOG" id="ENOG502S7CA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729576_0_0_1"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01119">
        <property type="entry name" value="COPPER_FIST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="379" mass="41260" checksum="7A9F9C02E7333F1F" modified="2011-11-16" version="1">MVLVHGIKYACERCIRGHRVTSCTHTDQPLTMIKPKGRPASQCQHCREQRKLKSLHISCSCDKKGGTHASNCLKNPAGCTCYHTHKSKIAEKSKKKDKGKDSENAISSTTSIMEGKITIDDEFIKSNSDLFEFLNSNQLDLGDYNNMKSSVRDSDGGNHKNFDKSMDFPLFPLIGTQSFDNENMPLSSLPSDQPTSSMGNSNQTSSVNNSSSHSSNQSTSSPTPAQSSMSINNNDGYIINNAAASEMGSTNGNGITTTHSNSNPNFQVVSSIARSHSFKNRPSSVLSVNSGSSFTDSKFDAYPPSGNVSNINSSSNLNIAPHSPQNADVNVNNNHNSNVIMNPVPTSKNFPFGNILESNELYISDEDLEHFLNDYDNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5R6</accession>
    <name>G3B5R6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_106260</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5R6"/>
    <dbReference type="STRING" id="590646.G3B5R6"/>
    <dbReference type="GeneID" id="18245872"/>
    <dbReference type="KEGG" id="cten:18245872"/>
    <dbReference type="eggNOG" id="ENOG502SUS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556813_0_0_1"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54039" checksum="536581D72C4351DF" modified="2011-11-16" version="1">MENISINHVDLQTKIIAQDILDKSSSQPIYLSSVEVVGGETFSNVFFKKLLSPLLETSDYTFGKLVSNVEASYNKLKDTEVFTDIGVSFSTDFTSGIPSNVKNYNSKTDKPIPTKVKFDVKSINLNIGEYFLNLDNDTPLNVNLHYLNNNFNSNAELINVGVDYNPYKPNQHLVTNGKLISNLTNPRFKFVIDLFNTNQNNKIWQKSSENSLGGVIGLQYNNTSRNLHFLTGLSILKRKLHDMDDSTIDDVKLFAGDNIKSSIINELSYSNLSFLNSATNNFPVNGFNFLLSNELSSNQQLNDPSSDSGYFCKSSFTSNIFKTFANNYLTLKISNSFGSIYNPLLEELSPVHVSDRFYLGGSKSFKGYSKNSINANGGNQFYKLDSSLFLKLPHFLYSPKHNQNNEANPLRLYVNGIAGNVSDNLLDDSSLSTSVGFGLKYFNNWAHFDLGYYLSKKINNVDQLGVKDGLQFSLSVGGSNRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5T3</accession>
    <name>G3B5T3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_94063</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5T3"/>
    <dbReference type="STRING" id="590646.G3B5T3"/>
    <dbReference type="GeneID" id="18250355"/>
    <dbReference type="KEGG" id="cten:18250355"/>
    <dbReference type="eggNOG" id="KOG3745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003875_1_1_1"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="2">
        <location>
            <begin position="136"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="91068" checksum="57AD486538EF55C8" modified="2011-11-16" version="1">MAQVIWNSDIDVYNPDVIAIPVAQGIVKYLAIADLLVFSRVSKNAYKTVNDPQIWISMLKEIGLWRKEGTNETKDINSLKLNALNCMDQACSTPARAKKIVLGIHKSLEKFYVDLLSNKSYDKLKIFQEFQSPEEQCKILNNLMQYSHLDKNDETRFTIQEKLGSLFEIFENALLRELDIHFDLEDYSTMKRFVNVIIELNNHQTLIDFFMQKSIFDNHDNVFGLLEYFNPEEFFTNKTVGEELEYELNSSRFNELMNQLITMFNYESRTIDLIFPKTVPMMYKVSEELILNQLADIFNRLIEASKGKKLYLSIVPYLYDKIVNSFISKLNQSENLGGNYLNLIQELFDMSFEQVVTEYSREEIVSFKGLSNQKIQEWKESIERREVETSQNILRNVKTETKNDFLTSFRKAFAVGSNRNTEDEQVENESYSEIQAKEKILTENMKSINKIFSLKLAMQILNDGKNCLIRMLHFKDFTIVSVRQSLMTSVQEIFISVLESIGNDHLKPGFDKALVYLRTYKPVEDDTHAPEPIKPLVLFSDLVNVADLIMQMVEIFYKEELINRRIIKNENSILNPSLQRKKKLEEMVDNYVADGLNIGIDVLIDEIEQAYSPVLQNNSYCPHNETSVEVQDSTPAARRVVSVLDGNFDLLVGCADKSVIDVFQQELAERFFQVIVKVMKSATISNTGAVTLISDLNIYYECILNHIKTNKRFILPLFESLKKVGSIYLIGGNDSKAIGKLVSDLSKFNGIFGQEEIYEFVQRREDWPLIKKDVEKIMYGLSLGDCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5U8</accession>
    <name>G3B5U8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_106160</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5U8"/>
    <dbReference type="eggNOG" id="ENOG502SBQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188578_1_1_1"/>
    <dbReference type="OrthoDB" id="4067208at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="53" mass="6257" checksum="3C1D1066218D36EC" modified="2011-11-16" version="1" fragment="single">IMYKFLVSRWVDPLIGVGIGVCAYYLHETRSHTPEGKRIKDIIYRRFISSKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Z9</accession>
    <name>G3B5Z9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_105835</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Preautophagosomal structure membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Z9"/>
    <dbReference type="STRING" id="590646.G3B5Z9"/>
    <dbReference type="GeneID" id="18245840"/>
    <dbReference type="KEGG" id="cten:18245840"/>
    <dbReference type="eggNOG" id="KOG3439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106795_3_1_1"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="94" mass="10585" checksum="34EF52B8DE226FB5" modified="2011-11-16" version="1">MFLDSLVHDEKITIRFKAVGSTPSVNPKIFKISSSSSVSVLIKFLCNRLKSKTIYVYISNSFQPNPDENLGQLYQMFGVNNELIINYCNSIAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B689</accession>
    <name>G3B689_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Protein transport protein SEC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_94166</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B689"/>
    <dbReference type="STRING" id="590646.G3B689"/>
    <dbReference type="GeneID" id="18250368"/>
    <dbReference type="KEGG" id="cten:18250368"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="13">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="14">
        <location>
            <begin position="305"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="16">
        <location>
            <begin position="550"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="15">
        <location>
            <begin position="643"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV63414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="933" mass="102482" checksum="D9E6C821B81A04D1" modified="2011-11-16" version="1">MSKRRAYPQPQYASTPQAPVAPLQPGVPAYGVPPVIPGVQSPPVQQPGVNANYYQPDQLASQFQGMNVGDAQAPAAQAPAVNGQYQYGNYQQPGANQPYQPQTGGYNAPGAAYGAPATGFSAGTAYGASTSTPSLPLNELYSTDLIRELPPSISDLSLPPPPIIIPPNATVVPDSDSANASPDFLRCTLNVVPTTNSLLKKSKLPLALVVRPYTALHDSEEDVAVSVDTVISRCRRCRAYINPFITLADQGRRWRCNLCNLLNDIPMGFTFDELTNTSKNFYDRPELNYAVTEFVAPKEYLARSPPPCVYCFLIDVSADAVNSGLTATVTRTILESLDRIPNTNKTSRVAFIGVDSSLHYFKFAEGTDGVEMLIVSDIDDPFLPYPDSLLVNLEENRPAIEKLLLDFPGYFEGTANTGLALGPALKSGHKMISSIGGKVIAFAASLPNIGEGKLSVRDEEQSGKPKESQTLLSVADKFYKAFAVECNSAQVTVDLFLTSSKYQDVATLSNLPRYTAGQTHFYRAWSAATAEDVTKFSKEVSEHLSMEIALEAVLRVRSSSGVRGSAFFGNFFNRSSDLCSFPTYPRDQSYVIEVSIEETITKPLVFFQAAVLHSTHFGERRIRVINLALPTSSKLDDVYASADQLAIVNYFTQKAVEKAFSHSLQDARDLLIKSLVDIVSVYKKELVAGNISGSSPLQVSTNLRMLPLLLFSLTKHIGLRAEKVPADYRAIALNNLATLPVHHLIKYIYPSVYSLHDMPDGCGLPEQVTQINEETGEEETVSSTNILLPEAINDSKTSWENYGLYLIDNTTELFLWVSGDVVPGLVHDLFGTENLYTIPFGKTQLPEFSFEESEFNYRVRQIIGKLREQKDQITWKNLYVVVGGSSHEPMEITTQRDLMALRMWATSCLVEDKTGSDQAYREFLNTLKGKVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6A7</accession>
    <name>G3B6A7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_105892</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6A7"/>
    <dbReference type="GeneID" id="18245850"/>
    <dbReference type="KEGG" id="cten:18245850"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066033_2_0_1"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="232" mass="25552" checksum="384DA5CD89DC84A9" modified="2011-11-16" version="1">MSICSVNAVYLNALAKNPLLTKAITAGILNGLNELIASAVSKDYSSFALKPNSKIIQMIFYGSCILTPVSHNLYGVLTRIFGNAGGKNLTPVLKALQIITSLVTITPILSGIFTSWISIINNYKPDTDMAAMVSSSPKKVVVQLKHEILKVKNIVQKGLSQNYPRILRGSLVTNLMCLMVAQNLLSPELWVVFFNAVYFVLNTYQNTRIKIQKKKEVSRAQAEQAHTKPKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6J5</accession>
    <name>G3B6J5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkaline phytoceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_106077</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6J5"/>
    <dbReference type="STRING" id="590646.G3B6J5"/>
    <dbReference type="GeneID" id="18245861"/>
    <dbReference type="KEGG" id="cten:18245861"/>
    <dbReference type="eggNOG" id="KOG2329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063293_3_0_1"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="34037" checksum="5AA54D5C2D4D2325" modified="2011-11-16" version="1">MWLFAIEYPQEQKLGYWGDITSTIDWCEENYVVSDYVAEFLNTTTNAVFILLALFAIYHARQNKLEWRFIFTGLGFLLVGIGSWWFHMTLKYHFQLLDELPMIYATCVPFWSVFSEFRNPKDSVMIGVGIFMGANLLTLIYVWFKDPTLHQAAYGILNFVIIFKSFRLTEKYVSDPVARSNMHKTMSLGIGLFLLGYIFWNLDIHFCSSIRSIRRNVGIPYGFVLEGHGWWHVFTGLGVYYYLVYEEYLRCFLTKTERFYHFQWKFGLPVVYCHDKDGLAKFRNAKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6L3</accession>
    <name>G3B6L3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:flavin oxidoreductase/12-oxophytodienoate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114801</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6L3"/>
    <dbReference type="STRING" id="590646.G3B6L3"/>
    <dbReference type="GeneID" id="18247586"/>
    <dbReference type="KEGG" id="cten:18247586"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_1_1"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="49"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="424" mass="45977" checksum="5F3A7769E7EAF16E" modified="2011-11-16" version="1">MTVRIPLELPAASTGHSAPYPLVKGLDYEYPIPEGVVGSAKELTDKTPKMFQPLKVGNMVLPNRVGVSPMCQYTASNNEATEYHKVHYGALSSRGPGLVMLEVNSVAPHTGVSVVDLGLWNDVQAVKLKPIVDFAHANTSKIGLQIGHGGRKAQGNPPFEYLENWNDPRAIKEEVVGPSAVPFRPKGRLPTPTPLTVEEINTIIKQFGAAAKRAVEISGFDFVEIHGAHGYLLGSFLSAHSNKRTDKYGGSFENRIRFLLEVIDEVRANVPKGFPVLLRISGSDLHDSNPDAWTTADSVKLAPIVADRGIDLIDVSAGANDSDADRPKDKFGKFLPIAAAVKKAVGDKCLVSSVGTLHDAKKVNQLLEDGVIDFAFVGSPFLINPGLVLSWAQELDVSVYQIASHWPFHAKYAEMIEYIKSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6V2</accession>
    <name>G3B6V2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_130580</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6V2"/>
    <dbReference type="STRING" id="590646.G3B6V2"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_1_0_1"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001123">
        <property type="entry name" value="CK1/CK1/CK1-D protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="438" mass="50215" checksum="3B3FA58DF080394F" modified="2011-11-16" version="1">MSAQAGSVNSSANSNSSVVGLHYKIGKKIGEGSFGVIFEGTNIINGVAVAIKFEPRKTDAPQLRDEYRTYKHLQGSEGIPSAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAIQMLNLIEEVHRHDLIYRDIKPDNFLIGRQGLPEENKVHLVDFGMAKQYRDPRTKNHIPYREKKSLSGTARYMSINTHLGREQSRRDDLEALGHVFFYFLRGQLPWQGLKAPTNKEKYEKIGGKKRATPAIVLCEGLPRQFAEYLDSVRSLPFDAEPNYEEYRMLLLSVLDDLGQNADDDYDWMHLNGGKGYDISINKKPNLHGYGHPNPPNERERRHRDQRRRPHHSHQQIQQASAQAQASAQPQQQDLTAAQLHQQKLQHLVNRPLPPIKQESQQKDMLSNSNNYENSPIQRNQYDQQKAEKSQSYWSKMCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6V7</accession>
    <name>G3B6V7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEC14 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114337</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6V7"/>
    <dbReference type="GeneID" id="18247379"/>
    <dbReference type="KEGG" id="cten:18247379"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0492">Microsome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="6">
        <location>
            <begin position="143"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00083195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="355" mass="40632" checksum="6C97339BB9D0A934" modified="2011-11-16" version="1">MFSRLKSKESKGDTTPVPKEALQKVTVPFSAPPASYKVPDPPVLDKSQQDMYLKVHQHFSNPQFVVASTEHDQQQKNKDETKFTALTDAEKAWLTRECFFRYLRASKWNLAECIARIELTLSWRREFGIAGNFEDDNKVNGKLTGAENETGKEIILGYDNDVRPCLYLKPGRQNTKPSITQVQHMVYMLERVIDFMPSGQDSLALLIDFKPTNVGISTGKIPPIGTGRQVLHILQTHYPERLGKALLCNIPLLGWTFLKIIHPFIDPLTREKLVFDEPFPKYVPIEQLDKDFGGTADFEYNHEVYWPALIKMADEKKTKYVKRFEKFGSKVGLSEVDLRGDHDDLVYPVPDVKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6X2</accession>
    <name>G3B6X2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_122733</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6X2"/>
    <dbReference type="STRING" id="590646.G3B6X2"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001127_0_0_1"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="640"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="6">
        <location>
            <begin position="832"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1004" mass="114609" checksum="531B5612D0BBC9A3" modified="2011-11-16" version="1">MNSYGSLAEDSDKSPTGDEDTDIYLVLGNPSQRNRKFIRTSSVILPSTGERVHRKLSFRSSELQPLLLSTNISIQNKAKILMYMAHNFIVEMYQNEKTKSILKCSLAYLIGSLGVYWSVLNRFLGNSDFKHVIATVVVYFHPSRTKGSMHITLIYVIISISFSFLVCFGCRFLSASFYKNGSEEVSMAIDLVVSSVSLGVVAFMKQKVNKETFNTACSLASISIVACIIKEGSMNGAIIPIERLLSTLRIVVTGCFISVAVCYLLWPQTAESLVKKDLNDSFNLMSSILSVIVNRFLKGENLDHKDNELFNRLNSKINNLKKNLADAKYELYFKGKESEWKHLEMLIDITISLVTNLRALRSSTEMQWRLLHESPQDEGSNASLKSFESNIPISQSVENLTRIQEVSNTNDLDYSAINSSQMFDLFVYYLAPSTKAFVFTIKNILNDVPFQYNDNSYRRFVKTAKFQRSLVIATTLFNDKQVASFDKLYDQEIFKSNTNFLFKSDLEEVTACCGNFSSLLGLFGDELLKFLVLLSDNSTTQTKSWDWIKVWSKRQSDGNTDTFKFDSNLNDALLHLQSQYQLRKVDKNDLNVENSVLNLYSNKLWQLIKVFKRIDIQFGIRVGLGAFVLSLFAFYPRTKFFFTNWRGEWSLTIYCIMMNKSLGGTQMTVKWRFLGTFLGSTIAWIVWLLFDGHPFALGLVGFLLSTYCFNIIIYWKKNNAFGRFILLTYNLTALYSYTVEQHDAEDDNEGGDSPIISEVAFHRFISVSVGVIWALTMASIFIPNSARSRLKTGLTVLWLRIGVIWNSDPLDYRRDETDQKDKLISLKGGENALNNLLNELEVLLKQAPSEFRLKGKFPTKKYESLLSSSSKIVDALHNMILIIEVDPILSTNEKFVINYIETERHELEHRIFLIFYMIASSMKLQFPLPSKPASTEHAKDRLLYKLSEVRSNSVNDSVVLCNEDYVLLYSYILVTSTITQELDKIIEVIKQLMGDISEDMFQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B775</accession>
    <name>G3B775_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94473</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687753.1">
        <property type="nucleotide sequence ID" value="XM_006687690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B775"/>
    <dbReference type="GeneID" id="18250401"/>
    <dbReference type="KEGG" id="cten:18250401"/>
    <dbReference type="eggNOG" id="ENOG502RPYN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365629_0_0_1"/>
    <dbReference type="OrthoDB" id="4084947at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="644" mass="74098" checksum="D84609CD1F95A875" modified="2011-11-16" version="1">MPSVRSTLVPNANIIRFLLTAASRVPAINYAASNDSDYVSQMESEKEIPRNYTNLTPLNTKAALLLQVYIGLLNTSISDSEREDIYHEFNFVFSEFIVAPLHQRPFQERNASKQAKKDISNLYSVTSLPTNSPKSRNRQQKEDSADATMYSPSAHSVVEDSEDGFSPISRPRVLEEEIDVFEKFAPTKPTSQNKRSLLDSIGLLSHIAAPSSPRSSRNSPEIPSRVRMFDEELITAKLNPNTNNHYSLWNLVEWMFYCASSASDPQDDLTGIDYHRQLYYNYSTFFTLVLDFVEFDYWRFVEKKVCSIIDCDVKEFMQVVPSLSASEVKLCTKAFHSFDFLLAKLFQQKTPKLIYWFDRGLEAVFSGLDGASRVQQPIPCYEKELELAKKLNKNKSDLINSCVLDSFKIRHKFVYTMYSMSLIYSYIESGNNQPKKLVDEESPLGLSNFTTQLSKKLNSLDPSAVEEFLKASLVHIDDTNYDKESFLFIVLMLRGLLHQTTKGEFSQDLAHIFRVFVNYPEEEFSRHLVAVFDNSSIFRRFMETELSVDSLGPLIQSWNIFQVTCCAISQLLQIWNYRQTVFTVEASFLSKYEVNLTKINSRFSSFLAQTSDWTPEYRTKAVKLKDQLRIVDFTSSWKNSTLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7I7</accession>
    <name>G3B7I7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_135564</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7I7"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF16">
        <property type="entry name" value="7-KETO 8-AMINOPELARGONIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="56992" checksum="DB1DC07679FB0EBF" modified="2011-11-16" version="1">MSDKNCFTVSEKTPFEASTAINDASSDANHQSPLEKRFNVWSTSALQFSLICSALAIGTFLSTVVGVGGSPGLIYGYILAVTFDLFICYSLAEIASAYPHSSAQIHWTYVLAPRGTKRGMSFAVGILSCAGWIFACFSSTYVATGFFYALVAVYNPDFAPTNWQMYLTYAAIVVVGSCINAVAVAALPFITHMLVGIINSTTVFILVALLVKSSPKQSASFVFSTFINETGWSSDGLVFFLGLLPSIASVTLYDGACHMTDEIDKPEVHIPWVMVLSNTSSAILGLVAAIIYMFCTKNVDTLSSPIGGQPIVQLMMDAFESNALTTVGVVALIMSFVGSSFTYYTTTSRLFWSFARSNGLPFGDIFAAVNSTLKVPVNAVGLVTALCLILGLIILGSSSALTAVLGSSMVCINLSYIFPIGALLWRSGFSRNIRTRYADGPDVLSMMVVDPKTALPYFHLGKFGVVLNVASVVWVCFIMVWLNFPTVHPVQSGTMNYACVVLGSTAVVGVIFWFAARKKYDHDVNGKHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7M8</accession>
    <name>G3B7M8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial 15S rRNA processing factor CCM1</fullName>
            <ecNumber evidence="2">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_135592</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="2"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7M8"/>
    <dbReference type="STRING" id="590646.G3B7M8"/>
    <dbReference type="GeneID" id="18249888"/>
    <dbReference type="KEGG" id="cten:18249888"/>
    <dbReference type="eggNOG" id="ENOG502QVB0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434755_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="576" mass="66353" checksum="3F7CC73A09DAFA83" modified="2011-11-16" version="1">MDNIRTAIVRVARRVRTLEQLKQRQSRRTDVGTVGGGTPTVPKSRNQMAGLKVTNELLTQAKPFLQDFEKAKFKEFLAPLEMSGLKLLGDKRPFDARKAVNMWQLKRSTSNLVMHQKFTDSQALLEQTLGLLKRLTPPQVLGPKTDAATLQILEEYEREISKFKFEVPRYFFGEVPKVDASMSSDQFEQYIYFLTHSQVLYRGSSKLNGVVNDILLYTHKLDNHEFKSKRSVTTYNHMIKWYGYNKNQSLFARSLLVAMEKDGIEPDIHTINNLLKMVRVTGRIRSVSEPLKLVNKYLRLCGHYKLQANLVTWTRVYQVLTNVYLKEMFLNRVSMEQVPIPREMVYSVMDDYMVGCSGVTELVQFVERELRMPEQVWQEDSKIFNKVNYMAAKCATSAGEIASGAAGRCHDSHTNEHVIRGLRQNQNLSEPDKINAILWVYKGDSPAVIRYVVDSLSRIEFDIDGMHKATNKLVYDFQQLSSYEKTGDVISSMKSHISSFDAVMAKLQYFKRRIEPKDWEIPVQLDGTNTFVVPEKYLRRRHMGVIKAINRSKLVAATSLGERLREREVVARQPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7N7</accession>
    <name>G3B7N7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_94545</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7N7"/>
    <dbReference type="GeneID" id="18250411"/>
    <dbReference type="KEGG" id="cten:18250411"/>
    <dbReference type="HOGENOM" id="CLU_1004715_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="277" mass="32650" checksum="98944F380D34FD3A" modified="2011-11-16" version="1">MDSPILVPEATPNDYVSITHKSSTASLSTMSDITDLFPSRGYPLIDTIIATPLGELEAASAQAEDFEAVRDHAERIAKSLVRRLEPLRTLGTFDRHIPQWSDEINSFFGDHPDIRDAYESKSCDPTYYVFLKESFPFWIKSFDQEVILSLHQKNKLRHNFDQRSFKEVWQYIKANEVKIHEFKIQRVLRDLMKKHPADWLHYEQGTCFRREYKDYLEFLDNHGCLLIQLYWGLSLQNKRALVNILAQNYQNNMVLRYKDISNVLSCHEDFKKPRNWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7X8</accession>
    <name>G3B7X8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="12">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="4 12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_115141</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="1 12">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4 12"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7X8"/>
    <dbReference type="STRING" id="590646.G3B7X8"/>
    <dbReference type="GeneID" id="18247737"/>
    <dbReference type="KEGG" id="cten:18247737"/>
    <dbReference type="eggNOG" id="KOG2424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062463_0_1_1"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="230" mass="26108" checksum="4F9298283E38B116" modified="2011-11-16" version="1">MSATITQAVPDSLRVCTVCAANNNRSMEAHKQLKDAGYNIKSFGTGSAVRLPGPTIDKPNVYQFGTPYEDIYNDLMSQDCRKLYESNGLIHMLTRNKQVKRAPERWHANSYAGKFDLVITCEERCFDSVVDDLMFRLHNNDYNDNEVKQVVHIINIDIKDDNENAVIGGNGIVKLVGMVHNFKRQEKKKLAEGTIDDVSDAILEDQMMGILAEWQKDHAHLQTIYTCAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B858</accession>
    <name>G3B858_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_115819</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B858"/>
    <dbReference type="STRING" id="590646.G3B858"/>
    <dbReference type="eggNOG" id="KOG3190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048802_3_0_1"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="359" mass="41993" checksum="9F11F63F06D08BA7" modified="2011-11-16" version="1">MSEVGVGWFCVRTRTYLHRDKSGNRDSHMGFLELARSDKSRGRSALSAVVRGNLAVGWRYWVFSQRFPSPPVPARGKCRAHRITKNIYHPMKSITNRRFDDSDDEDVLARTLKRRKQDSQKNDAENDAFGGLSLGSLSSAQKQMYQDQSQHDSDDTNDNHKSSHKPQHKHKPAKGPQQKKKHKHAPTETSSKKPVSRIRNLSDVVTPKYAGTLHQDLRFDAAYGKADLREARKNYAFLDDYRQSEINELQALIKDRKSFGMLSIREQNDARDRLQSLKSRLDTLKNRDLEHKILDDYKKEQMQNFRDGKQSNPYFLKRSEQRKLIQTAKFESMKPVQREKVMERKRKRKLGREFKQMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B869</accession>
    <name>G3B869_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_124720</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B869"/>
    <dbReference type="STRING" id="590646.G3B869"/>
    <dbReference type="GeneID" id="18249048"/>
    <dbReference type="KEGG" id="cten:18249048"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_4_2_1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="339" mass="38533" checksum="5E13DEFED72AF5EF" modified="2011-11-16" version="1">MGQLLSHPIEEKTIDIRSHTSLTYCIGSMQGYRASMEDAHSVKVNEDESLGLFAVFDGHGGREVADIISETLPKMLFTKLNQMVKRGAELKEYMRFIKDSFFKVDSDLPPESSANCGTTAIVVMIIEKKYIIVANTGDSRAILSLRGGACKTLSFDHKPSNMGERVRIENSGGYVINGRVNEILSLSRALGDFKFKVPFVELDSCHNKYAARNKKYFKHDLIHLPPELLQVSCEPDLLIYDIKQLRQPEFIVLACDGIWDCYRNEKLIKVIRDKLALDWSLQHIIEFVLNDCISMASNITGIGFDNMTLIIIAIHDENTSIDEWYEMMKTRILKEKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8I2</accession>
    <name>G3B8I2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-related protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Actin-like protein ARP4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_115193</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the actin family. ARP4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8I2"/>
    <dbReference type="STRING" id="590646.G3B8I2"/>
    <dbReference type="GeneID" id="18247763"/>
    <dbReference type="KEGG" id="cten:18247763"/>
    <dbReference type="eggNOG" id="KOG0679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_6_2_1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000203">
        <property type="entry name" value="Actin-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="466" mass="52523" checksum="4D139EBAF0673309" modified="2011-11-16" version="1">MASANSNANVYGGDEINAIILDPGSLSTRIGYAGDDFPKIITPSYYAANGKKHIFGDSINVPRADFDIKPILKDSVIEDWDAAIEQYHHYFDKELALDYKEQPIFITEPIWTSAKQRQTLVENIYEKFDFPALYLGRAPTCVSFQQGRPNCLVVNIGHDTVSVTAVIDGISLLKNSMRTHYSGQYLSDQLYDLFLNKFPSLTLDAKYKIRTKTPTKYPEPPVFTPRELPKNITKSFDDYQKELLFHEMKETLLEAPDKQITDENSESYSKDENRRAFELPNGQSIELAIERYEMADSLFEPNNYSFTNETLANKYSVENGSLTIDSNQDDYRPLKRARKNESNQSTPPPAATEPSVAETRGLTQLISHVLSTIDIDLRASVAHNIIVTGGASLIPQVTERLYSELSSLNPGLKIRLHAVGNSSERVNQAWIGASVLASLGTFHQMWVTKEEYDEAGPDKILNQRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8K4</accession>
    <name>G3B8K4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Noc2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_115204</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8K4"/>
    <dbReference type="STRING" id="590646.G3B8K4"/>
    <dbReference type="GeneID" id="18247768"/>
    <dbReference type="KEGG" id="cten:18247768"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011272_1_0_1"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="38936" checksum="86FC61140EEDA5EB" modified="2011-11-16" version="1">MPLLNFCKNSAAELYGIDETVAYQVGFEYVRQLAIHLRNSINATSNAKEGYKTIYNWQYCHSLDFWSRVLAQQCNPEKELQTHKSKESPLRQLIYPLVQVTLGAIRLIPTAQFFPLRFYLIRSLIRLSQSTGVFIPIFPLIIEVLNSTAITKNPKKTNLPPFDFENNVKVNQQYLGTKVYQDGLTEQFVELTAEFFVLYSKSVAFPELTTPAVISLRRFIKKSKNSKFNKQLGQLIEKLNENAKFISGKRSNIEYGPSNKQEVALFLNDLKWEKTPLGQYVVVQRKVKEERLRLLKEAIEQDEEAKSKRNDMDEDEEAEAALDEVESDEDEEEESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8P8</accession>
    <name>G3B8P8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115864</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689070.1">
        <property type="nucleotide sequence ID" value="XM_006689007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8P8"/>
    <dbReference type="GeneID" id="18248059"/>
    <dbReference type="KEGG" id="cten:18248059"/>
    <dbReference type="eggNOG" id="ENOG502QRJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017366_3_0_1"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="611" mass="70192" checksum="C3479880BE87E0AC" modified="2011-11-16" version="1">MKLSVFHKYITVVLLVINVAFVYKYLHESPLSIPNVFKSTSLSEKFEASLPQNSDPYTIYNRLPIDLANASAVFNTVEGALKQKDANTHPVGISFIPAYIPPNTRLYHSRSDGNVPHSFEWVAFDYEFSYAFAGFQRSTNSSGVIEHNWRGREHTLFTFKNTKSLDKLIFLDGASAAKSGSEMDQQMILSNQTNTTEYVDERVAADKICKWGEKFGLQGIVRLEVGYEMILCDFHKDIELVSNVTLGVVNDLIGFPPDEHKYVHQHPYKPHRKAGDHPHPKGSSDPKGPPGGEFYKYYDYGKRGDEVDDIPDYESLSYNRSLLLSHLRLETGFEWGQAGNTHDFGEDRILLDFSNMVTPINKTYIDPNAYRRNISYISQDLKDDIIHSFEQIYKEPTVPFYKTNWQSITGAITQKFGPMLVNLNSSLYHENLKEVSDRIQLLTFNFVRRYTNDATHGSATQREAAIKISIDDYVFHTFHLRNTDFLIYASIYKVQSEIVNFIFDIFDFSKDLAHDIYIKGEYTSHDEELKRIQKRLSDMLELFNWSISYQCSQTCAFDETCYTPTWGPGPFGWGIQGNTDFFDYDGKTYSIKHEMSCIKYTDAQKDIAPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8T3</accession>
    <name>G3B8T3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115887</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy; may act as an adapter for ATG8 that supports mitophagosome assembly. Negatively regulates the proteolytic processing of ATG32 via the i-AAA protease. Acts as a negative regulator of the m-AAA protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. The mitochondrial prohibitin complex interacts with the m-AAA protease, a heterohexamer composed of YTA12/RCA1 and YTA10/AFG3. The mitochondrial prohibitin complex interacts with ATG8 and the interaction may support mitophagosome assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8T3"/>
    <dbReference type="STRING" id="590646.G3B8T3"/>
    <dbReference type="GeneID" id="18248070"/>
    <dbReference type="KEGG" id="cten:18248070"/>
    <dbReference type="eggNOG" id="KOG3090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="9">
        <location>
            <begin position="53"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="301" mass="33457" checksum="014FF9AD658F4696" modified="2011-11-16" version="1">MSDQNWKKLQEELRRRAATAASPGRGPPRPPFAAAAGIGGLLLLGTVMLAQNALFNVDGGQRAIVYSRVNGVQPRIYAEGTHFIMPWLQRPIVYDVRAKPRNVASLTGTKDLQMVNITCRVLFKPDVFQLPDIYRTLGVDYDEKVLPSIVNEVLKSVVAQFNASQLITQREKVSRLVKENLVRRAKKFNILLDDVSLTFMTFSPEFSAAVEAKQIAQQDAQRAAFVVDKAIQEKQQLVVKAQGEAQSAQLIGEAIKKSKDYVELKRLDTAREIAGILANSPNRIMLDNDTLLLNTVTDGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8V2</accession>
    <name>G3B8V2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subunit NUHM of NADH:Ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115225</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8V2"/>
    <dbReference type="STRING" id="590646.G3B8V2"/>
    <dbReference type="GeneID" id="18247779"/>
    <dbReference type="KEGG" id="cten:18247779"/>
    <dbReference type="eggNOG" id="KOG3196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_1_0_1"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005725">
        <property type="entry name" value="PRK07539.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="245" mass="27216" checksum="BA7A414447335267" modified="2011-11-16" version="1">MFRSLAKTFVGPATRPATRPTSLSSKRFSSIISVHRNKDVDNPSLPFEFTSENLKRADEIISKYPPQYKKGACMPLLDLGQRQLGFTSISVMNYVAKMLDMPPMRVYEVATFYTMYNRRPMGKYNLQICTTTPCQLCGSDEIMEAVTSHLKVKPGQTTPDGLFTVQEVECLGACVNAPMLAVNDDYYEDLTGSKTVDLLKQLQAGKELKECGPVSGRESCEPYSGAKVLLGAKPTDIRKFTRADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B960</accession>
    <name>G3B960_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription factor TFIIIC, tau55 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_109006</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B960"/>
    <dbReference type="STRING" id="590646.G3B960"/>
    <dbReference type="GeneID" id="18246077"/>
    <dbReference type="KEGG" id="cten:18246077"/>
    <dbReference type="eggNOG" id="ENOG502RYP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042838_0_0_1"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000034">
        <property type="entry name" value="Transcription factor TFIIIC subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014623">
        <property type="entry name" value="Tfc7/tau55"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036802">
        <property type="entry name" value="Tau55_TFC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="273" mass="31013" checksum="ADB4301CCF933307" modified="2011-11-16" version="1">MALKHIYIARHGYRMNWLPPPHPPNPTGIDSDPPLAPHGVDQAKELAEYIASLPHNQQPQFILSSPFYRCVETGEPISKALDIPIVLERGVGEWYKVGRGVIPEPANYDALSKFFSHLSNADEWDRDKTVGVVPSLTGETETDIFARCKFFWSKFFSVFESKYPHIENILIITHAATKIALGMSLMGFNDVFEYLDKDETVLRAGACSLDKYQKVGETWELKMNGNCEFLSQGEEMNWDFHSGFEAGSDEDIKARRLAAEREKQANQDMQVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9D9</accession>
    <name>G3B9D9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115953</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9D9"/>
    <dbReference type="HOGENOM" id="CLU_1975723_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="127" mass="12774" checksum="59F04FFD046680B2" modified="2011-11-16" version="1" fragment="single">VTTIILPCTCKEPSTTTTTGDDGKKTVVCNIPHSLVSTVVVTEPCTNAAGDVTVTTYTTFTAAAAAVTASPTETVSPTGAKGSGSEAASAGNGSGTAPKEISTYEAMGSKNTYTFLAVLSTLLWISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9K1</accession>
    <name>G3B9K1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_131376</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9K1"/>
    <dbReference type="STRING" id="590646.G3B9K1"/>
    <dbReference type="GeneID" id="18249520"/>
    <dbReference type="KEGG" id="cten:18249520"/>
    <dbReference type="eggNOG" id="KOG2429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_5_3_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442817" description="alpha-1,2-Mannosidase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="804" mass="93180" checksum="3AD4884F7DAB2675" modified="2011-11-16" version="1">MLRCILWVLWFTTISTCAEVQFPKFEATSSFNSSFTPDHMRYLRNETKSLFDHAWTSYMKYGFPMDEVRPITCEPYGPDVKDYTNVIRNDVLGNISSTLMDNLDTLVILEKWDDLEMALGYLYREKDSYFDKDVVVQVFEMTIRSLGGLLSIHTILSDSSLMKNLRFRQICQNYDGFLLEMAYDLGKRLIPAFKTTNNIPVPRVNLKRGVKGVPSSLQLETCTSGVTTPVLEMTLLSKLTGDLQFEKYTQLAFWKIWNSRSSLDLLPMTISPAESEWKDSITGIGASIDSFYEYCVKGSILFDDTHMWEVFKTSYKALMTHSVKGSPDEFTSLIFANIGSEEGLDATIWIDSLSGFWPGVQVLSGQLKDAIGTHMVFLKLWDYFQIIPERWNFLLPKEAIKSEEDTIGLEWYPLRPEFVESTYYLYQATHDPMYLQIGETVLNLFKTKFMAPCGFKGVQDVRTGSFQNRMESFVLSETLKYLYLLFDEQNEVFLHSKRMGDTNWVFSTEGHPLWFDYNTEKTFKGSNITPKKHEFVAEGHRENSMFKSFKGLFSTTRKLKDGTTKDITIEYIDDHEFVDPFQYKFDKCEVNPFTSGSTDFMKSSYYELDNLFNLDYEYSSHLYHPHYLPQTSLDNSYIELADDFYKRFTLFNPKLTCSLQSNTEKFDIFIGDKTSIRNNSLTLIPSSNTLWIHEFDNVRLSMELIQKGKIDSRHNYITQQQVETTNSRLVEGVLDPNITLYDASVRITRINGVFVKPEHELVVSRFTQDQLKRPGANKRKDRLTIYNSQVLLDGVVIENLRITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9W5</accession>
    <name>G3B9W5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114808</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9W5"/>
    <dbReference type="HOGENOM" id="CLU_2885561_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="63" mass="6929" checksum="C25FBA71DC52576A" modified="2011-11-16" version="1">MALKFGVLSSTPKKENFDSLPPASSAALGNLRFFNDMSFTFFYRVLILADYTTSIGVCSGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAC9</accession>
    <name>G3BAC9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115489</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAC9"/>
    <dbReference type="HOGENOM" id="CLU_1471561_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="184" mass="20296" checksum="7F97BC01B7C6B7A2" modified="2011-11-16" version="1" fragment="single">MNQAQQPPMLGVPPQDVRQGISQGIPQGVPQGIPQGVPQGIPQGVPQGVTPQPFHAPQAASEPVEPTPSAPQAVSMSEIIASSPNDELPVHAPRKQTKPVNLSQFPVLGSKEAPLSGGRLQSQRQAFESRQSHERQPFERQRHDFRQGYERHPYENREVHEQIALTPEQQAKAAKRQEKVSRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAG7</accession>
    <name>G3BAG7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_125552</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688226.1">
        <property type="nucleotide sequence ID" value="XM_006688163.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BAG7"/>
    <dbReference type="GeneID" id="18249109"/>
    <dbReference type="KEGG" id="cten:18249109"/>
    <dbReference type="eggNOG" id="KOG3628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000737_0_0_1"/>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056881">
        <property type="entry name" value="Mug62_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24919">
        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="148"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Meiotically up-regulated gene 62 protein-like alpha-beta" evidence="5">
        <location>
            <begin position="650"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="897"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="1379"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1558"/>
            <end position="1578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1578" mass="175774" checksum="1391D9BF5674F92D" modified="2011-11-16" version="1">MSSSTVAGTGPGRQRASSSVNLPPEIAMASATDANMTTSSNVIGANPNIGVTLGTGYGSISHDIPPDMAVLLQNLEEDFTVHKTIDQWTYINRREEIIQSINKLRQQQIEQIKLDPDSLEKPLFPRQPSAIVKDQKFSTNTLLNILKRRATTYKSENAFLVLDLKGKEVSAITWDKLYLKAVKVAYEITHKLSLKNSDTVILLYKEGEVAEFAIALFGCFMAGVTAVPIHQDVSLYEVLDIINLTSSKLVLYSESVAKELDRLNSNGSRIVWPPKLTRWRTTEFGSVKKSDLSAWDSKHNQKKQDETRSKADLAYVEFSRSPLGELRGIALSHRTIAHQMSTLSSSLSSSPSSDGIVRNDKEYRRNRKVFMATLDIRFSIGLILGILFTVYSGNILIWAPQKVMEIQGLYANIVSKFKASLLLTDYIGLKRVTYDYQQSPNATRYFSKTQRVDLSSVKWVLVNSLTTDGEFMEILANRYLRPLGCQEPENAIIPMLTLSEYGGMVMSMRDWLSDEKPGSNNQSKGELTSLLIDKEELSRNRIKVVETNTSASDDTSKDLLRVDAFGYPLPDATLAVVNPESSVIVEKGEAGEIWIDSPCLSGGFYGLLKESKSIFHAKCRDADGIMEMDFLRTGLLGFTFNGKVYVLGLYEDRIRQRITWIDQKVYSKQGKELVIGNGTIYHYSSHLLATLANEVRQVYDCTIFDVFIGNEYLPVAIVEAEVIRKILEGTSGDTSNSSSGRGDSAGPQYDPIPLNEPVLNAIAQKCFDTLYKHHLLKLYCVLVVDCDTLPKIMRSGGREIANMLCKKKFLEGSLKAEFVKFFVKKSISLIPHGEDVIGGIWSPYVSQLRSVALGNFTPQLSQVIYKEKSLDDKTGAPLTDFKSIVDILKFRVSHGGDSIAFQNLDHGKSSSKPLTWKKFELRIYGVVSYLIEKAQVKPGKYVILMYSLSEEFIVAVYACLMCGIVAIPMLPFDSNRIGEDLPAFLGVIKDFDVSDILVNEEVERFLKSGPAAESLKRMNVKRYKNWKIKNTAKLTKVSNIASLHSKISKYQAAVNFRDEKTTALIWLNFTSDHYRVGAKLSHKNIIGICKVFKETCNLTSKSAIVGCVRHCSSIGFVQAALLGVFLGTTTYLCSPVSYAENPLAFFLALARHKVKDVFVTEQMLKYAAIKFSPKGFDLSHLKNMIISTEGRVEIDLLRKIAKVFQPTQLSAASMSSVYNHWFNPMISSRSYMAVAPVDLYLDPIALRQGFVSIVNQVDFPNALHIQDSGMVPVCSEIAIVNPETCKLCKEGEFGEIWVSSEANLTGFTNGPKGPVDSFAESQFLGKIVDGDKTITYLRTGDLGFLHHITIAKNKTGKKSNDEQEITSFQPLFVLGKVAETFEVLGLHHFPIDIENTIESCHSDIYKNGSCVFKCADYTIVVCESKRKRNCASLVPIIVNTVFSKHHLIVDIIAFMKKGEFPISRLGTKQRARIIDAWVQGIIPVSAVYGVNYGENSMIQLIKEIDSVARDNPITGLKNPALSYYDADPVDDKSSIFDSNRQGLTLNDDYEDYYNSLEPNTTNSSVGPDYGSHKATFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAI5</accession>
    <name>G3BAI5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114888</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAI5"/>
    <dbReference type="STRING" id="590646.G3BAI5"/>
    <dbReference type="GeneID" id="18247623"/>
    <dbReference type="KEGG" id="cten:18247623"/>
    <dbReference type="eggNOG" id="KOG3259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090028_0_0_1"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="62"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="174" mass="19751" checksum="875EBFC008177F5D" modified="2011-11-16" version="1">METGLPENYAIQVSRTHNREYYVNNVTGESSWEPPAGTDKQKLDKYLEEFENNGYKPLVNSNKQVRATHLLVKHNQSRRPKSWKSPDGITRSRDDAIRLIKQYREKVLKENIPLGDLAATESDCSSHSQHGDLGWFGKGQMQPPFEITSFNLNVGELSEPVETDSGIHLLLRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAZ0</accession>
    <name>G3BAZ0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein CFT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cleavage factor two protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Protein cft1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_109087</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CFT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BAZ0"/>
    <dbReference type="GeneID" id="18246085"/>
    <dbReference type="KEGG" id="cten:18246085"/>
    <dbReference type="eggNOG" id="KOG1896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002414_0_0_1"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001516">
        <property type="entry name" value="Protein CFT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="11">
        <location>
            <begin position="13"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="12">
        <location>
            <begin position="499"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="10">
        <location>
            <begin position="943"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1300" mass="147799" checksum="A3A771C70239EB2A" modified="2011-11-16" version="1">MEAYNEFIEPTRVSHCVGAHFISPSRKHVIVAKTSVLQVFEVLRVKKSFRLNLVDQYKLFGTITSIKPIRTIENPKLDYLLVATQLAKISLVRWDHASHSIRTVSLHYYENVIQTSTFDKLNSAELIVEPKNACLCVRYKNLLTFLPFTRLKTEEDEYADEEDGAVTNSYDGIYDSSFLINGQNLDSRIGTIVDADFLHNYRQPTVALLSSKDQVWAGNLFFKKDNISYIVLSLDLNTKKSTTVLKIDDLPYDIDRLISLPSPLNGSLLVGANQLIHIDNGGITRKISVNPFTDLTTKNSKNYINYSHMNLRLENCSVVPLPNENKVLVILSTGEFYMLTFEIDGKTIKRLTFEVVETSRYNGINVTFPGQFAALDNNLLFVGNKNGNSPLIQYKYEGAKEKAVKEDAKDEEDNDGDEELYEDDEEKVKSFSKEKLDFTLCDELINHGPISAFTFGFYSNEKFKSNLINPNYQEVSIFSNSGSHKQSHLNIFTPSIQPTIKSSLTFSTINKLWISNNFLITSDDKNRKSEIFQVNNNFARVKSKDFINKNLTIAIHELNNGKFILQVTPKKILLYDNKFKKKMALNKVLDKEKEEEVFNSYCTDEILMLFLTNGDVKIIAINTYNETFTEISIPKILSDTIITTGYVTNSNILNAVSKDVNLLIKNKKRKFSNLAGDSISKESEESLGPKQKVFILVTGDNRIVLFNRSHNERCYQLNDIDKFTDHLHLGFFENKDSYPDPFIKQVMFNEIGNEISKSQYLTVLTIGGEVILYKLFFDGENFRFLKEENLLITGAPHSSFNVTTKVERQLFHIENLSGLTGIFVSGDVPYYIVKTNHSIPRIFKFARIPIMSFGKFANNQLIFLDDKKNTRICEIPSEFNYENNWPARQINIGETIKDVAYHETSNTFVISTYKEIPYNCLDEENVPIVGIMEDKPSALSYKGSIKLVSPISWTVIDEFELDDNEVGTKVSSMVLDVGSSTRRFKSKREFVVIGTGKLRMEDLAANGSFKVLEIIDVIPEPGHPETNHKFKEFYKEETKGAVTAVSDVSGRFLVSQGQKIIVRDLQDDGVVPVAFLDCSVYVSESKSYGNFVLLGDTLKSVWLAGFDAEPYRMIMLGKDLKSIDVNCADFIVKDEELYIIVGDNNNILHLLKYDPEDPNSSNGQRLVEKAAFNLNAKVTQLKQLPNLMDNSTSCIGSTIEGSFFTVFPINESSYRRMYILQQQLTDKAYHHCGLNPRLNRFGGLKLTANESNNKPILDYDVIKLYAKLNEDRRRNIGAKVSREGSEIWRDMLEFEAGVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB00</accession>
    <name>G3BB00_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114963</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB00"/>
    <dbReference type="GeneID" id="18247654"/>
    <dbReference type="KEGG" id="cten:18247654"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037966_1_0_1"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833556" description="ribonuclease T2" evidence="5">
        <location>
            <begin position="18"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="311" mass="34781" checksum="8F19F8EDA88B523D" modified="2011-11-16" version="1">MFIKPFVLLAGSLSIFAYPNPGFAAKRSDTQSCSAFMANPSSTYSCENSTTVTSNSCCFERAGLMLHTQFWDYDPDKLSSAKKRDLGYSPVHRNKKRSGAPSSSYPINKSFTIHGLWSDYCATSSGKSAGYPASCDADLAVPDSVNLSDLIANQFNKPDLYQLMKTYWVNTESSNVAGDSDEELWAHEYNKHGTCMNTVRPECFTGVYKQYDAAVEFWQKVTKVWDGLNTYEFLESASIVPTTDNTYELVDIKSALQEAFGKDVYVSCKDGALNEIWYYYHVKGSILTGDYKPVDKIGSDRCPDEVYYIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBJ5</accession>
    <name>G3BBJ5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_124376</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBJ5"/>
    <dbReference type="STRING" id="590646.G3BBJ5"/>
    <dbReference type="eggNOG" id="KOG2231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008515_2_0_1"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ribosome binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="PAH_ZNF598/HEL2"/>
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        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV61554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="599" mass="67410" checksum="6598E61334A1B92F" modified="2011-11-16" version="1">MADIPVKSRVGQRSSKRTTNGAKNKGFKGQGDKSTSGDEFDDSSHQCVICAETLEYVAYTPCQHKTCHRCCLRQRVLYEKQNCLVCRTANDVVVISEQLDGDFNDFPQTKLQIHDEKCKVSYTSEAVRNACTELLEYKCSVKGCGLIFDNFKDLQDHTKSEHNKFFCLICYNNKKAFISELPLYHSKALNNHQQVGDQKGFKGHPACQYCFKKRFYSEDELNVHVRDSHERCHICDQDNPNTATYYKNYNDVYDHFKSNHYVCSIQSCLDKKFVVFREDLDLTAHMLKEHGAITGANDRIVIGAGRAYQSQLSTYPRNPARSNGETDNSDPQDVKKMRLEERAKHYLEYQNQKIQQFLAINKTFKSGTIDADEVAKSYKELFATQSPEEIGILLSEFAELFPESSSKFASLKKEVETIVKNSNQYDFPILGGSLQGSAVNLHNWGGSPSGSRNSSTDKFPVLSKAKPKNQAPSISAAKQPIRYTTVVHQQPTLPKSVNIHSFNNDTSYRPSYLDSSSSASNSAPKAPSASNGVSLSSSKFPALEKKTTKRVFPRVNAVQVTPASSWGTPVLQKVPVEEDNWGIPIIDKRKQKQKKKTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBQ1</accession>
    <name>G3BBQ1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1605-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115671</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBQ1"/>
    <dbReference type="STRING" id="590646.G3BBQ1"/>
    <dbReference type="eggNOG" id="KOG0924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_976587_0_0_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase-associated" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="285" mass="32674" checksum="40CB214DCA0FE54A" modified="2011-11-16" version="1">MSNFPMEPSLSKLIILASSSQFKCSLEILIIVSMLSVPNIFYRPKERVNEADSAREKFVVGESDHLTLLNVYQQWEVQLRKPSTNMGKLMAWSNRNFLNNKSLLRAREIKNQLVLIMKKMKLPITKAQDDETVKKCLCACFFNSAARLSKLNLTNTNSIEYVNLRHSFMKMYLHPTSCLNNSANVPPSFVIYHELILTAKEYMSCVTAVDPLWLLEFGYIFYGVSKHDQKKFLSFDIGFDLIDKGLFAAGLEADKKRFGEKKAAAKQPVSYKETKVSRFKTRRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBQ3</accession>
    <name>G3BBQ3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_115674</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBQ3"/>
    <dbReference type="STRING" id="590646.G3BBQ3"/>
    <dbReference type="GeneID" id="18247961"/>
    <dbReference type="KEGG" id="cten:18247961"/>
    <dbReference type="eggNOG" id="KOG3464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_1"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="106" mass="12232" checksum="2B9B66B09B75E05C" modified="2011-11-16" version="1">MVNIPKTRKTYCKGKECRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFKKKAKTTKKVVLRLECVNCKTKLQLSLKRCKHFELGGNKKQKGQALQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCB5</accession>
    <name>G3BCB5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116861</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCB5"/>
    <dbReference type="HOGENOM" id="CLU_1781858_0_0_1"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="146" mass="16603" checksum="F7502AA1AC4E39BF" modified="2011-11-16" version="1" fragment="single">MSNYQDLEMVNDFTDLERFLSYSLKSSSLIHRVTKNYQADEKISINDQIQKYLKLRASFKQTQSKRNKGNKKLKSTSMPPPDPGPVPESFNGLNNFGSNLLTENNLFDKLIINDFNDVSATKACAICSKSTCFCLDTDKKYSDSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD10</accession>
    <name>G3BD10_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116941</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD10"/>
    <dbReference type="STRING" id="590646.G3BD10"/>
    <dbReference type="GeneID" id="18248515"/>
    <dbReference type="KEGG" id="cten:18248515"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="286" mass="30609" checksum="4A0C50FED46E4958" modified="2011-11-16" version="1">MPITREFIENGPWKPDLFRGKVVFVTGGAGTICRGQTEAMVLLGANAAIVGRNVEKTEKAAREIEQLRSGAKVVACSGTDVRDVHSLAKAVEKTVQELGRIDFVIAGAAGNFLSDFNHLSSNAFKTVVSIDLLGSYNTAKACFEQLRKNKGSILFVSATLHYYGIPFQLHVGAAKAGVDALSNALAVELGPLGIRSNCIAPGWIEGTEGFDRLMGGNLKRKVPLQRYGKVEDIAQSTIYLFSPAADYVTGTIQVVDGAVWHVGSFIGDDVYPVRIIAANNEPIGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD81</accession>
    <name>G3BD81_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_136749</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689476.1">
        <property type="nucleotide sequence ID" value="XM_006689413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD81"/>
    <dbReference type="STRING" id="590646.G3BD81"/>
    <dbReference type="GeneID" id="18249998"/>
    <dbReference type="KEGG" id="cten:18249998"/>
    <dbReference type="eggNOG" id="ENOG502S91V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285753_0_0_1"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1110" mass="127741" checksum="3248B8EEE6167A52" modified="2011-11-16" version="1">MTKRSDSDSDTNSNDNTQSKKQKVKLDKDSSNFKLITTSTGPRVSQACDRCRIKKIKCDGLRPCQNCSKINFDCKTSDKLTRRAFPKGYTENLENKVKLLEEENRKLKLRVGDADDEQSHSQTPVSINPNEYNDMGNSRKQVIISKNNARVQINNPIDQIFNLDKKGIIIGNDNLNFESQFNHLLINLNLPFLKITNSHNYLLDDPNSYLYHPSSALYNSFHNRDLDVIYNPLTSSNKTHDSYLGAVSNLTNNELPIDIYDLFIKLINSFKKIFSNKKELDNQITSFFLNYNIFIPIFDYKKFMESYDNFHTMYPFMFTYDDATINGFNLSNNDYSVVNEYLMVVIQIYAIIMMNNPTINLNLLLNHSSPYYALNSRSSSKNKNIIRSLYDFLPYLNVFHVSISQLQTCLLFLYYSLLTNNKEKSLVLSSLINAFIGVLGINLNSKNLFFNDLSLDIQQRRDRVKIFWVFKVLLKCFNLKFGFKPSLNTTVINPVTIDRYFQLTPEKLSSLLESEIAPTEDDDEHVDELFKTLLKPSIEFLNLVNIIIPSSFSPNYYQYLKGSNHSNKKSQQHHPKNLDWILNDDDGDGNDGNLNYNFNQFVTIDNNLAAWRESLKTKTLNLVPLEYKMNLSKISYDYGDTSLYHSIKINNLTDLANTGITEEEMNYYLENGLPDISTTVKMIQIQLNFHYLVIRSSNYLNFIVDKELSAHYYSKIVEISKELLGYFVVIFSHVTQAVDGASDPALTVSKSFIHHNPHSTGTNPVILDSLGIDVDEDGFVINDFSAKRRRTSNQAPSFSFKSKTLPSSPFNFMLNGLSMTVINLKKTILLQMLYILICSIKSIKKNNQIDSSLNDLVNVSVDVFIKVFVNYQLNSKKKNSTGISKLKEDELYNKLMNDELKDQILREQRIEEEENEEDYVDYQLEFENTDYFSGFNQISEIDWDDEEMDEDLKILKILKFIKYKMNQIKELAKRRQKLKHKLHTPVDETPKTTKATVKPEPTVQFSPPPSIHNFYTSSNPPKYPPNLPKIPSISKLDYLLPEDNFPTHTIAGNFTKSKDYVIAPSKRDDDLVKREQLAVNDLMSLKNGHGSPTGLESYRKSGASTNTSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDJ8</accession>
    <name>G3BDJ8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_136799</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDJ8"/>
    <dbReference type="GeneID" id="18250002"/>
    <dbReference type="KEGG" id="cten:18250002"/>
    <dbReference type="HOGENOM" id="CLU_593110_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="461" mass="52252" checksum="02C4469155AB4832" modified="2011-11-16" version="1">MPTNHANSETQDYERAEFYCSHLKEFAIFLGLVDPGKFEEKGIPVQMRLMYYLLNLLGFLLKGQMIELKGCAKSIEGIIQKEREAQWKTWTSQGQISITINISQSNESIAFQLYWLNNMEFVSLYRLVTGVGLISQGLAAAALAPLKSGLRAMSSLMNGPEFNAVPFCGSLGQLNNHLVTSGRIIFNFLFYIEWIKSLNQINCDICGIIEDSDGLVSKLNERYLTNCDNFTVAHIYQRKDQYLKTLIKLKSHNLNDSVKCFSQLLTQTSLPVDIKVFSIIQNINALLEVRDSLSHDDDSYGHTMVTIQNLKNMLNDFMNSKEKYEHGSFLQANAEVVDMILVISLVAEPTSTKNHHKIFGVLKNLNQDEICTPFLKILTSLICSFNESSLVTADERLQDCFKASKRLGKSYNDNVLRVAISKGEMYLLEKKGAPAAEIEEIKFRIMEIEKTQSNKTQRNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDM2</accession>
    <name>G3BDM2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_111197</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDM2"/>
    <dbReference type="STRING" id="590646.G3BDM2"/>
    <dbReference type="GeneID" id="18246257"/>
    <dbReference type="KEGG" id="cten:18246257"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="113"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="212"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="306" mass="32164" checksum="17A2D1FE8C0E7A75" modified="2011-11-16" version="1">MASSATGLPNYTATDYAKFALAGAIGCGVTHGAMTPIDVIKTRIQLEPTVYNTGMVGSFKKIVAGEGVGALLTGLGPTILGYSMQGAFKFGGYELFKKTFVEYLGLETSKNYKDAIYIGSSALAEFFADIALCPLEATRIRLVSQPTFANGLIGGFSRIFKEEGAGSFYNGFTPILFKQIPYNIAKFLVFERASQAIFGFVPTPKSELSTLSLTGIDLLAGIIAGCSAAFVSQPADTLLSKVNKTKKAPGQSTIGLLGQLAKELGVKGSFAGLPTRLIMVGTLTSLQFAIYGKIKGALNCPPAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDV8</accession>
    <name>G3BDV8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_95841</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689609.1">
        <property type="nucleotide sequence ID" value="XM_006689546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDV8"/>
    <dbReference type="GeneID" id="18250550"/>
    <dbReference type="KEGG" id="cten:18250550"/>
    <dbReference type="HOGENOM" id="CLU_2133198_0_0_1"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="113" mass="12606" checksum="2B635D9558790655" modified="2011-11-16" version="1">MVANSTNISKKLFRTQKLITAGILAVLIVFLVILSVSSHEHLKNTELFKQTNEKLKSYYSDIKDNVGKPEDVLETEAQIPDQVQEKLHPGDGEGAAKQLNEEMNALIGEKEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE79</accession>
    <name>G3BE79_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_109812</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689693.1">
        <property type="nucleotide sequence ID" value="XM_006689630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE79"/>
    <dbReference type="STRING" id="590646.G3BE79"/>
    <dbReference type="GeneID" id="18246144"/>
    <dbReference type="KEGG" id="cten:18246144"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005386_0_1_1"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="432"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="703"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1057" mass="122623" checksum="C5C4F7DE37D21C45" modified="2011-11-16" version="1">MSTPLTAEEKRLQNPKYRNWGCFTAERQWSTVREDYSVDGDAWSDFSFEHSKSRTYRWGEDGIAGISDSYQLINITMALWNGKDPFLKEKLYGVTNSQGNHGEDVKESYFYLDNTPSHSYMKYLYKYPQNEFPYKQLVEENGKRSRLEREFELSDTGVFDNNEYFDVVIESAKDDDPDGDEILVRVTAYNRSDKAAPLHILPHLTLRNTWSWGNTEKAKPSLRQIDDFTIEVDHHDFGKRFLSFAPSPGFSENEEDIEPVLLFTENETNMKALYDQPNTAKYVKDAFHELVVDDKEGVVNPENKGTKACAWFKFNSVPAGDYVTLRYKLSKKLEDIDEFEFDNVFSKRQDEADAFYWKISPLPMSDELRQVQRQAFAGLLWTKQFYHFVHDYWSRGDPTTPKPPPNRANGRNKDWRHLYINDILSLPDKWEYPFFAAWDTAFHCIPFAMIDPDFAKKQLDLLTREWYMHPNGQIPAYEWNFSDVNPPVHAWAAFRIYKIERKMYGREDVDFLETLFQKLLINFTWWVNRKDKDGNNVFEGGFLGLDNIGIFNRSEPLPTGGNLEQADSTGWMAFFSLQMLNIALELAKTKPIYENIASKFFEHFILIADAMTYRADDEEVSLWHDEDKFYYDAITYGGSNSQLLPVRSLVGLIPLYASLTLEPELLDKFPSFKKRLNWFINHRKKVAERNIASMETRGVGERLLLALVDKERLVNILERMLDEDEFLSNFGIRSLSKYHEKHPFEMNVNGEVYKVEYLSGESDSGMFGGNSNWRGPIWFPVNFLLVEALQRFYLYYGPDLKVECPKGSGDYLNLAQCAQEIQFRMINLFMPDQDGNRPCNGDCDLLNKDPLFKDCVPFFEYFDGDTGRGLGASHQCGWTALIAKWIHDNGTGYKTPRTPRSVGTPRRQSIYNEMACDNLDNENKSEKHEPPRTMDDLDSNNIEQYFPKSGPFPGKLLRRRSGKSLLNLTMHSLDLDEDEEKTKARLLRTKSILNYNEMVQNEMSSLTPTRSAASAQSGSSIPNSAIDDNYLNSIKSAYHQYQNRGDDYDADEFEARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE81</accession>
    <name>G3BE81_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116533</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE81"/>
    <dbReference type="STRING" id="590646.G3BE81"/>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_0_2_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="177" mass="19320" checksum="555BD1064108FAAA" modified="2011-11-16" version="1">MLRLKHTVSSGLLPIFRLRMDIARAGLSHNYWTSVGHGSSSSIRGFHTSIPKLHGHVHKAKPGEELHVTFITKDGKQIEVEAAAGDNLMDIAQAHGLDVEGACGGSCACSTCHMIVDPEFYDDIPEPSDDENDMLDLAFGLTETSRLGCQIHMTPELDGVRIALPAMTRNLQIKDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEI4</accession>
    <name>G3BEI4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_110909</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEI4"/>
    <dbReference type="STRING" id="590646.G3BEI4"/>
    <dbReference type="GeneID" id="18246232"/>
    <dbReference type="KEGG" id="cten:18246232"/>
    <dbReference type="eggNOG" id="KOG3361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_5_0_1"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="193" mass="20247" checksum="157D21EEC7C3D5B0" modified="2011-11-16" version="1">MFSRSLLKTTTAAVARSSGGAYGLSAAAAGVSASRFAARLPQFTVPSSTRFYHDNVLDHYNNPRNVGTLNKNDADVGTGLVGAPACGDVMRLQIKVDEETGIIEDVKFKTFGCGSAIASSSYVTELIKGKSLDEALKIKNTAIAKELSLPPVKLHCSMLAEDAIKSAVKDYRSKRTAVKPTLGPDAVAAPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEK2</accession>
    <name>G3BEK2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Catalase</fullName>
            <ecNumber evidence="12">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_116645</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 13">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="12"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEK2"/>
    <dbReference type="STRING" id="590646.G3BEK2"/>
    <dbReference type="GeneID" id="18248384"/>
    <dbReference type="KEGG" id="cten:18248384"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="6"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="486" mass="55056" checksum="1EBD5079487AEFC8" modified="2011-11-16" version="1">MAPVFTNSNGCPIPDPFATQRVGKHGPLLLQDFNLIDSLAHFDRERIPERVVHAKGSGAYGEFEVTDDITDVCGAAFLDTIGKKTRVFTRFSTVGGELGSADTARDPRGFATKFYTEEGNLDLVYNNTPIFFIRDPSKFPHFIHTQKRNPQTHLKDANMFWDYLTSNQEATHQVMFLFSDRGTPASYREMNGYSGHTYKWSNKKGEWFYVQVHFISDQGIKTLSNEEAGALAGSNPDYAQEDLFKNIAAGNGPSWTCYVQTMTQEQAKQAPFSVFDLTKVWPHKDYPMRRFGKFTLNENPKNYFAEVEQAAFSPAHTVPYMEPSADPVLQSRLFSYADTHRHRLGVNYTQIPVNCPVTGAVFNPHMRDGTMNVNGNLGEHPNYLDTSKPLEFKQFGLQEEQEVWEGAACPFHWKCEDDKDFTQATALWHVLAKYPNQQAHLAHNVAVHVCAADAHIQDRVFEMFGKVHPDLANLIKKETLELAPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEY2</accession>
    <name>G3BEY2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_111405</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689177.1">
        <property type="nucleotide sequence ID" value="XM_006689114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEY2"/>
    <dbReference type="STRING" id="590646.G3BEY2"/>
    <dbReference type="GeneID" id="18246275"/>
    <dbReference type="KEGG" id="cten:18246275"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102602_3_1_1"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF95">
        <property type="entry name" value="CYTOCHROME B5 TYPE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV59963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="157" mass="18558" checksum="FF117A86885C1B0D" modified="2011-11-16" version="1">MSRPSYTCEQVKAHCQPKDLWMIVYNKVYDLTNFIELHPGGIEVMIDCGGVDATEAFDDVAHSDYALDMLQPYFVGDLVPWEHRPYKTARAQFQEADKRKEQLKRERATLARQRKKNKLWKRRVERITLVVLSMVAFGTVLFYFLLQRMKLNYYSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFE6</accession>
    <name>G3BFE6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_116726</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFE6"/>
    <dbReference type="STRING" id="590646.G3BFE6"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_683550_0_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="343"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="390" mass="45408" checksum="7F8C8B0A59684A7C" modified="2011-11-16" version="1">MTSTRWKYRSSAIGALMAVSAYTNPYLRNYGLQVKTNHADVGSAVSRYWQALVHNLSSFKLVNFCLLMFFVLFNLVKWTLFGKLSDNEVSHLRDKISYTIWEFWFGFLIFLREANQIQTLDPLNTVVRHEFVKYSGFFLCIVLLKSFHVICAERAYTLSNQSHPTSTDLVQYRRLGYGVLMINFIDILLICSFFHQMYYTYCGNSILRFKDNILVAIFGFEILHSFPLVFFTGIKYTLDYYGKITFFDSESNTLTNYADWQVKKAKIISLVEFSVNLIRFGMSCTFAILFLYFYTFPFHILPSSYLSLRLLIVKARCLISLERRNIKLKKLNLPTTIDPTARCIICFDNLNSSSVDGVRCLNSCEHNFHYSCLKSWLECSDNCPVCRTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFI7</accession>
    <name>G3BFI7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116755</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690443.1">
        <property type="nucleotide sequence ID" value="XM_006690380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFI7"/>
    <dbReference type="STRING" id="590646.G3BFI7"/>
    <dbReference type="GeneID" id="18248434"/>
    <dbReference type="KEGG" id="cten:18248434"/>
    <dbReference type="eggNOG" id="ENOG502QRFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_1_1"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25300" checksum="527E5CD156F11C61" modified="2011-11-16" version="1">MTVDSTSYESVKHLPFAGNQFPAVVTEPIMFNLAKNGQPVTLLCINDASQVPPSLMRVLYREFKYIVDEGLTYPHHVTMDYQGFQEYWFHHFVGVLVEGHYASVQELPIEESEQFWDERYLGDFYVKPNYIGRCSHVCNAGFKTHHGKRGLGLGKELGRKYLEVAPQLGYKYSVFNLVFETNKASLKIWDDLGFERIGYVKNAAVLKGHDGFVGAVMFGKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFJ5</accession>
    <name>G3BFJ5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_128215</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFJ5"/>
    <dbReference type="STRING" id="590646.G3BFJ5"/>
    <dbReference type="GeneID" id="18249288"/>
    <dbReference type="KEGG" id="cten:18249288"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047845_1_1_1"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14528">
        <property type="entry name" value="PFA-DSP_Siw14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000024">
        <property type="entry name" value="probable tyrosine-protein phosphatase At1g05000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="90"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="250" mass="28744" checksum="48C887B1DBE1601C" modified="2011-11-16" version="1">MGDFSEDPFQMDDDFSASLHIASSYSDPIDNFTAATDQAQIRSRLAVLDLEQFPEDADDAFDEGEHKKATEMAQASLVNQPNHPLTPPENFAPVVNNIYRSSFPQTTNFSFLERLKLKSILCLIPEDYPDTHHQFLKNQDIKLFQLGLSGNKEPFVVISHELITEALKIVLDPANQPILIHCNRGKHRTGCVVGILRRLQQWSLTIIFDEYRRFAAPKERPMDQQFIELYNQTEIVSFCQERNYLPLSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFR0</accession>
    <name>G3BFR0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_128231</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
            <topology evidence="7">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689926.1">
        <property type="nucleotide sequence ID" value="XM_006689863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFR0"/>
    <dbReference type="STRING" id="590646.G3BFR0"/>
    <dbReference type="GeneID" id="18249290"/>
    <dbReference type="KEGG" id="cten:18249290"/>
    <dbReference type="eggNOG" id="ENOG502QRZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_2_0_1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF10">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005131611" description="1,3-beta-glucanosyltransferase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="9">
        <location>
            <begin position="385"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="550" mass="62164" checksum="9130B6732B28DF78" modified="2011-11-16" version="1">MQFFIIFIYLSLGVVLASKRSGSSSPKDISTIKVIGNKFVNEKGYQFYIKGIAYQKSREQGDNFQISDGVGYIDPLANSQTCLRDLEYLEKLNINVVRVYHIDPNKNHDACMNAFATKGIYVLCDLPEPETSINRNNPAWDIDLYDRYSAVIDSMHNYKNVLGFIAGNEVTNTIANVDASPFVKAAIRDAKKYIHSKGYRKIPVGYTANDDSRIRTDLSNYFVCGDEEWAKADFFGLNMYEWCGYSTYTTSGYRDRTLEYLNFQTPIFFSEFGCNTINPRPFTEIEALYGLTMSKVWSGGIAYEYFQHERNYGVVQENPDGSVTALEDFYTLSMRFGTNSPKIIKVTNETTPINSECLQSKYWHGSEKLPQTPDRGKCECLQSTLSCIMTPFQEVKEQELLNEVCTKVDCSEITANGELGKYGALSDCSLNQRVSFSLNKFYKQNGSKESECSFDKRAVLVSNNDQYDIKTITVRDGRTCEEALEGVKDLTNPNKDIYEKHLKEMPNGEFGFSKEPGNHTDTTSSNGSSGNSIGHLVASIMLFLVLKYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW12</accession>
    <name>G3AW12_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_91588</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683682.1">
        <property type="nucleotide sequence ID" value="XM_006683619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW12"/>
    <dbReference type="GeneID" id="18250092"/>
    <dbReference type="KEGG" id="cten:18250092"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679713_0_0_1"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="405" mass="45263" checksum="5C393FEE51057C82" modified="2011-11-16" version="1">MSGVNLQGSEALPSFSKIMENAMSNKFNPQIPATHQSCIKAPFLPDSQSRVSFSNSYVPDSQPPTNMVMNTYSLKPACHSSWSRGSNDFTYYASSPYHHTPNSSVGSYPVNYQFPPPPLIHHRPYETGADVDEVKADDVMRDITKLMSTSQDVSENMELLKREYHALLYSKLVNSPANDNASLALGSEIRPTNRITLDSIKHMLLSVPPSVLVTLEFYSQEHHRILANLKASQAKLLTQREREQLHAANSVVKSDTGRASAGSNANATQPVITYQKRKSMSSFKNSSGLSEFKPGLRRNSKSEEHVHQESKAVHHSKSKSVQKMHTSHRSVFKFPELESQSPLICTHCGSEKTPEWRRGPDGDKTLCNACGIFYSKLIRKYNSPKEAASIMKQRKSEGLEIDRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW31</accession>
    <name>G3AW31_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_112173</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW31"/>
    <dbReference type="STRING" id="590646.G3AW31"/>
    <dbReference type="eggNOG" id="ENOG502QTIR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034559_0_0_1"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF2">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="520" mass="57489" checksum="29876A3A49A66024" modified="2011-11-16" version="1">MSSDTRERNSLKTPSLHETISEVAPNSDSIWSKKKIYRSWLLLCYATGPVASMSRTYVPAAIQSIATLVGRTSQGGVCARRGNDCYVKFGTSWVHSTSYVLYLKAISTAVEGVIAILFMGIADYSNYRKILLCGSILFYGLIALPFAGLTDKTYATMTGLSVLYALLNVTDCVYQITEGSYIPLFMRASSPKGETSEEVRRNIILKRGSTVSVMGIVLGNCGGLTALLIGIIISYGRGGPIANGYHNFLLAITIAGCLTVVFSIISAYFIPSVQAKPKPKGEFLLFLSIKRCISLLKNITKYPQAFIYCISWVIWNVSYSNFLSVFVLLFRSTLGIGSSDAEYTVYTFISYIVASLGSLGWMFLYPRTKITIKQWGYGFFFVQVFSNFWGTLGINSKVKIGFKHRWEFWVFEVLFNASGSSLRSMNRAVYSTLLPEGDEAQYFGLEIMLGIATGWIGSLVNATIQDRTNNDRFPFLPNMFLALIALGLYSICDTEKGMRDVEKLVDGDSGSGYDSIESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW79</accession>
    <name>G3AW79_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease III homolog</fullName>
            <ecNumber evidence="8">3.2.2.-</ecNumber>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="8">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NTG1</name>
        <name evidence="10" type="ORF">CANTEDRAFT_128882</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="8"/>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW79"/>
    <dbReference type="STRING" id="590646.G3AW79"/>
    <dbReference type="GeneID" id="18249347"/>
    <dbReference type="KEGG" id="cten:18249347"/>
    <dbReference type="eggNOG" id="KOG1921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="9">
        <location>
            <begin position="63"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="276" mass="31167" checksum="D40C2C7CCB33FBAB" modified="2011-11-16" version="1">MDSAAKFPPRWVDIYNEVVEMRAKITAPVDLMGCERIPDGMTPKLSVNDPRTFRFQLLISLMLSSQTKDEVLDDAMRKLNNGLKSRGFQQGLSLESVMTLSDKELDGYIGKVGFHNRKTVYIKNACIMLQEQFGGDIPNTIEQIVKLPGVGPKMGYLLLQRGWNISTGIGVDVHLHRLAMMWGWSKKTTNPDMTRKYLEEWLPRKFWAEINPLLVGFGQVICTPQFQNCDVCSLATKSLCKSVNRKLVNKGLTEERLEKLKKGRGDLAQLLVSMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWF9</accession>
    <name>G3AWF9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112251</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWF9"/>
    <dbReference type="HOGENOM" id="CLU_3087047_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="52" mass="5824" checksum="2064601DD558E3DC" modified="2011-11-16" version="1">MGKSRKPLSAIRMRAILEPTVFPLFQVGSLMRSSRRTGHENDTTPGSITTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWJ4</accession>
    <name>G3AWJ4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_101177</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWJ4"/>
    <dbReference type="STRING" id="590646.G3AWJ4"/>
    <dbReference type="GeneID" id="18245445"/>
    <dbReference type="KEGG" id="cten:18245445"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="139"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="661" mass="74733" checksum="69411F96E8E01C4C" modified="2011-11-16" version="1">MSVFTSIDAKDVSKNLPLMDINMAVETNGAYHNRFSETMFQNLHPQLNTYNELFNNAVTMFSNRPCLAYRPYNPVFQTYPSSYKTLSYTQVQRARCYLGSGILYALYKNQFKYSEVHNKIDNHLENWANFGATDHSFILTIYSDNRYEWILTDLACVGYSITNTALYDTLGESSTEYILNVTKSPVVVCSADKIKKLKKLKSSGKAPELICIICMDNNVKSYTDYDLKLEVFSFQDIISLGKSHKLNQMPPTVNTIYTISFTSGTTSNPKGVILKNEQAVAANTFLSTTMKRVNKGKTLVFLPLAHIYERQTSAYALSCGYMLGFPKSKKSSDVLRDLIEDLKIYRPDYVSLVPRILNKLQSEVKSYLEKVDDFKLNQIIEQKIMNQKSFDGNKASTSNDFYPPYVKLRKRFGLEYVDWINTASAPANPATLEFLRASMNIGVRQLYGATETFGAISTTSEYDTSINSSGIISICTQFKLGENNELLVRGATVTPGYFEDPEETAKAFQDGWYSTGDVATVGKKGEITIIDRAKNFFKMSQGEYVSPERLENIYVSCNTEIESIFIHGKPTESFLIGFLSLKDDNKIPKTRKEKIELLKRINGSVQGINRLEKIQNVHVGTKLLADILTPTFKLKRKDAIVKFSELIDALYEEGPLLSSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWR6</accession>
    <name>G3AWR6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rxt3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112315</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683854.1">
        <property type="nucleotide sequence ID" value="XM_006683791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWR6"/>
    <dbReference type="STRING" id="590646.G3AWR6"/>
    <dbReference type="GeneID" id="18246465"/>
    <dbReference type="KEGG" id="cten:18246465"/>
    <dbReference type="eggNOG" id="ENOG502QX51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599906_0_0_1"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="456" mass="51655" checksum="97C3E74E0345E75B" modified="2011-11-16" version="1">MSDNPPLEERNISLPQSTTEIVPEIDDGHDSKRVKRESPQPGETSKIVTLPVAVETAAVPVFSSKDPDTPAVSVPPSTTEPTITTESTSSTQQEVENNQENPAVEPSETTAPVEVVAAENGDSPKQEKTISEETPLAGAEEPAKDAAETSTTVVAQEDEFDVSRLKPLKTKDQIIELIKCFFPNRRHLGSLVYNPTTTWLTLQTSQLTGLKDEHFEKFEDLRESYREKLKDEHYANSIKYIPMIPPLPMDYINYLLEVKIPSRFVKSFVQGLETGDVANKREIWGGKHGIYTDDSNILTMLAHLGFFEENGKLDLTGWNPKWSPSDVIFPRINQENHIKGDLSVTLMLLPTLSEYKSVYAHGINTRTWNKLNKHSGLSMAVYNIKWEIDGSYLRDKSFFKRYQTEVAYDLKYLKQSEEAGDGWTFDVKYYHQLKEKYKNMETEKNTDTKVPEPVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX04</accession>
    <name>G3AX04_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_112374</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX04"/>
    <dbReference type="STRING" id="590646.G3AX04"/>
    <dbReference type="GeneID" id="18246499"/>
    <dbReference type="KEGG" id="cten:18246499"/>
    <dbReference type="eggNOG" id="KOG3873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034001_5_0_1"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="9"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="419" mass="47401" checksum="AEFA58D2DDD11CA7" modified="2011-11-16" version="1">MEPNSIKLLTFNVWGLKYVSKFRKERIAGIVHKLRDPSEDYDVIALQEVWCEEDWQLIDHQLADLYPYRRRFKSGILTGPGLAILSKIPIKESWLYRFPVNGFPSAVHRGDWYVGKSLSVTTLAYNIVVLNSHMHAPYGYTGPNSYTCSRSCQAWDISKLINLLNKAGYHIILVGDLNSKPGSLPNKLFTQQTNLQDSWELFKSSSGQLLTNEEVSVLSPKDQILKGGVTCDSQLNSWRAKRRLDEACRLDYALINQSLGVVDASVKFVDSLPEVGCSYSDHFAYYVELKLGPKAEPQSSIDASKGDVWAVYKEFLAEIEVYKTQILPSHFKWREYHFYVSIVAILVLIVVNSMSFGPWTTVISVLLPIVSITGVINGMFALLWMRSELRNVGEVQLEVEDTLRALDTHDLIDLEVVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX76</accession>
    <name>G3AX76_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_129061</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX76"/>
    <dbReference type="STRING" id="590646.G3AX76"/>
    <dbReference type="GeneID" id="18249359"/>
    <dbReference type="KEGG" id="cten:18249359"/>
    <dbReference type="eggNOG" id="KOG3745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008002_1_0_1"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="177"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="814" mass="93816" checksum="1DB5A4185B06DB7D" modified="2011-11-16" version="1">MSFSIYNLDEEIKELLNLDDFLGGFTVNEFVEELSKDHFLKGAEVNNLEYLDPKPYIRTFESTLRELKSLSVEADSQKDQLDKQVNEYELKHSQNVLELSDRIESITNQFGNLDVRISDVSGQIDPLNTSLNKITNSRDMSIETIFLIRTYHGFFTKSKYDPLENLRVSKVYDDRLKCAKTVNNLMTLAKKIESADIPQTTQCVQAIQKFSETMERTLLNKFEVALDNDEFEVMKEISSILNEYNGGTNVIQTFVNKNDFLEEMNDDNNGAGSILDDEAVWFNLSNPDYLESVVDENLEDLLNHLKVTIKGQARIVSQVFENSTPVLKIFIQRIYAQSIQTKVNSYLQYSISVSSLAHVRVLQYLSQVVNEFTKDLKDFFITNDFDNDNELSSILDQCFYDLFIEYTSDNVYFNREKKSLEDLIYDVVSKFTSYNERALNANQLSTTLDNLNNLDYNNDSTASSDKAFGIIERKRLNKFKDFMKSRLSEVNVRNRNSIDPEDSEERKQYSSLNLALAETIIKSIIESVARVLELEPNRSPEYALELLEILLFDFGKLYIQGSLEVIYDALKSESNYTKVSSNNAIDFSYLQSFTLLTDILFLLSSCIRRVIIPCSANNPNIRNRMINLTNSYIKRCEVAINVILKETMDLISEKLAYFLSKQKRKDFLADNITEYDTEACEFVSDFMTKTHESLTVSLHDSNLLNVLTKVGMKFLSLLLEHFKKFTVNSTGGIILTRDVIRYQAVIESWEIPELSENFQILKEIGNIFTVHPNLINSLVTEGQLASLKPSTIRQYVAKRTDFNPSYLERFFSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXI0</accession>
    <name>G3AXI0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_91548</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXI0"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="83"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="514" mass="58854" checksum="21E14E0D2A5FC5E1" modified="2011-11-16" version="1">MAAEKTLDAISVHSSVQENEPENTNSLDLKEQFEVKEDEYSVSIKVSEEEEAYRKSWKFLIWDTWGHPNKAHVKVIRKVDLTLLAFATVSTFIKYIDKSNLTAAYVSGMQEDLKIFGNELNYANTAYNIACILCGYPFGYLMARFSTRWLIIFVEVAWIIITFSFSSIQTPLQMIVLRCLLGIFECAHYPALSFLLGTYYTPAEFARRNVILQSATALGSMFASYIQSGAYTHLNGVLGRSGWRWVFIIDGIISVGVLIPQIVFFPDILARNKPSFVFSEEDLQYLKERKPETKYQTFHFGWEDVKKVFTTWEVWAFWSYGMSQDIVSLSMPSFIFWLKAYNVKKPGTYSIPQVNNFNSILYAVQYLVAVGTGWWSDTALKGRRWPPIVLAGVISFVVMILLASTPVYPDNKGFRFFLYLNTCWALGTAGIYWAHVQEYFKDDIRLRAITTGGINIYSFTADSIINPIWFKTQEQPNVRTGHYISAFFAVVYAAVGGLLGWKEHTLRRKRLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXS5</accession>
    <name>G3AXS5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_118199</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXS5"/>
    <dbReference type="STRING" id="590646.G3AXS5"/>
    <dbReference type="GeneID" id="18248625"/>
    <dbReference type="KEGG" id="cten:18248625"/>
    <dbReference type="eggNOG" id="KOG0948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="150"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="387"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1063" mass="120266" checksum="9CF4694E0C01F503" modified="2011-11-16" version="1">MDDLFDVFDEAPVEVPEPPIAPVNNPDTVKNTAEVVEPQEDSESQKRKLADDSASHKLKKQTTRKPSIKAVVSDALEIEASREVAISDGLLASKPDPNGHPSGQLKLKHQVRHQVAIPPGFPYVPISEHKRQNDARRYPFKLDPFQDTSISCIDRNESVLVSAHTSAGKTVVAEYAIAQSLRDKQRVIYTSPIKALSNQKYRELQAEFGDVGLMTGDVTINPDAGCLVMTTEILRSMLYRGSEVMREVAWVIFDEVHYMRDKSRGVVWEETMILLPDKVHYVFLSATIPNAMEFAEWIVKIHEQPCHVVYTDFRPTPLQHYLFPAGGDGIHLVVDEKGTFREENFQKAMAQISDGMGEDPGAVDGKKGKKGQTWKGGNNDGKTDIYKIVKMIYMKRYNPVIVFSFSKRDCETLALKMSRLDFNNDDERDALTKIFNNAIGLLPESDRELPQIKNILPLLRRGIGIHHSGLLPILKEIIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTSVRKWDGVGFRWVSGGEYIQMSGRAGRRGLDDRGIVIMMIDEKMEPQVAKGMVKGQADRLDSAFHLGYNMLLNLMRVEGISPEFMLESSFFQFQSASSVPKMESQLVELTNQLSTINIDDENLIKEYYEFKVQLSKLQEDSQKIITHPGHILPYLQSGRVIKVKIGDMDYGWGMVQSFSKRANKRNSSAIYSDHESYLVQVFIYSLFVDSPVNLIKSFNPDLPEGIRPSKSGEQSRAEYIPITLSSIEKISSVRLKVPADFKSSSAKRNLLKTLKDLPKKLPDGIPIMDPVNSMKIDDDEFKTLLRKIDVVESKLLGNPLHGSVRLDELYQKYDSKVKIETQIKALKDQILETKAVIQLDDLKHRKRVLRRLGFTTQNDIIELKGRVACEISTGDELLLTELIFNGTFNDLTPEQCAALLSCCVFQEKAKETPRLKPELAEPLKNLQEMALKIAKISKECKIEMVEKDYIESFRPELMEVTYAWCKNATFTQICKMTDVYEGSIIRTFKRLEEMIRQMVSAAKTIGNMELETKMDKALELVHRDIVSAGSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY27</accession>
    <name>G3AY27_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_92083</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AY27"/>
    <dbReference type="GeneID" id="18250154"/>
    <dbReference type="KEGG" id="cten:18250154"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000972_1_0_1"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12206">
        <property type="entry name" value="RasGAP_IQGAP_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="158"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="975"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="795"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1578" mass="181724" checksum="D0C810575980A62D" modified="2011-11-16" version="1">MSSPVKNIALKYLDSINDINDDISLRSPSKVPLQPSLRQNTKPTFNKSFPEEDLDKLARQLDVDPVSTPTKNALFRTKYQTPSVTVSSFKTPTTKSSTSSSKSGSPIKRHLAAFETPIKRSTEIPALKTDMTLSSKDKPYLSSPGNSTSTDSPGYEYLCRIEAIKNWLQQVMGEPIDKSAAEMISDIRNGIVLAKLANVILPTRKSVFTNPKLQFRHTENINRFFKLMDFLSVPDIFTFELTDLYDAKNVPKVWFCLHAMSYMLHKYNPEFPQIKSLVGRCEFCPEDIRTANRALVGAGLPNFSSADNNNDSTFDSIYMNRVINNSPTKLNVSSTFSRPSDTLSSPKKSDKFSDDPFNDKTSFRQPRTPDRSSPASARDEFYTPKSHSIRESMSDDVDYKDSRYYTPEIDDHLINIVKLQALSRGATFRYRMFVSKIMLRSYVDEFTHFNSIIRGNMARMRTIHRHRDEVLLFKHQIIDFQAISRSKLLRSKLTYDFNQHTDNVVRFQSIVRGSIVRQHVKSIKYNISMAEPSIIELQAQSKMLLVYPKVMTVLEQKALIEPSVVDFQSVARRLLYQRGKIVDLISNLKDCGGLINFQAVIRAKNLRNDFYGRIYVLQKVESKLTQLQSVARGGTVRTKLCNNVLITLMHEDVQMNSLFAKARGNMTRRSIGYTNAYLHHYEDEVVELQSRFRGLFMRFKRDVVLEDCYNNIGDIIALQSIIRGNVIRKEMNSIDSYYVKNMASVIKVQSHIKSNFAKRAYQSLITMRNPPLSIIRRFAYLLSDNDTDFEQELELAELKDRIIERSKANEELETLIENLDIKLGLLDKNKISIEDFIKNKFNHFKDIDEDVNIKNLEKLNKSSRERIECYQTLFYFLQTKPIYFVRLHESMELSIKETKEFKNLQKFIVLMYPIKDSSISHHSREEFFFMKLILSLMESDMKTHCSNLTDITKSSCCFWIDYFVHFNSHTYQRLHLKTMLGKTVMSVIDNDDLDFESDPSVINASLIDRDMRINGFSDRDVDASPQIAIKDPEVSNKFVENLMNLREYITSTLNILEAIVDKIPLHIRVVCSQAYKLSKLTYPDRSEMQHLAVAGVIFIKHYIQNIFQNPENFGFLANNSYNPGILKVKCKANLKALGRVMMQAFALKPFSDNFLKPLNEYLQSSVDLTRSIIVRLINVDDLETSYNLTDYDDIVTHDRPKLTMKVTDMAQIEKIIQNNIDMVAPSSDDQLYSVATQLNQAVNTAKDLVALTELGSLTLNLNPTTKEESIADTKGNALFTQVKRSVLYIIRVQEGDELLELLVAGITPDHERNFKEITHGERQVSQEANSGQKKKAYHKTSLGDLTKITYHDLKKNALETILQLEFMGLVHRNNSYQEILNQIAVDIKTKHSQRISRKSQLEIAIKTQEKLIEKERVLNRQHRDYNNHVESILSQLQSRPKDKKLFNIIPIFSKQYFYHRELKKSNRLPKFGSYKYSARKLIEQKVILDFAGALSARYNTSSKLDFMFSCHRVGIFTIEAASGSVSIPGAFASITLDELLNLQYESKDKYEVFDGMVVFDTMNLTSFVFKKFYDMKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY63</accession>
    <name>G3AY63_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_96872</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY63"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070889_2_0_1"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="66"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="190" mass="21477" checksum="953FE10B3DEBC161" modified="2011-11-16" version="1">MSKGHRKVDEEESFGLSDIARIIAGLLLVNCILSYAFTSSTTWGYEGRWIDPHYVNWKLTGNYVNLTLEQLSQYDGSNSRLPIYIGINGKVYDVTRSSSVYGPKGPYGFFSGKDGARAFSTGCFNKPDEFTYDLRGLDLEVALKDIANWQKFFENSDKYWYVGTVIHEPITGDPPAPCHHVKFPGYKKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY96</accession>
    <name>G3AY96_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_118501</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY96"/>
    <dbReference type="STRING" id="590646.G3AY96"/>
    <dbReference type="GeneID" id="18248646"/>
    <dbReference type="KEGG" id="cten:18248646"/>
    <dbReference type="eggNOG" id="KOG2750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010345_1_1_1"/>
    <dbReference type="OrthoDB" id="4054781at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="8">
        <location>
            <begin position="226"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="614" mass="70075" checksum="B49AADFE8C5CED77" modified="2011-11-16" version="1">MSAYAALREGSIFGEDEEVVIKYDNSSDEEQGIPETILAEVAVPEGGSPSTTFIADEKNLVYSSKHMVVGLKVNESVALSGQFKLVIERGAVLINGIHYYHAPQEFIVIQPNISSLPTISSTQIINSSEVRDLPSDENEHLFCSDYKSVVRLENISTGLENIAKYYQPFKNLFSLPEDKQDLPLQNYTFDILTNNEASIRYDRGLVVEIEGLIDGIEEVSSFITIGNKNSGKSTISKLLLNTLVESSPISILDLDPGQSEYSKPYCLSLTNHFDPIIGFNYHKNENDLHYFYGFTTPQGNPELYLKITKSLIEHYQKNLKPKGHHLIINTPGWVKGYGKELLTEITEWVQPDHLILLSANKLDNEETLSNLVFKNLRIWKGYFVQNRYSAAEVRNFNKLVYFHKTKPLQYNFIDHLLDSSPLKISYQTGEDSSFVGVNVVSILNHDMGLNFDIEDIVLMLDTSIVGLYVIENEYFEAHKQIITYTKNRLPYLSSSKFSDLIEYNTPHVKFMGSGIIHSINVIENFFNLYLSQSEDLETIKKLMLQGYKLLVVKGESDIPKSEILMTELLEEFKRRYKQSFKSKGPLPTFPYVSYNNKINGVWKIRRNIMRRGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYE8</accession>
    <name>G3AYE8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112698</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684777.1">
        <property type="nucleotide sequence ID" value="XM_006684714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYE8"/>
    <dbReference type="STRING" id="590646.G3AYE8"/>
    <dbReference type="GeneID" id="18246643"/>
    <dbReference type="KEGG" id="cten:18246643"/>
    <dbReference type="eggNOG" id="ENOG502QS34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046574_1_0_1"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="146"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="400" mass="44659" checksum="ABA6311B3EF3416E" modified="2011-11-16" version="1">MPSTENKSSSISITPLPKHKFGCKIQLPEYCNNDPINLNDNDFNQLFEAVHKYLVVVIPGLAELKPKSQYLLTKKFDPTIPEPKGEGFGGYGHGKEFRHEQSVLRKDGTSVKSQPQVQILGQGTFTAGEPGNENGEDISLTHPSHTSFHKDVLTPDEIKHEHKTRFYRWHIDSALYELSPPVVTTLLGIKVPPATQTNTITYGRDSDDQLEVAQGATCFVSGAEAFRLLSDEQKEYALNTTIEYAPHPYIFISPARATSDGLTMVSEGKETPFDELPAWEEQKVKKLPMVWTNPVTKQHHLQIHGCCLFKLHTKKSDGSVSILDLEDSRKKVHSLMRPAIAPQNVLAHAWGEGDLVIFFNRGVWHSVTGEFKGVKSDGQDERRLMHQCNIASGVDPKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYF6</accession>
    <name>G3AYF6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_96933</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
            <location evidence="1 15">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYF6"/>
    <dbReference type="STRING" id="590646.G3AYF6"/>
    <dbReference type="GeneID" id="18250641"/>
    <dbReference type="KEGG" id="cten:18250641"/>
    <dbReference type="eggNOG" id="KOG3430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070944_4_0_1"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 15" id="KW-0243">Dynein</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV65842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="90" mass="10268" checksum="F9D61EDB9384A99F" modified="2011-11-16" version="1">MSEKQTPVLRVADLPDEIQTKVFELASEATDNYKVEKEIAAYMKKEMDQLYGPSWHVIVGESFGSYVTHDQGCFTYFYLGELAFLVFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYZ9</accession>
    <name>G3AYZ9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_133402</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYZ9"/>
    <dbReference type="GeneID" id="18249701"/>
    <dbReference type="KEGG" id="cten:18249701"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007571_0_0_1"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF28">
        <property type="entry name" value="REGULATORY PROTEIN ADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1128" mass="128186" checksum="45BE6A51B88BFC8D" modified="2011-11-16" version="1">MISLNYKNMEPNFANVTSSFSNSSDISAPGTASKPSASPSHVTKRSSRNSSISSSADDSPQVDGNSKKKIPLELTAYGTTPSGKPRLFVCQICTRAFARLEHLRRHERSHTKEKPFTCGVCQRKFSRRDLLLRHAQKLHAGCADAITRLRRKSVKKAGDIDGPTSPTKSDSMPTPDKLDKSSDDHGDHDINFNLNLFGSDPIHSQLQQMQQMTHSHSRSQSLSSAPNTSSSKIVSPPGQNHVFKKSRKNSDLSKHLFFRGRGASFSAQSGQNYAANVPEFNELYTGAENVEFSTPQLAPSQNYDESSWLNSLSSIPGMNSSELKDKKFDLNNMHYMMPTVTMQNDFGKHGISNGNLESGNSTRNGDDDDKEIYGYSFYDIPESMMTTNFNSEFKLNTMLTPIKQEFEEDHLNSSSNSNSNSNPNSRSHSQMAFHGHSQRQPNSGKQNSKPPSVDQFDLNFIHDIGDLTNEIDVSSKFMPNGYSFYGDNPSITSSNIDSPSYNSPNNYLNQSQLLNIENTTNFNNLKLTSYAKNRMYTANLRNMINKSLSKYPINGISNPIIPSNEKLEFYLEFFINTFLLHFPFIHPSKLNEYEIMMMTSNEDYSNESSRACLPLLTATIGALLSNSKSDSEHLYEASRRTIHIYLETRKTKQETKNNNPLWLIQSLTLSVIYGLFSDNENNVFIVIRQLNALNSLVKTSIKENVNKKHKVYFSINPQEEENLNVSKSGKSDSLFDNSVMNEELLFNNGISLQSQSRIIFMIYRLTNFLLIYYNIPLTLSINDLNNTELPNKLDEACWNCKNYQHFKETGHLNLAIDSEEKQPVLYFKDLLLKISKNSNLLNFSNNKNLSIMNDLSNYGFVTLVHGIFEINQFNSNLNTVNILNNLTVFLKDSPCSPQIQDYSVLTNFIKISSILDFKLLKQQSWLKNHNELIKQFENLLNSVKLNEFSKVDKILDYSLVSLKFLLTKCEKSITSPNKAKDRDFMDEDLDETSFENLLGVHFTDEVMVNDMNLILAQSIFHLCSLSAVLLLKYLKYPLSNYKLVLTSKFKEMLELLQHLQKGFGLTTVYHLDLQEDLSYSSILYILNMGEILLLKIHTQKLNFAIFEKLSANLAQIRKFLISYENKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZE8</accession>
    <name>G3AZE8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112938</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZE8"/>
    <dbReference type="HOGENOM" id="CLU_2800853_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="68" mass="7686" checksum="FDB128ACF32E6A3D" modified="2011-11-16" version="1" fragment="single">MTQNIVTFVITGRTGSNDINYWPDASLGVAIAKWALFMPVQFKWSAAAQRLLLRKIICASICPRKYHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZS7</accession>
    <name>G3AZS7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112969</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZS7"/>
    <dbReference type="HOGENOM" id="CLU_1277480_0_0_1"/>
    <dbReference type="OrthoDB" id="4021680at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="216" mass="24907" checksum="4ED469E1759F1551" modified="2011-11-16" version="1">MPISKVVEMTRLTSRAGVRTRKFTGVNSRFQAVLEEFNSLSCDFLTRQQAAKATVFRSVLSFIHWFKINKFNYVLHDKNNHLKQSYIEGNLEVTNSSAEVTSTGGMVARLTSTRYVRPEFRPDTYSLSPTHLLKSAIKVGKFMYSAQVLNIQSNTVESVLLALTDTRIQLEPESLLVFKDQNSHIQTFYDQKVRIYLRWHVYNDKPIDVDLLRSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B039</accession>
    <name>G3B039_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_119535</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684994.1">
        <property type="nucleotide sequence ID" value="XM_006684931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B039"/>
    <dbReference type="STRING" id="590646.G3B039"/>
    <dbReference type="GeneID" id="18248708"/>
    <dbReference type="KEGG" id="cten:18248708"/>
    <dbReference type="eggNOG" id="ENOG502QPI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000998_3_0_1"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="1">
        <location>
            <begin position="125"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="1">
        <location>
            <begin position="427"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="694" mass="79510" checksum="19E75993C830C0F2" modified="2011-11-16" version="1">MTTSPIFDKLPVSEFRNINEAKSKNVPEECPQDSPIDLNIRSGPILKLFNCNDKGSSRYLASLLLVLEDYDEVPSITYQLGDSNSQEVVGKGNFDGNCFYKHENLQFYRYMIDLPLQPHESVCSYAINGQTTAYWKFYLPASTQSMNIVSFSCNGFSLACDAAQYPSSLWFDVLNRHSQNPYHVMLGGGDQIYCDSVKVMSTKMQQWTQIDGFKKKQQMQVDEAFEQDLHNYYLHHYMAWFGKGFWVGKKSRYLDSLFPMAMATIPSINIFDDHDIIDGFGSYPEATMASPVFKAIGEIAFLYYMIFQHHQLPQERLQPQFDSSWIVGTTKPRYVPYLNRSLFTRLGPEIAVVGLDCRTERSLSKIVSDSSYKGIFGRMKSELESNPDIKHLLVMLGVPILYPRLVWLEMVLTSPWLKPLRKLAEMGVINKGLLNEFDGSIEVLDDINDHWCSKNHKAERNRLVRDLMEFGAQHSVRITILSGDVHLCCIGRLKSRVHHHPTFHPIKKDNFKQQNRNTLEFPQYDPRLMFNVTSSAIINAPPPDAMATLLDKRSKVHHFNRDCDEDVVPLFNVNPDGHPRANLQFLNKRNWCDLNLAKHSVHKNEVSHEDDERIVSRYPGSTKVAPAPSSSHNSYERFIEYPLLADSLVTTIHVEDDAKDFDCKTMGYELLIPPLMGSYELEDVVIKHVNESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B098</accession>
    <name>G3B098_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_133651</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B098"/>
    <dbReference type="HOGENOM" id="CLU_521751_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="522" mass="61645" checksum="61C339CB7386FD93" modified="2011-11-16" version="1">MWKYKEPSSTQQVHINEYLKAKLEDFPQINNKVPKNLEFDKPHQYDFDLSTKSKGTANTFTEVVQDTISLELSLPSHKVFVEEQWKYLISLMVCNRSRPLMLMNSDIFAFLQASRVPRMTLDRKRKLHEATMTNIAREMVFDLVTNISRLFFGSSLEKSDGIDFKTLLNYKMTTLHCLPDLPVLGLPRFGSIIVGEVKKPSIKHWIKQLHDCNYMIFINVSERNDSITKSLEGSLNQLIAYQIMAKCKLGYISDTIVHIFTTITDINDKVMSVKVDITISSRIYNENPEMYPPAALMLAKIAEIQRMKPKTYLDFYFDETMTTRNFQWFKKSLNHLKHTYIYYDLKTTDEIQREPGLYSQIFCIPNKYLASTFLSLDIPGEEIVVKVFDPGYYFISNWSYKYQYDDARYNIQQYFENDIEHYQKPYFAVNYENMFMDKGKFIFSHYNPPTEESEESDDTPEVESFQSQRIKEFIEVWRKKDPEYSYIIAKESVNRFEEETQREITLDNDVQNPNSMRNKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0C1</accession>
    <name>G3B0C1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymidylate synthase</fullName>
            <ecNumber evidence="4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_133667</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0C1"/>
    <dbReference type="STRING" id="590646.G3B0C1"/>
    <dbReference type="eggNOG" id="KOG0673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_1"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000005">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="12">
        <location>
            <begin position="112"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="405" mass="46090" checksum="6DC2749E5DA6C62E" modified="2011-11-16" version="1">MSDIGRKNISDKIESKITPDSQKSGFQQAKDKVTDTADDVVGGNTASDGKSWTQQASDAVFGEKKSKLSKCFCKKCWPIFIAMVLHRSHERAYLRLSLITPNMTVKANNAEQAYLDLCRRIINEGEHRPDRTGTGTKSLFAPPQLRFDLANDTFPLLTTKKVFTKGIIHELLWFIAGCTDGKKLSDLGVKIWEGNGSREYLDSLGLTQRREGDLGPVYGFQWRHFGATYTDCDADYTGQGIDQLQEIIKRLKTNPYDRRIIMSAWNPSDFSKMALPPCHVFCQFYVNFPQGGKPKLSCLMYQRSCDMGLGVPFNIASYALMTKMIAHVVDMDCGEFIHTMGDCHVYLDHVDALKEQMERTPRDFPKLVIKSDRKDEIKSIDDFRYEDFEITDYKPYPPIKMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0K5</accession>
    <name>G3B0K5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diacylglycerol pyrophosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_102628</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0K5"/>
    <dbReference type="STRING" id="590646.G3B0K5"/>
    <dbReference type="GeneID" id="18245565"/>
    <dbReference type="KEGG" id="cten:18245565"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_6_1_1"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="259" mass="29060" checksum="4832F555861A44A4" modified="2011-11-16" version="1">MSQASKEIKKYAGDWITAGVVAGVFTLYLELAPAHARQFQINDPKISHSFANPQIINDTKLYLLVFVIPVLILTIVSYLKAGTRFVKTAHLSILGLFLSFVLTGFLTDLLKIWISRPRPDFMSRCLPKEGTPLDKYVSLEVCTQTSYFLLNDGLKSCPSGHSSLSMSGALFLCLWLNGQFKLFNSNKPLWMQLSSWSYVLVALFVAISRHIDYRHHVEDILLGLLIGGSCSYYVYFRYFPALGSSESDLSLDEVSVLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0R6</accession>
    <name>G3B0R6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_119918</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685144.1">
        <property type="nucleotide sequence ID" value="XM_006685081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0R6"/>
    <dbReference type="STRING" id="590646.G3B0R6"/>
    <dbReference type="GeneID" id="18248736"/>
    <dbReference type="KEGG" id="cten:18248736"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="OrthoDB" id="4025884at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="483" mass="55053" checksum="BE79263446A0FE7A" modified="2011-11-16" version="1">MDKSQPIIIVGSGVYGLSSAYHLATAGYTNIKVFDRGDYDNNEFSPLQGADGASTDVNKLVRASYVDKVHYQDLAVEALHDYHEWNEQLLKMPFLPRALATIQERCLQEGDLEPIFQNTGYIRLDDYENGEEERNLHNFEKAGLRKHSYDINNADDITRAKITGWYRALDPLNQREKVPTLTGVLDSFAGVALADKCLIWVRYLCERTGNVQFIYGPGKGEVSNLVYSAEDSLKVVGVKTVDGKEHQATKVVLAAGGWTPKFVPESLSPRLEAMASTYIMIQIPRDRRDLINKYRRIPMINWRMTYESNFRSDAVYVFPATHDGILKMGVNDHYWRNLVKVGDEMVSIPDTNMKLLPKQSLLDYQKFIKEFMPDLYEAGASIEKTKICFSSVGQQNELVIDFVPSYKNLLVCAGGGFHGYKFLPVIGRFTEGLISGKQYSHSQFFKFDYIDPKDYKPIVKDPEHEYALNSVEFAESRSKYYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0S9</accession>
    <name>G3B0S9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_104170</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685598.1">
        <property type="nucleotide sequence ID" value="XM_006685535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0S9"/>
    <dbReference type="STRING" id="590646.G3B0S9"/>
    <dbReference type="GeneID" id="18245694"/>
    <dbReference type="KEGG" id="cten:18245694"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="262" mass="28288" checksum="5D99832756169EEF" modified="2011-11-16" version="1">MFETLLGKTVLVTGASAGIGAATATEFVKATNGNIKLILGARRVSKLEELADGLKKLYPSVQIYVGQLDVSEVSKIDQFFAQLPAQYSEIDVLINNSGKALGQEKVGDIDPTDIATVFDTNVLGLIAMTQIVLKGMKKRNRGDIVQLGSIAGRWTYAGGSIYCSSKAALKSFTEAMRKELTSTKIRVIEVAPGNTKTEFALVRFKGDADRASQVYEGVDTLLPQDVAELIVFACSRRETAVIAESIIMSTNQAGPQDLYRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0T0</accession>
    <name>G3B0T0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_134106</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685599.1">
        <property type="nucleotide sequence ID" value="XM_006685536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0T0"/>
    <dbReference type="GeneID" id="18249767"/>
    <dbReference type="KEGG" id="cten:18249767"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015712_0_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="570" mass="64546" checksum="8BACAC8FBDCB13DE" modified="2011-11-16" version="1">MTEQMAQSKSEEKSRPFACAKCNKSFTRAENLMRHRKSHLHQKYTCPECHKVYSRSDSLNLHTRKVHNFTSKPVPDVAIKSEKSPLVDIDSDRVLKYLLSYWKNFHPSFAILHCSSYSLPTDYPEDLLANVICAIGARYMENERYVSNQIFNYVFQKLDQFPKSPSLSEVQAILLASFTGIYSGGDSWFTKSFSSHSRLVNLAREMSIFQYNPLDNSDSDWMSFIETESNKRIAYGLYLVDALMAILLNYPPCLSHYEIKHTLPCPDEVWEAETAQEWLKLSSRLPAQRGPHFFEALQQVLMFGHISSPISSFGGLASLLAIHIMIRNMAQYAGILETSPVHSQDAFSRRSQLGSALNGLRTLIPKRNQTGKLSDMWDLFTVTWNLAYIHLHLPDTIITSGIVEVSLDETIATASALAKPQSKPPPGTALLSNDFTDIPYQVLSLTSSHVFYFLYTFTTELNETSPVFTFMFYKAALVAWQILNAFKSINQKSNEEILDQTVSQLTKSKTSEKVYMLKRLTDDMINCIQPENDHPVVFEKWVESVLASKDTWGVGSCGAASFASMIDDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0U5</accession>
    <name>G3B0U5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_113576</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0U5"/>
    <dbReference type="STRING" id="590646.G3B0U5"/>
    <dbReference type="MEROPS" id="T01.P02"/>
    <dbReference type="GeneID" id="18247027"/>
    <dbReference type="KEGG" id="cten:18247027"/>
    <dbReference type="eggNOG" id="KOG0180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_10_0_1"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="205" mass="22501" checksum="F7231EBD49EA6DC2" modified="2011-11-16" version="1">MSDPSSINGGSAVAMVGKDCVAIACDLRLGSQSLGLANNFEKIFTINDKVMLGLTGLATDVTTLNEVFRFKNNLYELREERKIEPQTFANLVSSTLYEKRFGPYFCGPVVAGLNKENKPFICGFDLIGCIDFAKDFIVSGTASEQLYGMCESLYEPNLEADDLFETISQALLNAADRDTMSGWGAVVYVVTKDSVTKRVLKTRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0Z3</accession>
    <name>G3B0Z3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="20">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTEDRAFT_120894</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="20"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B0Z3"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_3_0_1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 19 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1046"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1087"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1167"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1196"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="174"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="979"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="17">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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            <position position="554"/>
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        <ligand>
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            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="692"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="715"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="750"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="830"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="831"/>
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        <location>
            <position position="926"/>
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            <position position="932"/>
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            <name>ATP</name>
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        <location>
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        </ligand>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00008109"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023034"/>
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            <dbReference type="ARBA" id="ARBA00051303"/>
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    </evidence>
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            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="22">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16212"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGV64842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1306" mass="147262" checksum="F93CE783FC37F9E0" modified="2011-11-16" version="1" fragment="single">MYSPNNGARHSSNPFTDSSNLIDLDAGSSNIQDADTNPYDRVPARSESYDPFQDHFVVDDDASFEVDNTHHNGPYDASADTSARSGPLMGSTPAQKNRLLSGFRNPNANNNGYVGMENPFADTATAAKPKINDTQEASDFDIRRIFRRMKNTVTGKSHKNLEEDSHEHKPPRHIHIMSHSANSSAGYYGNYISTTKYNFATFLPKFLFEQFSKYANLFFLFTSIIQQVPDVSPTNRYTTIGTLLVVLLVSAIKEIMEDVKRNRADNELNNTKVFVLDAANGDFVAKKWIKVQVGDIVKVLNEESFPADLLLLSSSEPEGLCYIETANLDGETNLKIKQSRPETSYLVNPRFLVSDLSKAEIISEQPNSSLYTYEGNLQGFGSTRSIPMTPEQLLLRGATLRNTQWIHGVVVFTGHETKLMRNATATPIKRTDVERIINIQIIVLFCLLIVLSLISSVGNVIKTQVNRSSLSYIHLEGTNIAALFFKDILTYWILFSNLVPISLFVTVEIIKYYQAYMIGSDLDMYHEETDTPTNVRTSSLVEELGQIDYIFSDKTGTLTRNIMEFKTCTIGGRCYIEDIPEDGHVQVIDGIEIGYHTFDDLKQDLNNTSSQQSAIINEFFTLLSACHTVIPEVNEVTGEIKYQAASPDEGALVSGAASLGYKFIIRRPKSITIENTLTGIQSEYDLLNICEFNSTRKRMSAIFRCPDGVIRLFCKGADTVILERLSDIEEQPFVNATLRHMEEFAAEGLRTLCIASKIVSEDEYQAWSARYYEASTSLEDRQDKLDEVADSIEGGLFLLGATAIEDKLQDGVPETIQTLQTAGIKVWVLTGDRQETAINIGMSCKLLSEDMNLLIINEDTKQETRMNLQEKLDAILQHGGDTDNNALDSSLALIIDGHSLKFALETDLEDLFIELASRCKAVVCCRVSPLQKALVVKMVKRKKKGSLLLAIGDGANDVSMIQAAHVGVGISGMEGMQAARSADISIGQFKYLKKLLLVHGSWSYQRISNAILYSFYKNMCLYMTQFWYVFANAYSGQSIVESWTLTFYNVFFTVLPPFVLGVFDQFVNARLLDRYPQLYQLGQSRKFFNVTVFWGWIINGFYHSAVIFVCLYFIYHHGDQLSSGLVVNNWSWGTALFTTCTLTALGKAALVVTMWTKFTLVAIPGSFVLWLVFFPAYATIAPLINVSQEYRGVLNATYPSLTFWATVFCVPVLCLLRDFTWKFYKRRNNPESYHYVQEMQKYNIQDHRPRMEQFQKAIRKVRQVQRIKKQRGFAFSQVDDQNQEKIIRLYDTTKKRGVFGELSEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1D3</accession>
    <name>G3B1D3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_103297</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1D3"/>
    <dbReference type="STRING" id="590646.G3B1D3"/>
    <dbReference type="GeneID" id="18245618"/>
    <dbReference type="KEGG" id="cten:18245618"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_1_1_1"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="400"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1104" mass="122210" checksum="529BB257EE5DD61A" modified="2011-11-16" version="1">MDPQYLTSLEDTLKQTLVANTATIKQASQKLTKDFYTNPLALPSLFHILQNAQDDQLKQLASVEARKLVYTKWAGVDEGLKSQIRSAMLNNTFTQSSKLIRHSSARVVAAIAEMDLDEKKWPELLPTLIENVQSEDVQTKEMAVFTLYTILETQSSSLLDLTSDFLNLFSSLLTDVTSRSVRVNAVLAFDTLAAFLENLPSIDAQTANKFKSCIPLMVNVLREVIQADEIEMAKDIFNVFNSLIFVENKLMGNHLIDLIKLSGELAINIELDEEIRVFALQFLISSVNMRKSKVLSSNVGPDMTLIGLKVASEEIDIEEELENEEDENENEENAPPTLGLRLLAMLSAELPPSHVITPIFENIPAMLSSSDQFQRRAAILSLGVASAGSPDYIAGQINKVVPALVSGLKDPEVVVRIAALKALAELTSELQDTITAFHEQFLPLLIDIIDSATSVGVYKHACVALDGLIEFLGHDSIETYLEPLIKKLLVMLQQAHSSTLKSTIVSAIGSTAYAAGKKFIPYFNDSIQYLEPFVVAAAETEGLTEDDIELRALTFENISTMARAVGKDAFARFANPLAEAAYQALGSEHSRMRESGFAFISNIAKVYGEDFVGFLDKIVPEIFKCLEQEEFTFNLDEEDDELDDDDDLANKFNVNTGITYEKEVAAVALGELASGTGKHFYKYVEQSVKVLMEQVENSYGMREAAMSILWKIVRASFVAEHGEHFKYPKGIPKSVYINGSIHDLIKNVRSLSIENLKEEYEITMVACILGKFDEAISEFGAIAILDPTDTESLSELCGQIMEILTKKHPCQVDDDEVPNDEQEASETEVVLFDSALEVLVNLGVALGPDFGKIFNSFKEVIFQNVTSKSKTKRITAAGCLAELASVLSGDAALSQQLMEIFVNRLGNDTSIDVKANAAYGIGLIVENSDVDFTSAYNSILEMLFHLLSKTDKQATDADDEETKEVINRSYANACGCVARMALKNENAVPLQHIMTPLLSHLPLEASYEDNTPVLNLILRLYETNNELITSQTDKVVDILAKIFAKEADFKQMQETSTLGREENLDRMKQFETPELKQKVIDLLRFIEQKYAGLVSGNESLKTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1L0</accession>
    <name>G3B1L0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_103687</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685277.1">
        <property type="nucleotide sequence ID" value="XM_006685214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1L0"/>
    <dbReference type="STRING" id="590646.G3B1L0"/>
    <dbReference type="GeneID" id="18245649"/>
    <dbReference type="KEGG" id="cten:18245649"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_3_0_1"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41989" checksum="58AFDC565EB8503E" modified="2011-11-16" version="1">MVGISTNLIHNKTVSRDVIPPINISTTYKYSEDPDDLVKVTDSKGSEDYFLNDTYFYSRVNHPTSELLEKALSKILDGHVVVYNSGLAAFFAALTYINPKKLVIGQAYHGCHGITKIFSRLNGLEVLDLKDPGSFDKLQKGDLVHLETPVNPHGLDFDISYYAELAHKKGALLMVDSTFAPPPLQYPFKHGADIIMHSATKYFGGHSDLLAGILVVRDKSVQYKLYEDRVYLATNIGNLESTLLYRSLKTFELRILKQSDNCEQLVKYLNDHRAEFKVLKELFHGSLQTTKYPDQITKHSPTFALTLTSEKLAKSLPSKLNYFVHATSLGGAESLIEWRALSDSSVDPSLLRVSVGLENIDDLIEDFKNALLSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1S3</accession>
    <name>G3B1S3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CobW-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113285</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1S3"/>
    <dbReference type="STRING" id="590646.G3B1S3"/>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="8">
        <location>
            <begin position="24"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="9">
        <location>
            <begin position="312"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44100" checksum="9CBE8D26D9377417" modified="2011-11-16" version="1">MDKDIPQLSKVPSSVPTRLPKKVPITIITGYLGSGKSTLLQKIGQTSKKRLAIILNEFGDSSAIEKSVTIEDASKNEAVQEWLDLGNGCLCCTVKDNGVMAIEQLIEKSRDKIDYILLETTGIADPAPIARMFWLDDGLASNIYIDGVITVLDSEHIVTCLDDVGGHWHTSNNHLKEIQLGEGNLSAEEIEEEQKKLQEGLTTAHLQIALADTILVNKVDVLDKDPSTKAGKLAQITEKVRSINSTCPIYNTSFGDIDLDKILDLHAFEANSAKVQKSISMVSESSFHDHRIATVTLTFPFFESEEEFDQIEKFIQYVLWENVVNGKEIEVHRLKGILVRNIPGSPDVRVVQGVRETYDIISGGVLLDEITQNKLVFIGKNLDVEDLYHDLKQYISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1U3</accession>
    <name>G3B1U3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_113302</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1U3"/>
    <dbReference type="STRING" id="590646.G3B1U3"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV65012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="355" mass="38685" checksum="D79CBDA0AB1CAE98" modified="2011-11-16" version="1">MILKRFLSVKPPFVPLTTEGFTETIGNTPLIKLPKISSRINRNVYAKAEFMNPGGSIKDRAALYVIKDAESRGLIKPGGTVIEGTAGNTGIGLAHVCRSRGYKCVIYMPNTQAKSKMDTLRLLGAEVHPVPAVAFDNPENYNHQAKRHADSLENAVWTNQFDNTANRQAHIETTGPEIWAQLNGKVDGFTCSTGTGGTFAGITRYLKTISNDKTKCVLADPPGSIVHSYIQSKGKDIVRGGSSFTEGIGQGRITENLQPEIDIIDDSYKIPDEESIVMLYQLLDEEGIYVGGTSALNVVAAIRLAQELPEGSNVVTVLADSCHKYSDRIFSKSWLESKGLYDAIPESLKKYASLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1V0</accession>
    <name>G3B1V0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional methyltransferase subunit trm112</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eRF1 methyltransferase subunit trm112</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113305</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1V0"/>
    <dbReference type="STRING" id="590646.G3B1V0"/>
    <dbReference type="GeneID" id="18246891"/>
    <dbReference type="KEGG" id="cten:18246891"/>
    <dbReference type="eggNOG" id="KOG1088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086140_0_0_1"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000021">
        <property type="entry name" value="Multifunctional methyltransferase subunit trm112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="130" mass="14853" checksum="570587253CAA31D5" modified="2011-11-16" version="1">MKFITTNFVKCAVKTCSSSDKAFPLKYEECQVVLDEQQEFNPEFIVHMLDKLNWDALVKVARDLGKTDLPTQKPEGLDPIMEDDAAVLRDLHSLLIQSNIVEGKMVCENCEHIYFIKNSIPNFLLPPHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B250</accession>
    <name>G3B250_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113375</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685854.1">
        <property type="nucleotide sequence ID" value="XM_006685791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B250"/>
    <dbReference type="STRING" id="590646.G3B250"/>
    <dbReference type="GeneID" id="18246925"/>
    <dbReference type="KEGG" id="cten:18246925"/>
    <dbReference type="eggNOG" id="KOG4283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032951_2_1_1"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="448" mass="50278" checksum="34703C37682648CE" modified="2011-11-16" version="1">MQSLINDRKVGQISPGEFCRTLTESGYSALAQNCFQNVFPINCHNNAAVNSLSLETQDFQFLLSGCADSSIKLWDLHFQEQLSSQNDVDDELPDYDNPVRVFKNIATVPRKSYHDFGVSCIQWWPVDTGMFVSGSFDHTIKVWDTNELSVAYEFNLNNRVYSFDTNYENTLIATASDQPFIRLLDLRSASSAHTLTGHKEKTLCVKWHPRNPNLLASGGFDGEVKVWDIRRSTACLCRLDMLRTSSSVQAKGNLSRDSVKAHSAPVNGLVWDPLGTTLFSAGNDDRIRVWDMLSFTYPPVNKLTSFGPLMRNKYLQTIPITLNYRYESELQHLIFPSDNSDIFVFRTIDGKLVKRLNRKGSKNIGRTCSIAMGAPFSNRFYCGTIDGEILAFSPILNTVKKSDIIDQTYVLHQAQIHGASLSVGSDDELIKKARLAVKSGNSLDIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2B8</accession>
    <name>G3B2B8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113420</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685884.1">
        <property type="nucleotide sequence ID" value="XM_006685821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2B8"/>
    <dbReference type="STRING" id="590646.G3B2B8"/>
    <dbReference type="GeneID" id="18246950"/>
    <dbReference type="KEGG" id="cten:18246950"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_8_2_1"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="111"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="502" mass="54859" checksum="9357A163205FFFF3" modified="2011-11-16" version="1">MSRTSSHSRISRNSSVSDYIGTGTRNGLSSSPNSISANAHTNSLNNFLSSFKRSQSFTGQNVDVLSNSSIYEEDVLEEEGTMNETTGLIRLPANKSRRGSIISSYTIITGNSTLPQTVFNSINVLIGIALLSLPYALRLSGVVIGTMMIVGCYSVTVHTARILGEILRKKPHLVTYGDIAGYAYGPGAQLAITSFFMFDITGALISLSLLFSSSFAVLFPLSESTFKVIIYTVMFFLTFVPLNYLSMSSLAGVASVFTMVVLIFICGFTTPDSPGSLINPMPINLFPTNGSVVDVLLSIGMFMAPWGGHPVFPELYKDMKHSFKYERSCGISFTFTVIVDYAIALIGLLMFGMECQDVLIKNIMSNDNYPEFVKPCFLIIMGILPMSKMPLLAKPIITTYENYFELNKEKMTIVDIVKKLSARVLYVVLSLGVSLMVKSFGKVVAFFGSSVCFALCMVFPYLFKLKILKDEISKTETIWLWSGVIFGTVIGALGTLGVVIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2G0</accession>
    <name>G3B2G0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_104045</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685470.1">
        <property type="nucleotide sequence ID" value="XM_006685407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2G0"/>
    <dbReference type="GeneID" id="18245676"/>
    <dbReference type="KEGG" id="cten:18245676"/>
    <dbReference type="eggNOG" id="ENOG502QREF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008074_2_0_1"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="479"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="781" mass="92110" checksum="13BF6380989F6251" modified="2011-11-16" version="1">MIYYRAIKILFVMVLATNIVYFTRTYHLRETELKQAELNHISTISYDTDDQVQFSPNKPYAELDQLEKVAYLLKSVDSDKERFWLAQTEITEPNLQINPQDFLPGANDESPNWSNKPTLFYDPRFTLSVYINEIKHQLLTKNPHNEKAKDNMITVPFAWSDWVDLTMLNEELAKPVDERADCGWLQEKVNKPTKYPDFCVNLRDLPDEELAEIGLPSKEYLPGFVVKGSPMNKAPHKQVMMQGKAHLLTHQENPLSIIFLTKDGTYEAQVAYKQRIVHSSMFSEFLSRKNIDVTGDSMVDEVILNPITEFRDLNREVKSRPLNWDDDIYKMNSITRQKSANASRELYLDPKAFDYKVEQVEEQIIEYETRLDHLKDALTNELHYDLAYIQKIKLDRHEMNHYKSLKHAYSVPLKDETTYYKLATLLKVDGNKDAGWHYEWRFFNGGLRYLKDGWTQTQLEIREQIILDRLLRNWFRFAEEKGIISWIAHGPLLSWYWDGLMFPYDIDIDIQMPSAELNRLSKHYNMTLVIEDVNDGFGKYLIDCATFLQHRDMAPKDNHIDARFIDVDTGTYIDITGLGKNEESPPQEFNSYIRNKNAKGDSVNLYSDRRKHWLTFESISPLRYSMIGGVPVYVPNDIMSMLNHEYPKGTTSYQFEDYFYVPILRLWLKRDRLQVLLDDKGLKDINLDQMTEFLKGLTVDDKVKLLETHDSVLIEYYLTHKHTQLHEIEKKFMLDPTLQYSILDLKDNYDYHQLTSNFKMGSPLRKSLYDYEYIERLKHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2G2</accession>
    <name>G3B2G2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_120491</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2G2"/>
    <dbReference type="STRING" id="590646.G3B2G2"/>
    <dbReference type="GeneID" id="18248782"/>
    <dbReference type="KEGG" id="cten:18248782"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="15">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="477" mass="52013" checksum="8D4D8B827AB93A23" modified="2011-11-16" version="1">MSGFRVLDLVSPFTPFVPEVIAPERKVAFQQRVMWTGVTLLIFLVMSEVPLYGIVSSDSSDPLLWLRMMLASNRGTLMELGISPIVSAGMVFQLLQGTKLITVDMGNKSDREQFQTAQKLFAILLAIGQATVYVLTGMYGPTSSLGLAVCLLLILQLVFASIVVILLDELLQKGYGLGSGISLFTATNVCEQVFWKTFAPTTTNVGKGVQFDGAIVALFHLLGSRQDKKRALLEAFYRTTGPNMLQVVATVVVFFAVVYLQGFRIELPVKSTRQRGPYGVYPIRLFYTSNIPIMLQSALTSNIFLISQFLFVKWPENLFVKLLGTWDARYGTNRAVSGLAYYVQPPTAFSEALLDPFKTVIYVVFVLGSCALFSTTWIEISGTSPRDIAKQFKEQGLVIAGHRDTSAYRELKKIIPTAAAFGGACIGALSVVCDLMGTLGSGTSILLAVTTIYGYYELAVKEGGLKSSLVSGFSDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2G5</accession>
    <name>G3B2G5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113459</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2G5"/>
    <dbReference type="STRING" id="590646.G3B2G5"/>
    <dbReference type="GeneID" id="18246967"/>
    <dbReference type="KEGG" id="cten:18246967"/>
    <dbReference type="eggNOG" id="KOG1523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034396_1_0_1"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="9">
        <location>
            <begin position="107"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="372" mass="41195" checksum="3C16329F9B88499E" modified="2011-11-16" version="1">MSTPIVYQLGHKPIKDHVFSSDRSLLAITKDNTVEIYRIGTAKPQLVTTLKGHDKTVTSVDISPDNSKILTCSQDRNALVWEYSQAEGEYKPTLVLLRINKAATCCRWSPNGDKFAVGSNDRIVAICYYEEENDWWVSKHLRLRSTVTSLDWHPNNVLLAVGSTDGHARVFSTFIKGLDAKPAPSVWGSRLPFQTLCGDFTNETGAWVHAVSFNPNGDSLAYVSHDSSLVLVYPEGEGLPPKNIVSLKTNYLPFKSVLFLGENSLVASGHNCNLIVFQGDESGWKQTKELEQQKDLIHDLPPKTDEDEEISSHDALNMFRQLDLKGKVNKASDKSGKALSTIHQNTVTAIKYFTKGKVSTSGIDGKVVIFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2H3</accession>
    <name>G3B2H3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113465</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685481.1">
        <property type="nucleotide sequence ID" value="XM_006685418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2H3"/>
    <dbReference type="GeneID" id="18246971"/>
    <dbReference type="KEGG" id="cten:18246971"/>
    <dbReference type="eggNOG" id="ENOG502QTAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044733_0_0_1"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51935" checksum="B661AD78F68062C7" modified="2011-11-16" version="1">MYRAPDFFERYNVCRISVNHYSNYHVTAQYNQTISRSLLSNALKQLILHHPALYYGVKLNPKLIDYKTYQNHQVGPVKSISFEDVVTISDKPFSEERLVEINHLCIPVDDENSVTWRIIVFSNNYICLYSNHIIIDGGAAAFFHHDLCAILAELSSQHLEFVPELYNQQVDGVKQHLGTDHVVDLYRCTSKLQAMSMVVASFIPKSVTQLWNSYTNKHYPDLQKFPLFECEQRKVIDDEFRLFQIPDETMTRLLAKCRQEGVTFTAFLDVLINHCFQKCVFPLISSQKLSTKSSIVTSGRRYYPEKAAELRYAQVVTGTEIYLPPIESVSVEAMKVVKQIIDTDLETRNRFKYVGLLSMINPYDILAPEKTEFHQDVLFEISNLGLQNIKNGDWAVSDIVFCQCTGPSTTFGFNVATTPGGTKITMGIKSQYAQSGMDEFEKAFYAGIEQFCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2L7</accession>
    <name>G3B2L7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_104041</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2L7"/>
    <dbReference type="STRING" id="590646.G3B2L7"/>
    <dbReference type="GeneID" id="18245675"/>
    <dbReference type="KEGG" id="cten:18245675"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_5_0_1"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="17">
        <location>
            <begin position="893"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV64709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="988" mass="112183" checksum="5DFF35DF174E8DEC" modified="2011-11-16" version="1">MPSDKKRLSSGLTVTSKVFVMSRNGSATKVVREHYLRDDIVCYSTACNKCAELIKENPDGQIPNIQLSDVPAKLQNERHYIVVDTNIVLSAIDLLENTECFYDVIIPQTVLDEVKNKSFPIYQRLRSLVKAEEKRFVVFHNEFHEGTYVTRKHGESMNDRNDRAIRKVVSWYDNHINHDNSIEKINLVFVCNDKDCRKKAEAEGIYTKSLVDYVEMLPKADYLRELVSNDNQTFTEFQNEAKYQEYYSEARIMAGVKNKSLFKGILNISRYNFLQGTVQVPDFKKPLLVVGTKNLNRAFNSDLVVVELLPQDKWRSPSSTIVEEGSIDDYDNPDDDDDGATASNGIIPDKERILLAQEATKAITLASSGNTDVEHKLQPTAKVVGVIRRSWRYYVGQIAPTSVSADDNGNASRACFVVLMDTVLPKIRIRTRRAKELLGKRIVISVDSWEATSKYPSGHFVRSLGDIESTEAETEALLLEHDVEYRPFATNVLNCLPKEGDKWKVPENLDNGDEQLKKRKDLRGELVCSIDPPNCVDIDDALHAKPLPNGNFQVGVHIADVTHFVKANTALDDEGASRGTSVYLVDRRIDMLPLLLGTNLCSLNPYIDRYAFSVIWEVDKDANIVSVEFTKSIIRSREAFSYEAAQKRIDDKSQNDELTKSMRILLNLSKKLKQKRLNNGALNLASPEVKVHMDSETSDPGEVEIKQLLETNSLVEEFMLFANISVARKIYDSYPQTAMLRRHAPPPASNFEQLNDMLSVRKNGMHISLENSKALADSLDNCIDPKDEYFNTLVRIMSTRCMMAAEYFPSGFFGYSDFKHYGLAVDIYTHFTSPIRRYCDIVVHRQLAGAIGYEDLAQSHRDKNKMEFIVKNINKRHRNAQFAGRASIEYYVGQVMKSNESIQEGYVIKCFNNGIVVLVPKFGIEGLIRLEDLGDTDSAIYDEDKFELHFNDLHKNKRTIGVFDKVKVEIKSIKDEISGKRKAQLILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2L8</accession>
    <name>G3B2L8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_104447</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2L8"/>
    <dbReference type="STRING" id="590646.G3B2L8"/>
    <dbReference type="GeneID" id="18245717"/>
    <dbReference type="KEGG" id="cten:18245717"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_0_1"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="203" mass="22307" checksum="EF771FD97E0C12FA" modified="2011-11-16" version="1">MSTVFTPIPEALEAFKNGEFLIVMDDEDRENEGDLIMAAELITQEKMAFLVRHSSGYVCVPLSKERADTLELAPMLANKTDKHGTNYTITCDYAVGTTTGISAHDRALTANKLADGTSKASEFIKPGHILPLRAAAGLLKERRGHTEAAVQLCELTQLEPAGVICELVREEDGLMSRLDDCVEFSKAHNIKLINIKQLVEYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2N4</accession>
    <name>G3B2N4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBS-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_104365</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2N4"/>
    <dbReference type="STRING" id="590646.G3B2N4"/>
    <dbReference type="GeneID" id="18245713"/>
    <dbReference type="KEGG" id="cten:18245713"/>
    <dbReference type="eggNOG" id="ENOG502QVK2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009026_1_0_1"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="142"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="247"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="469"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="68576" checksum="354500E25ED293E4" modified="2011-11-16" version="1">MSSINRSKSSYGTSSVSDSSSIGVQHEGVSDSRRRQSKRDDAIRRKIESDLSKKRRGAAKVSRQRKATPGTVLALKPSEAVTCKPSTTVFEASQLMTAKRENCILVVGEDGELLGIFTAKDLAFRVVGSNLNANVITIDQIMTPNPLCTNANDPASDALTVMIQKRFRHLPVLDNRDRIVGVLDITKCYSQQMEKLERMHESSKRLYEAFDTVHSEMAVVQQPLQVFQYFEELKSKMNGPTLDTVLDSRTVPIYCSIKTTVYEATVLMKENNTTAVLVKDNEDKVNGIFTSKDVVLRVIAAGLTPKNCSIVRVMTPQPDVARHDLSIQESLRKMFDGHYLNLPVVGDSGDIIGIVEVLKLTYATLNQIKQVKDQESPEIVSEAKSGGAEGPAWNKFWTSLDNDADSVNSDSLVVDSSGRPQTPTNLTSQAGLTSSDLNLDIKPSDSISHIETPQKSRTSLLDSLDESFVLKFKSPANENRVHRISIKPTDGLTKLRELIDEKLHPKDFQYLRVTKVNDDGKTYAISYVDDEGDIVSITSDNDLLDCVKINLRLASHKANLYLHNPHEPAPIENIKIRKPKRPRRVSENGFFGVPNEVLIPGVLLVLATATLIGYSVNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2Q6</accession>
    <name>G3B2Q6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="19">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTEDRAFT_113516</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="19"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2Q6"/>
    <dbReference type="STRING" id="590646.G3B2Q6"/>
    <dbReference type="GeneID" id="18247000"/>
    <dbReference type="KEGG" id="cten:18247000"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="5 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="42"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV64734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="285" mass="31771" checksum="B55FB33BE1FAA799" modified="2011-11-16" version="1">MSADSEPNPLVVFATIAAIISSFIALYFIKQRNKNQPVLDKTQFKKFPLIEKTRISHNTCVYRFGLPKSTDRLGLPIGQHISIGTTINGKEVVRSYTPISTDDQTGYFDLLIKVYEQGNITKHIDSKKIGETIDVRGPKGFFTYTPNMVKSFGMIAGGTGITPMYQIMSAILKNPQDTTKIHLVYANVTENDILMKAELEQMKAQHPDQLFIHYVLNTAPENWEGSVGFVTPEIMEQYLPKSTDDTNLLLCGPPPMLSAMKKAAMTLGYPKAKPVSKLGDQVFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2U3</accession>
    <name>G3B2U3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_134074</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685569.1">
        <property type="nucleotide sequence ID" value="XM_006685506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2U3"/>
    <dbReference type="GeneID" id="18249763"/>
    <dbReference type="KEGG" id="cten:18249763"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="58"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="558" mass="60673" checksum="408B9A01FE6040D3" modified="2011-11-16" version="1">MKKTSFESLDFDASNTIINTLTSTDPTPVSTWHNLKNSFKRQPGNPELNQTLKKRQLRMISLASCIGSGLFIGGGSALKVGGAGGVLIGWAIVSVYLYCVMQSLAEMVAVLPISGSFAAYSSRFVDPSWGFAVGWNYALFWVVVLPLELVASAMTIKFWPSAINPVVWVAVFYVLIILLNLCGNKGFGEAEFVSAVIKLLAIVGFNILAIVIICGGTDAGFIGARYWHHPGPFANGAKGTISVLITAVYSLAGTELIGLTASESKGNPRTELPHAIKLVFYRIVVFYMVTLTLVGFLVPWNSDQLVGSSSSDASASPFVIAINSAGIKVLPSIFNVVVLIALLAIGNSAVYGFSRTILSLAQQGLAPRIFMYVDRAGRPLMGILVAAVVGLLAFVSATPDQEVVFAWLMALSGLSTLFTWASVSLVHLRFRMGMKAQGRGLDELPYLANTGVGGAIVGLVTSVVILVLQFWISLYPVGRAPNAKVFFQNYLGAVVVLVFFVGHKLYSRKLNAVVRLHEMDLDSGRRELDFELMRQVIETEKEELRMSSWYRRMWRVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B370</accession>
    <name>G3B370_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114134</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B370"/>
    <dbReference type="STRING" id="590646.G3B370"/>
    <dbReference type="GeneID" id="18247277"/>
    <dbReference type="KEGG" id="cten:18247277"/>
    <dbReference type="eggNOG" id="ENOG502QT50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079101_3_0_1"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="218" mass="24947" checksum="0CB1711CB7903C4C" modified="2011-11-16" version="1">MKILGTDEREAHIAHITAEGTKGLFYGSLLSAGLFAYLRTRHPVRFSQFNTSIKTCIFAMPTIATAAFWADQGSVEFDRQMHSSDYQQEQLLEQYKEWQSMSKYDKSIHFLNDNKYKIVLSAWAASLYGSWVLVNRDKIMTTAQKAVQARMYAQGVTVLLLIGTVLLAVKEEEINKKKPAPIPEWQKVLNDRAEEEKEKKRIVAQIKKAKAEKEELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B453</accession>
    <name>G3B453_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein FYV4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113821</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B453"/>
    <dbReference type="STRING" id="590646.G3B453"/>
    <dbReference type="GeneID" id="18247131"/>
    <dbReference type="KEGG" id="cten:18247131"/>
    <dbReference type="eggNOG" id="ENOG502SCMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126121_0_0_1"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="7">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="156" mass="18503" checksum="A55B40FE96C8FFA6" modified="2011-11-16" version="1">MFKRLTSIIPRSVVPVPTQATRAFSYTPIFHKTNTSTRTRENVHDLETFFTLIGRNSVEHLELFEGDLNKFLETDSKTMKNLGIDTRSRRYLLRWRHKFVNDLEPLREHTRGKKKNGGERKAKLVKAKRTALQRLEERENFQKQELEAEEKGERDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B456</accession>
    <name>G3B456_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113823</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B456"/>
    <dbReference type="GeneID" id="18247133"/>
    <dbReference type="KEGG" id="cten:18247133"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="154"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="611" mass="68552" checksum="ECFEABEB9405E981" modified="2011-11-16" version="1">MKSELYQQYSQENTSSSSSHNTPLPIAFHGKDQDNHSRRGSRNSLGKSLETIRRSLTGQSVFSNVSQFSVKEIYGDLNSTEIERERARTKKDVLSEIQQNLDNDVEPFVLPESGLPIEKDGEEYGLIDPELITWEGYGDPDDPRNWSVTKKVYLLGFVSVYALVSPMSSSILTPAMSDISKEFHITDPVITSMVASIQILAWAVGPILIAPLSEFDYIGRKPVLDMSILMSFFFNLGCSFSKNTAQMMVFRFVGGLFGSSPLNVGAGVISDMFDAKSRNVALAGFTLAPLLGPVIAPMIAGFIVDNLQWRWVFYVLTIFNGVVAVLGMIFFKETYSPKLLKDKAKALRKSTGNTNLHTIYEITNQKFSTRMISTMTRPIKLLFMHPMVIGLGSFLAFVYGFMYLLIITFPTMFAENYGFSKSVIGLMYIPMGVGFTVGIAFWTVVIGKTYERLEERNNGVAKPEFRLPCLFIVGIIIPIGLVWYGWSAEKKLHWIMPGIGSGIFAFGFICAFQCCQNYLIDMNPRFAASSVAAAALFRSLFGFTFPLFANKMYRAMNYGWGNTMCAFIAFLLGVPFPIYCYFHGEEMRCRFNEKFDNEQKEQDKHALKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B466</accession>
    <name>G3B466_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_104863</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B466"/>
    <dbReference type="STRING" id="590646.G3B466"/>
    <dbReference type="GeneID" id="18245759"/>
    <dbReference type="KEGG" id="cten:18245759"/>
    <dbReference type="eggNOG" id="ENOG502QSVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010226_0_1_1"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442514" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="720"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="786" mass="88004" checksum="43F8A1D3FC82C820" modified="2011-11-16" version="1">MVTLISFLWFFTTISAQRFVKTSSLLTCMDNSQFTATHFDVKFFPDNNTAVVDVTALSNIDANVTANVEFIAYGLTAFTSNISFCSLNYETICPFTTGHLEVNTDFKVPKADTSQIPGIAYTIPDLDARVRVVLLDSDTDETLACVEAILTNGKTVQTKYASWPIAAISGLGVITAGVISVIGHSNTAAHIASNSMSLFIYFQSLAITSMMAVAKVPPIAAAWAQNFQWSVGIIKLGFIQDISNWYIQSTGGTPTDILDSSYLSISVQKAKRSAVEFINDLYQKAQYSQHVTLFKRLTLSIATDDFGQSDTLDPDLYSVNEKDNDLSSKILVLRGIQRVAYLAGIEITNVFMTSIIFLLFFAFVMIVCLMLFKAVIEILIRSKIMNEGKFNEYRQQWSSIIKGALYRLMVISFPHVCVMCLWELTTRDSTGTVVVAVFLFVICFALLYQAAVRVILRGRRSVQQFKNPAYLLYGDGPFLNKFGFVYVQYKADSYYYVLASLSYVFLKCLFVAVLQTRGEVQSVIIFAIELIYFVGLCYFRPFMDKRTNAFNIVIAVINTINALFFMFFSYIFGQPQIVASVMGIVYFILNAVFALFLLIFTIVTCVLALVYQNPDTRYQPMKDDRVSFIPRFDNKSAKPGQPINQDDEDYELMALGASAMKGHENKVSHFEDDDSVYDEETSSGFANQSRNHQNAYQSNSTTSFKADDPKRNSYYMENMEPTQPTSTIVGNPGTAFNNYQRTGQGNSNIAYQNNNNSSSSVSFKNPYQQKSTAYGGSSSNQRVNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4F1</accession>
    <name>G3B4F1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_113850</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4F1"/>
    <dbReference type="STRING" id="590646.G3B4F1"/>
    <dbReference type="GeneID" id="18247145"/>
    <dbReference type="KEGG" id="cten:18247145"/>
    <dbReference type="eggNOG" id="ENOG502S890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177920_1_1_1"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV63809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="72" mass="8126" checksum="4329FCACA710AD18" modified="2011-11-16" version="1">MQNPHEQAQSALLSRIINNVENLNESVVAMNKSLQEINRRNLDIEIASQLWEGYASNAAFDLERTGDKTDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4K0</accession>
    <name>G3B4K0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114001</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686278.1">
        <property type="nucleotide sequence ID" value="XM_006686215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4K0"/>
    <dbReference type="STRING" id="590646.G3B4K0"/>
    <dbReference type="GeneID" id="18247209"/>
    <dbReference type="KEGG" id="cten:18247209"/>
    <dbReference type="eggNOG" id="KOG3037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041798_0_0_1"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="277" mass="31192" checksum="63E5EEA31B1A3FBA" modified="2011-11-16" version="1">MSTIKFNAGKVEYDEDTHECVPFPQKGVVTITPRSEEGSFYNFNWTQKSSEDGYFEIQEYLIIPGDVSFKQVSSCKTGRVLALTFLSSGAKHLFWLQDVGDDEELDKLTDKDVDLVKRINELFTPMDDEDEDEDEKPQKEEPPQPATTTNEPSTSTSAINLPILDLEDAFPFEVLETHLNRLSDKQLLELVKDDLPPTIGQNPTRANIYDLIRSGFFQQSKANLTQHLRNANGAGYLLAQSFGLEYQGEGISNFLEGIRKSSKKPHEESPSDDTTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4S1</accession>
    <name>G3B4S1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATPase expression protein 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113883</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to the 5'UTR of the OLI1 mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AEP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4S1"/>
    <dbReference type="GeneID" id="18247162"/>
    <dbReference type="KEGG" id="cten:18247162"/>
    <dbReference type="eggNOG" id="ENOG502SDKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_493556_0_0_1"/>
    <dbReference type="OrthoDB" id="4077974at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024319">
        <property type="entry name" value="ATPase_expression_mit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12921">
        <property type="entry name" value="ATP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="470" mass="55968" checksum="60920A5D42B19A25" modified="2011-11-16" version="1">MDHQIDTLLELTRARQGKMAPARVSELQTKADTWRARIRDLYSNLLFEDHVSIYSESLRVEFYKPSISTGIRLSVGDFENLIVFEFSNNKFDLANKWFDRFDQEFNMDQYTPKMWDIRFKINGGDPRLWKVYENDVFIVNTNVAHSYYKRMPLSQLLNSFLKHNKLESQIENIILCLGYYRKVDSIYQLIHEIYGVDVSGEKVPNKIISDTNISIGVLNSIVIALSYNHRYFESMKFINAFQSHASVYLESQEAGFFWGNLLKWTDLTTKFNKKMVLDYYIKNINPQAKHSTLPDLMNDVNFDYERYLQFTEDLIQKRVNIMRQIWSLFQSSNGRFSVVAYKTYWNFLKRSGTEQEVFEFLELLNSHNYQFSVTRGSFNFKYLGLNNTLWSIQSLYYQAIKWMIEAKLNNQLVGQVQPLINEWCLDYQMRAEATQFFKTRLPKLAKKIEEKREQEMIKQRQDDEPFLELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Z6</accession>
    <name>G3B4Z6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_93530</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Z6"/>
    <dbReference type="STRING" id="590646.G3B4Z6"/>
    <dbReference type="GeneID" id="18250298"/>
    <dbReference type="KEGG" id="cten:18250298"/>
    <dbReference type="eggNOG" id="KOG0136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014629_3_1_1"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000018">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF352">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="18">
        <location>
            <begin position="35"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="156"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="19">
        <location>
            <begin position="295"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="16">
        <location>
            <begin position="508"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV64025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="703" mass="78914" checksum="104E6E75FB35F46B" modified="2011-11-16" version="1">MSLSVKNTVDSSRGPDPKTSITTERANNQKWDPVLMNHFLEGSKEASELNRTMYQQMERDPILRANPHYYDLGKEEERELTALRIDRISQYLESDTPAEYNRRASLISVFDPQLNTRIGVNLGLFLGCIRGNGTPEQLKFWSASKETKILKHIYGCFAMTELAHGSNVAGLETTATFDKENDQFIINTPHIGATKWWIGGAAHSATHTACYARLLVDGKDYGVKTFIVPLRDSNHKLMPGITVGDIGAKMGRDGIDNGWIQFSNVKVPRFFMLQKFCKVSREGDVVLPPLEQLSYSALLGGRVTMVLDSYRVGARFSTIALRYAIGRRQFKSGKNELETQLLDYPLHQRRLLPFLALTYLVSCGAMKLEKTYDSVLDGLDEAVEKNDMKVISKSIKEMKSLFIDSASLKSTCTWLAADLIDQSRQACGGHGYSGYNGFGKAYNDWVVQCTWEGDNNVLAMSVGKPLIRSIDEILNKDKKASGSISFLNNAKQYLNEDNVLKSFEDVNDLKKVLLSIEILIIRLCKDSLDTIKQNGGQYEIVSGSMVTISKLKAHHYLLNEFLIRTEAADASLKPFLTLIARLYSASIVLDKFSGDFLTYSVVSPKFMGKINQEYIPKLCLEVRPLVINYTDSFQQPDMALNAPIGNFNGDIYENYFGVVKQENNPFNYKAPYSAALESMLNRPSLSDRQRGERSDSVKDILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B545</accession>
    <name>G3B545_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114455</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B545"/>
    <dbReference type="GeneID" id="18247429"/>
    <dbReference type="KEGG" id="cten:18247429"/>
    <dbReference type="eggNOG" id="ENOG502RQ25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062048_0_0_1"/>
    <dbReference type="OrthoDB" id="4097133at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="262" mass="29319" checksum="1367EC0F045EF93F" modified="2011-11-16" version="1">MSDKEEEPVIELEEGELSKEERLEAARKRYEELKKKKKGKKKGKKEKKDKSEDSPVPEDNDEPETEAVDTEAVATEAAATETVDTEASIETETPVDPEAVDTESVETKKPVESESANTPEIAPTTSDVTNPPVPSADASSPSEIASLKDTIFKHEKTIKKLRDENTDLKLEKMDMKDKISELQATIETLKTGNGASQHQPPVRKLEPAKPIITTNKYASASKQDLNDFSNLSDFRERLMVWKHWQVDMTSWNSVYATEKVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5A1</accession>
    <name>G3B5A1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_106103</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686961.1">
        <property type="nucleotide sequence ID" value="XM_006686898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5A1"/>
    <dbReference type="STRING" id="590646.G3B5A1"/>
    <dbReference type="GeneID" id="18245863"/>
    <dbReference type="KEGG" id="cten:18245863"/>
    <dbReference type="eggNOG" id="KOG3007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_0_1_1"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38287" checksum="2CF98FA1FB8E3165" modified="2011-11-16" version="1">MKILSDKDVSKVLEDVTRDTLLKVYQPHLLESLRKLSQTPESLPGRIVQASTTRSSDSTHLFMPSVAPSEVGLKVITGGPTNSKKGLGFVGCVLVLDEHDGSLLGVLNGKTLTAFRTALASSIPMVRVLDPFECEILPQVSVFGSGLQAYWHAKLTVILYGDKIQTINLINKSLHNAEVLQQTLAKEFPNKSFTVLSYADESQAEDVHRAVYHSSIILGCLPSTEAVIKKSFLNPDKNVPKYINLIGSYKPHMLELDSEVIHSEFNDGTRIIVDSKEHCLHESGELVQSKRTAENLIDIAELCSQGSGGSVRVTSRSNITISKLVGLATMDVSIGKLLLRRSHGGVEIGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5E1</accession>
    <name>G3B5E1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114511</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5E1"/>
    <dbReference type="GeneID" id="18247458"/>
    <dbReference type="KEGG" id="cten:18247458"/>
    <dbReference type="HOGENOM" id="CLU_2596471_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="80" mass="8843" checksum="09A0D4ADAE8E2A48" modified="2011-11-16" version="1" fragment="single">MPTKRSTRSNISSPTASPQSRRRTAARKADLSGLDLDPEPADDDEYSEPGQDEDPDDSILNDEEDVKPAKRKRDISSVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5U9</accession>
    <name>G3B5U9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114605</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5U9"/>
    <dbReference type="eggNOG" id="ENOG502S36W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1343113_0_0_1"/>
    <dbReference type="OrthoDB" id="4067208at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="205" mass="22590" checksum="5BE8CC8E2AD3AB2A" modified="2011-11-16" version="1">MSLEIESDQKQFISSYLQLIALSDEKPLSAFNSIADYSSLTSLGPSLPIFEIPFPSTDSSISTVDLSFKSIKPPFKFQTELKAIPESQSIFNVKSLLIDSLALNENNVKPADIKLLIKGKVIQDSTLLSSLDSYAFMCMVSVPVSSTTNIPSVPIPSESADPDVDISEVWSVSKTAWKRIYEVLKTDLQSEEKATEVLNKFKSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5V2</accession>
    <name>G3B5V2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114606</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5V2"/>
    <dbReference type="STRING" id="590646.G3B5V2"/>
    <dbReference type="GeneID" id="18247500"/>
    <dbReference type="KEGG" id="cten:18247500"/>
    <dbReference type="HOGENOM" id="CLU_639339_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="429" mass="49668" checksum="5078C0817016B7A1" modified="2011-11-16" version="1">MIVPVLIRHAQALGLHRVHRNSSPLSQEQYDLHIRLWWYCEYIDISVCYKTGNSCLVSSNDVTTFRQLDAEFDSLSGPLTVKEHIINSHTIEHVRDKQFYQFYSSYFLISLNRIKRRSYESIFSAKAQMENQSEEHFHRVIDNVCKELDELCRLADPGLRPKLPYQDFKDDHRLNPALQNGSKTNNLDFTMMLFRIDYLAHYLIIHRASMASKEKDVKRYNLHLSRSVDCARAIVHIINGLNTADKRSVPKGTVIYFALVGFMTLLANTVLHPNEANAMDDFKILQECTTGFFCSDGVFKNVNSHFNVYRFEQKACFCDLIVRIMMKLLLRVMSSQSKRDLGTELSLSKYVGILEEYYPQLFASEDDKQNPNSRTDNKRLEPTLANLINSEDEGRPGKSFFLEALLDPRKPEEFFTSSVSGLPNFFHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5V9</accession>
    <name>G3B5V9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_114611</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5V9"/>
    <dbReference type="STRING" id="590646.G3B5V9"/>
    <dbReference type="GeneID" id="18247504"/>
    <dbReference type="KEGG" id="cten:18247504"/>
    <dbReference type="eggNOG" id="KOG3110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_3_2_1"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="12">
        <location>
            <begin position="12"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="177" mass="20038" checksum="B53A843965B34E8E" modified="2011-11-16" version="1">MRDPIKTKISEPYPIIEESEIINGFGRGSSELGIPTANIPISSNLNKLDPGIYFGFSKLIPVSKDLETKKRSDGHLVEFNHGANLSGEETCVFPMVMSIGYNPFYNNTEKTAEVHIIHKFQDNFYGAKIKHAVLGYIRPELNYTTKEALIEDINLDIEMALRALESSEYNQYKHKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B677</accession>
    <name>G3B677_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_107062</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B677"/>
    <dbReference type="STRING" id="590646.G3B677"/>
    <dbReference type="GeneID" id="18245932"/>
    <dbReference type="KEGG" id="cten:18245932"/>
    <dbReference type="eggNOG" id="KOG1009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010127_0_0_1"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="3"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="461" mass="50711" checksum="AECCA7079E9D4554" modified="2011-11-16" version="1">MNSSTITVHWHDANQPVYSVSFQPEVGQTSPSPRLATGGGDNNVRIWRLSPQNDKSPVQYLSSLNKHTQAVNCVRFSPDGTQLATAGDDGTVLIWTLSPTLVREFGEEDDGAVESWTCRTAMRASTSEIYDVCWSPCGRYVAAGSMDHAVRFYDVKSGLMVHQAVVHNHYIQGLAWDPLGKYVASQAADCGMCLYELGEDHDENSLFVTETYKSYKADVPGKRLSEDPTATTKHAGLYHSETLQSFFRRPAFSPDGNLLATAAGVYRPEADDETNTVYISVRTAFHRPVVHLPGLKRPAVAVQFSPLVYERSTPTAVFDLAYKMVFAVVTQDSVVVYDTERLEPLGVVSNVHYSTITDLAWDRDGQRIMVSSADGFCSVVRFDEGIFGKVVDLVHPSPPAEVRIAVETKVVDTPEPASPEKSSETPDKSPGPSIINLLQTKKKEKKRVAPTPVETVDLETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6D0</accession>
    <name>G3B6D0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114742</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687470.1">
        <property type="nucleotide sequence ID" value="XM_006687407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6D0"/>
    <dbReference type="STRING" id="590646.G3B6D0"/>
    <dbReference type="GeneID" id="18247561"/>
    <dbReference type="KEGG" id="cten:18247561"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="238" mass="26234" checksum="B0B9C1CC73C7906B" modified="2011-11-16" version="1">MATLGSCCTEKILHEGTPAGSYSTVHGLDTYVTGDVTNKKILVIITDIFGYKLNNVLLLADQLAKLGGYKVLIPDIFDGDIFVAGNDVQAWFPKHSESIVAPIINDFLKKLKEDEKPTFLGGIGYCFGGKYVMQHLSKDGYFDAGATPHPSLVVTADVEAIERPLLISTPYADQMFGNDLRRETEDILSKKEGLKWEITLFSGVTHGYSVRGDISQPQIKYAKEKTVMDQLAFFANCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6K9</accession>
    <name>G3B6K9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_135298</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6K9"/>
    <dbReference type="STRING" id="590646.G3B6K9"/>
    <dbReference type="GeneID" id="18249865"/>
    <dbReference type="KEGG" id="cten:18249865"/>
    <dbReference type="eggNOG" id="ENOG502QQXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006632_1_1_1"/>
    <dbReference type="OrthoDB" id="4093587at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="717" mass="83079" checksum="0A937A6AAB881180" modified="2011-11-16" version="1">MPMFWLQKVSVRSPENPEQKLIITLLSHQLLLRPPPAGYFYRDKLKPHNQYTSIPMSEVQLERPTRPCDRCRKRKTKCVFESGQEKCYLCKMSHQICEFNLPPLKKKRKAKSPSATDISANGMSIKKDSPGSPIPDDPKHVELPKYFFRLEGNNEFDQYIFGSLLDSNSIELYPVESIKRTILTSNGTIFLQAEGNMEDVEERKVEIEKINQIIGNVGPKLVALYFRIVHTSFPILSKNKFLEEYTEDQGHISPCLLSCLYLFALNWWSFDSDLSIETKPSQKEIEVLAEANFYREIKKPMISTVQAGLLLIQHQSFRDRYDNPCDCWPHQSAVYACAQSLGLNKDCSSWNIPVWEKSLRRRLSWGLYVQEKWLSFTSDKRSHIDSKDWTVGDLDPIKDFEDFKETEMESENIIDGKIDLEIGKTLFLQKVELTKIVNEILLRLHSEEAKSVLNCLPVQDPLLSLKKTLEYIKPLQIRLTAWESRLPTNLVIETNVSRGFISGAPNIYISNFSAQVSVLRPVLRILSSIRESKLLVDKEFIGIRDIVYNKCMTILEKFIKFLSELRAEHLQTFWYTSARNGLSNIVVFEFLLALVSKNKAELDNCLDKIEESVWKLKLNNKNAEFFSHAISWWNILKKHLTFKLENFVFYNEGNIGENRIENGKIKDELIYEDPNIGNSLTNPMDRAQTIGNESYLSPEYFNIDSMDNFIFTYQNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B717</accession>
    <name>G3B717_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_122822</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573</strain>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B717"/>
    <dbReference type="STRING" id="590646.G3B717"/>
    <dbReference type="GeneID" id="18248933"/>
    <dbReference type="KEGG" id="cten:18248933"/>
    <dbReference type="eggNOG" id="KOG2833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="194"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV63074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="381" mass="41898" checksum="5157FC4B9CB15382" modified="2011-11-16" version="1">MTVYQASATAPVNIATLKYWGKRDKTLNLPTNSSISVTLSQDDLRTLTTASCSADFEQDQLWLNGALESLSSERTQACLKDLRTLRKGVEHKDASLPKLSEYKLHIVSENNFPTAAGLASSAAGFAALVFSIAKLYQLPQDLSEISKIARKGSGSACRSLFGGYVAWEMGESPDGEDSKAVEVAPLEHWPNMKALILVVSDDKKDVPSTSGMQSTVATSDLFNHRINELVPQRFEEMKSAILKKDFPTFAELTMKDSNSFHAVCLDSFPPIFYLNDTSKKIIKLIHKINEIEGKTIVAYTYDAGPNAVLYYEAENEDKILSGLKPYFENIQGFKQPQTVTSFDFKSFIPEITGVSKIIATKIGEGPKETSISLINESGLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B787</accession>
    <name>G3B787_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_98789</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B787"/>
    <dbReference type="STRING" id="590646.G3B787"/>
    <dbReference type="GeneID" id="18250802"/>
    <dbReference type="KEGG" id="cten:18250802"/>
    <dbReference type="eggNOG" id="KOG1149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_1"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="47"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="504" mass="57368" checksum="377413989216FC55" modified="2011-11-16" version="1">MKIGYHWLSGTRGSPETVSSLMEPKVPLLGMYVNNGIKSVHPHIPAVTRFAPSPTGYLHLGSLRTALYNYLLARNTNGKFILRLEDTDQTRLVAGAEKNIYDTLKWCGIQPDEGPVQGGIHAPYRQSERKHIYKEYADQLVAQGKAYHCYCSKERLGDLRESAMKLKPPTTVTYDRKCFHSHSQTSDEQPVIRFKSPEKYDKINDVVHGILDLQPQYNSEDRRYDDFVILKSDGLPTYHFANIVDDHLMGITHVIRGEEWLTSTPKHQALYQAFGWTPPEFVHIPLLTSLKDKKLSKRDGIMGVLSMSDKVLPEALINFVALFGWSPPRPSPGESVSEVMSMDELVEKFSLDGLTRGNAKVSNAKLYYFNKEHLHRLAKVDEKVVELAETYDLTDDTEYMARVLKKLLPSMSSLDEINNYKYLFTIPDYNTSNAPPNCKAVLMRYAELEYNVEELIKEFKKKEVFQSIRFALSNGAPGLAIPEIIDLLTLEETKKRVSTCIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7A0</accession>
    <name>G3B7A0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_98799</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7A0"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_1_1"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="255" mass="28696" checksum="9D274281C8D86B92" modified="2011-11-16" version="1">MWTRTYSRHVPLSKDDVAVVVGGARGLGIEMVKQLTNKYKVKKVIIIDMNKPEVRHQDITFIPCNVGDKKKYAEVLQNVIDECEASGDKIRVFVTNAGIRHSKSVLQLSMEEIDEIYDVNVFSYIQGIRALLKHHMKHPQDSLSIVTVSSVLGILAPRNLTIYSSTKAALSQIHEGLAQELVDFPSIRMLLVLPGQLSRGMFDDDIMDRVNNGQCGVLSEPIYGKLLPVVKCLPYSIIQLCRRFSQMDQKVRDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7K8</accession>
    <name>G3B7K8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_108003</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687810.1">
        <property type="nucleotide sequence ID" value="XM_006687747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7K8"/>
    <dbReference type="GeneID" id="18245997"/>
    <dbReference type="KEGG" id="cten:18245997"/>
    <dbReference type="eggNOG" id="ENOG502S2V3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1120501_0_0_1"/>
    <dbReference type="OrthoDB" id="4083086at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="231" mass="27248" checksum="AA172955B8507D80" modified="2011-11-16" version="1">MTNHTDSEPQRRPNPKGWTQPKAPYNPYDPTDVRPPEGYPSEFSIPGNAPSGFSSIPKEATQYKKVNQTMKKLNYTPRPLSEVYPGQYKVLRKIDTYNRLNIGSKWFGTFLTSTLVIYGLFFYRWNDGYENVTSDFYRARLRLKETMLRLTDEEYNDLYYPKGSNIVVKKVRDTDYIPEDIRRTKEGSMALNRPAERHVLEAQRIQQQREEAKLREDSAVVEKKKSKWWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7R8</accession>
    <name>G3B7R8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARID-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_108647</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7R8"/>
    <dbReference type="STRING" id="590646.G3B7R8"/>
    <dbReference type="eggNOG" id="KOG2744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2043601_0_0_1"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="4">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="121" mass="13563" checksum="19652AFF3B63A695" modified="2011-11-16" version="1" fragment="single">MAQLQMELFLVTLYDFMTRRGSPITSPPVINGKKVNFFLLYVMSQKLGGPQALIKALQKLGSGQSPWTAMAYKLGLYEGLTDPNAKGRVDKELGGCYVQYLIPFEQHNSTPAGHKEIQERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B830</accession>
    <name>G3B830_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_126120</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688507.1">
        <property type="nucleotide sequence ID" value="XM_006688444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B830"/>
    <dbReference type="STRING" id="590646.G3B830"/>
    <dbReference type="GeneID" id="18249149"/>
    <dbReference type="KEGG" id="cten:18249149"/>
    <dbReference type="eggNOG" id="KOG1993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003886_0_0_1"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="982" mass="113970" checksum="FEE893650CEC149C" modified="2011-11-16" version="1">MHLSEENLVSVLSTANESERSAVQNEAEAQLKQWEVQSGFYYSLQSVYLNTDLALQVRWLAIICFKNGIDKHWRPTRLHAIAKDEKQRIKARLFLLMNEKNNQLSVQNAHSIARIVRFEFPADWPDLFDEIHKSLEEFVFVKNDLTSTNNLLIVLNHIIKTLSAVRIGRSRHAMQSKSPIIIPLLVKLYNKFFQSWTTSLDLGIMEICYLVLKNLRRLIPESYEEIHKHHEVSDFLKVSVGHLEMLISQHDRYSSDLIERYAKCYSKLYFNIININPTTFILMPCSNDIVTFFFNYLNSDAEKIYKGTEDDNFWETIALKGFLILKKLITYIFKKGAITLKQPKDKQDIVNAVEKLKTQFFNVQVVQQLCDLIINWYLLLKPSDLESWLLEPEEWCNEEFSSSWEYQIRPCAENFFQDLIKYFKDDLSEYLFNKISSNLLGANKNILVQDSILCCFQLSADSIADKVDFNQLLREVFIPLALRNEDVEDKIIKRRICLIISEWVKINCSKESRVEIYQLLLTFISANDKIHDQVVKLGATQCLRTIVDDWDFDKRDFSPFLTAYVDNLIQVLQQMNFTESKLYILQTLGVLVERCNPLISYETLMALLNIIPKYWEISNSANENILKNSLIRILKSLVIALNENSLATHSIALPMIRSCCMENSDNYQLLSEDAYDLWHSVLQFFPNSSSSESKSTVDELFEMVNFGLMNSTEVLQSILSIVRSYTLLSPEIFTNRSVTDLLRILSGYLNTMRDDSFDEFIALMDILFLQNSKNEAFLKAMIDSGLVNSMISIVLDENQSIVKANEILLVLSRLAYSSSDFFLEMLGYLSNNLSNFLTTWIKYYINNGSARNKKINLLAFLALLNTSIPKKNEFFIRLFPDVVNNVLLFLEEIQETSLEKVYNSSLIYDEHRYLDPDIKENGEKIRYISLLQRADPVFNVNLKAYLVESINLLKSSLSPQEFNELLSLLDEYSVEQLQKFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8C6</accession>
    <name>G3B8C6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">CANTEDRAFT_108379</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688534.1">
        <property type="nucleotide sequence ID" value="XM_006688471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8C6"/>
    <dbReference type="STRING" id="590646.G3B8C6"/>
    <dbReference type="GeneID" id="18246023"/>
    <dbReference type="KEGG" id="cten:18246023"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_1"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000093">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="171" mass="20000" checksum="EC846484ED47BCE2" modified="2011-11-16" version="1">MLPQPLDLQKWIRENEDLLQPPVNNFLVHRGGFSIMIVGGPNARTDYHINQTPEYFYMFKGTMILKVVDDGEFKDIYIKEGESFLLPPNVPHNPTRFANTIGLVVEQDRPKDLLDKVRWYCRNCKEPIHELEFYCYDLGTQIKEAIINFDKDIDARTCEKCGTLNYSRPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9A0</accession>
    <name>G3B9A0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_107251</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9A0"/>
    <dbReference type="STRING" id="590646.G3B9A0"/>
    <dbReference type="GeneID" id="18245940"/>
    <dbReference type="KEGG" id="cten:18245940"/>
    <dbReference type="eggNOG" id="KOG3172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099537_1_2_1"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="108" mass="12129" checksum="FE16745C7F12E91E" modified="2011-11-16" version="1">MPKIDIPVRLLTEAQGHIVTVELVTGDTYRGKLLENEDNMNLSLYDVVITKGRSGTTSHMSQVFVRGSMIRLVIVPEMLKNAPMFFMKPSDKPKPPVRGPPPKRVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9H6</accession>
    <name>G3B9H6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_94765</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9H6"/>
    <dbReference type="HOGENOM" id="CLU_1660504_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="159" mass="17953" checksum="EA4B88B52DBCE18F" modified="2011-11-16" version="1">MKPTKKSARAFTSLENPTMKPTKRLARVFPEIPSENSNVNYDTMNIIEVTPLNSATPKQFLVPREIGEQYMQMKGCISRISEENAELRQQILLYKQQNALGSKLYIKSPPVSPSVQRNMYSVSSVQPLDFRSSSNQQIYGIPPTIIYVPFVPGDYPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9K5</accession>
    <name>G3B9K5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115360</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688084.1">
        <property type="nucleotide sequence ID" value="XM_006688021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9K5"/>
    <dbReference type="STRING" id="590646.G3B9K5"/>
    <dbReference type="GeneID" id="18247836"/>
    <dbReference type="KEGG" id="cten:18247836"/>
    <dbReference type="eggNOG" id="KOG3278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090033_0_0_1"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27771" checksum="CFE0DEC9CEAF04C7" modified="2011-11-16" version="1">MLTFTRGLTTGSRLFAPDKYYKITRYAKPLSKVSYKAGDVIPADRKVSIPPNKRHYPLYEYETMFFKSQNRGLYGGLQRTSSRTCSESGNKNLRSHKPNIVSSSIYSEILDKVFKVKVSTRVLKTISKEGGLDNYLLKDKPARIKTMGKVAWRIKYDIMKKLESDSLPVIEGKRIYLAYKGHNVYVGKNKLLSYLFEYAKRDTYEPITESQFLATNSWKDIKEVCQDLEKYSFDFKQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9X6</accession>
    <name>G3B9X6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_109600</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9X6"/>
    <dbReference type="STRING" id="590646.G3B9X6"/>
    <dbReference type="GeneID" id="18246124"/>
    <dbReference type="KEGG" id="cten:18246124"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="331" mass="37867" checksum="8A5DE544E76DBF19" modified="2011-11-16" version="1">MSYSFPFPTPDTPFGVKLFPYFDWLVSKITGGELVPSKFEFIAGEVPLSTGKPVLAAIATYYLVIFGGDFIFKKFKITPFVLNGPFQVHNVILTTASSTLLVLMVEQIFPMIYYEGLYYAICSAKAWTQELEVLYYFNYIFKFVEFVDTLFLVIKQKRLTFLHTYHHGATALLCYTQLTGKTAISWVPITLNLWVHVVMYFYYFLAARGIRVWWKEWVTRFQILQFILDLGFVYFATYNKIVDEFLGGSLPYCGSCTGEMSAAYMGCGILSSYLVLFISFYIDVYKKKTTRRSKRVKSVSGGVAAQVNEYVHTSARDATPVPESKVRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9Y6</accession>
    <name>G3B9Y6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_107542</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9Y6"/>
    <dbReference type="STRING" id="590646.G3B9Y6"/>
    <dbReference type="GeneID" id="18245961"/>
    <dbReference type="KEGG" id="cten:18245961"/>
    <dbReference type="eggNOG" id="ENOG502R9EV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61673" checksum="D02E39FF9127BFD1" modified="2011-11-16" version="1">MLLSPITSIESYNQTISKALIPDESDARRLTSINDLPLEILMKIIGYVYFDSDNFDSIYKLLESFTKLGLVSKLFHLLSVKYLYKYAAFNRPHAFHKFLINLQNNPNLGKYVQFVDFETFTSIGLGRTGKMNQEIQMVTSRTIFTSLTKTPNLIEFLASENIQDDMNVDVLNYLFNELPNLQSLDFCGASSKAFYEAFRGLTIDKPLKKLFKVSFHDCSNLSVDIFEKILPHLVNLRRLDLTHTSVNSSLLLNYLPNSCNLTHLSLSRCSKLTTRDLINFLVNHPSVANNQLQWLNLSVDSNVVTPLNSNYLFFTLKHMNASNLQYLNLKGLPITEKLLTLINMKFQNLKTLSIAFSSIDFEFLFEFLLSTPCLAHIDLTGCKLTKAQILQLITIPHLSSLECESQTLKDLTNNESQFIRRDSLVWRFHDNNGRRAWIYRLESTDDQYKQIQQFGKILNLNLTYYDLNTGEKIVTKNLRPRFLKYVGKKINCSVGFQNLQCCKHKKYLNNSYDEDVWPGKFCETGIYNYYSLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA15</accession>
    <name>G3BA15_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_125404</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA15"/>
    <dbReference type="STRING" id="590646.G3BA15"/>
    <dbReference type="GeneID" id="18249102"/>
    <dbReference type="KEGG" id="cten:18249102"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017390_1_0_1"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000047">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="52"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="143"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="281"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="372"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="522" mass="57746" checksum="D359D32EF7F6CC25" modified="2011-11-16" version="1">MVYPPPHMQGQVEYQGGYMGGSTPDMNMNSGMGLINGNSNSSVNVSNGAPSRTVYLGNIPNDIEPRELLDYVRSGILESVKILPNKNCAFISFVDHQSALLFHSDCILKKLSIKGHDIKIGWGKNTPILPAVLESIQRDGATRNVYLGNLSNPITGEMITEEELRADLAIYGVIDSIKIIADKGIAFIHFLSILSAIRCVANLPLKEKYLEKKCFYGKDRCAFITKTQQHNAAQYLGLAPGMEHIVTAADREFISSALVQQSAAAAQIATHAGGANNLGNRTVYLGNLHQESSIEEVCNVVRGGLLQSIRYLKERHVCFITFIDPIAAAQFFAMCQLHGLTIHNRRIKVGWGKHSGPLSNALSLAVSNGASRNIYVGNIIDFHYYNQEKLRTDFSKFGDIEQINYLEEKNCAFINFVNISNAIKAIDGIKSFDDYKSLKINFGKDRCGNLPRQFQQSNMQFNQLSQLQLNLNEQYLEQSKRKSQSNSLSSKMTPPSTSESHSRPANTPSPSPLPRSVSNHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA46</accession>
    <name>G3BA46_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115472</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA46"/>
    <dbReference type="STRING" id="590646.G3BA46"/>
    <dbReference type="GeneID" id="18247886"/>
    <dbReference type="KEGG" id="cten:18247886"/>
    <dbReference type="eggNOG" id="KOG3195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074845_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="226" mass="25535" checksum="8DEEE4908AB97E35" modified="2011-11-16" version="1">MSEYTPIESDVSNNRGPAYTDTATGNMGTAPSNTSEWTWAQKLKESSHPVALLAFLFFRIAPMFVYIFGNFFIGFITKKNRFILHFIVLILLVTADFWNLKNISGRLLVGLRWWNEVSQTSPTSGEFENVWVFETADPNRYINPIDSKVFWFLLYGQPVGWLLLGVLAILKLEFLYLILIIITITLSLTNAVAFTRCDKFGNANNVATSIFSKAAGSFVSRFNPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA95</accession>
    <name>G3BA95_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_108969</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA95"/>
    <dbReference type="STRING" id="590646.G3BA95"/>
    <dbReference type="GeneID" id="18246075"/>
    <dbReference type="KEGG" id="cten:18246075"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF423">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PPQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="215"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="403" mass="45412" checksum="65D769E025020BFE" modified="2011-11-16" version="1">MSPVFTSLEYKDSDSLSSLGSFSSSPKATSFQYETEGIIGNLDPISESSENSPTPDEAIKVTVQKLSQVTLASSSSSDVSPPLTPVSRRGSYPVDIDAIITRLIKIGNDKPAKKSKLSRDKLPFTSEEIKYILNKSRSIFLDQPTLLRLAPPVKVLGDLHGQYTDLIRIFNKCGYPPHSNYLFLGDYVDRGHKSLETILLLLCYKIKYPENFFMLRGNHESANITKIYGFYDECKRRLPSLTGNHKMWKMFVDVFNSLPIAATINDKIFCIHGGLSPDLHNLKQIEDIKRPTDVPDKGLLADLLWSDPDPSVKNFSLKNWPKNDRGVSYCFGRKHVDHFCATFGFELIVRGHMVVEDGYEFFDKRKLVTIFSAPNYCGEFNNYGAVMSVDRSLCCSFDLLKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAD1</accession>
    <name>G3BAD1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair and recombination protein RAD52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_94913</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAD1"/>
    <dbReference type="STRING" id="590646.G3BAD1"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111192_0_0_1"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="180" mass="20039" checksum="4D9BC9BC41FCCA8D" modified="2011-11-16" version="1">MSEYKFVLNNTGHIHLPEIEDFLRSEDEEEIEDLTPLLKVASLWGQSKIGTLQARLEMLQTRSTNKSYELPNHRIMSLANEVFGFAGWSTSLSSLEVKEQVDHCQSSIPGDATEYNVTAWAKVLITLKDGTVLESSGKSNVQKFPDKGMAYRTAKMSAVTNAVKTGIMMLPVLAVENEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAK9</accession>
    <name>G3BAK9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_124102</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAK9"/>
    <dbReference type="STRING" id="590646.G3BAK9"/>
    <dbReference type="GeneID" id="18249003"/>
    <dbReference type="KEGG" id="cten:18249003"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="438" mass="49904" checksum="80BFCA5CBD30C634" modified="2011-11-16" version="1">MGVDDYELEAFAGRGAFGDVYRAHSLKHNTIVAIKVINLEETSDDIKTFVSEIHFLSSLRSEYITKYFETIVQRTTIWIVMEYCGGGSCYDLLRCHKKFSEEVTAYIIRDVLRGLSYLHNQKRVHRDIKSANILLSSDGKIKLADFGVSGEITMTHLKRETFVGTPFWMAPEVIAARDMGHDQKADIWSTGITTIELITGEAPLSGQDPRKIIFDIPRRKPPVLTGINFSENIKNFVKYCLVKDPKNRPSANTLLHHRFITGVRRHVNIIQLIKEKDEWMKTSKRKVRRPRNELQLDETTTSQMINWNFDSTRIGAPSIVSRKVSPMALDSLELSFDIPFKSSSELSSPETPLSSGQIQNDHLPSDQLSPNSSPQPAYTYTSCFFYCMKRVEERANLPSTKRAVGELIKDLVLYENDQPGICYAIFEEILKFKHVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAS0</accession>
    <name>G3BAS0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1765-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136029</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAS0"/>
    <dbReference type="STRING" id="590646.G3BAS0"/>
    <dbReference type="GeneID" id="18249931"/>
    <dbReference type="KEGG" id="cten:18249931"/>
    <dbReference type="eggNOG" id="ENOG502QPNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005190_0_0_1"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="963" mass="110399" checksum="C4A319CCC910B98F" modified="2011-11-16" version="1">MTTSGLLQKNMDRSRSVSSHNSTSSLNTLTTPKSRRARLLDELSVPTPSFMDNDKSIKLMLKHFKRLELGLNKFNSKSDGIATTNILRTVLLPFLRSSSLNSLLVGISTTIGYKVYKSLVSILSSILIKWWTSLLNSLINSHTLSSIDRSAYLECISRIISRREWFHLEDGLVDAITVKAHDDILVLTLDYSIWKLASIKHLPLSICAFVGKVFAYGFFRLEGVSNALLFLLNIKQSVFEENRRVFRRHTQASPDDLTQLYATFPKHLHYLVGFDGLQNKDLSKHQKIFLNCLVPPKKEVPGIKDPNGLWVGRWLNSDSDIFNSFLRHYLHILHSTYSINNPVVSDGMLLNSPGLNIIMTHLFQILQISVSRISKNNSNLKINQDFQVMQKLSSSPAATSAKSNLQKQNDVFYNSVFKIFRTLRDLKFSLHLESATCDDKFMNSMIGYVEMILKSFASQMTIYEFNKSSLILNIIYEFVNSLGVIDWTFWLNCCHLMIENTDHIQILLKNISFLFNVWDKIPEIVPQVGANTGNIKWFSDCNKSFKVNFIGWLISSNIWEKFFLHWNPLVRNYYLRLLIWQVVGINNFESSTSIEISLEIQHKLDQSYATFNNFYAKNHDKNHYFKPDNPVINRKMAILPITKDEYLLNEITNQGDDEAGDLTNLFAPSELKKTHPFEIFDEAIYSCSSLPKEEDEDTSKRSNSLVNSIGKIFKMLTVDDSDITKEKKPSKIREFRSSSKSGSLTSLSTYSLKSRSSSPSIMSYNSSPTSLTDFSESSSSITTVSTVPSESADRLKSFTLPPEIVRPAYKFELVLDQNSIRDKHFLMANKNYVFRNHDYFKLPPTPTVPSISIYLQSDIYKKFYISTENYFLLVDDNQKSVFENGLFDSLDKGKSINYINLGKSLFEWSHLVEEFESYLINKVEVDQFNENITSNHELNEHDYFRKIIPLLSLDSNSKPLNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAS3</accession>
    <name>G3BAS3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_99174</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688267.1">
        <property type="nucleotide sequence ID" value="XM_006688204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAS3"/>
    <dbReference type="STRING" id="590646.G3BAS3"/>
    <dbReference type="GeneID" id="18250835"/>
    <dbReference type="KEGG" id="cten:18250835"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="294" mass="33041" checksum="671A23DA606CC1EF" modified="2011-11-16" version="1">MTTDSVEPHIAVLLCNRRDSRLVDKYGDLGDLCCQLVQNSGVSKFPGKKYTVYRESDDPNEDSIELSRVYLELVERIEKKLVKGIIISGSVSDSFDTKLWIQRLDEFLRTVVFSIPNFPLVGICFGHQIICKNLGCKVDRNLPEVGWECGINTISLNPEIFSIENNGFLDILKDKEIGVINDHLNLPEIHRDIVYGLPAAQNSYIKGTNFVSIGSSPKCSIQGVVTASGPLRVLTFQGHPEFSTEFTLELLKDMYEKGTIEKPVFEKSCYNTQILNNQGHLIAKLICNFINSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAS7</accession>
    <name>G3BAS7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_131520</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688271.1">
        <property type="nucleotide sequence ID" value="XM_006688208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAS7"/>
    <dbReference type="STRING" id="590646.G3BAS7"/>
    <dbReference type="GeneID" id="18249533"/>
    <dbReference type="KEGG" id="cten:18249533"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058492_0_0_1"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="234"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="383" mass="42062" checksum="5CA4BBC1B18C3DE6" modified="2011-11-16" version="1">MSSETHTGTKRSLDTGDGDTKRLKPEPGLSTSTDDLESLKQSIKAELLASFEDKFAAIHSELNDLKNKYNSLIKPNPPPLPPRDTSTVATAPTFGAVSKPPVLNRVSENGTPELSKPKHTFGGTSFDFKPAVATPTTSLADENRVTDTPKDKSDGSTNSTPGKHVFGATTSFGNASVLNKMAERKNVFADLPSSASVNAGSASSFGANTKFSNAFRNSTAKKSFLDEEPQKDSEEEPQDGQPSQQYKQVDLEPVKNTTGEEDEKSHFNSLCKLFELDFEHMKDGWKERGLGQIHLNQSIKDPTQVRLVMRSHGLLRVILNSKITKNTETHKGLEASLTPGKFFRFNAVNECGQPVQYLLKFSNEGLRDDLVEKIENLKDQMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAZ4</accession>
    <name>G3BAZ4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_131052</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAZ4"/>
    <dbReference type="STRING" id="590646.G3BAZ4"/>
    <dbReference type="GeneID" id="18249494"/>
    <dbReference type="KEGG" id="cten:18249494"/>
    <dbReference type="eggNOG" id="ENOG502SDE4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105987_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442892" evidence="5">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="176" mass="17408" checksum="961C72F52CC5A462" modified="2011-11-16" version="1">MKFSSAIVAAAVAVPALGAYTNSTSTVTDIATTVVTITSCSENKCATSVATTGLTTVTENDTIYTTYCPLTAETATETDISTTVVTITSCSDHKCATSVATTGVTTVTENDTVYTTYCPLTSAAATKAASSAAPTTLAAQSVAASSAASVASFEGAALANQVPAFGALLAAAAILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB29</accession>
    <name>G3BB29_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115592</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688961.1">
        <property type="nucleotide sequence ID" value="XM_006688898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB29"/>
    <dbReference type="STRING" id="590646.G3BB29"/>
    <dbReference type="GeneID" id="18247929"/>
    <dbReference type="KEGG" id="cten:18247929"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_413380_0_0_1"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="410"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="533" mass="61316" checksum="CF14B53531A98AA0" modified="2011-11-16" version="1">MDDQTLSPAKQTAVDEFIAITGSSDDNVSQIIRLLDVHNWDLNNSIVTFFESGFIQESSLPTPVEVDTSTDMPQASGVDYGHPGSDTSRVSRRYSMVDSPLDDLIPSLPYAPRISNHWQLEVGLNASKREVLRANNLRAINSLLFLLLFVPKKLLSFLYQVFKFIFKINTANYFPAAIDYESVDLDHKMPLSEYVDKYNIVEGNFNEVYEQCKTNYTWLLVVLVNGSQEASDLLSHLLSNHHFEKHFNKANHTDNFTTCIYINDVEKNPESYEVGRTYKVKRLPFVMLINNVSNSPHKLPSMSITYKSNLPSVLLQPSQVGSTANKVAIYLGRIISNYQPQVVAAITDKREMEFARLIKQQQDDAYQKSLEMDKVKKAEKSKKLEDEMLLQQRRSFLFNLIKSRWFETLNPEPNTRIQVKLPHGERIILNVNNQNQLKHLYLHLESTLFPRHLAADDAEEFETASQVLEHISSNDFDCQISLEDYYKHFPFKFELIQPYPKKVVDDLEATIKEHIKNGASLLVEYTSDDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBC2</accession>
    <name>G3BBC2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_125746</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBC2"/>
    <dbReference type="HOGENOM" id="CLU_475645_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="573" mass="65377" checksum="4532B8970DDF87D9" modified="2011-11-16" version="1">MAFVFEGISQSAPTIPAYKETPQRIAELSVPETNGWAQPSVSSLSPDDSKESLLALIAYEAGFPSSTDASSGTYTDNDELVFDTDSAGGFSPFRSSDLSPNNLDETWFAPSTPLSYPDVWASSATMTLNSMMTHLNIDWFEYRLLTFFHMHVLESRFECNHFDISMRSQSSHAFIRSPTFRQVVYLYASFQLYSLCDEQKLETMGFNDMCLRLAANSENLGNLGTSSRTLVPHSNRVFKELLELLNGMGGYLEKDHGDNGVVTKGIVKSGQSVLYRKILEYFQSTLQSSYDQIMKLVSNPVLEVDEALSLILGNIFFFCFLFSQPFGFLPLYSPNDEPDIVGFVGNLRWAFIPSFYALEHGEFNKVLVFCELRPPKDADEFYGYYVFSDYPIVAELNRQLKQCFKDGTVSEPEFFSYRATLQKLDRSFLAMVDNNLASCIFRWLFMFRESVFGFIREGKFFAHKLLFYYSCLSYWTGIMGVRGTGVGAGLKCPVIEDYLQYYRQYIFTRFGKWDDPRDEASYNLVIKYRYVLSLVDVKNVVEFRPEVALRAIEQLENSGGDVQAFTKPEQTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBJ9</accession>
    <name>G3BBJ9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Membrane fusion mating protein FIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_108985</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBJ9"/>
    <dbReference type="STRING" id="590646.G3BBJ9"/>
    <dbReference type="GeneID" id="18246076"/>
    <dbReference type="KEGG" id="cten:18246076"/>
    <dbReference type="eggNOG" id="ENOG502QUDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075335_1_1_1"/>
    <dbReference type="OrthoDB" id="4089394at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27146" checksum="8865C766B1850024" modified="2011-11-16" version="1">MVNFAAKIPAVVLCICVFITNFLLGFLLMSCYTSTEAYSSLFLTRYQFNKKEMSIVSFNGTETTESDLSSFTLSIGYLSFCVSYDGSVSCTTFDNLGKLKTYPIISVDTGDKNTTIDLVKLARKFNNICYPYVLMSAMIMALACLALNAWISVPLLPGKLLVRKMIVGVSGIDAMVWGVGSMLQHQATKANQALVPSASMKLVQVKTGIRAEAVTWTAFSFLVVIALGNGVLLLRELRNQLKATSKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBL5</accession>
    <name>G3BBL5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115034</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBL5"/>
    <dbReference type="eggNOG" id="ENOG502SXTV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111194_0_0_1"/>
    <dbReference type="OrthoDB" id="4079690at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="160" mass="18063" checksum="B7AA63C4307905D8" modified="2011-11-16" version="1">MPPKLVDKRKQVTILKFKRGKSTYVVPIEFSTKSFQTLQNRLLDIINNSGGLTLSEDEPMMEDEDDIKVPKSEFIDEEEETGETDIKDAIMKDSPPPQTRIVKAGELAIGLPRDKTSPYSNDWVTVDDTILSTIEFNDYDILAFAVDGEPFNVVEAAYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBS3</accession>
    <name>G3BBS3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115689</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688992.1">
        <property type="nucleotide sequence ID" value="XM_006688929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBS3"/>
    <dbReference type="STRING" id="590646.G3BBS3"/>
    <dbReference type="GeneID" id="18247968"/>
    <dbReference type="KEGG" id="cten:18247968"/>
    <dbReference type="eggNOG" id="ENOG502S2H3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_882771_0_0_1"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="315" mass="35956" checksum="23EEE938551A5053" modified="2011-11-16" version="1">MVDLSSYKKAELLSVAHKVNVAANSKDTKKTLIEKIEAYISEAGTTGEELVEAGLEATDDDSEDDASTLIDPQPKETEEDDEEYKGPPIDVLKYFDPIIKCAEEKYQKVLEFTDKVGITTLEYNDELRENLSGTITLNYIELIFEFTYFIYTFVPLVAIKDNASIHPYLKNLIPFLSDITLKIPDLTYLFNFKVLSIALNWGAYAVLLPLLLSFYFNFSRRTILVDEDTSVLLRIYKYDPFIFALSKVLIFFFITYNTGSLSVWSSYSSLFKALQTHFLIQLGFYKEYTLLLGNFPLVLGIANVVIGLYAQFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBY7</accession>
    <name>G3BBY7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L35Ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_127006</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBY7"/>
    <dbReference type="STRING" id="590646.G3BBY7"/>
    <dbReference type="GeneID" id="18249209"/>
    <dbReference type="KEGG" id="cten:18249209"/>
    <dbReference type="eggNOG" id="KOG0887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100745_2_0_1"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="107" mass="12101" checksum="93F5E8C1E5341534" modified="2011-11-16" version="1">MAESHRLYVKGKHLSYQRSKRVNNPNVSLLQIEGVANPADAKFYLGKRVAYVYRASKEIRGSKIRVIWGKVTRTHGNSGVVRANFKKNLPPKTFGASVRIMLYPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCG8</accession>
    <name>G3BCG8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_110241</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCG8"/>
    <dbReference type="STRING" id="590646.G3BCG8"/>
    <dbReference type="GeneID" id="18246180"/>
    <dbReference type="KEGG" id="cten:18246180"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_1_1"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01582">
        <property type="entry name" value="Homoaconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000016">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="23"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="476"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV60832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="676" mass="73171" checksum="902257585AFB4BDD" modified="2011-11-16" version="1">MKVFFRQFSVTSARARGQNLTEKIVQKYAVGLPSDKRVFSGDYVSIQPAHCMSHDNSWPVATKFMGLGASKVKDNRQIVCTLDHDVQNKSEKNLAKYTNIENFAKEQGIDFYPAGRGIGHQIMIEEGYAYPLNLTVASDSHSNTYGGVGALGTPIVRTDAASIWATGQTWWQIPPVAKVELIGQLPKGVTGKDIIVTLCGLFNNDEVLNHAIEFVGEGVRNLSVDYRLTIANMTTEWGALSGLFPVDETLIAFYQDRITKLPQPHPRVNEETVGNLIKNPTHSDDDAVYAKHLTIDLSTLSPYISGPNSVKISNSLYDLSNQNIKINKAYLVSCTNSRLSDIKAAAAILKGKKVHPDVEFYVAAASSNVQKDAEADGAWQDIIDAGATALPAGCGPCIGLGMGLLEDGEVGISATNRNFKGRMGSKDALAYLSSPEIVAASAVLGKIGGPEELEGKPVAQNREITKQVTVPKAETTASAEDGGAVDILDGFPTEIVGELILCDADNINTDGIYPGKYTYQDDIPKSKMAEVCMENYDSEFRDKVHAGDIIISGFNFGTGSSREQAATAILAKGMKLIVAGSFGNIFSRNSINNALLTLEIPALINMLREKYKDSKELTVRTGWFLKWDVTKAMVYVADSDSNIILSQRVGELGTNLQDIIVKGGLEGWVKSELAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCS0</accession>
    <name>G3BCS0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_100173</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCS0"/>
    <dbReference type="STRING" id="590646.G3BCS0"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027112_1_1_1"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="194"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="306"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="351" mass="39061" checksum="8C7304A20CABAD1A" modified="2011-11-16" version="1">MSDIEVPTLCSKCLGKDPNVRMIKQPQGETCKICTRPFTVFRWQVKDGSKRSKNTMICKTCARSKNCCQCCMLDVNFLIPTEIRDTALRMAGLGHLVTQQSDTRNLEVKAIIADKQQAQFEKQDKETLENNEKARQILSKLASQVNETSIEASPMRKASKSARTPDTSIPAGLSKVIKRLPFSGSIQSSEKELTSFFVFGIPEDCPQYEMSEYFEQFGKIRLISIIHKAKCGFVSYTSRQSAENLANSVSENGLNKNRSTPGLLLLRKSIPVRIAWSEVKQLGISSSEHKKIALVVNKVMEQLAEKDSKVSKGASKNPHSINQSKQASKSTAAKSKPISTKYQASQPDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCY1</accession>
    <name>G3BCY1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116288</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCY1"/>
    <dbReference type="HOGENOM" id="CLU_2512405_0_0_1"/>
    <dbReference type="OrthoDB" id="4096434at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="85" mass="9951" checksum="40F1AC1739609D5C" modified="2011-11-16" version="1">MYVYKQEQTQDLGKSRTNPMEDPMYGFCVTIADADSRCIPFTKEADRCDVSDCNTRLELSSKHNWKPKERLLVRIVQLLGSRIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCY7</accession>
    <name>G3BCY7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VID27-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_127272</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCY7"/>
    <dbReference type="STRING" id="590646.G3BCY7"/>
    <dbReference type="eggNOG" id="KOG2395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007002_0_0_1"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="244"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="425"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="777" mass="88210" checksum="8E3FF19A4E8302CD" modified="2011-11-16" version="1">MNFIRKFMGKSSTEELSSVPKGKLYLTRAPNSPKGSLECLYNDAFMCIRSTTRPFYYQLAVSKVYQEGEILTPNDNEFDDNEWNFIILQDLSFKFIEKKNGSMAISWIDINGDVGDSFEFVIDDDVNLNDVESFKISLYKCIYESKYHKPSTEIDETELKEFESFEEELTLEDNVTTYDDEDDDDDDDDDDDDEEWAETSQGIVGKKSKSLGAASQQTERPYGDDEESTVVFIEPATKEEPKEKVFSKKVDLYLYGEDGFGFTSEVTLEILSYVAWNYTVKLYNGSNVRFETFLSSAMSPIFEESKNAFVFNYNRASESGLQSSTWLVGFDKLATMKEFQNQFLKCYFEYTNKKKYPDTEELDSSYLADSLSGMTLDDDDEFFSTHSSSDDKESDEDDEDEEVVVRPARSAKKITVPANVEGGINSDLTVGFANDRSYVVNGNNLGVFKNGNDDLEFQSTIGGLKNRAGQQILPEALMLQRRDESLVFKDKNSQGLYRMDLNRGQIVEEWDVSNNDQALRHFTTNKKYDQLTNEQTFMGISKNEVFQMDPRLANIIVPTETRLKQSNFNHINTTKGGYFAVSDADGKIRLYDRIGLKRAKSLLPSLGDTIVAMDTSNDGRWLLATCSDYLLLVDLKVQAGSKNAGALGFEKPFSAASKPIPRRIMLKPEHSMAILNSGGQKSLNFTRAYFNTKVTDHAETDIITSTGNYVVQFNLKKILQGKVDSYVVKKLDEAVVSSNFQFGSNNAIFASEHNVAKMGKRKFERFERFEKASERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD73</accession>
    <name>G3BD73_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116317</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD73"/>
    <dbReference type="HOGENOM" id="CLU_2922412_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="61" mass="6741" checksum="AC728A41C349F5D7" modified="2011-11-16" version="1">MGIRKLWDFDVSNTAVFIGWSATSQEVKMIVVFFGSGGFKSRIKLTHQYRQDSPSGNGISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD85</accession>
    <name>G3BD85_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116324</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD85"/>
    <dbReference type="HOGENOM" id="CLU_2757552_0_0_1"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031459">
        <property type="entry name" value="Coa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17051">
        <property type="entry name" value="COA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442848" evidence="2">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="70" mass="7926" checksum="0377D838EE0416DE" modified="2011-11-16" version="1">MYFAVKGVPKNLFSSTFAVCFTLVAANSLLPCPVDTNYNNDSNLDPKLKNQQKHLAPYKYSQQPERSQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDZ7</accession>
    <name>G3BDZ7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_95871</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDZ7"/>
    <dbReference type="GeneID" id="18250554"/>
    <dbReference type="KEGG" id="cten:18250554"/>
    <dbReference type="HOGENOM" id="CLU_2084567_0_0_1"/>
    <dbReference type="OrthoDB" id="4008139at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="117" mass="13654" checksum="1FA1277268616106" modified="2011-11-16" version="1">MFEPLSEMPESSSKSEFSGEYIWVNEWHKLQDPSLRKIIRHGTQLKSWHKVPKNNDSPSGLDLDANSVLDLKNLKYYEEVPIVDHSKKKIDEIESREHEMNGDSDVKVEKREMGDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEP0</accession>
    <name>G3BEP0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEP0"/>
    <dbReference type="eggNOG" id="ENOG502T2TV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041160_0_0_1"/>
    <dbReference type="OrthoDB" id="4022842at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="479" mass="52523" checksum="6FB5D34C0FF3D14C" modified="2011-11-16" version="1">MAIATASSDAFGNIRLTPRLRAACVPVKANGKNAFVEVLSKGLESDINVPTLIFHIKDLENFSSLPLPDTIAAAPAGSVASDGKFDVSGSVGEDKYLNSYLVGDSKDEHFKLHFDVTDSGLYCVYVDPAADVVSYDLPIIVRNSYGYLNFYEYIEVSESRWGLLLYIAVTAWLLRDLIRSVGKDFSNLNNISVVSKSAVFLILMPYIGIMIMTLASDFILNCVAEKGFLSVFFRSGISIFSSLYQVCISIMLLLFCMGYGVVFYHRQTKSYRQLPAPKMRMAKILGGIQLALVCVNGMFMVFASNPSSDLAAGSANSFPVVEGALVLFQFILYTTSIIQGVKTLRNIKEFPPYGSSVEDYGEKNEGIRVAFKRSLCLIFLVPMLFGVGAGIIAGVSGGANFIQDFGPNVDPALVSYLTLDMLIKDSTFLYFQTWNMIVTTLVVIIGVFFIWIKGNQGLVVDDKEYFEAPAYGDSDPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEY6</accession>
    <name>G3BEY6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115993</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690180.1">
        <property type="nucleotide sequence ID" value="XM_006690117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEY6"/>
    <dbReference type="STRING" id="590646.G3BEY6"/>
    <dbReference type="GeneID" id="18248115"/>
    <dbReference type="KEGG" id="cten:18248115"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="268" mass="28185" checksum="49B0D3D1AE4C2863" modified="2011-11-16" version="1">MVDFNVQGKVAVVTGGTRGLGLYCAEAFVLNGASAVVISSRKQKACDESKKYLEKLAADNGKTCRVIGIAADVSKESDCNLLFEETSKHFKKVDILVANAGATWGAPIGDHPISAMHKVLALNVVGVFNCIQLFTPLLEEAGTPEDPARVVIMSSVASIVSLDAAGVYGYTASKAGVSHMGKSLALQLGPRNITVNSLAPGYFPTKMANGLIEVAGDILVDTNPRRRLGEKEDIQSAILFLCSKQSNYINGVVLPLDGGTHLAPGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF16</accession>
    <name>G3BF16_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116014</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF16"/>
    <dbReference type="HOGENOM" id="CLU_2978919_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV59987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="58" mass="6825" checksum="82A7A66E1C723BAD" modified="2011-11-16" version="1">MRLPHTAAGARRRTPESHTASVKMRIMDSVDFHAQALARHLTHRQQFYSIYPTRDENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF52</accession>
    <name>G3BF52_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_132347</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF52"/>
    <dbReference type="STRING" id="590646.G3BF52"/>
    <dbReference type="eggNOG" id="KOG0213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002242_0_1_1"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="9">
        <location>
            <begin position="747"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="969" mass="109630" checksum="6145FB85487C4A67" modified="2011-11-16" version="1">MPKSIAAELLREYERDDSSTSESIKETIKSSYNKQSHILTDTLNRRKRWDVTPEEREQLLKAEAEQAALEKSTEPAKQFYEPLGDNEENKKQIEQSIVVAPEIKGLEFYNNTDDKYFGDLKVLQQKKILTGDEKIDVKVMELLLKVKNGNQAVRKRSLRALTDQSKTLGPSTLFKRILPLLIDDTISDQERHILVKLIGRILFKLDELIKPHTHQILVAVSPLLIDEDQTLRLEAREIISNLAKAAGLATILSALRPDLSSNDEYVRNIASRILAVVANSLGLANVLPFLKAVIKSKKSWQTRHTGIKIVQQLCLQLGAGNGTSILPYLQQLVELLSATLSDEMLQIRSISAIAVSQLAETVAPYGIEYFEPVLEPVWAGIKRHRGRALSTFLKCLGSIIPLMAHDANYEEYSNYYTREIIAVISREFSSQDDEMKSSILKILQKLPLSRQLIRDYEKQLYLPFIRYYWNRRTAADMKLMYRLVVNASTELALKLDYLLMVERLILYTKDENEQLRKMAVESIAKIISAKPEELIGSDQKFEEQLVDGVLYAFQEQTTFNKVYLNGLATVCNALGMRLRPHINSILSTVLYQIKNKSPDVRKQASLLIGAIAPVVKLCTEGESETLQKLILILYESLGEVFPDVLAGILSALNACLDSFDADDLVTLSNPSIPQLLPSLSPILKNRQEKVQESCISVVGLIARKSAEVINVREWMRICFDLLDALKSPVKRIRVAANRTFGEIARTVGPQDVLTMLLNNLRVQQRQLRVCTAVAIGIVAEVCSPFTVIPAIMNEYRTPDNNVQNGILKAMTFLFEYIDGNLTKDYLYAITPLLQDALTDRDQVHRQTAATVVKHITLNCEGCVTDAQIDVFVHFMDLLMPNIFETSPHVINRILEAIDSLKNIIGYGRYMNYIWAGLFHPARKVRASYWKLYNLAYVQSADAMVPYYPKLHDIDDVGSSYAVEEFDLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFD2</accession>
    <name>G3BFD2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_136532</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="9"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFD2"/>
    <dbReference type="STRING" id="590646.G3BFD2"/>
    <dbReference type="GeneID" id="18249980"/>
    <dbReference type="KEGG" id="cten:18249980"/>
    <dbReference type="eggNOG" id="KOG0354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002513_1_0_1"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="140"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="468"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="698"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="778"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="797"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1038" mass="116731" checksum="6DCEDD5637415230" modified="2011-11-16" version="1">MSDDDFDDELDLMLSKASATVAVDSIVQQAPNSPPASSGLSSGSFGEGISQISTISRGDSNQLQSSRPGSKTSSSSKQQRTQRDLFGNVVSSSQSTSDTQTSKRSDMAKEVPTHHELDYENLKSYIYPINYEIRDYQFNIIEKCFYNNMLVALPTGLGKTFIAATIILNYWRWFPNSKIIFMAPTRPLVAQQIKACFNIIGLKDQSAVLLDKTKRNRLEIWNSFRIFFTTPQVVENDLCNGLVDPKSVSLLVVDEAHKAKGNYAYNNVAKFLDRFNNSYRILALTATPSSTVEGIKEIVGNLTINKIEIRTENSIDIIKYFKHKRIDKIDVDFNDNEVITNCLIHTANAAEPYIKMANERHLFQSSDPNDLYMFKLLEITKRNLLNNNLSEGLKWQNHFLLKLLLFKANCIKKLKIYGFNNFKAYFNDTRTKVLASKNKMMLELFSSAPVKELVGYLSKTQVQFGHPKIEILIEYINNFFKTSEYDNSKVIIFSELRDSALEIVSTIEAMNNPRLKPHIFIGQAPDSNPEVVDKQNGGPKRSSSEDAKLKGMNQKVQKQLIKDFKTEKYNILVATSIGEEGLDIGEVDLIVCYDTSASPIKNVQRLGRTGRKRDGNILMLFSDNERSKFDKAMDNYEWIQKFIVRKEAELVQDCTRVRIIPSGFRPALEKKFIVPEEIEVDDNDEIIKIAMSYMNKKTKGGSVTKASSKSAANKTKSKKSKGVEKIEKRFFMPDNVESGFRNVTDMLKSVDKNKRARSPPLSQELIDTSFMSDASFNRTSEKENVVEIPPVKSAPVKSAPTKSAPTTSAPTKSAPTKSAPTKSATESVPVKSAPVYQVLRASQKSLGTKKLKLESGATSTQLPQTDISPRGVAASKDETFSDFDDFDDFDDFDDFGNEKLSVKQVEIITFTKETPVKCGLGVDNPMETASAPDSQDDQLVDNRFHPQDGFLSSQEKVQLYTNYYNPIPPDIKFYDPIHSSCSQLSSTKTKRFNETMKNMDTLTAKKAQTQLKSYIEMVKGSDTNSRASCIEYLNTHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFF3</accession>
    <name>G3BFF3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_100036</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFF3"/>
    <dbReference type="STRING" id="590646.G3BFF3"/>
    <dbReference type="GeneID" id="18245354"/>
    <dbReference type="KEGG" id="cten:18245354"/>
    <dbReference type="eggNOG" id="KOG0372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="307" mass="34882" checksum="282FDCC0870346C1" modified="2011-11-16" version="1">MLNLDDTIERVKECKLIPERDVEELCNKIIEILIEEGNVQALDTPITICGDIHGQLHDLLTLFKTGGECPSTQYLFLGDFVDRGFYSLESFLLLMALKVRYPDRITLIRGNHETRQITTVYGFYDECLRKYGSVNVWRYCCEVFDYLSLGAMIGGQDGVFCVHGGLSPMIDQIDQIRVINRKQEVPHEGAMCDLLWSDPEDVPSWSISPRGAGFLFGYNEVKKFSHTNGVSLIARAHQLVMEGYKEMFDKRLVTVWSAPNYCYRCGNIASVLAIDNALGRQYKVFEASTNQEISSIPSKKPTIDYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW10</accession>
    <name>G3AW10_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112156</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684015.1">
        <property type="nucleotide sequence ID" value="XM_006683952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW10"/>
    <dbReference type="STRING" id="590646.G3AW10"/>
    <dbReference type="GeneID" id="18246377"/>
    <dbReference type="KEGG" id="cten:18246377"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_0_1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="240" mass="26966" checksum="F078D8CDC2FD6FEC" modified="2011-11-16" version="1">MVPSKFKACLFDMDGTLLNTEDLYTEATSDLFKEFGKGPLTWDVKIKLQGLPGLEATKIIIDHYQLPITAEEFAKKAMEIQATKWHRANYLPGAFEILAHLKQNGIPIALGTSSNKLNFERKTNHLEGFTDFFGDHIVTGDDTRIPKGKGKPEPYIWYVCLGSLNEHRKSQNLEPIKPEECLVFEDGIPGVLSGLAADAHVIWVPHPEAHAYIGPVKEKLAGRKMQILNSLTEFPIERWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWH8</accession>
    <name>G3AWH8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">inositol phosphorylceramide mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.370</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_100431</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1&lt;-&gt;6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:155885"/>
            <dbReference type="ChEBI" id="CHEBI:155926"/>
            <dbReference type="EC" id="2.4.1.370"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:64597"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.370" evidence="8"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWH8"/>
    <dbReference type="GeneID" id="18245378"/>
    <dbReference type="KEGG" id="cten:18245378"/>
    <dbReference type="eggNOG" id="ENOG502QS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036369_3_2_1"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103064">
        <property type="term" value="F:inositol phosphorylceramide mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="328" mass="38238" checksum="46B6FAF8D490387A" modified="2011-11-16" version="1">MRKELKYLIGAHVVIVVYLIWYLFDLITLLHDDSFADALLDVELNPADGVITKPLLIPKIIHQTYKDNHIPENWKSGQQACINLHPDYQYILWTDEMARDFIAETYPWFLQTWDKYKYPIQRADAIRYFVLVHFGGVYIDLDDGCERRLDPLMTVSGFVRKTLPTGISNDVMGAVPNHPFFLKVIDSLKNYQKNWLVPYITIMYSTGPLFLSVMWKQYKRWGVPEAGKIRILMPNNYKTNAYSFFAISPGSSWHLDDAKFIKELANHIALAVFGGFCIVLAFLLIEYWIYNLLISSSKIKAKVTKWLHAKKITRKRKDSNLNVYKEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWQ8</accession>
    <name>G3AWQ8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_91766</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWQ8"/>
    <dbReference type="STRING" id="590646.G3AWQ8"/>
    <dbReference type="GeneID" id="18250110"/>
    <dbReference type="KEGG" id="cten:18250110"/>
    <dbReference type="eggNOG" id="KOG0723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_13_4_1"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF29">
        <property type="entry name" value="MITOCHONDRIAL DNAJ HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="80"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="140" mass="15784" checksum="F196DDDF5DA21B60" modified="2011-11-16" version="1">MVLPIIVGVGATIVAFAVKTTASAYRKFNLLTPEMIGLLNNIKVQRPTTFDVSHPHASQHDYIRRRFINEGFGAKMTENEALMVLGIEGDEIIHLNKQIIKDRYRKLMIANHPDRNGSVYLSQKINEAKAILDESPLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWU5</accession>
    <name>G3AWU5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">6-O-methylguanine-DNA methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA repair MTase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_100831</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWU5"/>
    <dbReference type="STRING" id="590646.G3AWU5"/>
    <dbReference type="eggNOG" id="KOG4062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_1"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="128" mass="14249" checksum="EF3299199DBE7047" modified="2011-11-16" version="1">MKLTDESKAFHYAVYAVVNQIPFGCATSYGHIAYLIGRPQNSRLVGASLKHCHEIVRQLNLQSSENDLIDIDRLPWWRVISASGIISPRGNTAGEILQKNLLTQEGIIVEGTKVSLDENGWFPDDVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWW1</accession>
    <name>G3AWW1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101006</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWW1"/>
    <dbReference type="STRING" id="590646.G3AWW1"/>
    <dbReference type="GeneID" id="18245427"/>
    <dbReference type="KEGG" id="cten:18245427"/>
    <dbReference type="eggNOG" id="KOG1180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_2_1"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="83"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="700" mass="77633" checksum="E4FCA6E180D7C28E" modified="2011-11-16" version="1">MVYQLTTAVGPAQPGETAPRRKVTQKDGCVLRPVDSKASTVFEFFQECVKRNGSRNAMGWRDLKEVHSEIKSVKKIIDGQEQTVEKEWLFYENSPYQFITFPDLLDLVTTYGKGLVKLGIEPEQANKLHIFASTSHKWMQTYLACSSQNIPIVTAYDTLGEKGLTHSLVQTDSSAVFTDNLLLGNLINPIKQATSIKYIIHFDPIDENDKRQGGLFYKSASEAKAKILEINPDITFISYEDVLKLGKEVENDPKYAIKTAKPEDLTCIMYTSGSTGDPKGVVLSHENVVSGVGGVSTVAGRNVVQNTDRVVAFLPLAHIFELAFEVTCFWWGATLGYANVKTLTDASCKNCKSDLIEFKPTVMVGVAAVWESVRKGILAKVKELPPLTQKIFWAAFKAKLAFKDYNMPGSGLFDVIFKKVKQATGGCLKLCLNGGSPISRDAQVFISTLICPMLMGYGLTETVANTTIVDPDHFDFEIAGCLLGSVTAKLIDVPEAGYFAKNNQGELLLQGPPVTKEYYKNEKETADAFTPDGWFKTGDICEWTANGNLKVIDRRKNLVKTLNGEYIALEKLESIYRSNTNVLNLCVYADQTKVKPVAMILPNEPHLRSFLKESNIYSDSELKSKALADLCHDKKVSKAVLKSLLATGKSQGLRGIELLQNIVLLDEEWTPQNGFVTSAQKLQRKKILESCKDRVEEAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX22</accession>
    <name>G3AX22_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112400</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX22"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032218">
        <property type="term" value="P:riboflavin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="63"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="470" mass="51251" checksum="917D9AA304B08AEA" modified="2011-11-16" version="1">MENIQLQDLRGLGSSTGHTLEDLPVVNSKDNIIGMQSVRAHTSEHDDSSQEEEPEYPEGGFRAYLVLLGSFLGLTANFGLVNSSGAIQTYLATHQLSESSASTIAWIFSIYLALAFGGTIFVGPYFDTRGSLSPMVGGTLLVFVGLMAAANSTKVWHFILSLSLCVGVGNAMCISPLVGVISHWFHRQIGFAIGLSSMGGSVGGMVIPIMLRSLYQKVGYAWAIRSLAFMCLGLSLISTFLIKERFTKSVSNDDYDSKRHKFVGVSKKLFNLNSLTDSKFIFLVLGVLLGEMGILCATTYYGTYAIAQGVSESESYILFTLYSAAGVLGRLCLSFISDRLGHFNVMLIMILSTSLSMLAVWLPFGSHHAILYVFIILLGFFSASIFSTTPACLRQITPVRDFGSKYGLMYFLVSCGNLVGIPLGSAIISDSSKFHYNMFALFCGLVSFASSFFWIFSRYKSVGFRLNVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX30</accession>
    <name>G3AX30_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_112417</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX30"/>
    <dbReference type="STRING" id="590646.G3AX30"/>
    <dbReference type="eggNOG" id="ENOG502S32U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436768_0_0_1"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="180"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="520" mass="57919" checksum="2B51424B1AA438D3" modified="2011-11-16" version="1">MSESLLKSKQFRSRKNLKSLSISSPILEASNSAAVPKTLLSPTSYFSNSLSLSTLSLSDDRSNTLPTGRAHSVDALVSSPVSVDASFGTIILSAKYDFCAENAEELSIRRNDYLKLIDRPGDGWLRVRNVSNKRIGLIPASYVKIAVNDLISPITHAWLTDVSAVDADSTADSRDLFDFEKHPSIKHVNVSQVLSSQDRFWYRVDLKMSDNSNIYLLKCYQDFYNLHYSLSVLHHDNLPAFPQPFNSVHHSVKDKKYMERLLVRCNELNVYMNKLVKLGYYSDSDELTEFLSVHPRVVNPENTDSRSINHQLCAGAVSVFDSFQSHHDASRKSSSSAVPASVVESPSLSSFSSLIDSYENSSFSSTAASTGTQQQNYKYSSGCKVDTESIFSKSPVTPVNDGGRFDEVTTPITPVTPNTPDFAASNFDTFKPQSEYVKVKVLFNNEDNDIIVLKVPRDSLTSLGDLKKIISYKIYKDEDLTNHYRLTVKDQAPVADTQLLQLVRASTKVTLNLVRIRGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXS1</accession>
    <name>G3AXS1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112549</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684254.1">
        <property type="nucleotide sequence ID" value="XM_006684191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXS1"/>
    <dbReference type="STRING" id="590646.G3AXS1"/>
    <dbReference type="GeneID" id="18246575"/>
    <dbReference type="KEGG" id="cten:18246575"/>
    <dbReference type="eggNOG" id="KOG3381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075876_1_1_1"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000004">
        <property type="entry name" value="cytosolic iron-sulfur assembly component 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="202" mass="22333" checksum="0D48BF2B4644253B" modified="2011-11-16" version="1">MSDEVINANPTIINVESLPTRLGAYESAQTAVKSKLLDTFTSLSLFQTENLSSPELTGESSDNWSDDDEPEEEIDAQEIFDLIGSISDPEHPLTLAQLAVVNFADIHVKNGPDKHKDLSEVLIKITPTITHCSLATLIGLGIRVRLERCLPPRFRIRILVKEGTHESENQVNKQLNDKERVAAACENEQLLTVISQMLGSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXX8</accession>
    <name>G3AXX8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112583</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXX8"/>
    <dbReference type="STRING" id="590646.G3AXX8"/>
    <dbReference type="eggNOG" id="KOG3348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_4_0_1"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="86" mass="9449" checksum="8C62622461D274E3" modified="2011-11-16" version="1">MSLTTESFQLIIKERLEASLVQVEDMSGGCGQAFAVIIVSPLFQGKNKLMRHRLVNNALKEEIAGIHAFTQKGFTPEEWTAQGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY52</accession>
    <name>G3AY52_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112636</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY52"/>
    <dbReference type="STRING" id="590646.G3AY52"/>
    <dbReference type="GeneID" id="18246614"/>
    <dbReference type="KEGG" id="cten:18246614"/>
    <dbReference type="eggNOG" id="KOG4032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074896_0_1_1"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23393" checksum="F9FB2609B2286D74" modified="2011-11-16" version="1">MSRIDPTEFVQALDGQSSLKFPNERQQSHFELGVTMAVHKWEELNVAVDNSWGGPNSADKRDWISGIVIDLFEEKIVDVQLVEETLLYAMLDEFDVHVDNDSALEIANMIIKFYQKAQLNDFSDIDILYERWQIRQQNRQAQKVKVEDDPENPSSDEEDDEEHEHYHEDQHIDDSMEVDNGPVVDDDGFTLVQTKKGNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYP1</accession>
    <name>G3AYP1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="10">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_112774</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYP1"/>
    <dbReference type="STRING" id="590646.G3AYP1"/>
    <dbReference type="GeneID" id="18246666"/>
    <dbReference type="KEGG" id="cten:18246666"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="11">
        <location>
            <begin position="18"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="469" mass="51848" checksum="2E9C7CD64F48DB2C" modified="2011-11-16" version="1">MVYALSEKHRQLTESSLASYDPEVDAIIKDEIERQKHSIVLIASENFTTKSVFDALGTPMCNKYSEGYPGARYYGGNEHIDRMEILCQERALKAFNLTSDKWGVNVQTLSGSPANLQVYQALMKPHERLMGLDLPHGGHLSHGYQTDARKISAVSTYFETMPYRVDLETGIIDYDMLEKTALLYRPKILVAGTSAYCRLIDYKKMREIADKVGAYLVVDMAHISGLIAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRRGVRSVNPKTGEEILYDLENPINFSVFPGHQGGPHNHTISALATALKQAAAPEFKEYQLQVLKNAKILEQEFLSRGYNLVSNGTDSHMVLVSLKDKKMDGARVETICENINIALNKNSIPGDKSALVPGGIRIGAPAMTTRGLGEEDFKKIVSYIDQAVIIAKEIQDSLPKSANRLRDFKAAVVQGSEQISSLKQEISAWAGEFPLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYP9</accession>
    <name>G3AYP9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_102320</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYP9"/>
    <dbReference type="STRING" id="590646.G3AYP9"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_4_1"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="96"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="189"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="276" mass="31564" checksum="2ADD2E266F4296DB" modified="2011-11-16" version="1">MNTLQIDSISGLVAGLSTTLITHPLDLIKVRLQLSTSNQPLRHILQNISKNSQSSKHYILSELYKGLSPNIIGNITGWSLYFTLYEQFKTSFSQSPNTIKYFSASTVSGLVTSLLTNPVWVIKTRLLSEKSRYSSMADAIRKIYTEEGVKTFWKGSVPSLFSVFQNSLQFTVYDHLKNSKLLDNLKNDHEIQYYFTASSISKFTAMLVMYPFQVVRSNLQKFDSTNIYNELRYLYGTNGFYKGFTVSLLKVLPATSITLITYESMRNWLTRINEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYQ4</accession>
    <name>G3AYQ4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_102052</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYQ4"/>
    <dbReference type="STRING" id="590646.G3AYQ4"/>
    <dbReference type="eggNOG" id="KOG3282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_0_1_1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="191" mass="20780" checksum="5F88B0BA7E9FEC76" modified="2011-11-16" version="1">MSRTVGFISVVAVSFITGLFSSWLLAKRGCYSTNRSKCSFTILDETEEETEEEDEGVDVDSSELNQISGEVRMTLVVRQDLKMGKGKGAAQCSHATLALYKKMSNPQSPAYNPEMLTRWEYGNGQAKITLQVPDQEGMDTLFAQAISLGVNCYIVHDAGRTQVESGSATVLGLGPAPKVVLDQITGDLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYQ9</accession>
    <name>G3AYQ9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_96983</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYQ9"/>
    <dbReference type="GeneID" id="18250645"/>
    <dbReference type="KEGG" id="cten:18250645"/>
    <dbReference type="eggNOG" id="ENOG502RPSC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370523_0_0_1"/>
    <dbReference type="OrthoDB" id="4075894at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="689" mass="80243" checksum="D682E05D0273F360" modified="2011-11-16" version="1">MTKEDILGLSVSEYRELIRLPVQRIEDAHGFCTKVAQIVEQNLLRDHRLIAYLINSIPNDTIKMAVLVSLRRLYSNNFPKLSVIEMLEDVKSERFRQLFLYIMEMIVNTEDQSPIDLLCTYLNHMSLLNVVNTHPIVVPTELFKKVMTMTPTPRKAEMYSYMVNINFIPEDLSILRQLQYQLSKGSEIEKYIVRTGQLNAKWHDTVKPITNETLKQKMLYFFSFDNIRMFTFQAIKRKDLADSNMYLDILVSKFEQNCTEIENSVFVLDNAEEMISSRVQNIMRTVLFYLMTFKGADASIKIIHYMLKNNIEIKFEILSTIMSNLMEQGFYDEAIVVINSIKLDALNGREKKVLVDNIFKLMAGKFSDSPKVLLGYATTLFRSPDQDISITDLLNGFRILSVAFGSTKLEYVKSPNIVSASVDQNLTGVRFSHESLYHIYTTSLQNTPREEITPEFIFRLFMIYLGKIKTSKHVFLNERKISDSIVTLFLNYSMKVDPTSNKMKLIRDKNNYDTARAVLLGFFKSFKLNPSLIKPYPFELMIYSSLILHNDLSSASEFIRVSRSYKLPFTFNQLYPFIIYHYQNGQFKQAESWYKMLVSHGIKSKSSEMNRIFEIARELKWDIKGFSYRRQVNLKNRASREAMKDINDDNFSSLGARLNEDLAAFENQEKMFPNFKENLTALLQTSQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ37</accession>
    <name>G3AZ37_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_119040</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ37"/>
    <dbReference type="STRING" id="590646.G3AZ37"/>
    <dbReference type="eggNOG" id="ENOG502QPY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011075_0_0_1"/>
    <dbReference type="OrthoDB" id="3886144at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="914" mass="101934" checksum="1F76A3E30A8F0700" modified="2011-11-16" version="1">MSKVNRPNTTVEPSEPDLSPNSSITPTDSNNTPRSITTGPSSTSIPPATKRKNTKSRNGCLTCKKKRLKCDETKPSCLKCLKKNIACGGYATRFKWRSFNDESTAHPHTSPSTLRRHLELASISVTGKSIKDIKRENDLIEEGINPATYNKRRRQPETTSKSNAKLSFSSNSSINPNMISEFRRQYTKTGSVGLNSLAEAAIDEINTRSSDIYRPHPGSIPTMSPTISDFLTPAARSPEVITNKSLKPHLNQHHHTQLTMSNPSFQNIHLSPTLSALINSAFGHDEDLRHNSLFDEEINPGGSINGISTPLTVSVKSTPIYNVGSNSSMLLTAEQEQILGLYSQYTAEILSIKNGPNENPWRKLILPYALQYSCLFNSIASITLFHMAGNEGIATNRNNLRTRGYMYMKRCILELASGLSASTDGTGEPNQQLPADIAIAICLNLAVSETWDKHTSSGIAHLKGAKTMIQNVLALLKENQNEMCKKRRKIHSNGSTPKDTEEYGVLVNSKRDELKKRLVLVEDSEWDKILTGEDEVEEDHEEAKPDLLKIPKSTQFLFNIWIYFEVLAQMTTESDEKGIDLVASITTILQDSKKKEGKGSKFLEDKLDRSPDVKSESSESTLGNVDTFGGIHRGFNNLFDNFENISLNSDYVDPLLGCAQSLFSIMGKVASLISNIRKIRKKDKKLPDRNTLTTITRATQLRQDLLSWKPTISASMLEQMNAANNADNTKTDLSSCIATAEAYRFATLLYLHQAVPEIPSLSSHQLAEKIFILLASIPTTSPTYTVHIFPLLVSSCEAELAEEREWCEERWRILSSRLWIGNVDRAFEVVKEVWKRKDDYIRKKQINSLSIDDVFIPHGTGNDNEKFKNISTQLSGLMAAINESCPVDDITGGIYSKLHWSTIMKEWGWEVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ43</accession>
    <name>G3AZ43_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD-box helicase OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112873</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ43"/>
    <dbReference type="STRING" id="590646.G3AZ43"/>
    <dbReference type="eggNOG" id="KOG0926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1540788_0_0_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box helicase OB fold" evidence="1">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="202" mass="21658" checksum="104C5C256575F3E0" modified="2011-11-16" version="1" fragment="single">MNTKSESVATTLEAEGITKLGVPSEKQVASIKQIVASGFLDQISVRADIVNSEVSVPKSTSIINIPYQTITLTAQSDETTDGFVYIHPHSVLAASGEMPPDMMVYQLLNLSSNRKEGVVTKARMKALVDISGKQLANIAKGSPLLTYSKPLGNKYAPKNITSSKREAYVIPRFGAAIGSGGLGWDLPVIKVVQVKNNGQWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ61</accession>
    <name>G3AZ61_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112878</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ61"/>
    <dbReference type="HOGENOM" id="CLU_2891931_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="63" mass="7117" checksum="9367FF791FD3B2CD" modified="2011-11-16" version="1" fragment="single">MENCFNTTRPVLSHGDSSNRIYQFSPEHVEIQELDSRLLKRSKSVKSLDHPVSFIPSISSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ82</accession>
    <name>G3AZ82_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_101629</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ82"/>
    <dbReference type="STRING" id="590646.G3AZ82"/>
    <dbReference type="GeneID" id="18245488"/>
    <dbReference type="KEGG" id="cten:18245488"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="222" mass="24263" checksum="472D9CFD66A0E274" modified="2011-11-16" version="1">MKLITVLISGSGSNLQALIDAQASNSLGNGNITHVISSSASAYGLQRAQAAQIPTTIHQLKTYYKGIPKENTQERTQKRHQFNVDLANLLIYGNIEGNPDAQYTKPHLIVCAGWMLILSPQVLEPLEKAGITIINLHPALPGAFDGTHAIERAWKAGQAGEIAEAGVMIHKVITEVDRGQPVLVKRLEVGKPQETLEEYEKRVHDLEHIAIVEGTNMVLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ86</accession>
    <name>G3AZ86_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_101270</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ86"/>
    <dbReference type="STRING" id="590646.G3AZ86"/>
    <dbReference type="GeneID" id="18245451"/>
    <dbReference type="KEGG" id="cten:18245451"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_2_1"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="18">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="19">
        <location>
            <begin position="114"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="17">
        <location>
            <begin position="248"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV66032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="715" mass="80623" checksum="5B34417D666D5195" modified="2011-11-16" version="1">MERLQQVASQVTSAVSAPAAPAHPLDPLSPQEIKYVTSIVKEKYSGKTLNFNTVTLREPPKNLYYNWKEKKGPLPPRLAYFVVIEQDVTAVQEGVVDIPTGQIIQLKQTEGVQPILTTKDLSDTEEIVRNDPNVIAQVVLSGLDKSEMKNIYCDSWTIGYDERWGASRRLQQALIYWRSHEDDSHYSHPLDFCPIVDMNAGKVIFIDIPTKRRKVSKHKHTGFHPRDVASKFGTKENPSGYRQDDTPINITQPNGVSFNMQGNVMEWSNFKFHIGFNYREGIVLSDVNYNDHGNTRSLFHRISLSEMIVPYGCPDFPHQRKHALDIGEYGAGYCTNPLSLGCDCKGVIHYLDAHFVDKFGDPSTIRNAVCIHEEDDGILFKHSDFRDDFQTTINTRGKKLIISQIFTAANYEYCLYWTLRQDGTIKLEVRLTGILNTYICDEDEDIGPWGTIVYPKVNAHNHQHLFSLRIHPRIDGEGNSAATSDACPSPYPTGSPENVYGNGFYAKKTVFKTVKDSLTQAESKYARTWDMFNPKSINKYSGKPASYKLVSTFCPPVLAQPGSLVRKRAPWAEHTTQVVPYKDEDFGYGTLYPSGDHVAQWSGDGLRGMRKWIGDGTDNVENTDIVFFHTFGITHFPSPEDFPVMPTEIFDLMLRPRHIFTENPVLDIKPSYSKMTSEVRTGAKGLDSCSLNVDSTSRLAFNKTSSSSDSCCSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZA4</accession>
    <name>G3AZA4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent rRNA helicase RRP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_129471</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573</strain>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZA4"/>
    <dbReference type="STRING" id="590646.G3AZA4"/>
    <dbReference type="GeneID" id="18249384"/>
    <dbReference type="KEGG" id="cten:18249384"/>
    <dbReference type="eggNOG" id="KOG0330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="104"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="302"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV66047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV66048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="485" mass="53444" checksum="9C3C3423FB527D83" modified="2011-11-16" version="1">MAHKMKDATKKASKSARPSSGILDTQALADKIRKNALKKKQEQAAAPALEPPIAPSVVLEDKVVDASAETAIQSFAEFDLIPEILESIQAMKFTKPTPIQAESIPHALAGKDIIGLAQTGSGKTAAFAIPILQALWHAKTPYFSLVLAPTRELAFQIKETFDALGSSMGLRSVCIVGGMDMMDQARDLMRKPHVIVATPGRITDHLEHTKGFSLKNLKYLVMDEADRLLDMDFGPALDKILKVIPVERTSYLFSATMTNKIAKLQRASLKNPVRVAVSNKYQTADNLVQSMMLVSDGYKNTFLVHLLNEFMGKSIIVFTRTVANSERTAILTRLLGFSSVPLNGQLSQTQRLGALNKFKSGKANILIATDVAARGLDIPSVDVVINYDIPTDSKAYIHRVGRTARAGKSGKSISLVTQYDLELYLRIESVLGKKLPKDPSPSKQVLNTLHVHVDRAVAEAIRQMKDIHERRGNRNHRDNHDREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZE4</accession>
    <name>G3AZE4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_101326</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZE4"/>
    <dbReference type="STRING" id="590646.G3AZE4"/>
    <dbReference type="GeneID" id="18245458"/>
    <dbReference type="KEGG" id="cten:18245458"/>
    <dbReference type="eggNOG" id="KOG4756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1778531_0_0_1"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="165" mass="18722" checksum="534D861F98C7DF9F" modified="2011-11-16" version="1">MRASSVLNLQASATANLRRPWQTFRDGQIWYGLTKSGSKRQALTTKQGNKNYYKGTRSSGIGKLNNAGNYMVDWTKVRTYVVPADISSVSFKPLVSPNSPQLEQRYVGYADGPKDGELAWKNVVDFIEYGENYDVQDIEENEYKEEYVNPKIVQSQIELPEGIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B089</accession>
    <name>G3B089_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_133644</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B089"/>
    <dbReference type="HOGENOM" id="CLU_343543_0_0_1"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="824" mass="94614" checksum="10EA32FC452E93B4" modified="2011-11-16" version="1">MTTKKRSRLVLVCDGCHGRKIKCDRQVPCNSCKARGIGELCRYSAIQTELAKQGKVVTTDPTVSEVAKLSNRIEELEAMVSVLASPGSSSHSPSVKSLSYGEPPSPSVDDDYTIPNFFFPSTDDSIMRKSAMYMGNHLSFFMVLAKDNAHNAFWYTNGEKFHKKKIALCKLEGVGQLLDKDPEHYKTVEKKCSVYFGDSYIPNNAKPSFEVKKAINAYQSQFGRVMFFDNYISDCSLYLKASYILPSREIIFRYMEVWFQRLGPYFPIVEQVGFSKAVGRIILERDNNSPGVRLNIEVKSDLAVLSCLLYLLRLTYLYMVSIGQKSTNMDLAAFPIYVDVISIARECLKEIPLSQVPIIEVLEAHTFAKVHKEFSHDEGDGVREGDTYVRILIPYAIACGLHRDPGVETPWMDQNRRRKLWFFLVSLELYEVAVFGREMTSLTCSNVNLEKVNIPGDDGFYHAFSRSLSLRAILQKLTALASDLTKGTGVDQFANLTSQFESVIESSYGPFVSRVLRQVEIQNDPKSVLELYHLFSFKICCLRLNYALYLVYEKKGDVQLSYKYYSRVMEIFFGEFFPSLAIIFENKDHIDPMLFMFTRTIFTRLFIVFLLFSVTAIIHMNHTIRYQVDKEGVEPPKFYYDITSNIRRLWSYACSFCGFYANRFFTYWTIVKMLMLSMETVDMYLTFPSQCEGYSARWMFTVPQMQHLAETIENATVSCKPKSWPAQKGANFEWLQLIPYDDRKSLQENLETQRLHINQIDATWNVFGNAIQDPIPDTFKNTDAYSDSQVSSLMDPDMNSLDFFGVGFPSSLKEFVMSEDYFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0M1</accession>
    <name>G3B0M1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_113186</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0M1"/>
    <dbReference type="STRING" id="590646.G3B0M1"/>
    <dbReference type="GeneID" id="18246845"/>
    <dbReference type="KEGG" id="cten:18246845"/>
    <dbReference type="eggNOG" id="ENOG502R89W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085450_0_0_1"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV65426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="206" mass="22933" checksum="DEA29DF68236EA16" modified="2011-11-16" version="1" fragment="single">MPSLSYFLDSIDSSCQRIEELQFRPPGMFTNAIVTKPDITQLLKDANPSESLLYRVTNPVDGSIIDRPAKLLVRVDGKSYFEDDNGEEYSNHDVSSNKIRRVAVNVPRLVANSAQTTSGASSDMSSSPVKASAQITEAASIYRSLIEYTNKLPVANEEFILSIRAMKEEYEQFSGQLQGLQQEYDEQQKLLQSHNVFGLDGVSEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1M1</accession>
    <name>G3B1M1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113248</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1M1"/>
    <dbReference type="HOGENOM" id="CLU_1165718_0_0_1"/>
    <dbReference type="OrthoDB" id="4092372at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="216" mass="23056" checksum="B618B103A5DBF3B6" modified="2011-11-16" version="1">MARTVYPKRPIRCDPFVDQMDTIDKALIEVQNQPMSIYAINKRKYGNVSRQRAAQYPSSYSTSLGYSTPSGPHQPSEAQRQLSSHHQNVPQISSQISSHQPQISSMGSQPSQLQATAQMSQTFGLSSLGSGFGYSGHGNEFSYNGGHSTAAAAPAQTTTGLGSSFDPFSSIDLSDTRFNSGSGSTLNASSFKNLTSNIWGNSGSEPSISTDTSVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B238</accession>
    <name>G3B238_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_104082</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B238"/>
    <dbReference type="STRING" id="590646.G3B238"/>
    <dbReference type="GeneID" id="18245685"/>
    <dbReference type="KEGG" id="cten:18245685"/>
    <dbReference type="eggNOG" id="KOG1637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_1"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="305"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="726" mass="83597" checksum="2181A541CD708EC1" modified="2011-11-16" version="1">MSSELENKVEALSVEGDKPQVPASKPVKSADAKAPKRDPLLLHPQPDFIDSRIKMFDELKAQYDEKISTKERKDIKITLKDGSIRIGKAYETSPIDIANDIGKSFSERQVIAKINGQLWDLSRPLEDDVALEFLDFDHPEGKQVFWHSSAHVLGEACECHLGSHLSYGPPTSDGFFYDMSINNGEGVVSQADFANLEKVATKGIKEKQKFVRLEMTKEQLLEMFAYNKYKVQFIQEKVPDGTSTTVYRCGPLIDLCLGPHIPHTGRIKAFKVLKSSSSYFLGDSANDSLQRVYGVSFPDKKLMTEHLQFLKEASERDHRKIGKEQELFLFHEMSPGSAFWLPHGARIYNGLCEMLRSEYRQRGFEEVITPNMYNSKLWETSGHWGNYKENMFTFDVEKDTFGLKPMNCPGHCLMFKSRERSYRELPWRVADFGVIHRNEFSGALSGLTRVRRFQQDDAHIFCTEDQIEQEIKGCFEFLNRVYGIFGFEFEMKLSTRPDKYVGELETWNKAEAKLENQLNEFLGKGKWEVNPGDGAFYGPKIDIMISDALNRSFQCATIQLDFQLPQRFELEFKSETNDKQNSVSRPVMIHRAILGSIERMTAILIEHFKGKWPFWISPRQVLVVPVGVKYNEYAESLKEQLVKKYGFYADVDVTGNTLQKKVRTGQLYKYNFIFIVGEQEQQENSVNVRNRDIQEDQGKNETVAFETVVKQLADLRDEKRRDNKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B241</accession>
    <name>G3B241_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_103580</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B241"/>
    <dbReference type="STRING" id="590646.G3B241"/>
    <dbReference type="GeneID" id="18245639"/>
    <dbReference type="KEGG" id="cten:18245639"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_0_1"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="132" mass="14536" checksum="ACA4EF738E4D2325" modified="2011-11-16" version="1">MIYLKSLLNVIDNSGAQVVECIKVLRHGPRNFAKVGDEITVVVKQARPLTAEITGSSANNRVKRRDICRAVVVRTKAPFRRPDGSTIRFDDNACVLVNKNGDPLGTRVSSVVAQELRNSKYTKIATLAPKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B290</accession>
    <name>G3B290_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Genetic interactor of prohibitin 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113400</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GEP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B290"/>
    <dbReference type="GeneID" id="18246941"/>
    <dbReference type="KEGG" id="cten:18246941"/>
    <dbReference type="eggNOG" id="ENOG502T4P5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794582_0_0_1"/>
    <dbReference type="OrthoDB" id="4018833at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031455">
        <property type="entry name" value="Gep5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17053">
        <property type="entry name" value="GEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="321" mass="38645" checksum="1B5CF7ABC1D12364" modified="2011-11-16" version="1">MSVTPYYKQVLQRIRRLPFDSYTQQCLQKHARQQFSTPLKYSYSHSGKPVDAKKYNRFIKICDEILIYEDWNKLTMLFDYIFKDVMGSESYPEQYGALKKFESYNYDQVRDIYPQVHLFKRLDVPEKYHQEFDKELKQEKDDFSLVNYFKFDANTIPDIPLISRNQLNDEHEKEEMKKVLNHVKQMYNFIASKENITHLKLRPMEVTYPSNKYGLPLHIIQRDKLLKDKLIYVKSVVNRYKPIPASILDQLGQITNGDINPHFFTYMIQKRRKVIVKIKGNKKFIPDSKNIVKIYREYLSKQFYYDPNTGKYETSSVMFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B296</accession>
    <name>G3B296_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_120380</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685430.1">
        <property type="nucleotide sequence ID" value="XM_006685367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B296"/>
    <dbReference type="STRING" id="590646.G3B296"/>
    <dbReference type="GeneID" id="18248772"/>
    <dbReference type="KEGG" id="cten:18248772"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030658_0_0_1"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="55821" checksum="FF1774779DC09D0E" modified="2011-11-16" version="1">MEKNNPLLPFAFTRSTSGISNEVHLDTTPRPRAVIDENASSMYHTRTPDTKKSFARPTLTTAPGLKRRVGESFNEKDDIKRRVTAFEGLDSDEPTMIDTTSTDFSQDELFQRSFLDGESAGKSHYETIPPSSPPIDTYLSSEYDPYAKFSMPLSPSQRINSDAHYGSSPSKPSVVRLDSETDFGIDKFNRFRPPENQCPSTDRDFSMTAEAKEERKKMIYSKARDIVIAAFEDMKTSIDLESMGLNEVPSEIKDLNDLVVIGQDSTQIIFQLYLTNNDIRVLGPPLFKFTKLNVLALRQNKIERIPALIKNMVRLTDLSIGANRIKFLPWQILNLPVLQSFRAGPNPFLKVPNDAIEIKSMTLNPIKNKRFVSRIEYFKDDEKLIPSLKSLCLSKIAQYDVSYQEARQWRKNTPRLYHESIKKAIAQGNFEETCAECDRLITDPVAEVIEWWDFLQNNQIPFKKEFCSGMCVKRYSRRVIEDSDSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2C0</accession>
    <name>G3B2C0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="8">1.13.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">4-hydroxyphenylpyruvic acid oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CANTEDRAFT_120410</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>3-(4-hydroxyphenyl)pyruvate + O2 = homogentisate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16189"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="EC" id="1.13.11.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16190"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="8"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685445.1">
        <property type="nucleotide sequence ID" value="XM_006685382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2C0"/>
    <dbReference type="STRING" id="590646.G3B2C0"/>
    <dbReference type="GeneID" id="18248776"/>
    <dbReference type="KEGG" id="cten:18248776"/>
    <dbReference type="eggNOG" id="KOG0638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_3_1_1"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000022">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 25" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0408">Iron</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="25" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="24">
        <location>
            <begin position="300"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00029786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGV64639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="517" mass="58747" checksum="13D3DD176657A938" modified="2011-11-16" version="1">MLEQLPFFPADNRYDPLFDSSVNELLLDGYTNQKTAQDGFLGFHHLKYTTSNAKQIARLFSMSMGFQEIAYRGLETGSRVVSSHVVKNGQIIIEFISPLKACDENPSMLPATYETWSQTTAQILEDKLISINNQMFAMVEKVIGNSLEESLVINEDKKQQILNQIRSTSQYGGMMKLFERLTADVSQYSTLTIHDLMDSFLISNYLTYHGEGVMDMSFEVVDVDRIFDKAVKAGAVVIKTPKVFFDQYGSMKLATVGIPDTDIHHTLVENINYQGSYLPGYIDPVEECADTGNTPVMLYTIDHCVENYSWNQMITQAKLYAKMFGFHKFWSVDDTEIATENSSLNSFVVASSNGKIKMPINEPSEGKMKGQIEEFNDFNGGPGIQHIAMRTFNIIDTVSSMKANGVKFNEISSKYYETLSRRLQHDDIRLIEDFETLRKLNILVDYDVTTRNPKTKVCAYLLQIFTKPLGDRPTIFLEIIQRHHHQGFGKGTFKALYQSIELEQFKRGNLVPSTRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2C9</accession>
    <name>G3B2C9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SYM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113429</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2C9"/>
    <dbReference type="STRING" id="590646.G3B2C9"/>
    <dbReference type="GeneID" id="18246953"/>
    <dbReference type="KEGG" id="cten:18246953"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_8_1_1"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="201" mass="23271" checksum="01BFA008EFD7C9E6" modified="2011-11-16" version="1">MSYYTKYNQLLLKRPLVTNMVTTGILFGSGDFLAQRLFSQNNKKYDYPRTLRAIAYGGILFAPLGDKWYKLLNRLTVPKSLSWSDKTHNRVNTLLRVGVDQLGFAPLIAIPMYYSAMTVLERSPDPVNDISAKLREHWLPTLKTNWLVWPAFQTLNFYLVPVQLRLLSVNLISIVWNCYLSYVLNDQKSHLLHVSEEEVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2I1</accession>
    <name>G3B2I1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_113473</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2I1"/>
    <dbReference type="STRING" id="590646.G3B2I1"/>
    <dbReference type="eggNOG" id="KOG2923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155991_3_1_1"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="69" mass="7856" checksum="B5724071D4C248FC" modified="2011-11-16" version="1">MDVYDEIEIEDFTFDPATQLFHHPCPCGDKFAIALDDLLDGEDIAVCPSCSLMVRVIFEPEDLDEYVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B330</accession>
    <name>G3B330_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_105103</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686381.1">
        <property type="nucleotide sequence ID" value="XM_006686318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B330"/>
    <dbReference type="STRING" id="590646.G3B330"/>
    <dbReference type="GeneID" id="18245781"/>
    <dbReference type="KEGG" id="cten:18245781"/>
    <dbReference type="eggNOG" id="ENOG502QPR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059407_0_0_1"/>
    <dbReference type="OrthoDB" id="4075408at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="184"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="391" mass="44909" checksum="8DCCC02501DFF9F2" modified="2011-11-16" version="1">MTAGDPNNYVLEQINHDGELVDFTRLQNSQAWKGILTSEEYTFRERLLGNCDMTQDLRVYVLKDINNPSEALCSIELLIRDALVYDKVDGKVVHRKVRSGCIGGVFTYKQHRRRGYARIMVNKLVDLCQAELLEDGFLFLYSEVDEFYAESGFVSMEVPVVVIPVDHETPTRFTGHQGVEVPEGSLVPLGFAEFEDVMNVYRKHSLQDIEARTRTDGKTHLTIVPDHRSFDWYHVRAKYVHGKVHDLKLKIDLGKMDQVFSLFKTVGPEIFGFKLENKGELLGFIVWTFDWTPEKFVVKVLLIHVCDGHHQSLRLKLLGYLKEYIQFYGEGFTKMEVWGSELQPTGVDLNSVGTVIPNASRSAMQMMVAKDQDHLKKGEVVWDNNNKLPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B333</accession>
    <name>G3B333_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114099</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B333"/>
    <dbReference type="STRING" id="590646.G3B333"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066267_0_0_1"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="110"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="182" mass="20392" checksum="BA067267BACAFAE9" modified="2011-11-16" version="1">MDNKISLPPIRDLLNTSMSTPFTLPPSLPSVSFNRPYFPPYQAGPLSSYQAGSLSSYHTTPPVPAPVTAPDTNYHYQSSAVDQPRSTSSSVSEGSSSVGNSNSTSPKATVEKRKTRNNLPKETTYVLLKWLNEHLNHPYPNSFEKNHLMMTTGLNQQQLSNWFINARRRKIKVLKEQQRMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B334</accession>
    <name>G3B334_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex subunit Exo70 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_122135</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B334"/>
    <dbReference type="STRING" id="590646.G3B334"/>
    <dbReference type="GeneID" id="18248882"/>
    <dbReference type="KEGG" id="cten:18248882"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010236_4_1_1"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="4">
        <location>
            <begin position="207"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="582" mass="68030" checksum="EE1EF815E4D7E74D" modified="2011-11-16" version="1">MVDIDEADVAVLNQNLVKSKELFNSISKSLNRISNKSTNASNKIKPVLRDVNKLTSERKDIEKGIDKLKEVSNYAERTSLYETILNNSIEIIGLKKYIDTLNKSKSLLKEMKTQIKKFHGILINFENLIDKSEFKLTTFFKKQVEAGKFNDILIISNYFNHDNKQINKTLISSRSTKLMSKMKQVEASNSFQPKNLGPKAPPYEKKTNGIHAYTYELLNLLEKEYELLERLDRVDLFGLIVDHQMDSLNEVMQKNYVAYFNNENLVTNDILVLELTQMMHEFQVSFERFDELKKYAVNMIFDKLLNVFTQLIKEYFKFTETRIHAVEKLTELNSTELVVELITRVRKLSDHSVGLHLLISHYSIGEWLNIKGLRFIGVYTSVIKNDMEEPQLVSNFMSDMIDCIMVNIETRLKEFKKSTQGFYLIKNTMLIEGIISRSSNLYELLGAIGMERLNKLKSRFLKLFLDDWNYASYIIIRDMTQLTTLSATNQSSELSSKEKDQIKKLFETFNESFEEAVRNYEKFSISDPNLRNYLAGEIKKLIMNAYFKLYDKYGNSSFTKNKAKYIKYNKMQFESILNDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B369</accession>
    <name>G3B369_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_93604</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B369"/>
    <dbReference type="STRING" id="590646.G3B369"/>
    <dbReference type="GeneID" id="18250304"/>
    <dbReference type="KEGG" id="cten:18250304"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079690_4_0_1"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="149" mass="17133" checksum="228B68080180C5B6" modified="2011-11-16" version="1">MDQMPVHSPSASHDMPMPDMPARCSMNMLFTWDYTNTCVIFHWWHIRSVYSFLFSFVAVAALATGYEFVRHTISLWEARTLAVASDSRAMSLYRLKKSVFYGFQIGYSFMLMLVFMTYNGWLMLAVVLGAIGGHWLWGHKSTGRGLECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3D3</accession>
    <name>G3B3D3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114166</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3D3"/>
    <dbReference type="STRING" id="590646.G3B3D3"/>
    <dbReference type="GeneID" id="18247298"/>
    <dbReference type="KEGG" id="cten:18247298"/>
    <dbReference type="eggNOG" id="KOG4821">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039013_3_0_1"/>
    <dbReference type="OrthoDB" id="188035at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000024">
        <property type="entry name" value="YMR034C-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640:SF5">
        <property type="entry name" value="SODIUM_BILE ACID COTRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 10 MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="440" mass="48744" checksum="80F8748317731173" modified="2011-11-16" version="1">MSSPNPTDTVKPPPKKWVKTLKVVINYIISQWFFVFLGIFIMLAYFFPNFAKSHGTLKAEYVISYGAVAVIFLVSGLSMSTKDLVKNMLNWRAHFTVLSMSFLITSAIIFGIATGIKHAHDGAIDPYLLVGLIVTHTCPTTVSSNVVMTKAAHGNDILTLCEVFIGNILGAFITPALVQLYLQGEWAFGNPSKQSGGPDLSVSQLYAQVMKQLGLSVFVPLFVGQVIQNIFPKQTKWTLTTFKLNKVGSFMLILIMWQSFSTAFAQNAFESVSHASIIFLCFFNVGIYLFFTAMSYVYSRPFPVKYFLSKEPDASSTATYKWCYKIFKPFFYSRKDTVAVMLCGPAKTAALGVSLVTSQYGSDNSHLGILLVPLVLYQAEQVFTAGILVNFMRKWVHAEDPKPDVETMVEQEPASSVVKDAEDPSVEHQSTTNSVTTLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3D5</accession>
    <name>G3B3D5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-threo-aldose 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114168</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686456.1">
        <property type="nucleotide sequence ID" value="XM_006686393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3D5"/>
    <dbReference type="STRING" id="590646.G3B3D5"/>
    <dbReference type="GeneID" id="18247299"/>
    <dbReference type="KEGG" id="cten:18247299"/>
    <dbReference type="eggNOG" id="KOG1576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_7_2_1"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="356" mass="39667" checksum="192FA472C4D8EFEE" modified="2011-11-16" version="1">MLITEKPVGPTSPPRPYSITDLPPLIVGGATFNYQYTDNPEAAPIYEILDTAFNSGLIAVDTSPYYGPSEILVGKALTELSTKWPRETYFICTKAGRIALNEFDYSASAIRKSVKRSLERLNTEYLDLVYLHDIEFGEIDDIMDGLKELKRLKAEGIVKNIGITGYPVDFLYRVALAAHNNEEIGSLDAILSYCHGCIQNTTLFEYYSKFFDECHVKKIMNGSILSMSLLRSGKTHTFHPGSTELKEAVAAVAKDLSEQGVELAELSTRFALKSWLFDTSKATQSDKTNLSWNKKTSVVLGLGNVDELMSAITNFWKVKLNVSNSSEDDAKYVAQVQQQLGSHFNESWESGIEHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3E8</accession>
    <name>G3B3E8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LMBR1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_122366</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686463.1">
        <property type="nucleotide sequence ID" value="XM_006686400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3E8"/>
    <dbReference type="GeneID" id="18248899"/>
    <dbReference type="KEGG" id="cten:18248899"/>
    <dbReference type="eggNOG" id="KOG2296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016542_0_0_1"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="608"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="74351" checksum="B0C4A27AAFB8EFB7" modified="2011-11-16" version="1">MWIPTAIGYTFSLLLSVWGIQFYINVLKRPIYFSVPVVLAVFIPISIIFLMPLDYVQHNAKDAVAWLDLPDVVILYLWKVKYWTTFLLTWLVLPLLQEFYKSGQHKGYSRLREALQKNLRFQLTILAVSVVGVIYLSLEVGLSFGHMKSMIIALSHIYPLVLALWLMAHGLVNIPRDQWTFGSVVGNLNFHYLKVPKLIDDLEDVKIAFKEDILQVLVLQKNFTHDSEDLFVFRDWILEMYQNIPEDLKEVMELQYVSEAPAISRNQLTSGFMTKLTARFNSNLHKLVAYESAFNTLYRHVILYEDLLTTTSGSPQFRLDTASDLVSPRTKYLLHCYVYPVLNRAWSIMLFGAAFVVIESELFHSTKLSLINMIFTRIHHNWVQLVVCWSVFSLMLICAMNSLTKLKVFSVYHLVPHQSDPVSACFYATYIARLTIPLSYNFITLFVSRKSIFEDWFGKSIHLTGLFNLMNNWIPRLIVLPVVLTVFNVYDKLKRRLGLASDLYDSFGFDDVEDVENQPQKRKDLIIVEAKRIISREYTKRMAGNVRHFNLQQAADLNYNVNRTQFTAALSNRIDEPYHDEESSGSESIWGRLGSQWSNLTQQLPRWSDRGLGRRRGSSAAYEDEPLDQFDYDDDADSPMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3K1</accession>
    <name>G3B3K1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114237</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3K1"/>
    <dbReference type="STRING" id="590646.G3B3K1"/>
    <dbReference type="GeneID" id="18247327"/>
    <dbReference type="KEGG" id="cten:18247327"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_1_1"/>
    <dbReference type="OrthoDB" id="4031310at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="280" mass="31521" checksum="B84290905CAB8202" modified="2011-11-16" version="1">MSTPIIINDNPSIPHYSIQSTFKKSSCSSKIVVVGDGGCGKTCLLVSYTQQKFPEIYVPTIFENYVATVHSPSGRPIELALWDTAGQEEYDRLRPLSYHDVDVLLICFSLDNLTSLQNVKDIWFPEVNHFCPGIPILLVGTKADLTNGSIDPDLPIQLAYEINAIGYIQCSAKSMFNVATVFDFAIDHYLTKYEAWEKDQQSKKRLSFLGHSRGASRSSAGSKGHFKNSSIDSSVFHMPLAEEESRNPYTTNPYTSTQRYDNTEFEYATRETKKRRCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3L9</accession>
    <name>G3B3L9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_104624</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3L9"/>
    <dbReference type="STRING" id="590646.G3B3L9"/>
    <dbReference type="GeneID" id="18245737"/>
    <dbReference type="KEGG" id="cten:18245737"/>
    <dbReference type="eggNOG" id="KOG3138">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_5_3_1"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="173" mass="19346" checksum="F0AB17C58B55AB66" modified="2011-11-16" version="1">MARSITSLDDVTANNLGTFKKINQVSLPTSYSEAWYKEALNSDQIVKLAFFSELPVGGVKAKPLNLSSDLATFDSAVGAKLVPKMVPNVVYIETLAVLTAYQNLGVGKQLLDHVIDQTKQKYIHDVCVHVHVTNTHALEWYEKHGFEQKSLVKDYYKLQGLESPDAYLLYLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3R6</accession>
    <name>G3B3R6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_122567</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686533.1">
        <property type="nucleotide sequence ID" value="XM_006686470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3R6"/>
    <dbReference type="GeneID" id="18248907"/>
    <dbReference type="KEGG" id="cten:18248907"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="583" mass="64409" checksum="FA3B69B1E2CBD05E" modified="2011-11-16" version="1">MTEINEAAVEKPVAAVNAIEEEKPKFQWRVVDNHSPPEIYNWRLYLCIAVFGLLGSLRGVDEGNTASTSLPSFRAKFGLDDPNKSEGAISNLTSNIKSMVQLGSILGALISTFSVDKLGRVKSLQLACVLMVVAAVIQMTSKNIGQLYAGRFLEGALSVGLTVAIGPPYMSEVTPKAIRGMAGCVFAGAVYFGIMISYFAVYGCVTTISDDSNLQWITPLCVKIIVPGVILVGSFFAIESPRWLIKTGKNEEALKALARLRNLSESHPFIIGEITDITESVHQELEAKKYNSFLGLFTKLVRVKSLRYRFFALGCMVQILGQWSGANSITIYAADLFAFSGIKGNDQLKMTAILGVVKFVAAYLGAFFVIDFIGRRKTMYLGLAFQGLSILYFALFLVIVPEAANEDTILVGSKFRASQGAMAALYLGGVGWVIGFNSLQYLIGSEIFPLNIRTFAQSLIMVLHFANQYGNSKAVAKMLIALKPYGTFFLFVAVNVISLAWAWFFIPELSGRSLESMEEMFNLPWYQIGRNGPKLCPDHSEINKMDYSKGTLRYLDEKPSEEFYEDGVKVERRFSEEKEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3W2</accession>
    <name>G3B3W2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_97805</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3W2"/>
    <dbReference type="STRING" id="590646.G3B3W2"/>
    <dbReference type="GeneID" id="18250715"/>
    <dbReference type="KEGG" id="cten:18250715"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_82_4_1"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000714">
        <property type="entry name" value="Nitrogen permease regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000919">
        <property type="entry name" value="NPR1p Protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF113">
        <property type="entry name" value="NITROGEN PERMEASE REACTIVATOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="412"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="776" mass="84435" checksum="7E20AADA65EF1132" modified="2011-11-16" version="1">MQAEKDKLPVSSLTRLLNESNSNQASPQQSNNASTSSLKDGLLKTSPSSNSSDGITFNTKTLEPQEVGTEDSDIGQTNETDAFDSELVSESPKSKLSSLNRVIPIKPPINASPRVVRTNSLGHSSFLNYSESLSNSIPYSAPGGRGNSTLSQSANSTSSLNTLGSLSEAPGPASISSGSASGGSSHVPNLPNGQPISSIHISSPQVSSSSIDQRFVVSKQRVAQAHAASMGSSQRTGSQSGLSYFFSGKSKPIKRPGSSTDLGSFYNNSFQEQQGQMFSGSPSSLSSSDSYFPNQSRHNSMVNLKRFFKKSSTSPNTTTVSNLSSSLRSTPGSLSNTPITSYNLTANSTNSSYASQGQSMPTSPIAGNYSNGFSNSYSNSLQNKINYQHDRRGSVTSLVNLHPQLPFSKRYSKYGENLGAGAGGSVRLVTRISDKQLFAVKEFRNKYQNETKRDYAKKITGEYCIGSTLKHPNIIETIEICYENDHILQVMEYCDYDLFAIVMSNKMSREEINCCFKQILSGVHYLHTMGLAHRDLKLDNCVIDKRGIVKIIDFGSAVVFSYPFTKTLIEAQGIVGSDPYLAPEVCVFNKYDPRPVDVWSTAIIYCCMMLKKFPWKVPKLSDNSFKLFASRGEMIPISETLKRTPADLAALPHHTTNGEGLGDLSDIAEAVETDPETQGKSHTSNEVGEGRLLLALPEDCRPLIGRMVELAPACRITIDEVLQDSWLQGVQMCTVEERVLSDGTSVSERVRCEDHDHTQVDQSKAHIAAFEKNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4C5</accession>
    <name>G3B4C5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_113975</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573</strain>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Also acts on 2-methylisocitrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4C5"/>
    <dbReference type="STRING" id="590646.G3B4C5"/>
    <dbReference type="GeneID" id="18247202"/>
    <dbReference type="KEGG" id="cten:18247202"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="430"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="551" mass="62149" checksum="7AAF65F01A645E0D" modified="2011-11-16" version="1">MAYSKINVEDEEKFYQQQVQEIDQWWKDSRWHKTKRVYKPEDIAQKRGSLKIEYPSNNQAKKLYKLLEQHDKEKSVSFTFGALDPVHVSQMAKYLDSIYVSGWQCSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQREERLKLSKSERANTPYIDFLRPIIADADTGHGGITAIIKLTKMFVERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADILGSDLLAVARTDSEAATLITSTIDHRDHYFVQGSTNPNTPDLSTLMHEAEQSGLYGEQLQAIEDEWIKKAGLKLFHEAVIDEINASSISDKQGAIKKFTTQINPLAEASHKEARKLAKEILGKDVYFNWDVSRTREGYYRYRGGTQCAVMRGRAFSPYADLVWMESALPDFKQAKEFAEGVKSKYPNQWLAYNLSPSFNWNKAMSPDEQETYIKRLGKLGFVWQFITLAGLHTTALAVDEFANNYSTIGMRAYGQLVQQPEIEKGVEVVKHQKWSGAEYIDGLLKMVTGGVSSTAAMGKGVTEDQFKEKASGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4F3</accession>
    <name>G3B4F3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_121505</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4F3"/>
    <dbReference type="STRING" id="590646.G3B4F3"/>
    <dbReference type="eggNOG" id="KOG0431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362080_0_0_1"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="733" mass="81978" checksum="3040C03994B79D4F" modified="2011-11-16" version="1">MAPPKKDVFADLFPAGNTTTANRRKNLADLQKDRYGNNSNAGNMGMDIFDSLNSSKASFPVESSTNTWDEIGTSTSGSREDPFDIFKEPSVASNSTSNKASTINSVKPTKPTNNPQNNAHSLLDDEFTDAFQEEPQPAPISKSVPEKESFEPYSEDLRSNSSSSLSKRDELIAQLVDIGFPVEVSDSAISEVGMDLQACVNYIMNGGNSRSSSSSQPSLPRTRTHSPNKEDLGAKLNDLSTDFFNKASIFLNKSKETVIKNIEQFQQAQTTGRGSPSNSLPVWMQDSEKEKYKKREAEFFGKSDNDYSADEANIDHEFISNFMEEQKQKQKARNKARVDNLKAMAKNKIYGASPTKSPSPEKAELPPRPLSNPSRERVPATTKADAPRKEQAHQLTSKTQQTKAPQPDVDLLGVGGSLSRAENKPKASRKTTREPLDQFSQSDYDIGKEKATKSFANGDYDDALINYEKCLNVLTPTHELRLVINSNLALTLIKLGSYKQARDQCDQALHLINIEDINDESYVINDKPVKYWYIKLLSRKAEALEMIEAFSDSLECYMELVTKLGVNDKKVMDARRRVNNIVNPPPKPKPSVSRPKPSRIQPVNNDNLKRVQAQNKKQEDRDSLKYQLHDQVESKTSAWSNGKEDNLRSLLMSLPEILPASLGFPFLTSKKITINDLMLPKKVKINYMKVISSIHPDKLTSLNLGVEEEMLCQSIFITLNKSWDIFKEQNGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4L1</accession>
    <name>G3B4L1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_105081</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4L1"/>
    <dbReference type="STRING" id="590646.G3B4L1"/>
    <dbReference type="GeneID" id="18245775"/>
    <dbReference type="KEGG" id="cten:18245775"/>
    <dbReference type="eggNOG" id="ENOG502R366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191645_0_0_1"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442726" evidence="1">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="86" mass="9668" checksum="D4188A194A131607" modified="2011-11-16" version="1">MWLSIFLVSSVVTTSCNRDFRNVFPNNMSHENANSMVTELVRLLNVDEVDDVTLQLCIKLLDQGVDPKQLARDILSIKNETTSAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4N2</accession>
    <name>G3B4N2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114019</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4N2"/>
    <dbReference type="STRING" id="590646.G3B4N2"/>
    <dbReference type="GeneID" id="18247220"/>
    <dbReference type="KEGG" id="cten:18247220"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024893_1_1_1"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF9">
        <property type="entry name" value="CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833552" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="385" mass="40060" checksum="263BEB65BE0E76CA" modified="2011-11-16" version="1">MLQLAQTLALSLLLLPTHAAFSSYGCFPKSSVESLLTYGDEYTFQSSGHCEGICSGSRYAALIEGSTCYCGSIEIDSSDEVSSSNCDTTCQGYGSENCGGSDYFLIYEDASVSASAVASSSSTAQSSSTSSSSSSSKTSSTHKTTSTEASFSTDVESSTTSEADDESSSASSTDNTSQVVSTVTSDSKPSEVTITKTKDSESSPTASTSDSGSSSASATGHSDDTSKSSSGSSKKSLSGGAIGGIVVGVVGGIGLLAGLLFFLWYRRRHSDDDEDDFEKDAEGFHAVPPLNRTGGKSEYNVTPNSFVGKKPTIKSEHTKQQSLNNNSFGSNDEYFMFEDARVASVGHGQGAGVLPYPTEDYGRRRLSDGSLPDMITKGSLKVVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Y7</accession>
    <name>G3B4Y7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114054</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686640.1">
        <property type="nucleotide sequence ID" value="XM_006686577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Y7"/>
    <dbReference type="STRING" id="590646.G3B4Y7"/>
    <dbReference type="GeneID" id="18247234"/>
    <dbReference type="KEGG" id="cten:18247234"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737695_0_0_1"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="375" mass="42180" checksum="FE27C7C048112FD5" modified="2011-11-16" version="1">MAEKRLFKELNQLSKVAPNYSNHQILSLAPKDVESSVYEWQSVICKPSKIDSKFYHNGQWTLNISVPQQYPIVPPKISFSGATPIFHPNINVDTGEICLDILKSESWTPAWNLEHLVVAILVLIDDPEPDSPLNIDSANLFRHDKAGFESFAQYTIWKHGTFYEGERARSGAKAGQQDDIISQDQELEIALQENSSKSINVIKDVGKQITQEFINKVDEITHSKQNSVDSIDHNVDYNNAKKYIAEKVNRQVLELCSKSVSPVNEIEGPEEPLDPIVEGEKLRFLQEVDSKVQSFSDAAKEASASEKVSTVSSTSSKDNETISAQSSHSNVDKLKKSMSIRSFRSDTSGGSSNKKKHKKRDKLKEFLKRTEEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5G3</accession>
    <name>G3B5G3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_106757</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5G3"/>
    <dbReference type="STRING" id="590646.G3B5G3"/>
    <dbReference type="eggNOG" id="KOG1773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107649_5_0_1"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="80" mass="9201" checksum="DE0BFC9C3D77B05F" modified="2011-11-16" version="1">MHPQDWFMVFIGFFFPPIPVLVKRGFFSADFLINIVLCLLGFFPGLLHCYYIISSYPYRETHSALGGDGHNHRVNNYGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5G7</accession>
    <name>G3B5G7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_93989</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687013.1">
        <property type="nucleotide sequence ID" value="XM_006686950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5G7"/>
    <dbReference type="GeneID" id="18250346"/>
    <dbReference type="KEGG" id="cten:18250346"/>
    <dbReference type="eggNOG" id="ENOG502T4DI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573784_0_0_1"/>
    <dbReference type="OrthoDB" id="4095869at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="419" mass="47890" checksum="112F7F514A2E850A" modified="2011-11-16" version="1">MAGEEYNSNLDLAEVFNTIDEIFGTIETYQPPSSDHIYPELILQESQHGMKYHSSFQRHNRQFIQNAGETPLVRWRNSHIEQLQQQVVEQSFMGSKVSSQKGISKTFSRPASNALFSWSSDEAYIEARKSELLKRGRKISGAFLKSNDKDSEIEMPEVSSAPLTESLIDRVNLKIPEASMIKKLNSVIDTESNRFVHQRIQIIKTHHSKQISKKINERKRKDHEIHLQRLKLKEEQYEREMRAATEDKEKEKSTKFLGLFNFSHSDTTNVNVETKEPTSPNGTTDKNRITVDKNKQRFSFLPKTNIFGTTKTTNEDIEENTQESNVSSPQIHIASDDLDKAFQMPGTNKDSQDDDFDDFSEFTSSPPQATSNQLPEPVVKNHRFMTISEPKPLIDFGADAEGDSQSNFKGQNKDLLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5M7</accession>
    <name>G3B5M7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_106606</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687059.1">
        <property type="nucleotide sequence ID" value="XM_006686996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5M7"/>
    <dbReference type="STRING" id="590646.G3B5M7"/>
    <dbReference type="GeneID" id="18245903"/>
    <dbReference type="KEGG" id="cten:18245903"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_7_1_1"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="456"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="887" mass="102435" checksum="9F3C6002FACAC652" modified="2011-11-16" version="1">MLPPGSRTSKIKPPRKSITNSSLTNTQAFDFNKSWDVLSSAIVQIQNKNVSNLSYEQLYRKAYTLVLHKFGNRLYENVEELIETHLLRRRTKLLSIFSQSSSASFVNVDEEFIKNVLSEWNEHLQAMKFISDVLMYLNRVYIKEQNRLLIYDLGIKLYKDCIIKYNDNEVGTRIINILINEIQKNRNGEIISTKMYITNIIGMFELLHEDNTQNDLSVFENYYQKYFEPVFLSTSNDYFNNLIEKFLNYGSGLKYLIETNQFLSDEIDRIDLYLPESTVPKLIDLMNNTLIKSQLDNIINFPSDSLQSWIQPIKDNIILGEPTDSGIPIDNDSLNYLKILYSFNSRIDSSCELLKVRLKDIIIKEGKQFPSLIKNLLNSGELGERKKPISPNSPAFANKWIGSILLYKAQFSKIVKDAFDHDYSMEQCIISAIQEFINLNAKSKKNNNDFSLLIVNPSELLSVCMDNHIKQYLKPNSIAGSRDKGITSNDASFSSIDEFINKSLQFLRFIVDKDTFEAYYKNHFAKRFLNAKGFNQDGSTGIDIEDFVISKLSEELGTTSLDTIIKMNMDIKSSRGVTSEWKNFLVENKDKSIIDMDLKICNISYWPNSMTKDYKKLSGKQMNPDSSTTFIWPRRIKHTIQRFESFWTIDKKNSNKSLYWCPKFGSMDLKITYPSKTFEINLPTYAGVVLLLFGPSYSLDSDSEVNSEDFNPFKDKKKLTYKEIEELTGIPEVELKRHLQSIAVASRSRLLTKTPMSKDVNDNDIFELNEKFKSPSTKVKVLTVSASSSTNTAGGDGRLRKSRDEELEDIESSIAEGRKHEINAATVRILKSRQSIYHNELVTEIIRQLQGRFLPNNSQIKRHLEDLIEKEYLKRDDNNRNLYHYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5S2</accession>
    <name>G3B5S2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114589</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5S2"/>
    <dbReference type="STRING" id="590646.G3B5S2"/>
    <dbReference type="GeneID" id="18247491"/>
    <dbReference type="KEGG" id="cten:18247491"/>
    <dbReference type="eggNOG" id="KOG1709">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033831_0_0_1"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000310">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="7">
        <location>
            <begin position="182"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="408" mass="46954" checksum="47DEEA3E91E0EEAC" modified="2011-11-16" version="1">MSDLHDLCRFISRPVTNQYITQLKAYLKSGIPSTYTVEEAYNYTNGIEEEPTTTTTPLHIICQNIPTNGTEEELLVVSEMISVLFEYGAGWSFTDINNETPGCILIKRNMKDSVAFNQIVEAGVRAELILRKVNDNIEFIEASDEEEVPELVESEEQTENAQEDISQIKGNTLEVDPQSTNLDPAEHQETYLNTKLQYKDDALVTSNKDGVMMSWEHNLMQMGCNSLFKNREDDPEEEMVVLNIGFGMGIIDTMIQDKKPFKHYICEPHPDVLEKLKKDGWYQKPNVVILEGRWQDKVAELLSEGVFFNGIYYDTYSEHYSDMLELFDLIVGLLKPQGIFSFFNGLGADRQVIYEVYKKLVEIDLSNYGLQISFTDINLPTLEVWDDIKRSYWNCPVYYHPEVKFVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B600</accession>
    <name>G3B600_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SUN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_98479</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B600"/>
    <dbReference type="STRING" id="590646.G3B600"/>
    <dbReference type="GeneID" id="18250777"/>
    <dbReference type="KEGG" id="cten:18250777"/>
    <dbReference type="eggNOG" id="ENOG502QREM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033459_0_0_1"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="378" mass="39073" checksum="3D984BDCB1619079" modified="2011-11-16" version="1">MAAPANHNHQHVHLNKRAVVTTVVYVDVQGHTIQGPDATSTAAIASSIVETTSTSSTPTPTSTSTQADSTQAASTQAASSTQAASSAPQSTETSSSSGSSSGSGGISGDLGNFVDPTEKFEDGVYDCDTLPTGQGVIAIDWLSNLNGGFSSIMNENGDTSSTCQDGYYCSYACQAGMSKTQWPSEQPSSGISVGGLYCKNGKLYKSNSNSDYLCEWGTQNANFVSEISKDVAICRTDYPGSENMNIPTLLSAGGTAPVSVVDSSTYYTWKGGKTSTQYYVNNAGVSVEDGCIWGTDGSGVGNWAPVVLGAGTTDGNTYLSLIPNPNNEEQPNYNIKIVAADGGSVIGDCKYENGQYNGSGSDGCTVTLTSGSAKFVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B615</accession>
    <name>G3B615_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">PTR2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_135183</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B615"/>
    <dbReference type="STRING" id="590646.G3B615"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_3_1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000003">
        <property type="entry name" value="60S ribosomal protein L22-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="87732" checksum="9B0FC644304D4419" modified="2011-11-16" version="1">MSVDLKEKPVTPPVTDDKSQTLNEESWSDNISEAEDYDFDDERNYNTNYVDELNPRGLRFPTKEESRTLRRVLGHAPTVVYLICLVELAERASYYSTQGLLTNFIQRPLPAGSTTGSVPKGPGSGDLSAGALGMGLQTATALTLLLTFLAYVVPLYGGYIADTKIGKLKAIWIGVGAGFISHVLFIIAGIPSVISSGHAIAPTILAILSLCFGTGFIKPNLLPLIMNQYRFETDVVKVLASGEKVIVDREKTLERMTLFFYWCINIGAFFQLATSYCARDVGYWLAFFVPIIMYLVLPLVLFFVGPRLIKEEVQGSVMTEFVKILRVSYQRGWIARLKSGEFWEWAKPTNMVARGVTTYRKTKAITWTDQWVLDIKQTINACKIFIYFPIYLMNDGGIGSIQTSQAGSMSLNGVPNDLFNNFNPLAIIIFIPILDYLIYPLLRKNKIDFKPVHRITLGFVIAALSQVAGAVVQHFIYKKSPCGNHASSEGCTAPISAWVEVLLYIMQAVSECFANTTSYELAYTRSPPHLKSLVMSICLFMSAISAAISQAITPALTDPHITWAFVAMAIIGVLFAVAFFLHFRNLHIEMEQERILREAAERQFSTMISHGGLENDKNLEAVTSIKSAVVYERSGLSPMVKKSFSYSTTSVFFIMAPIMAKGFDISLVRTSKKSKTAKKFVVDCSAPIENDVFDQEAYVKYLVEHIKVEGIVGNLGDDISVTAEGNKVVVVSNAKFSGKYLKYLTKRYLKKNQIRDWIRFVSVKQNQYKLQFYNVGEDEEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6A5</accession>
    <name>G3B6A5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_123654</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687215.1">
        <property type="nucleotide sequence ID" value="XM_006687152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6A5"/>
    <dbReference type="STRING" id="590646.G3B6A5"/>
    <dbReference type="GeneID" id="18248968"/>
    <dbReference type="KEGG" id="cten:18248968"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="122"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="637" mass="71735" checksum="E301304CFAB4E5A1" modified="2011-11-16" version="1">MVFVDTAAKKSGLLDSTSSSASVEDKTRIPEDLDSIHSKLAEPGYGEKGNILSQYSESQVMQMGRNYASKHNLDLDLFGRAAALARAPLQFNAMPFVTDAEKEGLHKEATRKWHVPYKLVQVIALGSMAAAVQGMDQSVINGATLYYVDQLGVSSMANPDLLEGFINGAPYLAASCIACWTSDYWNRKLGRKWVIFWTCLISGVTCVWQGFVNTWWHLFIARFCMGFGVGIKSATVPPYAAECTPRQIRGALVMLWQFFTAVGIMLGYVASLAFYTVPDRGVAYGLNWRLMLGSAGIPAFIVLVQVPFVPESPRWLMGKGRHSEAYESLAKLRHEKIAAARDCFYQHVLLQEEGSYVGVPFYRKVWEMFSVRRNRNGALGAWIVMFMQQFCGINVIAYYSSSIFVESGLGVREALIASWGFGMLNFLFALPAFYTIDTFGRRNLLLTTFPLMSLFLLITMCGFWIDQETNPNGRIGLIAFGIYVYTCIYSSGEGPVPFTYSAEAFPLYIRDLGMGFATATCWFFNFILAFTWPRLRNAFTPQGAFGFYAAWNIVGFFLVLLFLPETKGLTLEELDEVFGVSLKKHAAYRLREFNQNVIQKGILRRRVKEIEPLYEHQKRMAVTNVEWNEKTEVSHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6E7</accession>
    <name>G3B6E7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114766</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687241.1">
        <property type="nucleotide sequence ID" value="XM_006687178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6E7"/>
    <dbReference type="STRING" id="590646.G3B6E7"/>
    <dbReference type="GeneID" id="18247566"/>
    <dbReference type="KEGG" id="cten:18247566"/>
    <dbReference type="eggNOG" id="KOG4455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110781_4_1_1"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="104" mass="11727" checksum="D16272706E152F8D" modified="2011-11-16" version="1">MSDKEIIFYGPSVEKNRTKLQYVHHVMCLSLGVAAGVLSLESFMGFVFYAAGMTATNLGFVAVCCHGKPRQFFRFPLQEVFWDGIQSNIAGYIMMWCLVYALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6H0</accession>
    <name>G3B6H0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_135274</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6H0"/>
    <dbReference type="eggNOG" id="ENOG502SVZ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_744271_0_0_1"/>
    <dbReference type="OrthoDB" id="4096984at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="379" mass="43691" checksum="8936998F2C2547DD" modified="2011-11-16" version="1">MHSRFPFLLRQLSSRPDHFSRYPLNNESLVKRINWFKSASSSLPPPSIFPMLIDAINATRQIQLQNTPQVHQSDFLSISPSESNDDLENQLVQLLQHYKSHWNSTNHLIRHYLHEPPRPNSASVVDLVSSSFLSQLQYGRVDYGLVRSGIDNLLHTNDYASSFKLVDATLYAPQFTQHSSRVLRRTLSWVSAAFLAVNVLEIAILPLISPAFLVLANTALAVSLGYGFTNLKFPRHLGRVSWRMSKSPRQGVLHNEELFLVNRIITYFEENNEINLKNYHTSQVREFSNPNISRFNDYFVELPTSTAVTAVGQHGQYIDENIVALQQMFRRELIGRKIAINDLPEELHFVEFWMTQGENFEWVEPDQDPAEIVRFRKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6I1</accession>
    <name>G3B6I1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114787</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6I1"/>
    <dbReference type="eggNOG" id="ENOG502SD6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061727_0_0_1"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="262" mass="30362" checksum="C1A295C2090300CB" modified="2011-11-16" version="1">MSYVFDNSVELFGKNYDYVLTAANERYMIKTHSFLTSFFIRLIHQKQLLTFKTFEPDSAERLQAINQLFNLILVEAELFVGNFRLLSLRYVNSYKIYVLTYYVLKQCMQNAEVFFAYALSDVSTILDTTNMLQYFSASEIKYLCKLCEEFRFAKDNQHRQRRANEMFNMNFQHGGTFEDEDLKDKPTEEEAISPSDNRGGDVNGMEKDVSSVLRGQTDTPMGGLDSVLSSMNFGSFSDANFKSDDFMKFFELYGDPSNPHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6I2</accession>
    <name>G3B6I2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_130920</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6I2"/>
    <dbReference type="STRING" id="590646.G3B6I2"/>
    <dbReference type="GeneID" id="18249487"/>
    <dbReference type="KEGG" id="cten:18249487"/>
    <dbReference type="eggNOG" id="KOG1974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008440_0_0_1"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="11">
        <location>
            <begin position="43"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1137"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1049"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1137"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1158"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1245" mass="142542" checksum="4D843BFB98B56906" modified="2011-11-16" version="1">MREMASVLKPNENHTQKILKAHVSVLVSALGGPDYTSSNVPQPYKLGHDALACLKDIKRWIKSVDERGQSYDVALACADSGLLVNDLTVMLCQWDSQASKGEPIKNARTMEKIMLANLELLVLLTWPTELTPESSESQRLSFSNLRKTQLVYKRHILHYNKGQTLKAVIRLVLATMAKEKADREPKDNAILRLVLFFIRNILYIAPITSSISMKTTKDLASLDSMPAGVTTEDISMSTVLNCFKRNKVLMFLLTMSNSVGSDFDKQMFGPACLECIYLLVKNIQVEHIISPVKLDKHPQTNPAPVSSESAAGSQLTDLLKEETKRKISQKQHLSTRHGRFGSLLSIQGDEQSYVISGQEALLNANSSLDKLDRSKKWTKPKSFRYDSDEFTRGERLYLNTGSILILKEFINQFLAGACFNNLISNTSSLFSSADDLITIDPYERAVYFLTLAWFLRYKRERNQLLKDNPKMLENLTDDDDSVNFSSIRAALSQTNFILILHYFRNSYTIKEWSSVHVAMIAFLELLLISHTLFISKPKEVEADEEESQEELDKELGEGIIRNLFTSNDFLNVLVQLPQSASKHSPEYLKTCIHIVHILLKSFESFTKENVKLYIQKRRRKVKRRGEGANDMDGRILHRLEERGMGYSEDEEADEERAKEEKIERELDLAKTEIRFFHTATVTSYIDYLAEYEELTHEEIKRCLSYFHRLFVVKKDHSALYRLDFMYVLHRLRSYLPRSSSMRNHVDEFIVYFMKKFKVAFARFPNPIEILFPRFEEHEIKTFLTTGELTSRYSESKSQPKLARQIDFIREFSFEEKVKILITALYLEEKEAFIAWLISALDAIIQKRLLDVASGSTEDARAISLQAPDKFRRLLINNPQIRCLLTLVKFDLPDILEENCEIPGSVTSAKLVEFLEFIKKYIAAQPVNFEDGKDAFFFLITKDSYGYDDDYDINYRGYDPEDESIAFETAGNQEKSHYMEELDQLDRLEASISSVGHGQLGVARKKRKEKANKPPKKSSRAPKETGPRGSRPRQPVALPQHFTKSAEFINDSDDDSDEEKDEEFFAREEKLRRLLSESGGIVNSTQLEDFKKVWKILATDTDKDLETSVNKAVANATDNLRASQHQQSQDLFGSFSDTQTQTQTQTQFSNDDENNVNNSTRLSYSSESDLSSDEETLTNDVDESLTRDENKENETPTGTQVNPRKRPMVFSDNESDDENVSFVSASGDVSLRKRKIVLDDDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6V4</accession>
    <name>G3B6V4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHP domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114336</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6V4"/>
    <dbReference type="STRING" id="590646.G3B6V4"/>
    <dbReference type="GeneID" id="18247378"/>
    <dbReference type="KEGG" id="cten:18247378"/>
    <dbReference type="eggNOG" id="KOG2363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048451_3_0_1"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="290" mass="32846" checksum="9C36F3A681C71CAF" modified="2011-11-16" version="1">MYDLNVPWPRNNYEKLTDEQVVGLRNVIVTLYSLKVYKVAINFEIDESIRLPVNSPQEINPIKVPEIIDVAKFPGLSVYTRLTVVVNDSSKLVSFNKFQNYFDLVAIKPVSEKALQLSIINLNIDLISVALSSRLNFYLKHKIVGQAIKKGVKFEICYDSLISSSSSMSRKHLISNLIQLIRATRSNGVVIAGGCTDAINVRSLNNIVNFFETLGLKRNKINQFIENSRYVLMNGRLRINSYKQVIALDDDDELLDNSKDDPMGNSVVNGYKKQKRKGDADEQTVKRTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6W2</accession>
    <name>G3B6W2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114339</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6W2"/>
    <dbReference type="STRING" id="590646.G3B6W2"/>
    <dbReference type="eggNOG" id="KOG4339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1343080_0_0_1"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="204" mass="23194" checksum="288715B4A6C20349" modified="2011-11-16" version="1">MSFKGLKGPSFGNKLSTKALRESESHQSFNMTFNDDDSDLSGSAVGGGFGSSDEEEEEELDLDEYNYNQYYNDQYDSEEEELENQQEEKENFSHFQPPPPLTQKSKRNNIGSPESFASSNLGRSSNFTASPRSVVPKKKSNGVRFSSRIILYDTYNGDEYDRHPDLATCNQLTPMLAQMIREEVNEIKANMPVHELSRCNTHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B740</accession>
    <name>G3B740_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114402</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B740"/>
    <dbReference type="eggNOG" id="ENOG502TBYA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1384126_0_0_1"/>
    <dbReference type="OrthoDB" id="4020802at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="220" mass="24466" checksum="AE859BA4341763B7" modified="2011-11-16" version="1">MNDLLSSLKQGKRFQRFDDLRSDQILQWYCCDCGQSYGTVMYQDHLIDLAQQQQHLILAKATSPGRGLSPPSSPAATPPEPQETQSISSSQSTPIKRYKSLLYSLSDRESLMNLLSGLASPAGENTVSNSDDDDDTELEEYAYHSNSELSHSTEVPLAANYTLESPDASLLAANGHGHRAYPSNLSQYLVSIPERFTCNRCCHMMCPYCLKLRCRDICST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B768</accession>
    <name>G3B768_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_123862</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996526">
        <property type="protein sequence ID" value="EGV62965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996526">
        <property type="protein sequence ID" value="EGV62966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687510.1">
        <property type="nucleotide sequence ID" value="XM_006687447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B768"/>
    <dbReference type="STRING" id="590646.G3B768"/>
    <dbReference type="GeneID" id="18248986"/>
    <dbReference type="KEGG" id="cten:18248986"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_2_0_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF26">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G13940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="350" mass="38709" checksum="D15950ED16BCF7D1" modified="2011-11-16" version="1">MSENIVIVGAGVIGLTIAYQLVTENGYDATSVNIIASDFPSTGSDCPEYTSSKSGAHFRPFPSKSPQELRDSKLARPTYKFFKKLAVTNPESSVKWIQGFDYLENNDTLYETTAAGYTEDIDNFKIIEKSQLPRGIEFGASYDTWAMNSPKYLEFLENTLSMKYGVNFVREKVESLKQVCQLYPGALLFNCTGRGLQFNGGFDPNSYSIRGQTLLVRAPLGCQYLNKTITYQLANGSWIFVIPRPLNGGIILGGTKQIGNLNSNPSQNDTEHLIKLGEAYFPDLMIEGKFDIRRVNVGFRPARNGGTRISSYKEDGVQVIDCYGFGGSGMEMSWGAAMRAIGLIDHGFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7P8</accession>
    <name>G3B7P8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_99314</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Exact function not known, phosphatase 2A performs an essential cellular function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7P8"/>
    <dbReference type="STRING" id="590646.G3B7P8"/>
    <dbReference type="GeneID" id="18250846"/>
    <dbReference type="KEGG" id="cten:18250846"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="148"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="343" mass="39103" checksum="DE66108DEB019BD8" modified="2011-11-16" version="1">MDLDTDVPMEDVSDDHSETYQGGAKIDASKSKPSELTGDSVNQLDQWIEKLANCEPLSEQDVKRLCDMAVDVLQFEENVQPVQVPVTICGDVHGQFHDLMELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSFLVCMKVRYPNRITILRGNHESRQITQVYGFYDECLRKYGSANVWKVFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQSVVTIFSAPNYCYRCGNQAAIMEVDEMHNRQFLQYDPSIRPGEPTVTRKTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Q4</accession>
    <name>G3B7Q4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_126001</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Q4"/>
    <dbReference type="STRING" id="590646.G3B7Q4"/>
    <dbReference type="GeneID" id="18249141"/>
    <dbReference type="KEGG" id="cten:18249141"/>
    <dbReference type="eggNOG" id="KOG4539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043838_2_0_1"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="339" mass="38143" checksum="D2331F70A6E9C591" modified="2011-11-16" version="1">MIRPSLTQVGPRVSSTPHVPRPAFAVAARFSSTASGPLNPDSIFVISVPITTKRSYVYCNHKPRVLSEAQARHFPLATRLESKLTGAALKVWTKLSTSKASINIKITALAKRMLDTVAYQENCLRSFPSKDAMIREINQEALSKNQPDPLVVQSHIDQLKIHHSQIKPIPMYHASFQTPGNIISQLEEFKTNSYSTHLKYSILCGIGVPISLPFAIVPVIPNIPGFYLAYRFYCNVKALSGINHLKYLLESSDGTAAGTRHLDFITKPEIDSVYRETNDKSDLYIDSVQEEERLIISPKIIEDLTDKLNIPHLKEELNKAWRQEKSRLKRELKVDDAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7R6</accession>
    <name>G3B7R6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_115770</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7R6"/>
    <dbReference type="STRING" id="590646.G3B7R6"/>
    <dbReference type="eggNOG" id="KOG4748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000117">
        <property type="entry name" value="Glycosyltransferase family 34 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="39913" checksum="7BD437B5F501B98F" modified="2011-11-16" version="1">MEEKLYDSHFKPSSSRYSWTRLTDKVKSITQRAGDSSTYHKILIGVATLLFLSLFTQVPFLPHFRTASPKVVIILAANEGGGVLKWKGPQDWSIERSSIANKKNYAKQHGYALTIKDMTVKKRYSHEWRESWEKVDLMKQTMRQFPEAEWFWWLDLHTFIMEPGLSLEDHFLNDLDNATYRTLDHFNPLALPEDLPYVDYTKQIDLIVTQDCGGFNLGSFLMRRSSWSEMLLDAWWDPALYEQMHMEWEHKEQDALETLYSTSPWVRERTAFLPLRKINAFPPGACSDNADDPQYFYRHHDFVINMAGCEYGRDCWGEMEHYKSLSKRLTRPWWHFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7T3</accession>
    <name>G3B7T3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115779</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689022.1">
        <property type="nucleotide sequence ID" value="XM_006688959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7T3"/>
    <dbReference type="STRING" id="590646.G3B7T3"/>
    <dbReference type="GeneID" id="18248010"/>
    <dbReference type="KEGG" id="cten:18248010"/>
    <dbReference type="eggNOG" id="ENOG502QSJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045155_1_0_1"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42973" checksum="52FE50F19522C528" modified="2011-11-16" version="1">MNYEDVLNENHSLDIPQSVFDTEIQRVVDELTSKPGFDSSLKFDPKRHLDYRGVAKKYGFADLGITNTHVKPINEIAATDPFSLFTIEAVDMMKYEIFSNEALLKKHGRLVSPGHSTGASNLDFNISGFIDDTIFCKAAWNSPELRGIINEIMNDKLTIPHQFSLSHVNVSLADSSKPQLDPDVDYKALKSVNDKMAAGVNWHYDSPPLVCVVMLSAPEEMIGGETGIRLGDESILRIPNTTVGCATMLQGRVIKHIATKPVNNFDRITYVTSFIPEDPNRYDSTCATTERPAVATSFTNDRFYPLYLGYRFDRVEKRLSQYRQMLLQNYEKGAKFDQGKALEFMRDIEQYLRTGYQDFEVLGDKEFPPPLFKKTYSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7W7</accession>
    <name>G3B7W7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115132</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7W7"/>
    <dbReference type="STRING" id="590646.G3B7W7"/>
    <dbReference type="GeneID" id="18247732"/>
    <dbReference type="KEGG" id="cten:18247732"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="49"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="426" mass="47915" checksum="D4305599A6228925" modified="2011-11-16" version="1">MSNRVINFFKGYASNSLHPRKELEAAFSKVLLETDFDKYDTDPDNQHPLNYGTDPGNFDIRQQLSKFMARKFNVPEADPDCFNLTNGASFGIGMALKMATNLEYTKKVFVVSPCYFLINHSFVDAGFSGRIASINETPGAEYEIDIEALEMQLQNIDKENGEDKTGGIFPDPLGRDDNRVYRSVIYIVPTYSNPGGLTYSLKTRLKMIELARRHNMLIICDDVYDLLNYTDDSPLPRLVHLDRETCTDGWGHVVSNASTSKLISPGLRFGWHETATPKLAFQFSQEGNTKSGGTPSQLNSYVIHELLITGTIDDIINNFISHYRERSKVLKDSIKKYLPPSTKFYGGDGGYFIWVTLDPKYNLVKVVSTLAKEHNIILASGTNFEVAENHRGLGDSVRLCFSFLTPPEIEYGIKTFGSLLKEDETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7X4</accession>
    <name>G3B7X4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115137</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7X4"/>
    <dbReference type="STRING" id="590646.G3B7X4"/>
    <dbReference type="MEROPS" id="C19.004"/>
    <dbReference type="GeneID" id="18247736"/>
    <dbReference type="KEGG" id="cten:18247736"/>
    <dbReference type="eggNOG" id="KOG1871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="43"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="428" mass="48827" checksum="4F5E4130FC237EE8" modified="2011-11-16" version="1">MVPLVPVTKATQEIDSVGLLSLKCMFNLLEDSDSSDYFHIYSRGLTNSGNICYMNSILQVLIYCEPFNKLFRILEQKSTGSLNESKTPLIDAIISIFRDFSTSGTKSLSPEGFYMKLSGHRKFQHLKWGQQEDAEEFLGYLLDGLHEELVHSIREVNNEQISLLLETVADNETKLQIKNAIKIIKKLNNSSNGGNDNDNSNDDDDNEGWNEIGGGHKKVSSKRTVEIEPSPIKTIFGGQFRSVLQIPNKKDQSITLDPFQCIQLDIKADQINNIEDAFKQLNEPEQIPFKLNDNKEVLAKKQTFIDSLPDVLVIHLKRFSFENVNNGNIEKLRKKIEYTHKLSIPLELFSNWRKSVNRDYKLTGVVYHHGIIAEGGHYTCDVLRPMTVSDSSRWIRIDDTSINNIDEDDVLSNDDDTKNAYLLFYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8C2</accession>
    <name>G3B8C2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_124798</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8C2"/>
    <dbReference type="HOGENOM" id="CLU_2026416_0_0_1"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="122" mass="12859" checksum="DDE524A2FC654BAF" modified="2011-11-16" version="1">MALINVSLPGVFRASTSMDLIKSLNDSTVCFTEASTAESTDLFNWIKGKCSTVFLTASTGFCNCWAGVASWPKSDTSTGAAGFGGLNLFFVSSNIFSPLEVISSLEGNLASQLDTFLPKPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8P2</accession>
    <name>G3B8P2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115860</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689068.1">
        <property type="nucleotide sequence ID" value="XM_006689005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8P2"/>
    <dbReference type="STRING" id="590646.G3B8P2"/>
    <dbReference type="GeneID" id="18248058"/>
    <dbReference type="KEGG" id="cten:18248058"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="267" mass="28944" checksum="3A003158E3CDF292" modified="2011-11-16" version="1">MVQFNVNGKIALVTGGTRGIGYDIAEYFVLNGIDTIIITSRKPDACKDAKASLEACAASHGKSVKVISEPCDMANDDDLRRFHAIISSQITKLDILIANAGASYGTPFDKHPVAQVRKILDINITGVFHSVQLFASLLENAGSAQDPSRVIIVSSIVAFASDFKDAYGYVASKAGVAHLGRNLALTLAPRNINVNSIAPGFFPTKMTKYLYANKRQETNYGNPRKRWGQKEDIQNAVLWLCSRESNYVNGINLNIDGGLHLVGTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Z1</accession>
    <name>G3B8Z1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Replication termination factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115248</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Z1"/>
    <dbReference type="STRING" id="590646.G3B8Z1"/>
    <dbReference type="GeneID" id="18247793"/>
    <dbReference type="KEGG" id="cten:18247793"/>
    <dbReference type="eggNOG" id="KOG3113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048955_2_1_1"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22724" checksum="680E3A4509B285C7" modified="2011-11-16" version="1">MGNDGGTIAKRQDIINLYKKDIEKHRGDLPEDPVDLSRCVLSHKSLVDEKVVGDSKGNMILKQSILEFLLEKTYKTNQSFAHLKSLNDVLDINPVFEHGQLVCPVSKSSLTFVYLRTCGCVLDHKLITKLVELKSLKCPACQTPYEEVDVVVINPGSQDAEANEEHLKLLSSQGLHHTKKPVKKGKKSKRNHTTSSPTKKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9E8</accession>
    <name>G3B9E8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_115317</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="10"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9E8"/>
    <dbReference type="STRING" id="590646.G3B9E8"/>
    <dbReference type="MEROPS" id="M24.017"/>
    <dbReference type="GeneID" id="18247819"/>
    <dbReference type="KEGG" id="cten:18247819"/>
    <dbReference type="eggNOG" id="KOG2738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_2_1_1"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="368" mass="41125" checksum="8693594D142783BA" modified="2011-11-16" version="1">MAVCASPFCGKDTESTLKCPVCLKQDLENVFCDQKCFRGAWGIHKYIHQQEDGEVYNPFPNFDFKGDLRPHYPLTPRRTIPKHIKLPDHAKGGRPLGELANDRRGKITVLEGKDLEKIRKVGKLGREVLDAVAKHVRIGITTDELDAILHKECTKRNCYPSPLNYFNFPKSFCTSVNEIICHGIPDQTKLKDGDIVNLDVSIYYLGFHADLNETYYVGDKAKADPDTVRLVETTRESVELAIAAVKPGMPFREIGNIIEAFATKNNVSVVRTYCGHGINSLFHCQPDIPHYAKNKAIGIAKPGMVFTIEPMLCLGTYKDVTWPDNWTSSTQDGKYSAQFEHMLLVTEDGCEVLSARQADSPGGPVPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9Z6</accession>
    <name>G3B9Z6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114826</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9Z6"/>
    <dbReference type="STRING" id="590646.G3B9Z6"/>
    <dbReference type="GeneID" id="18247600"/>
    <dbReference type="KEGG" id="cten:18247600"/>
    <dbReference type="eggNOG" id="KOG3191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_0_1"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="5">
        <location>
            <begin position="47"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="220" mass="24818" checksum="391E4D7F0ECFEB41" modified="2011-11-16" version="1">MLPTPILKDLDYDNVYEPSEDSFLLLDCFEDENTFLSQKFGIGSPIITEIGTGSGIVTSFLMKNILPNGFYVATDVNPHACVSSINTIRLNNPDSAKIDVCQMSLTTAILPHTIDILIFNPPYVPAEEVPEIPQQYRDSRWLDLALLGGSDGMEVTWQLLDSLDSIISETGLAYILFCARNKPDLVKLEMEKRMWVVDKIIERKAGWEVLSVLRFMKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA13</accession>
    <name>G3BA13_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase TEL1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATM homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">DNA-damage checkpoint kinase TEL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Serine/threonine-protein kinase tel1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Telomere length regulation protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTEDRAFT_135921</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BA13"/>
    <dbReference type="GeneID" id="18249919"/>
    <dbReference type="KEGG" id="cten:18249919"/>
    <dbReference type="eggNOG" id="KOG0892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_8_1_1"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="22">
        <location>
            <begin position="1747"/>
            <end position="2324"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="21">
        <location>
            <begin position="2423"/>
            <end position="2735"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="23">
        <location>
            <begin position="2737"/>
            <end position="2769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGV61985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="2769" mass="317511" checksum="8976123D43CF84D4" modified="2011-11-16" version="1">MIICSIKKIKQSRIDKIFTDEVMLGDREVIQLLESTKSTDRNKGLKRLSAKRYSSDIKQMMELCKALIHFIEFECLHKTSTSQGRRASACWSLREAIEGIIDYFPPRASVLMTLLTMILTIANGEFLDNILPVITIILKQQYVREHFNEQMWKSAIGFFTSSLQKENDTSLDENLIKGLIVLLNTNDVVYSVIYSLDIKSLIDSLQTVLVRGHNSVSLCSSILVLINRFLAVLSCEQYPLLVELVEMGFRLLSLNKYSFGNRHGINQETIDFLNSEAVYFEIDNLIDTQSDSLSQLSDVISAYVAASIDDLVSTGKPLFVQNVGIIVDHIPVDGYGLNTIQWNNNGDKYYGKDDDSIWFFFVGLSKLIQYFYRINNGSASPNTLGIEEIQGETLLMTQKQGSKRKKRKLSPSTLGSLKQSFDEYEFVQQLMASNNGKYHQVGLQLMILMLELYPITIGSAIGGESNAGATESSTDTEDLDFGTSVLFTSFLTNDEDSIVTAILSSSNDKSLTIWSLIALNSFLCNITSCDYSLSSDTIRSIFKFILPFVRIEQYSEISCNILYHLVEFVMVKEVDPKTISDASLINQVQNIYELANFLGPTSLNDSSLKFWLAFCKLIKFLGLNLRQFQNVVTNWFLHKWDQVFDIEKIDFKITLTNFHIYAYWLTSSEDQWHTINELNEKQIHPLLTTRNKAIRDFAWSSKTLFSNDRPGSNIKGYMIERLNKDEAFDSVISKFFGLIHGFGRMSSYEHMDNFLRFRLIASRLSLFENGYKMVMNYRPDSVSMQLLNAESLDKIISAQGHQDYHALIIEDTWDKIMMTLGYKDIKIDLLTIEAAFQLQHPDLKEMRTILAIVEGNPKLGLAHETDLVKCLMGPSLDASLILIFRLSEIPLVSNSRDIGVKCLFLLGEKFLNNVLYERNELMLVSTCRWVGNMALNLSTESVVLDVLEWLILAADRRLMHTETSCTEYARMLLKILQPKYDEKGELLILDLKGRVEVDTVKSSFLDYFRSITSDSRISLVDDINDLLSSLRSTKEQIEFYKSLINCFQSKNSTGDIGYILFLSLISVINFEIVKSTIFNLLEIGLYKPLENSVRKALQIIRKNCSAGSIKQIFQLARLPIFKSWYLHYRSFNKFPFKYLGYDKKLFYDLYKSELLSVVIASNSNLYEEEINALMNTKKQSLISESLPLAFALAYIPGGIRNEVQKRLIHLSEEDIGKQLARSLDLIVLEVLRLVDTSDLSLAIDYTKISCNFTSFYNTNPNYISMKSGLELVSHLSRKFYSYRDFWNTKRLYFFFRKLIIDLEECISLDQKHTCLRRIILVLILSKKDSETKFSVLNDRVLACLVEKVLPLVHVKRFASDIVSFFALLELNTFDEQDEYTDSLEYNSLVISILSTLVPTKNSSVDSKGVSDILEALACSKKQFEDIISSILQICDDRHDTLSPVDIVPLVSFKVNGSFEPGLKICSFLANKQELIGTSSRSFINAVMQTSISTFSDAFKQICAKTLSDEYFNQGLTIDTKVLDRVYEFDDIEGVKYIDKIIGHIFDYQISSDYSISTLADLTVGQLLEIEESVIASVDENKKEYITKWPETLISSFFKRSVELERKSTEDDLEKWVTQVFINIIDGLPKPQEQFFRIIKNFGHCNKQFIQRCLPYLTCYYLEAKCSEDKVITFVNEFLENSALHSRNSTELILKLILLVRQEARRGVPTFSIVYERLDIEKACSAASKFDFFKTGWLLLEDNHQRTKLSKLQGKNNWYERDYILRIFESIDCEDIMNGFPQKNTLDSALSLMRKGIEFKSTERTKYELGKLETNFILNKSSNTSNLLEAMLTDGLTGTSKVLGESMNLNDTTHCNYEWAWKLNNWTLPIPQKPKSNHEFIYKSLSIVKDQQAVLTESEDSNLTSEIQTKLNSVLVDAVNRKDTILNIHDYKSLHLNLEDFYSTLSILNLILKCCSNTDIQFKEYEQFKDCAFEKIDNIVFSRIMTLKVLKDTRRSQNSNLINALAMYNNMAIKHNKGQKSINTIMTMNELAKDGLKSDLIANVAKYHISKGLWHQNHPIIAVSMMLELKNELPRTLSPFQCDADYSSINDLIVDSTLVEWLSESKQELPTTIMERYFQGDQSTLLRDSSARLISTTHQKLGRFCETQYRSGEINKELAKMDKQVQSKRRELNSIKDHYSKISVPTQEKKAVQKYYTKLKLQYTSESKDNKELKETRVVFLTKAIECYLTSIFRSDDFEVVDKFFSLWFEESKVTELNNMINEKFSSDMITHSHRFMGWISQLISRLSDEPDTDTFQKLIRGLIKEICYKFPFHSLYHLISLKEHASHVNSDEEVMWSKIKAANKIFTSLRNDTNVEYVSKVLDPVYQFCTEAVSLSKYKSQRGKSFDLRKNSKLNTEFWLNLPHIPAPTQTITDNVPVLESIDPIMSIATSGLSLPKIGRFRLSNGKETKILFKYGTDDLRQDAIMEQVFEKVNQIFKNNHESSKRHLQIRTYKIVPIGPNSGIIEFVPNSMALIDIIKPYHERKDKIQLSKARELMKACQNNERSERIKVFKQEIIPKISPVLHDFFFDNFLTPKTWFNSRLCYSRGLSITSIVGHILGLGDRHCNNILLDKRSGEPIHIDLGVAFDQGTRLPIPEMVPFRLTNDLVDGLGITGIKGIFSTSCEVTFTILRENQDHIISILNILKWDPLYSWALSPLRKRKLQSDDGDEGVINEPENDISEAGQAIMTVRDKLQANGLSSETVVRELINTAINPDNLAVIFCGWSPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA60</accession>
    <name>G3BA60_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_99118</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BA60"/>
    <dbReference type="GeneID" id="18250827"/>
    <dbReference type="KEGG" id="cten:18250827"/>
    <dbReference type="eggNOG" id="KOG4522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003142_0_0_1"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="9">
        <location>
            <begin position="159"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1467"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1468"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1628" mass="187016" checksum="BA7E7FF6DC436A3A" modified="2011-11-16" version="1">MSKARSRNSLLLSHSKVAHSLNGTDELSLMKYHLDKPIDSIYPLDSNNSNKDEVKLKHKKGRELTYPDFHPWKDHTQMDDESSRVEIDKMTNSLYLNKGLFEAPQVPNEYYTARNLIQATLFSSGENCFEVLKELSQHLAGVHKTRNEVINKIRADSNNFKLPAKVTLTTLKREAWLADLANDSVPLSKISSRIPHGLKNKVLVDVLCSNSVPIPRAIWFTKCVLYGDAVAIRKKMQNRGESDALESQWLQEWTHQVVDYMYRFSRDFSMVSTPEKKSDIMNKLNYLLKYVQTLYIECLIDKSTLLSSIVRFLKDGLNLEPHYIVQLLLESSKSEANDEEFGTHRDAEINFGQRFLALLLLQVFWIDITKLDYLCKDLSEALLLNYYFISRVPISTSKQSRIPGTLERSLSLKLKESVLGSISDSIRYMFKLNTNAFIIPNYWILIGSTLYQVILGESELMSNQEIEDIQKQLQLIQHRNESLMLNMKHSKSTKEEKPFINSHRRTSSFPAGFTPLNLPFETNVVSPEQKYEELDTLESELFINRSSDDIFRIIDYLDKLKFNEELAKLLRPSLKQKSGNTDWKLNLSVAITWCITIHREPGYSSENILMFCGFLKHRVLAAGSLKYITKIKASIENSILDTIYDLLAGQPQSINFQNLYVLINELYQLKVISISAYLRKLIASGMFFSEPGVELQLNNPSVKMHVNILQNLPVLNNKQCDSILKKWSDPQINFTHKFEHGQSVLKQEVIDKFANNTLVSCNLQNLENLEVGVKYLLVNWMTEEIKKIINSSSKLIHIRFLTVTLLYKVYSSCDNLAVFFKVLVKSVLRNDGKVIVLDMDSLYLIAKLMVRHFKLIKTISGSDTGSVGYEIFRLIMVNYKDLATREPSYLNFKSIWDFIETSFDTKSRSDINADPQLQKPATIPQFIYSKATVDSPMKLNAHTVENRKASTEYSIDEFSSDLNDLTNKSYVFMTTSEVNYAFSALKLGENNETYNGENGSKRFAIVLFDYYMKYGGRLSKEEENLLIRLLINTKHILQAQFFFPFIDCFAYFTQKQIPKFENEQEKLKFTIVAKKLIANEILEIQEVLTIITTIFSNQEMVYNYNSMLHDLVIGDNIQEEQVLTEGQILPLQISRIAFYSKQGAKTLEIIANEIKAQSMEVLSFSISYNQNLEQLFTKWIVTRSRFFMENIKVNFDDDQIISLINRVSGLNTNIHSLDDLLINSSKINEFNLPLFQILFRLILTREMIKISDIERFNQLKMFIETMIPQLRFQFSLDNSFFGELFNSLPSDFKSDVLTILSSILFSHIRLLEDKFKAECEFNGVDILPLLADFFKKFSFSSIESIETTTLVLGGLSDYLSNLLTLLDSMSTPKKQAENESIDRSLSVFIRILIIYKESIAKFILNHDQGFNFLVNLKRLLVSEYFTGCNEKLKILLYDLMLISKNLLAQELNLERGKRNDIKDVIVDTPTNNNAGTPSISGQPSNLTPNQEKSNVFLSQDLVANGQLSKFEKFAAIFDLPDIDNHDILQKYLDDTNIISAVTLQENEINASGDFHIFNNSGLYLVKSSRDSMFSNEPFNLLGEKKKVGDPPKFKISSFEILENTNPEINNGKINLSLFDAYITKQNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAJ2</accession>
    <name>G3BAJ2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_124070</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687586.1">
        <property type="nucleotide sequence ID" value="XM_006687523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAJ2"/>
    <dbReference type="STRING" id="590646.G3BAJ2"/>
    <dbReference type="GeneID" id="18248999"/>
    <dbReference type="KEGG" id="cten:18248999"/>
    <dbReference type="eggNOG" id="KOG1407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071878_0_0_1"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="37681" checksum="226019E7C02D98F2" modified="2011-11-16" version="1">MPPLNTKQQFFQSLKSQTVKDSQLAGSGGYTSEIIFVSVNATSTTVVNSRTDKSLRVWKLTNSGLTESKIIESPHEKSVERIAWHPKHDSTFASVGRDSYVKVWRAHHGKLQQEIKIEKWHSSETPSPVSCQFVSYSPDGRILAVVDRDSTISFLAVGDDYRKVHELHLSQHIYDFQWFNHQHQFFVVALHDGTAPVYEFDDTTTSTKLWTTITGHRSSITSISIDPLGTYFALGSNEGVVSIHRCSTMLVEKTLTDVDDAISCVSISREGSHIGVAFDTTENIRIFEYTSGSQLMEVPNSAAGKSVLPSMCWIPNRTSYIFASSGCTTMTYMYKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAL0</accession>
    <name>G3BAL0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_124103</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAL0"/>
    <dbReference type="STRING" id="590646.G3BAL0"/>
    <dbReference type="GeneID" id="18249004"/>
    <dbReference type="KEGG" id="cten:18249004"/>
    <dbReference type="eggNOG" id="KOG0521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316862_0_0_1"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="521"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="673"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="891" mass="101803" checksum="2C57DE3DE81228D7" modified="2011-11-16" version="1">MDISSLAFPYTQAENTSVTLNRLVLTDDADKLRYVFGLEGDNASKRCTFIYKLETATQLKINEPLTYIDNVSVHKTSPLLVRCDPVFHKMKLALSLKYTSDNEGKSLLIVKTKGHNDDSEHLRRLLESGVTHSSEIEISKLDFDSLPLDNTVQDAQKIVINDSYDANNFNGQSMNVFLFEFKDHIYSYALSVKLWINKLETAESPKKVSVKTPTSNALQLSDYRAAFSFVLDDGPEFRAILNKYEQSIPNVQKNTIQLIDELKTMETNLKRLVASKRKVVEIIDGLTNQNSVLATFKIKDELRSKLNKIFTPFESQLSFFLEQVCEKRLLNKIKSISTFEDEKNELNSLKKNFEHDSKEFYNWLKKYLSNEKGRPESKLLLKRKKFELSKFDYLNYLNNFSNNQYINEFYENLFKFLSIDLANIPKDLSKVGLTDYHNIYLNVLLKFNSEKYQLRQMIESCSSNDDLTNVIRYNSLTVDSASNDDIKVTSDNLDLIFSPVSPSLTTTTTVSMNPDSPSEDSAEKSGILYALGGKGKQGWHKEWVVVKNGELKEYSDWRTGNAPINTPIQIALSNVKPTTHDKRQYCFEIFTSSGNRYIFQAINEQERDQWIKVLDNARLSVNTDKLKENLSPKEHSKLSKKLNLKLDKPKPIESGAAPSKSPISVVSSAVIPNDYYKAVRYVPDSDNNICADCGSLESVEWVSINFLVVLCINCSSCHRSMGSHISRVKSLKMDNFNRETEVLLTYINNHLHNKYLQSTHKTPSFADYEERLEFIQNKYIDKKYAQSVDGINDLLFKSVRAISVEDTIKCVLLGADVNLKVSLGDKGNKILLFEYSLRKYLTVETDSSPTKIFVISEFLVLNGCKINSVNRDLELSEEAFDFWSSKYSKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAR3</accession>
    <name>G3BAR3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAR3"/>
    <dbReference type="HOGENOM" id="CLU_2333430_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="98" mass="11246" checksum="535501545061122E" modified="2011-11-16" version="1">MVSDAETIKAKISELAETELQTKQLVTKINKLTSDLDRKQEDISSLNKDLDWYKSKFEVLKKEVGDEERKKVSEDKISNKNSDQTDKEYGTLESYVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAW9</accession>
    <name>G3BAW9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114936</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAW9"/>
    <dbReference type="GeneID" id="18247643"/>
    <dbReference type="KEGG" id="cten:18247643"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019699_3_1_1"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47152" checksum="66B3E9096ECB6ECD" modified="2011-11-16" version="1">MDDALLTTVSSVCGYLSFTIWLFAQLPQIIENHLNQSVAGVNVLFLSSWVAGDITNLVGCLLTRALPFQTLIATYYCFIDVVLCFQFYYYTRIFPYHKTPHNLLQSPNMLRHPSHQRSPHEVSNLLGSTARKPRRSSILNILSTGLLAKRANAAPISQFVAVSSGLWLSSDAIGKISAWTCTAFYLSARLPQIRTNFKNKSTSGISPYLFIFAMAGNSFYTASLTTDLFLLYRNHDKEVMPTFWDQLPFLMGSGGTVLFDCMILCQCWYYKANNTNRRAPKHHRSQPSVAGGFQKPDWYVNNFVYEDEEHEEPHYQKVIESLAPHHYIVGSASSNANNLSSRPSSIINSFSKSMRSNSSSIHSPVLQTHLIPSIINSYSSVSKKMANDKTPFSPSDFLNDGFHVPIENSSFSLNNAGSYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAY2</accession>
    <name>G3BAY2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate carboxylase</fullName>
            <ecNumber evidence="4 13">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTEDRAFT_108338</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="4 13"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAY2"/>
    <dbReference type="STRING" id="590646.G3BAY2"/>
    <dbReference type="GeneID" id="18246021"/>
    <dbReference type="KEGG" id="cten:18246021"/>
    <dbReference type="eggNOG" id="KOG0369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_0_1_1"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="20">
        <location>
            <begin position="27"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="19">
        <location>
            <begin position="149"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="21">
        <location>
            <begin position="568"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="18">
        <location>
            <begin position="1104"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="16">
        <location>
            <position position="745"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="775"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="777"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="909"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="17">
        <location>
            <position position="745"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="17">
        <location>
            <position position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV61481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1180" mass="129347" checksum="0F559924DD3F8172" modified="2011-11-16" version="1">MSSLVPSVSEEQKINQMRRNSSVMGSSLSKILVANRGEIPIRIFRTAHELSLQTVAIYSPADKLSLHRLKADESYAIGKPGQFSPVQAYLQIDEIINIAKLHNVNMIHPGYGFLSENSEFARKVEEAGIVWIGPSWKTIDEVGDKVSARTLAIKNDVPVVPGTPGPIESVEDATKFVEKYGYPVIIKAAFGGGGRGMRVVREGDSVEDAFNRAVSEAKTAFGNGTCFIERFLDKPKHIEVQLLGDNYGNVIHLFERDCSVQRRHQKVVEIAPAKNLPREVRDAILTDAVKLAKSVNYRNAGTAEFLVDEQNRHYFIEINPRIQVEHTITEEITGVDLVAAQIQIAAGASLSQLGLLQDKITTRGFAIQCRITTEDPTKNFQPDTGKIEVYRSAGGNGVRLDGGNGFAGSIISPHYDSMLVKCSCSGSTFEISRRKMLRALIEFRIRGVKTNIPFLLALLTNEVFIKGDCWTTFIDDTPSLFQMITSQNRATKLLNYLGDLTVNGSSIAGQVGLPKLDTEALIPDLTDPSTGVVIDLHNQVVPPKGWRDVLLKEGPEGFSKKVRNFDGTLIMDTTWRDAHQSLLATRVRTIDLLNIAPTTAHALSGAFALECWGGATFDVAMRFLYEDPWQRLRKLRKLVPNIPFQMLLRGANGVAYSSLPDNAIDQFVKEAKENGVDIFRVFDALNDLDQLKVGIDAVRKAGGVIEATVCYSGDMLQIGKKYNLEYYVDMVDKIVEMGTHILGIKDMAGTLKPKAATLLISAIRNKYPHLPIHVHTHDSAGTGVASMVACAKAGADVVDACSNSMSGMTSQPSINAILASFEGDIESGLQTSMVTQLDHYWSQMRLLYACFEADLKGPDPEVYQHEIPGGQLTNLIFQASQLGLGARWLQTKEAYKVANHLLGDIVKVTPTSKVVGDLAQFMVSNNLTEEDVTKLAGELDFPDSVLDFMEGLMGTPYGGFPEPLRSNVLGSKRIKLDGRPGLYLKPIDFAKVKEELSSKYGANITESDIASYIMYPKVFEAFKKQLEKFGDLSVLPTRYFLKPCVIGESIEVEIEQGKTLIIKLLAVGEISQQSGTREVFFELNGEMRSVTIEDKTASVETKTRPKASQPNDVGAPMAGVVVEIRCKTGQEVKKGDPVAVLSAMKMEMVISAPVSGKIGEVLIKEGDSVDAADMITNILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB76</accession>
    <name>G3BB76_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport protein particle component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94397</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687676.1">
        <property type="nucleotide sequence ID" value="XM_006687613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB76"/>
    <dbReference type="STRING" id="590646.G3BB76"/>
    <dbReference type="GeneID" id="18250391"/>
    <dbReference type="KEGG" id="cten:18250391"/>
    <dbReference type="eggNOG" id="KOG3316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076409_0_1_1"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="171" mass="19619" checksum="9E26A23089782CE6" modified="2011-11-16" version="1">MESPQINNTLFKLLIMEMIPTIIEVSRSHGLSTDQVNLKIELLGYKLGIKLNELLLFKLADQFSKNNEDLETVLDIMKFICKDFWKILFKKQISNLRTNHRGTFVLVDSNFKPIENFDVSRPDAPVMISHYLSYVNGVMKGTLKSFGINSVITNEINFPSVTFNIETDNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBL1</accession>
    <name>G3BBL1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glia maturation factor beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115032</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688734.1">
        <property type="nucleotide sequence ID" value="XM_006688671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBL1"/>
    <dbReference type="STRING" id="590646.G3BBL1"/>
    <dbReference type="GeneID" id="18247682"/>
    <dbReference type="KEGG" id="cten:18247682"/>
    <dbReference type="eggNOG" id="KOG1736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087056_0_0_1"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="138" mass="15577" checksum="C27EB36C48B0B192" modified="2011-11-16" version="1">MSTNLYTFASPTLSGIQKFRFSSARAPGMQAIIYIIDKSSYEVKREDEDQVITSIEELEEELPPNAPRFVILSYPYKTRDGRSVSPLVMLYWKPATCGQQSKMLYAGALELFRDKAGVSKLVSIEDEEELGSIQDLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCE5</accession>
    <name>G3BCE5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">25S rRNA (Uridine(2843)-N(3))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116882</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690483.1">
        <property type="nucleotide sequence ID" value="XM_006690420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCE5"/>
    <dbReference type="STRING" id="590646.G3BCE5"/>
    <dbReference type="GeneID" id="18248486"/>
    <dbReference type="KEGG" id="cten:18248486"/>
    <dbReference type="eggNOG" id="ENOG502QR34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028833_0_0_1"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34851" checksum="7343D7555E15EEF3" modified="2011-11-16" version="1">MSSRSKRSGRSSENDSIPFEGEHSLGALAIVDLFSQSFQRILDSPDLPEFIQVVKGSLYERQFLEAFDDDNKRFAYAARWTPARSLAYASLFSSLEPVKGLFEDPDSTTSVLCVGGGAGGELVGLASVFCRLKEHNSTSTSNLVVKIVDIADWSAIVTNVTKYMQQNWLYKPEKLTTQFIHKDILGNGFSAYGDLDLITLMFTTNELFSEKRAETIRFLQTLNRSCKQGAHLLIAESAGSYSHITVGTKKFPVQFIIDTVLLGKQGEDTGAWDLVDQSDSCWYRIDEKEVDYPMKLENMRFFYRLYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCE8</accession>
    <name>G3BCE8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF726-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_128475</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCE8"/>
    <dbReference type="GeneID" id="18249308"/>
    <dbReference type="KEGG" id="cten:18249308"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001695_2_2_1"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="734"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="799" mass="88638" checksum="E729C3F6D572F34B" modified="2011-11-16" version="1">MATWKTMKTVTEQDYYDEKGNLEFSSGRDHDRFDPKNVNGGYTRIDTAEQVAKYAEMDKKTDFLFVTKDTDKQEVAKYRHEDNNEDSDDDILYDEVETMETADALQSTREMLNEGQKFSYVGIVKLIMVDMAAELAGIKQSTTSKVARQLSASQKNFANWSMYISGKVYSHLNVNEDEQKMIENLSIHGVNVSDLTSSLVKEDDRKPGPLSLDWVLVCDLFLLLLSDGYYDSRSRALLMRFANELAIEKIEVFQFERRLLNSLELETKDKSLEDKEDKLNDKQIIQKYIKRNKGRRMAYIGLATVGGTLAIGLSAGLLAPVIGAGLAAGLTTVGIGGTSGFLAGVGGTTIITTGGVMLGAKVGSKAGMRRAGDVETFELKPLHNNKRSNLIITVSGWMTGKSDDVRLPFSTVDPVMGDLFSVLWEPEMLKSMGQTISILASEALTSSIQQILGATILTSLMAAIQIPVALSKLSYLVDNPWNVSLDRAWKAGKILADTLVSGNLGVRPMTLVGFSLGSRVIYSCLVELAQKGCFGLVENVIILGTPITINKDQLGLARSVVSGKFINGYSRKDWVLGYLFRATGGGLASVAGIAPINDSYGIENIDVTEFVEGHMAYRKAIPKILQELQWEVLDEEFAEIEEPDNEEGERQRQLIHEFDEARAKMKKEIEDEQKEQTEKKGWKKFFSRRQNNWWSDIGESSDTTGEEYIEQENPTPIFDVGSLLKEAKEIEHLSIPDKSQLPQEVPITKPVSESKLESKPEQKPVLTSISETVAQKSTQLKHKASDMLSKPSESSLDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCR0</accession>
    <name>G3BCR0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_116916</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCR0"/>
    <dbReference type="STRING" id="590646.G3BCR0"/>
    <dbReference type="GeneID" id="18248506"/>
    <dbReference type="KEGG" id="cten:18248506"/>
    <dbReference type="eggNOG" id="KOG3403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_0_1_1"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="152" mass="17165" checksum="D8F08DB076D0BD77" modified="2011-11-16" version="1">MGKSGKGKGGKNRRRGKNDNSGQKRELIYKEESQEYAQITKMLGNGRLEVSCFDGIKRMGHIRGKLRKKVWMGQGDIILVCLREFQDETCDVVHKYNSDEARTLKNVGELPENAKINETDTFGGDEDEDVNFEFGAEDSEEEGADELDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCW3</accession>
    <name>G3BCW3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_99716</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCW3"/>
    <dbReference type="STRING" id="590646.G3BCW3"/>
    <dbReference type="GeneID" id="18250875"/>
    <dbReference type="KEGG" id="cten:18250875"/>
    <dbReference type="eggNOG" id="ENOG502RNK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054606_2_0_1"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="292" mass="33895" checksum="63A253B78F831D99" modified="2011-11-16" version="1">MSKSVGFQWGVKSNVNKPAVNSKHLHKTGVKKRRYDDEKPKVNTNTITKRTKFPIIKGERLPINRLIETLNRSSINLLLTDLVRIHPEICHTIYDLQPKVEVEDAMTILNTRVEDIHHNLPYKGDLENDYSYLRVKPYLNEFLNCLSDYILNYLPPVETNLIQSLQFIDYATNIIMKLPSFRNNEYKYIKLKCYEQMSNTWLIVLNNLIDESEDESEVQESLFNLIKVINDLDLKEKLSTYNHISVNKFDKVLEFINEKSALFNNLNNTSSSLGDLITVDYSNYSLAAPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD27</accession>
    <name>G3BD27_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_137368</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690117.1">
        <property type="nucleotide sequence ID" value="XM_006690054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD27"/>
    <dbReference type="STRING" id="590646.G3BD27"/>
    <dbReference type="GeneID" id="18250061"/>
    <dbReference type="KEGG" id="cten:18250061"/>
    <dbReference type="eggNOG" id="KOG3186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1142929_0_0_1"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="203" mass="24121" checksum="C154D8712D91D9A7" modified="2011-11-16" version="1">MELELNVGNVLKLVKEILVGWINSILYYHKVYPEYIFEPFRSLNMVVYRSRSKMLNEYIDDFINRFSKLLITSNQISELTLLLFNKDKIYYRYCIRFDEFIKLSAKISEDESRSAAIDIDGFTWDEIYKQANAFLFHHLQHLKSVMALMELEFKLLITSSLNLNQDENWVYNSKPSHLTNLKALEEVSVGFLNFNAYVEYHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD77</accession>
    <name>G3BD77_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_111541</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD77"/>
    <dbReference type="STRING" id="590646.G3BD77"/>
    <dbReference type="GeneID" id="18246290"/>
    <dbReference type="KEGG" id="cten:18246290"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="489" mass="54012" checksum="97CA7370619DF2BC" modified="2011-11-16" version="1">MWELSRRKLFTENDQYDSSEMLLFTIASSMIWIMVPGLAFLYSGLARRKSALSMIWIVLVSSFIGLFQWYFWGYSLAFSASSNNFIGNLQLFGFKSIVGENDPEATYASLAFSIFQMQFMLVTLAILAGACIGERGRFLPTCVFLFFWATVVYCPVVYWIWGGGWASSWRGGALDYAGGGPVEILSGVSAFVYSAVLGRRNQDLMINYRPHNISTVFLGTALLYVGWLFFNGFSCANASVKVPYSMMNTHLTAAFGAISWCLLDFRLEKKWSMMGICSGTISGLVAATPASGMIPLWASVILGVVSGVVCNLSTQIKYVLRVDDSLDVLAEHGIAGIVGLLFNGIFGSSTVIGYDGVTDHAGGWIDHNWKQLYVQIVYILATAAYSGGMTFVLCFTINKIPGLHLRVDYHGEEVGIDEDQIGEFAYDYVEVRRDFLSWSDPNGSGERSVVEEVGQESQQQADKEADVYEAKPESSESVDNSTNNELKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDB8</accession>
    <name>G3BDB8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_116981</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690525.1">
        <property type="nucleotide sequence ID" value="XM_006690462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDB8"/>
    <dbReference type="STRING" id="590646.G3BDB8"/>
    <dbReference type="MEROPS" id="C12.009"/>
    <dbReference type="GeneID" id="18248529"/>
    <dbReference type="KEGG" id="cten:18248529"/>
    <dbReference type="eggNOG" id="KOG2778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018316_1_0_1"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="308" mass="35314" checksum="B85583D7D8A1C83A" modified="2011-11-16" version="1">MASSGWNTIDSDAGVFTRLVEKLNVKDVQFEDLYSIDSDSLRALSPIYGVIFLFKYSAIDRQYALDNNAPLAGEYDQDFQQYDIFFANQTIQNACATQAVLNILLNQIHVDVGEDLANFKSFVTGFDPLMAGETISNSDLIRSVHNSFSTPSILVDEDPSKPPPDSDHKNDGLFHFVGYVNVNGYIYELDGLKDFPIRHCSCSSQDEFIDKIPSVLMERISKYKDELRFSTLVITNNKLKQYKEIGDSFMVESEINKRDLWDREIELRKHDYTNLFVKIVKDISSKSSDQDWHVLLDKARQKSKRRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDC1</accession>
    <name>G3BDC1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_132558</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDC1"/>
    <dbReference type="STRING" id="590646.G3BDC1"/>
    <dbReference type="GeneID" id="18249631"/>
    <dbReference type="KEGG" id="cten:18249631"/>
    <dbReference type="eggNOG" id="ENOG502S19D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074138_2_0_1"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="247" mass="27648" checksum="158998C77F1DE4A4" modified="2011-11-16" version="1">MSSIIATNIPSTVTVEKLQEFFSFCGDVKSINPLGSGKYEVNFKSEKALSTALLLNDAELEGSSIKVEENKLPTYEEVPDKKPEDVGTSDEKKSFTATGDHNYDDIEQEEKPKYAIMAQLLSQGYGISDQMIEKSISFDKEHGYSTRFKGFVKSLDEKYIHLQNPESKSSKLLGDLVGQGKVVYGKFNKYFEQLAENPYGAKVHDFYKNLAGDVKDVHLEAKRLNQLKKEEDAKSGVDHVSAIIDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDH9</accession>
    <name>G3BDH9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116353</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDH9"/>
    <dbReference type="STRING" id="590646.G3BDH9"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="399"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="457" mass="51270" checksum="39950C5E176D5340" modified="2011-11-16" version="1">MSFKGLKKTIVRAPQNFRQKLNMGEITHDPVYADAERRFKELELETKKLSDESKRYFNAVNGMLDYQVDFSKAIEEIYKPISGKLSDPNAAQPEDNPEGIKASESYREVVLELKETLKPDLQLIETRIVAPAQELLKVIQCIRKMATKRDHKQVDLDRRNRTYKKYQDKKERTAKDEEKMYNAEAEIQIAQQEYDYYNDMLKTELPILFQMQSDFIRPLFVSFYYMQLNIFYTLYNRMEELKIPYFDLTTDIVEAYHFKKGGVEEQTDAIGITHFKVGHAKAKLEATKRRFAAQGAEGTPAYGAYGAGETNTLPPYSPGAAPVQQYGDYKNPNGPGYVAPGQPQYGQPQYGQPQSPQYQTPPSSAPAYGAGVAAPAYGGYGSPSPISPTPATPVSAIATGSQTCTALYEYTAQAQGDLTFPAGAVIEIVERTADVNGWWTGRYNGQTGVFPGNYVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDR3</accession>
    <name>G3BDR3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_95813</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDR3"/>
    <dbReference type="eggNOG" id="ENOG502TF7M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020810_0_0_1"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="660" mass="74802" checksum="3A00E655EC60FBD1" modified="2011-11-16" version="1">MDLQHEPKEEDSQEQQQEVDQETTLQDASVLIDSQLAAGRSPADIVKRFRTSRTARADYTPELLVSVAATSDGKCVVNCHRCYRLKKKCSREFPQCQYCLKTNHDCFYVDRKRAKKNFSSEYFPSTSTTTKVGGEDGGEGDGESEAMTDSTQMAPESSAASPVKSSSLNPTSCTRCSRLKRRCSRSLPQCRHCVRTSNECVYDKNKKYRVLSFDQLVQAAAAATARASETSQSGANSHEASDEFTQIDPHVPSASASVSTNEGTSTHPFKKSRSRSEEELINIKSFGADASLPSTFIDNFFYNYEYTYPVVHKTEMEAELRQIDFASEALVNLKMYVVLSIGCLVYDSINRTDQFAEYFNEHLLESVADSVENPNPDVANVALAALVALYYVNRKRFNQSWNMVGVLTRLMIKFDLYRRKGVYADIFWTVYNLDKDLSLILDKPSQLPVDSIIEAPVPQDDLTRKFNELYRLENKINNYKLSLKTSRGEDTTVRIISNEIENWRVSVSSLLHVHFFDSTNLQEFTTLVNLNYFYLCIELDELADVKSSQFMLQFLSQYFALTLNEKQKSMVGLSINNLMYYQKLLKVIRYNALNVISDRKSQGYVENLQIVLNLLKYMSSYCDVSVLVSLCQHLSDVRDSDEARATVNTIVAKTTPIPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE87</accession>
    <name>G3BE87_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116538</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689702.1">
        <property type="nucleotide sequence ID" value="XM_006689639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE87"/>
    <dbReference type="GeneID" id="18248351"/>
    <dbReference type="KEGG" id="cten:18248351"/>
    <dbReference type="eggNOG" id="ENOG502RQEZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2145556_0_0_1"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="112" mass="13028" checksum="CA2E236B06210913" modified="2011-11-16" version="1">MFEDYCSSHGKQCIPGSIYCSEECRIQDWEENFHFESDSEPEDAQPERPAQYSLMYECPVCQSTTACVHYNLHLNNNIILDTLKDIEVSSNMDSNYIKSNYYKWLINSAAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEB2</accession>
    <name>G3BEB2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_132248</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689722.1">
        <property type="nucleotide sequence ID" value="XM_006689659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEB2"/>
    <dbReference type="STRING" id="590646.G3BEB2"/>
    <dbReference type="GeneID" id="18249607"/>
    <dbReference type="KEGG" id="cten:18249607"/>
    <dbReference type="eggNOG" id="KOG3421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082438_3_1_1"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="133" mass="14779" checksum="BC4094BE22C4AB42" modified="2011-11-16" version="1">MSSYSTVKAANWRYVELGRVVLVNNKDLATIVEIIDQRRVLVDGPNFQRQAISLGRVVLTPLILSNLPRGARSGTVAKKWASADIESKWAASSWAKKLAAKQKRAGLSDFERFQVLVLKKQNRFAVKKAVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEJ9</accession>
    <name>G3BEJ9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_116641</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573</strain>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEJ9"/>
    <dbReference type="STRING" id="590646.G3BEJ9"/>
    <dbReference type="GeneID" id="18248382"/>
    <dbReference type="KEGG" id="cten:18248382"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043308_0_1_1"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="126"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="225"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV61195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="303" mass="34646" checksum="8BABBE4002BBBF92" modified="2011-11-16" version="1">MNRPARVQVDPSSLPDDRPPQTGNVFNVWYLKWSGGDGSKNYEKSRFRVDITRDSGRTKANKSLTSTICLYFGRGCCYRGKSCDFLHRLPCETDYFPPTQDCFGRDKTFAHRDDMDGVGALNKINDTIYVSGLHPGDHTESVLSRHFSEFGSIAKIKVLYNKSCAFITFKHEFEAQFAKEAMQCQSLDDNEVLMIRWANDDPDPTSQVEKKRKLEEITVNTVKNLLNRQQQEHEESETEDPEIVEPEEPASPEHEPGQKLLEHSIFNQNSLSVLSKLKKRKMDMKPKDPPKTLDLSGYSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEQ4</accession>
    <name>G3BEQ4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_111300</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689163.1">
        <property type="nucleotide sequence ID" value="XM_006689100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEQ4"/>
    <dbReference type="STRING" id="590646.G3BEQ4"/>
    <dbReference type="GeneID" id="18246264"/>
    <dbReference type="KEGG" id="cten:18246264"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042569_3_0_1"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV59949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="348" mass="39306" checksum="496B730A91722FA6" modified="2011-11-16" version="1">MAFNAFVSSKHSVAGHAGTLVATGIFSKKTTSQEFEFYQNLQLEDHARADPDHYVGDLLSDWVPKFYGSLTENSLESSLDAVSSQLYKMQLSDHTLPESVKLTDKKYIVLSNLYDKFVNPSILDIKLGSVLTDESASPEKVERLKKVSESTTSSSLHFRFCGMKVLHPSSEMPDLSVFGDISDTVTVERDEDVEYLRFDKYFGRNLDGSTVKNALKIFIFHGVKDKAVGLHYLQQFWKRLQLLYNCLLNYEVRIVSGSLLFILENSDKILDGLDLEEHDPLILEDEDDSDSDDEEEENIAPPKQISSLHLIDFAHSKFVKGQGIDDNIMEGIENLITIFEQLIEEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEV7</accession>
    <name>G3BEV7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease V, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Defects in morphology protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_111997</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEV7"/>
    <dbReference type="STRING" id="590646.G3BEV7"/>
    <dbReference type="GeneID" id="18246338"/>
    <dbReference type="KEGG" id="cten:18246338"/>
    <dbReference type="eggNOG" id="ENOG502QR0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019985_0_0_1"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="518" mass="60360" checksum="198E8381F4471C46" modified="2011-11-16" version="1">MSRATNDLISKFIILPKAVNITNPKLLRLFETFKLNYDEFLPTKKPSFIDKNPFEFHSSYNGNQSYVNNPRLSVTKLLTESWCELRDYYEVYSGSVMEPSSEAQSLGSKYHEELEMESFEIISIGEFQKVLSEIFPVEQCEPGFRGIKDPGLAEIAFEPENMLAYDWAESIMFKLYSLMLNSETRELLVHDYLDLTHQKLGLSPDSVLISGIIDHLKLVNVKDPQDFSMFEEIKAFLDLKFDNGIVDLDALFLGLENILSSYNEIYKLQITDVKTRRFNKIPNQDSVLKSAYLQVSYYKEFFERLSQDSKYTYESLCTNAMIRHHDLDKPLHPIILFSLLRKYPELFLNDFKSIAKGSSIGHVPYSSEFKEFDGYDFTDILTPEILKSLEQIDDFNYKSILSTDILRKWERPLTLRYFAARSSQFFNLFKPFNSDLISIEYHNVRTKFNFKTIKYKFNKDDLENSVVSSSNFWNGTSSPRVVDDLSKCKYCDFNTKCSVPNQDMKYFGHKLSNFLNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEY3</accession>
    <name>G3BEY3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_95433</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEY3"/>
    <dbReference type="STRING" id="590646.G3BEY3"/>
    <dbReference type="GeneID" id="18250500"/>
    <dbReference type="KEGG" id="cten:18250500"/>
    <dbReference type="eggNOG" id="ENOG502S5DP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119118_0_0_1"/>
    <dbReference type="OrthoDB" id="69550at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="9">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV59964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="180" mass="20045" checksum="3FEBAC0D2B617D35" modified="2011-11-16" version="1">MSTSSTIEHARKGPSKSRRRKKRRTEDISSSSSSSSSEDEEEIQPNSDSPNEVKTPQSDLKPRADPDIAALDELQTAIQARLKQVPFTDQNAKASRTDPTIQAQEDLVTKHSKERDELDKKFLQLMAQRFGDDLDEARKKPDFNADSLVIMAQTLQSGSNIFDSDEIHELMHEGSSSAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF51</accession>
    <name>G3BF51_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">PIN domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_132346</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF51"/>
    <dbReference type="STRING" id="590646.G3BF51"/>
    <dbReference type="GeneID" id="18249614"/>
    <dbReference type="KEGG" id="cten:18249614"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003018_0_0_1"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="706"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="445"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="109872" checksum="85E7CE089111D264" modified="2011-11-16" version="1">MGVNSLWDILGPTARPVRLEALTRKRLAVDASIWIYQFLKAVRDSEGNTLHSSHIVGFFRRICKLLYFGIQPVFIFDGGAPALKRDTIKKRKERRDGKREDASETAHRLLAIHAQRRVQQPKENNDDTVYLEDLPGQHPNHIQHSPSRTGKRFVPSDEYHLPELKKIKIRESDERLLPDEEYRELASESFDIVDGIDINSVNPNSEEFAELPMSTQYMILSHLRLKSRLRMGFSKEQLENIFTDSMDFSKFQIQQVQKRNFYTQRLMDASGMGEDGNATRRIAGEKDRKYALIRTDDGWALSLGQEDDHQVVEKAPVELNPQFPEIINISDKSEDDIEVGDEDDDDDDDFEDVSIGEAPVENAEDQELNRAVIESIYEQYEDKPVSKATDEFSQDELKLAIEKSKKELSVLVQREEAMITNQTVEPFDFNFGDSLLFSSNQSAEPVNAYPKSHKPQKEVPETIVEEEEPESYYDRLGRKEKELEHLDQLEALMESEEETDKKDTAKQNSVPEWFNEKLEANSVYQNFQAEREDSVEKDEDVGLIPWDKAKEMLDNESEDEDPHEVEEISHTNLVDSVEDESIVISEANTQGIEDPVDVPEVEEKDTEVDVKVEPVEETSSKTSRKDGVLDYVFVDDEDELADRQLLQEEKDHDKLKRDIAAHHEPLLNITTSITEEQLLQERLLKQKRDSEEVTQAMINDVQELLRRFGIPFLTAPMEAEAQCVELLKLGLVDGIVTDDSDTFLFGGDRVYKNMFNQKQFVECYLSEDVSGKLGLSQEKLIELGLLLGSDYTEGVKGIGPVLAMEILAEFGSLHQFKEWFDDCNLRAKNDSSSSLKKNLLNRIKNSKLFLPPSFPDSVVFDAYIHPEVDHSKDPIKWGVPDLDSIRSFLMYNVGWSQGRVDEVMVPLIRDLNRKLREGTQSTIGEFFSTSYIQSKREVQIGKRMKAAATKLNKKAAKDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFS8</accession>
    <name>G3BFS8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RCC1/BLIP-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_109908</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFS8"/>
    <dbReference type="STRING" id="590646.G3BFS8"/>
    <dbReference type="GeneID" id="18246150"/>
    <dbReference type="KEGG" id="cten:18246150"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028610_0_0_1"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="408"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="476"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="635" mass="72159" checksum="8E3680A164CFE92F" modified="2011-11-16" version="1">MNINMLGVRMYAKDSKYRNIDEFNKFKTEFKFGDGVQEHVSEGSNTKEIHSRIAEQQEEEKQQSINELLESDPRLSQLEYGSPEYKEMLFRISEEFRRKERKNRQRYESRERFKAVGYGIAAIVGIASLHQFIFHYQWYKSVFNKSSYDVDESQVKTTVTNVKKLGYMQGKLQQMLDASFLGSVLNSEQNSGLYVFGSHNGSKLPIRIEFFDHMLLKDVQISGDFLVAVADNGKVYQYTKTMKQPELVRLPSKIESCKISQGFVYFLTVSGQVVYAPRPDKEVQFISPQSRNWVGIKRDDGYSSLDLSDFNRGEKVNEMSAGDNHMLLLTNQGRLFNLKTAEGPNYGQFGTPAFAPVKNSEVPVNEVFPLTSLNNELVSDGDARFLRPRTFTHIASGSFHNLASDSNGDIWCWGKNSHGQCGMNVTHKSDVQPIPQKVFSFTDFKKILKTEVLRVEKLDCSEETSYVMLKNKNETDVLLSFGNGIKGQLGISRYLHLSNVPLVVKTLNLKEFNETTNKVQDIGIKEISSGLNHTIVKLDNVGSKKDIMIFGDNEFGQFGNGKLIRSSKPVPIPELIEPHDIVDIENMETMKSLTKRVFDPDNRLSLKESLKINGTTVEQVIKATGNSSVIYYKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AVY6</accession>
    <name>G3AVY6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_91487</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996508">
        <property type="protein sequence ID" value="EGV66898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AVY6"/>
    <dbReference type="GeneID" id="18250074"/>
    <dbReference type="KEGG" id="cten:18250074"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_14_1"/>
    <dbReference type="OrthoDB" id="4090645at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="144"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="414" mass="46454" checksum="8251BE10D3BC8B9F" modified="2011-11-16" version="1" fragment="single">MSNDPLKLQRRSLTPFLSKRVPPIPSEDERKVCPEKKSNWISQLFFLWLNPILKVGYKRTLQVDDMYLLADTTKVEYLATQFNSYFEHYLQIAQEQHIANKCTERGETVPTSSVDPDDDLADFKVPRKMFLWCLFLTCKWQYTFAAVSVTVAGLLNCLTPLVTKELIKYVEMKALGLEHHTGRGVGLAIGVPIMLISGSLCISQGFYRGMLTGAQLKGVLTKAILEKSFRLNPQSRHQFPASKITSMMSTDTARIDFAAGFQPFLISFPSSLICILVVLIVNLGASALMGFAVLVVFLVGIGGVSKKMFAVRKSATVFTDQRVNYIKEVLNNLKIIKFYSWEEAYFKIISDVRTKEMDRLYVMQGMRNIVITFSSTLSTFASIAAFLVLYSTGSSKSNPANIFSSISLFNVFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AVY9</accession>
    <name>G3AVY9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_100918</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AVY9"/>
    <dbReference type="STRING" id="590646.G3AVY9"/>
    <dbReference type="GeneID" id="18245420"/>
    <dbReference type="KEGG" id="cten:18245420"/>
    <dbReference type="eggNOG" id="KOG1615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036368_4_0_1"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="306" mass="33604" checksum="B66066365BEDB105" modified="2011-11-16" version="1">MSDFTHVITIIAHGNDLSAETLATIKRILVDQATLPLGVSKSLSPRAIDFPTTISNDVDITAFLKRTFNKDTGYDVILQPVANRKDKKLFIFDMDSTLIYQEVIELIAAYADIEQEVADITERAMNGEIDFTESLKERVLLLKGINSTTIWEELKHKIKITNGALELCKALKKSGCIMGVCSGGFIQLAEYVKERLGLDYAYANVLGIDENNILDGTVVGETVNAEMKAKLLLEIASKHNIDPQTAVAVGDGANDLKMMEVAGFGVAWNAKPKVQQLAPSCLNTKSLADILYIMGYTDTEINKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWB8</accession>
    <name>G3AWB8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_128906</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWB8"/>
    <dbReference type="STRING" id="590646.G3AWB8"/>
    <dbReference type="eggNOG" id="KOG0732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000536_6_0_1"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19517">
        <property type="entry name" value="RecA-like_Yta7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="959"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1052"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1097"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1069"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV66505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1200" mass="134668" checksum="2D14AC1115D523B9" modified="2011-11-16" version="1">MSRRSRNTKPSISDDEDDGFNSQESDKDELEGSDSIPSDNDKDQDDYLEDDEDNEDDDEIRTSRRRKASRARALNDEFTRKLTEKRFIASDEDVSDDYEYGQEPVKKKKRSRSRSVEPVFLPKRGRLRSTRNSEAVGAAEEAEAGAEDGKEESEEEVEDDIKKELAALYDSSPEPELKHKLRERAPVDYAIPPPITNDAQLEAGAPITPSFTKGRRGRPSTNKSEYRNLLFPTAGPFGGSDVISVFGTNIPPGGIPIPGMSATNNNMTAIGQALSDSDSSDDEIAPINGEATITKKQPKDNFLNHTKLIGTSTAKHQNKKKNNLSDTDPLGVDMNIDFSAVGGLDEYINQLKEMVALPLLYPELYQNFAITPPRGVLFHGPPGTGKTLMARALAASFSTSTRKITFFMRKGADCLSKWVGEAERQLRLLFEEAKNQQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDNRGQVIVIGATNRPDAIDPALRRPGRFDREFYFPLPDTNARSQILKIHTKKWSPPLGDEFLGKIADLTKGYGGADLRALCTEAALNSIQRKYPQIYQSNQKLEVVPSKVKVIAKDFMNAMEKIVPSSARSTSSGSAPLPQHLKCLLEPQYNEIILKLNNLLPNSIHLKGEKKKTQLEDALYLDPTIHDEDGGFARQEFLKNLENSRICKPSLLISGESGSGQQYIGAALLNHLEGFQVQSLDIGAIFSDSTRTPESAIIQTFIEARRHQPSVIFIPNIDIWYHIVPPTAKATLSSLLKSLKSNEKILLLGISESSQEALDYEVKLLFASTNETNSVTLHNPDVGQRRQFFGTLKKTLLMKPYEFVNDFENRPKRKLKQLKVVEEVVVVDKDSEKKKLKAQEYQDTKLKNTLKIKLASLMDLFKVRYKRFKKPIIDENLLSHIFYPEILSNPLNVYEVLYEKAADDEHKDMIKELATGKYYHNIDLDIIEERLWNGYYSEPRQFLKDIKMIVSDSIMSGDRERILKANEMLTNAQFGIDDIGTPEFLSACKEMRKRELVKQAQVVADYQKLQEAAQKQQEANGSLQNGNAVNGEPEEISVETQDDQEPVVATDVKIVADVEQETAIEPRKEQTAVAKPPIPGSDSESEAEDSPIDISRQLVLGGDHEEFFSNRIIEITSNCNIERLEIVMARLMDIIWTDRNQWDKTQTIKNLYNAADSIEAEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXB6</accession>
    <name>G3AXB6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_128774</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXB6"/>
    <dbReference type="STRING" id="590646.G3AXB6"/>
    <dbReference type="GeneID" id="18249335"/>
    <dbReference type="KEGG" id="cten:18249335"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001721">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="274"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="543"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="773" mass="84533" checksum="AD3ABA8C91341E9E" modified="2011-11-16" version="1">MSSKSNSKNKKNASTPTPSEAPPRKVKIPKAYVVRPAVNLNPKSTSKVYIHQDIFEALELKNSDIVYICKSESGEPGVLASIHSDADIMDTNVIFVSAGLRSLSGILLGDRVLISKYMKQPQFANRIHIHYLGEAEESSLKKIEKVIDEIGLVAPGLQINGIELGETNVSIRIIDIENPQPLEDSLQDLSFSSKISSQDVSSDTITPYFLFSKGNGSVQIVSTDTIDTTKYPNFHRRTNFDQVGGLSKQISLLQSTIEVPLHNPQLFSEFGISPPRGILLHGPPGTGKTMLLKCVAQNIDAHVLSINGPSIVSKYLGETENAIREIFLEARKYQPSIIFMDEVDSLVPSRTSEDSGETESRVVATLLTMMDGMNDTGRVVVVGATNRPNSIDSALRRPGRFDQEVEIGIPDAEDRFDILSKLVGKMNQAKFDLSEEDIRSVSSKTHGYVGADLSALCRESVMKAINRGLKNGISQSDIKLTVEDMLSSLPDIRPSAMREIFLEMPKVHWSDIGGQHELKRKLVEVVQLPLEAAETFNKLGVSAPKGVLLYGPPGCSKTLTAKALATESGLNFLAVKGPEIFNKYVGESERAIREIFRKARAASPSIIFFDEIDAISGDRESANTSAAQQVLTSLLNEIDGVEELKGVVIVGATNRPTEIDPALLRPGRLDRHIFVGPPDYEARLEILKKCCFKFNLTEDVSLHEMATATEGCSGAEVTLLCQESGLAAIMENNNASSVSKKHFEHALKGISKGITEEMLNYYTEFSQRSGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXY4</accession>
    <name>G3AXY4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112587</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXY4"/>
    <dbReference type="STRING" id="590646.G3AXY4"/>
    <dbReference type="GeneID" id="18246594"/>
    <dbReference type="KEGG" id="cten:18246594"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_4_3_1"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="364" mass="40863" checksum="1B13843CD43896C0" modified="2011-11-16" version="1">MVDNKQLKPEITALLNPVVDQLTRHQITGDKTIALEISHLLMRVISATRWSNPYDLVNTIRQVGVVLQAALPREFICGNIVRRVLSIIRVEIEENLELDPNSESNTMMSSIFSLLSTNNNTVKQESLIQSKKQSSDLRSIIIQGIRDLIDEIINVNEGLENMSADLIHDNEILLTPTPNSSTVLQFLIKARSKRKFTVLVTENYPNEIEQTHKFIKKLADNKIETILIPDTTTFAMMSRVGKVIVGSNTVFANGGCMSNSGVSNVVECAREHKTPVFAVAGLYKLSPLYPFNRNDLIKVGNSGKVLNYSDYELLENVDIITNPLNDYIPPENIDIYITNIGGFAPSFIYRIVLDNYKPEDNNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY05</accession>
    <name>G3AY05_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_101919</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY05"/>
    <dbReference type="STRING" id="590646.G3AY05"/>
    <dbReference type="GeneID" id="18245513"/>
    <dbReference type="KEGG" id="cten:18245513"/>
    <dbReference type="eggNOG" id="KOG4017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053731_0_1_1"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="4">
        <location>
            <begin position="233"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="378" mass="44408" checksum="13B8DD39B7131F84" modified="2011-11-16" version="1">MSFVKGTLSDAQRQRIEANRRRALERLQKKGLRDQTVVSSIDPTIVADSGNSISVDTHNQTTGSTIDLSQKKQKVELTPEQRKRIEQNRKKALEIRENLQKNHRDATDHTIPTLPVPDALVQQEQAKKKSEVIKPMNRKRDYIDYDFSTMKDTHGGFMDDPSGDEDALINQSLEDWKERQKRELIVHDLAPPLDIASAPKCVECESLEIDPNYYSNFKQTRVCRRCAKEKPEKYSLLTKTECKEDYLLTEPELQDINLLPRIEKPNPHGYSRMQLFLRLQVEEFAVKKWGSLENLDKEWERREEMRLKRKDKKYKDKLKEMRRKTRAEEYTTKLRNGKSLNDKHVHDWAQPIPFVKDDMNFVKKRCIDCGIEVEEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY32</accession>
    <name>G3AY32_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112619</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY32"/>
    <dbReference type="STRING" id="590646.G3AY32"/>
    <dbReference type="GeneID" id="18246607"/>
    <dbReference type="KEGG" id="cten:18246607"/>
    <dbReference type="HOGENOM" id="CLU_823858_0_0_1"/>
    <dbReference type="OrthoDB" id="4018477at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="36853" checksum="E421523D3DE7262D" modified="2011-11-16" version="1">MSMVTDRIALSSIDSNSLSLRGNTSKSIPLIPAKKSRSFTTSFSNSRSNSFTTSSLNLLSSTSSVRKPSADSSSDVDIYASKLKFKLKLAVFKLNQQQGSRTKSGSFTFYNSEYLVKSPSNSSTKLISTSKAIHQLSPSIKLSRFLKTSNINTKHLVSKSVSFPVKKTFENSININLTQKSLNSLILSKSFNNNNNNSNNLKLFSIKKDSPFYSNCKIPLTLSEQKAIFSGSKISLPLATRFSEPSSALASSNSLLSFKQDPLPSINKILKTPLKLTSHTSTLTSAYNDDNDQTIDDQSFDDSLKKNNSSSPLRHFATPNSFSVAKSLLQLGSGVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYB4</accession>
    <name>G3AYB4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_118546</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYB4"/>
    <dbReference type="STRING" id="590646.G3AYB4"/>
    <dbReference type="GeneID" id="18248650"/>
    <dbReference type="KEGG" id="cten:18248650"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_20_1"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="4">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="489" mass="55324" checksum="624E59CE51FBF282" modified="2011-11-16" version="1">MRKSNLNLNIFHIMYNNTIPVINDTKVTFNNRSIPTSDAEVRSLLRKLKEPITYFGEDNADRRSRLIKFINEMPHTNFGENFVVDDVTMKSDQEDEDVSEDDEEFYTPGTHELLDARKQILTYSLRQASARIRRLREEHEPDPIKVLKHRRIINGKAAKFEIYGSQLIPNNQRAISTVRYNDDNSKIACGSWDGNIYILDSQLSLVGRSVPGYHLEKVSGLDWNGSKLLTGGNEGSINYWDCSSDPTKPYTPLKTIKAHDSRIAKSLFHPQKSHFISTSFDQTWKLWDFEFGTEILQQEGHSKEVFAASFHPDGSILSTGGLDALVKLWDLRSGRLINNLSGHIQGVYSMDWSSNGYHIATGGGDSAIKIWDLRKINNNLNKSPIELCSIPAHTKLISDLRFYNPSSSSSMKLSEIVTDKNDENPTKLSSSGKLLLSSSYDGKIRLWSADNWIKVGETISTDKVMGCDISQDGAQIVTCHWDKSVKLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYC5</accession>
    <name>G3AYC5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_118566</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYC5"/>
    <dbReference type="HOGENOM" id="CLU_2867458_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="64" mass="7314" checksum="3563B249C28E0071" modified="2011-11-16" version="1">MPDMLATFPLKANHGVNSFRIPYYHPNFGQQILGCNFAVLQEQLCLASFLVVWISCYSFKLVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYL0</accession>
    <name>G3AYL0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112742</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYL0"/>
    <dbReference type="STRING" id="590646.G3AYL0"/>
    <dbReference type="eggNOG" id="ENOG502RC91">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043167_0_0_1"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="53758" checksum="F45FD02B6FADBC66" modified="2011-11-16" version="1">MINSIVIQRPLSVYENFFRCRTANRFYKTFQVASTYSKPLTRDNLAAALRRFLLDYHLFACNVFLEEGGYVMKPIDRVMFDDVFVDRSQDSETFLHKGVITEAAMTWLNHYQFDLYVQKPLFKVVLFDPYTLSVVLDHTLFDGVTASSFHEVFLKILDDLDADAALGCNNNDVLFSKEEDTPHLTHSLPPPIDDYLPSWDLDYSDGDPNYYDKVTPPGLKKFPGRFPNSTNHTLAFKLTNFPPSELRMMLARSKQEGVTLTAYLQYVLVMSFQPVFGDTYYTVNKVAIALRRYFSKDKAPPHYKHYFDDLEYKNMGVSANLGLAQNYPPLKKFSWDDVKKASGNLAAAVKNEKLLNMSVKFRDSYNPLTDNEGFFTGIGGNKSETSKLSNLGFIKIPEYKHGWTISNMIFSQDVSAVTSDFMFNFISTPEGGLNIVTSYYNHSFEDCEVDNFDSFLENFRSNALKYCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYN5</accession>
    <name>G3AYN5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112767</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYN5"/>
    <dbReference type="STRING" id="590646.G3AYN5"/>
    <dbReference type="eggNOG" id="ENOG502S526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1151665_0_0_1"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14710">
        <property type="entry name" value="bZIP_HAC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="254" mass="28700" checksum="1094FED4B5372314" modified="2011-11-16" version="1">MDMDIKTTLPPRKRAKTEEEKEQRRIERILRNRRAAHQSREKKRKYVEYLEGYISRLTSNLDNYHHNQEFLLSKINSSGSDMSSIRSNLKKIDNLVEYQDFKFQPSSTVRRSSIGDYSADLDSNENGADASANNDDVSPDSYNNEEDSFPVPVEKSTQPADDSVVDSSDFSPDEADFNLLINPVDNYLSPVSIDSPANSPIDLSLIDLNYVHNSSNHLGLLDSDQSPMDLEHNSAVPILDFELNGDMGGLFVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYU8</accession>
    <name>G3AYU8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">OLA1</name>
        <name evidence="6" type="ORF">CANTEDRAFT_112811</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYU8"/>
    <dbReference type="STRING" id="590646.G3AYU8"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_1_2_1"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="396" mass="44549" checksum="2BD718AE10D9E195" modified="2011-11-16" version="1">MAPKKKAVQEKPILLGRPGNNLKSGIVGLANVGKSTFFQAITRSPLGNPANYPFATIEPEEARVIVPSPRFEKLCGLYKPKSEVPAFMTIYDIAGLTKGAHAGEGLGNNFLANIRAVDAIFQVVRCFEDSDIIHINDEVNPTADLEIISDELSLKDIEFAQKHLEGIEKITRRGGQSLEVKQKKEEAELVKRIIELLEKRQRIANQTWTAKEVEIINSMFLLTAKPCIYLINLSERDYIRKKNKYLLKIKEWVDTNSPGDMIIPVSVSLEEKLAGMETDDEREAYLKEIQTQSALPKIITTMRQKLDLISFFTGGPDEVREWTIRRWYTAPQAAGTIHTDLERTFILAQVIKYDDLIELGDENAVRAAGKLLQKGKDYFVEDGDVLYIKAADGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYV9</accession>
    <name>G3AYV9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="14">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_112817</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="14"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684516.1">
        <property type="nucleotide sequence ID" value="XM_006684453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYV9"/>
    <dbReference type="STRING" id="590646.G3AYV9"/>
    <dbReference type="GeneID" id="18246691"/>
    <dbReference type="KEGG" id="cten:18246691"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF143">
        <property type="entry name" value="PLASMA MEMBRANE-ASSOCIATED COENZYME Q6 REDUCTASE PGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="62"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV65942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="304" mass="34647" checksum="5766BB7F55CCD6F6" modified="2011-11-16" version="1">MEDKRDLLKQPLHGIYIPIALMIVGTLMLDVSYMPYTIAFIVIMCSINFYSAWSRRCSIDPVKWTELEMIDRTVISKNSAIYRFQLKHQDEVLDIPTGHHLACVFMVDGKDEVRYYSPISNKYDAGFFDILVKSYPNGKVSSRFPNLREGQTVKFRGPVGRLEYKTNMAKEIGLIAGGSGITPILQVITEVITTPADTTKISLIYANNTLNDILLRDEIDELSKNYPNFKVHYTLTEPPANWEGSTGFVSKEMITKYLPKPSEENRLFICGPPEMKKSLIEISQELGWDKTSMKSDPNDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ29</accession>
    <name>G3AZ29_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIRA-interacting protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112864</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ29"/>
    <dbReference type="STRING" id="590646.G3AZ29"/>
    <dbReference type="GeneID" id="18246710"/>
    <dbReference type="KEGG" id="cten:18246710"/>
    <dbReference type="eggNOG" id="KOG2358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_0_2_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000004">
        <property type="entry name" value="HIRA-interacting protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="250" mass="28143" checksum="103D851CB20F479E" modified="2011-11-16" version="1">MLRGIIPHTRPARVLGARWLSFKTYPTPNPDALKFVSVEKEILPLENKTFEFTSSLQAIHSPLALKLFKLPGVKSVMLGPDFLTVNKQDHVNWSNLRPDVTELMDKFLTDGKDPVITRELIDETQRQMSADEADDSEVVSMIKELIETRIRPAIQDDGGDIEYKGFDEETGTVFLKLQGACKSCSSSEDTLKHGMESMLKHYIEEVENIEQILDPEEEIALKEFDRLEEQIKARKVARSSGSSSVAPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZE5</accession>
    <name>G3AZE5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_102387</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684650.1">
        <property type="nucleotide sequence ID" value="XM_006684587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZE5"/>
    <dbReference type="GeneID" id="18245547"/>
    <dbReference type="KEGG" id="cten:18245547"/>
    <dbReference type="eggNOG" id="ENOG502RQDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198478_0_0_1"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="77" mass="8956" checksum="917473C617F9F33A" modified="2011-11-16" version="1">MSIPEHPQNLGFLEAQQGYKDIQIKTHDYKDKPTPLNAKQNKASEFISNQTDKDHQKKYAKQVGRKIFDVLIRQVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZM5</accession>
    <name>G3AZM5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_101275</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684195.1">
        <property type="nucleotide sequence ID" value="XM_006684132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZM5"/>
    <dbReference type="STRING" id="590646.G3AZM5"/>
    <dbReference type="GeneID" id="18245452"/>
    <dbReference type="KEGG" id="cten:18245452"/>
    <dbReference type="eggNOG" id="KOG3715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035854_1_0_1"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="1">
        <location>
            <begin position="48"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="230" mass="25719" checksum="76295801009BF982" modified="2011-11-16" version="1">MSNYMVCLAHFCELHGPSSIMCTQVSGDGTAVPKLSLSSTTKLQTCSSCKLALPQDALNLTTKTPTKTNPNTCFVSTQYPVFQSRYTALTKLIMKSLSVETTSDLAKPLFIGDNLNGFSLTKIFKIKDVNARGGERKYCFMVVSDEEIKILKNWNIITSYLTELISSIQKKVQTSIEHKNKVDGKHSNLNNETYLRRSLVKPRSLVELTEDDRIFVKLHLGAIQLVKDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZP1</accession>
    <name>G3AZP1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_96754</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZP1"/>
    <dbReference type="STRING" id="590646.G3AZP1"/>
    <dbReference type="GeneID" id="18250629"/>
    <dbReference type="KEGG" id="cten:18250629"/>
    <dbReference type="eggNOG" id="KOG3949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040685_0_0_1"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="446" mass="49249" checksum="B794E71BDC6100BA" modified="2011-11-16" version="1">MSFRKRSEVINGTPRTPAVPGRAGGPSPIPGRTPTPGVPGRIPSTVPGRGPLPGRSQKAKPPGPQKSDETVSPEPELSNIGIRPSVITSQPTISTGTADLDKILAHQGLPLGASLLIEESGTTDFGSILLRCFAAQGILHNRVDEAKKSNAHVIVVGLSHEWAKDLPGMYKGSSKDKKKALIKSEENKINVSNMSQSSNTQERDLKIAWRYGLNKKVQDENLSEVNENYNHQFDITERLRPVPSANEMTFIQLSTDYKKLVSTISATIEQQIKAYSSKTIRLVIPNLLIPSIYPPSLSQSTFMIPFFHSLRSLLRQYPNHLSMAVSLPVDLYPRSSHLITTLENLVDSVIHLQPFNQAMSQLIERAYKNEPGKIQHGLVNILKLPVLAERGLMTIHNGEYAFKNGRKRFEIEEWGIPIEDDATDANNTPSTEGHVPEKQTSKNIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZR7</accession>
    <name>G3AZR7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112962</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZR7"/>
    <dbReference type="STRING" id="590646.G3AZR7"/>
    <dbReference type="MEROPS" id="T01.976"/>
    <dbReference type="GeneID" id="18246759"/>
    <dbReference type="KEGG" id="cten:18246759"/>
    <dbReference type="eggNOG" id="KOG0863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_8_0_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="280" mass="30716" checksum="73D2697BC33E292F" modified="2011-11-16" version="1">MFRNNYDNDSVTYSPTGRLFQVEYALEAIKQGSAAVGVASKTHVVLVGLKRNAEELGSYQKKLIKIDNHMGVALAGLAPDARVLTNFLRKQAMNSKLVFNRPLSTSSAVLSIADKAQENTQSYGSRPYGVGLLVSGYDETGSHLYEFQPSGSVLEYYGASIGARSQAARTYLEKNLEKIRESASMEELIVHGLNALRDTLSQDVELTFKNTSVSVVGKDTNFTVYEDEDVQQWLDKLDSVTNSSNRNDEDEEEDAGAAAEAEGNDAGNQDTTEDRMETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZT7</accession>
    <name>G3AZT7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal peripheral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_119351</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AZT7"/>
    <dbReference type="GeneID" id="18248695"/>
    <dbReference type="KEGG" id="cten:18248695"/>
    <dbReference type="eggNOG" id="KOG1848">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001169_1_0_1"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="3">
        <location>
            <begin position="200"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="4">
        <location>
            <begin position="885"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1540" mass="176708" checksum="23D0D724667EE5B6" modified="2011-11-16" version="1">MIAVNQLTGDLTSLLNETKRRNTDVRRSCEAALSALAKYPPNHPNDQLSPADKSKVLAPFLISCNTGNARFANLAVPAIHKLIISDAIDPKDLEPLLKSLLEATHLAIDIQLRILQCLPSLMQTYGTHIRGVLLLNLLSICSSLTSNNKSTVVINTASATLQQLFTNIYDLIPVDLAGIQLTKSVQVDENEQVELDELSYEGYLIFSDLCKLIDNDSPKYFKNLAHIKTTSALEIIESILSIDKSLFSNHRELSFLLRIRLIPSLLRIINSSTDFALIIRTMRILSVLISSQLTHLVIEGEIVLSILNHILLNNDSSVWEKYAVLELFKGLFSDFNVIQTIFELYDQDPKKKNVIQELLSIISTFLQYNSHLMRNSITVPSPQSQNQLSKQNSTVKISIMDLLDKTEPPNFIPQNYPIYLIFSILLSFTDGMAKFVQSLSDSGNPKSLEYDIDFINNLISLTYPNLSMLLKSFIHSLMDNDYFHLLIRSLQKYTHTTGLLGLNSLRDGLLTLLAESIVKQDQDLDVGEADRSVLHEQGKNLIAFGESLVESLTSGDAEKKNGSSQGDPQHKSQRSLVVNFNSRHITCLRALVNLAISLGSTLTDSWKVIWITLQWCDYYINGPNDFSFVNKKEENFIPRLSQQEVTNIKTSMSKFYDSIDDYPVESYRNLMTSLVELFESEFDDESLSESQQESLETCPYNKVYFVKEIYNVSKINPIKFLVNNGESFELISNLFIKFGITKQKGVNFNFKIYIINKFNDIIKNLTTESSKTDDNVVFNRISDICLGGLNNLVIELNKQRYDELLIINNKIEIHLIILSTLNDLIENYNKNLTTEKSWNIIFSIINNPFEFRKDELKGTINDSLNDKFSLLLNSSFNSLKLILNEFIVSLPINKFKKLIDTLYNFCSQTNDLNISFSSISYFWLIGDSIKNRFNESSQTSPSANDTLTNFKEDELVKYIESATTSDVAFYKSLDIYLLLNLIKLSSDNRAQVRDGSLQTFYEIIDIHGILFDANDWKLIFNIVITKIFVIQDLETKELKETVLLKLDGMKSIFSKFHQLLDLSFWSSLFNFGREIIKLNKVEVHIVLLKKFNDLSSIEVTDDNIQKEFFEFWCGFSIEYDFVDPDLYIECLFNLMENFPLVYRKIYHTIDEDKVQKILNVFTKCLRYPIIMNRSDDTQPTSLQSKIFSNIKLIDVNEDKINVLLIRELSNLLVYQFKVRERIETKLNNSNLKSRYKLPTFISVSNASFELVQVILNKIEDFESLISDNTIVKLIKSLLDIVENNSAGANPEKPLWIECNGLLITILQKITQHPTSMNSEIWRSILRAIKICFSSQGKDNEKLNSKQYFQITNIILPLMKDVSIIDEFLTEVYLNSYLYEKNEIEVELMAPSDSIDKVIKNLVNYNFGESFGTTKPIVFYRHNSIRLVCLQELIRFINTNDEQFSTSVKLFIARTAFALRRLVEEEQVVYKRPISRTQINELKTLLTGLYTHLNTNYHPQQYSMIQSLVGLLIRFNPFIRNLHDLGRLSEDILLKFNSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZV4</accession>
    <name>G3AZV4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112988</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684934.1">
        <property type="nucleotide sequence ID" value="XM_006684871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZV4"/>
    <dbReference type="STRING" id="590646.G3AZV4"/>
    <dbReference type="GeneID" id="18246769"/>
    <dbReference type="KEGG" id="cten:18246769"/>
    <dbReference type="eggNOG" id="ENOG502SYGP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119637_0_0_1"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21336" checksum="2A58385A962037E3" modified="2011-11-16" version="1">MFRSLQRTVLIRPFPIRPAYRGFSFTSRVLADKKGPDSNSVTKQLYEAVKSNNPSNQQTPIDDSLLDMLNNLESRPTHQNSFYDSFGLTDASQVHPRDIAKNIRITGPSAGKTLDINNGALWRGLGAMNSILKNNKVKYLVKIQKRHIRKAKYRKQKKREWWRQRFSQGFGELLAKVNDAKRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B017</accession>
    <name>G3B017_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_119485</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B017"/>
    <dbReference type="HOGENOM" id="CLU_1875158_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="148" mass="15593" checksum="E4335D93072094A1" modified="2011-11-16" version="1">MILIKLSSSVNIRSFNSACSKTSSKVVGSILSALPSSSISWASKAQSYSFPLPNTSNNCCKLSSSTSDNLEVSNSGPCLLFSHLCFRLCFLFFFLEDSISSSSSSSTMKPSRTLLMASSSSSSSSSSSEESSFMTSSPSPSDECCSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B042</accession>
    <name>G3B042_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92533</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B042"/>
    <dbReference type="HOGENOM" id="CLU_2003617_0_0_1"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="124" mass="13941" checksum="9B01C1D0196F82DF" modified="2011-11-16" version="1">MSQLDPLPINPSVTRVLLTYIRAAKYVDQSELEQKLCVICDELGVPPASLDEVVHHLNHTISFSGFKIDRCLDEVSNTLVYAFVNSSSISTQVDKTLSRFKLGELTSHQASRFQDIQRASRVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0A0</accession>
    <name>G3B0A0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_129622</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0A0"/>
    <dbReference type="STRING" id="590646.G3B0A0"/>
    <dbReference type="GeneID" id="18249395"/>
    <dbReference type="KEGG" id="cten:18249395"/>
    <dbReference type="eggNOG" id="KOG0846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000017">
        <property type="entry name" value="Mrpl10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="279" mass="31308" checksum="0A7DCF98AAAC7108" modified="2011-11-16" version="1">MIFGTLASRLPRAGLLNLWGARYSSSFLGSLAPIEGAVVSYKRLGRGQASGKGKTSGRGQKGQKARGKVPKWFEGGQTPFYKRFPIIGFKRPHRKEYNQLNLERIQEFWDNNRINLQPGELLTIQKMRECGLVTGSTRDGIKILGNGKETYTVPIHIEASRASIGAIKSIEKTGHEFTAKYFTKLGLKAHINPDRYILKKGYLPLQARPTHRRDIEFYSNPHKRGYLLKDPSLLLAHRGQTKAVKKVVRKSYLSSELEAASDAKIPDFAQSTVLKLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0E5</accession>
    <name>G3B0E5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein MutL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_119713</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0E5"/>
    <dbReference type="STRING" id="590646.G3B0E5"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_2_0_1"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair endonuclease MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="230"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="725" mass="82367" checksum="A805167047C051E1" modified="2011-11-16" version="1">MTSEDTIGTGKIRKLDPLVVNKIAAGEIVIQPANALKELVENSIDAHSTMIDILVKDGGLKLLQITDNGDGIEKEDLGLLCERFATSKLAKFEDLESIATFGFRGEALASISHISRLSVITRSKSSTFPLAYKAYYINGKPAGQNFKGTNTEPKAIAGKEGTQLIVEDLFYNLPSRLSSIRSRNDEYLKILDVVGKYAVNSDGVGFSLKKHGDFQHALMTRPGMPLKERIRMVYGAECSNQLLDLEVNGDDTEGQYLDKFGMVKVKGAITNCNFNYRKKMQSIFFINQRLVSCDPLRRAIHSIYSIFLPKGFQPFVYISLELKPEILDVNIHPTKREVRFLHEEEIIEVIVTNVHKLLTSVDTSRTFKSQNLNSKRERQEEVEYSQVAKKYRQENKLVRVDVSQPRLNELLSHRNSGSANVSKQDKFINSATRAPSLPTSESDDETRLADTKSASSDDSDIHLEIERITFPDTMVVTGRKRVSQTLDSVIELRTSVTESTNIELTNIISKSSYIGLVDEYKRLCCFQHDVRLYLCDYSALLFEFYYQVALSEFCNYGIVELSEPVCLEEQLQSLHELDTTIPLQDAQSMIQEIFNMKDMFGEYFSMNFEKTDNKHYIVSLPMLVKDIMPCLNKLPFFLYKLATKINYEDEQKCLQGIMKQISLLYLPEIVEEEDSDESTRAETNKFLSETIFPLLRTHFKAPSSLSANITQIADLPGLYRIFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0F6</accession>
    <name>G3B0F6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_119737</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0F6"/>
    <dbReference type="STRING" id="590646.G3B0F6"/>
    <dbReference type="GeneID" id="18248725"/>
    <dbReference type="KEGG" id="cten:18248725"/>
    <dbReference type="eggNOG" id="KOG3168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_4_2_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="131" mass="14622" checksum="C9D75B018C8160E6" modified="2011-11-16" version="1">MSQIPITKKTKMSELLHYRLKVSSIDGRSFIGNLLAFDKHMNLVLSDCEEVRIPKKSLQDLKKGVATEPRELKTNLGLIILRGDQIVNLTIQSPPVTNPKKRLGLEKGKGTSKPLKTPVSVKSKFKGFRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0G3</accession>
    <name>G3B0G3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_129656</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685083.1">
        <property type="nucleotide sequence ID" value="XM_006685020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0G3"/>
    <dbReference type="STRING" id="590646.G3B0G3"/>
    <dbReference type="GeneID" id="18249397"/>
    <dbReference type="KEGG" id="cten:18249397"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="759" mass="85174" checksum="713D0F7522A7BDD8" modified="2011-11-16" version="1">MEKSLSPTKSEVYVTEEPYDKVPLESEDIKYSSTEILDESADDAPLPEVRSVVRPGDDESLPINSFRCYFVAVLFTVVGAAINQFFALRYPGITVTSTLAQLVSYPLGQFLARVLPVWSMDLGRFGTFVLNPDRHFNKKEHTIVTIMANISFTAAWATDVIQAQYIYGVPAPAGYQILMVLTCQLFGLGVAGLVDDVLVKDSHNYWPNTLANVALFDSLHSNANPVADGWRVSRLRFFLIVFLCSFVYYFFPGFIFQALSYFTWICWIVPNNVVVNQIFGQIQGLGFSPITFDWSQITYANGSPLLIPFWSQIMTIIGWLIFFGILPLILYYKNVMFFAYLPISSSDVFDNTGQAYNGSRVLDISTMALNEESYKEYSPPFLAATYAIGYGVSYAVLSSSVCYVVLYHGKDIVRSLTGGVREDVHVREMKKYPAVPKWWYGLLTVLVYAATIITMEKYDSKWPVWGITIALLMVMVFILPVGIVYARTNINTNCMTVLGQIIAGYAMNPSKPIVSLAWKFYAYTGISQAMYFSQDMKLGYYMKIPKKTLFWCQLSSCIIGAFVQVGILIAMLNNVDGICSADQPDHFTCPQGTTNFAASVVWSLVGPKRLVSPGKIYAGFLHLFWIGAVLVIITWLLQKKFPHNQVLKNWNWVIVFGAMGNYPPATGLNYTSACAVGILFNWYIKRKWGNWWLKYNFVLSCALDIGVALSGVIIFLCISYPGGSLSWWGNTVFDNTADGLLTPYKAIPEKGYFGPDTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0P3</accession>
    <name>G3B0P3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_102578</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0P3"/>
    <dbReference type="STRING" id="590646.G3B0P3"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891365_0_0_1"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="304" mass="35445" checksum="E7F0165BFF04816B" modified="2011-11-16" version="1">MENLHVLMQGLPPVSRYWAGGLMLAHAMVQFKLVPGARLEFSVSRAFSTQPWRVITSFFYYGPLSMNTLFSIYNTVQWSKLLEESFSLSRATFPDSIAVFDEEQQQVLMRATRRLEPLDYFHYLVLMAVAVIGLSTYGSYVLGYPTPMMGGMLYEILTYILCRRNPQLQVGIFGIIVIRGIYIPLMSMVFALVSSEEFSILLQQLSAESFTMGSLWNVLTTFAIWRGLVCISIGHFLWFVHSVLFDTIYDDRNNKRYSLRHGTVKRVQQAQQINYIDMTKTVMRWIMLPPWYWVMIHNIKRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0P4</accession>
    <name>G3B0P4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113201</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0P4"/>
    <dbReference type="STRING" id="590646.G3B0P4"/>
    <dbReference type="GeneID" id="18246855"/>
    <dbReference type="KEGG" id="cten:18246855"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_6_0_1"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="339" mass="39048" checksum="1B4184C95AC3CE47" modified="2011-11-16" version="1">MEKLIYRDDTPLDRHDPKTTLITEPYEYLQKLPGNNRAIRIVFIKAFNDLYFGIDNDGLINGLNELVDMLHDCSLIIDDVEDSSEYRRGALAAHLKFGVPSTVNCVNYMYFVAIDKASKLAPLYTSDLHEQELITLRVNKIITDEMLNLHHGQGVDIYWRDNKSDLPRLPTEEEYLEMVMDKTGGLLRIMVKVLEAFKPSKSTKHVALTSLIGIIYQLRDDYFNLTSDKYSHMKGVVGEDLIEGKFSFPILHSLRFSMTSPLYELLYNRSVEKRKSSESHHLIAESIKFMTNESNSLEYTNNKLKECLNMARKLIETDPTVHNSDSTYILQILHQLSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0S0</accession>
    <name>G3B0S0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_92688</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0S0"/>
    <dbReference type="eggNOG" id="ENOG502SQPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098504_0_0_1"/>
    <dbReference type="OrthoDB" id="4026289at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442788" description="PA14 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="33"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="249" mass="26745" checksum="53F94B8E1000FF1F" modified="2011-11-16" version="1" fragment="single">MMNNQFSITFLFVVQLLCATTTAATIGGCSPQSVSKGLYAEYIKLTEDYSVATAKLATVALTVIDKSEAEYSWGGVTSQNFYFADRGASAVNGDLYGKTVNVGHFGLRLSGYFYASTTGVYTFEISYVDDAASITLGAGVAMDCCGSEPLTGNVDENAYLIGDDKSTTATEKVTLTAGAYYPIKMVYYQGGKKMAEFNMSVLYPDGTNHTTDIDWYSSTDNSTSCPYSTTTTIIWTGSDTETFTETASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0Z9</accession>
    <name>G3B0Z9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inner kinetochore subunit AME1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_134153</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0Z9"/>
    <dbReference type="GeneID" id="18249775"/>
    <dbReference type="KEGG" id="cten:18249775"/>
    <dbReference type="eggNOG" id="KOG4549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_799249_0_0_1"/>
    <dbReference type="OrthoDB" id="3995136at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner kinetochore subunit AME1" evidence="5">
        <location>
            <begin position="210"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="347" mass="39221" checksum="C81016FD1F843CDB" modified="2011-11-16" version="1">MLESALNEDTHLPKLRSESHKISPGTFYKPPHQIPSAPENFDQNNSELPRSTSATPSVDVDGGSDPGDVSPVVRKRGRPKKQKTPSVEPEAPKRPRGRPRKGTSNPVDTTVDLSDGSIATRRQRRRTAQIGESVASMSSLSRVRKPVPLTKQAQAGKSVQRPLNIDIDRLIVDINRDKRLKVNVLDVLKHLVKTFETPDFPTDLKNPKVIQNDFKTHLLDYLNHLADVHGSIHDLVHEINRVRKEKEEMRRNIFEIRRSYADVMNDLNKTRSQFSDSKRKYDSFISLTRELDELRSQATSSSSSGNHISSIDREITILDQLFNPINGLQVTLSQTNETLEHIDRGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B173</accession>
    <name>G3B173_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavo protein oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113655</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685976.1">
        <property type="nucleotide sequence ID" value="XM_006685913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B173"/>
    <dbReference type="GeneID" id="18247070"/>
    <dbReference type="KEGG" id="cten:18247070"/>
    <dbReference type="eggNOG" id="ENOG502QT1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_3_0_1"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="52"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="246" mass="27038" checksum="2973DE67541B83D5" modified="2011-11-16" version="1">MSSNTFWNEGPNPDWVPGQGATDDEWKNHKKIAIDPFESGRTRLHNYRLLSSAITPRPIGFISTITPEGVPNLAPFSYFNVICADPPLFSVSFSGDRNKDSLNGILHSGELTINVISEWFVDAANATAVAAPPDADEWVLSGLTPSPSEKVKPAHVAESGFSVEAKLVDSKTYYSRDKPGVVSGVVVTVEAVNFHVREDLLEDEEKMFVDTGKLKPIGRLGKNSYTSVNNGYNLKVYNYEKDFPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B176</accession>
    <name>G3B176_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">CANTEDRAFT_113656</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685978.1">
        <property type="nucleotide sequence ID" value="XM_006685915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B176"/>
    <dbReference type="STRING" id="590646.G3B176"/>
    <dbReference type="GeneID" id="18247071"/>
    <dbReference type="KEGG" id="cten:18247071"/>
    <dbReference type="eggNOG" id="KOG0567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="305" mass="34268" checksum="E0DE9E010B37A790" modified="2011-11-16" version="1">MSQDEIDIDNASLEQLRDILCNVNGKELLANRFRALFNLKCIGAESTNTEEAEKAITYIADCFQDESELLKHEVAYVLGQTHRLVAAPPLRQVLKDNNQQIMVRHEAAEALGALGDKDSLALLQDYYKNDPSLEIRQTCELAIERIKWEQSEESKTENIEKSLYTSIDPAPPMPSDVESKVEKLQRILNDQDTPLFERYRAMFRLRDLGTDEACLALASGFDDPSALFKHEIAYVFGQICNPVTVPALITVLKRETEAGMVRHEAAEALGAIGTDECTRVLESFLHDDERVVRESAIVALDMVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1D7</accession>
    <name>G3B1D7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_93181</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1D7"/>
    <dbReference type="STRING" id="590646.G3B1D7"/>
    <dbReference type="GeneID" id="18250261"/>
    <dbReference type="KEGG" id="cten:18250261"/>
    <dbReference type="eggNOG" id="ENOG502S0M8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126647_1_0_1"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="131" mass="15027" checksum="421245DEDD13FABF" modified="2011-11-16" version="1">MLRSIRQFSSTSTRAAFAKMQLLGTVGSVAARETKVGNPFITYSLAVNRYDSSEESNRATDWFNISVFNDRHISFFNEYLKPGMQLYVECDVRQRQVADESGENKRYVTNLTQTNYDVVRFAKKEEAEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1I7</accession>
    <name>G3B1I7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">CFEM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_113728</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573</strain>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686006.1">
        <property type="nucleotide sequence ID" value="XM_006685943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1I7"/>
    <dbReference type="STRING" id="590646.G3B1I7"/>
    <dbReference type="GeneID" id="90982323"/>
    <dbReference type="KEGG" id="cten:90982323"/>
    <dbReference type="eggNOG" id="ENOG502SD7M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147526_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833532" evidence="16">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV65199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV65200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="135" mass="13756" checksum="7731A00CE280CBB1" modified="2011-11-16" version="1">MVSFNALAVIALGSITSAATITTTNYATYPSVAHTASINGFADRIYADLPSCAQPCVKEDTGITPCPYWDTGCLCVMQNWDDRVANCVASACSGAQVATVTSLVTSLCSSAGVPSPYWFVGTAASNSLVTAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1W7</accession>
    <name>G3B1W7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_113316</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1W7"/>
    <dbReference type="STRING" id="590646.G3B1W7"/>
    <dbReference type="GeneID" id="18246896"/>
    <dbReference type="KEGG" id="cten:18246896"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="317" mass="35875" checksum="D6E537C1CA169F7F" modified="2011-11-16" version="1">MVQLATEVTLRMSNGKEIPALGLGTYIGSSDPTQVKDLVKTAIKAGYRHIDGAWLYGTEKYVGEGIRESIEEGIVTRDQLFVTTKIWPTYWDKPEKSFDKSLSDLGLEYVDLLLQHWPICAKDVDSSTPLPIKEDGKPYYDDPTSDGTGFIEFYRGIEKLHLDNPQKIRSIGVSNYSIMKLEKLIPKVQVLPVVNQIEYHPQLPQKDLVEYCGKYGIIITAYSPVGSNGAPVLKLPLIQQLADKYEVTTNEVANAYHILQGRASLPRSTNLERIKTTIRLPSLTKSELEDLYQIGVENPKRHITNIWGDELGFDWWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Y0</accession>
    <name>G3B1Y0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin interacting protein 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_133868</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Y0"/>
    <dbReference type="STRING" id="590646.G3B1Y0"/>
    <dbReference type="GeneID" id="18249748"/>
    <dbReference type="KEGG" id="cten:18249748"/>
    <dbReference type="eggNOG" id="ENOG502QS95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005287_0_0_1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="3">
        <location>
            <begin position="302"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="769" mass="85958" checksum="37B891822E9595C8" modified="2011-11-16" version="1">MSNSPAVSQGSKHSSKRHSTNSIESSVTRLLVSTKHLLESLTQWAKKEVDDKFVSDAYVKLGNDFRAASRAFNHAGVDISDIGDVPQALRVILESALSEAPSQENLNRFLPNIKNIIVSLLQNLKSKQNKAKLIAQDRDRSNSNSPPQDQKEQIKVIKRRQKSLESMSEDSSPQSIPQSRPQTQSIPPSQPPPLADPIANSIPKPSREKPEKKVSKEAKTERDALSQLQNESFLQRRASKRFSAYQYAKLANINPTNALPKVTPGDNRSVSIQSIRDSMRDRVSSSKTEVIDEFQKEDTYIFLKIEDQTKKAPIKMPVSFASLRLLFVEKFAYSPGASDFPEIYIVDPKTNVSYELEDQYLSDIKTGTLLCLNESKTYSNGKDSDAAADDTGSLTLDDSTHNNQSFKELEQTVSELKSKFDSFGGLIEATIKSSMKSIEIPMISAQQPTPIPSASLKNDQDSSVSNISRNGLATKNTEIPSELIKEVSSIENELKVIRQLQGANKSVVSTFVKNIDSKVKHLQESGIDATKSSNRIYMEKCHGRLSEESDSLLTKVDDLQDVMEGLRKDVAQRGVRVGAQQLKATMKEIVAAGDSLKDMSSFINKEKTVWKKIWEAELDRVCEEQQFFNLQDDLTKDLEEDLAKIQETFDLVEQCSLEQSKQSSYRRNKVVANLPIPEPGENLHSIKDAVLSEVAALKPDHESRVDAINKAEKLRQKNKQMMDLTEFQEELGSFIDDSKLRKSGGIDEIERQRQLKDSENLKSSMGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B255</accession>
    <name>G3B255_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113378</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B255"/>
    <dbReference type="HOGENOM" id="CLU_156676_1_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7110" checksum="FF719B47145E439E" modified="2011-11-16" version="1">MSYNQGPPQGGYYQQGPPQGGGYYPQQQPVYVQQQRQDDGCCGGCCGSCCASCCGVIAGVLCCEMLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2E9</accession>
    <name>G3B2E9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_113445</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by a SNO isoform. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2E9"/>
    <dbReference type="STRING" id="590646.G3B2E9"/>
    <dbReference type="GeneID" id="18246961"/>
    <dbReference type="KEGG" id="cten:18246961"/>
    <dbReference type="eggNOG" id="KOG1606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_1"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="274" mass="29557" checksum="9E46893976763B25" modified="2011-11-16" version="1">MDVVNAEQAKIAERAGACAVMALERIPADMRASGQVCRMSDPKMIQEIMAEVSIPVMAKCRIGHLVEAQVLEALEVDYIDESEVLTPADTKNHIPKSKYKVPFVCGAKNLGEALRRVSEGAAMLRTKGEAGTGDISEAVKHITQIKEEIEYVMSLKTDGELEQFAKENRIPLDALKQLIANGGKFPVVNFAAGGVATPSDAALCMQLGCDGVFVGSGIFKSKNPEKLAKAIVNAVTHYNDPAKVLEYSTDLGELMFGVSISSLRDNEKLSSRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2H9</accession>
    <name>G3B2H9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_120522</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2H9"/>
    <dbReference type="eggNOG" id="ENOG502QVX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062645_3_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="169" mass="19456" checksum="9A484DDB0B22FCB8" modified="2011-11-16" version="1">MPEIEKLVFDGILSKEFHDDVVIMGKVRRTHKIPLLVKVSNIILSLSNWTVLPYLLGRSLVIFLCGLVPFVGAMLIAYIKAPRRGLQAQHRYFFLRGMSQQQIRVHYKTKKPEYIGFGLVANLLESIPLFNLLFIFTDTIGAALWVVKIESERKLNMLKEELNKEVRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2T1</accession>
    <name>G3B2T1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carboxypeptidase</fullName>
            <ecNumber evidence="12">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_104498</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in degradation of small peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="12"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685561.1">
        <property type="nucleotide sequence ID" value="XM_006685498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2T1"/>
    <dbReference type="MEROPS" id="S10.001"/>
    <dbReference type="GeneID" id="18245723"/>
    <dbReference type="KEGG" id="cten:18245723"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005131607" description="Carboxypeptidase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="515" mass="58072" checksum="79E082E1A8E69BF8" modified="2011-11-16" version="1">MKLSLTLAAFSLAGYVLSLAVPQTPFQLNTNPFIQSIEDQLRLNKLDPKIHQFWQHTLATDREQVSRISQGVPGKEFNPQQFENTVVHEKVASHVLRYKSVPKHLGVDTVDQYTGYADIMEEDKHLFFWMFESRNDPTTDPVVLWLNGGPGSSSMMGLFFELGPSSVSPELKVVRNDYSWNNNATMIFLDSPVNAGFSYSSHDVNTTVSTSEDVITFLELFFKGFPQFTKVPFHISGESYGGHYVPKLAKDILNKKDKNFELQSILVGNGLTDMLVQYEYYQPMACGEGGYPAVLDEETCATMKANIPECIALIAKCYDSETAADCYAATELCNEQQIQPCAEAGTNMYDVTLECKGENACYTEIGDMERYLNSTAVKDAIGAEIKSYHSSNPYINKHFRMMGDWMQPYFRDAIHDVLEQGLPVLLYAGDKDFICNWMGVEAWADRLQWSGAEGYSTSSVEKWYNGDIHAGNVKNYENLTFLRVFGAGHMVPHDQPQNSLEFFNRWLAGDYALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2Z6</accession>
    <name>G3B2Z6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114079</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2Z6"/>
    <dbReference type="eggNOG" id="ENOG502SBX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188562_1_1_1"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034595">
        <property type="entry name" value="NDUFAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6602" checksum="6B5C61DC1E5A077B" modified="2011-11-16" version="1">MKVRPAKKFIDVSAKCSVEGMAYGQCILKNYATISKDSCQAEFSSFKSCVQKQMSGKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B325</accession>
    <name>G3B325_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 17">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 17">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 17">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTEDRAFT_114096</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 17"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B325"/>
    <dbReference type="STRING" id="590646.G3B325"/>
    <dbReference type="GeneID" id="18247261"/>
    <dbReference type="KEGG" id="cten:18247261"/>
    <dbReference type="eggNOG" id="KOG2386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021710_0_2_1"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000542">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 17" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 17" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="20">
        <location>
            <begin position="36"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="21">
        <location>
            <begin position="238"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="367"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="18">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV64064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="426" mass="49346" checksum="95031F018407E513" modified="2011-11-16" version="1">MPVIPGEKLPREESYELQLMVADLLNRKNPNFPGSQPVSFERLHLTDTLMKKDYYVCEKSDGLRCLLFIINHPERGEGVFLITRGNEYYYIPNIHFPLSMNEEKGKTFHHGTLLDGELVLETKNVSEPYLRYCIFDALAVNGKDITGRFLPTRLGYITEQVMKPFDNFKRKNPEIVNSSTFPFKVSFKLMTSAYHADDVLSKKDQLFHESDGLIFTCAETPYVFGTDTTLLKWKPAQENSIDYKMEILFNKYQDPDMDPRDPDSTYTDYDSNPDIINLHVWKGGRDYEQFARMYLEEKDWELLKSLKEPLQGRIVECKKKVDLPGYWEMMRFRDDKSNGNHVSVVEKVLLSIKDGVSEEEIIAACPKIRDSRKDKRPKSAPAPSHAHSVKDQHPKKRSREGDADEVQPAAKKFEEDMPAYEDSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B339</accession>
    <name>G3B339_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_104644</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B339"/>
    <dbReference type="STRING" id="590646.G3B339"/>
    <dbReference type="GeneID" id="18245740"/>
    <dbReference type="KEGG" id="cten:18245740"/>
    <dbReference type="eggNOG" id="KOG2013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_7_3_1"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000004">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 11 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="16">
        <location>
            <begin position="8"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="17">
        <location>
            <begin position="308"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12 15">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="123"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV64072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="608" mass="68556" checksum="1AD7CB36D1C9F27E" modified="2011-11-16" version="1">MSKDLYLKKILGEERFSLIRGSTVLMVGAGGIGCELLKDLMLTGYGEIHIVDLDTITLSNLNRQFLFRQKDIDKSKALTVVKSVSKFNYFDSKLVPHHGNIMDTSMFPMSWWSQFDYIYNALDNLEARRYVNRMALYLKIPLMESGTTGYEGQVQPIYPYRSECFECQAKVTPTTYPVCTIRSTPSKPVHSITWAKEFLFQQLYDDSTSSATDAEESRKQLEKETDDSAEIEHMLRETNELNDLKSHIAGGADVFLPELVEKIFVRDIERLLEIESLWKHGGRPVPLDWSQLKPQLDSLLLTSTDLVDETKVQTPLENLYVLWKSGEKLVKRVVSGEPVVFDKDDEDTLDFVVAASNLRSHIFGIEVKSKFDIKQIAGNIIPAIATTNAIISGLSVMESLEYYKAKDSQAAFSNSSTVFVSIKPNKYLMGAGLVEQNSSCASCFKVARGVMELPETSGDLKLGELLEGLRQTYDYEDDHYEISIISGDSRLIYDIDFEDNIPCGLDELGIGIGSTLLIQVDEGDLQGLELYISKGKEFKLPQIQLRELPKTISEPEKSEAEVEKDGEVVFDDGVIEIEEIEEIEEIEDIRETATKLSSQEPPTKKQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3K9</accession>
    <name>G3B3K9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hsp70 nucleotide exchange factor FES1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Hsp70 nucleotide exchange factor fes1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114241</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FES1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3K9"/>
    <dbReference type="STRING" id="590646.G3B3K9"/>
    <dbReference type="GeneID" id="18247330"/>
    <dbReference type="KEGG" id="cten:18247330"/>
    <dbReference type="eggNOG" id="KOG2160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046722_1_0_1"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="288" mass="32272" checksum="36CA3754A2AC54BB" modified="2011-11-16" version="1">MDKLLAWSLAQQSGDKEAMAKIGQPDMKALNSLFGGVDEPTLMTQAMLVAQNPEASVEDREVALENFEMLIENLDNANNIENLKLWPAVISLLDESVDSSLRVLAASIVGIAVQNNTKSQEDFLKYDTGFKSLVQYSVDPSTSVELKLKLLFAISSLVRNNQDSFKFFNKLKGWTILTLLDKHDNHKVDIRVLSVLSSVLTSESLFKSEIEAKLHEYKLVDKLINSLLNDNITCMEKSLSILGQLISLNFKFEAGELKLLSKNIDKISHLKEEYSEDFAKIRKITKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Z8</accession>
    <name>G3B3Z8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_130271</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686213.1">
        <property type="nucleotide sequence ID" value="XM_006686150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Z8"/>
    <dbReference type="GeneID" id="18249438"/>
    <dbReference type="KEGG" id="cten:18249438"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="78"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="536" mass="60945" checksum="26E307B7696FFAF5" modified="2011-11-16" version="1">MRTVSSSNSSRLGEVDMLKESVNHVENVETNSFQNKEVGDELATEKVDKQILDYIQEDAIEIDEETNRRIRRLVNKRILPCMIGTYFLQALDKGTLSFSSIMGIREDAGLVGQQYSWLTTCTYIAVLVFELPTNVIIQKVPVVKYLTANIILWGIVLGCHALGKNFPILVAVRTLLGLFECCCQPCFILMSSMWYKREEQAFIVALWYMMNGGQQIVGGLLSYCFTLIEGAALKNWEILFLTYGCITVVWGIFLFFYTPDSPMSAKCFSEEDKRLMVERVRSNQTGLQNKKFKKEHLIEALKDPQAYCYFFIQFLTSLPTSGLGAFANIIIASFGFTVLQTQLLSMVLGAYLIFLLLSSAYFSKRFNQNIFFMIMYVVPSIVGTVVLMTLTYAEYDPDSYQHKLRTGVLLFCYYLTLSFWGVANLGLSLLSRNIAGQSKKAVCTTMNFVGWAVGNIVGPQVFRANEDPRYLTAFGTHLGCYAALILLLLFLRLWLMRENRRKEKLIESGVATADVHLKHAFDDLTDRENVNFRYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B468</accession>
    <name>G3B468_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_121459</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B468"/>
    <dbReference type="STRING" id="590646.G3B468"/>
    <dbReference type="GeneID" id="18248848"/>
    <dbReference type="KEGG" id="cten:18248848"/>
    <dbReference type="eggNOG" id="ENOG502SDTR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031972_0_0_1"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="514" mass="59743" checksum="973899A455152D23" modified="2011-11-16" version="1">MGVCKGLVIDRSVISEFAGKISLKGLKDIKVNLENELKSLTSPMRFSFSNTTVEVSKNSEDFIILPPDLVSSDIYEKLGLEFLNEDGYKFKLFDKDLMIPKDFKTLFLYNTSTPLSIPTSKHDNLAKFIDESLPFNLPPYMNLINHYLVLPRSYLNEKLKTSGEAFETLAKLSSMFSRGILISSSSYLPIFRAVMSENVPFMVFMFSDSTIDKFEEQRNPIMTVKNYLGTEKNIISNFFDTFAENWINNINYDSLISSVFCTTNSNNLTDSYCLKIRDKNALLLFPAFYEVSQLLNFEEQEPQLMKRADEPLAEAQVVRQVHNRLSNYAEKFNDVSYEFATEPKQLIERVDERLDQKSYKFFDKIDEKTDNIADKKDSLVHQVADKVRMIKGSLDFKELFNEDYDTKESDYDVDGDNLMGKRTVEEEEDNLFEYQQEEGIVLPLSLVRVEEYSLSSPRHKKFSQVLFEDTDDNEHTLSKRFTIFSTDEDCEKITWYKVFHYSIFGKPRFCLSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4C4</accession>
    <name>G3B4C4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113974</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686264.1">
        <property type="nucleotide sequence ID" value="XM_006686201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4C4"/>
    <dbReference type="GeneID" id="18247201"/>
    <dbReference type="KEGG" id="cten:18247201"/>
    <dbReference type="HOGENOM" id="CLU_692603_0_0_1"/>
    <dbReference type="OrthoDB" id="10015850at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="47101" checksum="2A4D87B83A6831D7" modified="2011-11-16" version="1">MGFVNIGKPYNYKRSRDRQPKKHKPVEKTLQLTKLPIELLFNIFCYASVSENNLALVNRYFYKLFRPANLGLHYLQKFIQCRFVVDLNNKCTRILSDIDEMFEEFDSGSELREIFDPFKKSLNYIKTHQWGFNIDAFKYRFTYELDAEYFKQFCLISSKHISTEQAKRLRFIHNQLRLLQYQLQRWESRQQHRHRYDWDFSETILPLRHSTELLLTISEEPLAVLSEDDYENERAEIASGVPVSNIDAIYNSDFGAVVEEVYPTINSMNQFHKVVVLIDALGMKFKDKNNFMITIIDGNLQFKDKTKILKYMHKTFFQKAENSPSLSVSFILKLFQLLSSSSYDAKFEKVVHKFLRHFYGTGDDLANFDLDLWNYIKEAKDSDLFQILCGYSTPSFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4W8</accession>
    <name>G3B4W8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_105528</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4W8"/>
    <dbReference type="GeneID" id="18245818"/>
    <dbReference type="KEGG" id="cten:18245818"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="54"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="550" mass="61387" checksum="D87118BFC9F57EDB" modified="2011-11-16" version="1">MSDSSPVPSGTQTPVDNTSVVEHKFEKEEQLQEERPTLEDQDKSFKDYLSISFFCLLVAFGGFVFGFDTGTISGFVNMTDFKQRFGQLSGSGEYYLSNVRTGLIVSIFNVGCAIGGIFLSKSADMYGRRIGLMFAMAIYVVGIIIQISSTTKWYQYFIGRLVTGLAVGTVSVVSPMMISETSPKKVRGTLVCCFQLFITLGIFLGYCTNYGTKTYTDSRQWRIPLGLCFAWAIFMVVGMVSMPESPRYLVEKDRIEDAMKSISRANKVSVDDPAVHAEIELIQAGVNREKLAGNASWKELITGQPKIFQRVIMGVMLQSLQQLTGNNYFFYYGTTIFKSVGLTDSFQTSIVLGVVNFASTFVGIYAIERFGRRTCLLVGSVSMFICFIIYAVLGSVHLYIGGYGGETRTSTGNAMIFITCLFIFFFASTWAGGVYCIVSESYPLRIRSKGMAVATAANWMWGFLISFFTPFITAKIHFYYGFVFSGCLLFSFFYVYFFVSETKGLTLEEVDELYRQNIAPWKSGSWVPPTNAEKMAYASGFERSEHDTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B537</accession>
    <name>G3B537_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_134962</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686921.1">
        <property type="nucleotide sequence ID" value="XM_006686858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B537"/>
    <dbReference type="GeneID" id="18249826"/>
    <dbReference type="KEGG" id="cten:18249826"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="138"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="662" mass="72686" checksum="F04C8AFAB4716E12" modified="2011-11-16" version="1">MDIKNVDTPQAHEMSPYHSGDSEYISENGSLTSTSSLQSEYEPNPVKRFFNSFKPYDYSKIDFLLYQDDDLESGGSYDFGPQGSPPATGPSRSPNQEEKKKKSKRLHPQFDYSRLSDLERAAIVTSTSPLSRTLKSRHLSMIALGGAIGTGLFVGMGSALASAGPFGLLIVWVFIGSAIFVTASALSELAVAFPISGAFVTFNTLFIDSSWGFAMAWNYALQWLVTFPLELVSASITIQYWNSPVPPEVFVAIFWFIICAINLFGVRGYGEAECVFSMIKIVAILGFLILSVVLVAGGAPPNHDFIGGKNWHQPVGGMFNTTEPFKNMCAVIFNAAFSFAGVELFGLAAAESANPKKSIPKARKQVFWRLLFFYISSVIMIGLLVSYKNPALLGQTDTNAEVKEKGIDANTSPFVIAVKQAEIPAIPSILNAIIIITVLSVGNSSVYGSSRTMAALGAMKQGPQILNYIDRNGRPIVALLVQFVIGLLAFLVALPGDKTTQVFDWLLAISGLCSLFTWWSICLSHIRFRAALNHQARVAEEELVFTTSVWGSYYGMVILTIFLGLQFWAALFPPGEGGADVEGFFMVYLGGVIVFVCYVGHKIYAALYMGIPLTKFYLKASEIDVDTGRRQVDMEALRQEIADERALYESKPFYFKIYTIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5B9</accession>
    <name>G3B5B9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114497</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5B9"/>
    <dbReference type="STRING" id="590646.G3B5B9"/>
    <dbReference type="GeneID" id="18247449"/>
    <dbReference type="KEGG" id="cten:18247449"/>
    <dbReference type="eggNOG" id="KOG2646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037994_0_0_1"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000041">
        <property type="entry name" value="37S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="158"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="320" mass="35641" checksum="30F93741113D708F" modified="2011-11-16" version="1">MFSTVKSSIGPQLIRSLSFSPMARQSTKRAEEHIAYLSKFYTPELLQSIKITESLVEPDTILKLTKQGPNALSKLGLQNTDYSKTDPKWDEPVLYPNQAVNKTPYPNIPQVQAPDRSDLKLRFSPGKGPRKDNFATSRGVSEGLSKLTGLDKRYIERLYVRPVVMKRVSCQTSKGKIPNFFALTVVGDGNGMVGLGEGKSRDGMRTALVKAHWNAVKNLAPVQRYEDRTILGDIDYKYHAVKLFLQSAPAGFGLRVNSKIFEVCQAAGIKDLRGKIYKSRNPMNVVKGFVEALTKQRGLQDLAGGRGKKLIDLRKVYYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5W7</accession>
    <name>G3B5W7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_130808</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5W7"/>
    <dbReference type="STRING" id="590646.G3B5W7"/>
    <dbReference type="GeneID" id="18249479"/>
    <dbReference type="KEGG" id="cten:18249479"/>
    <dbReference type="eggNOG" id="KOG2187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_3_2_1"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="543" mass="62396" checksum="B62AB2B262F02B10" modified="2011-11-16" version="1">MWICQIRQSSMIRLLQRPYSENITRIQLRSIFVGYLKILNKKTRRDTRDETSRRNILNREIQECLNIFDKGSDTRLGLDDVRNGPDVLQQFIFTKTRPYVELKDIEILYMTSEGEGLGVVPKIKYIDFKSGENGEFSVVKIPKTVPGDIVTARLLMHQHNHVEGLLVKVQNEGSRNSIRNNRYIVCNKFNECTGCNFQMLSYDDQLNLKQKTIQKAFRYFYPKIFDSIPMNNFGVVSPSPVEYSYRTKLTPHFTYKRKIEDVAIGYNHIDPTKGTIDIDHCPIATRSINQELVKLRSSTLEGMASRQPKHSQSTLVLRESIRINFKTGDHNTVCLTDPNKVVTEKVGDFVFQFPVNEFFQNNNSILPLVLEYIKYHFEGLEFKNLIDTYCGSGFFGISLSKEVPDDGKVYGVELAKKSIEYATHNAKINGLKVPEKVYFIHGSADEIFTNKVLKKANIIGSDSVVIMDPSRKGSNKDFLEQLFAFRPKLIVYISCNVFTQARDLSQFMELQGETPAYRIKDVTGFDFFPQTKHVESVAILELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Z7</accession>
    <name>G3B5Z7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_94107</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Z7"/>
    <dbReference type="STRING" id="590646.G3B5Z7"/>
    <dbReference type="GeneID" id="18250360"/>
    <dbReference type="KEGG" id="cten:18250360"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_0_1_1"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="97"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="309"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="496" mass="56545" checksum="B85D98A41CC39E5B" modified="2011-11-16" version="1">MLRSLGIRSCTKPCTGPQGNISIQLRTSTSSSKKPRAFPITPFSYIDEDFLSVVNRQEIAQHLDNLGPYPSYSNILNPQHFYQNEILMEYSRKDPHPVSLRQLAGYGKKLNKEKILNSANFVRLELPIRLAIRIRELQTLPFGIVNNFHFLQIYDSYYHSFNAFRKMPKITSLPENEKFCKQLSVLLDDHVFNLSHLMMGALEVSILQKFPQEELDEFMSSMIRSRISRRVIVEEHLSLTENYMSMPQEVKPPDYIGEMFDHCDAVTHLNVVAELVKNSMYPIYSNKENMPDLEIEGDLNVSFPFMKPHLHYLFGEILRNSYEATIRKHGTKTSKKLPPIKITIINTAQSIIFRVSDEGGGISHDKLANIWSFGKNPEFARKSLANFHRIPGLQLYSNLKVTAAGSSVIDEEMLNQTAIGDINSHSLTKSKKSTLERLITRSHEHKLGLGLPMCKVYADYWNGDLSMNSLEGYGSDTSLTLSKLGLYSSKTQLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B636</accession>
    <name>G3B636_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114678</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B636"/>
    <dbReference type="STRING" id="590646.G3B636"/>
    <dbReference type="GeneID" id="18247532"/>
    <dbReference type="KEGG" id="cten:18247532"/>
    <dbReference type="eggNOG" id="KOG2826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059439_1_0_1"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="335" mass="39173" checksum="D51DD2E5B2702CAA" modified="2011-11-16" version="1">MLQIESSNLLLEKTIRECLSTEIESLKGIQRTFTDFDFTTYQVSNSTAKHLVVVSIYVKCWSDLVNYGVEEYLEAKYAKFNKVLQKIETEAGYDFSFVLDLSVAQKEDVEFKEELVSELANLKRNSIAAPFEKAFSRYDELAETYANSNVYSEEVKQELENESILTINYRGLDESIYIKPSFDRVTVIFSTIFKDETDKIFGRVFLQEFVDARRRTVQTAPQVLYSHIEPPLDIRNVIQGRADDNKGYVTFVLFPRHLVKGDRRQNCISHIQFFRNYFHYHIKCAKAYMHSRMRFRVKEFLKVLNRAKPENVDDEGKLIENRKTASGRRFEVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6C8</accession>
    <name>G3B6C8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_106436</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687228.1">
        <property type="nucleotide sequence ID" value="XM_006687165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6C8"/>
    <dbReference type="STRING" id="590646.G3B6C8"/>
    <dbReference type="GeneID" id="18245884"/>
    <dbReference type="KEGG" id="cten:18245884"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_0_1"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="294"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="578" mass="64917" checksum="D5C26C280E83FE7A" modified="2011-11-16" version="1">MYTDKTSQLPLAGVHHSPPSRLWWSRYKALLVLLPGFYFLLTYHQVPLISTKGTTSFCPEVAKINPLDVIYSQETLQMLLHNQTFKLESAKRLAAAIQVPTEVHDDMLNPNTTDSYDDLYKLEPAWKNFEFFHSFLEETYPLVHKHLKVEKVNKFSLVFTWQGSDSTKKPLMLTAHQDVVPVQKETIPQWDYPPFEGVIANGSVHGRGASDCKNLLTGLMDTIELLLAEGQFSPERTVILAFGYDEESEGTGAVAISEFLLERYGKDSMYQIIDEGGSGFTEQNGVNFILPATAEKGHLDNIIELYTPGGHSSVPPPHTSIGIISELVSLVEKTPFDSIITPRNPVLGMLQCVAEHSDIDKSMKSTILKAHVDKKANKNLLKYLSKEIRTKYLVTTSQATDIISGGAKANALPEHAQVLINSRVAVEESIKSTSDKILGNVLSIAHRFDLGVYFEGEQLLAPTENGYFNYTLFSPLEPAPVTPMYSDVWNTFGGSLRFLYEDLVFPQDDKKFVFAPYLSTGNTDTKCYWDLTANIFRYMPGFPGPDRHVHSVSEFVPIESHSLIVAFYYYYIQLVDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6H8</accession>
    <name>G3B6H8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114783</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6H8"/>
    <dbReference type="STRING" id="590646.G3B6H8"/>
    <dbReference type="GeneID" id="18247576"/>
    <dbReference type="KEGG" id="cten:18247576"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="49"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="319" mass="36211" checksum="734FCBE6AF57EABC" modified="2011-11-16" version="1">MDSVDSKAIELFIKSPIDQDLVQKVIVKTLQIIPCDKNSTVYVDDDKKLPSVSKFLNTLIQALDLNNGILMSTVVYLNRLKSKLPKNCKGLTSTRHRILLSCLILSIKFNNDFSMKNYDWLKLTNKLFNLKDINLMERQLLYLLNWHLLVNEFELFHHFSQLLCPIKDNLMNKYRMKQYLKQQQKLHATSPKILASSPQTGTGPFPAPPITPISASPISSQRSFESHPISSTFSTIRKSSSASIYSSSSAESAFTCDRSRPSPNSSFDSLDNISMESIEPTTQKLRSIPVDVNPLIELTALNEQYQLNKLLESFHHTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6M8</accession>
    <name>G3B6M8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_106557</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686766.1">
        <property type="nucleotide sequence ID" value="XM_006686703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6M8"/>
    <dbReference type="STRING" id="590646.G3B6M8"/>
    <dbReference type="GeneID" id="18245898"/>
    <dbReference type="KEGG" id="cten:18245898"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_10_0_1"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="234"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="46157" checksum="0904826E8B4DDC27" modified="2011-11-16" version="1">MPSVEDIDIKYNVRPFVDAPPSNSNVDTLKLQAVDISLFKEGDEYLDQRKQLAKTLEESITTYGFFNLVNYGISPKETEYIRAIAYSVTTLPDEVKEKYLASASKKELETTKTIGGERGQGFKPKGYWAIKNNVRDSIVHYNFRDSCFDSFLDQYNEHPELVAYHLKEIAHYYNTIHREVLPKLLTLCDIILQVPEGTILKNYFQNSGTNQDDSGSHGRFMLYQPYSKEEESSVTENTWLRGHSDISAFSFITSQPMLSLQIKDYFTGDWRYVQHRPDSLIVNIGDAMEFISGGLFKACLHRVVEPPADQKQFERLAIIYFCNPSSKADLDPENIHSPKLASLGLDKDHKLKHWEKIQFHHWNYTKGHLLGRSAAGERNLVQFFGRTIERWHHFQGGITNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Y6</accession>
    <name>G3B6Y6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_106041</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686843.1">
        <property type="nucleotide sequence ID" value="XM_006686780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Y6"/>
    <dbReference type="STRING" id="590646.G3B6Y6"/>
    <dbReference type="GeneID" id="18245859"/>
    <dbReference type="KEGG" id="cten:18245859"/>
    <dbReference type="eggNOG" id="KOG1967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005943_1_0_1"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="6">
        <location>
            <begin position="45"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="5">
        <location>
            <begin position="598"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1056" mass="120583" checksum="C80B533901CC8BCA" modified="2011-11-16" version="1">MSDPATLITQFVTFSGAEDSENAAKYASSLADLISTNKLSFLQFIQLLGSRITSSIDEDRTKGMRCLAAVLHEITSSSSALSKHDINVLVDFLLTKFSDKPCFADVIKALTNILHAKAFSPSLNDNLVKILRKVVDEYDSSVHLARGRYEVFALLQTALTRFRDAITTRPALHDLYVQAFLHVSNGEKDPRNLLISFDLNKNINHYFRFEVATNELHKHFVEELFDTCFCYFPISFRPPPNDPYKITSEQLKTSLRSTLTSQFLFAKDLFNNLFEKLASTNPVIRNDVLLTLLSAVDSFHEDTILEYWETIWNGLKFEILHSENTNIFSVSNDRFIPENIMDLADSDENKSLYLVLEILSRMATRLDDEDGLLPGITSDLKEYLSITSKVFMKAVILLSSMATASERGFNYIQQFIFQSENLGKFISGFDDTDDNMETDISLTVARQRDLIDAFGYILISYQVLSSSLPNASFFFESNYLSQVKDSLVVFLGQLLQASSTIEKTLKCKIIQQYIKLIQLRRFLSYEEKHVIMELLNDMFFELIEEAKPDDLIVDEIMKGLINLTEDGSDQNNQLIVDVFLPQVLQQIDPQNQKLSKYVEVLDSVVVSSQLLEVVSIRLVNRLSNDRDFNSKIIELLGSLVMKVQKRSQFLMNSWFKGIVPKLLNQAAEVEASGVNNSDNWHYLELISVLLGFVIKYYDSPKHQGILDDFQSAFYKNKAKSGLKLSGYTILEVASPMVLVFNNVLSNIDKSTNLSIQLEDLVRLIETTSNLRDPILKVNYLQHLCLLVNKFYKDDDSLQPVVEKLYDLQQPSNFEISVWIIKALMLRLSKVGIEYLTKLLEVLDHDASQATIVLRSFDIILRDLKIFSPNKELPKGSKIISKVNHLNTRSLYKQQVFNIVLAKVLQQPENEIHLQLLAVLTKNIDSHVLKSRINDIIPLTIQSIQLNTLLDTSLETLLIIIDSNNLQNFMPLLVKRLMVLSNTKVVENNRIVNTERIRYLSLKCLLELLRTNDKSTILLYKPEMLVGLVTNLDDPRRSIRKLSCDIRQLLFEAREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B732</accession>
    <name>G3B732_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114396</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B732"/>
    <dbReference type="STRING" id="590646.G3B732"/>
    <dbReference type="GeneID" id="18247404"/>
    <dbReference type="KEGG" id="cten:18247404"/>
    <dbReference type="eggNOG" id="KOG3204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_0_0_1"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="200" mass="22622" checksum="E2508E349C0274CB" modified="2011-11-16" version="1">MSAYQPVVVIDGKGHLLGRLASTVAKQLLNGQKVVVVRCEALNISGEFFRNKLKYHDYLRKGTRYNKTHGPFHFRAPSRIFYKAIKGMIAHKTPRGKAALERLKVFEGIPPPYDKKKRVVVPQALRVLRLKPGRKYTTVGKLSSSVGWKYESVVDKLEEKRKLQSAEYYAKKKALLKKIQSAKASVADSEASQKLAEFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7H5</accession>
    <name>G3B7H5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115740</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7H5"/>
    <dbReference type="HOGENOM" id="CLU_2512404_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="85" mass="9480" checksum="CCB703576C371F4F" modified="2011-11-16" version="1">MPLLLLQLYSYTPPPDAITQSTSLQPVYCRAHKPSKPSKPSKPSEPSEPSEPSHSSTLVARQLSVVFPRFFLDTKTGFPNNRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7I2</accession>
    <name>G3B7I2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115082</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688756.1">
        <property type="nucleotide sequence ID" value="XM_006688693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7I2"/>
    <dbReference type="STRING" id="590646.G3B7I2"/>
    <dbReference type="GeneID" id="18247712"/>
    <dbReference type="KEGG" id="cten:18247712"/>
    <dbReference type="eggNOG" id="KOG2069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044223_0_0_1"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="425" mass="49189" checksum="3AC6183618FD2333" modified="2011-11-16" version="1">MTSILLDTLVEDLEGPLREFLGANPELREVSESFLHDLLVNDDLLSTDTFTTSSESTRNKTLTEEIAELDDSSRVANRRLAQISNDNRDLIIRVSQDLKHINQSITSEMKTQVESMIKGLKADDKRLHVPANDQLTAAMETNSSILSNIDSILDLLELPTLCKICILQGNYQEALEISILSRNLTIRFPKLPIFSKIYEQIKVELKLMVKNLIKLLNTNLRQNNLIKIFNILSKLDLLNFRQSDIISSSNSAERTRFLKLLYFNSRYKYIINETSNLMPLIKFNRFSYLKRFIEVYRSEVYHSLSMFYTIINHSLNLESNEKEDNLLINQFVKNLAYHLINELKLHLHQLSIESKQSDDPDKKSDFSTQIDGLILQIIYLCKSLAKYHQSFENIIVWELCYNSKETLISEADWLANVSKVKKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7K2</accession>
    <name>G3B7K2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_124567</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7K2"/>
    <dbReference type="STRING" id="590646.G3B7K2"/>
    <dbReference type="eggNOG" id="ENOG502QRI1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077448_0_0_1"/>
    <dbReference type="OrthoDB" id="3981148at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="3">
        <location>
            <begin position="194"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="323" mass="36943" checksum="9853BCE919C2EAAC" modified="2011-11-16" version="1">MSQQAAFSSIDHVSLESHPFMKRYVFIEIIKYHHAIDMILSLHYSSHTSLITAHALFERVAPLIQKRTKISALQSVLMVDPNCYKLVSPTNVTDYSPCYVALFDPINQFNQSLESRKLRFISSINNWITTHQEIGYLKIPSITQIIEKHSANTSKSSSPSKVLKPRLTLKNDSSKFQFKSRDEKTQSSKSNGLSLLERIKLKEQQSKQQKQQETPEAQREDYLQGKLESIYNIIYQINGEQNKPTSFTLTGLTQIVKDSLHYPTHEEDIQECLELLAKRLNHAIIITTRGGLSVVKVMKLDREGDLESLKSNKTVHAFYTACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7N4</accession>
    <name>G3B7N4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydralase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_94542</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687826.1">
        <property type="nucleotide sequence ID" value="XM_006687763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7N4"/>
    <dbReference type="STRING" id="590646.G3B7N4"/>
    <dbReference type="GeneID" id="18250410"/>
    <dbReference type="KEGG" id="cten:18250410"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_1"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="231" mass="25420" checksum="CFFF96B718709729" modified="2011-11-16" version="1">MSLKYLDNARKILCIGRNYAAHISELNNAKPQQPFFFLKPSSAILRPGEGALLIPRGTVAHYEVELAFTLNRDLKNLSPDFSAEEALESIDGYAVAIDMTARNVQDEAKKKGLPWSIGKGFDTFLPMSNFIPKSKIPDPYNVTLSLSVDGVTKQHDKTDLMLFPIHKILSHMSTIMTLQKGDLILTGTPKGVGPINPGSVMKAELSYGGEVLETIEVAAEEKPGPYQYKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Y0</accession>
    <name>G3B7Y0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_115143</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Y0"/>
    <dbReference type="GeneID" id="18247739"/>
    <dbReference type="KEGG" id="cten:18247739"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442871" description="candidapepsin" evidence="14">
        <location>
            <begin position="25"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="72"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="389" mass="41485" checksum="6B0D201B39E3751F" modified="2011-11-16" version="1">MFANFKVLYAIALALSFATSNAAAVPGFQKRENGAIKLDFNIERPDKLILNGNFTKRADDYNYALINEGSYYVAEILVGSNQQAVKVDVDTGSSDLWVVDTSSGISGTYGVYDHTTSSTFSRIASGFAVAYADQSHAEGDWVSDTIQLGGTGGPSLKNQEFGDATTSTINFGILGIGFPINEATADKYQNVPQSLVSQGYIHKNAYSLYLDSSDAAQGSVLFGGIDHAKYSGSLVSNPVVSQNDLDLNVNSVTTNGQTIDIGSNYVLDSGTTINYLDPTVLANLASALGAKYSSSGFYYFDSASDAKDISVNFDGVSVTIPASYTVGAFYDGDGNALTETGFLFLPQTNYHILGDVFLRNAYVVYDLDARTISLAQAKFTSDENITVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Z2</accession>
    <name>G3B7Z2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 12">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_124694</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 12"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Z2"/>
    <dbReference type="STRING" id="590646.G3B7Z2"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014892_2_0_1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="14">
        <location>
            <begin position="226"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="120"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV61693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="591" mass="68145" checksum="AC8C81E9F025527B" modified="2011-11-16" version="1" fragment="single">MAPRKRDPLEQLRIPDNRVYESIGHEINLSRADRRKSAQPVTYSLKDLIPPISLHSTRSNHRTTKPNTRASQPPQILSSEPTEEVSASKSSQLRKTAVLLDKKFMITVKYPDKYKCVFDKHKPSAKPDPKPSAKPDPKPVIRKLDPKPVTRKSDPKPNSKSEMEKPDPELDNKDLPYRGILPYPDCIINDTDPTRQDRELFQKLQEQIEKKKIPENPMTDEYESSYLKSQIKAIRFRQYEIDTWYTSPYPEEYSQCSTLYICEHCLKYMKSSFSYERHQLKNCNMSNKHPPGVEIYRDARNRVAVWEVDGRKNINYCQSLCLLAKLFLNSKTLYYDVEPFIFYVLTEIDPLDPSVYHFVGYFSKEKLNSSDYNVSCILTLPIYQRKGYGHLLIDFSYLLSRNEFKFGTPEKPLSDLGLLSYRNYWKISMAYRLRTFDVMISIENLSKLSGMTPSDVVVGLEQLDALVKNSKTNTFGIVINLEKIDSVISRFEAKGYVTLDYSMLLWKPMLYGPSGGINSTPAVVPSQNPTDNAPNSQPLHNSIGLLTSFMKDDIDNPYTFEEEAFKEVEISREAPKEFVPEELTLGNYVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B823</accession>
    <name>G3B823_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136263</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B823"/>
    <dbReference type="STRING" id="590646.G3B823"/>
    <dbReference type="eggNOG" id="ENOG502SD49">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049045_0_0_1"/>
    <dbReference type="OrthoDB" id="4023202at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44401" checksum="83A8C64B4E87C0FE" modified="2011-11-16" version="1">MYKFVYKVNEWWIIVGDGAHFYYNSVSKERSWSMPKAVDAEVLDFDYLALLFAKARGLGVEEGAERNMEVAVEETGEETGREIGDVGDRDVDDSMKTDEKHPNTHEKPSHTKAHTEPIHTTPLGLDLGYSSSDDDSGEEKADAEPEDLGASDSENDDPLTDDPQDLNDIINDVLGYSGDTHSDTDSDTDSTQAFVSLLNSLKPSINIYNPYSITEEELAEELVQHPVFYKLSPASKEKIYNDWATTAGETPSTYPSAKQVFMNKLFSIKSEVKSKYYFDLKSELAPFDYHDKESAFLMYKNILQTQTSFEKQMKKSSAPGVNLKKLKLLEFLDKHQVTTQHYQSHGSDDYQKWINMCNDLDLPAAIVENEINWLVGDSKRLECYLERGTSPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3B863</accession>
    <name>G3B863_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">ATG12-activating enzyme E1 ATG7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Autophagy-related protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-like modifier-activating enzyme atg7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_115823</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B863"/>
    <dbReference type="STRING" id="590646.G3B863"/>
    <dbReference type="GeneID" id="18248038"/>
    <dbReference type="KEGG" id="cten:18248038"/>
    <dbReference type="eggNOG" id="KOG2337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012998_2_1_1"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="17">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="17">
        <location>
            <begin position="156"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="16">
        <location>
            <begin position="265"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV62361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="586" mass="66183" checksum="6425BBCF08C85685" modified="2011-11-16" version="1">MTQLAYVTIQSFVDSSFFTRLSELKINEYKLESKPQLIFGSLTDPQKLTKFNNVPILNLDYNSFEKQDHHNISGYIHNVNTIEEFKSVGKQQLMSEWGQQLVSQLADGNDQGQFHILSFADLKKYKFYYWVAYPTANSDWVVEEQGTSSFEFDFSHQFTKVSESEYAFIDNCLDSRISSQLKNNLTVLALKGVEKVRVHVFKKEGSVFYDLKLKEPVSKESLKVTGWERTSQGKLGPKLANLGSLIDPHQLADQAVDLNLKLMKWRIAPNLNLDIIKDQKVLLLGAGTLGSYVSRALLGWGVRKITFVDNGRISFSNPVRQPLFTFNDCFADNGQGTKKAVRASQTLKEVFPGVDSHGVELEVPMVGHESSEQNYNKLCELFDNHDVVFLLMDSRESRWLPTVLGLAKNKLVINAALGFDSYLVLRHGTQNQDLGCYYCNDVVAPNDSLTDRTLDQMCTVTRPGAALMASSLAVELMVSVLQSAEGKDASANETGVLGQIPHQIRGFLHNFEQMKLMTPRYQFCSACSSQVVNRYKEEGWSFISRCLSDSKFLEDVCGLKRVQEDTERLDELFGDFDLEEEDDGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8G1</accession>
    <name>G3B8G1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115848</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689058.1">
        <property type="nucleotide sequence ID" value="XM_006688995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8G1"/>
    <dbReference type="GeneID" id="18248052"/>
    <dbReference type="KEGG" id="cten:18248052"/>
    <dbReference type="eggNOG" id="ENOG502RQE8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084555_0_0_1"/>
    <dbReference type="OrthoDB" id="4023279at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="207" mass="24636" checksum="C4FABDF05B4F87AD" modified="2011-11-16" version="1">MSQYFLLQTENYDPLVSLVESLAARLSDNDEVIARLLKVTDSLRLPRTVGDVSTDSHPQDELRYHLDTKYKLSDIQAPDYDDVANVQIRQLLRDNYRLLKIKKQNDTVNEYIFKTLLQYQRFVTTELIPMLRLDFEHSVQQSHRDLRRVLHAKLQVDASLWAKYQEYLQFLQRLFDMFEELTQMLTQLDDERVLLVEAKLEAIRQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B959</accession>
    <name>G3B959_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_126499</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B959"/>
    <dbReference type="STRING" id="590646.G3B959"/>
    <dbReference type="eggNOG" id="ENOG502RYJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010103_2_1_1"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="544" mass="62698" checksum="23AED616EB3D8409" modified="2011-11-16" version="1">MSQAIMSYIYTPSITNITMSLGSSTPRIPPHTDALIQEAFNRSTSCLELAQDVVPNGPPAPREIVAHLKLLRCFAELKKRIIASDDNEHLWKTYVTMAARRFLVFMNAIKGISTSALSETLDRMSPPIDVIMVWHSFMLKTLSFTNHCKRNQLQGFFNYSFPLKAITDLINDSTFVFVPTAQLQANFESFMQDTGSFVYDSYQMFDASMVLMIHCPVCAQDLVTIPLIDFADSRFQVSEFENCNCGFQNSMSHDELNKRIFWKDVMDFWYPVTSEYQESRIRLELVKNTFMNLVSKTFEQFIDELGSSISLKSFTQMRSYMGINPINLTIPGNAFHLQDDLVECVASQGKFITSMEQSNWIYSQLLEDIIEDGIERYKNFVLVFKDATFTVVPTLDIELVWNTHQLNQSGYQAYTQEACGKVLRHNDQIEESKLIAGFTETCRKYKELFNQEYSICFCGPCSYRRIRSRSLFSHKAKSGQTLFKANSVHHLSTCQKTESHLRFFYKQSEHYVPWEEKHIQNYVTSSLVPIYEGIETGSLFQFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9E1</accession>
    <name>G3B9E1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115955</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9E1"/>
    <dbReference type="HOGENOM" id="CLU_2739779_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="71" mass="7896" checksum="821BA8F8E0D0D1B1" modified="2011-11-16" version="1">MAAMTVQACLNSPNALNTVAALYSIKNKQTPVKMPLLPFSDTQNNFPELFFIATEEAFAHIPDIMQLLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9H9</accession>
    <name>G3B9H9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115339</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688060.1">
        <property type="nucleotide sequence ID" value="XM_006687997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9H9"/>
    <dbReference type="GeneID" id="18247827"/>
    <dbReference type="KEGG" id="cten:18247827"/>
    <dbReference type="eggNOG" id="ENOG502SEBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1982386_0_0_1"/>
    <dbReference type="OrthoDB" id="3999982at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="102" mass="11615" checksum="5A9165CBA38FD9D6" modified="2011-11-16" version="1">MIFNETRNGLAKKFGIVSVGAICLAYFGKARASSYKQGRHTNQSDALVDSQTKEFSTDYYYPGKNEENGEYKRRSEYVGAGSSYNSRRPGDRLTMFKIFDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9I2</accession>
    <name>G3B9I2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115344</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9I2"/>
    <dbReference type="STRING" id="590646.G3B9I2"/>
    <dbReference type="eggNOG" id="ENOG502S4NK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036916_0_0_1"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051643">
        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396:SF19">
        <property type="entry name" value="FI01119P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="430" mass="48170" checksum="2773916ADE25B5C2" modified="2011-11-16" version="1">MLGLLNMPFPSAASRMPSPVVGGFIQKNLLKLRLSVFQYVFKLDSLFPPIARKNIQDLSNKTRQALVSLPVACAVDDLEIYQNDKDQIYDLLENPTFYSGEYRVYETSNPQPSASSAQPSHYHTSHIKKEELELRYGSCLPEQPQQAYGTQPVYISQQSANELSDSHFHLNMVGGSDGYYFNDFKPHSANLDYYSSSTESYISPLDDELFKKKDFSVVSYHNPSIASVDFDLHSEITDASDRLDFMASISTPATSGVSTTMAAPDQKKRKNIPAKSATLKKPKIKVEEDELILADEAPGAAEDSEEEVYKFECSFCDARFKVKGYLTRHLKKHQSLKAFRCPFYNEDHQATDGSGKGTKCHPTGGFSRRDTFKTHLKALHFIYPPGTKSCERSLVGGRCAGCFSYFSNNIEWLENHIVKQQCSGTVLGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAE4</accession>
    <name>G3BAE4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein required for assembly of ubiquinol cytochrome-c reductase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115499</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAE4"/>
    <dbReference type="STRING" id="590646.G3BAE4"/>
    <dbReference type="eggNOG" id="KOG2873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="145"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="330" mass="38052" checksum="9E650EB9C1F4B067" modified="2011-11-16" version="1">MMIRTRISVRPQVFGLRWLSNQSKVNFQTQSILQQFKDKEPEMDAPSKMASESTLPHIQQDLNIKPKQAKKKSAFLSDSKEEAEGFEMSSIKQSLGQMVIKLFKIDMDSARAGSVAGSKYFGDCKKQGMYYPNEPLSDTAKFYYETLQLPQSFSQWFQITTLHYWMLAVRMRAMPFKYGKNYQQKLVDRIFRDMELRLAEELGITSNRLIENYLKEYHTQMLGCVLSFDEGLMTDDTTLGAAIWRNVLNGNPNVDMRHVEALVSYVRGNLYVLNQITDREFGFGKFEFVPPHQVVKPLTAAQKEALKEMAKKEFANKNLPSQKTVLSLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAW7</accession>
    <name>G3BAW7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114934</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAW7"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2426795_0_0_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="91" mass="10729" checksum="64B9C0E9336A5D65" modified="2011-11-16" version="1">MFTPSAFKNITWKTYMVYGSFCGAMFVHVFFFFPETKGKRLEEIGQMWDEKVPAWRSNKWEPSIPVLGSHFDDEKEHVEHVEGSDSSYKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAY4</accession>
    <name>G3BAY4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114944</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAY4"/>
    <dbReference type="HOGENOM" id="CLU_2775712_0_0_1"/>
    <dbReference type="OrthoDB" id="4074932at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="69" mass="8036" checksum="CFA0904E1A7535A7" modified="2011-11-16" version="1">MNRAFVRSFNKQPVNLIKSTTTNLARTPSSVKFRPMEFGNSFKTFKEYRLRAVNQSPLFKKNASKNDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB07</accession>
    <name>G3BB07_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Farnesyl pyrophosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_115573</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573</strain>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB07"/>
    <dbReference type="STRING" id="590646.G3BB07"/>
    <dbReference type="GeneID" id="18247921"/>
    <dbReference type="KEGG" id="cten:18247921"/>
    <dbReference type="eggNOG" id="KOG0711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028376_1_0_1"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV62778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="347" mass="40023" checksum="DF46CDD038C4C026" modified="2011-11-16" version="1">MSSKEQFIKVFDELVVELRQILTDYKMPAEAIEWYERSLNYNTPGGKLNRGLSVVDTYCILTNQKVTDLDVETYKKVAVLGWCIELLQGFFLVSDDIMDQSKTRRGQPCWYLVEGIGNIAINDSFMLEGAIYVLLKKYFKKDSYYVDLLELFHDVTFQTELGQLLDLTTADEEVVDLDKFSLEKHSFIVIFKTAYYSFYLPVALAMFVAGISDEKDLKQAEDILVPLGEYFQIQDDYLDCFGTPEQIGKIGTDIKDNKCSWVVNQALKLVTPEQRQVLEENYGRKDDVKEAKCKQLFNDLGIEAIYQEYEESIVGELKGKIEAINESSGLKKQVFYTFLNKIYKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB74</accession>
    <name>G3BB74_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_124262</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687674.1">
        <property type="nucleotide sequence ID" value="XM_006687611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB74"/>
    <dbReference type="STRING" id="590646.G3BB74"/>
    <dbReference type="GeneID" id="18249015"/>
    <dbReference type="KEGG" id="cten:18249015"/>
    <dbReference type="eggNOG" id="KOG4852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044104_0_0_1"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="305" mass="34989" checksum="7D3093D7ACD59FE5" modified="2011-11-16" version="1">MEPPTILRIKRKRGQDPLQALILEERQSVKRSKPTSPVSSGAMTPIEEPANFYFKLTRTDNSHDLDDASVVASLLAETSASQTTRSFVIPKRQTEEDMVIPHELSDMVEDFMISNNSTTPQRRKRHTSVAPAPHSSVPDEDEYVYDVYQLATITDQNHPKSQIGYIKFFEDDDELNGSEDSVDQALYSDHEDSNAEDYYQNDYPEDEDADIGDDIHNDYGDTALDLEPDQVNELYDYVQVHNADLLDDGYVSADDEDYVFSEEEDDSESEEFSRQKFFDGESDDELAIHRDKIFDQLQRMINEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBD0</accession>
    <name>G3BBD0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115626</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688326.1">
        <property type="nucleotide sequence ID" value="XM_006688263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBD0"/>
    <dbReference type="STRING" id="590646.G3BBD0"/>
    <dbReference type="GeneID" id="18247940"/>
    <dbReference type="KEGG" id="cten:18247940"/>
    <dbReference type="eggNOG" id="ENOG502QU02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039436_0_0_1"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="53573" checksum="FE8A77BE569049B5" modified="2011-11-16" version="1">MFRLPSPRQLARFARSNPMKHFTPRQPFAFPPSAPRRFSRSFSYNYSQPFNPHHKRNRFLSVLAVFTVATGASYYLFWPHHTFPSSVAKILRKGLWAESDKGDKDYALALKHYIEALQECDKLELDRLSDEYTGIQLKMGEMYERLGMIDEANFLYNEISTMYLKVLTDKSVTLSDPRRYHLVQKDLRVVAKLVQLNRTNLGLCKAILITHAILPNIIIDNKLGQKLSQLSMADLDSPESAGRLQAVRYLPFLDEYINMMDMLIAINISLGDYSYSINVNLNLNKLMLLVKYAPDKVLLNQCNLGSLLYFQGGVFEAEMVSILKKHGLDIKHKRPDQYANGTEVPEEDRIKFNALHHNFAQCVALASEAYENVTKIANNLTRNVRMGQDSKDDEKEETAVAELVALATYSLGVIHLHLGNYSQSERFLRESRVKSKSCDYQDLLGEIESELGKLFAEKKRLQTNEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBM7</accession>
    <name>G3BBM7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Negative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115039</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688739.1">
        <property type="nucleotide sequence ID" value="XM_006688676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBM7"/>
    <dbReference type="STRING" id="590646.G3BBM7"/>
    <dbReference type="GeneID" id="90981617"/>
    <dbReference type="KEGG" id="cten:90981617"/>
    <dbReference type="eggNOG" id="ENOG502RCZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065853_0_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="208" mass="23895" checksum="F083F4AD0A6BC078" modified="2011-11-16" version="1">MYIPDKYDAPEWEQQKSIIKEYPLAVLITSTEDGIIANHIPFNLVERDGKKILQAHLAKVNHQLPSLKDNDKVCVVFSSSDAYVTPSYYKTKEETHKVVPTWLFAAVHCYGSSTLIDDFDFIKKQHESLTDQEEAGREKPWAIDEAPEKYYKIMQKAIIGLEIEITKIEGKFKFEQKMRREDIDGVITGLAQDNIPRVSKFVEDSNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBP8</accession>
    <name>G3BBP8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115666</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688376.1">
        <property type="nucleotide sequence ID" value="XM_006688313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBP8"/>
    <dbReference type="STRING" id="590646.G3BBP8"/>
    <dbReference type="GeneID" id="18247958"/>
    <dbReference type="KEGG" id="cten:18247958"/>
    <dbReference type="eggNOG" id="KOG2307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229791_0_0_1"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="225" mass="25637" checksum="D7A073BC7E4C7DD4" modified="2011-11-16" version="1">MSLDLDIDEFSNKNLRDLINEPSFDVDPFLHKNYRFESIDLLTKELAVLHSQLNQELIHLINNNFDQFIKLSLSLDGSAELINSISVDLNNFNLKLQAVIFKFNKVNGQFNQVLQFQTDLNRVKFKINAVLLTNKLISNLDGLLVLGSTGSPNPKQSVQLAKNMLNLSLNINNLQLITNHGLVNLKKFKSLLLELRSFLGSLKNLDSEDKFELFKVRKILDSINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBV0</accession>
    <name>G3BBV0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide:N-glycanase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116106</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBV0"/>
    <dbReference type="STRING" id="590646.G3BBV0"/>
    <dbReference type="GeneID" id="18248169"/>
    <dbReference type="KEGG" id="cten:18248169"/>
    <dbReference type="eggNOG" id="KOG0909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031058_0_1_1"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="6">
        <location>
            <begin position="175"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="368" mass="42155" checksum="EAE84028B7115649" modified="2011-11-16" version="1">MSHYSQVKHKLIDTYSQRCLQKLSDTTRTKGPIVQARLSPKDRRFVSQLIGLVSQVEHYRNPVHLDKALDAVDLAKIYEGVDKREQQKPQAPDSSLQYEDLVVLELLHYFKNHFFKWITKPECPRCTKDGDNIVPQGVTGPPSQNPDGISRVEKYRCRTCSVAIEFPRYNSAVKLLETRQGRCGEWVNCFMLISQAVLGPEAQMRYVWNNEDHVWCEYYSSGLKRWVHLDPCEAAFDEPSLYTDNWGKAMSWVVGVNHSYMVDLSHKYITNSNKTIDKSRVVDNVWAVESTIRLMAFQMLLKYYQLNIEPLSVSKAEKLSLFYYKCLVVYGSELNKSPTSTKSAVTRTATTGRQTGGPEWTTARGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBW3</accession>
    <name>G3BBW3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_126965</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBW3"/>
    <dbReference type="STRING" id="590646.G3BBW3"/>
    <dbReference type="eggNOG" id="KOG2575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008110_2_1_1"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="542" mass="62314" checksum="AB02F32F1237F5C4" modified="2011-11-16" version="1">MAKKKSSTKYKPKPVNVVSKSPVAKPSPFVDAPVFELLHNFQKAPDQWAARYIIIITAIIIRSAVGLGSFSGFQENPINGDFEAQRHWMEITTHLPINQWYFFDLQYWGLDYPPLTAYHSYLFGKLGTMLNSKWFELGTSRGLETVDLKNYMRFTSLISELVILSPALLGFITFIGKKLNLRRIDQILITCIVMCQPALILIDHGHFQYNSVMLGFFLYSLVDLLKGNFTLSSIWFISAIFFKQMALYYAPFIFFFILSKFVVNLITKFNFAKLFSVGLTVLVTVLTLLSPLMLGGWNDMVTNLKQILVRVFPFNRGLFEDKVANFWCTTNLVVKYKQLFSNDQLTKISLVFTLMSIAPPCLMVSYKNLMGSKFSKSSTSTSKYMSLVYGFAATAWGFFLFSFQVHEKTVLVPLIPSTLLYCLNTSYYISITQWINNVATFSMFPLLKKDGLSLQYAVLLVMINWLIGGFNWRGNLLFQKSSWFWNSVFALSYLSIAAYHIIDFQFDPPASYPDLWVILNTTISFGCFSLYYLWLNYEIYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBW4</accession>
    <name>G3BBW4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_116116</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBW4"/>
    <dbReference type="STRING" id="590646.G3BBW4"/>
    <dbReference type="eggNOG" id="ENOG502QTKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011476_1_0_1"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV60096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="226" mass="26361" checksum="B689E1DE83F98363" modified="2011-11-16" version="1">MTLSMGVWIGEDDKINTQQLEIMKKVLTKYPRKMFDSVFVGNEVLFRQDKTTNELIEIIQDVKHFVKKIGYFDLPVGTSEIGSLIDGRLLQACDIVGANIHPFFGGIDVSMATDWTYDFLKYQIEPINKSHKTKLVITEVGWPYRGGRYEGSVANATNFQYFMNAWLCESQKYDIDYYFFEAFDEPWKKIFYEDGNTWETEWGIFTSDRQMKPGVQFPKCSKNHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBY2</accession>
    <name>G3BBY2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116127</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689326.1">
        <property type="nucleotide sequence ID" value="XM_006689263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBY2"/>
    <dbReference type="STRING" id="590646.G3BBY2"/>
    <dbReference type="GeneID" id="18248181"/>
    <dbReference type="KEGG" id="cten:18248181"/>
    <dbReference type="eggNOG" id="KOG2823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035888_1_1_1"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="385" mass="44198" checksum="58D4648A6EAB1CA3" modified="2011-11-16" version="1">MGSKTSRKTKRSWVKNIDIKDIEDNLEQSREKQRLVGTDAEFVIDETPSDVPSAKAAKKLKSTEILTNKSKIPALEVERNKKPSGRTITRLMKISGRIDGSTSMALVNKDGLLNVKNEDLWNEPPAAPAPVRDVYPMNLPPAKSKAKKVRPSTIDEAPITLEFEDSELHGGKSYNPSLESWKQLVNQEFGLEKIKELNRQQLIERQEMLARMLAEHESSDEEEESDHEINDPNHANDTNDFKLSANKPTELKRKTKTKRGRMLKHKKRVELEARLKDLKHQIHQIGQLDLEELQHRDTKVVDKVTKKKKAAKRLFKYNLMDAPLEVKLSDELSSNMKNIKAEGNLFYSSMINLQKKGLIEARVPVAKRSKYKPKITEKWTYKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC58</accession>
    <name>G3BC58_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_95589</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC58"/>
    <dbReference type="STRING" id="590646.G3BC58"/>
    <dbReference type="GeneID" id="18250519"/>
    <dbReference type="KEGG" id="cten:18250519"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006468_0_0_1"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="245"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="430" mass="48441" checksum="CBEBC879DEFFD483" modified="2011-11-16" version="1">MSVFNTIFGSAKHDKAIDGLFGSAAPVDRTRLVRERTVPDSRPQNVSPEDITQTQTSSPQDDNLPQTQSQPRKKSTRDENFDLEARYFDKLLKEDKPDVQPVPSVEESSDDSDSEETKPAKRAKVVDLKETELEKAEKTVFVGNVPISVVTSKPTYKRFKHLFANVGPVQSIRFRSISFDQALPRKIAFAQKSFHANRQNINSYVVFETKEASLKAVDLLNATVFDQFHLKVDHVTHPTAKDNKRTVFVGNLDFDEQEETLWKYFNAHTANDVESVRIVRDAKTNLGKGFALVQFNDSLSVNKVLMLHDKPIGGGSKRKLRISRAKNHAKPSELSPNHIDNQKQNKNKKGLRSLNDKQKTTLGRVKVLGKADKATAGDVKMVMEGERAHKRGLLKNGQLKVKKPRHKKPRIRDRSTRFKEQLKAGAGGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCY0</accession>
    <name>G3BCY0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_95690</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689449.1">
        <property type="nucleotide sequence ID" value="XM_006689386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCY0"/>
    <dbReference type="STRING" id="590646.G3BCY0"/>
    <dbReference type="GeneID" id="18250529"/>
    <dbReference type="KEGG" id="cten:18250529"/>
    <dbReference type="eggNOG" id="ENOG502S7ZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060554_0_0_1"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089713">
        <property type="term" value="C:Cbf1-Met4-Met28 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="328" mass="35504" checksum="ACB872D6AF186216" modified="2011-11-16" version="1">MADDQDKTNKAILDQLVYIDNFIGEDHELNFDLSAFADDSFIFADEEKPPNDKINEMLRNKEGLHALSHGSASGEAAGHGDLGGLELNNLPRFPVPPGAKSSLEQAGLNQSQIDLLSALIAQYQSVQQAPSLDSVDPVDPQMVGMSAQPPRPRHNHRHSQSHTSRLPLLRTTSHGPGSASGSSSAGGGLGLSGDTAAPETFVPFFSTSPSLATGSFGDSAGTGTHDDGSGSESPASSSTSKSIDNDIDKRRRNTAASARFRIKKKLKEKQMEDKISNLQDVIRGFEGKIQTLELENRLLKNLIIEKGSEKSDNELRMLREKIYREEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD99</accession>
    <name>G3BD99_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_95730</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689491.1">
        <property type="nucleotide sequence ID" value="XM_006689428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD99"/>
    <dbReference type="STRING" id="590646.G3BD99"/>
    <dbReference type="GeneID" id="18250534"/>
    <dbReference type="KEGG" id="cten:18250534"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018538_0_0_1"/>
    <dbReference type="OrthoDB" id="4090081at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617:SF173">
        <property type="entry name" value="RE54577P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="767" mass="86755" checksum="B5E43474CEB1B02B" modified="2011-11-16" version="1">MEYHKISTLPGEVIEHILSYLDISEVSFLANQIRNLSEKPTASLSNLTNQVLRYIAHCNICYTNRLSNYTILGLYILTPSYISKKDLDLVKSQESLLSMMRFCKWAGDQLTNEVTLTYYVKELSDLVDFRDVVYELGRDFQSMNFTFNIELEFDPAMLAVMDLSYIISMFKTSNFGRFITSMLITNYVPYCLIDYHDFPNLKRIWLVNSNLHAMDDSYLTQTKITDSFMCPDPFGNINNMSIVLKTGLPSTLTTLTLNHVTISREVLKYQYPSKLVKLDLESVKDLSHGKFFCGLLKANVNSKVLKDLRLQKLDGLTPENNQELHILIQKCCPVLNNLSVSPDQYPTTGSDVQSLVYLSNLKSIDISKPFVMTNFADVFKSLVSLRLENCDIDSLGELIFPPFLESLDLSYNPIEWSYPIAFPPRLTTLELRNTGLRKLNYLVLPRGLTILSLEVNLLTTIDDFKFPPRLRSLGIGSNRINKIQNHYLPPTLAILHLTENFVSNPVNFEVNARGEKLNIFSLYLNHNSIQDLTGFTFGSSLKVLNLDGNNISTLKNIDFKDLIELSVCGCNMNSIRNSKFGTSLSILNMGNNNLRTLPQGLPVSLKTLDLSFNEISTIDFDAFAHLSGVDRLSVSHNSLRQVKLRLHPNLRFVDFSCNKIVSFHLSYDKSLLTNNTTSLTSVNLSSNRLSKFSPDNLGITEVIQHNVLFEIDVSANKINSNQLDPNKFPPSMNALFVGYTGRQDAFGYDIAGNLINCEFCSGKKVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDI5</accession>
    <name>G3BDI5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTEDRAFT_95758</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDI5"/>
    <dbReference type="STRING" id="590646.G3BDI5"/>
    <dbReference type="GeneID" id="18250538"/>
    <dbReference type="KEGG" id="cten:18250538"/>
    <dbReference type="eggNOG" id="KOG1131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011312_1_0_1"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="266"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV60308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="797" mass="91519" checksum="98972E5FABF2E57C" modified="2011-11-16" version="1">MKFYIDDLPVLFPYPKIYPEQYAYMCDIKKTLDVGGNCILEMPSGTGKTVSLLSLTVAYQMHYPEHRKVVYCSRTMSEIEKALIELYNLMEYRANELGFVEDFRGLGLTSRKNLCLHPTISKERKGAVVDEKCRRITNGQLKHRIEEGAIDEEAQRSNPEVNSLCKFHENLYDYEQHDLIPPGVYSFESLMDFGREKSTCPYFTVRRMIPFCNIIIYSYHYLLDPKIAERVSKELSKDSIIIFDEAHNIDNVCIESLSLDLTDDTLKRATRGANKLSDAIEDMKAQDSEKLQNEYEKLVEGLRQAEIARDEELFMANPTLPQDLLDEAIPGNIRKGEHFVSFLKRFIEYLKTRMKVLHVISETPNSFLQHLKELTFIDRKPLRFCSERLSLLVRTLELNDIEDFTALKDIATFATLVSTYDKGFQLILEPFETEGATVPNPILRFTCLDASIAMKPVFDRFSSVIITSGTISPLDMYPKMLNFETVIQRSYTMTLDRRSFLPMIVTKGSDQVSISSRFEIRNDPSVVRNYGSLLIEFSKITPDGMVVFFPSYLYMESIISMWQTMGVLDEVWKYKLILVETPDAQETSLALDTYRKACNSGRGAVLLSVARGKVSEGIDFDHHYGRTVLMIGIPFQYTESRILKARLEFLRENNQIRENDFLSFDAMRHAAQCLGRVLRGKDDYGIMVLADRRFARKRSQLPKWIAQALNDSDLNLSTDMALANAKKFLRTLAQPTNPKDQEGVSVWDLQQLQKHQQEQIKQLNEHSGNTGVSEDGVVSAPEDVDFMDMDDEELNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDQ2</accession>
    <name>G3BDQ2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116405</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689569.1">
        <property type="nucleotide sequence ID" value="XM_006689506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDQ2"/>
    <dbReference type="STRING" id="590646.G3BDQ2"/>
    <dbReference type="GeneID" id="18248288"/>
    <dbReference type="KEGG" id="cten:18248288"/>
    <dbReference type="eggNOG" id="ENOG502S0ZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042296_0_0_1"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="459" mass="53049" checksum="D1853867F56DEB3C" modified="2011-11-16" version="1">MVDYPIPGYPVVNYTATDGIMELLRYQQNYPALGTGQQVLATQARNLLGTIPQVFVEYQTKYQFNLFGDYPFKKDIVPSAVFVGVYGILLILHLLIFILNMSRGHYFWITLTYIFYCACKIVGFACRIVWQRDLSITAIGLTSEVLLIIPTIILVSFNLILAQRIFTWRHPVGGSRKLFWGIMFGFYGFVLGIVAMTIMASFVPYLHMLSQANYEKYIKVQQAAAILVVLYPFTAVSLIGLSYFFKPTRKDENLYTYQPYWIESFHPFYFVKKNASKEAEETFMKRNHNHRHAVRVIAATHHHYNMVQGLTNERGDLTHNMSLIIVSISTFVLFVGSLCRCIVVFQANYQKDSSAICSPIAMYIIWGAAEALVVLMYAVGRVDLRFYRPDRLPKKVRAIITAEQSIEQSEEELSDEEFDDDVRTSDLSELSFNNYKLPSYEDQFRREHEKEDNQSEFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDU6</accession>
    <name>G3BDU6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_110942</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDU6"/>
    <dbReference type="GeneID" id="18246235"/>
    <dbReference type="KEGG" id="cten:18246235"/>
    <dbReference type="eggNOG" id="ENOG502QTNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_3_0_1"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="435" mass="48491" checksum="DE0C738771169013" modified="2011-11-16" version="1">MINRVSIKIRNTAEKYVSGGVVKQISFGISLLSCLLLGSVLIFSLVAENLILELDFKIFHVNLISSFTVIGMYLCLPILGYLSDVYGNNLLSFIAIFTLVPSYILNYFAVFQFSNKLAWFCFTYCLIGLGTSSLYFSSLLTCSKIYPEKKGLSISLPVTSYGVSALISTQILKLSYFQQNHHLDLLRVFKFFAILYLVMGVLNFMATSIIIERTHKIDENTELIPISSIEPPSHKAKFIRFLKSPSMYILLGSLFLNLGPLETYQNNLNSIAWEINRKGSGSIDLNSQIILLSIFSTITRLVVGVMSDHMNKRDILIGLLALGSINQAISWMKLTPDTMNFITVIDGITYGGVFTIYPTIIAEIWGIEMLGSTWGLFMIAPAISTSLFSLVYGSLLDNFGDLVVYFKICFFSFVTSTALVVCIRNVKPVGHHIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEH4</accession>
    <name>G3BEH4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_137024</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60544.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
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    </dbReference>
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        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="238"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="331"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="335"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="453" mass="52786" checksum="4C8F01FEE5B7928B" modified="2011-11-16" version="1">MNSFRPDKHRKVLNDLTLNENTKSYERYDKKPKLFKDHVNTASTSSLLEDKEIEVDHTQIVSELETQLLPYSNEFHMDGPIHQYGENDPQQDDDDDIEGPDYVPEFDDDIDLSELEDIDDEAEDADEDENSNEPDQENIPPPADVGVSQADASFSKHVAMEPLWNKAIFGELEVIMKKYSSKTLDENDEDTYDVTMVAEYSPEIFNYLHQLEYKLVPDPNYMDKQDELKWEMRSVLIDWVVQVHSRFNLLPETLYLTVNYIDRFLSKRKVSLSRFQLVGAVALFIAAKYEEINCPTIQEVAYMADNAYSIDDFLKAERFMIDVLEFDMGWPGPMSFLRRTSKADDYDYETRTLAKYLLEITVMDSRFVASQPSWLAAGAHYLSRKLLNRGGWSELHVFYSGYTEDQLKPLAAVLLRICENAETNHKAIFDKYQERKYRRSSTFVQECLESMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEN6</accession>
    <name>G3BEN6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sin3 binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_126576</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEN6"/>
    <dbReference type="STRING" id="590646.G3BEN6"/>
    <dbReference type="eggNOG" id="ENOG502QW7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020170_0_0_1"/>
    <dbReference type="OrthoDB" id="5391991at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018818">
        <property type="entry name" value="Stb3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164:SF1">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10330">
        <property type="entry name" value="Stb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV59936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50804" checksum="44AD07D95D07C09C" modified="2011-11-16" version="1">MEPFENSSGSAPLKKHLLSTSSPEGIQIASKITATRLAELLIRKGPLPIRHITSQLALEVHGFDLLSLSKQRRLIMAAMEQTDAAHNVVFEKIGWGQWAVRKIDSDYIVTEGTEGNLFNKDAPEATSNDESVPVNPANKPHINVKDLRNQPNLKLGWTKKQSGKTSRRESITGKKPNLHNVKLPTDILSSSAIASDSDQDEEDEDDLIDAVIGDESSSDNDEESSSADESDSDELFQFDHDNTSKRSPPIKFANRVPLKLSPPPTTHPTRRKSSSSNSVNKNTNYNPRYQIFNRSRLNSLDNLDNYIISSAKNSNGSFSSPPPPPPNVAAAALSGSPLSSWNSNAYLSKSPDSLMMTKNGNRRRSSFNESHIRSTLSASVPRVASNGPSHKNSYPSTTTSNLTSNVNSPAMNPNTRNASSMSDTDEEDWATIGPESLRKRHDDKVQDEKETKAAAFALVDLMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BES0</accession>
    <name>G3BES0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_111661</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690417.1">
        <property type="nucleotide sequence ID" value="XM_006690354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BES0"/>
    <dbReference type="STRING" id="590646.G3BES0"/>
    <dbReference type="GeneID" id="18246304"/>
    <dbReference type="KEGG" id="cten:18246304"/>
    <dbReference type="eggNOG" id="ENOG502QWBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="196"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="339" mass="37331" checksum="82B8312EBC9C660C" modified="2011-11-16" version="1">MATKPEFLLIGPGGVGCIAAFTINYNHTANVSIVVRRDYETVRKHGYHIDSVDYGKVDGWKPENVFASVEEASKSGIKFDYIAVSTKNLQDIVPVEELIAPVVSAHSVVVLVQNGFGIEKPLFAKFPQNIVLSGVSHIGSHNRNGHIHQMQSDHLVISAFENPNVDADSQVAAANRFIEMYSNNINKCVYFASAKWYRYRKLVYNACLNTTCALTGVDTGRLEAAGGLEAIAIPAMKEVIRVAKADGVELPDDVINVVCHADDGDYFEPSMRVDVKKGNPIELEAILGNLLDTARKLKVETPILDLLFKLLTVVQFRLKEANGYVGVPEKRPIPDTFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEU2</accession>
    <name>G3BEU2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_137075</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689807.1">
        <property type="nucleotide sequence ID" value="XM_006689744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEU2"/>
    <dbReference type="GeneID" id="18250036"/>
    <dbReference type="KEGG" id="cten:18250036"/>
    <dbReference type="eggNOG" id="ENOG502RPWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068906_0_0_1"/>
    <dbReference type="OrthoDB" id="4018855at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442672" evidence="1">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="293" mass="32525" checksum="34F0CF88B0145DB3" modified="2011-11-16" version="1">MRFPRSLLLPICLAFVQAYPTQNTNNSSIVLSAQEQTELSPVIASLQQFNQELGFEKRHLFDKRSNIPVLDKVLTLLNDTNIANIVINHVLLSPTLLDLSTNATIFVLRLNLVNYDNLFIAIEKSGLVNQLILAALDNPNTLPGVLRLIDDLLKDNGINFSSLTSHKRQLDFETFAPVERRESKTLTKRESELLDELFTSLRDSGLVVSVVSNLLTNPDLAAPSAQFLTEILRSGAISVPEVLQALIESGALINILKDVLTDRAILEKVAQIVVDRISKGIIPKNLSDQIFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEU8</accession>
    <name>G3BEU8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_111241</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEU8"/>
    <dbReference type="STRING" id="590646.G3BEU8"/>
    <dbReference type="GeneID" id="18246259"/>
    <dbReference type="KEGG" id="cten:18246259"/>
    <dbReference type="eggNOG" id="ENOG502QQI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_0_1_1"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="550" mass="60785" checksum="763A0DD5FAAC13F0" modified="2011-11-16" version="1">MVPPVASIINFDHPSIKTPQDPVIDQLSLSDEVLIRHNAPAPTLYEDGLLEKGTLISSTGALMAYSGKKTGRSPKDKRIVDEETSSEHIWWGPVNKKVDELTWKISRSRALDYLRTREKLFVVDAYAGWDPRYRIKVRIICARAYHALFMTNMLIRPTEEELANFGEPDFTIYNAGQFPANVHTKGMTSATSVEINFKDMEMVILGTEYAGEMKKGIFTVMFYLMPIRHKVLTLHSSCNQGTETGDVTLFFGLSGTGKTTLSADPNRKLIGDDEHCWSDNGVFNIEGGCYAKCLDLSAEKEPEIFNSIKFGAILENAIYDPLTKVVDYNNASITENTRCAYPIEFIPSAKIPCLADTHPSNIILLTCDASGVLPPVSKLDNSQVMYHFISGYTSKMAGTEEGVTEPQATFSACFGQPFLVLHPMKYAQQLSDKISQHNANAWLLNTGWVGASAARGGKRCPLKYTRAILDAIHSGELNKVEYENFPTFNLKVPKSCPGVPAEILNPTNAWTEGEASFAKEVTGLATKFVENFKKYSDQATTEVKAAGPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEW5</accession>
    <name>G3BEW5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_128013</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEW5"/>
    <dbReference type="STRING" id="590646.G3BEW5"/>
    <dbReference type="GeneID" id="18249276"/>
    <dbReference type="KEGG" id="cten:18249276"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023312_0_1_1"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="320" mass="36280" checksum="D382CB77C81D1924" modified="2011-11-16" version="1">MIYRIIGNIYLSSFEGLADTDLQAHRISHVLSVVPGPLPKAIHSYTRLQLPINDDLTSNILAILPESFDFINNCLYNTTGSASISPRFPHKGAILIHCHEGLSRAPTVVVCYLIKFYKLSMKQAIYAIQRKLEDKININESFLKQIEVFESCKGDLTSDAYRDFLIEFNKGDSKEALNQFHTQNDSDSKQIEEEEPSGVLRCKICREILAKSTQILPHVKPDESSRHATFHKKMGNHIHSSFEASADCSHYFLKDPLKWMKLPKEELEGKFHCVKCQSKLGGYSWKGSRCSCGSWVIPSFHLSTSKVDYIKLAPVDKQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEW6</accession>
    <name>G3BEW6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116686</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEW6"/>
    <dbReference type="GeneID" id="90981790"/>
    <dbReference type="KEGG" id="cten:90981790"/>
    <dbReference type="eggNOG" id="ENOG502RQ1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1343081_0_0_1"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="204" mass="23068" checksum="D71D18329D5A2F15" modified="2011-11-16" version="1">MYSPSFNINSCYELWSEQKSEFYQSPLNAYPAEYPGISKYRQMSSLSLATQMKLNKLNSTKYYGYNSLKPIGINKTMEQIDHENNLVVETNVTNTLENDLVEQNLNVEVDLDNQVPNFDSDGDNNDVIDALNDEDEGFMAEEVEYQNDHSLGTSIVEPVNTVSPIRMPHESSSPTTGTINTPFPTLVMRAEQDNEEDMILDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFB8</accession>
    <name>G3BFB8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_110847</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFB8"/>
    <dbReference type="STRING" id="590646.G3BFB8"/>
    <dbReference type="GeneID" id="18246227"/>
    <dbReference type="KEGG" id="cten:18246227"/>
    <dbReference type="eggNOG" id="KOG3724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006103_0_0_1"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="847"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="84"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="12">
        <location>
            <begin position="620"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="897" mass="101493" checksum="6EE4DDB52AEF0015" modified="2011-11-16" version="1">MARCFKIPITLVGIVLWVALVSLYNYQLVGSDTPGCRPVRMGPSYARILGFDLSYTQYASKYSLYLYREQGKDLRPKASNNYRLDGTPVLFIPGNAGSYRQVRSIASKTSNIIADKQYDGFNSKHGKLDFFTADFNEDFTAFHGRTMLDQAEYLNEAIKFILSLYSQDEVPPKSVIIIGHSMGGIVARVLPTLPNYQEDSIKVMITLSSPHSKSPLTFDRDIMKVYRAVNEFWHEAYYGNSELSDVASARLRDVSILSITGGSSDMTLPADYTTMKGLVPDSNGFTVFSTGIPGVWTPIDHLAIVWCDQLRTVLSNALLDIMDVGSSEKVVGLDERMQLLKNRFLAGFEKADSDEVLSSVTLKLDKANVHQQASKSVIKTSVSVSSVFKIGANETFSLLSLEKPLDSCVYLCSDSIRPETIHDMTDESTSEFVSFSCHDYSSMVNMIPKSNDVESIKDSSIRDKTSPYYGLRLDPDVVNEYSHLVVTGLDSLVELKESPLVEVRPGWLGSSFKVPSGLRTTVRLKGVRSSLMSYDVSYKKLDFNPIIRQFINEETKWHIDNEFNLNFHGQAPYLPPVGEDLQLEVWTGHVGDQTPLTVHIKPNFLVRLKLLIIRYRITILSYGLIVNLLVFAFQLKEYEKTNKFPTYQKTLDKLLTSECLRDLVCILSVLIRSADVSSIVRKIIAFVHLEVTEVNGLGVSGSFFLHLMFLTLSVCINVLINLLVTSFLKSGGLIKLPKPNLKVKNIVLALMVLLTIVYLPYQVIYVVLTVTQLLKTLGLKNNNEINYNVIMFMMMIWILPINVPIIVVLVHNLTVNWKTSFSSHHNILSIVPIIYLVNYKNIIRLKYTNVIIVYLAYFMSYCFFYGSINTFWLYQLFNYMCILLIVVDNEWIHRDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFF9</accession>
    <name>G3BFF9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1237-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_96126</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689896.1">
        <property type="nucleotide sequence ID" value="XM_006689833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFF9"/>
    <dbReference type="STRING" id="590646.G3BFF9"/>
    <dbReference type="GeneID" id="18250582"/>
    <dbReference type="KEGG" id="cten:18250582"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023537_1_1_1"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="67420" checksum="3E3552DC05069C73" modified="2011-11-16" version="1">MAMYVYGKRIRPERLAVLVVAAVVFTVYLYVYSLPNILPEVVDDKKSSVVSLPRRQGIDNIDQQFLEYMDSKVTKCPDYTKYSELSHEPFSKGPLKYAYMRPAPKCRTFVSSAVEYVIDDLKKKLKDEDLGRLVENCLPNTLDTAILWHVPTGEKNTAKQVPTPQTFIVTGDIHAEWLRDSARQMSAYQPFVKYDTKLQELIKGAINTQSLYLWNSPYCNAFHPPTGSGIKKGNSAIDKVHPRPDWRHVFECKYELDSLASFLTLSNEYYANSGDMSFVNDAWLQAYNQILSVLRRESSPTFNQRTGSVLPFYYTFQRDTNIGTETLPLAGTGNPVNYGTGLIRSAFRPSDDACILQFFIPANMHMLTELKTLRTQILNEKLHVDSKLDINAMIATTDTVIKNVEIGINQHGIVDHPIFGKVYAYEVDGYGSSIFMDDANIPSLLAAPDMGYIELENKVYQNTRKMLLSKNGNPYYLKGRYFSGIGGPHIGINNAWPMSLLVAMRTTNDDEEILRDLKLVMESTAGLGLIHESVQVNSRGGNAYTRSWFAWGNSEFGKTILHLAKHKPHLIFKEEYHQPYDIDKVLQEFQAQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFG8</accession>
    <name>G3BFG8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116747</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689903.1">
        <property type="nucleotide sequence ID" value="XM_006689840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFG8"/>
    <dbReference type="GeneID" id="18248429"/>
    <dbReference type="KEGG" id="cten:18248429"/>
    <dbReference type="eggNOG" id="ENOG502SS03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1266754_0_0_1"/>
    <dbReference type="OrthoDB" id="3980365at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="223" mass="25808" checksum="54988AC896F243D6" modified="2011-11-16" version="1">MSIPKLTIPETAFDPSIYTSSHRRSRLLVYLLQLTNSSAILLVLIYVVSYIGIKPLLELTCSRRLEMLDKYRHKLRDLYLLLVSKVDHIPIVGFNRHGKVFSDAMIQTDASYARRLKQLSPADQLEELEKTDKLNHSKLLSKLRKLNDVLSGCTSYTISEMPHYKSTRETVKSFQHEIDTKIFDYDELYTVETNSEHRKKRNLVVDTKNDIRSIKGLFMSGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFV0</accession>
    <name>G3BFV0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_132427</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689950.1">
        <property type="nucleotide sequence ID" value="XM_006689887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFV0"/>
    <dbReference type="STRING" id="590646.G3BFV0"/>
    <dbReference type="GeneID" id="18249620"/>
    <dbReference type="KEGG" id="cten:18249620"/>
    <dbReference type="eggNOG" id="ENOG502REX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_380807_0_0_1"/>
    <dbReference type="OrthoDB" id="4035953at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014805">
        <property type="entry name" value="SKG6/TOS2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08693">
        <property type="entry name" value="SKG6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="755" mass="83416" checksum="4B70C12F05C08168" modified="2011-11-16" version="1">MHIQLIHHALALYTRSNNDNDDNCSGKNKHSAQCQKPENDNGLTVGLAVGLPVAAVLLMVSYFIIRNYRKNKKESMEHDPDFDENGEATVLPDFPIGAYGRPVEMEDPFDNRNSARFPPPAPKGANFHGGRSSSASFSGSTKGDAYVQSFVLPYQHQIGSKVSLDEYAKQLGEYGSVYAASPRGSAYLVPGGHTRAGSSNLSNFPVVQANGSGNKSTTVSPQKSSLKHETKPSVPEAAKSDLQYGSIAPEDGIEEVSDDSDSSIRGAGSPQFAINYENESDPHINNTLNQKLPSPVVRVDATHDTSNDSFNTTTDQFIPKEVPTINDTHPERIENNHSPFSDNAQVDTPPSVEPTVTEVEDEQIDGDFDFSNESADASAINTVGVGEQLTANTSASNLDVPGDAEGQKLADSERVDSGSRKSPRISAFNLLKNVSDDEDDGQEEHDEDKPLENDLSPDQEEELRRMKSVYRLYFDRANSVKRKDSVKSEHPEYEANYEFQADPDQPLPQVDMDQYLKINTKLRTDTDYNKRLTTTSSIYTDNGPEFVQRAPPQQQYNYYLQDQSFQQFYQEHVQSLPPLQSLPNPSDIRKSTIQTYTDYQPKSKNNPVTSPTMKQPFNPIESDNVWTSPASSPVTNNPPTFETDTYTKSLASAPSATQLSRSSVVMLNPVTEITKQRKFKPAGSLPSGHRNNHAYANAGYAQQGYPQQGYPQPGYPQQQPMHQQHSGQFTHEHSTDSLIPGGKKSDVRKMMNSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW00</accession>
    <name>G3AW00_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_117243</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW00"/>
    <dbReference type="STRING" id="590646.G3AW00"/>
    <dbReference type="eggNOG" id="KOG2375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009985_1_0_1"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="70"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="495" mass="55936" checksum="D77A051704F8B005" modified="2011-11-16" version="1">MKSQKLQKSTSSKAEVIESKFKTDADIANANFKERELEKWVPDADDTKVLTFDENSTGGWDQFRVNQEKFGIESTYDEHLYTTRINTEAKDFQERVKKAERLANEIENDGSIDPHILEERGKLKDTGLDEEMKYSGVLRDEDPDVTKRDTRGDELMAALKSVNISDKKYVPPKPNALNTAHKDPAIASIQKPSDKKHTEESFRLNAQSEINSLKEFSATFKVPHKLPNDLLPILAKDKIKQDEILKKSSTPTSTSASSTSPPPPAFKLNPKAAAFTPSSPRGQGSPKPQAPKLPYVNNGMSKRHYQISPADFFGGFDRVPTKESQIEKSKKIKISFNLFVTAKRNTPKGEPVTIERAYTTPPTWKQTVDEPYYNLFPSPDTINQSPQAKPQVLNQQAPGQHPQAMNVFQQQQYQAAMFYQQQLGMMPQAQGMPGMYVPTGGEFMMPGYMPPNMNYSGGSPNSPRMVMQYPYGNSNQHHQNYNGNHHRRYNQKRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW26</accession>
    <name>G3AW26_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sister chromatid cohesion protein PDS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_100752</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AW26"/>
    <dbReference type="GeneID" id="18245408"/>
    <dbReference type="KEGG" id="cten:18245408"/>
    <dbReference type="eggNOG" id="KOG1525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002562_1_0_1"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1231"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1248"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1267"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1284" mass="145912" checksum="B51495B9846CC164" modified="2011-11-16" version="1">MALSGETPPKSKLTFSKSIISTPQNPIATKDLVKRLQQLSEELSTIDQENPDLKSFDHIKQDLVNPKLLKSSNSGVQAYVCCALADILRVYAPDAPFTSVEISSIFKAFFNQFKKLSDTHNLYFQQQCYLLKRLAEVRSVVLIADVADSEQLIETAFNVFYDLSNKDFPHRLEPLICDILSEIMAEAEVLPHNVLKLVLDKLLTNNPNTSNITSSKKISNPGFKFSVSICEANADSMSRQIAQYFSEMLYETSQQMDHFKQDSTSKMINMKAIEALKRIHKLSIHIWCYVPGLLQSVMGLIEEELNADDETVRILATDAIGQMIGSSGSSQNFIINYRETWNLWLKKTLDVSSSVRCKWVEQVPMIINNASSLTSEVTTELCRGLNKCLLDSDEKVRLASCISIEKVPFESFTRIFNKDTMEILSQLIRERNSDIRKQAIVTLSNRCNQYFGSIVNNQVIDFGGKNKEESELEESSFKQIPNQLLSLIYIDDKDINSTLDVCLFEKLFPLSESTTQRVNRICQIFQNLNEKSMQAFEAINKRQQRSAEVMETFVKLCEDYAKIGTFADEKENVSESTKKQSNEERSILVNKLEKVAKWFSESISDGLNSFSCLERFFKLKNFRFLYLIRQAVSSNSDFLLVKNSIKELLTKLSNPKSIRVDEEKNAVSTTDMVSVFKLLLFRSSLIIYNKSNIVELLKFSKDSTHKWNPVSKDLLANVSETVPAVFTSHIIDLVDTIKDSETIPSTRAHNLKTLYHTVKKIPTAFPKDKEFGLLLEKLSIHGSPREAEFAIKLIGFSPKKVLLCAQVSEEILPLDIHSSLLPTHLAFLAGLLLVHAQVVEESISDISATLIKSILLSNGEITEDIVNDESFISDSILQENPSQYQSLVNKLLVLKIFTNRLKSLTEREVDEQQFVDTSKPIIKLFVMLVINGGEIVKEVPTPMAYRSRLRLEGGLSLLELARHSKFGESFGVDILNKLVLLVQDENRSVRSEFLKALQMYLSKDEINERFLNLVFFMNNEVDDDLSLTAQTWIKSMIKKSQSKKSIKFEKSLAILIHMLSHNPKFAQEQDTLKAYTFALEVLMFCLHNLLNSENISLLYYLASRVKQFRDATIEQSLYDIRPYPQKVNNVYCVAELCQLIIKEFSEHKNWPTLSWPGKLQLPKEFFTSLLSTSEAHAIITKVYISEELQIQLRGLIKQRLSSGNKKRPGKSNPLIKRIKTNNSKVRVVPKPKVPKALKSTKGGIEGNEPTRKSSRSRKEVNYGGLDSDSDLDMDMDESSDDNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW73</accession>
    <name>G3AW73_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_117366</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW73"/>
    <dbReference type="STRING" id="590646.G3AW73"/>
    <dbReference type="eggNOG" id="ENOG502QS9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012509_0_0_1"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF76">
        <property type="entry name" value="PROTEIN LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="612" mass="65748" checksum="221E929D5ACB0969" modified="2011-11-16" version="1">MDLAIELESPPAVLYGHETESTGSIVSGLLWINAQEVADVVSVTLSLVQTIHLSRPFLLSSPSVQSCKECNTRENVLARWDVVTARSSFAPGSHAYPFSHLLPGALPPSSKLGSKTSTSYIKYELVAEAVVYAAPVPVKVMLPLHITRSVLKGPDRNSLRVFPPTDVRASAVLPNVVYPKSTFPVELRLDNMNSKSGDRRWRMRKLAWRIEETCKVRAFCCPKHQSKLRTSEDAQRRSKVLTPKSKAGAHHSTIQTTVMLAPDTSVIEESGGRDPENSASGLNGAPAVAVDTEEVEQSAPTRAVENFDEDFGSRARGASESSHGPRVRGGSESSNAPSPSPASTPHTTPGSPDDLHLYVSETRTVSHGDLKSGWKSDFAATGKIDLVANINCMNVSTGLVKTTTRASSLDPGDLYDNLRHGANLSCDIDDPNEGIFVSHLLNIEVIVAEETIPVKKKRVKSSRDLTLEPTSSASSQTADEATSSSSPSQAMGTPTGAARVLRMQFKLNITERSGLGIAWDDEVPPTYEDVRTLSPPTYESSASATPQSRGLQPGSSELQPQSSDSSPLAEPPSAVLRTPGILYGIGSTPGMSIHVDSIDNMLVEDRIQDLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWF1</accession>
    <name>G3AWF1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112246</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWF1"/>
    <dbReference type="STRING" id="590646.G3AWF1"/>
    <dbReference type="GeneID" id="90981985"/>
    <dbReference type="KEGG" id="cten:90981985"/>
    <dbReference type="eggNOG" id="KOG3035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051989_0_3_1"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="255" mass="29130" checksum="A797871B69AF03D2" modified="2011-11-16" version="1">MAVYWDKFILFGDSITQHSFDQIRGFGLGAGLQSLYVRKLDVINRGFSGYNSEEARLMLPHILEAEMSGKSQVKLMTIFFGTNDGLNTFQGVPLGRYIENTKYMVEFAREKGVENVIIIGPALHDTPTFLNQNKDQGVGPVTSNSIYRKTNDHLTKLCKDLNVPFIDTWKVFQAASGYTELELLDEQYPNLLEFLFDGIHFSPSGYQLLFDEVCRVIDKWYPDFAADKLEMKFPNFTDVDMENLSESLFANVRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWL7</accession>
    <name>G3AWL7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_101118</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWL7"/>
    <dbReference type="STRING" id="590646.G3AWL7"/>
    <dbReference type="eggNOG" id="KOG2125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004770_0_0_1"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="842"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="13">
        <location>
            <begin position="400"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="868" mass="99417" checksum="EC234E7E127C929D" modified="2011-11-16" version="1">MKLSWFPVIVLLVINVGSFLLFLKGFFPSKRILDGFSDVSLLGSQRPMFDKVVVMVIDALRSDFLFSKSDSKFTFVHELIESNKAIPFTAFSNPPTVTLPRLKGITLGSTPNFLDAILNIADDKDKSQGLLNQDNWLHQFKYSSNSPKTINFYGDDTWLKLFPDFFNSTDGTNSFFVSDFYEVDNNVTRHLDNELASEANWDGLILHYLGLDHIGHKTGPDSKFMKLKQEEMDKIIERIYTFLSESSNHKNTLFLVMGDHGMNEIGNHGGSSSGETSAALLFVSPKFEQLKLNLKAPLPPNNDYNYYQKVNQIDIIPTLSLLLNIPIAKNNLGIIIRQFLDLFPSKLHHSILLHNCKQFLDLFHLNNRDHSLNSEFHGLSTTEDDYIFLRKVQDIMFETASNYNYSNLYLSLFGSFICTLAILAYFNYGFLSKTTLVFQTAMVLYSFHFHGSSLVEEEHHLWWLLNLGFLGYLFKIQNFELPANFLIVLTALRVIKAWSNTGQKFNNYYVLTNLLLENPPLLWFLVGLTYLVCGSLIYFQGSIRHCFNFSISSNSYDVSYLNNDVNNGITFVSLSILATMSFSFKLLQGYMDGYDIPEWLETFISWNLLSFDIREFDKSRISNLLVSLSNNCLAGVLLIIFFRIALKFLRGFKIGLITDLVNLLTLFLINQTKIELVPMFLIFFIIKHHFSKILLSYRENYTQLDQLVFIVSSFSFLISNLTFFSMGGTNSLATVDLSNAYNGIKSYQLEKVSALTFISNFSGPIFWSLSSIQLIFETNLVNFQIKNFASDLINLKGIKFKLLNLKLLTNLLFYSICCTNLIFACYNLRFHLFIWTVFSPKLLYFGVWFVLLNTFIELGVSGILLAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWM0</accession>
    <name>G3AWM0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_91737</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWM0"/>
    <dbReference type="HOGENOM" id="CLU_1562686_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="171" mass="19459" checksum="0FE1325365CB101A" modified="2011-11-16" version="1">MCSSCIPKGVKTFTSKFTVQESYDLASELQDNYKEMENFTLTSTKRLDIDFSDLKNTIPRKEAAANTPQQKILGKTGDPNDFMGYNETSRFYGNFSNSLLACKLQYSQTGIEIKGSGEQSLDFSQLFSVFSKAPEYEETKYNLPSGHQEMKQVASFEGELQRKWPYKSLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWV0</accession>
    <name>G3AWV0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112337</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWV0"/>
    <dbReference type="STRING" id="590646.G3AWV0"/>
    <dbReference type="GeneID" id="18246476"/>
    <dbReference type="KEGG" id="cten:18246476"/>
    <dbReference type="eggNOG" id="KOG3394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036515_0_0_1"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442614" description="Endoplasmic reticulum lectin" evidence="8">
        <location>
            <begin position="20"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="113"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="490" mass="56423" checksum="CE56BDF82830F7F7" modified="2011-11-16" version="1">MVSWTRITVFAFWVSLFQASDVEELKFRLKYNHKSANVDIDSWLLGNQPNTSYEMVNINNQDSNVVCFLPNLTDDSVIKQLSEDESKEIRPQRSDKELLRAVMSNFTSYLDTKRCTFTTGLNDGYWTYAYCFGDKVIQFHEDLTAFRESGQHKPENPDFVFVLGRFNGSQSHVPEVVNQGTPDSRVINIEDYEIINDPVVTAGYRSRSPKALRHVLRNGEICDLTQEPRTIEVIYRCAQSSDFKTSVFYVKEQRTCEYTMIVNVRGLCEVEEFAPFADEKVVDIICDVKNTSRGFGLAELAGNELVFPRPNSTQVDIQDFNLIPGGKGFFWGKPKHHGRSESLYDKRFVVFCDKDMRSFIETFPRVFSDSMEFKQESPFPSEDKDRVTWDDTFVAWYEVYNYSGEFLFVVKVARKNNLHTKEITIQLVDPFTMMDQDGDPVEVSIPVESRGLYHFEKFSKEIEQTKTLIVTMTVPGQFAAVTNVAQLNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX21</accession>
    <name>G3AX21_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_132924</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX21"/>
    <dbReference type="HOGENOM" id="CLU_1038273_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="268" mass="30807" checksum="CE6151E140422DA7" modified="2011-11-16" version="1">MSTTVCNESLPSSIACIVNDYTKTRGRIELIINSKTLYWALDVVKGIGAYSDSETPNIGWITNIFDGEDDDDYGTTYSKERYFSSERKKEVLMTEEIILSLRKRDDKNAKTTREAKIQKKRFDEILQCLRTRNDRGENEDKKDEKEIACIILEELKDYKAELINTQFEVLDDRIVCLVDNYTEVDGTIEFTINSRVLDWASAVASGTTFPDRPTSYWVMRSTIENREPYFGLESAPKYHSGQNSSLREVKKFLANGNHPPPYSNKKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX23</accession>
    <name>G3AX23_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_91840</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683928.1">
        <property type="nucleotide sequence ID" value="XM_006683865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX23"/>
    <dbReference type="STRING" id="590646.G3AX23"/>
    <dbReference type="GeneID" id="18250116"/>
    <dbReference type="KEGG" id="cten:18250116"/>
    <dbReference type="eggNOG" id="ENOG502RMS2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1524946_0_0_1"/>
    <dbReference type="OrthoDB" id="4020766at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20175" checksum="098ED9594D0154CA" modified="2011-11-16" version="1">MTKGCNWKLQFDSTLNQYYYLDTKTNTISFDCPAEVKRTKKQSLLRRLSFKSKKSNESLITATCSDALSKNSTNSTSSYTSQSSTSSTPSQPQPKQTPFFDDEYLLNNPTNFRNFAGTSLAQADGFHDDVSSIDSESVITYYSELNHDIYAEDYYSFDKEKERIELRLQFMKELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXB5</accession>
    <name>G3AXB5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_91501</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXB5"/>
    <dbReference type="eggNOG" id="ENOG502RQC5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077173_0_0_1"/>
    <dbReference type="OrthoDB" id="4014468at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="210" mass="23680" checksum="77BCEE2B13F033F3" modified="2011-11-16" version="1">MRHAQLREILEGHGNDYEDVLSRRTDLVQQVIGQAFPLEPKEAIVILCGLSHAELAKDGTPDSMQKVVYDSEKLRQIGKGVYTVTKDTLLVFGDHQYLSTPTPELEYIITQIRDDRSIIPQYMKNCLLYESVIPFTGSMRAGSLEPEKAKERKAKIQDVSAIGSFFTMIGILTIKFGKEKVVEELLVPKVFNGKSGIIEIITERIGNRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXE5</accession>
    <name>G3AXE5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112104</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXE5"/>
    <dbReference type="STRING" id="590646.G3AXE5"/>
    <dbReference type="eggNOG" id="KOG1968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013192_0_0_1"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="895" mass="102508" checksum="13B69DE15EEB8144" modified="2011-11-16" version="1">MQKGTIDSLLRRPNVVGSEHFIGDIKSSQSTPDADSSPQIIYEGELQEDTLTDIDLSSTNPQSECQQDTLEIPDFHEVGEVLPSISLSVPPTFTSTTKLQASMDLSSYLNGNRRPKETNTESDQEIQTINRGNHINDLEKRMFRPERKSVNVKDFLSGSKPAAKSKSVAPDIEVIDEIEAKIFENQRKVTAKDLLSVRSKTPRPSMYVTLNVDKEALAFYKRFENSLKSRGTSVFVRKPKYEVTLKIPGHRLQHFESRIEELQEFHEKKKNVNSVFSMMMRESASAAVRLTPLQKLKELDPPVIKASDFHVFDLAEDNLPLHSDFLAGLKPRRSHFHNIEDSYQFTLENDSTSINYSHTPYSISFCQATQHLEKACPQEDPVFAALHKNPFDFDAVESQNWPQLFEPSSTSALLLPDDTKTRLQIWLHNSFGRLKTQSFKGSRRLKKRKVKKDDEMAGFIVDSPFEYEEETDEEVFMPLLVVHGDTGTGKSASIYAAMKEMNGYIHEINAGQARARKNILGMLKELCTTQLVHEHDQDGDFQKGIVLLEDCDILFEQDRTFWIVVQEILEISRRPMVITCTDPSVIPRALYEYAYEENAVLSFDKGRQALNDTYKKYLWGCCFSRGYDLDSLVIENLITNPGISKNMDVRQALLACQMICHNQIKPNYKGDEMNIIRITLNQTREVKPQVHTLEHIASSLDLLSIADLTETNVASQLNHDTIENEFIDIYYIDESKRLKQALLPHEQRIITELQTKALDAYPTNSDFDSYHTHNAIRRYVNDFVSSRSRPVPPLLRGLQMSREGPRTTRSNNGSERYEFWDPEPVGIPDGSVSLVLSPTPFTLEFAPFARYWCTFQAGLDKCDKQTELRTKMFIQWREFQNKSTRPLRTAPYIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXF8</accession>
    <name>G3AXF8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_100688</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXF8"/>
    <dbReference type="STRING" id="590646.G3AXF8"/>
    <dbReference type="GeneID" id="18245403"/>
    <dbReference type="KEGG" id="cten:18245403"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028982_1_0_1"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="107"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="4">
        <location>
            <begin position="240"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="525" mass="60655" checksum="9058541BA2B9967B" modified="2011-11-16" version="1">MASAIPYDPNEFEDNNPFAEPEVHHVTPAVQPGPQVSDEPIPEEPHSQRSTTPDQQGKLTEEELHKLLPERFSSKYKLKIALINIEKNKPGNPILKFNAEVQNLPRYRQAKYKEIRRTYQEIVKFNKYLTVSNLECFVPQIPSVQTSYPTGGEEETKQLMILWQEWFDRITRNPIIIRDEEFVYFLENDFGYSVINSNRKVSIASGLVRKTLKQLAVPYDAYEELVEFRPLIKAAYLSCQKLEKLLEKNSKMEKQHAASIGDLSQKLANLSQVEFIHPGMKNMWEKLSKIKLIEADLILIQSYNEMGTLGDGLRIFVEDFYQVKEALTNRHLIMRELVQAQQQTKIKHLHANKMKSKSALDPIKVDEALRSLEFATKAEESLTLQVKRISGEMIFEKDEVLQHTELKFHKLLKNYTLNRVDHHRKILKHLENIRLDIRIVDDKGGLSRLNRENLSNLKHNLLQSQSASGDSWSSRTFRSLSEEQDLKQKKEQEKNEAAETEGKESEIDNVVDAKNAAHLLGVATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXG7</accession>
    <name>G3AXG7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_132629</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXG7"/>
    <dbReference type="STRING" id="590646.G3AXG7"/>
    <dbReference type="GeneID" id="18249635"/>
    <dbReference type="KEGG" id="cten:18249635"/>
    <dbReference type="eggNOG" id="ENOG502RXKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035838_0_0_1"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="50399" checksum="CBFE93ACD9EEC800" modified="2011-11-16" version="1">MEDVIIARIPDAATYNLKNLSTWLEKLKQSSPLEAQVTRTVLSKCEGSNETEIIIDFMFSFMIILSTNEHLQDSPLADIDLYLELLSSTNIDTLDTKYYSKETDRDFLCEVEVSKKEALHQKYNAIAEAVQELGFMVPSFDEYFHMSKVIKSRVLEIPHPVEENEQDFVVNTALVPLLDFANHQEKSNAFFDVDKATGDVVLKYSAPPGLHEVCIQYSDVNYVQQFVTLYSFIPRGKVEVFEIKVDSDKINECINKVQNTQNVRYDLIMKWLEILPTVQFIIIDDRVGINHNHNPIPFWAIFSDKFKYVGWKGKVNIHSVNDPDVLVSGSSDESIEHMIEFQEERCDVIQGFEKVAVEPPQINAENEEAAKEKFTVFIKMVCRDLCNTADKIGLTKEYLEYKNRLFEKVLQMDDFNIQYVPVIDSWYQPNVIYNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXL0</accession>
    <name>G3AXL0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacid aminotransferase-like PLP-dependent enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_101096</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXL0"/>
    <dbReference type="STRING" id="590646.G3AXL0"/>
    <dbReference type="GeneID" id="18245436"/>
    <dbReference type="KEGG" id="cten:18245436"/>
    <dbReference type="eggNOG" id="ENOG502QQMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_6_0_1"/>
    <dbReference type="OrthoDB" id="5288718at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32159" checksum="33438B4B0469E48C" modified="2011-11-16" version="1">MARTKSEDNVSKLTTEECKQSGRELYQKYIQQNQEVTDFQIVSTIRYDPNISKVKPKAVDDITAENFFLLPEHINRLQFTIEFFTRNEETTLVFEEKTILDQLVTSIKDNSHPVDTPLRIRLLVGLDGQVTLEFFETIERPNLLRGLDDDIPEDEIWDIYVDSETILMSPFTSFKTTHRSHYNAAREKCLPGARVGKEEVILGNVRGELMEGSITNIAVHKDGKWVTPELSSGCLCGVTRSFLLMNMYIKEGKLELKDVNIGDEVLLFNGVAGVVRGQVKAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY45</accession>
    <name>G3AY45_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_101350</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AY45"/>
    <dbReference type="GeneID" id="18245461"/>
    <dbReference type="KEGG" id="cten:18245461"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005285">
        <property type="entry name" value="Drug-R_PDR/CDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00956">
        <property type="entry name" value="3a01205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1163"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1194"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1238"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1284"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1318"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1434"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="138"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="825"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1467" mass="165983" checksum="03991470CDD3C6E1" modified="2011-11-16" version="1">MESIHSQKDLTPIYEGFTTGVEAEIQQLARQVSKHSSIATDNSGDLGLTRTLTSLSEVPGVNPFVDDIDPRLDPNSNSFDSKFWVKNLRKLTESDSEYYKPSQVGVAFKDLRCFGVAMDADYQSNFLNGVYKSITQTIQKNTRNHQQGSYDILKPMDGLIRPGELTVVLGRPGAGCSTFLKTVAVQTYGFNVAPESQISYDGISASDMNKHYAGEIVYCAETENHFAHLTVGDTLKFAAIMRTPRNRPLGVSRDQYAQHMADVVLATYGLLHTKNSRVGNDFIRGISGGERKRVSIAEAALSQSKVQCWDNSTRGLDSATALEFVRALQTSARVQKVTPLIAIYQCSQDAYDCFDKVLLLYEGYEIYFGSARAAKQYFLDMGFECPPRQTTADYLTSLTNPHERVTKAGFEGKVPVTPEDFYQYWRRSSTRAQLLTEIDAYLEETSGHRADFDTMHRARQSKASRPGSPYTVSFGMQVKYITQRNYLRFLGDPSITLFMIISHIIMSLVVSSVFYNLPFDTSSFYYRTAVLFFATLFNAFSSMLEIFSLYEARPVVEKHKTYALYHPAADALASIFFELPEKLLSGISFNLIIYFMCNLKREPGAFFFFLLTGFGATLTMSHVFRTLGASTKTLYQAMNPAGLILLILVIYSGFVIPYPNMLGWSRWIKYLNPISYTFEAMIANEFHGREFPCVSFIPSGSGYPSNGTSIACSVVGSELGSSFVNGDVYIDTAFTYRWGHAWRNFGINVGFMLFFLFTYIILCEFNKGARQKGEILLFQRSKLARLKKVVVDEESGSTEKVHDNDVSNSDDSSEEKHIEKHENIFHWRQLNYEITIKKDTRTILTDIDGWVKPGQVTALMGASGAGKTTLLNALSERLTIGKITNGKRMVNGHMLDSSFQRSIGYVQQQDLHLETATVRESLTFSAYLRQPESVSKEEKDRYVDYTIKLLEMEKYADAVVGVTGEGLNVEQRKRLTIGVELVAKPKLLVFLDEPTSGLDSQTAWSICKLIRKLADEGQAILCTIHQPSAILLKEFDRLLFLQAGGQTVYFGDLGDECNTLINYFEKYGASKCPPNANPAEWMLEVVGAAPGSHANQDYYQVWKNSTEYQDVQKELDYMEQELSQLPKDESKESFKSYALPIYKQYWIVTKRVLQQYWRTNSYLYSKFTMVIATSLLNGFSFFKANNTLQGLQNQMFSVFMMLTLFQNLVLQYLPIFVKQRDLYEVRERPSKTFSWFTFILSQITAEVPWAIAAGTVEFFCWYYPVGFYSNAIPTKAVNARSGFMWWLVVLFFVYSSSMAQAVISFMETADNAGNLGMVLFSFCLLFCGVLSTSAHMPGFWIFMYRVNPFTYFVSAALSTALAKSTVACSDAELTRFLPPTNYTCEQYMEGYMAVAKGYLVNPVSTGECQYCKMSSTDAYLEQISANFDTRFRDMGIFIAFIFINYIITICLYWLARVPKRSKHRKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY76</accession>
    <name>G3AY76_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">INSIG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112654</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY76"/>
    <dbReference type="STRING" id="590646.G3AY76"/>
    <dbReference type="GeneID" id="18246621"/>
    <dbReference type="KEGG" id="cten:18246621"/>
    <dbReference type="eggNOG" id="KOG4363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088332_0_0_1"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36269" checksum="8E8BF6277B22D3E4" modified="2011-11-16" version="1">MSSNPIQLKKSILSNGTLKDVPDSRLSTRASSPIEKTDSVINLTKPSLYSIYNENAATALNLDDDEDDSSNQLYVQSTRVEEVYVPDHLSKGSKPVVAIKFILKAAVLSVCAYTYNEITRHIRNNHIKLGAQTFQPLFLTELFLTKSFHAVEPLKVLSKNFTPSQNYATVLVFQGMIMGLVHPFLDFVIPPKHNRRLFSSNPDPKKRYEPATLFNDILRSLITFLGISYAIRNLEWSSSLQVSVVWSLLSPCLWLLLDGTVAGLLAGLVVTVWGCLFVYSMNSDLINIYTSFESSDFIAIWLWTSSFFFCGMIIFGKIGRALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY88</accession>
    <name>G3AY88_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_102391</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY88"/>
    <dbReference type="STRING" id="590646.G3AY88"/>
    <dbReference type="GeneID" id="18245549"/>
    <dbReference type="KEGG" id="cten:18245549"/>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_3_2_1"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="116" mass="13145" checksum="F4FB2420D1B55F36" modified="2011-11-16" version="1">MSTFKKFADQVFSKQTFRYLFTTHFWGPVSNFGVPVAALLDLKKDPDLISGPMTGSLIVYSIAFMRYSMAVSPKNYLLFGCHAVNEVAQLAQGFRWANHHYFSEDKKLEDVSPKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY90</accession>
    <name>G3AY90_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SLD3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_92129</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY90"/>
    <dbReference type="STRING" id="590646.G3AY90"/>
    <dbReference type="GeneID" id="18250160"/>
    <dbReference type="KEGG" id="cten:18250160"/>
    <dbReference type="eggNOG" id="ENOG502RE09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_380872_0_0_1"/>
    <dbReference type="OrthoDB" id="5395343at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="234"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="615" mass="69556" checksum="69EA903719B04D16" modified="2011-11-16" version="1">MISIDVLNTLHSVNLGVLSERFHDTLMVLNVSNQVKNELESDKYFSVKFGHTLGGSYIPKEGIMFNIFGSFFGILEINSNKPKSAFHLWANSDSEFHPIEPDTAAQDIELSTINFSMKPPVTLSTTIKPTVISPEQISDPISYIKSRYYSILYSTSIPLSYFPKTAISRLKVLSQNKINLKDHICQIRLTVDQLNARHDGKFGVLKSLDNSTDCLDKQFEISHQADFVTSHNLIQSTESLNNDILQLKLRESQLQIIVLLELILAMELVESNFLYDNHPVLSETQKKVTRRRLIRRKNQPRKIIPTFLGMGVGVSSVETQPDGQKQESDGFSMHSLLHTLDSLIERLRLLDTLYTQKNNTLINFVAYVLVPYYKNNLPLTIKYIIDRIKDSNFKLSSKLKSSRAKQSSKSVTEKKSKTIERPKLVRSADLNLDDKILDPKLMLRRSSSNLSSKNLQRRQVDFSKPVLKSKSMTELNPPTSVFTTQARKLKKPKPNTSLNLSKSFSQVSATPMKPPPKKLIQDLRTPVGVSQPSFINSSPIKEVLLSPINERFKNIDTLKTPVAVNSSPVMVLSSERKKRPGEPIDFIDSPFLDSLRGSSINGSSLPYNNNEDRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYD7</accession>
    <name>G3AYD7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_101538</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYD7"/>
    <dbReference type="STRING" id="590646.G3AYD7"/>
    <dbReference type="eggNOG" id="KOG3496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149618_3_1_1"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6349" checksum="DFA1918FEDE60F0C" modified="2011-11-16" version="1">MAEETKSTEKPKPCCVCLDEKKIRDACLLQNGQESGKCDSIISQYKVCMKGYGFEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYF5</accession>
    <name>G3AYF5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="8">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_118629</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="8"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYF5"/>
    <dbReference type="STRING" id="590646.G3AYF5"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_1_0_1"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV65839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="184" mass="20151" checksum="F505ABF3609DF26C" modified="2011-11-16" version="1">MSQINEIAKELKGNLKQFPNFPSEGILFEDFLPIFSKPELFQKLVDAFKLHVGDKKVDYIVGLESRGFLFGPTLALALNAGFIPVRKPGKLPGPTFQAEFQKEYGSDKFEIQQGVIPEGAKVIIVDDILATGGSASAAGELVKLSKAEVIEYLFVMELDFLKGRDKLGKPVFTLLSGQAEKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYJ0</accession>
    <name>G3AYJ0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor IIIC 90kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYJ0"/>
    <dbReference type="STRING" id="590646.G3AYJ0"/>
    <dbReference type="eggNOG" id="ENOG502RQMY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_369188_0_0_1"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="696" mass="79270" checksum="1E3E21AD31E5A8A3" modified="2011-11-16" version="1">MILTQNISRSLVAHSACDIVQWSGNSQLAINGENQLVILDPKLPNLHKSIISQVEYNHTIENFSTDKNVLNTEDMFSQSSILHTEKLIQLDVGKFNKVTFNSSSSTFEFNRITEPCFVKHQWSQLSPSDKNCYLGVLLNTGEFLVLKRTSKFSDQYIVVHNFFDVLLEVNGIEDADEITIDHSQYRSLKVKDFNFVQVSNSLHISVLTESGEIIFFKDGQVEFSIPASASAIAYEAIQYDGITYIAWKTIDNEVYVYDSTSGSRLILMASRFKIGKLLWDSSRLFVTRYRKVAVYHTSGDFFDVDIGEGNIASIVPLGDKVIIAYDHGKFDIVDLATKTVSPCTVLEKYVSNHLLKYSLNGDDNKNLSTDGNFITVGVSLNKNGILSIIHKIYPKNSINYKILSKSSFTIGFVSVSEILEIEQNNTLQTSLSSINQFWFHKFKQILVFPKNFQISSSTAFIFEHLTNLETLKQTLPKINTISLKPNKVNDFKEYLFRNFTANSQVIGYQALYNFNIVLINANNSLASKVGRLDIANSAKHPSEKLEELNKRLLEEQELIEFTIFQFLIKVIVSFDYPIKNDIDKFVFMNYYLLLNKSFELPFNDTDITVTLQNKFVTESFTVSKTATFSKLIQSNSEHYWPRCELTLLPLIDEVNLTDELERFNYLLRKPSPDGLACDLLNTLSYCIITGNKIHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYT8</accession>
    <name>G3AYT8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_118848</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYT8"/>
    <dbReference type="STRING" id="590646.G3AYT8"/>
    <dbReference type="GeneID" id="18248661"/>
    <dbReference type="KEGG" id="cten:18248661"/>
    <dbReference type="eggNOG" id="KOG2220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003661_0_0_1"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="4"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="777"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="793"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="837"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="882"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="952" mass="108459" checksum="5641B754C6D3B8AD" modified="2011-11-16" version="1">MKTYILSVPTKKYDEVNWVQPLDKYLQAIYGDSHEYQSDLTGFDKLRQDLKGVNADTTGLKLYFKYYSQLELLDLRIAFNQISSKKLNFTWHDAFQKSVNHKQHSLPFEKANILFNIASVLSKIGCKKYEEAHISGDLGSSDTFKEALQYFQQAAGVFEFISENFLHAPSDDLSQSTLLFLRRLMLAQSQEIFVLKVITSDLDQTKNSLIAKLCASASEHFLECHKMIDSSIGARESQSTSDFEIVGDDEDGDLERIVDPVYDPDSEKSSNKITVKLDILWTSLISFKSVYYKSLSYYFNGLQLESGNRFGNAIAYFTKSQDSLNQLSTITLKQLSNAGVNGVFEVLDNYKYQKDALSIKLAELNKENDLIYHEIIPSLVTLPEIKALDSTKVIPINQIAQLNEISDNNYVNFLKNVVPIDTHELLSYYSEEKSQFLRNEIDMVDVSNEELSSVLEYLKMPKAIVNLKQIIGDDQTESQTKGPTAIEPGIIEKANEIHRHHSADIANKAKIVETRKKIYALITEIESQTNNFSGSKYKDDTVNIKKSLYDATTPDDKLFALISVENSHLYNILGKGVNSQEFKGLFEVKGQEPSTFDKEISLLDIVDVPSKSTNEVQQQIKKIEDILYDLNVIKSNKLKLVETLKKEIHNDDISDIIVLNSKSKSINEIKSVIFPEELKKFDPYAQELDKLIENQKTFINNLKEEWASLSTNEKVKEIQSSKTFKETLMKDQMQRVNEFYNNWKTYSLGLNRGVEFYSKLLSFVQSMKRRITTEQEESLSDRFGGMNLQNTGQAQAPQQYNQSQIRPQASQYAQQPQYSGQHKNYQPPAPGRYSLPSGPNSLAASPHSQLSDGQYFPQPLLKRTSTSSSYDRPPPSLPPKQPQYSQPPQQQYTQPSQQQYSQPPQQYSNPNQGYPYQPQAPPQPPQQGSSSSLIYDQPSTYNPNMYNFFSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZB0</accession>
    <name>G3AZB0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112911</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZB0"/>
    <dbReference type="STRING" id="590646.G3AZB0"/>
    <dbReference type="GeneID" id="18246732"/>
    <dbReference type="KEGG" id="cten:18246732"/>
    <dbReference type="eggNOG" id="KOG1779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130128_3_0_1"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="82" mass="8841" checksum="47EC892A74042858" modified="2011-11-16" version="1">MVLVQDLLNPSPASEAQKHKKKALVQAPRSYFMDVKCHGCMNITTVFSHAQTAVTCDGCATVLCTPTGGKAKLTEGSSFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZB1</accession>
    <name>G3AZB1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial ribosome small subunit component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_97113</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZB1"/>
    <dbReference type="STRING" id="590646.G3AZB1"/>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024759_0_0_1"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016522">
        <property type="entry name" value="RSM22_mit_bud"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007797">
        <property type="entry name" value="RSM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="683" mass="78037" checksum="3D24F37DFFC53E26" modified="2011-11-16" version="1">MWSRHMSSPFRNDDGSFIKGANAEEARLHDNTLKGRAHHTAIRLPDVIADTINNNILRLTSPGRLRTKVADIYQSVQKEQLQSAPTNGIEANAHIAALFLQDYAHCYQVLQELKKRMGPSFSPKRILTVGYGPATGMVALNEVMGDTFNPEYKDAYVIGRENREMKKRAKIILSRQLNEQPFGEIALEEAEEVAETETEDALTEEQAPETPEYVGPVDTTRIEIRTKLRDSLPTAKKYDLIIVNHSLLTKEHHFPRDVDVNMHMLLRLLEPQGHIVLVERGNSVGFETVARARQIMIRPESFEKERGKVPRPYIKGSSIKPQKLRHVDQIITEEHIKHEEKLLEELDKELGQYHASDSDISELEQTIIEKYGDVSEDDLKFEFEDDKRFEVNELGDPTLGPESVDYHLEIVAPCSHHSKCPLQLGDPKYYKIPSHKHRLKFCSFDKVVERPKYTMELKRGKKLATAWDKGAEDGFGFDTMKKSQVKKLSGSGRPGGNNTESGSFTYLIARRASNEISDIQKIEYERVHNASSEVDLSNPTNWPRVLDVPARVKNNVKLTTCAPSGNIEIWQIPKSLGKQEYHDARKVDQGDLWGLGKKSVLVKNQLSEKVRDKLDILSKTQKKTFKKEQRKKVWKKLVSQSEHDFENDIVKFSDVMATNLEQTKKYRKQGQKFDVDVSEYDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZI0</accession>
    <name>G3AZI0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112460</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZI0"/>
    <dbReference type="STRING" id="590646.G3AZI0"/>
    <dbReference type="eggNOG" id="KOG3272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076656_0_0_1"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="221" mass="25843" checksum="0DB832F1261A76FA" modified="2011-11-16" version="1">MVYYFKAQVDTDFETEQYNVYMGRDKVENDPLIRYSNPKNLWFHVDKVSSAHVYLSLTNQQRLQNFKSLSLPSQLLDQLGQLTKNNSIKGNKMASVTIIYTSVDNLVSDGSMDIGTVTFKNQQLVKRFNVGKKDNLVLNKLSKTKTEMSTDEFIANEKSALVQYEREKKDHQRQLQNQQRELAKQHHEQKQRNQDPYADLFTEENMHSNLAVSENYEDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZK3</accession>
    <name>G3AZK3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112478</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZK3"/>
    <dbReference type="eggNOG" id="ENOG502T5XI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1235422_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="220" mass="23401" checksum="F94F49ABCC8852CD" modified="2011-11-16" version="1">MSLSTFRPINSLPLAFYYVSSVLSANSGSLDLDSSDSDSSDDSSSNNDDSNDDSNDDSNGKTATKNTNTAATTNTDTATVKTDTATVKTDTATDTTGTTVWWTPTTMTTDTATTKDTTDKTTDKTTDKTTDKTTDKTTDTDTTGVTYNQYGFTGSQSRWESSTDSSDSSESSSHSTHSTKNKTSLATRNSILFAPERDYTGKKVIFIAGLLGISALFTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZN6</accession>
    <name>G3AZN6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic-AMP phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112502</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclic nucleotide phosphodiesterase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZN6"/>
    <dbReference type="STRING" id="590646.G3AZN6"/>
    <dbReference type="eggNOG" id="ENOG502RFKK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016658_2_1_1"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000962">
        <property type="entry name" value="Cyc_nuc_PDEase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0114">cAMP</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="374" mass="41725" checksum="2B4E590CA12CD667" modified="2011-11-16" version="1">MAFELTFLGSSGGPIEGSNCCILIKPSHISYQDIVERNLQNEVLCVDAGAGLAKLSEVIFNETHDLPSCNLLNLYNDSLSVDEYFKTSTSKPFAVFKGKSPFSAAVDVFKNIKSYLISHPHLDHIYALVLNSPNFTEANPKEVYGSCDTVHALNSHIFNGIIWPNMQEFEIVNLNTVGFESPFDVSSYSVKMFKLSHGKLQRGHRNSSISINENFKGIYQESKSVTYVSSAFLISYKTINSRVLVFGDFESDHISNQNFNEVIWKEIVPMVLDKSLSAIVLECSNCNCVETSLYGHLNPIHLMRELYKLNGFCVNASGTENPLKDMHVIINHVKETDGTFDPRATILRNLEKLNLDYNLGINFSIALSGVSIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZN8</accession>
    <name>G3AZN8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112505</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684206.1">
        <property type="nucleotide sequence ID" value="XM_006684143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZN8"/>
    <dbReference type="GeneID" id="18246550"/>
    <dbReference type="KEGG" id="cten:18246550"/>
    <dbReference type="eggNOG" id="KOG4366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040660_3_0_1"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="28330" checksum="12AF0C65CCED0ABB" modified="2011-11-16" version="1">MNNFWKIVLAVLTLTSYKTIPFAYLFKFYYAYTRYVTSKRWKYLKIGGKNTFDITIEKKGPLAVFEPNVYSSYVSPLEYDMFLHKSNSTYFADMDFARMKLLCQNMQKGFFTYMFNEYNDFKKASVFNYPFVPVARVECTFKKELKLFEKFDVVSRVGAWDDKWLYVISKFVKTSDNRTVAIGVTRYVFKLGRITIPPKEFIKRSELLTSEAEAANEKYLEKFKHFASTDDFEQLCDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B050</accession>
    <name>G3B050_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_133619</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B050"/>
    <dbReference type="STRING" id="590646.G3B050"/>
    <dbReference type="GeneID" id="18249729"/>
    <dbReference type="KEGG" id="cten:18249729"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1264223_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="219" mass="24764" checksum="B0F1EC2C7D83C37A" modified="2011-11-16" version="1" fragment="single">LPGQDFSKVLTNYFKHGNIASFVRQLHMYGFHKVNDNNTDNSVWEFKHSSGKFRKDDEDSLVYIKRRSSSNTKNGQPPAASHAPDHGMVYQQPAVYPYYYNEYMVPVQYVPYNVNYPAVYSPQYQMVQPPVYYGAPQGSHQAPVHQVPPRAYSDPQPAVGVQMLVPGAAPTRPEMAEPMPRTAHTSPKAIYHRPSNTSPHTVSTTPHSQQLHSQHSHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0B4</accession>
    <name>G3B0B4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Sulfiredoxin</fullName>
            <ecNumber evidence="4 14">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_92582</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the sulfiredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="4 14"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685046.1">
        <property type="nucleotide sequence ID" value="XM_006684983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0B4"/>
    <dbReference type="STRING" id="590646.G3B0B4"/>
    <dbReference type="GeneID" id="18250208"/>
    <dbReference type="KEGG" id="cten:18250208"/>
    <dbReference type="eggNOG" id="KOG3388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124532_1_1_1"/>
    <dbReference type="OrthoDB" id="10023328at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1530.10:FF:000005">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017267">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="17">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="16">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV65360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="132" mass="14803" checksum="D6B37823780B0654" modified="2011-11-16" version="1">MSIQTANIKVSEVPLSQIRRPIPPVLDYQKIDAMVSTLNGVPMASATCPIEEISSGELPPIDVFRVREEGKDYYFAFGGCHRFQAYDRINTDGTKEVMVKCKLLPATRKTLKLYLGGSVDEMFADLDKERET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0C0</accession>
    <name>G3B0C0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_113086</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685051.1">
        <property type="nucleotide sequence ID" value="XM_006684988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0C0"/>
    <dbReference type="STRING" id="590646.G3B0C0"/>
    <dbReference type="GeneID" id="18246818"/>
    <dbReference type="KEGG" id="cten:18246818"/>
    <dbReference type="HOGENOM" id="CLU_776115_0_0_1"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin N-terminal coiled-coil" evidence="12">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Shugoshin C-terminal" evidence="11">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="41090" checksum="9B69B28B76725CFE" modified="2011-11-16" version="1">MARPSSSSLSFVHLAQEKTREKERENSFQATTEKEDINTEKYVLQNKTLTRNNEIMTTKLLQMEKRVADLINENVSLRANKTELDVKLQLEAKLDLLESALTEKINDIYHCIQTFREREGLSTHKRPRLGEVAEEPAKSTVRLRRYSLGPGPRRRSIGRPIKIFEDVTPEVEKEAEDRVEITEALPQEDKENRTPPATSESDMSSPSPTVNRKRVPQKLNFESAKRHTMSSLEEPTVKAASQEPVSRITKSGRSRMSMPFLSQEVPKRSSRHRKPVDYKEPSLGKKMRRESAHFVDAVTDDYYTCVKKEKHRTPMSRVDSNKPNLPHKVQSKKNDDISVDDFTDGAKRTSRRYTINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0C2</accession>
    <name>G3B0C2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_102698</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685052.1">
        <property type="nucleotide sequence ID" value="XM_006684989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0C2"/>
    <dbReference type="STRING" id="590646.G3B0C2"/>
    <dbReference type="GeneID" id="18245573"/>
    <dbReference type="KEGG" id="cten:18245573"/>
    <dbReference type="eggNOG" id="KOG4781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052827_2_2_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF4">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="117"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="216" mass="24051" checksum="176ADBEA14EC33F9" modified="2011-11-16" version="1">MFRTFTRITTPVVAGVVAFGVFPFRKSQFDTHESKSNQQILDTIKQLPLYNSLVQDPTFTLQDPRKQFPKQHHQNMVTAGILYGKDLFEVDPVVFSNGKGDLFAFNYLGEKLTSEDGQIHNGVTSTMLDEGLCMAGFPLLPSKKGVTAKLSINFQNQAPPNSIVLLKAHVTEQKGRKAVVEGSIVTVDQKPVTIATATCIVVEPKWFKYLSWLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0P6</accession>
    <name>G3B0P6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_102780</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0P6"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032917_1_1_1"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016477520" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="17"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="352" mass="41237" checksum="AFF44D421AAE1052" modified="2011-11-16" version="1">MNLLIWLTLFLYTVEASPGDKLKRFKRCFRQCKLVNCVVGTYDSEWEFTPFNEHLKVLYWTCDQDCDYQCQRIITAERRHKNKNVLQFHGKWPFHRVYGIQELVSMVFSIGNLIPHAIGLKKLLQQLKTSTSHQATTQTAVLIASCVITCCAWVFSSIFHVRDFLLTERLDYFFAGLTVLSGLYAITSRYFRLFEPENLIKLVSSTVLFISVYSMHVYRLVTDWSYTYNMQANVIVGIVQNLFMVAVCFGLYSQYYHDKSTSTNNTMYAKRVLWSSFFTRSDKIFSLYPIFLGTIVILGMSLEIFDFSPVFHDLVDAHSLWHLVTIIPASYGWYEWLIWDIRENITPKQKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0T2</accession>
    <name>G3B0T2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_129990</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685601.1">
        <property type="nucleotide sequence ID" value="XM_006685538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0T2"/>
    <dbReference type="GeneID" id="18249414"/>
    <dbReference type="KEGG" id="cten:18249414"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="56814" checksum="DAAA4EFAFE70667A" modified="2011-11-16" version="1">MSSEKINHEVSVEEQGSTSIIEDHEALTSMKGLDKAFEFLDGKTISYTAEEEKAVLKRIDWHVMPLLFLLYLIQFADKTSLSYASLMGIRIDTHTDVGQRYSWVSSIFYAGYIFFEFPTTYFLTKLPIGKFLTFNILAWGIVITCSCAASNYASLLVLRFLLGMFECSITPGVVLIISIWYKRSEQGKRLGILLAANGCATILISPVAFGLSYITGAAIASWKILFLIFGSVTIVLGTFFFFYFPDNQLSAKFLSEEEKVIAIDRIRTNFQGVGSKSWKWYQFREAFQDPRTYLYMLYSLLMNIPNGGVTTFGSIIINSFGFDSQHSLLLSMPGGAVDIIFKLCIPALSDKLMDKSLPAAIAIAFPMIGGIMMSTLDVDRKGPLLVGYYFISAAGASWGLVMSMIGASSLGSTKKSVVNTCQIVCYAAGNWVGPQLWLTREAPVYPTGKKLVGIFYGCALGTLLVIRFVNIRENRRRDKLQAEGKIPPPPENAEFLDLTDFEQLNMRYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0U6</accession>
    <name>G3B0U6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_103370</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685611.1">
        <property type="nucleotide sequence ID" value="XM_006685548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0U6"/>
    <dbReference type="GeneID" id="18245620"/>
    <dbReference type="KEGG" id="cten:18245620"/>
    <dbReference type="eggNOG" id="KOG4148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169286_3_1_1"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="102" mass="12290" checksum="FD3C39C899FBD7DA" modified="2011-11-16" version="1">MHPQLDKVRFDPCIALMDALEECHRQEFMKKALGMCNFEKDELDKCLHHTRVNNANDRIRQSKLRQKEVEQRRKAREEELYGKNNYLKKVIEKQMEQEGSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0X8</accession>
    <name>G3B0X8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannan polymerase I complex VAN1 subunit (M-pol I subunit VAN1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_97655</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0X8"/>
    <dbReference type="STRING" id="590646.G3B0X8"/>
    <dbReference type="eggNOG" id="ENOG502QRNF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017872_1_1_1"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000163">
        <property type="entry name" value="Van1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF5">
        <property type="entry name" value="MANNAN POLYMERASE I COMPLEX VAN1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="459" mass="52878" checksum="AEC4B752EF26C59A" modified="2011-11-16" version="1">MGQQFNSELPVHHRFSPKKNVLIITTKRLLVGITALVVLFLLVGNGSKVIPELQAQEIDTQIIDNNLEKVYEVTKDGVAERSAGPDFEYYDLNSFTGSAQGMKNQDVVLFLMPLRNAEHVLSMAFHNIMNLTYDHSLIDIAFLVSDCSEGDTTLEKTFEYSVALQNGTLVDKLQREEAIKAKYRRGSSDLYQLYMDQDYMNNVRKSYNPRYYHKDYSKPFRSITIYRKDFGQAIGQGFSDRHAVKVQGIRRKLMGRARNWLTTNALKPYHSWVYWRDVDIETCPGSVIQDLMKHDYDVMVPNVWRPLPSFLVDEPPFEQPYDLNSWIESDPALELASKLDEDDVIVEGYAEYPTWRVHLAYIRDRNGDPNEAVDLDGVGGVSILAKAKLFRQGVHFPAFTFLNHAETEAFGKMSKKMGFRVGGLPHYTIWHIYEPSEDDLMKIAKLERKKRRQKQTKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B114</accession>
    <name>G3B114_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_104031</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B114"/>
    <dbReference type="STRING" id="590646.G3B114"/>
    <dbReference type="GeneID" id="18245674"/>
    <dbReference type="KEGG" id="cten:18245674"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_0_1"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="303" mass="32869" checksum="4001A407D2B33DB0" modified="2011-11-16" version="1">MSSIVKAPLAKSLKIALIQISAGSDKAANLTKVKKFIANAVKESKIGKLDLIMLPECFNSPYAVDQFANYAEVIPSGETTSFLSGLAKEHKVFLIGGSIPELDEAESKVYNTSLTFSPTGELIAKHRKAHLFDIDIPGGITFKESVSLTGGDKATVLKLGDFGNIGIGICYDIRFPELATIATRSPYNSFGMFYPGAFNTTTGPMHWHLLARSRSVDNQIFTVLCSPARDVEGGGYQAYGHSLVVDPAGNIISEAGEGEEIIYAELDPSLLPKVREAIPVHFQRRFDIYPDYVSDESIKVGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1A8</accession>
    <name>G3B1A8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_134231</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1A8"/>
    <dbReference type="STRING" id="590646.G3B1A8"/>
    <dbReference type="GeneID" id="18249781"/>
    <dbReference type="KEGG" id="cten:18249781"/>
    <dbReference type="eggNOG" id="KOG1148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2420:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="14">
        <location>
            <begin position="164"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="244"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="561"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="668"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV64926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="788" mass="90099" checksum="A4D8050C950057C2" modified="2011-11-16" version="1">METELITKFKEFGLDDKRAADVTKNKKVSKSFEDITAVSPESHVDDEKKLINLHALAAELKGSDIPKINLVVIAILDGRLKSSLQISEAAKYVKEKGESATNEELEVASGVGIELSDDEVKSIITKSLDAIEAEIVEKRYSILPKMLGDMKKVSELKWAKPSLFKPIIDEYFLTKIGPKDDRDVVKKEKKKKAPTAGASSNKGVVEKERSMFTEGFLGDLHKPGENPQKYPELMKKHLEFTKGQVLTRFPPEPNGYLHIGHSKAIMVNFGYAAYHSGKCYLRFDDTNPEAEEEIYFTKIEETIKWLGYTPWKITYSSDYFDELYDLAEELIKAERAYVDHSTPEEIKAQRGLKDDGTLGGERFASKYRSRTVDENLKEFRKMRDGEYGVGEAFLRMKQDLESPNPQMWDLVAYRVLDKPHHRTGSKWKIYPTYDFTHCLVDSFENISHSLCTTEFRLSRVSYEWLCDELKVYRPAQREYGRLNLTGTVLSKRKIAKLVNDHYVRGWDDPRLYTLEAIRRRGIPPGAILSFINTLGVTTSTTNIQIVRFESAVRSYLDATTPRLMMLLHPILVELDNVGDDFREEVEIPFQKGLSSRKLTFTKHFYIDADDYRDEASKEYFRLAPGQPVGLMKVPFNVSVNKVVKDDNGNITKIHCNYDNEKKSKPKTFIQWLPKDEVIKVDQIRIYNQLFHSENPSAHPDGFLKDINPDSEIIIKDALVEKSFELVKEKSPLNVPNPSSEFNIKEAAGNETVRFQALRVGYFGVDKDSTDDKLVLNRIVTLKEDSAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1D8</accession>
    <name>G3B1D8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113692</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1D8"/>
    <dbReference type="eggNOG" id="ENOG502RJW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061755_0_0_1"/>
    <dbReference type="OrthoDB" id="4078735at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="264" mass="30291" checksum="532E0F7C53F09FBF" modified="2011-11-16" version="1">MAFNKYQLNYPTTRIVVNHEEDEVRSILSDDQSSWVLFNPDSDILSSTTQDHDQDDESTDAEISQDEDIGDHREPQSSRQADQSSRQPTQPDVESDNDTDTDSLIDNLDPSQSRLEGLFKKSYDRINNWNLTSDVVDDNVASWDLDEDLSNNSLDTSILDKRPFYGNELIRNLNKKDLQKFRKIHANLRNYLNRKPPSPLLEQLLSKMSTQTISRPQPPYNLNMGYNRYLKATISSYYDYDDLTSETASSSMVLCGGGETWNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1M2</accession>
    <name>G3B1M2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clc chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_104029</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1M2"/>
    <dbReference type="GeneID" id="18245673"/>
    <dbReference type="KEGG" id="cten:18245673"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="828" mass="91629" checksum="542369BCCB5B7D3E" modified="2011-11-16" version="1">MSYYRSQNGTQVVLDDDAIPILRYTPPFDSQSQESEIYKSSAPVPKTYMNNTFIDWYSETTLISHSSVSFTYKKWLVIVITAVVSGYAVTIIDLISVWLNDLRKGICLSDLDKWSLLNPYSSCPAGAWNNWSEILVNSDRVVASTLVNFPIFVITGSVCAALAIYVSQTEPSIQQSGIPEVKSIIQGFNYNLDKYLGLRTLFLEIVGLSLVSASGFWLGKEGPFVHVACCILNVMYNLILGKLQGTEAVRRELLSAATATGISLAFNSPIGGVLFVLECIPSYFFPTKIMWNSFVSAAIGLVVLVGFRSFTEGINFNEEDLFSVEFGGFSWLILELIPFIGLGVIGGFYGWVFISIYTWTMKSRASIQQRLCTIFRVPIEKANYLEILLIFFVTCILNFPIAMSRLQLDAFLKSLFINCPEPGESNEQNSASLMCSSSNVVTSIKLLYIAVQALFLSAYSFGTILPGGVLMPSLVIGAVSGRFVGIMSKGIQSLLFGSSDTCTQNSCLVSPASYAVIGAGAFMTGVTKLTMCVVVILFELSGALSYVLPIMVAVMVSKFVSDYLCSENIYDALLTHGFNKSKIVTGDVMYNVGKGSGLFQFSNSTAFIKAKLPEVTVSKVMIPVKNTKCIYLVSDEAMTLNQLHAFLIENTHEGFPLLASPTNPISLGYIHKQDIYTSLSHIDSANGEDIISFQVSGVPTEVLSHQIRHEQGVDPNTLIKLELEPEKPFIIMNDKTWLSLVIDVFEKMYLNYLIIVDSGNHTPRLMTGFIDRFIIAKLVEEQFASIRDEPMLDEEYMQQFDIEAEDSIEGANQSLLFHRERESIELIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1S2</accession>
    <name>G3B1S2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_103890</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1S2"/>
    <dbReference type="STRING" id="590646.G3B1S2"/>
    <dbReference type="eggNOG" id="ENOG502QPMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039097_0_0_1"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="389" mass="44876" checksum="E8093573E95F12F3" modified="2011-11-16" version="1">MSDSKEKPVEKVTPPKKGWSNPALQMMGIPCLSLPSRNWMIFWTVLASIGGGYAYDRYEQKQIRKQYMAKVEELGREPYDSHRLPRKLTVFIAPPPDDFLEVSMGYFRRYVKPVLNSASIDFDILVANKQGDIRSSVSERIRQLRRDAIQNNQTPPQNSNGTSWTKLLTFKNVKELYDTKDVLGFYYRYPTITPVRDDVNAASHAGGVVCMGRGAYKEYIQGVHEGLLGPLEAPQIEEQVSVENSDEEQDKNEAKAPAPFIKPEQYPQAQLAPELDLSSIIRDDKGVPVLFEQPIYVFPVMNVLGFKNTLRKIYNFFTKRHAAEDFSERTLHIVDNKVVPFEYKHQYLAKEEEPLWPKHWVEKGKERNSEWVQEMITDDRVTSRLKVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B297</accession>
    <name>G3B297_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_92867</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685431.1">
        <property type="nucleotide sequence ID" value="XM_006685368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B297"/>
    <dbReference type="STRING" id="590646.G3B297"/>
    <dbReference type="GeneID" id="18250237"/>
    <dbReference type="KEGG" id="cten:18250237"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_834186_0_0_1"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="39229" checksum="70EAA479D998CB14" modified="2011-11-16" version="1">MDFSGIKFSDFKSRIESIKYPYSIDWNGLKIIPQSFRRKAKIGVFTIDEQFDELHRTLGIVEASIKNLIKYSDMYTANVTLQLKSAKEIGDLFSSLCDPYISFDQQTRNEVKDMSLDKIVNRLFTSEDQTKEFMSQCFHFKVTESFIVKVQELIEVVGDPTEVSKTITSKCQVCLFLLENIKRFVRKRNHALDNYDYVVSQIELLLKKSKEKFQELSVKESQKLFNLQRRLEVLRSEYDTINTLLLKELPSFFHMVDSLLSPIKYLLYYNQLIFNYQTISKMLEFQEKSRIALQWDLDSIDITEFQQRIESLSLLQTTRSVSNMEIFEDSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2I4</accession>
    <name>G3B2I4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113474</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2I4"/>
    <dbReference type="HOGENOM" id="CLU_1414983_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="192" mass="20115" checksum="88056EFF3F813951" modified="2011-11-16" version="1">MAQASASNSSLVHGPHGSTLTLNQSDAVTPHSPYNQSPLLLSNTNSRNNSISTTFDINFINSNNNSSSNSRRSSIAPDFFPNPLKDINPSHKRNVSNNSGKAANQNVPPPLSLNQPSHPQFAVPQLIGNSPTQSAFTLSKSQSNLSNVLSASNLHHQLGANVSSGSHPKKNTNNGSNNGAGNGKISVSSLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2J1</accession>
    <name>G3B2J1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Las1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_104157</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2J1"/>
    <dbReference type="STRING" id="590646.G3B2J1"/>
    <dbReference type="GeneID" id="18245692"/>
    <dbReference type="KEGG" id="cten:18245692"/>
    <dbReference type="eggNOG" id="KOG2425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043823_0_0_1"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="467" mass="53797" checksum="4913EFAF255389C7" modified="2011-11-16" version="1">MVTADQIGRMLNRQPSVVSYKSAEDLIKLKDWFYNFDEHRDHRHRAVQIVKAISSRGRIPHAIESTSLLTSLCLSDPEMSSKSSPQVVIQKDSYLLQLSYSMALTRFVNGLLDPLQQSNFAIPLHQLAKSLQMPSYFVELRHTATHEKLPSLALLRTTAKNALNWLYDNYWNKIEDIESDIEDEVEELLSERDQILIQDAVKASDSSIKELVANLKVYKKIRKQDLNFIYKFGNSSDTGKKYWKAVSKIKSILASNPQITFRVLIFKDFLIYNKMDPVKAKKINSFLAILFKLYNPLLEELGPYFKRQLYEVILRSLKSEFTMVETQINKKLGFEITHEYETTQLCGWVVYLYSSMDDQGKKRIGSLLQDISSLNDESKMEILQGLNKIELLEDEKQQVEVVHESVGKRLKLKKYEQVESLDSILGTQAPALKKQKIQPSDDVSTSKKTYFFEPHAKWTATPFGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2L2</accession>
    <name>G3B2L2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SPS-sensor component PTR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_120576</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2L2"/>
    <dbReference type="STRING" id="590646.G3B2L2"/>
    <dbReference type="GeneID" id="18248790"/>
    <dbReference type="KEGG" id="cten:18248790"/>
    <dbReference type="eggNOG" id="ENOG502QUFR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028479_0_0_1"/>
    <dbReference type="OrthoDB" id="5324744at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="80371" checksum="4643B8F58DE394A0" modified="2011-11-16" version="1">MERIKVSSLEPLLKLSASVDPTDLCSDAAVLSCGCVVSERFFLPLVDSSGTTSCPECMKSNVTFLKPIRQLRDLYNIISQVLSESTPRTRRRSSSKKSIKGPNDPINERSVGEQMDLVSLFYRYAKEETSQYLVSSDNAHVNPIDINHQRPKSNSSYINSNSISPLRKMSINPGESVGMLSESYLERERVKSKAPKYEDLLVSDITEEKEYNFSKCFPFHRKLTTFQTQQGRLFSSSLFKGSMIKKTGRFIANDIHTSTDFVTGQEITRFVSITEKRWELYELVEDPEMHPVLVCCGKSSGEYGPSFNELREDYGHEVVIRNDFSGNSSANSTSTDLGHKKRLGSWEFISCRLSGDFLAISGTKGIMRVFNVSKTSLPHELGQPVYTYITNFPIRCIAISNNDPLIACGITAKERISGKEQPFVVLHKLVRSVAADRIIGSVEPITITIPYRDPIKLINFNATSTHLMCCTVWESRYLIIRLRSSGSDNFRKPRLIWTDSSVLRSSKRKKSDGALYDDSDDDNSDDNALMMDNEGITDAQFGAIPNTVVLTSCSLQHRPPLMLRLEGSTIDSSQGRHLSDALSFESSLNSRHDGNDDGYDITNIKSSELLMKFSEVGFSIHKSALSPRRDALAFLDKDGRVYLVSIPNFELNLNSSPKKVVVLLGEVANAERYVEAAAISFSADGGRVYVSDRRGALSVFDFTKGIPGQDSDVVKCRIISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2U1</accession>
    <name>G3B2U1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_103499</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2U1"/>
    <dbReference type="STRING" id="590646.G3B2U1"/>
    <dbReference type="GeneID" id="18245633"/>
    <dbReference type="KEGG" id="cten:18245633"/>
    <dbReference type="eggNOG" id="ENOG502QPVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015609_0_0_1"/>
    <dbReference type="OrthoDB" id="2341546at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="638"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="648"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="867" mass="97679" checksum="0026D035CA31C831" modified="2011-11-16" version="1">MSQELQTLNEQLSHEESQPDALFAESNHSANNKSGKPRRMACVECRQQKSRCDAHERHPSPCTRCSKKGLKCDLKSGYKRTYKRARIAQIEREFSELKKTLTTAQASELFSKIPTLSQVQELRDTDGDFSESYSSPQPQSHGAHPQGITHTTGDTNSSSIPNTPSINRNIEMYAKEPSEPSELVVVPEYILFCGEKTLDTITLQPDTIKSLYLEYVHHYHPILPVVDVMKGPEKIYKLCPALFWVIMFVSLRRIYNDPSRELLVRLSPVIKDILAEITISPITRYNPTEEDEPILNACSVYSVQAFLIYTYWPPITSSLSADTSWNTIGLALFHAIRIGLNAPVVNSSNPKTPQQLSMAHEQTKTWILCNIVSQTIATAFGFPAFVQFDSSIWSPLRTSSPIKIPKSIRFMLEIASFEDQATKTLNSNPIDPYGLIDPTERLPLLKVLLRQLDELEFKLVDELPSSESYRKFQLLSARVHLLTYYFMDSSRIALFELQKGLVRLYNAAIALINFAHLCSTRDKNFIKYLPGVYVLSIWQASCIIAKLAHSPLKQYIDLGSGKQSYQAAITLAAKASILKHDMAHRSSGIMRNMWQVLRTLDEKKLSTLTIDVRSRMAASAFFDCLYVLRDQVGMLKLNNRNDSTEPTNGEDNDDGGSNEDDEEYGYQEEALESDEERREVSQKSTPSSSNSSKARKLRSLSNTVNAESKARKIIRTIPLDPQPISANNKRSNIFKVIDNSNDSSPQVRSEPSDDRNMVARGKAEDFRSLTNSPPPLFTNNHRMAITGNTIRSQNRGFQSSQVGDYAAPVARTPVESRRTDELAHMVLNESPLQGGLENLEMDVLDINSDLLWKDVDSVMNDFGFHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2V3</accession>
    <name>G3B2V3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_134081</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686018.1">
        <property type="nucleotide sequence ID" value="XM_006685955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2V3"/>
    <dbReference type="STRING" id="590646.G3B2V3"/>
    <dbReference type="GeneID" id="18249765"/>
    <dbReference type="KEGG" id="cten:18249765"/>
    <dbReference type="eggNOG" id="KOG3482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_12_0_1"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="104" mass="11693" checksum="41F47C0CBB8A8B56" modified="2011-11-16" version="1">MSSTSFNPINPKPFLKTLLNKRVIVRLKWNKTEYTGNLVSVDNYMNFQLDDASETAYVDGKKTAETVGEVFIRCNNVLFVREATDTATAAVPENEAVEAIEMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3H8</accession>
    <name>G3B3H8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114214</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686712.1">
        <property type="nucleotide sequence ID" value="XM_006686649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3H8"/>
    <dbReference type="GeneID" id="18247316"/>
    <dbReference type="KEGG" id="cten:18247316"/>
    <dbReference type="eggNOG" id="ENOG502S3TQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012348_0_0_1"/>
    <dbReference type="OrthoDB" id="3981113at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="237" mass="25488" checksum="C43CE3704D157DDF" modified="2011-11-16" version="1">MAHPDASIKSIYSGKVNFSSSYDADPPEFDSDSQLDDSLSRLSNESLSSRNLKIFNVNSDISQNDLFNDSSSDGESNGDGNLSVPSPSLSRNSTTSCLSTTATKDGIEGRKFHRKGPKAYSNHIISSMIKTTTVKSVRVSSADRVPSEKTLNGNTDVKGSKVTSIHIDTSPQQSPAGGRGSPTPMAQGAYSYSEVSFKTTDAEFEGFGGHEQPALPPFYKQPDMSLWSKIDMLNPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3M7</accession>
    <name>G3B3M7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_114257</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3M7"/>
    <dbReference type="STRING" id="590646.G3B3M7"/>
    <dbReference type="GeneID" id="18247340"/>
    <dbReference type="KEGG" id="cten:18247340"/>
    <dbReference type="eggNOG" id="KOG1462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016743_3_0_1"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="11">
        <location>
            <begin position="327"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="470" mass="52849" checksum="DD502275A1215C31" modified="2011-11-16" version="1">MEFHAFILCGPGKGLSPFSQQRSSGQPKALLPVANRPMIEGVLDWCEMAFFPKVTLIVNDDSEHQISLELDEYKRKLAAANKAKQTADESSPYTTDFSILNLETDFSGYVLYHLYKSGIHPYHNFVVLPCDFVTNLPPQVFIEAYRNKSDKDVGLLVHYRNTLDIEDKKTKIFPTNYTFYGESKDDDSTKLLDIYSAEDVEFHKTLKIRTQMTWRYPNTIISKKLLNSGIFFGSGDIFTIFAANPNRYTEAYFLCRPLTKIIRDLARRSWRHSKLQETIAFLIIPDIATFYRINNTPVLMEANRSVLQQQAIQKSQSGVLPAAREKNAANVGIDSLIGDNSVLGERTNVKMTVIGKNCKIGKRVRLTGSLVMDNVVIDDDVSLENCIVGSDVIIHSKSKLTNCNVEAMHEVVNGSHFKGETLLSLSLEGIVENGMETATSEEDSSGSDDESDDYDDDVEYDDNADGLFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3W7</accession>
    <name>G3B3W7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_121360</name>
        <name evidence="12" type="ORF">CANTEDRAFT_132743</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3W7"/>
    <dbReference type="STRING" id="590646.G3B3W7"/>
    <dbReference type="GeneID" id="18248843"/>
    <dbReference type="GeneID" id="18249642"/>
    <dbReference type="KEGG" id="cten:18248843"/>
    <dbReference type="KEGG" id="cten:18249642"/>
    <dbReference type="eggNOG" id="KOG0052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="OrthoDB" id="3969558at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="458" mass="49898" checksum="5DAFE0595453C157" modified="2011-11-16" version="1">MGKGKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYHVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGVGEFEAGISKDGQTREHALLAYTLGVQQLIVAINKMDSVKWDKNRFEEIVKETTNFVKKVGYNPKSVPFVPISGWNGDNMIEPSPNCPWYKGWEKETKAGKSSGKTLLEAIDAIDPPSRPTDKALRLPLQDVYKIGGIGTVPVGRVETGIIKAGMIVTFAPAGVTTEVKSVEMHHELLDEGVPGDNVGFNVKNVSVKEIRRGNVCGDSKNDPPKGCDSFDAQVIVLNHPGQISSGYSPVLDCHTAHIACKFDTLLKKIDRRTGKVLEENPKFIKSGDAAMVKMVPSKPMCVEAFTEYPPLGRFAVRDMRQTVAVGVIKAVEKSDKAGKVTKAAQKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B474</accession>
    <name>G3B474_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_93309</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686107.1">
        <property type="nucleotide sequence ID" value="XM_006686044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B474"/>
    <dbReference type="STRING" id="590646.G3B474"/>
    <dbReference type="GeneID" id="18250272"/>
    <dbReference type="KEGG" id="cten:18250272"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320537_0_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="776"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="497"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="653"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="544"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="851" mass="94937" checksum="EF39E406162C3273" modified="2011-11-16" version="1">MNIDETYEEDVYMSQDFDPESPIFVNDSLERDGGSNGFIMDNKTTEQYFMGDPDPSEPMSDNGFDNLHAESLIQAASESDHTNTHDKAGDLSQTSGDHSNISFSIPGAFKENNYMEIDNSPPFTIDSDLFFDSASNNNNNSNHNTTNNQSGGKEASTRETLFPHNQFFIRQYKNSLSSSNQGHSPNNNVSPNSNVVGSNVNTPVPTQNPHFDTPNSVINPNYLPSENQYYDDASVYSSIVNDNESVDNHSQFNRRSISMTQTNLSVGPYPPVNPYANDLSPLTTTTSLTHSVNSLHSTQPSFFSAHQYLPRHSLEVPLSHRNSVDYISKNRNSIEPSTSVQRQPRANNNRYLSFTNSISNYIPFMGDKNNSNNNNNNQRTSPISGPPSPISNGSGSTPFMNQPAAQRQQSKHLIRSIFKLNPQNAQESMENPEVNDNESPDIEGITEEITASEFDRDLNAEFLVLSPTGEESELYGLNPLPNNISSKKVKKPKRSIFTRFKGPVKQESTDELDFNNDDSSKHSGNNSSNQELDDPQSFDFHGNMSRTPSSANTVRTGNNLQPNLEITNSNGSSHFPDYAALFENVGKRKMIGKNSTFKNKTRVKTEKSGTDTFDEDNDTSFMNTKVKHEKQEFDTFDNDVDSFPNSKVSFEASSTVSSSTTAHSRHPSQYEDSMHDDDDYDRNENGGNSTNVLSNASKRILGSKLMKRKPSKKESELKNIKTKVMADGVEVEVDMKTLNLPQDAQAFPISVVNSKTRTRGRKENKEADLSDSTKIYLCTYCSRRFKRQEHLKRHFRSLHTFEKPYSCDICNKKFSRTDNLNQHLKTHKEEEAAAEAAAAAAAAAATLGEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4D3</accession>
    <name>G3B4D3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_113986</name>
        <name evidence="14" type="ORF">CANTEDRAFT_116768</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4D3"/>
    <dbReference type="STRING" id="590646.G3B4D3"/>
    <dbReference type="GeneID" id="18247205"/>
    <dbReference type="GeneID" id="18248436"/>
    <dbReference type="KEGG" id="cten:18247205"/>
    <dbReference type="KEGG" id="cten:18248436"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="OrthoDB" id="5326060at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000010">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="136" mass="15358" checksum="C973643C480AC67F" modified="2011-11-16" version="1">MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRFQKSTELLIRKLPFQRLVREIAQDFKSDLRFQSSAIGALQESVEAYLVSLFEDTNLCAIHAKRVTIQKKDIQLARRLRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4J0</accession>
    <name>G3B4J0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_130228</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686155.1">
        <property type="nucleotide sequence ID" value="XM_006686092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4J0"/>
    <dbReference type="STRING" id="590646.G3B4J0"/>
    <dbReference type="GeneID" id="18249432"/>
    <dbReference type="KEGG" id="cten:18249432"/>
    <dbReference type="eggNOG" id="KOG2274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008920_1_1_1"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1061" mass="119802" checksum="1CEAE931B2D7C6F3" modified="2011-11-16" version="1">MDQVQLVLKLIEDQNSSNNNSRRVAELEFNHLVAQDPSKVCYVLIQVPMESSYPQYVRQSCLLHLRRLVPKYWSMAFESFSGTPISQDLKSVIRDNLIKLVMTSQPSKIKNSASYVIVQIAVADYPDEWPDLLNTLYEYSRDFNNQPAVEGSLKVLNDLFDDLVTEEQFWDQNVGKQLIDHITSILSTDNLSPEVKINCIDLYKNVLNYLTSGEAFVNDSRKKMVYEHLPFICELFFKLIKDSIQSSSKLLSNKSIDLVDCKFRSSMYSVLSTIFGSFNKKISIEFKRYLLLELLGDFNVLHSPYLQINNSTSDLSIIGYGDDYGKDITDTINEIASLVLLIQHSVQLNSVLATDDFSVFVTQMISVSTLQSEDSYDNDFNVYITENTGLSGSVTVRDSINEFFSELNDKDSNAIFNAILRDLMSSTNDPWELTEAKFYILESMFQNEDTELEGDIDITDFYSFTVQFLALNEANRLNSNTNSLVIARVISMLPKFFEKFEGKLSVNKVSAYRDDIANYNNNIAAFIFSLTIFISCKLSSGDTGYDFIKASTLISSTNYRDLINFETDFNHTNSTSIQQNFFCLITDLLEASEEDALPVLLEALSVGININPKTASKTDASGSSVVDLILNVSFKDPSNVQSVIESSDCLRTLFENIEMADYITCCEKSLPFLINNINQSATDSQSVEYSPKLNLSLDLLDIVIESVPPNEINEKSFPEQVFNFLYSHIRRLVILANDDQILQSGGSIINSLIQNASTSFRTYKDPDTGESGLESLLTIVSKFLSSELSDRAALNCGTIVTSLINKFQQELGDQYLSQILAATAQRLLIAKEVITVENLVMLFCNLVLVSPESMINYLGNELILKDPVTGKDTPSLSLILPIWFQSFEVTRGYEKIKQNALALGKIFSLADQRIETLVVNGDLIPYDGDKIVTRSMTKSMPDRYTQISASLKILKLLVSELEFQCQQPNAEDYLQGKYEEDAGDDDGWEDLEDIGVPNYDKLKSYIDSDDEEHEESKDDDLKNLLIQFFKECAVRNLGNFSKYYGQLDDGEKRIITENVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B588</accession>
    <name>G3B588_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_98334</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686956.1">
        <property type="nucleotide sequence ID" value="XM_006686893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B588"/>
    <dbReference type="STRING" id="590646.G3B588"/>
    <dbReference type="GeneID" id="18250762"/>
    <dbReference type="KEGG" id="cten:18250762"/>
    <dbReference type="eggNOG" id="ENOG502RXUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054611_0_0_1"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="4"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="313" mass="36377" checksum="48427924BD0498F0" modified="2011-11-16" version="1">MHSHHSHSGSYVSHAVDDLDSVVAKAYVMGFTQFCLTEHMPRFDSKYMYPEEIVKGYDCKTLNTIFEQYETHARRLQLEYKDKMMILVGFEVEGADLDHIEHAVKLKSRFDMIVGSVHHALGEPIDFDEDLWRKARDHTDSKTSRELYKRYYEMQHTMIDKLKPDVVGHFDLISLFQPQDDVDPTTGKNVMNIDMETDWPEVWAQIVKNIELAASYGGLFELNSAAIRKGWATPYPKPVIAHAILDHGGRFCLSDDSHGMKQIGLNYHKVLEYVKELQLKEVYYLVREDHHTVVCSISTQELEKSPFWDQYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5H1</accession>
    <name>G3B5H1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_135056</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687017.1">
        <property type="nucleotide sequence ID" value="XM_006686954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5H1"/>
    <dbReference type="GeneID" id="18249840"/>
    <dbReference type="KEGG" id="cten:18249840"/>
    <dbReference type="eggNOG" id="KOG3841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299774_0_0_1"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TEA" evidence="3">
        <location>
            <begin position="252"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="947"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="947"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1036" mass="114041" checksum="8686A48388D5E7D4" modified="2011-11-16" version="1">MSPNPTIGASEVPLTPRTAGAQQRTSPSGGQNGNSNTNNIGSGYQRNLTPSYNFGFGFSPSFQFNSPRNLLSGLSPHRFFQASNNLTKATVGAKRDEKNVFNTSTPSRTSSKFLDSLSSANNTKNDSGEDSSTNSHDTEESAIWSVNEAESQNLTSLTISYDQTPIKVANKENENTHQRNFSGDFLTPNKLFLHRQDHSVATKKRRLSVEASPNTSIASRLETIASPPRSSKIFNRRRSSSNSSLSSKNSEDKVWNDALDDILISSYMKFKAFKKNTTSESYFVKNVSQNKVLSRMLLNKSGVLRTPKQIASRLFKITKSTNEARPGTHYLSSQNDLSHSHNILDESPLLNDGLDEIIRTPLEDLIESTSSHIDSVSSAEINAQIDKELDLIFSPNELSASPMLLLKSNRVEITDFQISYNSNRASGTHHFIKSNSGCNRTVELSTNSLLNRLKVSADESELSTKLCPKLVTQYESNDLLVFQAMNHLNLNMVSKNKFDTLDSVVLNANPLDLHNGSISSFMNLLVNGIESDESPLNWSCYTRIFSGSKLLFTSNDSIVGYSNGGNKFEATIPFLKHFWTGFLSLLINGNDDKDILKKLSILQIIHSNREDSKIEMCLIHKFDKLSRLGNSSFQLLKYSGKKEDLNDLAEEDEMFEETQVDHYSQSNDETNSAEDDNETVLVESSPVKAPEFHHRDLKIDIMAAKHSMAMGPASAPIYNPRLVQQMNNGIVKQESINMYPFTQHSQSTNDIPKYIPQPGYGSQMNGNNKAPLPYSTSTPDALSPYSNSFDGSRPMSFGSIQTSSNMATSTSYKGFPIGDQSHFQAPLPPSSVPGHQQIGQAQLRPESQRGSGASQGESQSHMNMSFMASGRQQLMVNVGSGYVPFGSLSQELQERYMGVQKQFELQQQQQIQQALLQQIQMNNLAGTNLQPHQGIAMNTGNIPLSAPASQTSFADPASKSYNTGQKKHSKPIKFGPMLEYDPSKDNAAAAAAAEAASAALAKAKARGESRPGVSVLNIPRDTPVYIYKPPKRKGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5U4</accession>
    <name>G3B5U4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(32) synthase</fullName>
            <ecNumber evidence="3">5.4.99.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_130798</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine(32) in tRNA = pseudouridine(32) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10107"/>
            <dbReference type="Rhea" id="RHEA-COMP:10108"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.4.99.28" evidence="3"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5U4"/>
    <dbReference type="STRING" id="590646.G3B5U4"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_12_4_1"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160151">
        <property type="term" value="F:tRNA pseudouridine(32) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000061">
        <property type="entry name" value="DRAP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000017">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="426"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="580" mass="65471" checksum="8835D130CD60E158" modified="2011-11-16" version="1">MADNIKPNSNKRPASIPPEDLRDSNGFRLRRQAIDKTSLTAYEQLGGDKHSDSINILNKSKTISEEETEGASYIIDGALRRVPPYFFTYLTFCKLRWRDRPLLDIFVDEFRDKDADFYKKAIASGQVTLNKKPADLDTIVRNGDLISHRAHRHEPCVSSKEIKIIFENENIIAIDKPSGIPVHPTGRYRFNTITKIFQHEYGKVVHPCNRLDRLTSGLMFLGKTSKGADGFVQQIKDRSVRKEYIARVAGLFPVEEITVDKPLRTIAPKLTLNRVDEKEGKEAKTVFRRLSYDKKSNTSIVKCLPLTGRTHQIRVHLQFLGHPIANDPIYSSEYVWGPNLGKNNEGNTDEIVSKLDGTGKDRAVSTWIHPEGDGEVMTGEKCTVCDSPLYTDPGFNDLELWLHAYKYEAADKSWSYKTTFPDWASQSTKGFMELALEEADKCGETQTQFNVGAVLVHDGEVLETGHTRELEGNTHAEQCALEKYQKRTRKPLPKGTEIYTTMEPCTFRLSGNLPCADRILETNISTCFVGVSEPDDFVKDNNSVSKLVSHGIEYIHIPGFEERAIKIAKKGHDKIETEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6L0</accession>
    <name>G3B6L0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_123844</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687287.1">
        <property type="nucleotide sequence ID" value="XM_006687224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6L0"/>
    <dbReference type="GeneID" id="18248984"/>
    <dbReference type="KEGG" id="cten:18248984"/>
    <dbReference type="eggNOG" id="KOG4127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_4_2_1"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="403" mass="45534" checksum="A1A7C4D69F355075" modified="2011-11-16" version="1">MGLFSNKNPEPKELDLDTLCKSHPIVDTHNDFPYLLRSQLHNEISNNPTFDFNHTTAHTDLTRLKKGKVGVQFFSCYIECKNPDKFYQDFNIPNSAVRDTMEQIDVTERLCKQYNLAMVHSSEDAWKRFKEGKFVVTMGVEGLHQIDMSLGVLRLYFQLGVRYITLTHNCDNPFATAASSVAGGLEDKGLTSFGAECVKEMNRLGMMVDLAHVSLKTMHDALDISRSPVMFSHSSAYALCEHGRNVPDDVLLKLKKNNGVICINFFPIFLKKEGEVTIDDAVDHMVYVINLIGWDHVGFGSDFDGIPSGPKGLEDVSKYPDFIKKVAAKTNGSNADLAKMMGGNVMRVWRDNELMAAKLKHEPACDENWDKREWAFHKFVKMFPEIFAGSMDAKQNTYSEYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6L2</accession>
    <name>G3B6L2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114800</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687289.1">
        <property type="nucleotide sequence ID" value="XM_006687226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6L2"/>
    <dbReference type="GeneID" id="18247585"/>
    <dbReference type="KEGG" id="cten:18247585"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_2_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="39"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="531" mass="59076" checksum="F53CBF594E19B2AE" modified="2011-11-16" version="1">MATEKPESLKSLESSSSVTSGRKKFDPVTGVKRGLKTRHISMMALAGIIGPGAFLGLSRALNNGGPVGLLVGFSIVGILVVVMMFSIGELNSMFDFNFNSHAARWVDPAFGAALGWNYAFLWVCTLISEYVAVTSTLQFYSEKVPIYGYYLILWFCFSLYQMLGVDVFGEVEYILALVKIVFISGFYLFAIISAAGGIKGHSPGNPFRDYPLAHGFKGIAKSFVYAAQFYVGVESLSVTFTESRNVRKAVKRAVSQSIFRIFYIYFGLSIAYGITVPWNDPALSDGSAILNSVMTIALVKAGWKNAGYYVTTVILVTCVSSINSAVYFCARCIMRLSVEGYAPKVLAKVNKNGVPWVACNLVHLFGFISLLSMDSTSSVAYGYIVGLSGVSAFIVWTGIIFTHFKFRKGWLQQGNSASDLPFKAPFYPYSNYLGIFVGIFLCLVQGWTVFVPFQAGQFVDLYIMLPLFPIFYLIFKFWKKTKWIRSEDMDFETNRIDHEVEVGEKNEDATETVVEVPSKKQKISKLIWNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6L6</accession>
    <name>G3B6L6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_135304</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6L6"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105919_0_0_1"/>
    <dbReference type="OrthoDB" id="4022214at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442793" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="228" mass="24099" checksum="FE51CF2AAE4601EE" modified="2011-11-16" version="1">MFSKSLKGLLVTAFSALLANAQDITSNTIDRGTISISLGNTHIYPDVYYSIIDVAVASFTGSFNNEGGFYLTSDSSLIALTASIVGTSITNSGDWAFNSIQSLTTPDFYLTATISFSNTGTMWFGGDGLGVPIMSVLGLSWENDGLMVFSLTTRSTGEVLLGAALGVGTQTITNEGTICLINQVYEQSTKIEGSGCIDIGEDSTVFLYPSTSLTFISSSHCRIAYSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6T1</accession>
    <name>G3B6T1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114319</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6T1"/>
    <dbReference type="STRING" id="590646.G3B6T1"/>
    <dbReference type="GeneID" id="18247371"/>
    <dbReference type="KEGG" id="cten:18247371"/>
    <dbReference type="eggNOG" id="KOG3488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150144_2_1_1"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="83" mass="9084" checksum="98A7797B0E8AC08F" modified="2011-11-16" version="1">MFDQLVGLAMLGVAVAVFVYYSTWVLVLPFVDDSSFLQSFFLPRDYAIKLPLLLLLIGGVAVGSFVGSVLIKESNKKKAKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6T9</accession>
    <name>G3B6T9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_130573</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6T9"/>
    <dbReference type="STRING" id="590646.G3B6T9"/>
    <dbReference type="eggNOG" id="KOG0879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="176" mass="19744" checksum="D4691AD9FE735DE2" modified="2011-11-16" version="1">MMSSNNNSNSDPVVFLDILQGNEPLGRVKIELFKELPRTTENFRQFCTGEYREAGRPTGYKGSKFHRVIPHFMIQGGDFVKFNGTGTKTIYGTDLFDDESFKFDHHKYSVSMANSGPNSNGCQFFICCKRLEHLDGKHVVFGKVVEGFEIVDRIEASGTAKGTPRDEIVISNCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B789</accession>
    <name>G3B789_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115056</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B789"/>
    <dbReference type="STRING" id="590646.G3B789"/>
    <dbReference type="GeneID" id="18247696"/>
    <dbReference type="KEGG" id="cten:18247696"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_13_1_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="143" mass="15796" checksum="A80B3D9069CC585B" modified="2011-11-16" version="1">MSQNTKTYKDAFALFDKKGTGKIPVEHLGDLLRAVGQNPTLAEISDLQSGIGGGEFDFETYKKIIERPDGFKPLGLPEDYIKGFQVFDKDHTGYIGVGELRYILTSIGEKLSDSEVDELLKGVNVTSDGNVDYVEFVKSILDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7K4</accession>
    <name>G3B7K4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115098</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7K4"/>
    <dbReference type="STRING" id="590646.G3B7K4"/>
    <dbReference type="GeneID" id="18247717"/>
    <dbReference type="KEGG" id="cten:18247717"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_1_1_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="174"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="373" mass="42293" checksum="E35F4F3F54857EC5" modified="2011-11-16" version="1">MSFNEIPSLDLSLALDPSTKPQFLQQLRYALIDVGFLLLKNYESVGPSPDDFQSIKHQTEAFFRLPQSVKDGCSMLNSRHFLGYNKLANEITSKHTDWREQVDLANELPAPGADEPIYRNIEGPNEWPDASHIPEFKPVVLNYISNMNRLATVFRKLVCEALEVPADSMDGYFKPNQQTKMKIVAYPDVSQLKQESSKSNVLDDDFSTGQGCGPHRDSDLLTYIFQVTNHQNSLQVQNFQGKWITVPFIPNTLVVNVGQTLEAITQGVCKATIHRVVIPEPGTGTRISVPFFQTIDLDSKKSMLDNIPARVLQLKEERDAKIKDWAVDTGFQFTPEIDKYPVGHYVFRNRIKSHQDVAAKWYPDILQDVLSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7X3</accession>
    <name>G3B7X3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115136</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687848.1">
        <property type="nucleotide sequence ID" value="XM_006687785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7X3"/>
    <dbReference type="GeneID" id="18247735"/>
    <dbReference type="KEGG" id="cten:18247735"/>
    <dbReference type="eggNOG" id="ENOG502S7XK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119130_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442566" description="Cell wall protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="10513" checksum="D7FA5A3BA7453607" modified="2011-11-16" version="1">MQFKTVVGAAALATLASASNVTVTTDIVVTDFTTYCPASTEFVVNNATITVTEATTITISGACTIPTTYVTSAPASSTVAPAVETATGAANKVVVGAAAGLAAVAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Y8</accession>
    <name>G3B7Y8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_115149</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Y8"/>
    <dbReference type="STRING" id="590646.G3B7Y8"/>
    <dbReference type="GeneID" id="18247742"/>
    <dbReference type="KEGG" id="cten:18247742"/>
    <dbReference type="eggNOG" id="KOG3457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133423_1_1_1"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="93" mass="9543" checksum="B2274C53D038D725" modified="2011-11-16" version="1">MSASSSSVAPGGLRSAAKRKTTAEKKAQATNANPVSTRSAGAGGSSATMLKLFTDEAQGLRVDPLVVLFLAVGFIFSVIILHVFAKITGKFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B852</accession>
    <name>G3B852_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_126155</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B852"/>
    <dbReference type="STRING" id="590646.G3B852"/>
    <dbReference type="eggNOG" id="KOG2229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009161_2_1_1"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="64"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="515"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="664"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="639"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="712" mass="80468" checksum="BACD57EEC95FD772" modified="2011-11-16" version="1">MAKKRRVAILPTNIILLQNVVKRDPESYHEEFVQQFAHYESLRDIFLTSPDSSNFQEFGDLVGFVSAVCNCYPKETAKFPDDLRQLLVNNHKDLSPELREKIIQCLTMLRNKDIISAEFLIQTLFPLLTAYGSTTAGQHAKSVRHQIYSTLVSLLKAVNMGAKNQKINRSTQALLFNLLEQRDAQGLWATKLTRELWRRGIWDDSRTVELMTQAALHPEAKVAIAGARFFLGADKEREENFEEQSSDDDVDMGALRHKMQINKKTSKRGKRLEQAVKAVKKKNNKNTQVYLNFSALHLLRDPQGFAESLFDGHLSGKNSNKFDLDQKIVFMNLVSRLIGSHKLTVLGIYSFFMKYLTPKQRNVTQIMAAAAQASHDLVPPEQISTVVRKIADEFVSDGVSAEVASAGLNTIREILSRAPLAIDVTLLQDLAEYRGSKAKAVTNAARGLITLYREVAPEMLKRKDRGKAASIEMQHTEKAKLPEFGVQNTVTSIPGIELLAQWREEQGLGTEDKDDDWEVEEIDSDEEEEIEEIEGDWVTVESDKEYDLSNDESDAEDASGKNAADDDSEPPTKKQKLTNEQAMNAILTSKVLTPADFAKLDELQMEAGVQKHMGIKTDDTVDGDSLVGTVKFKQTKEERLEHVKEGREGREKFGSRKGRRDAPHSTTNKEKARKKNFVMMIHKRSVQGKQKMSLRDRQKVLKAHITKQKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8C7</accession>
    <name>G3B8C7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_109227</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688535.1">
        <property type="nucleotide sequence ID" value="XM_006688472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8C7"/>
    <dbReference type="STRING" id="590646.G3B8C7"/>
    <dbReference type="GeneID" id="18246091"/>
    <dbReference type="KEGG" id="cten:18246091"/>
    <dbReference type="eggNOG" id="ENOG502RZGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053720_0_1_1"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="221" mass="25250" checksum="0131BDFBDB3A6F53" modified="2011-11-16" version="1">MSNSSNDTVSGSVPQLNTQVENSDVDQTSLRYAAYANRFRTILQASHRYVAYTSDIGESFRPVAHPFIVTIGYSISWLYILGDVSYASWKVKMKSEGRYTNNLMPWNYPYPEPNDTAKVLYEQKSESLVEQDWRLAFVKRGLFQSIASMGLPAWTIHNAVRYSSIMFKESKSKPLKTYGPVAVGLGIVPLLPYVFDEPVEYVIDYVFDKGEDFYKKSQKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8V8</accession>
    <name>G3B8V8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S19e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_124933</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8V8"/>
    <dbReference type="STRING" id="590646.G3B8V8"/>
    <dbReference type="GeneID" id="18249062"/>
    <dbReference type="KEGG" id="cten:18249062"/>
    <dbReference type="eggNOG" id="KOG3411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108559_3_0_1"/>
    <dbReference type="OrthoDB" id="4026135at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="144" mass="15916" checksum="E529F95E3D861830" modified="2011-11-16" version="1">MAGVSVRDVPAQDFINAYAQFLQRQGKLEVPGYVDIVKTSAGNELPPQQSETWFYQRAASVARHIYLRKQVGVGKLNKLYGGAINRGFRPHKHADASGSVNRRVLQALEKIGVVEISPKGGRKISDDGQRDLDRIAAQTLEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8W0</accession>
    <name>G3B8W0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_135725</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8W0"/>
    <dbReference type="STRING" id="590646.G3B8W0"/>
    <dbReference type="eggNOG" id="ENOG502RPU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473257_0_0_1"/>
    <dbReference type="OrthoDB" id="4026135at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="522" mass="59254" checksum="FE04A053FC24677C" modified="2011-11-16" version="1">MAATNKAMATNPRRCQLTASVASVNSSSTTTSLLDLAVDVLDRIVYFLTWGAGHRVTNHNPPFTFEPNSTLPGYSDALSLSSTCIWLREYLGPCLFHNCSLIRADQTDAILEVSSSQFNKDAVIGILETARYHSLHFRYPLFSFNNFVTYLECDKPVYDTFLRLFPRLQSLKFLDYPSSLTTVDISTISTVRSLSLNVVHLPLFASILSSLTRLDVFVDLHDAGPDHLVYLSQSLEMWNLTELNVFLKEPSSISYSLVVDIISKACKCSLTKLSLREIRRCYDGAVYDHYDLDKANGDAFIAAINGCKTLEHITIDVSILNYMTFTNITPQQPIVSTGRILSIIERSLFVPVFLQDFKNKLSSLIKSLGVSHINLQYGDPMSQSDLAALMTLKDFVNFFSETFLSSQINTVSMEQVWSIANEAAFRDYIHRKLYLEEPDLVSVSTALSPKSFLTLKPWHRSLVHTPNFRLYFEYSVDYSGTFFRPAVDPNTEISLDFWSVESSLMELEQYARRRRQRSNIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8X8</accession>
    <name>G3B8X8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_108836</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8X8"/>
    <dbReference type="GeneID" id="18246064"/>
    <dbReference type="KEGG" id="cten:18246064"/>
    <dbReference type="eggNOG" id="ENOG502R9QV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101844_0_0_1"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="238" mass="27665" checksum="0A2B3F00B8F24BA8" modified="2011-11-16" version="1">MLPPKHSLHPPKYKTAGEFTKHYNPPNYIYSDQLPSKPTDIRGIDSSGYTYLNQSAYHKFPVLSSNEYLQLKFFPGNHFISRIRKSNIALGNFNNPISLLNDPVLEKALKSYRGKYSESGFFNERSHPLSTAVGRARYKKFVKQCLFESVIGKDVTRVRGFYFVRYHKVPVTEQDKASLKEYISNAVSRINNDDKLYQSLVRTSQSLKTPRDLKKNAKLYNWYGAKWEPTYYPKLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9C0</accession>
    <name>G3B9C0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sec63-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_125106</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B9C0"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_1_0_1"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="385"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="580"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1232"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="2022" mass="230413" checksum="5C7CEEE3A2CDFED0" modified="2011-11-16" version="1">MGSHAVSENLNSETKSVSKANNISTTNTRFQASSIASIENLSYYPTTDENSDFLNDLMIQVHHKLTDASHDTIVSATDVILEILKNDEMSVTDKRQEIDSLLDTKVTDVELNDLINLGKKITDYRQHEQADDNQEGMAIVFEEDEDEEENVAEAEAAVEEEDDEFRSPVPVAESTAGEDDYIDKKLVDVEKDVVDDFKVKLADLELSGSDLEGELSNIVKDTQILHHLLDNRWKIVFKMKFIRSGYESIKQQLVDLNLLELIEEFNELMAANNKKRRLSEDNVDKSTKSTKIEKRIPKRIDLEALVFDQGAHLMASTKVKLPKGSYQQNKKLYDIVSIPAPEIPDEVIEARKNLVPITDMPEWAQEAFPSGETATLNVVQSKIYPMAFKTDENLLLCAPTGAGKTNVAMLTILRTIENFRTESGQIKLNDFKMVYIAPLKALVQEQMREFQRRLTANYGVVVNQLSGDSNLTKQQIVETQLLVVTPEKWDVITRKSTDLSYTNLVRLIVIDEIHLLHDERGPVLESIVSRTLRQVEETGNNVRLVGLSATLPNFEDVARFLRVDMEKGLFFFNATYRPCPLEQKFIGIKEKKAIKKLAAMNEACYEMLTDSILSNQQLIIFVHSRKETFKTANWLKNKLEEEEKLDSFLGSSLGVKEILKSEADMMLNKNLQEILPSGFGIHHAGLNKDERTVVEDLFAQGHIKCLISTATLAWGVNLPAHTVVIKGTETYSPEKGTWVQLSPQDIIQMLGRAGRPRYDKSGEGVIITSQDEIQYYLAILNQQLPIESQLMGKLADNINAEIVLGTISSLEDAVNWLSYTYLYIRMLKSPALYHVGAEYGNDENLYYKRLDLAHSALMVLQENNLVNYNPVSGNVKATELGKIASHYYINYRTMNMYNNHLKPWLTEIELLSIFASSGEFKFIPLRSEEKLEVSKLYEKVPIPIKENSTDPLAKVNVLLQAYISRLTLEGFALMADMIYVTQSAGRLLRALHEICLRKNWASVSKTTLDLCKMVEKRMWLTNSALRQFGSSVSKEIVRATESSHVPFVNYFTLSPEALAEAVNLKGNSRRVHELLKQFPRLNLSYYAQPLTHNLLRVQVEVVPNWDWNPSVHGNFQDFLLFVEDCDGDKILYRDKVSFARSSENKELLVEFTLPFLDPVQPNYFVSFINDRWLHSEYKIPLMISDLKIPKKSPNFTKLQDQPNVLTSEVKVPDFIETFDFKYFNKFQSQVFQSLYNTDDNTFIGMSKGSGKTVCAELAILRHWKNNKGRILYLQPNEQAVYKLTKRWKKLYRSIGGEGKEVEKLTGELATDLAILSSNHLILSTPEVFDFVSKRWRQRKAVQAIEMVICDDVQLIGSGSSGVSYENVVARMKFISSQLEVNIRFVALSSTLANGRDFGEYLECPRQSIYNFEPSERFHKIQEIVIQGTNFGDNRTMLLNSIKPSYTFLKNNTGQGKSLLFVSSRKNCVEAAYNIVQNAENDSWKLLRSDVASIESYLNKVKDHTLKELLKRGVGIFYPDMNSVDQLVVERLFESEVLTVLVVAKDCASFCPPANHVVVLGTEEYYGREHRYVNFPINTVLEMIGCCSDEMGQSKVMIFTRNATMNHYSKFLNEGLPLESYYNSMIHDIFITEVSNRTFKERQDCVDWLTFTYFYRRLQMNPSFYDVKDTSHMGISEFLSDLVEETIKDLTDNNLIELEEAEEILSPLNGALIASHHNVSYHTMVELNKLDNKTKLRGILEIVCSAAEFEELPMRLGDSTNLQKIYNQVPVKSSNPDFESPYFKTFILLQAHFSRLQLPLDLRADLVFILKQVMKVIGACVDTVSSEGYLNAIQVVDLSQMVIQGIWNRDSPLKQIPHINEGILTRCKKYNVETVYDIMALEDDERDDVLQLEEAELEDVAEFVNKYPNVDISYELEESVVANEPVMVTVNLERDEEMEDLSVVSSVFESHKREEWWIVIGDAASKQLYGIKKTSIAKESQTVQLEMTIPSSGKHNLTIWCMCDSYLDADKEVSLEVEVQPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9L7</accession>
    <name>G3B9L7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_99040</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688094.1">
        <property type="nucleotide sequence ID" value="XM_006688031.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B9L7"/>
    <dbReference type="GeneID" id="18250817"/>
    <dbReference type="KEGG" id="cten:18250817"/>
    <dbReference type="eggNOG" id="KOG3613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001197_1_0_1"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="353"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1229"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1319"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1331"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1707" mass="195492" checksum="600239A57A356F53" modified="2011-11-16" version="1">MEKKGLSKVLPAFRAKSATETSQLSIKDKRYYQQVEKSLLSFESLEEWADYIAFISRLQKALSLPQDQRSFHTVELIPYASEVADKLSLCLSSKLPNGVHQKALNLYESIFLSLKEDVFSNEINLWLPGLLPVLSFGSIQVKSEMVKLFKNHILSNINSKNLKVVAKPMILSLLSGLDDENSESFPDVFELMDTLKLKLESDSHYWKCLFLAIITNPEKRLGALYWCNKRLPMFTTIKTETGGFEYSYEAQACIDPSPGLLIRAFSTAINTETIFNPANDIIIIRGFFDLMLTHLPLNSSVFARSPKDKDLLVKSCIQILLKKDMSLNRRLWNWLLGPDSDQLVDSTKVRAKYFEDFGLEPLSRVLLDLVHDEKDTNKQIDSIKMALSLIIDKWEISHMVIPKILRPILSETYNKSKSSTTRFSEVLSSSQDFFNGIESSYIWNLFIDLIKSSNLDLLEFILSNFDINEEEMKVTHAPLALMTLLINFQEEKNWFNSVSIVIELISPKGLEPVDKSLTSKVDKEDVSKKISNFYGELTLDEEASTPAFTKSETSFYLYFLFKAIIIENFTSINSCRLCELFEKLVYTIPISDSFKARDEDILSLMLKQTNISHSPTTETQNMNTIVAFSISKLFHLLSSELSTLEKTRIIKVITTNLWPSLVSSDPTQPQVESVKCLFDLIINSSRYYVEPAISSLILQSSHNDRVKAMTCLWSHSNSNETDSVLEIPLKLVLDDLFDESSINKLQVNEFIRTIIKSGHSNRLLKMITNPLMDFELMATHKSEIEVDDQLAEFAYHLGTILHVINSNPKNLKEAFNNEFAVMDNSTKLEISKSNEWDISTYKSLIFFVIEKFLSLRLSEDVLNEGGCILKDYYNCVDYCLELLTTLISGNEPDFTMKFHSLIDNCFYYISLPTVPYQIELAECQYLKCIFHLLKLSEDSKINLNLLHIDDQEKEPFLVRFIIKGISKSQISVLLQQYMILLTRSLYLFNESVFSVLSLLNSAIIEKINDYFNKIVKEETIGILVDFEASINELISGLEDLLSISHSYLLTSKFRNKSDSKAANGQQDSSFLGNVIQGVFSIESPAVRTSEQNKLYSILLAFQDTIEMIFKIWKWADSKSKLYEYKTEDSPIGSHRSIIHLGNKLKFRSKKLFESLMDLERQEVIENLIAADPGYKSSIKLLNLLDGGRSQITLPNIFNSIMTRCYPSLLDESKKSHLNVSITEKELSRFLIFYFESIDTDTITDIWSFSTQFFKDVLAHHHHFKQLIPNLLRVISKLSLKLSNSKFGSDKKHKRELRDIFSKLLGVSVSGKRILFSSSEEPANGTINNEENNSEDDEDESTTPQGVQDELTDALSELMENFEEVIQDSEKLSSCINVIILNFVSPQIKNKKINEIPLRTLTLVKNIGQYAPNRTWKSLIYDLFMDSNFFKLPANRLEIWKSIISSWMSVETEKFNELISKVSATGSGSAGTLFMFNEKAELENKILTIKRLSFIMLTQPKDFFLSSLDDLFDQIEISLMNNVPLSFKTHISILFRVITIQFNELYLLPRWIVMCQQVISIFENILNKSMKELSFLSEEELQSILYGCKLLDQLLLLNNDEFNMQDWLFVHTAFDVNSDIEDAMVSIVDKISQEYDLTILKESPVKIDPLSPDNKKIPLLKGVTSIKSIANLKSFFESLSYLNFERVYGLYDTDFEACEADIMEDLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9U6</accession>
    <name>G3B9U6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115426</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688898.1">
        <property type="nucleotide sequence ID" value="XM_006688835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9U6"/>
    <dbReference type="STRING" id="590646.G3B9U6"/>
    <dbReference type="GeneID" id="18247865"/>
    <dbReference type="KEGG" id="cten:18247865"/>
    <dbReference type="eggNOG" id="ENOG502SCJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145563_4_2_1"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="81" mass="9049" checksum="E93A56E85BAF4BE2" modified="2011-11-16" version="1">MLARSFARQSVRSLSTTRVVLSSNEGATAAGKDAFSDRERAQETAYVKKHEAEQLKALKEQLAKQKETIDQLAQEIKSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9V3</accession>
    <name>G3B9V3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_135908</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9V3"/>
    <dbReference type="STRING" id="590646.G3B9V3"/>
    <dbReference type="GeneID" id="18249918"/>
    <dbReference type="KEGG" id="cten:18249918"/>
    <dbReference type="eggNOG" id="KOG3790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018580_2_0_1"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="539" mass="61980" checksum="F90B79E215D8EA10" modified="2011-11-16" version="1">MKRRSKKDDGSSLTSTIKTHSILGDVWVPIYETPVEFSSSHFETAMLNIIKQPNINSTVIMRADILKENIYDPEKGDTMFVSKNIKTLPSFPDQDESDTLLYRNYDDVELRHIPLDDSAIKFKPKCQVVRRVIPRNPFKDYIINQTSVILSDDSNRSLMVVYIPHIEKEDETPFYLPPVHGIAILFHDDKLSIHYLPFNYTDPSERSKLRTLDPNERSIRIAMRLLLTSRKHSQGSKDGYEKRVVHDLVVPKEAFQNRYISLKKKYSSALVNSWAEKTDPKKHVFEDLAIAAFLIELWKLKYDGRPFEFMDLGCGNGLLVYILHMEGYKGRGIDARARKSWITYPAETQECLEEKIIIPHVLLKSNTQKDKYFQIPDSHDPTLMTYHSSSKLMASKNVCITNEFKENTFIIGNHSDELTCWIPLLGYSFLVIPCCSHSLSGAKKRYTPKSSGALSTYGALVEHVEELSKTMGWIVEKESLRIPSTRNAAVIGFNKHSKYKDDTQETFDSRVMDVANREKNLDSWVENSISLMKKAPRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA42</accession>
    <name>G3BA42_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA42"/>
    <dbReference type="STRING" id="590646.G3BA42"/>
    <dbReference type="eggNOG" id="KOG1455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_5_2_1"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="39"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="299" mass="34439" checksum="A3D3FAE71399314A" modified="2011-11-16" version="1">MTAVPPIPYSPKKEPKVEFIPFDGLKFKTVFWEHTGTYKGRILFVHGFSEDSLIYTEFFDRLSDLGFDIFFFDQRGAGETSDTKDIGKTNEAHTFNDLDFMIKKNLEITPHKDDKLILMGHSMGGGIILNYGIRGKYKEYVKTIIATAPEVLLHPSTSPNFILKGFGTFASKYLPNVRIDAGLNYDYITSNEKWIKYIKGHNKKFWITGPLFMGMLERGEALTKSHYVAKFDPDISLLVFHSKNDHVNWYEGTKKFYDLLNDNVHKELVSFDDAQHSLCIEVDKYVDQLLEKIVEFTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAR6</accession>
    <name>G3BAR6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_131515</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAR6"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="33"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="483" mass="54888" checksum="DD3D6F7CBA46A294" modified="2011-11-16" version="1">MTSQESITKKDQSVVDINEINKRKILWKCDMFLIPFLWLNVTFAAMDKVSNGTASIYGMQTDLNLVGNQYSWIGSSFYFGYLFWCFPSSVILQKLPVAKVAGCCFFVWGIILIGSGFAKNFQTMVACRVLLGISEAPIVPINLIIMSIWYKRGPEQSIRLGLFYTGLSTIFTGTIGYAVGGYTDVKYSPWRYFIWIIGSLSSVYGLLEFFLLPDSPVSCRYLNEREKAIVIDRVRKNQTGVKNTKFKKEQFFQTFKDPKVWIMVAIQLFISIPNGGLTNFSPLIVNGLGWSSRDSTLLTMPTGIMQTVSVYMASGTLALLEKFFKKKHFRGAVLCFYLLPAFVGTGCLYKLPLTWYRSRLVSLYFGFFYLGSYIISLNLIAANHAGFTRKVTANAIYFLTYAVSNLIAPQFFKTSQSPTYTLGVAAIFGAYALTIVSVLLYMVVCWRENKRRDKLYGEAPEENRETDFSDMTDIDNINFRYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAS5</accession>
    <name>G3BAS5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115545</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAS5"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042860_3_0_1"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="129" mass="14865" checksum="AB4E6E48D1C57C7B" modified="2011-11-16" version="1">MFGTENQEIEQYNTSVDINKLPMFTRPELAAYDGSHKPEIYLAIRGFVYDVTSNPKNYGPGKSYHKLVGRDVTRLLGLNKLVIRKDGDEAVDTWSTDDFSDKQHQAVDKWIQFFRKRYRVVGLVVGHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB16</accession>
    <name>G3BB16_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115581</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688953.1">
        <property type="nucleotide sequence ID" value="XM_006688890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB16"/>
    <dbReference type="STRING" id="590646.G3BB16"/>
    <dbReference type="GeneID" id="18247923"/>
    <dbReference type="KEGG" id="cten:18247923"/>
    <dbReference type="eggNOG" id="ENOG502T74Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091756_0_0_1"/>
    <dbReference type="OrthoDB" id="4091959at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12622">
        <property type="entry name" value="NpwBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="199" mass="22998" checksum="9FA1FA2C512D9A04" modified="2011-11-16" version="1">MIRKNYSLAAELKKQESKKQNKIRARQKQQHSLDKLKNTDPIALYKKIQRLKENSLDKQDKYLKGLEADWQFILKNGLHKDKVEGFLKTVEKESAEREVLRNKLWGSQSVYFNPELNPLGKVPDPQRLPPGITTPIGNHTLPLKPTLKKTYAPDPIIEQLNITPPEGAPPQFYKQVYNTGRHHVTSIESDDPPKRFRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB20</accession>
    <name>G3BB20_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1014-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115584</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688955.1">
        <property type="nucleotide sequence ID" value="XM_006688892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB20"/>
    <dbReference type="STRING" id="590646.G3BB20"/>
    <dbReference type="GeneID" id="18247925"/>
    <dbReference type="KEGG" id="cten:18247925"/>
    <dbReference type="eggNOG" id="KOG3223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069723_1_1_1"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="115"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="224" mass="24559" checksum="9492E39050CF20F2" modified="2011-11-16" version="1">MAKKGGENSKKAAGNAKKADAASKKQQAALAAAEAEEASQWDQGSKKGNKKKEDEQFKKEEAARKKAEREALLAAEEASLPSKPQNSKQRGAAKVAAKRTGKIDDFMDFNSSKPELAASGIDNALEALTLTTKDGGLQNKDFDKHPERRVKAAFLAFEEKRLPEMRKENPGLRLQQIKNLLHKEFSKSSENPMNQATNVSYNATTDDIAEAKIAVRAKKEEKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB63</accession>
    <name>G3BB63_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein YTP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_115616</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB63"/>
    <dbReference type="STRING" id="590646.G3BB63"/>
    <dbReference type="GeneID" id="18247936"/>
    <dbReference type="KEGG" id="cten:18247936"/>
    <dbReference type="eggNOG" id="ENOG502QW3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012543_1_0_1"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833547" description="Protein YTP1-like C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="78"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="288"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="64752" checksum="BF4E3BC9C8812DCB" modified="2011-11-16" version="1">MLLHLQFRCLIPIALACASYVAAHGDEESHDMPMPAMVSSSSPSSHQTPVPHVMHHMHGVPILQTNLQPLEKQFWDAYNATSYLSVETGNKSAFFTYLATMGLAFVFATPLIMVMKNVQGVTPGYVTALVANTAVVLVGLFNYKLFMSSVPDLYPGNIFGVFNGIYFVTMIAQCIVAVIAAVHARRTAGASYESIDSDVDSLSSPSPTLYDLSRNQSPSSFELDSYPVNSEPHHDLEANDLTVHLNLLKKRPFPALFAKLNDNPWVVRSGAAATTANSVLAWFNFLFFLVYVPTAIAVFGCFGQGNKVFNLLAHFIKGGVFFILGLVTIARYCGAWSHKGWAWNHKLVRERDLRSRWVRLSPKGLITMEWIESFLVFFYGSTNVFLEHLANPGGEWSAKDLEHASIAFIFIGCGLCGLITEAKLSNWRHQYANFDDNKTVIKASPGFSPNPFPILCIFWTGTLMSQHQQASELSTAIHAQWGSLLAYGTFFRFVTYVMTMVLPRPRDLSKPTQPITEIIAGFCLLAGGVIFMESCDPVILALEWRGYGAMFTLNVCLGLVFLLMAWIMSVFQFKTWLQRRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB86</accession>
    <name>G3BB86_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_107875</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB86"/>
    <dbReference type="STRING" id="590646.G3BB86"/>
    <dbReference type="GeneID" id="18245986"/>
    <dbReference type="KEGG" id="cten:18245986"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017043_0_0_1"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="194"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="848" mass="93933" checksum="B388DACF31D936DC" modified="2011-11-16" version="1">MSAFDYDGYNNDFFDFDNTDSLLTSLSGPASNDSNSNNIQSLSPDSMSGDDWATNKWYANQPTNNFSSNNSSHNSTNDYSSDPSYNNTNANIIAQTVNPNLGEFDNSYQQTLFDDFNNNYSDAMHSSGSSQNDSSGLTPLSQQYSSAQTSPENIAKAESDDDFPKKGARTQGNGERKTSGVKINAKSNGGRVKRDKASHNVIEKKYRTNINTKILMLRDAVPSLRIASGVPGVSVADLEGLTPAAKLNKASVLTKATEYIQHLEKKNEMLRQQNSHLQRLIQQANLNANSLQVAPVPNRIQPTARPQPMSQMSSSNEYTDNSVYNNSQNYSIPPQENKPNKYFLGGMAAVMGTSLLGGPDSDFRGLSAIPFMPMSFAHPPGAVAQLWYLSKLLFFLGCLASWVLPNLFSLDLSSASKEKKVSGSLVKSWILVSLGLQLPSVIDEGKKASIIQKLLGHAQYEWTTLIGDYIYLSSCESTFETCFLNLLIGSLLLQKMPALTKVLELGMNLRFSLLLNLDYKGTDKSLVGLNKLVKDLDGICLFKNESMITRLSNLRDHLPINAGIERGTSLLKFVEVYKQNGDNLYKLVLSWRVLQIVDELNTLYLENSLIEDDEEQFCQNNKLFKDVNLIGELLEAGSTDVELSSYLTLFKASLLPKENTQKLMTSIKSKVNGALDQFNLSLNGLELTDDEEISDDEDEESERQGSETNQPTEVNRFKDQTKLINSLGVVSEEELIILTCGLIQTYYSHGKRAEAAQFLKHLKFKSDKVPLSVLAFTSIYQVVSLLVKEETISQEPDNGVILDQAVRVARLWLNDNDVMTKELRAKIADVIVAKGKLLNGCDDQVSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBE8</accession>
    <name>G3BBE8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_99232</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBE8"/>
    <dbReference type="STRING" id="590646.G3BBE8"/>
    <dbReference type="GeneID" id="18250839"/>
    <dbReference type="KEGG" id="cten:18250839"/>
    <dbReference type="eggNOG" id="KOG4442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008492_1_1_1"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="20">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="109"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="436"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="506"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV62172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="721" mass="82668" checksum="7FBE5BD8D3318D23" modified="2011-11-16" version="1">MSESEDDKQQQRRTPPVFLDCESATEEALQTFTQITACSYQNKSIGDSGQNENMTCDCHEKVEETTNVNHACGDDSGCINRATSVECMAGACNCGDRCQNQRFQRCEYAAISVFQTEKKGYGVRADTALDEGSFIYEYIGEVIDEATFRRRMVDYDSRQLRHFYFMMLKKDAFIDATEKGALARFVNHSCSPNAYVDKWVVGDKLRMGIFAKRHIARGEEITFDYNVDRYGAQSQPCYCGEPNCIKFMGGKTQTDAALLLPDGISEALGVTPRHERQWLKENKHLRTKQQNNDATINEAFVKSVEVSEIEEQDVNRVMAAMMKSHDANINRKLVERIYLTDDENVNRQIVRMHGYKTLSALLKSQTTDPDTTVKILKVLAKWPKMTRNKIQSSQIEDVVKDIRAHTNNREIRSLSVALLDEWGKLQMAYRIPKVSHSDAGQISYGRNPRSSSPEKLQDPNPVKHEEPEPQDPSSQTELPPGWESALDPNTNTMYYFNRDLGETTWERPQVKPKLKLKPVPVPRGPRQDSPPQRSTNNYNESQIAEMEAQRLDQEKQMLWQQNLNKQKSLQELILQSQREAEERKAMDLRLKQELTDKARARAKAKSKVKGSKSSGTTSSVEKRWSSLFAKYVPNLIKKHTEEIGKDNVKQCAREMVKVLVMKEMNKDATREPPADFEKSKLKQVKEFTGSYMDKFMIKYRQKHSKRHGEETEGTIKRTKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBQ4</accession>
    <name>G3BBQ4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligoxyloglucan reducing end-specific cellobiohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_99259</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BBQ4"/>
    <dbReference type="eggNOG" id="KOG3511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000700_0_1_1"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442836" evidence="9">
        <location>
            <begin position="23"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1276"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="10">
        <location>
            <begin position="46"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="10">
        <location>
            <begin position="633"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1410"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1419"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1441"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1452" mass="162099" checksum="51EF9FE80F2370DD" modified="2011-11-16" version="1">MRLPGNIVVLLVALLYLPFAEGKFEPKISVNRESSVAQEYLYLEDSPNVLVLRDLKVSISTDRGNKWGPVKGIDDNDSIFFLQRNAFDSSKVYASTTGKTHYYSSDKGLSWKKFEIQIKEGFDIVEPPRFLPNFKDPAKVMVEYIQCAVVRNDKYNSKSKVTLLVSKDGETFNAADLQSEVAYGAMNFLPSSASGLFISVTPFTNFLSMGSYSTVYASDSSGLRFKKVAENVANQEFEKIQTIDGVWLSDVFGKDSKDTKDKPSLIDLIMGGGADKDVISQISFNDGKDWNPLKVDDESCTGDDCSLHLLTSSQMDGEGKFVTGPTPGIVLGVGNTGKKLDHGFEHMRTFISRDGGASWKQALDKPCMYSFGDLGNIIVALPYFGKKQGSTNTLYYSLDQGLSWDSKELDVAFFPLSVSTTVDGTGTHFLITGLIDNTPEKTGDYDFSEVLYSLDFSEAYDKKCSKDDFEQVYARVAADDKKPLCMYGHREKFKRRKAESKCFAATLYEDVTVYDESCDCSDQDFECAPGFKVSKKGGSCEPDKKVIGEMCRTQKVKELSLPDKVLADGNECSIGKKSFKQFISEHKLKCSDYIDKDDKDKDKSKKIEVSKFSFEGKMTEYTYFEQGDDYRGENIIVRTSDNRLYASRTGGTKFVKAPMYEEVLAYFMGSVPGQIVLVTNSEIFFVSTDAGNSYMRYKAPSRLSAQNPYVSFHKESVDQFIWYGANTELGCGDIFSDNCKSTAYITTTGGEIFTTLREDIVKCDFVGPILKEAEKSENLIFCSVIDKESKQLKLVSTTDNFKTEKVLAKGIVGYAISGNYVIVGAVDDKEGTLTAMVTVDGSTFAKAAFPRDLNIDIKQAFTVLDAATGSIFMHVTTQSKKGDEYGAILKSNSNGTSYALTLDHVNRNTVGFVDYDRIQGIEGILVANVVSNYKEDSEKKLKTMISHNDGGEWNYIEPPTVDSKGKKYKCGGKTIKDCSLNLHSFTERADYRDTFSSPSAIGIMIGIGNVGSHLTKKSTGDTFLTRDGGLTWKEIKKGAYMWEYGDRGSIIVLVKDGKTNELSYSLDEGKKWINFKFADDEVDIKDLATVPSDNSRKFIVFAEKDADSVAYTIDFTDIHQRQCQLDLDNPSNDDFEYWSPKHPNGVNDCLFGHEAKYLRRSSSHTDCFIGMAPLSEGFKVTKNCSCTRQDYECDYNYFRDGDNTCKLVKGLSPSDHKKEMCKNDAFQYFEPTGYRKIPLSTCQAGKQFDAFVPQACPGKTKQFNEYYGRDVGIGKLLLIIGIPLAVFIFATWFVYDRGIRRNGGFKQLGQIRLDDDELDFHPIENNSVDKAVNSVVRGGIFAVAVVIATFKTLRKVDKAIFERVVSQVFGGGAGRRNYVSVPDIDNDEEELFGNFRDNYDDELEHGDTEDFHQQFSDNLNEDNGFDNEPAEIDSDARLFDIDDQSDEEPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBU1</accession>
    <name>G3BBU1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTEDRAFT_115704</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBU1"/>
    <dbReference type="STRING" id="590646.G3BBU1"/>
    <dbReference type="GeneID" id="18247974"/>
    <dbReference type="KEGG" id="cten:18247974"/>
    <dbReference type="eggNOG" id="KOG0287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028491_2_0_1"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="term" value="P:DNA damage tolerance"/>
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        <property type="term" value="P:DNA repair"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Rad18_fungi"/>
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        <property type="entry name" value="Znf_RING"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9 17 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 17 18" id="KW-0234">DNA repair</keyword>
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    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="22">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="21">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
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        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
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        <location>
            <begin position="362"/>
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        </location>
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            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV62239.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="422" mass="47707" checksum="3785020496223BDE" modified="2011-11-16" version="1">MFDPFAKNLADVTDPSEWKPTKLPMLSQLESLQRCYICKEFLSAPVLTSCNHTFCSSCIRQHLMIKNTCPLCLSNQLESNLRRVVVLEEIVNCFKSLRPFLLDFLQPPSNDSVSSTSDRTEIRSVPKRKLPSPETSSLPDSDDVIIISEEDEPMKRTKLSADEAECPICNKKMEPEFLQNTHIDNCLNGHSDVLPKEKPGGGKKGISAFFKPRAKNNESNSAENALKINHSDFYFNSAEKHVVKEIRLAKLDFNSLSVPKLKEKLHAIGIPTTGSRHQLELRYNQYYILFNANLDSSHPVDVRVLRQRLSRWESSHVAFTNAGNGSIFGGRMSTRSITDKQFSVTEWQQAYHQDFKELTRRARANTQRNLNLKTRTTLESEDSNTHPKPSQGLEGYTPLDSNDVVKEDSEVETSGKKMAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBU6</accession>
    <name>G3BBU6_CANTC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116103</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="79" mass="8841" checksum="B3AFA78733AA972F" modified="2011-11-16" version="1" fragment="single">MGVDVAEVIDYGIRRDKAYNSTITGETAELRPIWNKDGQPPSVELKTISVVRELAGDDVNRCLTHYGIDSYSNHKLGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCD8</accession>
    <name>G3BCD8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fumble-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_137280</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50310" checksum="FE36B17433C814DF" modified="2011-11-16" version="1">MSPQDQINLDVVGRGTIRIDCSGAYIANDQLVAASDEPASSTSPSPENSDPEFDNDPNDPEDITGIPHNITLPKHNSEVIHISVDIGGTLTKLVYFTRSKKINHQLKGGKLHFKDFQTENFSTEVLAFMLKLIKRSLDKEKLPPITYIMATGGGAHKFYATMTKRFAKNKLPVEIIATDEMECLIKGLDWLITKIPNEIFIYDLEDNETKFISSPYTHDQQIYPYLLVNIGSGVSMIKVTGPGPNGFERIGGSSLGGGTLWGLLSLLTEAKDYNEMLEMASRGNNENIDLLIRDIYGGSYNKIGLKSNHIASSFAKVFKKLRFNKDLSTSTPAEKLAQFKGEDIARSLLYSVSNNIGQISYLQALRFNLKRIYFGGSYISGHKQTIHTLSYAVNFWSQGDMKSYFLRHEGYLGSVGAFMMGPGPREDVNGTGTSRDMTSRDLTPTDHHTHPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCP6</accession>
    <name>G3BCP6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_109917</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCP6"/>
    <dbReference type="STRING" id="590646.G3BCP6"/>
    <dbReference type="GeneID" id="18246152"/>
    <dbReference type="KEGG" id="cten:18246152"/>
    <dbReference type="eggNOG" id="KOG1099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_1_2_1"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000176">
        <property type="entry name" value="tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="299" mass="33837" checksum="D5EAC90C58BE94CE" modified="2011-11-16" version="1">MGKSSKDKRDLYYRRAKEEGWRARSAFKLLQLNEQFELFKGISKVVDLCAAPGSWSQVLSRELYEVQKNPNGQIVAVDLQPMTPINGVTTLQADITHPKTLQRILDEFHGELADFVCSDGAPDVTGLHDLDEYIQAQLILSALQLTTCILKPGGTFVAKIFRGRDIDLLYSQLSYLFEKVICAKPRSSRGSSLEAFIVCLNYRPRPEWVPKLELDKSTEEFFEDANIGKSKNLEFLDLPNDERVIAKFIACGDLNDTDSDATYTLEGRREVLDPIQMPTSPPYKQALEMKRRGALVRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCU3</accession>
    <name>G3BCU3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116263</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in protein synthesis. Involved in microtubule stabilization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690265.1">
        <property type="nucleotide sequence ID" value="XM_006690202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCU3"/>
    <dbReference type="STRING" id="590646.G3BCU3"/>
    <dbReference type="GeneID" id="90981854"/>
    <dbReference type="KEGG" id="cten:90981854"/>
    <dbReference type="eggNOG" id="KOG1727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095877_0_0_1"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="167" mass="18569" checksum="A3F48A554A3FE8DF" modified="2011-11-16" version="1">MIIYTDFISGDELLSDAYDVTLVDGVIYEADCDMVKVGGGDVDIGANPSAEDGGDDLEEGVETVNNVVYSFRLQNTGFDKKSFLTYIKGYMKKVKAHLAEVNPDAIETFEKGATTYVKKVVSSFNDWEFYTGESMDPDAMIVLLNYREDGTTPYVAIWKHGVKEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDL8</accession>
    <name>G3BDL8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_95780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689547.1">
        <property type="nucleotide sequence ID" value="XM_006689484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDL8"/>
    <dbReference type="GeneID" id="18250540"/>
    <dbReference type="KEGG" id="cten:18250540"/>
    <dbReference type="HOGENOM" id="CLU_1320736_0_0_1"/>
    <dbReference type="OrthoDB" id="4078061at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="208" mass="23937" checksum="6D01A7EF8C26FF10" modified="2011-11-16" version="1">MGNKASTARKLQSEVSHKSDSFVRSKVNQLPSSELKQKFIDQQQGPKPNVPQVEGKDGFDPQMTRQESRDFIDTITSLGRVIESSSDVPHKQDSVSIDQLKNRKKLETSTQEFSAQQLTALLNEIHDLRYTKEQVLKDYDLSDSWLLTLNRFKVANTYKEFKEHKKDEITHHGIFEDKTLIDEELLRESRLSDESSAKALEDRISVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE16</accession>
    <name>G3BE16_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_127665</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE16"/>
    <dbReference type="STRING" id="590646.G3BE16"/>
    <dbReference type="eggNOG" id="KOG3437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025279_0_0_1"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="406" mass="45256" checksum="1178FE683BF93600" modified="2011-11-16" version="1">MNSSGRWDRSPPFPEPTTDISDVNHVYNSANGSGIHSVDVSYNPNQTPQHELQTQDAIPESELIDSITSANVSERQNPFLDDQDNYHSVEVNDEESTNKSDILEEPTMEQIQQVYYARGLKEIESLDLHDLSPLANWKLSSLKQGFGLAQLRDDTPNMYWQSDGSNGTNNSNSSNNGAITNNQLSNPHSITIQFSKRVSLERISLFTNYNLDESYTPSKIKVLAGSSDGWDLSEVCTVNFSKPVGWSHIIFSGIRNDRVLKCFMVKLVILANHQDGKDTHIRALKCYGKKSSLNNKYMSDNGNHNLTDEEVLKDLSLNSAGMSNSGLSLNNQLSLSYENRLRYFMHSNSNIDVNNTNDDTDQEDDVDDPNLPIDQETSRILGNASDVIGFNTGFSSVSLKSVSSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEA3</accession>
    <name>G3BEA3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_110516</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEA3"/>
    <dbReference type="STRING" id="590646.G3BEA3"/>
    <dbReference type="GeneID" id="18246198"/>
    <dbReference type="KEGG" id="cten:18246198"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_8_0_1"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="50"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="429" mass="49453" checksum="2C8050801C6A8033" modified="2011-11-16" version="1">MLDPKHEYEKEINVFTSYHDSERSVNQVTNAAEVGLSLLPTQIERHSQRKGGHFNLMVAGTVGTGKSSFINTLFASELVPDKSGFSSTYLDKGEYQLVEQGFPLSLRIIETSGMGQNIDNNGCWIPISNYIDEQFSTYLFKDQQPDRSKKIDTRIHCCLYFLPPSLRSISPLDIETMKALCSRVNLVPIIGKSDCLSVEELARYKSGSKNLFQVHNIRICDFFTDEEATSIIQETMPFSSISSKDILEKDGGNWARGRSYPWGYFAEIEDSSHCDFSCIRKMLMSDFMLEFIDSTEKHYEQYRNQFLTTNLAVKDETLLSADGFNQLKAYSKLKYADYDNTQRADSVFKYRESVLKNKFNVEIENQEKRFRIWKKALVEKQVELNKDIEDMHSQLLYLQETITIHEEGVDSNSIAKHFSWEIDTFDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEF2</accession>
    <name>G3BEF2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116597</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEF2"/>
    <dbReference type="STRING" id="590646.G3BEF2"/>
    <dbReference type="eggNOG" id="KOG3801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120076_2_1_1"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="88" mass="10533" checksum="6DF5143549C1333C" modified="2011-11-16" version="1">MPNQQEVLVLCKALLRKAYKFDNYNFREYSKRKVMDEFRAHRSVSSPSEITKLYNEGINQLAMITRQTHISQMYTFDKLVVEPLKKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEI0</accession>
    <name>G3BEI0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_116627</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690403.1">
        <property type="nucleotide sequence ID" value="XM_006690340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEI0"/>
    <dbReference type="STRING" id="590646.G3BEI0"/>
    <dbReference type="GeneID" id="18248376"/>
    <dbReference type="KEGG" id="cten:18248376"/>
    <dbReference type="eggNOG" id="ENOG502S64Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050724_0_0_1"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833553" description="Vacuolar sorting protein Vps3844 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="3">
        <location>
            <begin position="271"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="368" mass="41163" checksum="58BBEE9A78FC9E4A" modified="2011-11-16" version="1">MKLFLAACVYFTVAIATTSQIAVYHLNDLSKPSLIPYVSSEEALMYLSDKLDLNVFKLSDYNKHETIEFIEQQNEINPPNDRPTLVVSLSGVELSEQPSFKISNPNKFWNQYHQMIKSATKAVPVTEEISVVASDASTVSGLKDHFKYFDVKLQSIWSNFKQNIFSNDINYVNDKFFITEISQLVHLNDHTFGPHDVVLVQLNSLHSMSGKIGQDSQTYQSSENILNSLLKLSQFDILVIDNAVPAPLQLAKRNQQLQKVFRDATLQTNGCFDKEETCQVQTSNCNSHGLCTKVSTGCWSCACSATFNQTLSKTTNWSGFDCSKRDISTTANLLLWSSLALLVMFVYGVKLLVSVGNEPLPPVLDTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEL2</accession>
    <name>G3BEL2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N2227-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116651</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEL2"/>
    <dbReference type="GeneID" id="18248389"/>
    <dbReference type="KEGG" id="cten:18248389"/>
    <dbReference type="eggNOG" id="KOG2798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030612_3_1_1"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF11">
        <property type="entry name" value="AER338CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="440" mass="50108" checksum="F5233675A6C1DF37" modified="2011-11-16" version="1">MNVHDRDLILSTLFGTSILYLTLSALSSNKLFPLLLVVFIAGNMIPRLRSFESLIGKLRSSTNSGINAAIIPTTSKPNSVFRQLPYQKREEIISAIKSLQLYATNNMKSADRRRRLFKMMSWRQQNLCKQAGYLEKLDIMDVLLKKNQLFLNEVVESSINAYEISFSDFDIIKNFVDSSSYRVIESLTHFNRDWNMDQSHDEFELGPVIKFIETQLSQVIPNADKPNTCIVVPGSGLGRIPYELARKGYGQVHSVEFSGLMYLFNQFVYSNKESSLANLEVYPYVHTNSNFESIADQSRSILIPQLQQPTNLSMHLEDFNTFELPDPGQCKNVVIVTAFFIDTAENLMDYLDSINSLVKPFRNSYWINIGPLKYGSAPKVELNMDELAHLRTALGWTDLTTINTLKQPISEGENGLYSYATDKHSLWQGYYGLTGWCSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BER9</accession>
    <name>G3BER9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_96026</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689792.1">
        <property type="nucleotide sequence ID" value="XM_006689729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18250569"/>
    <dbReference type="KEGG" id="cten:18250569"/>
    <dbReference type="eggNOG" id="ENOG502SGH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254170_0_0_1"/>
    <dbReference type="OrthoDB" id="4084534at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1553" mass="179284" checksum="3A88372F85D1ABE9" modified="2011-11-16" version="1">MLRSSFLLTPKRVALAATKLSGYSLSRAYTASNHVAFYATSSNNEEVEYEIDIITLTKTPKNKPSKTSINDLVNLKLINSSNIDKALVEQSINQVNQSLDEDLNKFVLRYSVELNDFLQFIRSSYENKIHNFNQLTSVEILNSLYIFKDFYLKNKIPKITRYNYISYNYMFDNFLKCLKKFPNLPEILNDLLLLNNQGIDLLNLGISKYVEDLEILNRRLDLSDHSLTFDDFIREIQKTINFYEFNLDSFGRSKVFTEPFYESFIQANRLKNLKSILTKVPNIEPVDLGCLIKNKHFLKIVESLNADAASSQSSKSVNLKFLKFIIPDSDSNYLQIISALNQLKSQNGANKIPLVDTMHSSLVAMSCSGSIYPYHKPLNFPLTQFKISNDLVRNFEFSMVFDHKLFLYIDELKALNSMGIDLSSADAVNKIGGLKFKSDLLAMNFKSLATQLSEFFKSVTTENTDCLFKLVENKNWMDWCQENYHSRIPRLLVDYSNLSDYPYKSIKISTELSRLLPALSKFSFENDINLSCLSLDYLLSIFKDSTVGSEVLRKLYLNHGNVYLQNLQGLLEDFNNLQFTLLKFDLPKVKATEGKDFKDFTQFELEKHFGYISTLINDPLILDNLDQLYRENSPLNSIDAKQVLTQLSAFKYELEILKVDELQNNFANITSDELLFKLDRRIKEILSNLNSNPQSRLGPTNVIKFIELQKLLTKLFTVQDDCSELDKFIEYRQIPERFNLHDSSPDLFKIHQFIGKNYKDCSMGEILEAVNNYTESLPESSTFDRQRFFRLSIKMKQLFRLTGGFTDVLDSIIANQVEFEKLESKLLSSKRRKFEAKPLIVKIVKDIPESAKPKKTYVQIPDDLKIHEFAKELNSLKVFEFEGKELGSFTPSEIQTLLDERINQFLDGSVSPDCYINDSNVECYSKLSSKLGHLFAVNGGHTDVLDAIINSELVFESFEKRMARKEKTYRPLPDDFRLQEFVPEIQQVQSELEKQTKAQITNFKFSEVDSSEVLKALSSMIENEKRFNLTKRENFAKLLKNLKVLFNYNGDNTSVLDNILINHEVLTQVASKPKAQVKSDMSAFVDSYKEYLPQFFATGFKNYDLVNFYDLSSEDFSNKVKSFISHIKKDFKYQYPTYKDFTEKLVALYEQDPINLAILFKVNEAEGHPDIYAVKKEVSTFMDKLSKNKDLYSKEDPEPGVQFQKSTEVPYEKFNIHDFKSKSEPKVQEFKRSIEVPVEKLDTNDLYLKDSESNVQQKSIEVPLEESCNHDVKSTPVNGEDVNYNHGTSKFNIKESTMEDSELFVRNQIFHQVENKTGSAGDFEDLLKMTPEEIRSTYHAKAKLDKLNIQNYLENVNEQKKLRDEEEFRQLKAFEWSNNKSRSLDAKTFFDPWSERSQDHLQYLILTMDGEKIITEENPLGKEQFEDLLAVFDRFNEAEMSKFIKNINRLQQKSWKLIGGGAGNYGKMLVFTKSKSKSSMRGIFRKIQTVLAATGATFMVLIGLNYWLDAPQTQTISVPPKEEVAEKVIVSAEPLSQTQDGVESQSQAGWFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEX9</accession>
    <name>G3BEX9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115987</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEX9"/>
    <dbReference type="eggNOG" id="KOG1296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114688_0_0_1"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV59962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20568" checksum="F9EE70F6B0C29FB5" modified="2011-11-16" version="1">MRTTVLSIKANLENCTDVEPVDNEDYPHDYGFTIECKACKFRHPKQIMVNRFDTEHVQLYVNKPTRVVNFSIKCKDCRRVLFIILKRTEQSLTLQDSEHDTFVPILDVHTHGCIIIDFSLEDQFQCKTMKGKVIDGVDLRGNDWSEFDENGNVPMTITDFSYKLTTLDGNAEVTKLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF31</accession>
    <name>G3BF31_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_96066</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF31"/>
    <dbReference type="STRING" id="590646.G3BF31"/>
    <dbReference type="GeneID" id="18250575"/>
    <dbReference type="KEGG" id="cten:18250575"/>
    <dbReference type="eggNOG" id="KOG1531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_4_1_1"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="287" mass="31899" checksum="D095AC4A4EADD429" modified="2011-11-16" version="1">MFRLGVNQIARPNGARNYATLREIEMRLKSIKNIEKITNTMKVVASTRLNKAQRAMQASRVYHESDSEFYKNAELEQPETEGNTLLIVCSSDKGLCGSIHSQVAKYARKRIEELGGKVDVVAVGEKVKAQLLRTHDDKLRLAFNGIGKEAPNFHEVSLIADEIAKLGKFENTEILYNKFVNSVSFEPSNFSVFTSEAIEKAPGLSKYELENEETTEAFAEFSLSNSLLTALAEGYAAEVSARRNAMDNASKNAGDMINRYSILYNRTRQAVITNELVDIITGASSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFH6</accession>
    <name>G3BFH6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_100049</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="G3BFH6"/>
    <dbReference type="STRING" id="590646.G3BFH6"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
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        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="189"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="445"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV60695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="752" mass="84143" checksum="408FE90CA213499F" modified="2011-11-16" version="1">MDEDDGLLLNFAVDSGAPAKKARGSVKVTGGRWKDRRKMQLTMSGRGRNEKKSHTRTSGVNSIEVPNARTKRTTADPREANGSGTAPDHLQAQHEERIKRIKFSEGKGEFGGKNNSYVSSLFTSNTKSSVLEESKKDEEKEDVTYLPSNAPLKDATTFEGLGLNPKLVSHLTETLRFKNPTKVQRSTIPSLLFAKSDLFIKAQTGSGKTLAFLLPIFHKLMQEDKHKITRESGVFAMILAPTRELATQIYSVLETLSRCHHQIVPGIVIGGEKKKSEKARLRKGVNILVGTPGRLADHIENTQVLNLSQLRWLILDEGDRLVELGFEETISKITNQITKTSEIHHTAPKWQGLPTKRVNVLCSATMQENVEKLGSILLDNPEMITVDSKRAIEGTVIFNDDDVEETETEDTSQNMTAPDQLTQNVLIVPPKLRLVTLNAMFKNFTHDRQVDHLRTMVFFTCSDSVNYHFDVFTRGGKPLSKHKEGSEDDAEEFEYSIATAPLISSDTAVFKLHGSMTQQERTSTLQGFVKDSSVYKHSILFCTDVASRGLDLPNISEVVEYDPPFSIEDHLHRIGRSARVGNEGSASIFLLPGIEETYIDAKLSIVHPKGSLKIEGYEKLLKKAYSEPDSAKGRGKWDIHATTWHLNIERWILEDSGVHDKATLAFTSHIRAYATHLSSERNFFNVKELHLGHLAKAFGLRENPKKLGRSFGNNQSKDSGDKSKRTRKLDPRQKMLHMARMAVKASSSEFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFL8</accession>
    <name>G3BFL8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116074</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="94" mass="10201" checksum="6999B27DE0DF082D" modified="2011-11-16" version="1">MVSDTRGSQSHPSAIPTTNGQQQGNPMDVYTFNNRNNSSSSSESLGTSAQLPFNTPPLRTPVTMDGKGYFPTTNQNAPIIKGRGGYQKRSKKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFR7</accession>
    <name>G3BFR7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1751-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116787</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006689868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFR7"/>
    <dbReference type="GeneID" id="18248442"/>
    <dbReference type="KEGG" id="cten:18248442"/>
    <dbReference type="eggNOG" id="KOG2890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043563_1_0_1"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="329" mass="37196" checksum="C716351D37784AAC" modified="2011-11-16" version="1">MPFLSRSHHLPNSTRVLLGCLVTVSSLLFFIKLARFRAASGDIKLHDIRVPYIQLIPRYTIFYPWAVVTSIFAEISVIGFLLSTAVLTVTSRYIEKFWGSKEVIKFVFIVCSVTNFLTVLITIISNIIRGDAMGMDKPLGGGISYYIGFLVALKQLIPEHNIVLFQGLINFRVKHLPFICVSVSLLWSLLFSRSLYPFIPSVESFLITYIYLRFFQLFTVDPLLPVSSNDAGNVIYGDASDVFKLVEFFPDISKPVLSVVFDKIYELSVLLGVIAPFNDDSVELGNIRAQKRSEQINQTQKSVANSVAERRRQVALQVIEDRINKESRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AVY8</accession>
    <name>G3AVY8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_100245</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996509">
        <property type="protein sequence ID" value="EGV66896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AVY8"/>
    <dbReference type="GeneID" id="18245372"/>
    <dbReference type="KEGG" id="cten:18245372"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015387_0_1_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="48315" checksum="66F903E5A5C5B4BD" modified="2011-11-16" version="1" fragment="single">DKHVDDTVRLIRLLRALNNHFPIQIVFYDSLSDDTKAKIVAAARNKMVDLPESFHKVSKHFPSDYLTAQDSGLPKQEVWFVNTYNAIHDNFKDKFKRFANKFLATLFNSFEEFMLIDADTILLQSPSEFFDLKDYISTGAYFFKDRTAPQFRPPGDTKFFQKITPSILDTLMFDIPIITQKTLGLEFFDGMGHFMESGVVLINRHLHFNSILTMLQMNFFRPVTARVHGDKEIFWLGFAASGDEDYHFNKNFAASIGTITSQEERLTSQGNHKKSQELCSPHPGHINENGKLVWFNSGFKFCGKSDLVDFEAEVKKQEHFKFLKDAKSMQEYYEGSLILKSAIIPPFMGKLVTRADNKVEEPAEGWHMEGGYCHSYLWCAYSSIGGLTSDGQDNTQVGQVFEFDQDSIDLSSYFGDIWVGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW55</accession>
    <name>G3AW55_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phospholipid methyltransferase</fullName>
            <shortName evidence="17">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_112186</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573</strain>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="17"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW55"/>
    <dbReference type="STRING" id="590646.G3AW55"/>
    <dbReference type="eggNOG" id="KOG4142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086119_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 17 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 17 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV66769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV66770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="209" mass="23338" checksum="E582690FAF31AF68" modified="2011-11-16" version="1">MSLLNDTKFLVQNIQDYVNVNDQLAYSLACIAFNPIFWNIVARLEYNTHILTKVSGGARNGCYLLALTIFSLGIYRDYVYHAALEAQPTFEPFVNSDIIKALAITSFGFGNVLVITSMYTLGVTGTYLGDYFGILMDERVTGFPFNVNDNPMYNGSTLCFLGTALWYGKPTGIIVSGLVFVMYKIALLFEEPFTAKIYAAKNTQEKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWH9</accession>
    <name>G3AWH9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein S5 domain 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_91712</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWH9"/>
    <dbReference type="STRING" id="590646.G3AWH9"/>
    <dbReference type="GeneID" id="18250104"/>
    <dbReference type="KEGG" id="cten:18250104"/>
    <dbReference type="eggNOG" id="KOG1614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_1"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="188"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="301" mass="34259" checksum="A37D1499727935E7" modified="2011-11-16" version="1">MKSNDISINETKYIIESLKQGTRLDGRKLDEIRKPEVVLGDNGYVELGWGQTKVVIKTSSEIVKPFEDRPNEGLLVINNELSPMASIKFDERSVDEVMINRIIEKSIRKSNALDLEGLCIKTGEKVWLIRVDLSIINFDGNLIDSCCFGSIISLIHFKLPNYSLDTNGNIKVYNLDEKPPISLSVLHIPITLSISFFNPLNDEENLKSNNNYEISVFDATMKEELVRDSYLVVSVNSNKELIQLTKLGGIPIDSVELVNLCQRCYAYAEELTELIKTTVKRKEEEEFKRLNLRLLKSVDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX58</accession>
    <name>G3AX58_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112432</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX58"/>
    <dbReference type="STRING" id="590646.G3AX58"/>
    <dbReference type="eggNOG" id="ENOG502S5NC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442678" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="115"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="266" mass="29584" checksum="9A0CB652B33B8597" modified="2011-11-16" version="1">MRFAIFLLYLVMGALAKNVFDLNKFKDAVNDEKNAKRDAKNVYNLDDVKVGLSVLNSKRDAKNVYNLDDVKVGLSSLSSKRDAKNVVNFATFKSDVEAEQVQKRDQVVMEESTSALLLQSILPQYTSISVFAGYIRDNSEINEKTESLAESLLIICPTDNAISTKLGGLKPWEFPKSLSEGNEDEVVESNLSYFVSNHIVMNFEDLKITERSVKATLLSGKQVEIVQVGEKIGLVSDDGTKINVIMAKQVDNGYIFIIDDTLVKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXC8</accession>
    <name>G3AXC8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_117079</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXC8"/>
    <dbReference type="STRING" id="590646.G3AXC8"/>
    <dbReference type="GeneID" id="18248547"/>
    <dbReference type="KEGG" id="cten:18248547"/>
    <dbReference type="eggNOG" id="KOG1980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009858_1_0_1"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="83"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="762" mass="86830" checksum="4CFC1047762E5D8D" modified="2011-11-16" version="1">MVQGGHSHRATVKKDHKPFKAKHATKGHLKNITKGKVEKSSGSGKQIKSMSKIERKNQIKQLKENKILETKLTRKVFEGFQGAEKVVTIIPLTNDISAAQIASSLVNIVKDPNEIEYEFKLPSVTNIRVQRFRSNLKIIVPDSNDLLSILDAAKVSDFVLFGISATQEVETTYGEQILRAVTAQGIASVFGVVPNLVSAFPKKNLQNDIRQSLSSYFKHFFPTEEKLYALESESDCLTCIRTICQKFPKSVKWRDARGYMVTDNVYAEDGNLVVLEGTVRGVGFNCNNLIHIPGKGDFQIDHIEKVSREMGDYILPDENQESLEELNPEEVQMEDDWDGFEDEGNNLDYGVRMDGKEYFDDGSRDLQRRKFKVPQGTSEYQSKWLLDDVLEGVSDVESVDEDEFPGFEDNHLEDDDEMEADEDDMNGTTENGESEMFVDLSPEEEQRQLAEFRANAKEDQEFPDEIELHPNESAKDVLNKYRGLKSLANCDWDYDEYDDEAPKEWSRLLRISNYKSTKNKVHKEAIKNAQVTIGNKVKIYIKAPADIIQDCTTKPYIVYGLLEHEHKLAVVNFFYENWEDFEESIPSKETIIAQYGPRRQVIKPIFNQASNSPNNVHKLERFHHPGNASIATCIAPVLFYNAPTIFFRQAEDGSLQIIGQGTFLNCDHTRVVAERAILTGHPLKIHKNVVTVRYMFFNPEDINWFKAVPIYTTSGRTGFIRESLGTHGYLKASFEGKLSAQDVVAMNLYKRTWPEFSTQFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXQ2</accession>
    <name>G3AXQ2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LSM1</name>
        <name evidence="8" type="ORF">CANTEDRAFT_96781</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684245.1">
        <property type="nucleotide sequence ID" value="XM_006684182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXQ2"/>
    <dbReference type="STRING" id="590646.G3AXQ2"/>
    <dbReference type="GeneID" id="18250630"/>
    <dbReference type="KEGG" id="cten:18250630"/>
    <dbReference type="eggNOG" id="KOG1782">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_0_1_1"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000045">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="166" mass="18628" checksum="0A7AEE5AD5A42007" modified="2011-11-16" version="1">MSAPNSRSISDGSSNAEDLYLEAYAFTTAAALVGSVDRKIFLLLRDGRNLFGVLRTFDQFANLVLQDTTERIYLDAEGSKSLEKPARFGETYRGVFMVRGENVVMMGAVDIDHEDEHLEVLQNIPFEAAEAELKAIQRERVQAEKQKTKSLLSRGLINDFTKSDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXU1</accession>
    <name>G3AXU1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PI31 proteasome regulator C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_133104</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXU1"/>
    <dbReference type="STRING" id="590646.G3AXU1"/>
    <dbReference type="eggNOG" id="ENOG502SE4N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918356_0_0_1"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="3">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="320" mass="34109" checksum="8D1ED7B7533B234D" modified="2011-11-16" version="1">MINNFYELTCALTNDYIGRYNRSTFVKKIVQAGDKLTQYFVYSDQSQQHTILIANVVQLTPQKSVVTLCGHKQDEGDKVDSVVVDWSILNPKNSIVLPLDEINLSSEIIALFNSQLDKEVNREYMEALFKRSLRSHEKASISVPASESASESASAVASASVPASAPSTFLSDPPASKNASIPDKPGFDDEYEMQSHRAVLGLPPPGGPPSGGVPSVGDDDLYPGGIKDPSTRGYLDPLRDTSRGSGGMYPSANHPLFNRDRMGGPGNAPFGARYDDPLVGDPDDMDLMGAGLPGFRKPSGGSGGGGFPGQFGNHNPFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY04</accession>
    <name>G3AY04_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_101734</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684312.1">
        <property type="nucleotide sequence ID" value="XM_006684249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY04"/>
    <dbReference type="STRING" id="590646.G3AY04"/>
    <dbReference type="GeneID" id="18245496"/>
    <dbReference type="KEGG" id="cten:18245496"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_2_1"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF29">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="63730" checksum="1B49B4E474FDE819" modified="2011-11-16" version="1">MTSSHSIEVLETDLNSGRISLQDSKEDPKSTVQVSILSDTSEETVTETNPFADPKVAEHYRGIYEKSNYECKDVFDPDYKWTPEEEKKLVRKLDYRVALTSCILFVALQTDRGNLAQAVADNLLVDLGLTRSDYNLGNTLFLVSFLLAEIPMSLASKKLGPDVFIPWQIIGFSVIAACQFWMTNKAGFLACRVLLGWIEGSLVADLVLWLSYFYKSKELTIRLSWFWTTLSLVTIFTSLLAFGILRMRGVHGYAGWRWLFLIEGIFTFLIGIAGFYLMVPSAVETKNRFHPKGWFTDHEIKIVVNRVLRDDPSKGDMNNRQAVDWKGLWMSLTDYDVWPIYLIGLFAYASLNTTGPYLTLTLKQVGFSTFNVNVLTIPANVIHIIVLLIITWASEKVNSRSLFALILPLWNLPILAAMTWWKGTNINVWGTWTLYTILAGQPYIHAICVSWASRNANSIRTRSIAAAIYNMFVQLGSIYSNNIYKADDYPLYKNGNRTLFIITLVLVPLFLLVRQYYIARNNYKSKKWNAMTPDEQHEYIQKNAHLGNKRLDFQFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYF3</accession>
    <name>G3AYF3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_118624</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYF3"/>
    <dbReference type="STRING" id="590646.G3AYF3"/>
    <dbReference type="eggNOG" id="KOG2807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028556_1_1_1"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="102"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV65837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="488" mass="54291" checksum="57FCC0C2E5E11BFD" modified="2011-11-16" version="1">MESDDEYKGSSPSSRGSFSDSDGEGVRRGIKTANPASRNANDKKGANGAYAWEDEYQRTWDIVKDDDSGQTLESLIQNMIESRKKKIMKNPTAPYQRGIIRTLVVVIDGSSIMLEKDLRPNRFSMMLSLLQEFVVEFFDQNPISQLGIVLMRNGISDVVSDVNGSPQFHLDKIRQLRGKQHNRFEPKGDPSLQNALELSRSLLRYNFGNNINDTKNSKEILIIFGALFTSDPGDIHKTISSLVKDNIKVKVIGLSAKVAICQEIVNKTNHTSNNFNNPNYGVIMNESHFKELLMDCVVPLPITVEQQKEIEASKSVPLLKMGFPTKVQPTLSSSSGGHSLDFIQICACHSGSRTENGSDAAAIQQSSSVIGYRCPQCSSKVCSLPTVCPICGLMLILSTHLARSYHHLVPLVDYEEVPVKGSYPSSFCYGCLLQFPEGIENIHKDSKEKLETMSSSRYRCKKCKNDFCIDCDVFVHETLHNCPGCENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYS9</accession>
    <name>G3AYS9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112798</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYS9"/>
    <dbReference type="HOGENOM" id="CLU_1943082_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="130" mass="14830" checksum="DFDEF1D6879BADE8" modified="2011-11-16" version="1" fragment="single">MDISINPKPMIQSAPLISKFKVNPSKKFQTTPISNVKFPTYLTPHKSSPYNSKKRVRVIPQHPYTTTSPFFPRSRYYYQQYTPQPSANTYTRVYPFLPPLQSQHFSSGPIQAQAQAQVQAQAQVQVQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ52</accession>
    <name>G3AZ52_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_112876</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ52"/>
    <dbReference type="STRING" id="590646.G3AZ52"/>
    <dbReference type="GeneID" id="18246715"/>
    <dbReference type="KEGG" id="cten:18246715"/>
    <dbReference type="eggNOG" id="KOG3983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036311_1_1_1"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="346" mass="38982" checksum="AC4ED90FACEEFC12" modified="2011-11-16" version="1">MSSEGLQRRRGGKSNVASTTSAPASKPRSSNSFDNEEAEAIQNDHKIGIDDRDIQDRRQLKVPLLTLMEEVLLIGLKDKEGYLSFWNDNISYALRGCILLELAFRKKITLVNDPARRRFELADRLVEVIDTEPTGEVLLDEALQIMKNDDSHLSVTNWIDLLSGETWNLMKINYQLKQVRERLAKGLVDKGILRTERKNFFLFDMATHPVADKLSKEFIKTRILCLLGSRNIDIDQICNDQFPTDTSFKLLRSIALVSGSYAANVLENVLLSLNYSKRDQAFARADELLNDFSDFPFNTSHASPLGIGLNLGQEVTTEIEKDASSELQLELIAAVLSVFAKMDSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ62</accession>
    <name>G3AZ62_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112879</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ62"/>
    <dbReference type="HOGENOM" id="CLU_2542350_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="83" mass="9137" checksum="9FF42F3F3AD10BED" modified="2011-11-16" version="1">MRVRPFQSSCTSTPHLFPYLQTTSKSNSGGQIHGSARQLVTCSDVSKVGQGKSGQISGKIFAIKPRFTFIKKIGTRPITYIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZA0</accession>
    <name>G3AZA0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_101201</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684620.1">
        <property type="nucleotide sequence ID" value="XM_006684557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZA0"/>
    <dbReference type="STRING" id="590646.G3AZA0"/>
    <dbReference type="GeneID" id="18245446"/>
    <dbReference type="KEGG" id="cten:18245446"/>
    <dbReference type="eggNOG" id="ENOG502SBHH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089394_1_0_1"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="182" mass="20729" checksum="1A05656CFA94B495" modified="2011-11-16" version="1">MDPSNHKDILTEQLLHLVDQYESLANTSFRTNFIDGFLNLSRANFNGGGLRTYGVKDFDLRSYLACKNIKSGPNLELEDYLQRQESKKHDKEPEYTKKDQTTKQNQNTAVSSSVHRSKNESISHTEEFGNSLYKDPINQFGALVPYQLREAQASFNLALINSVELVNLQNKISSIISQIEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZC3</accession>
    <name>G3AZC3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112921</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684872.1">
        <property type="nucleotide sequence ID" value="XM_006684809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZC3"/>
    <dbReference type="GeneID" id="18246736"/>
    <dbReference type="KEGG" id="cten:18246736"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="546" mass="62268" checksum="147BC7E1D2D25C8B" modified="2011-11-16" version="1">MTTTYTLSRESHKDPNTFRIKYKDAKLVLDDREQSKWYIDKSIPVKETSSKVAIIGGGFSGIGAAMTTINKLGESDLVLFEKHESLGGTWFANTYPGCASDIPALWYSYTSELVSNWSELRPPQYEMLEYIRRVVDRYQLNSKARLKSQIQQATFNEKTNHWEIEGFNLATGERFKHTAQIICNCSGGLVVPNKFAPKGMETFKGDYMHSGIWDWSVDFKGKKVVVIGNGCSAAQVVPELLKFEPESVVQLVRSQHYILPPHPRFLLYLYNLLSRWGFGLLLLRWIVMIVAESRYPMYKDTGLVGRFVRWWNTRNSVRYMRKTVPKKFHDVLIPKYKIGCKRLIFDYVYCPTLHDPRIDVKAEQVVEVKEHSVILTDGSEIQADIIVACTGYDLNKGAAPYKLIGRNGNDVSKYWKENGPSAYETFLAKDLPNLFLIAGPNSASGHSSVVQAIEISCGYYAKVAKKILDGTYASICVKDEKYLEWFETTQKLLKQSVFGTAYGGCVSWYSDAKVNFAAYPYSQITYFRRGRNVKWDDLDLVKTKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZK4</accession>
    <name>G3AZK4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112479</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684178.1">
        <property type="nucleotide sequence ID" value="XM_006684115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZK4"/>
    <dbReference type="STRING" id="590646.G3AZK4"/>
    <dbReference type="GeneID" id="18246536"/>
    <dbReference type="KEGG" id="cten:18246536"/>
    <dbReference type="eggNOG" id="ENOG502QTQR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072858_0_0_1"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="44"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="264" mass="30230" checksum="253C42391C77921B" modified="2011-11-16" version="1">MGEREDIIKEYVSKSFKRHPKLHNPGAFSMLKHWVEQVYGRKTVLFCVDVEAWERDITKVTEIGVSIFDPRKQEDAIVPTLMNFHIRPKEHNHMKNGRYVPDNSMRFAGDVTHIMTMEDSIRFVQYLIDKYFNDSSISCSLVGHDLHGDIKWLRTLGINFPENAARLDTQVIIGFSSERQMSLVNSLVALGIPYSNLHNAGNDAYYTLLLALKVSDPITRQLFGLDDSVLIQPPKTKRKATCEQKIISDLSEIIDAFESNIYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZP6</accession>
    <name>G3AZP6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_91949</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZP6"/>
    <dbReference type="GeneID" id="18250135"/>
    <dbReference type="KEGG" id="cten:18250135"/>
    <dbReference type="HOGENOM" id="CLU_1524947_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="176" mass="21019" checksum="1F50596B2B6165E8" modified="2011-11-16" version="1">MSVKEPLLDQQEWEMQTVDPYEDNFAFARLHDLAMNRYRHLISRPQLFDLLQQAYENSLENISEAEQQETLRILREFDPIRWDLLVAYVDANLNYQMFLKRLIMTSTTKGVEISKDRQKIMSWYSFTGKVSPEYSQYQSFAEAHIPKEGRPCLILTFCVLSFFFWLAGLFIYLQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZT1</accession>
    <name>G3AZT1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_102648</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZT1"/>
    <dbReference type="STRING" id="590646.G3AZT1"/>
    <dbReference type="eggNOG" id="ENOG502RWDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_0_1_1"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF166">
        <property type="entry name" value="ADR278WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="522" mass="56559" checksum="267B9FB8F1AABAF1" modified="2011-11-16" version="1">MNSGSVGTSHQHHNSHVFRRCLALFMSIFVGLASGTPYLYGIYSPQLVKRVQLTASDSATISLAINIGTGVGGFLGGILIDHKGPQFCIFLGSIFIFLGYMGLYQVYRHAYSSLFVICFCAMVMGFGSIASYFATLKASQTNFPAHRGSAGVFPVSSYGLAASLFSLVTAKFFESDTGGLLRFLSLCCGTTVFIGSWFVKIFVDDHPVDEEAETQPLLSSSSEANTEDAETAADMKLSYSDNASIAGSISFWGIGDRTPRSSSSSLSPDLVPTVNGLREENASATPKRPAFSNRNNSFASAWIIVWDLLTNRQFLAHFSLVALFTGSAQTYIFSIGFIVAAQVTYSEYSDLNAPQVQALQVAILSIASFSGRLTSGILSDFLYKKLHIQRLWIIIVNTAILAVGLFITSVNNGNIHLISLTSALIGGSFGLTFGTYPAIIADFFGTRTFSTTWGLICMGPLLVLYILNKFFGIIYDANTDPDTGICYKGNGCYKGAIEACFSLCFIIVVINILLIYIHRKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZU5</accession>
    <name>G3AZU5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_102983</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684927.1">
        <property type="nucleotide sequence ID" value="XM_006684864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZU5"/>
    <dbReference type="GeneID" id="18245598"/>
    <dbReference type="KEGG" id="cten:18245598"/>
    <dbReference type="eggNOG" id="ENOG502S12S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121536_0_0_1"/>
    <dbReference type="OrthoDB" id="4082971at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="159" mass="18272" checksum="DCFF5C53EC872491" modified="2011-11-16" version="1">MDVTAEQIGAEAAPADKQPVNAHVGGGTVLPAKKSKKKVRKPQSEEEYQFQKHLFTQSGPTINTDTWLYDEQALEDLDKDKKTDRMRMLNACEKAYYDRNYPKCLELIAQAETLFGVHQHPVTTREDLDTKVKKSNRVERHITDLVHIKEKCLHKLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZU7</accession>
    <name>G3AZU7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_97178</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZU7"/>
    <dbReference type="STRING" id="590646.G3AZU7"/>
    <dbReference type="GeneID" id="18250664"/>
    <dbReference type="KEGG" id="cten:18250664"/>
    <dbReference type="eggNOG" id="KOG0942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_2_3_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="620"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="970" mass="112798" checksum="37DA8418147C6940" modified="2011-11-16" version="1">MVNFTGQSRKRVVNLGDNRMTHMGGNRTYLEKTKLQRQQREEQRLREKAAVTLKQYVLRYLSHRKAAEAYYEKWLTTSIGSQSQFDDWIIGLNYFCVWKFPFDSNESIITPLLETVYKRVDEWKLCRVTSQSSVEGLLQLIEVLRTSHSQQLVHRTCQCIEHILKKSPTDARYPGFIDTLTSVVDVDDELVTSLIFRVNMKDSYFALLKFLARLRTLSSSYLDLLRKALSDHESTSAIGDLSKMERIDLLVVFLSAHTSPTYVLEDFVAIDHILSQVSFSVYCDESAMDYDKDGEDVERKDMLRIGVEAHQLLRTLYSGDFIKTMMDFMSKKDHDVYVINIVSSLAFLIPDQKPRLLMFMTINHYRYSWFYKRLTSTFLYKQLVSVAESKGKEYWTYTDFKTLYEQEPTPEFFWRLLFTFTEMFSYWLIISNDFESFSDDGITTENAASFVVFLKRLCLTMIFNSNQTHSTQICHDFYKVKDASIVLLNQLYLKNLRLKFMDESVWSLKKYEFRLESVLHLISDDDDEVSSDSDNNDIQVPGKDRQRSEISAKLEILKKLPFFLNFKERVQIFQRLIDQDKPKNGADMPEFFFGSPTRSTQVNARREHLLEDGFKYLGQSGPQLKHGIQVTFFNEYGQEAGVDGGGITKEFLSGVVLEGFDPNGQRRLFKETSEHQLYPNDEIFTKYYNKIDFEQQLEQLQYLRFLGNIVGKCLYDQVLIDVSFAPFFLNKWCNAKNMMKNSINDLNYLDPELFKNLVKFTKMSGPDIEDLDLNFTVNTRADGKQFKFDLVKNGEAIKVTAANRSNYIHQMANFLLNTSLHIQSKHFLQGVFAVVNSNWLKMFDFNELQMLISGSKAKLDIANWKQNVEYGGYLESESTIQYFWQVVEEMTSEEQSKLVKFVTSVSRAPLLGFQSLNPKFGIRNSGRSTDRLPTAATCVNLLKLPDYQDKEVLRQKLIYAINVDAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B062</accession>
    <name>G3B062_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber evidence="14">3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_119566</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="14"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B062"/>
    <dbReference type="STRING" id="590646.G3B062"/>
    <dbReference type="MEROPS" id="S10.007"/>
    <dbReference type="GeneID" id="18248710"/>
    <dbReference type="KEGG" id="cten:18248710"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_11_2_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442671" description="Pheromone-processing carboxypeptidase KEX1" evidence="20">
        <location>
            <begin position="20"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV65326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="669" mass="75145" checksum="B50EF35C36E4C2CC" modified="2011-11-16" version="1">MLFIHILLAMFVQAVFVESLHFKRDSDRSQFLVSKLPGLQENFKDSEIPLMFAGQLELYKENDTHLFFWKYSDNNIEPEYKKRTIFWLNGGPGCSSMDGALMEVGPFRIDSNLKVTKNPGSWHQAGDVVFVDQPAGTGFSYSKEFDHDLDQVSWQFLRFMEVYFEMFPEDADNEIYFAGESYAGQYIPYIADGILKRNKNLKEGQNPYNLKGLLIGNGWIAPDVQSLSYLPYAVAAGIINTNHPAWTKILKQHEKCQNAANNMNGDSLSDFAIVDDICEGILTTLLYETKDNSAAANQQCFNMYDYTLKDSYPSCGMNWPPDLVNVNPFLNSLDNQASLNLILKKKWHECSGRVGSRFTAKKSYPAVKLLPGILEQIPVVLFNGNRDIICNYIGTENFIKQMEWNGATGFQEDYAYDWVYDGQTSGYIKTERNLTFINIFDASHMVPFDKPELSRSLIDVLLKNFDIETVDIPGDTEKKAIVTYPLGVRKLHQEVPQPSSTTAAPTSTNTQVTGSFTQFASSGAAASSPAEPSSSSVPAEDKASGSSRITRIIQLVVLVIIIWGVYMLYSTYKSRPSSIIRTGPSGRKKNVQWADQLRSFQNDEEVPPSGLLNKALGVFRRGDTRGNYTPTDTDDYLEDIEMGENLVPGNVDHFIVDSEDEEEVRKSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0H5</accession>
    <name>G3B0H5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_113143</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0H5"/>
    <dbReference type="STRING" id="590646.G3B0H5"/>
    <dbReference type="GeneID" id="18246834"/>
    <dbReference type="KEGG" id="cten:18246834"/>
    <dbReference type="eggNOG" id="KOG0358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="530" mass="57761" checksum="F82706066DBB3227" modified="2011-11-16" version="1">MSKVASNPSNARFKDKEKPQEVRRSNILAAKAVADAIRTSLGPKGMDKMIKTKTGEVIISNDGATILKHMAILHPAARMLVDVSAAQDVEAGDGTTSVAILTGSLLNAAEKLLNKGIHPTLIGESFQRAAQRSCEILLDMSHKIDLNDRDSLIKAASTSLSSKIVSQHSSLLAPLAVDSVLQITDESKTNVDLNDIRLVKKLGGTIDETELVNGIVMTQNVIKNAGGPIRVEKARIGLIQFQLSPPKPDMENNIVVNDYRQMDKILKEERAYLLNICKKIKKAKCNVILIQKSILRDAVNDLALHFLSKLNIMVIKDIERDEIEFMSKSIGCKPIADVDSFTEDKLGTADLIEEVESSGSKIVKITGISSKSLKPTVSIIVRGANPLILDETERSIHDALCVIRCLVKERGLIAGGGAPEIEVSRILMNESNKLSGVEQFVYKEFSEALEVIPVTLAENAGLNPIEVITDLKNKHENNERFAGISVRRSGTTNTFNDHILQPVLVNTSAVSLAAECVKSILRIDDIAFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0J2</accession>
    <name>G3B0J2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113165</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0J2"/>
    <dbReference type="STRING" id="590646.G3B0J2"/>
    <dbReference type="GeneID" id="18246837"/>
    <dbReference type="KEGG" id="cten:18246837"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148322_2_1_1"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="91" mass="10181" checksum="E5B6E48F92F8EC5B" modified="2011-11-16" version="1">MSEQSPKEEKGDTHINLKVSDGSAEIFFKIKRSTPMRRLMEAFCKRQGKAMDTLRFLVDGTRVGPDNTPDDLDLEDGDLIEAHREQVGGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0K9</accession>
    <name>G3B0K9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_133724</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685104.1">
        <property type="nucleotide sequence ID" value="XM_006685041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0K9"/>
    <dbReference type="GeneID" id="18249738"/>
    <dbReference type="KEGG" id="cten:18249738"/>
    <dbReference type="eggNOG" id="ENOG502R8TB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027971_0_0_1"/>
    <dbReference type="OrthoDB" id="4024240at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="545" mass="62863" checksum="1080526EEE0A314E" modified="2011-11-16" version="1">MYQFNSPIGYSKKPLVYDGRKKEGVGSGDGDAVVWNPAKNVSLDKLPVEILSMIIHYLDQFDSLKLMMTNRIMYALVKPKLYENIIIDSNYSEFNKEFRSYKFQHQHQMTNTTIKLTATFIKSSYNFKRFLSAYDGTAVRRLQCISFPDSVTVLDGDVNDLIVRLFEKLRGLHELVWVPANFKMDFLRHLDLNSNTVISLVVNIRFNRQNLQVLSRFRHLVNFQLGPYTSTDNLRQLVQFVDMSKLRILKLWKSDTQSNICDPSAARLLDYPHGHELEDVNILSTKQFKCLTKLCLKEMFVCEGDFASFASSVSTSGLTKLEFKRITEYKTGHADSFLLRLSRELQSITELMLDYRESHKDNIPEFLRNINHLHKLDLVVRNNDTKTFDAKQYSRSLQVHADTLAHLSLEIYHEKSLGFQPVAVDLQKVDLSHATKLESLRINSTDEIDSVRLVAQLPRLRYLNLFGMKAGGSPNLGLGMIHPTVFDEWFKVQHVALIYLENNGSLEYVKINSCLFECRDGEVVPREGIDNWFNEVVRVAAIDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0M0</accession>
    <name>G3B0M0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_102958</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0M0"/>
    <dbReference type="STRING" id="590646.G3B0M0"/>
    <dbReference type="GeneID" id="18245597"/>
    <dbReference type="KEGG" id="cten:18245597"/>
    <dbReference type="eggNOG" id="KOG2708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_1"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="48"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="375" mass="41676" checksum="55C91BA2D7D49B97" modified="2011-11-16" version="1">MTVDLDKRLRPGRDYYLALGLEGSANKLGVGIIRHGVGEPGPHNSAQVLSNVRDTYITPPGEGFLPRDTARHHRHWVVRIIKRALADAGVCGRDLDCICFTQGPGMGAPLQSVVIAARTLAQLWNLPLVGVNHCVGHIEMGREITGAQNPVVLYVSGGNTQIIAYSRQRYRIFGETLDIAIGNCLDRFARVLKISNDPAPGYNIEQMAKKGRHLVELPYTVKGMDISMSGILQYVDVLAKDMFSSTPKKNKNLVDQESGELITPEDLCFSLQESLYSMLVEITERAMAHVQSNQVLIVGGVGSNERLQEMMELMVNDRKNGSIHATDERFCIDNGIMIAHAGLLSYRMGQTKELKDTVCTQRFRTDEVWVNWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0T5</accession>
    <name>G3B0T5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113569</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0T5"/>
    <dbReference type="STRING" id="590646.G3B0T5"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="283" mass="32374" checksum="24DB1FDE78D832AF" modified="2011-11-16" version="1">MDIPALSRWDTHIKTLGHGTSGRVDLYQCRGSTMVYAIKKYDPKEKHEDFSDYRTRVSNEHLILSRLNHHNVIRSYKLECSWLRSSVQLYLQYGGNATLKGLIAKKCPPSEMFCFVKQLQQGIRYIHSEGVCHRDLKFANIMITPQGILKIIDFADARLGPRCYGIIGTSSFCAPEVFSSLDYNGYKIDVWAFGIIVYYCIFHRFPWNVAKSECVEFVAFINSCDLNLSRLPAHIQTVLTQCLTVDPTQRPGIDSVDTSSWIAGIDCCTPTNSCKYDHCRWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0Z0</accession>
    <name>G3B0Z0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_134147</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B0Z0"/>
    <dbReference type="GeneID" id="18249774"/>
    <dbReference type="KEGG" id="cten:18249774"/>
    <dbReference type="eggNOG" id="KOG0915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000880_1_1_1"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1817" mass="203975" checksum="C5BB9DC7E5C0317F" modified="2011-11-16" version="1">MAEKELDLINKVDLRIALASTDEQLESSLKLYLAPLLLKLSSPHAQVRQAIFKIIQNTMTRLTAARTIRLPAVALLAQVKNPKVADGLDASTVRLYSLLFISKAIDRMSPDEKRELVPDVLHDISAFAPGIGARLFSIFCKLISGWKAPEHDSMEYQGLLKDLDFGAHTADEAFVCAKVARFLMLQPNSTPNPIPSPGLNIADVSFFSKDAGITYKTPQEIFLVKRDLMEFLKVGFSSSNLRLPLLVASSDSSSAINDSAEILYRKLNVDLEDEVFVGQLIDLFTGNEQSGTPPVNPVLQEKILSQLTRSVTATKNGNIAKVTNLGLSTSYSKLKQVTIQFIKWISVHSEDSESDASQSMLLFNKNMAQRLKESILNDGWPQALSVPGKSYTATMNQRSSQYEALCNILKVSPGLFLDEFTYLEFLFDSLEGESVDLRSTIQEGLSSLKVFLPKLSAEGKNQLKELGTKYLSSDSPKNDNIHSCRFMILKFINCCFPFNDCEARYLNVLGTAKTNRPETIEEATRGLHPHWFNITQSSNTNEFKSTLELLGQGNVVVFPNFEVLVQLIDERIKDASSSSIIFKAMGQAIEFVIQTLVMESIKGKSTVIVADEDWSVRLDKAIEVDTKVRQCLKHEIERLSASGGNSFTTLLNIIFSAFEGQYSDFSYVDKQITFESTFWKLLSLSSSTIVAGLSHLVEPFLKVLADRTLADLSLSQVARSASIIASHPVHSSDTVRALLMRLITADLPPHKSRANILVTGHLFSRLAFRQRLDAIDEELFKVFGAKLLVCLEDFSSYYQSLECIGEMAKYGLLGPELSYLDSDFLTKVVDIITPKVKKSDERTVLALSYISLAFKKNGASDSLTDFEQLIYDTHISKQTEYLFTSGEALSILAAGWDSSVLERSIDIQGESVTYIPRSTERLPVLLNTILKSCANTKPSLRKAGCIWLLSVVDFCSSSPVIKEHAAKIHLAFMKFLADRDELVQESASRGLSIVYDLGDVELKDSLVKGLLKSFTDKNSTSKLVSGTVDEDTELFDKDLLKTNDGSVSTYRDVLNLASDVGDPSLVYKFMSLAKSSTLWTSRKGMAFGLGSIMSKTSLDDMMAKNKSLATRLIPKLYRYKYDPSTSVSTSMNQIWNVLVTDSSKTIKAHFSDILDELLKGMGNKEWRVRQASTTAMNDLLNVVEFSVYEPRLEDIWNMSFRVLDDIKESVRKEASKVTRLLANILTNSRQQGGGLDKLIPFLLGNKGLLSEAEDIRSFALDTIFKLIKSNNKNIKQYIPILLENFIGLMSTLEPEIINYLVLNADKYNLKNNDIDARRLQSLGQSPMMDAIEKLIDQLDYEIMEESVKVIINSVKRSVGLPSKVCGSKVLVSLVNKKYEFTKPYGNRLIKAAMGQITNKNDTISSSYAISVGYLSRLSSVDVLVQYGQKLKGLYFESGDERNRLVAAIASESFSKYSNEKFESVAAEFLPLTFIGMNDIDKEVAKVFEKQWIENTSGSNVLKLYLAEVIDLMSSYIKSQNYQIRQNLAKSVVKLTNDINDFNGLSNNLIMKIFDSLIESCKGKSWQGKEQILEALVNYSIKLDSVLQQNDDLLQTISNVVLTEGKRKNKDYQRHALKTMGVFLHKFPNEELTEVYLEFMEQIINDEYEEDDSDEEDNMDVDNRSKKRINNSMNNKLEEEKIVYISNLFEAFSRASPSKEMFSLMSKSILKLLNDDNKFEITWRSKVCGNECFSRVITELGETEFEVESLFQIWKKLSEVCSNFNNIENVKVKFIRNSKQFIKYLKNLHYLDKVRAITSALETFNSDSTIIKAELSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B148</accession>
    <name>G3B148_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_103417</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B148"/>
    <dbReference type="STRING" id="590646.G3B148"/>
    <dbReference type="GeneID" id="18245623"/>
    <dbReference type="KEGG" id="cten:18245623"/>
    <dbReference type="eggNOG" id="KOG2858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025524_0_0_1"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="336" mass="37511" checksum="59EB8439DD864D1E" modified="2011-11-16" version="1">MSDTSALCSICLESSAKYTCPACTARTCSMECIKRHKKQTECTGKVDQSKFIPKKELAASALHINRDYNFLLQMGREISVGKTDVKVNARNVFKRGNNSNYNRNKRPKLEASDAHLTDHRITAVKKHFPENTPYLTRRENTMCVILPDGMSRSTSNKSGYDKKSQTFTWTVQWLFIDAKGVTQKDFLSYRISETATLRDAVPLNVLQSVQENIQKDQLKFYLKNVFAQPKSHHNLYISLDGDAVLANTLKDTVVLEYPTIYVSTEELTVNVVGVEKAYLEDSGSDTESESDSDHSDSDTDSDFSSSSNDSSDQSGSDDEAPEELPINASKPSEPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1M7</accession>
    <name>G3B1M7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113252</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685799.1">
        <property type="nucleotide sequence ID" value="XM_006685736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1M7"/>
    <dbReference type="STRING" id="590646.G3B1M7"/>
    <dbReference type="GeneID" id="90982255"/>
    <dbReference type="KEGG" id="cten:90982255"/>
    <dbReference type="eggNOG" id="ENOG502QSJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054069_0_0_1"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="58"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="302" mass="34226" checksum="6EB6EA48841F9348" modified="2011-11-16" version="1">MTTDAQTANSSQKVDRTTYGLPKPVPAYYPHPGSPLYANKALYTKIANSKKTLVEKHICKPRTGIAFKVPAKSVFRLTTPEGPQVCDLNIWNQHNPRERFWAARTRQLHSAHVSTFDRLWSNLPYLRPLVTITGDTLNARHDEWGGRAHDTLGTRCDPYVDKLISGEDNDFHCHSNLTRAVMPYGLTEFDVHDVLNVFQITGLTEQDQYFMEACPSTKDDYFEVYAEQDLLVAISACPGGDLSQWGWGEDKDDLDGSKMVDCCRPLGVEIYSIDDEEEVLREWQAPEVVNYKGNHGFKEPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Y2</accession>
    <name>G3B1Y2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribitol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_103598</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685366.1">
        <property type="nucleotide sequence ID" value="XM_006685303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Y2"/>
    <dbReference type="STRING" id="590646.G3B1Y2"/>
    <dbReference type="GeneID" id="18245642"/>
    <dbReference type="KEGG" id="cten:18245642"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_10_1_1"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="331"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="558"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="629"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="754" mass="82152" checksum="B15FAB532DAF4BEF" modified="2011-11-16" version="1">MPPTFSKSHTSLGSRKSSVFNFIQQPPQPDVYYVGVDVGTGSARACIIDTNGIILGLSERPITRHELKPNFITQNSTEIWNAICFCVKNCLRDSGVDPSDVFGIGFDATCSLVVIDEKTDTPIGVGPDFTDHKENIILWMDHRAEEETVSINSSNDKCLKYVGGQMSIEMELPKMKWLKHNLPGGIEKCKFYDLADYLTHKATGSEARSYCSTVCKQGLVPPGVDGSTDGWSKEFLLSLDLGELVEDDFRRLGGIPHKNGTFLSAGDVVGKLTIEASQELGLTTECIVGSGVIDAYAGWIGTVAAKVDHPQVSHLLEKSGDGTIATSCGRLAAVAGTSTCHIAMTKNPCFVQGVWGPYKDVMAKDYWCAEGGQSCTGALLAHVLSIHPASNELNHLAETSNLSKFDYLNLILENLVVENNTRSVVSLAKHMFFYGDFHGNRSPIADPRMRASIIGQSMDSSVNALAIQYFGACEFIAQQTRQIVEEMEKAGHEIDCIFMSGGQCRNGLLMRLLADCTGLPIIIPRYIDAAVVFGSALLGAVAAEDAVNEHLNSKGKITRRSSILESQRSQTSLNKVSSGGAHSPYTAPTATASSANMVALAYASSQSGSHHQFPSMTPMAEENVDYFNQPTQSAPKTFSDEDEDDSEDEQTLSFGSKQKVQQGLSQKLNALNLKPLSKIDSKTKDNSPGSKLWKVMDKLTGPGKVIMPSDENHPDRKLLNAKYKVFLDQCFKQQEYRKMVDLVEEENSKGLKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B211</accession>
    <name>G3B211_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113346</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B211"/>
    <dbReference type="GeneID" id="18246913"/>
    <dbReference type="KEGG" id="cten:18246913"/>
    <dbReference type="eggNOG" id="ENOG502S195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037539_0_0_1"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="283" mass="29617" checksum="5F1BC3F54E132DFF" modified="2011-11-16" version="1">MVLQSVTSSPARPSSLKPSPPLNNKGSAHHANKTGSATGTHQQTTPTLPKKQLNVNTATNPLLTTPTQPSQKSNGNHDDEGADLLMYLATSPSPAKSYFPNAPKLGAKQPAKQPPSQPQSQSQAPVASQSGDPLGSSAPNSSGGAFSIHKHTSSNSSANSFIAPPPPLTPKRHINTTMNSKTPQNRLTPSVNLFNNMVNNGSSGLPSSGLALTPAGFNMNDYVNFFSPSPGGAHLSKNFLKTPDFNNLLAANANSSQAQSKVVDGKMINFDKVGLFKNTESRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B220</accession>
    <name>G3B220_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_97459</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B220"/>
    <dbReference type="STRING" id="590646.G3B220"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_4_1_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="244"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="506" mass="56064" checksum="FA88B69EE9883EB9" modified="2011-11-16" version="1">MIHTAQSSGPLTNAISDLELKSELEVPYSPISDNNDQELQISEDESNASSYSDGLLEDLNEALTENSVMSMLPSFNINPTGSEHGKFLVIDLGGSTLRIAVVDIKAPAAGENDEHRADRVNIVNENKWIVSNKDKLIDQNFFRFMSSKIVETIKDQSTISVSDDVINVGITWSFPLTQVSHNSGRIVHVGKGWKIGDDIYDKDLKAVLETTMQQEYGLTIDVRVVINDSIAVYAAGKFLTSHLKIAMVLGTGFNMSCSLKTGQFHSAKTLNEDAVLVNSETSLFGSNLFRLTNEFDHSIDSRFSRTERPFKAHMTFDGATDSIFQPSEFIASGRYLPELTRLAIVKLLNNNEMFRDLTIPPSSKLFTAYDGFSSELMCFVSEQTDISMIKAKFVEEFNIDISNNDTMKVKQLVDSVIQRGSYTIAIVVIAFIKLLVMHNRENIVGEEVIVGYVGSIMVYFNNYRNSIIKYINESPYIKGLGATVDLMSIDDSSIVGAAVGAAYFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B266</accession>
    <name>G3B266_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_120327</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B266"/>
    <dbReference type="STRING" id="590646.G3B266"/>
    <dbReference type="GeneID" id="18248768"/>
    <dbReference type="KEGG" id="cten:18248768"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_4_0_1"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="727" mass="82517" checksum="5D904859E1E467C3" modified="2011-11-16" version="1">MSLEKKIRKFLQGPRKGEAFELKNGLVSQYKHERKDAIQRVIQAMTLGKDVSSLFPDVLKNIATYDLEQKKLVYLYLMNYATTHPELCILAVNTFVQDTEDPNPLIRALAIRTMGCIRVQKMIDYMEIPLSRTLQDENPYVRKTAAICVAKLFNLNPQMCIEFGFLDSLKKLISDPNPSVISNVLNALYEINDMYISSNLNKELKLDILVLDYTLIKNLLVCLNECTEWGRLTILKCLNDYDSENSEQANHIVERIIPQLQHINPAIVLSSIKTILKHLVYLQKASQTSILKKLSSPLVSLISNPIPEAQYVGLKNIRIILEKYPNILSKELRVFFVKYSDPLYLKLEKLDIMIRLCNENNFNLLLNELKEYSMEFEPTLISKSIKSIGSIAIKLPTSIIKCVNLIIELIDLKGDELIIDESVGVLTMILRKYPGKNDLITLILPIIANNFSHLSIANPSYSSVIWLLGEYPNYFTNISNLLNEIFEDFNDFGSQLKLNWLNTIVKVNLNSLVKQDFSKLLQETLTEITENEDDVDLRDRAYIYWRLLSSAEQELPKQILLAKLPPIDSSIETYNPVILNDLMSELSTLSSVYGKPSYTFISNQPSSFFKSMDIDELKAQAKQDIIENVKNENLLDFDDDFEENGNASEGASTNSNNLLDELNDLFSNSGSSPASNTSTMKSNTDDILSLFNTLNVTSAPMAQPSQQQSQSSSNNDNKVNNDLLDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B270</accession>
    <name>G3B270_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113388</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B270"/>
    <dbReference type="STRING" id="590646.G3B270"/>
    <dbReference type="eggNOG" id="KOG3255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_1"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="191" mass="21783" checksum="6F8F1118945039F0" modified="2011-11-16" version="1">MKYVHTEQILEVPEGVTLEIKARSIKVTGPRGVLNKDLKHIDVTFRKINNKQIKIIVHNGDRKHVAALRTVKSLVSNLITGVTKGYKYKMRYVYAHFPINVNIIEEEGQKYVEIRNFLGEKRVRKVKVVDGVQIEQSANQKDELVLTGNSLEDVSQNAAAIQQMCLVRNKDIRKFLDGIYVSERGVVVEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3B286</accession>
    <name>G3B286_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113397</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B286"/>
    <dbReference type="HOGENOM" id="CLU_2903987_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="62" mass="6943" checksum="87059CE35933D61A" modified="2011-11-16" version="1">MDSYLVVSSIDRIKLSIFQIDFASQQDMPVPAAVESSARSPVKVSNKLSVPQEHDFYSKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B287</accession>
    <name>G3B287_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_92858</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685423.1">
        <property type="nucleotide sequence ID" value="XM_006685360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B287"/>
    <dbReference type="STRING" id="590646.G3B287"/>
    <dbReference type="GeneID" id="18250236"/>
    <dbReference type="KEGG" id="cten:18250236"/>
    <dbReference type="eggNOG" id="ENOG502RQ7J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536348_0_0_1"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="508" mass="58313" checksum="BC4394A8F5FAE914" modified="2011-11-16" version="1">MVDVFKLVSPPDGDEFRIPLILSELYAFINNDICEGIFRINGSLKKVNQYYNSLHRYHRWLPEANIYDVCSLLKKLLTTNYKFFDISKLDLGELKELSDEKFNWEYFNRFMNNNLNSLSLHIFMYTIAFTSRLLDHSDITKMSLLNFSIIFQPIFFSCDSLVGLPNYINLLNFLLKNHQKIDIDQSLIDSDFKLALSESSVETDFTDNSSFFYRFKSFKNKSIDSINDIGRKIPFSNDITFKGYRFNNRSVDMVSFLKDNRDSLSDQSKDEESAGTVITEVPENGPITNSESTQSVSSSTDPQIGSQDAQPDPEPESNPEYTHTLEPPTHKFPVFEIDESIDPLTVDPEINAVIHLKDIDTQSFQFDVDLDSSSNSSFHSLNDDSDDTSNQMNQSNFSNDTNDTSFQISELSHKPSMWSLRSHKEPKHSKHHESKTTRKKPTSKLAQTATRKRSSTILSRVESRLDSKSEPRSSCDTLSSMEKRRSLAKVFKNEGIKFPLKLKSKSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B293</accession>
    <name>G3B293_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridine kinase</fullName>
            <ecNumber evidence="6">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_129851</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="6"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B293"/>
    <dbReference type="STRING" id="590646.G3B293"/>
    <dbReference type="GeneID" id="18249406"/>
    <dbReference type="KEGG" id="cten:18249406"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_0_2_1"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="272"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="490" mass="55854" checksum="3D53C3735A589518" modified="2011-11-16" version="1">MTCSESDVSSESHSEPNTEGYFKDKTKYIPPWTEPYIIGIAGNSGSGKTSISQQIIRELNQPWTVLLSFDNFYRPLTKEQSAKAFANEWDFDTPDSLDLDALYDTVKKLKQGEKARIPVYSFELHGRTDKVTTIYGANVIIIEGLYALYDKRLLDLMDIKIYVDTDLDICLARRLTRDILYRGRDLQGAMKQWETFVKPNAVRYLNPTMNNADLVIPRGLDNVVAIDLMIGHIKKQLGLKSLAHIRHLKALGQDIEFDIHRYPNLKVLPINNQTMGINSILFNKNTLMSDFIFYFDRMATLIIEAALDQLTNYQSVDIQTDPNFPPFKGLQQRDNLIAVTVIRSGDCFVTSLKRTFLEIPIGKLLIQSDSLTGEPQLHQERLPRGIDNLKNKKILLFDAQIISGAAAIMAIQVLIDHKIGETDIIFCSYLSTEIGLRRILRVFPRVKIVVGKLSSLGDTSKFPKYNPEQFIDSNWHFKNRFIDSLYFGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2E6</accession>
    <name>G3B2E6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_92900</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B2E6"/>
    <dbReference type="GeneID" id="18250238"/>
    <dbReference type="KEGG" id="cten:18250238"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004883_0_0_1"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="120"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1160"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="767"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1410" mass="158880" checksum="D21B8D3478968072" modified="2011-11-16" version="1">MSSVSSTVQSPVASSGLTDDRCSQLIENTVQNTASEIPHDRSPPTSHSSPTSSHTMSEAKEVVQTSSHMSSPQPHSQKQHQQTGEKTSFAYNAHGESVFDDSRVFPSVKPGEIAKFDQGDPELINHATITALIVQLTSPEVIDYNLVYDFFITYRMFSDASTVMGLLMRRLVWSLQYVNKQDEESHKIGTLVLLRTFVVLRHWILNYFIDDFNSDLKLCDTFITNLNEVVFESGLINESMVFERKIIKDLKTHWLTLSSEFWNVHLDLSSFSGEEVFDYYLPATSDISMNSFLKKSNTEISLHTNPSYRRSAMLSLYDQKMHHKCLVFDDSRFSNNENPQLSVNNLLVSHKSSRQSIMNKLNHFNIGKSKHVSVKDATVNSAGSGPSNNNSNTTSPLGSSNRHNRMNLNDSSVGLRKTTKNRPTNQQSLNDEMDKISLNPIQIDNVGFSTNGNVKLPSSKVLSIVPSTPVKKMEYSIRNPLEKDDETAQGFSVNDWESPINYKIINSMDITRKNSIKKILEGWKKNRNHSNKSNDEINKMINDSITEDVIGTRIDVLSARIIDELEFLIRHYVQNDASYNPTIAEGDTIDNTNALNSPDEVDLHELDGSRDLDETHKPQNGDESVNDDVDINDVSELNLHKIDNLFSEQGDDDTDEDNEEFQDSGLSANMLNDIHEFSFQRPTSINWADDNALELDTSQTPAKEEGSDEELPEPNLPRDNSGDFNHLAEPPFPFIDGNNNFSSVSTISTPSNITDYNAEIEDLGIAMSPKSKEQQTKRISFSKHSSLKKRVSRNSSNSLFKRDSVKSYLSYDSAYSFSKDSLEDDRDNGHLRKKAGINDLRRMAGIPSERRSLENALRIQSNASVRKSVRASTLLALSELPFNGMYDSRSSIYMTNHKVIARSSGVGDSSIFSVAMKSRNSLSNSLKTLNESSRLSRTSPLNEDYDDFAFGFRASSDEGFGESETSTRSVVIPGISNNVLKELAAIPDDSFHFNPIDVAFNKLEGAKSQGKNLQSEEELNNSEVTQVELNDTQDILNEINNAHTEDIIESSSQKDFTAEMPLTPVAHRVIDVGDSSGGTLDSTQLEQGAKSDNVFIFSANYTTELEIISPSEESKTVSTVEPRLESPRLILESYNMADTSLAISNVMADNTHISFVLSYTSEELSQHFTMVERDILQEIDWKELVELKWNKELTPVNSWLEIIVNEEYYNSNKGVNLVIARFNLMVNWIISEVLLSKQQEERVQIISRFIHIAQSCLILQNYSTLMQILLALTSERLAKLRETWKSLPPGDILVLKNLEELASPVKNFLNLRVSINRIQPSRGCIPFVGLYLSDLIFNTERHKFIDKGKTVVNFARFRTSVHIVKSLSQCIEWSSYYKLNVNNELLSKCLYIRSLDEDEMNYCLKNVTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2M3</accession>
    <name>G3B2M3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_103753</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2M3"/>
    <dbReference type="STRING" id="590646.G3B2M3"/>
    <dbReference type="eggNOG" id="KOG0592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005768_0_0_1"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000534">
        <property type="entry name" value="Serine/threonine-protein kinase PKH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="206"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="503"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="561"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="888" mass="99066" checksum="8C843BD166FCDD02" modified="2011-11-16" version="1" fragment="single">MSNPNRLSYHPDPSSGSLKDINDDLDKIFNTYTSNYSNNSNDTLDSETAPPPISSTSKHHRLIPPTVLDRFSATNDYSVHISSRLSSLKQGSADVIHSAPQSPNSGSSFDFYSQDHRAMSNGSLDILNTPIIEQELKDIISPEKYGEVAKSNEALKSLNLEDDEIPSSIAVSGTKSEDWHERGAATRTVGDESNGFTVIRRNVTDFEFGKPLGEGSYSTVVLATDKITSTKYAVKILDKRHIIKEKKVKYVNIEKHALNRLSNRMGVVSLYFTFQDKDSLYFVLDYASNGELLSLIKKYNTLNEDCVRYFGAQILDAIKYMHDNGVIHRDIKPENILLDDKLRIQITDFGTARLLEKVSEESEEYPVDVRAKSFVGTAEYVSPELLDNKYCGKPGDIWAFGCILYQMIAGKPPFKAANEYLTFQKITKLQYAFSAGFPLVMRDLIKQVLVLQPSRRADIPTIQKHYFFQGINFDDFNQIWYSEVPELGPFKMSAKSMMKIPELSKSASSQSVATKRVPRKKDKRTVSEPSHNGNNNAKVSTASSAGAPLNPAAAAAFVLNKKEDSSDTEDSADTATDDIPNNTQTSSRTSSRAPSSAPSSAPLPDYIPGTNILRPTINSIHSYSRSSSRTKPQRKPKFKSKILEVSPITPLEVAWGKYLKSSDERILKIGPVIAHKTTTEQFERKYRGLIHESPLGFKNRGKGNSSFLSQVVSGNSTGLRDNQTLPVEEIEDDQDESKAIRDYFMIEEIPSSASSENAPTNTKISSKLFKRLGISNSKDKNSASEPVSQHPLEKGRTCTMLVTSFGRVLIFFRNDPEVNYRLISEVRLSYPFIQFKEVVTNSGRLSKILPTTGMFAIQSNVSTLTFEVEKYDVNHWTEALAKAQTNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2R3</accession>
    <name>G3B2R3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_113521</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2R3"/>
    <dbReference type="STRING" id="590646.G3B2R3"/>
    <dbReference type="GeneID" id="18247002"/>
    <dbReference type="KEGG" id="cten:18247002"/>
    <dbReference type="eggNOG" id="KOG1374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="64"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="494" mass="55270" checksum="8C3C7F8F98D0FFE4" modified="2011-11-16" version="1">MPGETITIQAGQCGNQVGTQFWSQLALEHGLLPDGTSTPYPQDQEQPEFDGQRAGTTNHREDRAELFFTLSDSGKYTPRSVLIDLEPSVIQRATNGFPMFNPRNIHLSETGDGAANNWSRGYAYGTQHVEELLEIIDRESDRCENLSTFQVIHSVAGGTGSGVGSYLLEELNDRFGAKKLITTSSIFPSSEKTSDVIVQPYNTLLTLDRLIDCSDWTTVFDNDSLNKIQNDVFGLSQTSDLQFENSNNAFNTTNKLISYVIASISNPIRFPGYMYTSYESILSSLIPVPELKFLSASIAPFADLSAFHSGSSKPHLSNMNEYDLILELLDDKYKMNKIGTTKPKYISMFTYLIGSDLNQDEIRKGKLKALKRLEFVPWTPSSISVVNGKKSPFMYGTHTSKHKNLNGLSISNNTSMVPFLIKILQQYDALAKRGAFINSYIDADTVGDKNSERERVLDNFNQCKEHVLSVIDEYKACQAMEFLEDDLLEVDEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2X0</accession>
    <name>G3B2X0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_104161</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2X0"/>
    <dbReference type="STRING" id="590646.G3B2X0"/>
    <dbReference type="GeneID" id="18245693"/>
    <dbReference type="KEGG" id="cten:18245693"/>
    <dbReference type="eggNOG" id="KOG0995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012583_0_0_1"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="73"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="269"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="489"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="634" mass="73945" checksum="E01D37F6F7FF816C" modified="2011-11-16" version="1">MNNVNGILPFPSSLSRKPNKRLSMASATRSSLIHSGTLPSGFRGGLIDSITTSVPSSIKRKSLASTPASLKRRQSSVPSSSQQSQQREEYSQQTVFNSSINTHDSRPLRDKQYQTLIQGEVYEFLRLNKFEVEMNHPLTTKTLKQPTQKDFIMIFQFLYNKIDPFYKFTKSIETEVFTILKLLNYPYLDGINRSQISAVGGSYWPTFLAMLYWLVKLNLQLSEINTLHQNSKSFDDQLNDIYDDYIKKTFISYSRYNNDEFGDIFEEFKTNFEQFNQKLQKEIDSQKSETTTLQSEFGQLNEKMKVYDNSEKKSRALENDLIKFKAYVETVESRQSDWERILQGIEAEIHNCRESSNAMIQEIETYETNLRNKGLDVEKINKLTNERSSLSESIDITNDKIEAITDQLQSKQLQLRSSYESLDNFIKHYNTLIYKMQYKNLTNHNFEVKLNELVWDLSKEFKPTEILDKNLKDEKIELIKFKNEISSRIHAIEDQKIKIQEQVDLLNEKLLEQREDLESLASKFTMDKSGYDQLYNSISDKSTTYSTKIERLTREINAIKVDASSEYLAVMHQYNDVGIEAETLKGSLYRQKNSLHNQIQKIIENTINFKLNIQSNLQDLEELVLRELESDQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3D2</accession>
    <name>G3B3D2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114165</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3D2"/>
    <dbReference type="STRING" id="590646.G3B3D2"/>
    <dbReference type="GeneID" id="18247297"/>
    <dbReference type="KEGG" id="cten:18247297"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000018">
        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="296" mass="32774" checksum="93382551194E0BAB" modified="2011-11-16" version="1">MSLSVTSKTFKLNTGASIPAVGLGTWRATEADAAYKSVKTALQNGYRHIDTAAIYGNEEEVGRGIKDSGVPRSEIFVTTKLWNKNHKDVEGALNESLSKLGLDYVDLYLIHWPHSTDPVTGKDYTDWDYVDTYKELQKVYKASNKIKAIGVSNFTIAKIERLLADKDVTVVPAANQVELHPLLPQDRLLKYLNEKGIYAEAYSPLGSNDSPLFKNGTVVSIAKKFDIEPAQVLISWAVQRGTVVLPKSVTASRVISNLKTLVLPDEEFEQLSKLSEKDGVVRTCDPGWHTYDDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3J3</accession>
    <name>G3B3J3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114229</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3J3"/>
    <dbReference type="STRING" id="590646.G3B3J3"/>
    <dbReference type="GeneID" id="18247323"/>
    <dbReference type="KEGG" id="cten:18247323"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017171_4_0_1"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="486" mass="54299" checksum="1D2B0CF5D38A339F" modified="2011-11-16" version="1">MTIAIATLLYDTSYLPGALLLGSILRDMIPLHPLDISLAILTDKSIFTSEQLGLLQEIYHQIIDIPLLDTHLTHKLVHDLQRPELGKTFSKVHLWSLEYDKVLYLDADTLPNPHSNLLDLLKLEFHDSKILASPDSGFPDVFNSGMFVIKPNKRDYSNLVQLIQSGGDVSFDGADQGLLNQYFNQNPDWVASVVDSNNTEVSTSASTSASTSTNNWISLPFLYNVTPNTQYQYAPAYHYFSGALAPFQTEPIGPPLPESTQEPAQVSAQSLYGNTASAHYGQHVKLIHYIGPHKPWKYPYNASHAEWWALWHKYFGTATLAILDGHPQDKHYTTKDSLWDAGRSSPPKSTSGAFGSIPNYGNSWDDKRKKKKSILKSGSVPPGPSRLRHVTVTDAHSESAPKDSTKLVNEREKQSVYGFHPFQRPERQFDQTYDYVPTHSLISKLKKTPEVTKEPAAPTTTTHAYSRAVNIDKVSEKLEQLGLDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3K6</accession>
    <name>G3B3K6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTEDRAFT_122462</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3K6"/>
    <dbReference type="STRING" id="590646.G3B3K6"/>
    <dbReference type="GeneID" id="18248902"/>
    <dbReference type="KEGG" id="cten:18248902"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_46_3_1"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000020">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="92"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="21">
        <location>
            <begin position="523"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV64177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="647" mass="73396" checksum="D72D416F455E524B" modified="2011-11-16" version="1">MELATAAVLGTQLLEAKYQVKGDFLLVQNIIRKALPFLWNVKKGKASYWYTYEKSVLKNPNNQCIAFPRPKANPPPVRIDDSGYKIYDDQFELETYTYKQFYDMVLRFSFILKNDYGVTGDQTIAISCMNKPLFLLLWLSLWNIGALPAFLNFNIKDKPLVHCLKIVNVSQVFVDPDCATPMKETEGMINSELPQVKLHYLNEKELFRILADESRPKYRAPDNTRRVNDQDHDASALIYTSGTTGLPKAGIMSWRKAFMASAFFGYIMKITKKSNVLTAMPLYHSTAAMLAVCPTLLVGGCVSVSQKFSATSFWTQAKLTKATHVQYVGETCRYLLNTQPHPDQKNHLVKIAYGNGLRRDIWKEFKDRFNIKGIGEFYAATESPIALTNLQFGEYGVGACRKYGSIINSVLSLEQRIVKMDPDDQEEILRNPATGLCEVADYNQPGELLMKILNPEKIESSFQGYYGNKDATSKKVIRDVFKKGDAWFRSGDLLRMDQDQLLYFVDRLGDTFRWKSENVSASEVENELMGSNAILQSVVVGVQIPNHEGRAGFAVVEPKQGLDEQQVLDQIYNHVSTCLPKYAVPQFIKFGQIEASHNNKVPKNQYKKQKLPKGDSGSETVYWLNKTKYEELTNDSWARISNGQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3L5</accession>
    <name>G3B3L5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114246</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3L5"/>
    <dbReference type="STRING" id="590646.G3B3L5"/>
    <dbReference type="GeneID" id="18247333"/>
    <dbReference type="KEGG" id="cten:18247333"/>
    <dbReference type="eggNOG" id="KOG1678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="204" mass="24418" checksum="7BCF5F2722FF37AD" modified="2011-11-16" version="1">MGAYKYLEELQRKKQSDVMRFLYRVRCWEFRQKNVIHRASKPSRPEKARKLGYKAKQGFVIFRIRVRRGNRKRPVRKGATYGKPTNEGVSQLKYQRSLRTIAEDRVGRKAANLRVLNSYWVNQDSTYKYFEVILVDPQHKAIRRDARYNWIANPVHKHREARGLTSAGKKSRGINKGHLYNKTKAGRYHTWKKHNTLSLWRYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3X5</accession>
    <name>G3B3X5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113911</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3X5"/>
    <dbReference type="STRING" id="590646.G3B3X5"/>
    <dbReference type="GeneID" id="18247177"/>
    <dbReference type="KEGG" id="cten:18247177"/>
    <dbReference type="eggNOG" id="KOG2837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030065_2_1_1"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="131" mass="14958" checksum="07120D134699C5E2" modified="2011-11-16" version="1" fragment="single">MARTSDIGTAKYQSKKLKAAGLSKLKFYCQVCEKQCRDANGFKNHLSSPSHKYKIESLSTTTITNYSRSLEDNFIKLLKTSHGTKPVNANKFYQEYILSDRDHIHLNSTKWNNLTQFLKHLGTTGKVKVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Z5</accession>
    <name>G3B3Z5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="11">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_104692</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="11"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Z5"/>
    <dbReference type="STRING" id="590646.G3B3Z5"/>
    <dbReference type="GeneID" id="18245747"/>
    <dbReference type="KEGG" id="cten:18245747"/>
    <dbReference type="eggNOG" id="KOG1380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_2_1_1"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="414" mass="46478" checksum="B38AAE5FE252A7C3" modified="2011-11-16" version="1">MSSKLLMVNRLNHINNFNFFFNNTKKRLVVSQNFLNNQYLLNQRHLYKNSQPASQSADSKRVLHEVTSKVLTCQDSHIPFKVTPKKVAIEETSLKALIRPYIKLTKPNLTVLVMLSSISSYALSPYTVSIQELMFLAIGTTLCSGAANAINMGREPEFDRRMVRTSNRPIVTGQLTSTQAYQFAAATGALGAIMLNYGVNPTVAILGVMNIVLYGGIYTTLKRKSIINTWVGALVGAIPPLMGWAASSSLWHPGAWCLAGLLYAWQFPHFNSLSHNIAQQYKDAGYIMTAAENPRLNARVSLRYSLLMFPICFGLSYFDVTDWMFSVDSSIVNAWLAYLAYQFWSQQKINYQSAKGPTVEGLQKANVHARKLFWGSVYHLPAVLMLAMVHKKGQWDRLFTYLGIYEGENNKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4P7</accession>
    <name>G3B4P7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_134571</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4P7"/>
    <dbReference type="STRING" id="590646.G3B4P7"/>
    <dbReference type="eggNOG" id="ENOG502R9P3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304024_0_0_1"/>
    <dbReference type="OrthoDB" id="5103085at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="4">
        <location>
            <begin position="283"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="3">
        <location>
            <begin position="847"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="505"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="978" mass="108736" checksum="3BC611A698467D09" modified="2011-11-16" version="1">MRRKTTVSSVSVSNGKSKQALTGVTKPKIKNRLGRPPKLTVGDNDSNGDDAVSDVDSDSDNDSDSDDDSSSGSSSDDDINYAEANEEFVDEEDDVDDDVEDYYDDDDDYDIAFPESTPRYLLKIYAGLFRVSGNPKFENKAINAMMETALSIALPTKPEERKEIDLSDLSFTKGSDIHSPDVLVIQLKSGRNIEGYRHKLPLPCLIGTIARNLWYRLDFPQGPLAKDNFPNFQDGSYRQIKLLYSQRSDSVRPISEQNMMSLAKFSFDQAFGNMSNSRVSFYVNSLQEFPRLEAAGFKPPETYFIARDQVKPPEQLRKKVFPWLESEWQSFEKYQSTLPPPIRDLSLPKLFYMLDQFRDIILQDMVFLVDQNPECVFYYYEVCYCPEFVAYKKDVLAYCGQTEPVTTEVKSRAPENRPRIRSSANHTPTRKPAHKSTAAKKAYQTQLTLQSVFDSRSSVEDSSTKNSLNNQKITKSPVNRGKQATVSHSDKKVVSQSESKTDWLIQNMQEQNQSLRNDILAIKEQTLQQKQEVEDLKKLTQEKLNAIFVLLSKQPEALSSAYKNTQGANIQATPPTPHWGTQVAGQIGQAAGQIGQVAGQIGQVAGQVGQVTNQLPGQVAQLPGQVAQLPGQVAQLPGQVVTQLPGQVSAQVQAQILGQVPGQVSGQISGQVSGQTSAQTSGVSSASYPGYSLSNAQFPASTTYLTYPYGYQSVAAYYPQQSSVQFQTSPGAYTIAQTAAPTTPVSVQPPSTPAQSTSTSASAKLTLAAPVTSTKTKTKAPPVPSPVIGTEAAFQLPPDSLVRFTQWTSEQPHIQPPKRSKAKRPDYVQRLEFNESLEKASHMPKVAKTLVGYVRQWFLGMEGVPSIVSRDQVFKDAWRQQTAAAETYSSRRKIVDFVESLRKDTGTLFYGWGRFQLAKLIDIHFSKNDIPITDLEDIGSKEKRDLIRKLYKLKAVTPHEMYTNFSFDLKSEFKCKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4R8</accession>
    <name>G3B4R8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_121611</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4R8"/>
    <dbReference type="STRING" id="590646.G3B4R8"/>
    <dbReference type="GeneID" id="18248858"/>
    <dbReference type="KEGG" id="cten:18248858"/>
    <dbReference type="eggNOG" id="KOG0334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_0_2_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="264"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="476"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="635"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV63856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="809" mass="90128" checksum="043B2164DAACF763" modified="2011-11-16" version="1">MNATNDAEKHRQRQEKLAAWKQKKLQKGNADDDDKKRKRLELWRIKRLGKSTDSSSPTKSATDGAPKAKVMPTLKLTKVQKPKIDTAKRSIFGDEDEEDDTRPKFKKPTLGTEETPKKATDEEEDIDLDMFIESISKNDTPTKVVLQSDNEHEDEDFEEDSDTQNDILSSKLKKLQEREKALETVDHSSIDYKPFRRVFYKPPKEFESLSSDEITKIRQDIKVKGVDCPLPITKWSQLGLPLSILSIFKTLNYETPSPIQCQALPTIMSGRDIIGVAKTGSGKTLSFVLPMIRHVQDQDPLQEGDGPIALILTPTRELAFQVNKEISNFSKSVSSCCCYGGSSIESQIAELKKGVQVIVGTPGRVIDLLTVNSGRVTNLKRVTYLVLDEADRMYDMGFEPQVKKIISQVRPDRQTVLFSATFPRKLEKLAKHGLNNPVEIIVGGINIVASEIKQKLELFEVGSLNEEEVNRIKFMKLVEVIDGFIKENENSKVLIFVEKQDSADSLMVQLISSDYNCVSLHGGKDQIDRKFAIKEFSSPDSGLDILIATSIAARGLDVKGLDLVINYDAPSHLEDYIHRVGRTGRAGKNGTAITFITDQQDRAIADIIKVLTPPIDPRLNKISEEFIAKVKSGKEKYSSGFGGKGLEKLQQQRDSTKDLERQTYEEKSSTSVSVSTTPISTTKPATEELTSNLPDFDIVEGIPSDSSGPDRSKFHSRITINDLPQTVRWFVSNGESISKIIESTSTSITHKGQFYANGKAKKDGPPKLYLLVEGLTHGAVQEANEMIKQRMIEGLQTANQSGSTGRYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4V0</accession>
    <name>G3B4V0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="14">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_105173</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-2,3-epoxysqualene = lanosterol</text>
            <dbReference type="Rhea" id="RHEA:14621"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="EC" id="5.4.99.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:14622"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="14"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4V0"/>
    <dbReference type="STRING" id="590646.G3B4V0"/>
    <dbReference type="GeneID" id="18245788"/>
    <dbReference type="KEGG" id="cten:18245788"/>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000027">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="16">
        <location>
            <begin position="85"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="15">
        <location>
            <begin position="386"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV63876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="730" mass="83496" checksum="61767BE84558E553" modified="2011-11-16" version="1">MGRTYYSDRLGLPRTDSSRWRLRTDDIGSEWWEYPDKNDLEKDPQSTFARYLLDQDSFPAPEPEAIKTPLQAASKGAEFLQLLQDDCGSLPCQYKGPMFMTIGYVVACYFSGTEIPEPYRIEMIRYLVNASHPVDGGWGLHSVDKSTCFGTTMNYLVLRLLGLDANHPVCVKARKTLHRLGGALGNPHWGKVWLSILGLYEYEGVNPAPPELWMLPYWFPAHPGRWWVHVRAIYAPFGYIIMNKVRMEMTPLLQDLRNEIYLPSQLPYENIHFSEHRNNVCGVDLYYPHSKILNFANKLLVVYEKFRPDWIRTLASKHVYGLILKDYANTKHLTIAPVSFALDMVVTFAVEGKESENFKKLNSRKNEVLFHGPQGMTVMGTNGTQTWDAAFMIQYCFMAGLADIPKHQPMIKKAFRYLIRNQFTDDCVEGSFRDKRNGAWGFSTKDQGYTVSDCTAEAVKAIIMVKNHSAFSDIKDEIADDRLFDAINVLLTLQNRGSYEFGSFSTYEKIRGSKMLESLNPAEVFNNIMVEYPYVECTDSSVLGLTYFTKYYPEYKQIPIKFAIEDAINYIRKAQNEDGSWYGAWGVCYTYAGMFALEAFNSVGRTYENDPVVKKGCEFLISKQLSDGGWSESMKSCETHSYVNSNQSLVVQTAWSVIGLLLADYPDKTPIKKGIELIMKRQLPTGEWKFEDIEGVFNHSCAIEYPSYKFLFSIKALGLYSKKYGDEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Y0</accession>
    <name>G3B4Y0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114047</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Y0"/>
    <dbReference type="eggNOG" id="ENOG502TE7V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2793931_0_0_1"/>
    <dbReference type="OrthoDB" id="4085733at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="67" mass="7522" checksum="749C72AD383E90FF" modified="2011-11-16" version="1">MDQGRLSHILENTYIPPKKSLATPQVPPYHPCLIVQDKQTDVTKIKPCGCADSYCVKMAPEWIPTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Y5</accession>
    <name>G3B4Y5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_105097</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Y5"/>
    <dbReference type="STRING" id="590646.G3B4Y5"/>
    <dbReference type="GeneID" id="18245778"/>
    <dbReference type="KEGG" id="cten:18245778"/>
    <dbReference type="eggNOG" id="KOG3000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041744_2_0_1"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="3"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="13">
        <location>
            <begin position="194"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="120"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="311" mass="34067" checksum="42CBAB856E68DE5A" modified="2011-11-16" version="1">MVGESRTELLKWLNNTLDLSYTKVEQCGNGAAYCQLMDSIYQDVPMARVKMGAKTDYDCSTNMKILQASFQKHGVSRNIDVDRIIKCRLQDNLELLQWLKKYWMERKDLNIEYDAVGRRQGRTAAPTPGSSRQVSSAGGSVRSVSASSRAPSAVGSRINAGPRSISGPVSSSISNGSSGGATATSAKVVQLTKQLAEARTHIEELTAELQHVKEERDPLEIERNFFYNKLISIEELVNITKEAVANNQQTVVLGDRTIGAGSMELIDEVYAILCATQEGFEISNGDDDGVVAADVEMSVEADRFNLEAETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B501</accession>
    <name>G3B501_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rhomboid-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_98026</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B501"/>
    <dbReference type="STRING" id="590646.G3B501"/>
    <dbReference type="eggNOG" id="KOG2980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034022_2_0_1"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000012">
        <property type="entry name" value="Rhomboid family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="124"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="286" mass="32089" checksum="EC57BBE5D8FC7739" modified="2011-11-16" version="1">MMRLFGRFSPSRGLRLLKFKHQRRQQRRDSSTWSRYNKHYGNSNWDRLKGPALFTLAFCVGTTLGVPLLMKFTPLGILTRNPSWLIYSIIAANGLVFLMWKNPNFITFMSRYGLLVKDKMYSNWSLLGSAFSHQSFMHIFVNMFVLQSFGTSLCAMLGATNFLVMYLNSAVIASFVSILVPTLMRTSLAVGSLGASGAVFSVVGAFSYLIPKAPIALFFIPVPGGAWFAFLGAIAYNAAGLFFRWGAYDYAAHLGGSMAGVAYGWYYTKKMREQRARARTIRPRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5A2</accession>
    <name>G3B5A2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114491</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687366.1">
        <property type="nucleotide sequence ID" value="XM_006687303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5A2"/>
    <dbReference type="GeneID" id="18247445"/>
    <dbReference type="KEGG" id="cten:18247445"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="249" mass="25996" checksum="63054310EE950A60" modified="2011-11-16" version="1">MSFTYLVVGASRGIGYAYVKVLSAVPTNLVIATARDHQSAKKLESLGSNVKTILIDMQDPYAKFEAAFKVLDTLAPNGVDVFIHNAGISSSDASKSSLEFDADQYQKILDVNVGGPAKAYKAAYPYIFKGKGTKKIAFVSSTVGQVGWEVSPGGGQGFNAYGASKAALNHLGVQIAKENAGSDVDLVKHSVTVLLCPGLVATDMAKGFEGAMPPEVSVAASLAVISKTTAADSGKFYGHSGESQPYSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5P9</accession>
    <name>G3B5P9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DIL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114573</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5P9"/>
    <dbReference type="STRING" id="590646.G3B5P9"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046436_0_0_1"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="1">
        <location>
            <begin position="15"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="367" mass="42414" checksum="EE0942FCD327CB25" modified="2011-11-16" version="1">MWRLGLTKESEEFLGEVLATIQVIVSNLKGDDVIPNGAFWLSNTHELYSFVSYAQQTILSNDTLSFEMSEEEFEEYLKLIAVVKEDFESLSYNIYNMWMKKMEKDLEKKAVSAVVLSQSLPGYMAPENSPFLSKVFSPANQYKMDDILSFFNNVYWSMKSYFIEQEVMHEVLVELLRFIDALCFNDLIMRRNFLSWKRGLQLNYNVTRLEEWCKGHEIQEASVYLCHLFQAAKLLQIKKNTPEDIEIIYEICYALRPNQIQKLISQYYVADYETPISPDVLQAVADRVKSSGDAGTQELFELVSTDGYFNDPFRTVSLRPFSRVEAYVPAWLTLPVIRRIVELVAKNATAQEALGDKERSSEPSISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5R7</accession>
    <name>G3B5R7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_106283</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5R7"/>
    <dbReference type="STRING" id="590646.G3B5R7"/>
    <dbReference type="eggNOG" id="KOG1537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_2_1_1"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="13">
        <location>
            <begin position="70"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="353" mass="38371" checksum="3BFAA89016556DAA" modified="2011-11-16" version="1">MVPSPFTLKVPASSANIGPGFDVLGIGLNLYLEIDVRIDPSVDTSEDSFHGRLSYEGEGKEGVPLDTGKNLVTQTALYVMRCNGFEKFPMGTHIHVKNPIPLGRGLGSSGAAIVGGVMLGNEICQLGFDKIRLLDYCLLIERHPDNIAAAMLGGFVGSYLNELTTKETNDKSVPLEYILPKDSTPEEKIVSTAPPKDIGEYLKYNWNHKIKCVAIIPQFEVKTDDARAVLPDSYTRSDIVFNLQRLAVLTSCLGQDPPNSKLIYNSMKDKVHQPYRASLIPGLTEVLQNITPSSVPGVCGICLSGAGPTILCLATENFNTIAETIIDVFKSSNVNCQWKLLDLAYDGATVSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5S7</accession>
    <name>G3B5S7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114592</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687086.1">
        <property type="nucleotide sequence ID" value="XM_006687023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5S7"/>
    <dbReference type="STRING" id="590646.G3B5S7"/>
    <dbReference type="GeneID" id="18247494"/>
    <dbReference type="KEGG" id="cten:18247494"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029626_0_0_1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="78"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="452" mass="51743" checksum="8F95FEDAF2B9D5CD" modified="2011-11-16" version="1">MDEVSHNRLYGPPQRLPLKSYPRELESLETIGNKKLIKDYKKNIKSFMARLESNNDINPAMIDLQPEIQWFMRPFLLDYIIELHGSFRLQAQTLFRCFNIIDRYCAKRIVFKRHYQLVGCTALWIAAKYEDKKSRVPTLKELSIMCRNAYDEEMFIQMERHVLSTLEWSLERPTLEDCLQLAIDSFIGFDSITPIRNSSDNSIVSATTAVTRFLCELSLYHRDFLNFETCIVASAANLLALSMLKVPHGANYVLGLISTKLRVEANADTEDLENVEPEIYGSFLTGFDEHTLIKVRRVSLMLAIFLEEASEVLTTKYKPLGVMSVVENFIDTNHQIFEKLRVHKTDVTKIDEENFEANTPITLLVDILLNMHESYDGEFVHDAPITPPSISRSIFSDLQASSPSFGTPTVYNIGKGSQSSLHDIREPQSCKTSFAYKFSPDRETSAVRMGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5T8</accession>
    <name>G3B5T8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxysterol-binding protein-like protein OBPalpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_98445</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5T8"/>
    <dbReference type="STRING" id="590646.G3B5T8"/>
    <dbReference type="GeneID" id="18250773"/>
    <dbReference type="KEGG" id="cten:18250773"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_1_0_1"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="401" mass="45461" checksum="A11A2ED1395EDE4B" modified="2011-11-16" version="1">MGLTSKLRLRKDNSQDSVDNGSQSADDVDEMDNENQSILLSIIAQLRPGSDLTRITLPTFVLEKKSMLERIGNAFFTPQLLLEANGTDDPLRRFMLIVIWYLSGWHIAPKAVKKPLNPVLGEIFSCYWDDLPENKKAFYIAEQTSHHPPKSSYFYLLPESKIKVDGVVVPRSKFLGNSSAAMMEGLARLTLGEHDEEYTMTQPNIYCRGILFGKLKYELGDQMTIKCEKLGFEASIEFKTKGFISGDYDVIEGVIKDSSSQKILASVSGKWNEVMTISPTDVKLEPIVLDTRKASVNTPSVKPLEHQADNESRKLWKKTIDALHKRDHTVATEEKFKVEEAQRIRAKERVANGEDFVPAIFKPVQDDVPFVLRKEMNVKDEDPQYLIHELLDLHPITGFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5U5</accession>
    <name>G3B5U5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">pH-response regulator protein palH/RIM21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_123398</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5U5"/>
    <dbReference type="STRING" id="590646.G3B5U5"/>
    <dbReference type="eggNOG" id="ENOG502QWMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026111_0_0_1"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="519" mass="59134" checksum="7A5B618F67F6CB77" modified="2011-11-16" version="1">MSWRNTEWTRPYASCEELELPSGLLIPQSQKMHIFINQALYKMNCYENATPRMSASDGKLESTYASNLPIVDYSWAQFTRHYSKGGFEYSVVPIIYSVSASAVITWFLTIFILTSYTIKSSLLLKSSTILSSIFLMIVMIRGIYELDFEQKNGYLSGLGFLDTLNNSLYLKIFDFLSVLLLQINQVQVIMRLFSRQNDKRLILSLGLTASLSSQIIWAISKFHDFGSSSETGYILPTFIYLTRTSMAICYASLITVFLILKSNDIIAHRNIWLITVLTLIVICGPVAFFVADVANAFVYELSDIFSVVTYVICVVIPWEWCNRYNMIMRMKEKEGVLGRRFFEDEFYHLDGLELFVEDSDPENDNNENQAGDSQNRGKREGRYVSLQKKVSRLDDPPTTLMNMWGKTTSAFVGIADAIIATGFAIPRSVSVPSASGSYNNNNDHRDPETIPLDDLTSGTYPAAIVGVEHQARTLDINTRNRRDIFVYSTKQVTINFSDDDENNDNHINYQNHNNHERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3B650</accession>
    <name>G3B650_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_105899</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B650"/>
    <dbReference type="STRING" id="590646.G3B650"/>
    <dbReference type="GeneID" id="18245851"/>
    <dbReference type="KEGG" id="cten:18245851"/>
    <dbReference type="eggNOG" id="ENOG502S2FW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_7_1_1"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF18">
        <property type="entry name" value="MALTOSE FERMENTATION REGULATORY PROTEIN MAL13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="525" mass="59417" checksum="6081BD9F1436F7D4" modified="2011-11-16" version="1" fragment="single">MSETPQPHDSSAARPQKPKTKRSIRAKYSRPCDGCALRKVRCDQQKPCSRCVEHNVPCTDNRLKKKCGPKHIHKKTRDSINNLSMGNAKINTLGDHNQILTLDKLLPCLQIYQTWYYGIWPVLSVAHLVSRIVQLNPNSDSTLSKENATSYALCCAVCAAITRQLTFLTAGNPIVGAPANIDASQYAKEAIRARNLFDYRLDPSHDNLLISFFLYIYYINIKDGIQAAILYMKEAISIAQLLGLHDPRTYSARPTAEVHRLRKIYYMLLVTERFSCIEDNVPVCLEPSIPLPSLEDEEYSGLLTGFIELVKIFSIPDKRFFDNLINYSKKNPGNLNNFQNLFVSSGTPTRKWITDVQVRLSKIEVTNASSDTQRLNIILSKHWMRALAWHISSQNGLLIKKDTDSENPCLSYQYPIEIAKDFLISTENLPIFAFESNGPGVSVKLLEIALAVADSVNECIINKSEYFTAYNLLTSIFNLVSKFKSEITISEELYVKVESIVRRKSMPSPIYPKSYIREVNNDGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6F6</accession>
    <name>G3B6F6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_106787</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6F6"/>
    <dbReference type="STRING" id="590646.G3B6F6"/>
    <dbReference type="GeneID" id="18245916"/>
    <dbReference type="KEGG" id="cten:18245916"/>
    <dbReference type="eggNOG" id="KOG3230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="224" mass="25247" checksum="1CE81EAC539D30A9" modified="2011-11-16" version="1">MSQIFEWAFGKKLTPQERLRKNQRALEKTQRELAREVAKLQQQEKKLIGDIKKSAKSGQISSAKVQAKDLVRTKGYITKFNSMKAQLQAISLRIQSVRSNQQMATSMRDATRVLSGMNRSMNLPQLSRIAQEFQRENDMMDQKQEFMDDAIDDAMAFDDDELGEEEQVDEILSQVLDEIGVSLNATLQDTPSGIASGRPEPRVAQAVAAGEEDDLQARLDSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6G6</accession>
    <name>G3B6G6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_106234</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6G6"/>
    <dbReference type="STRING" id="590646.G3B6G6"/>
    <dbReference type="GeneID" id="18245870"/>
    <dbReference type="KEGG" id="cten:18245870"/>
    <dbReference type="eggNOG" id="KOG1875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283151_0_0_1"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="10">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="948" mass="110116" checksum="616ECEA35EAC0750" modified="2011-11-16" version="1">MDSSTVVVGAELPHVTSNIIPLSSVLKFYCHEAYKQLNTMVENLSITRNKETDVTRKKKLLTLIVGLRQDFIKIYALVKWASKAQDVGKLIDLLNWFRTQEFYFEQLALGLNELNGFSGAKLPNSDLTTSMEVLIKGRPQLPSYNLIKNPPISSQKILKVLQDLNLALTARIALNDNIPSELLVNHQVKDGRIVFKLDKKYEACVTVANDLIIESDEEYSRSPYFLIDFHFAFGIDDDNVLKSNLPTPLPQSFWTKLEKQGNSVLLSSNLQGLYRFLNNFTKKFKFNLIYQQQLKSLNDLKWKNLKYKYADNKILINYWNNPSNTIEITLNEDFEIEFKWFKNNEIMTNLQDISINNDEFNIEYLLNLILNKHCGILASSISRTNPTFFKLINPYQVLIKLTNSKPSILSIDSLTGNFYFTEPNAAQAHITKRINSFNYNGSESSLIQYIHNKLIELKLDTISSEIKNKLITIEWISNHIINLKENELRKLDKDLVGTAFNIQYFKCKNWPSSWFLISVVDERDFNIDWFVSRIKSIKGEWKLEWVTNLGLIDSQLNFEFFNNLSVVCSNKIIDNMLTQELTIKNVKFIELAANHSLLTQFHMESNSGKRNYELMILIYNGGEYLPVKNSSNSLILKIELVNNKESKLIKVRLMSKLKLDSSKFNNLNLDNIKILERGGQQFIEIFQEINLGNNELNLDVNILEGVFGSLNKLNYLITLMNEVIENNVEVLEFNQCIKIKINEVFKQVYIEVPEKGMRNYHYRYDENEANDIKLIINYINKSISYDKPYSLLSVINYFNQIMPLIQGIRKLRTHVDTKAASHKLSNGLCKLNFDLKFVNLNNLQLLFGLNYYNPNNTKKVQRDKIILTMRFKLNKFRVGNQLEMNLSLLDNINIKNLKYKKLFEMIFKSLNKYEDAVNLNYDFIVGMPVVSEFLMDVGNCFLEYVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6M9</accession>
    <name>G3B6M9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_122579</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6M9"/>
    <dbReference type="STRING" id="590646.G3B6M9"/>
    <dbReference type="eggNOG" id="KOG0297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019709_1_1_1"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="72"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="463" mass="53461" checksum="4AD201215734D3E5" modified="2011-11-16" version="1">MKDYLEELEEIEKQLDSLHPQDELTITSPVSTDEYCDTPINNAPNSFNIEHSYDKPDLRNLVYVGQTDHLQCPICQQPFFNPYTTLCGHTFCRECVLECLKMSKDSDSDTLGVCPLDRTPIDATNSGDLFPTPILINNLVDDLKVYCLNSGRGCDWVGCRWEVEHHILADCDYTGVRCNRIRDDDSLCDVLVERRYLKVQVKEEEKQKPECVHKIYKCSLCKDEITKVTEEEHLQNDCLFNYQTCGICANDMIPMKSLAKHQDSCTKASKFICPAKEIGCQFIGNSLPSLENHMENNCTLNQFLPFYKTMDEKIGSLTTENAHLQRQINQILNSVIQGKITNLGYNEPLEEINRFKNLDSGDQDKLVYLSYEIERLKYQMDEKLLPFVSKQTNEREPVINNLVNDSFIMKDDLNLQRMLINSLRKQIQFILFKNHRPSFNGLNSNPIFDDDLSDSDERLNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7A8</accession>
    <name>G3B7A8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115066</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7A8"/>
    <dbReference type="STRING" id="590646.G3B7A8"/>
    <dbReference type="GeneID" id="18247705"/>
    <dbReference type="KEGG" id="cten:18247705"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="433" mass="46966" checksum="9826DC5A23634233" modified="2011-11-16" version="1">MSESHISSVTAKQYEEEYSAHNYHPLPVVFSKALGAHVWDPEGNEYLDFLSAYSAVNQGHCHPKIIAALVEQASKLTLCSRAFSSDVFGQYAKYVTEFFNYEMVLPMNTGAEAVETGLKLARKWGYIKKGIPENEAIILAAENNFHGRTLGIISMSTDPEATTKFGPYLSGVGPQIPGESKGTLLRYGVIEDVETAFKNAGDKIAAILLEPIQGEAGIVVPPKGYLTRVQELCKEHNVLLICDEIQTGIARTGKMLCYEHSENVKPDIVLLGKAISGGVTPVSAVLSSKDIMLCLEPGSHGSTYGGNPLSCAVAMAALQVVKDENLVQRSQQLGDLLFEKLEQLKKEFGGIIAEVRGKGLLSAIVIDDTKTNGRSAWDLCLVMKDHGVLAKPTHDHIIRLAPPLVISEEDLLKGVEAIKQSLIKLPNAPKAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7F3</accession>
    <name>G3B7F3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA repair protein RAD16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_125943</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7F3"/>
    <dbReference type="STRING" id="590646.G3B7F3"/>
    <dbReference type="GeneID" id="18249139"/>
    <dbReference type="KEGG" id="cten:18249139"/>
    <dbReference type="eggNOG" id="KOG1002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_1_1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16567">
        <property type="entry name" value="RING-HC_RAD16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000753">
        <property type="entry name" value="DNA repair protein RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001864">
        <property type="entry name" value="DNA repair protein RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="216"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="558"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="647"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV62261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="93095" checksum="E7D3B5E636B8F5E6" modified="2011-11-16" version="1">MSSSDISDTDTGGGFIVDDNNFASNKRRRTRAKPANVSYKEDSDIEEIPDGTAVLTPQTGRNGSRTRQTRKNTPKKTVKKVVESEDDDEEFTLEGAPEEEDQDDEDDIQILQESFTEPAGITELDAIEISEDEIPLAEVKKPAPKKRARKKKEPKVKIPYFTRITERLYENHPYLKDVFPYLDMLPGIEPERAPQPSGMSIKLLPFQLEGLNWLIKQEDGEFGGGILADEMGMGKTIQTIALFMNDLSKGPNLVVGPTVALMQWKHEIESHTNNKLKVLLFHGANRSSDVSELSKYDVILTSYSVLESVFRKQNYGFKRKSGLVKEKSPLHAIKFYRVILDEAHNIKDRSSGTAKAANNLNTEKRWCLSGTPLQNRIGEMYSLIRYMKLRPFHEYFCTKCDCSSSEWLFSDWRHCDICGHTPMVHTNFFNHFMLKNIQKFGIEGDGLVSFQNIQLLLKNVMLRRTKLERADDLGLPPRTVEIRYDTFNEEEKDLYISLYSDSKRRFNDYVAEGVVLNNYANIFTLITRMRQLADHPDLVLKKAGNNPISNEVSGLIVCQLCDDEAEEPIESKCHHKFCRLCIQEYCDSFGGDSSKLECPVCHIGLSIDLQQPALEVDEQEFSKASIVNRIQLGTHGNQWKSSTKIEALVEELYKLRSDKHTLKSIVFSQFTSMLDLIEWRLRRAGFQTVKLQGSMSPQQRDNTIKFFMENAQVEVFLVSLKAGGVALNLCEASQVFLMDPWWNPSVEWQSMDRVHRIGQKRPIKITRFCIKDSIESKIIELQEKKANMIHATINHDQAAINKLTPQDLQFLFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8J8</accession>
    <name>G3B8J8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipid droplet-associated hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_109251</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687920.1">
        <property type="nucleotide sequence ID" value="XM_006687857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8J8"/>
    <dbReference type="GeneID" id="18246096"/>
    <dbReference type="KEGG" id="cten:18246096"/>
    <dbReference type="eggNOG" id="KOG3975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018394_1_1_1"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37308" checksum="870AE4490264F341" modified="2011-11-16" version="1">MSLETLEEYPLTSVYRKPALKPSAVPELLIFIPGNPGLVEYYITYLELIQQAHPTFEIYCISHAGYQTTGDYVKEGSKKYPVYSLDFQVKHKCKIINDILHQKGGKANLYIMAHSVGAFIVQRVLKILEANRDVLVKFVGLICPTVINIKESTSGQVLSKLSTYLPLVQLGLVFSYVLGFLFSNNAIKWMFRNFVFSSPKSATRNAAEALENSVSASVKLVTSGRIVKQTLTMAIEEMEMILEDDELNDWFFQELSAQGTKIWTYFAFTDHWVHDNTRNYILSKYHDESNPNLSFELGDVDDGITHSFCVDQSEEFAEITLKMMNQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Z7</accession>
    <name>G3B8Z7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_94695</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687985.1">
        <property type="nucleotide sequence ID" value="XM_006687922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Z7"/>
    <dbReference type="STRING" id="590646.G3B8Z7"/>
    <dbReference type="GeneID" id="18250425"/>
    <dbReference type="KEGG" id="cten:18250425"/>
    <dbReference type="eggNOG" id="ENOG502RQ02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621148_0_0_1"/>
    <dbReference type="OrthoDB" id="4007944at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="389" mass="46136" checksum="EB25DE27A5FC7A78" modified="2011-11-16" version="1">MDSEEVVDNFVHKCWDTVSKGKDYIYVLQLRELISELELQLNGQNFLKHDETKLLNEMIQDKPTLKLYKSELKNFVLKLVKHTSLLRFLTERTGISRANLVSLITNPSKSYPLSPNQTVNHMSRPFMKRGLGSFKSMNMQENQVNQREDHISLISRENSDLQSSNKEHQFRIRSLEKQNQSLKDYIETLEKEARSTSIVTSTKGNKSQDSVTRDLINQCNQRDKTIKVLESMCEQYQKEFEKLKENSVIKNLTANLEQQNQLIDSLQSKLRLQSDNHSEELQQFLFKIPLLKQYRMYYRYKEQHKNVGIVFVNVVTLIITCIIIMTILRIFYFITLNVFNNHNSGAEYIYDTYGINHWGDEYPVSMVWWKEFQWLEYLAYQMGDWFETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B937</accession>
    <name>G3B937_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_108527</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B937"/>
    <dbReference type="STRING" id="590646.G3B937"/>
    <dbReference type="GeneID" id="18246036"/>
    <dbReference type="KEGG" id="cten:18246036"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005688_2_0_1"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="124"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="314"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="640"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="759" mass="84798" checksum="2EEE3611311F6D14" modified="2011-11-16" version="1">MYHPFAFQASEDEIDFRSTFLSALEVNLASNWSKIYTAEPHLAGTNYGLVNFTKEKFEEYGFKASVDDYEILVSYPNEHALNLLEEGDVIYTAPLQEDVLEDDETTGGDDLIPTFLGYAANGNVTAEYVYVNYGTKDDFELLKGLGVDVAGKIVVARYGSIFRGLKVKFAQDNGAIGVLLYSDPGDDGGITEANGYKQYPKGPARQESSVQRGSVQFLGGIGAAPGDPTTPGYASKPGCERQDPHDSIGKIPVLPISYREVKPILKKLNGHGVKMTQENWVGELEGFEYYTGPNKKTELNLYSDQFYNISTLTNVYGEIEGEIKDEVIVIGNHRDAWIKGGAGDPNSGSSSLLEIARGLGELQKQGYKFKRSIVLMSFDGEEYGLLGSTEYGEYAAKQLSKKVVAYLNVDVSVSGPVLGLQGCPSLYSVLKKAASILPYPEEGVGSLLDHYISHNGDKIGVLGSGSDYTVFLEHLGIPSVDMGFGPVKGSAIYHYHSNYDSYHWMETYGDKGFVYHNLMAKYLGLVALELSDREVLNLKVADYADYLIGYFEVVKKKIPKTWLKERIEDPDTLKNLLTYSEDETSFMKSTAHGYYKAKSPLPFPEFLKHGMCPKHQGSIMHLLEDHEDVTLGDLLDSTITDLEKVKETTEAFDAKSEDLQLQFDDRYSLPFWSRFKLRFLIIKQNKLLQYFERNFLTHKGLHQREWFKHIIYASGRFTGYAGQVYPALQEAIEDNDFDRLVDGLGVVSKTLRRIYGELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9M7</accession>
    <name>G3B9M7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_125279</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9M7"/>
    <dbReference type="STRING" id="590646.G3B9M7"/>
    <dbReference type="GeneID" id="18249094"/>
    <dbReference type="KEGG" id="cten:18249094"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_2_1_1"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="329"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="391"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="460"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="755"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV61928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="816" mass="92310" checksum="66A3A81ACAB80380" modified="2011-11-16" version="1">MAKSKSSKAPIQKATVSVDDPIDDLSFSNGPSRPFLNTTPSLDVVKARKLLPKEYLLLASLVVFAVNIRLADLAFPNSVVFDEVHFGGFSKKYILGTYFMDVHPPLAKMLFAAVALVGGFKGDFSFEKIGNEYPEGVPFQLMRIFPALLGIGTVLLCYLTLRAGGCRPTVCFITSGLLIIENANVTISRYILLDSPLIFFIAAAVYSYKRFENSVPFTFTWYKSLIACGIALGLSLSSKWVGLFTISWVGVCCLLQLWFIIGDLSVRPKTILSHFAIRGAVLLGIPLALYITFFYIHFNLLPNEGDGAAFMSSAFRTTLNGNTIPRDIEAHVGLGSIVTIRHVETQAGYLHSHNHFYPAGSKQQQITLYPHLDSNNKWVIEHYNRTTTEEFEPLHDGMKIRLKHLNTGKRLHSHDEKPPVSERDWQKEVSCYGYEGFAGDANDDWIVEVIQKSTKDIPSKYYVKALTTVFRLKHAMSGNYLFAASAKLPSWGFEQQEVTAAGSGSRPLTFFHIETNENYRVPSNHSLIVNYAEPSFLEKFVEVHKRMWKINAGLTDHHPWQSSPHEWPLLLRGINYWVKDSKHVYFFGNPAIWWASSLSLLTFAVYVTVQIVRWQAAKVVVDEKHVFNFNYQVLTYFLGWFLHYFPFFIMGRQLFLHHYLPALYFGILTTAHFLDIALSYFATHSTGVKYVVFGIFGAYMAISTYFYINYSPLIYGQKWTKSRCEAAKLVGTWDFDCNSYPNNLSEYNFNTQTKTSKADALPNDNIEPNEPKETPLEVVKRAISEESSSQKAPEANSEKNNEEEPLAPPEADPETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9V6</accession>
    <name>G3B9V6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_125387</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9V6"/>
    <dbReference type="STRING" id="590646.G3B9V6"/>
    <dbReference type="GeneID" id="18249101"/>
    <dbReference type="KEGG" id="cten:18249101"/>
    <dbReference type="eggNOG" id="KOG2280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008909_1_0_1"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 N-terminal" evidence="3">
        <location>
            <begin position="268"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 N-terminal" evidence="3">
        <location>
            <begin position="375"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="2">
        <location>
            <begin position="592"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="2">
        <location>
            <begin position="702"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="957" mass="109236" checksum="7F7A08A2007442C5" modified="2011-11-16" version="1">MTSNPSLSWQKIQDVYYSLVPCYETLNWSIGNLYGDHKVKISSHSTSVALSSKYTSHPSVIDIYTISGNNLWSVVYNSTTEDHIVDYEFYNEDLYVVLSNQKFRHYKDLKGSFDEYVFTKDLITLDNFGESDVFLNNVNAEEIQGNSNGKTGGKDHEGTGKLNKHVITNLENNEPEEVFQIFDTYIWGSFLVLRLTNRFIITNLADNHRNYEILIPVTSGPQLHDMALIELTDDGFSAVICYGSTALTLKVDLKSSSYELVDHELTDGPFTKVTVSPNGHLVALLNEQVSTIFVISSSFTQVLLEYDTSNDSSSPYQIEWCANDAIVLSLRDEIKVVGPNQASISFFYDFIDEDDLDFDAVLKGTGDDELSFTIAHLKSEPDGLKILTTKKVEFLSRVSESSRNLYQIGSSHPGSILLDCIDKLTQQSSKADTNISLLKSDVSLINAMDSCLDVALDEFNPQWQKKLLSAVTFGKAYVDGYYNSEKYLKVINTIKVLNQLKSADISLFLTSKEADILGWDKIIGMLLNRDQYLLALKVISLLDLQYLRDKIYVHWCCYKIKKEIDVEDSELYKIIAKKLVSARDDASKKNYVSVVEISEIAFEEGRLDLCNYLINLEPTIVKKVEQYLKFEKLEIALIKAFESAEYDLVKVLLMHLHSTLSVSQFFKILHQNESHSITDPISEDIDTSNQILVVDGNLVESFWVQSIGKHHREVMEKYYKQEDMKVELSIERLKYFLKQNESPPDISTGLLTYYEDYKMKLLKLSGSSGDRQNYKFHQSELDVLELQKKLSDTYQTDFFSTKSLSQILVKLINMHQLKQGHKIVKDFKMSLSKFWYLILETYCSTSNFDRLHQFILSSSNDKTNLKSPIGFQIIVETCLAYKGPPNYISMYINQCSDIHYLDKCHLFISNNDLVSAANEAYKYKDIEFLNSLLDRANKHANDSVVQSIKGLITRLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9Z9</accession>
    <name>G3B9Z9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_123932</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B9Z9"/>
    <dbReference type="GeneID" id="18248993"/>
    <dbReference type="KEGG" id="cten:18248993"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_5_2_1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000035">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1055"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1086"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1175"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1202"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1023"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="784"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="14">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="847"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="848"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="971"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="977"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="997"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1000"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1001"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1001"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV61365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1427" mass="162093" checksum="C86E07B478528D28" modified="2011-11-16" version="1">MPQYMKEIYFKTPRYVFVNQELPSEMKDAFGKPVLTYARNKIRTTKYTVLSFLPKNLLFQFRNAANSYFLLLVILGIFQIFGVPNPGLAAVPLIVIVCITAIRDAFEDYRRGSSDYDLNNSPIHLLHGVHNTNVLKDDISGWRKFKKANTKVVRSIMKVLKKGAIMTFTNKKTKQEFIRKEQQIYNTDLRRVSTIISDTSIAENGYRASFQSAGRRSHQFSVKPKEIAHSLINPTLIQENYGKDGDFKFKNRCWKDVSVGDFIRVRANEEVPADMVLVSTSDIEGNCFIETKNLDGETNLKVKKCVEAGGANHLKHSNDLANTKFWLECDPPNANLYGFKGTIHYEDYDKEGNLIHPDEKEPVNNDNVMLRGSTLRNTKWVIGLVVYTGEESKIMLNSGITPTKASRISRELNLSVFINFALVFIMCFVSAIVNGIFYNKSDTSRVFYEFQAYGSTAAINGVICFFVVLIVYQSLVPISLYISVEIVKTCQAFFIFSDIKMYYDKLDYPCIPKSWNISDDLGQIEYVFSDKTGTLTQNVMEFKKSTINGVSYGLAYSEAKQGLDRRNGVDIIQQSEMWKNKIAADKAVMVDDLEKFSENDQFREESLTFISSQYVKDTLVPETLDKTQKAANETFMLALALCHTVMTEVNAFDESLRDYKAESPDEAALVAVARDVGITFKERQRNLLTVEVYGEEQKYELLETIQFTSARKRMSCFVRTPEGKILLLCKGADNVIFQRLSKSGNSSNVISKTALHLEEYAKEGLRTLCIAQKEVDSYSFNQWLKRYKEAKASIEDDRDDILEELSEEIENNLVLLGGTAIEDRLQQGVPDSISLLSEAGIKLWVLTGDRIETAINIGFSCNLLTTSMKLLVVKPDDDDSTNADPVDELVSKYLQQDLGITDLSNAGVDQLIKTAINDHSTPTNDLALIIDGAALALVFGNEIDGLTEKQLYLKKKFLYLGKQCKSVICCRVSPAQKAQVVKMVKNDLQVMTLAIGDGANDVAMIQTADVGVGIAGEEGRQAVMSADYAIGQFRFLTRLLLVHGRWSYKRLAEMIPCFFYKNVVFTFTCFWYGVYNNFDGSYYYEYTFLMFYNLAFTSLPIIFLAVFDQDVSDTVSLLVPPLYRSGILRKDWTQTKFTWYMFDGLYQSVIAFFFVILTFRLSFQNPQGLAVDHRFWQGVICCAICVTSCDIYVLLKQYRWDYISLIIYSLSILVVFFWVGVWSATTNSQEFYGAGAQTLGTLSLWCVYFVSVLICLLPRFTYDLLMTNFRPKDIDIIREKVRQGAYDDYPQGYDPTNMEDVERHRLLKELYKIDPDALAKFEQELQSVHSSASSEPKNDHNPFAKTFKSIRRKTTINRSRGNTLAKEMNSSFHKPIDLDKLRKQMINNGELGGGGLTRISTTHELPGLTQAETLISYHTRTSINFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAB8</accession>
    <name>G3BAB8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxS/MPP-like metallohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114883</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAB8"/>
    <dbReference type="STRING" id="590646.G3BAB8"/>
    <dbReference type="eggNOG" id="KOG0960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF126">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="3">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="4">
        <location>
            <begin position="182"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="446" mass="48319" checksum="3342FEB2D1DCD94C" modified="2011-11-16" version="1">MIRGSTFKSGMKSVAAAKRAIATATTPTKYATLSNGVTIATETNPHAKVSTIGLWFGAGSRSEHSYSNGISALTVSTLASTLEDGVLLTSQSTKETNAIIAQTTNDNVLEAAKLISKIGSNPSEYLEKADLALSKSQLIAQAAQLEATPDKMVLEHLNASAFQGYSLALPTLGTSESISGLQLQDSERLLERHLVGSNVVVAASGNFDHNQLVEAVEAALSIKQGHKPAVKPASFLGSEVKMRDDTMPKAYVALAAQGEGVSSPAYYVAQVASKIFNDFDHHSAFAKFQSPKLASQVQEYHIVDKYTHFSTSYSDTGLWGFNAEISNIYQIDDFVHFTLKQWNRLSISITDAEVERAKQQTKTALLAGLNSTEAIASDIAKKVLLLGYRTSIRESLEKIDAITTKDVRAWAQAALWDKDIVISGTGQIEGLMDYNRWRNGMAMMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAC0</accession>
    <name>G3BAC0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Guanine nucleotide binding protein, alpha subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_108516</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAC0"/>
    <dbReference type="STRING" id="590646.G3BAC0"/>
    <dbReference type="GeneID" id="18246035"/>
    <dbReference type="KEGG" id="cten:18246035"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000015">
        <property type="entry name" value="G protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000563">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="260"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="285"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="354"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="49907" checksum="AD840383B99E0664" modified="2011-11-16" version="1">MGCTASVPDPDDQDPFLMDKRVNAAINQSLQSNRKNSKNQVSLLLLGAGESGKSTVLKQLRLLHKGGFSDQERIQYGHVIWVDAIQSMKILIVQARALGIRLDCDDWSGSLYQYKRMVLKANALQQIDTSIAGGNNFLNEYVLKYSEVRRAKRRQNSTGIANNSFWDDNNSPRTGNNDRIVEEEVEAADAEVNGINGTTEKYSRSQIAEAIDMLWKYDSGIQQCFHRSNEFQLESNAAYYFEKIYEFAKPNYLFTNSDILKGRIKTTGITETNFHINSFKFKVLDAGGQRSERKKWIHCFDNITAILFVVAISEYDQTLFEDERVNRMHETLVLFDSLCNSRWFLNTAFILFLNKIDLFETKFSPQSLHKYFNDFTGNTVEDGISYFEKKFLAINKTNKPIYVHRTCATDSTSMKFVLSAVTDMIIEDNLRKSGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAP1</accession>
    <name>G3BAP1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_107439</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688239.1">
        <property type="nucleotide sequence ID" value="XM_006688176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAP1"/>
    <dbReference type="STRING" id="590646.G3BAP1"/>
    <dbReference type="GeneID" id="18245952"/>
    <dbReference type="KEGG" id="cten:18245952"/>
    <dbReference type="eggNOG" id="KOG1986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008658_0_0_1"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000041">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="8">
        <location>
            <begin position="117"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="8">
        <location>
            <begin position="335"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="10">
        <location>
            <begin position="417"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="7">
        <location>
            <begin position="659"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="792" mass="89393" checksum="5456D57F76212BCC" modified="2011-11-16" version="1">MSDTSYFDTREEVDGVRVTWNSLPRTKLQHERNVTPMAAMYTPLNNKHGDPIPSSHQIVNCRQCQSFIHPYVNRNEETWVCTYCGFSNRLVVDEAGNFPVGLAASTVEYHTSKFNNLPPIFIYVVDTCFETEDRDAYESLKQSLVVSLSLLPENSLVGLVSFGKNVAIHNLSSANAMCHSFNGAKEYTLEQFRQSLGLLDTSLKRNHHPDELFGSIGKQFLQPVNLVEYQLTNVIETLTTNTFPRAERKERPYRATGCAINVASLLLTSLLGTYGSNGGQLLCFIGGACTYGPGAIVGNQLKEPLRSHHDIETSRQSTLAKNMKLPQQSTNFTVDYSLVLKAKTFYKTITQYLVKLGVSCSYFIGSYDQVGLYEMDEVCRKTGGVVIMSDSFNTSIFKQSFLKFFRKEPDSEYLEFGLNATLEVKVELDLKVEGLIGNAVGLPLNQKNGALVSQKPIKGEGNTNCWKLCHVDPQSTFAIFFEKLDTRYNANSTTIQFITHYQHSSGEFIIRVTTFPIAIIHDSDAGRLELGFDQYAAAACLARDYTYRLETENVSHADVVKDIDKISVDFCTRFAQYHKGTVSSFMLSNRYSFLPHVVYHLRRSPFINVFNNSPDETSFIRHVLMHEDTNNILIMVQPTLLSYDIDTFGSVDENGVANTDPQPVLLDSMSLSKSKILLLDTFFHILIYHGGQVAEWRKLGYHNQEGYEHFKEFLEAPKKEAMEILMDRFPLPRFIDCDEGGSQARFLMAKLNPSSSYSSNPNIFYGNQLDVLTDDLSMQSFMDHIQRIVTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAP2</accession>
    <name>G3BAP2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_107381</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAP2"/>
    <dbReference type="STRING" id="590646.G3BAP2"/>
    <dbReference type="GeneID" id="18245950"/>
    <dbReference type="KEGG" id="cten:18245950"/>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051385_2_1_1"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="221" mass="25996" checksum="C577D9C580C9C301" modified="2011-11-16" version="1">MSQNRRIKNVSISVPILYGNNAVKLADEKRTALTPPDHTHEWTVFLKPVLDDIDLTPLIKRVTFKLHETYDNPVRSIEHPPYQVTETGWGEFEIIIKIHFHTGSELGINEKNFQIFHGLKLHPFNPKIPPKENGEINSVLYDELVFQEPTESTFEILTRKPANYLPQKISDEDKKDQEFCRQDEQDELARLDAQIYRIKHEIENQRNRYKELEQEKIALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAY8</accession>
    <name>G3BAY8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114954</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAY8"/>
    <dbReference type="STRING" id="590646.G3BAY8"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="275" mass="31794" checksum="BF8F5E7137C3A0BD" modified="2011-11-16" version="1">MSCPTSCRTYGLPHSYVAFLCRILMSHSYVAPMSLPCRTSLSLSCPSPCRSHSTLAHLLSDTTTMNVFRFLGDMSHLAAAFILLFSIEKNRSIKGLSIKTQALYAVVFVTRYLDVFKFSSFYLTIMKLFFIGSSLYTVYIMATKYRKTIQEDFDQFPVRYLVLGSVFMALAFPRKYRAGEMIWTFSLWLESVAILPQLFILQRTGEAENITTHYIFALGLYRALYIPNWFYRYFAENRLDTTSILSGLVQAVIYSDFFYIYYTKVMHGKRFSLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB33</accession>
    <name>G3BB33_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_131548</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB33"/>
    <dbReference type="STRING" id="590646.G3BB33"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008136_1_1_1"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="447"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="922" mass="102966" checksum="525FFC88313F72C7" modified="2011-11-16" version="1">MTTPSAVAWTPDLQAVDQLKLIIGSTFSSNNVERNAANESLVLAKSQPQIENYLLYILVMDESAKSDVRAASGINLKNIISRSSSGSPETHQFILDNIAHGLTSHDNMVRNTTGNVITALFSKYGLAGWPQVLPSLVNLAKSADPTAADTKIADAAMSALAKICEDSHYKLNVELEGERPLDYLMASFIELLESCSNRVKALSIECIDYFIPHRSQSVLVVLDVFLQKLFQLAHNSNKDVKKSVCKAFASVLEARGDKLLPHVDGVITYCLHLMEDEDEEVALEACEFLLALSTSPEVEQNPEIFRGRLHDVLPALLEKMVYSEEEIFFMNLVDEKDDATVADNEEDIRPQAAKSKESHKAASKSGNKNNSYDDNDDSDDEDFEDDSDDDSELDQWSIRKCSAACLDVLSLNLQSEVLEVTLPILQERIVSSHKSCMELSRDKLPTLVPFLVDRLQDDEPRVRQITCWTISRFSSWVAEEAHEGGHYSSYFDPTFTSILKCALDRKKVVQEAACSALSSFIEETDPTLIEMYLVPLLQHFAKCFSTYQRKNLIILYDCVQTFVEAMGHERLAAKQEYVEVLLPPLLHKWELLDDNDTALWPLLECMASIAATLGELFAPYAMPVYGRAVNILTNTIHTDLQSQTDPSIDLPEKDFMVTSLDLIDGLIQGFGSHSLELIQSNRINLMELVLQCFEDSTDDVRQSAYALLGDLAIFVLDATVVPYLNQIMVCIGNEINTRNFNSYPVYNNAIWSLGEICMRLSYEQLKPYLANLVSLLIPVLNSMDTPQTVLENAAICLGRMGLHGGAEVVGPRLPEFIVQWCAHMLYLMDDSEKETGFKGMLNTIASNPDQGFGGLSTLQGKKNLSTFISTVANYFEPPEDLKHSFSQLLQSYSGLLGENFNTQVLNHLDQESRRSLYEMYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB40</accession>
    <name>G3BB40_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_131552</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB40"/>
    <dbReference type="STRING" id="590646.G3BB40"/>
    <dbReference type="GeneID" id="18249537"/>
    <dbReference type="KEGG" id="cten:18249537"/>
    <dbReference type="eggNOG" id="KOG2815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073662_0_0_1"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="35227" checksum="766A7C5CDF3188D5" modified="2011-11-16" version="1">MAKEHDQSTECVKDTANWPFRPALAAKQMVPPNATRSKLKSLKKKEKRLKRQVTRDINNLKQHHLKHVKFQVDPVLGNPSNGFIQRVREDISDQTNLAGGYTREEVEKLFYGVEKVTLSKIKGSNVLLESAVEAEQHKKTAVLTMLNMRNTNAKDKRLLAINRAKREFARVEGDTGSPEVQAAIMTVKIHLGMDHVKQFHKDKVHLQNVRELVQQRQSILRYLKKVRPEDYYYCLEKLGLTDDVITREFNMGRQYLQDYKVWGDKQLVKLSDKQKRKEQKFTELQKKVVSYNQLARANFDALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB77</accession>
    <name>G3BB77_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_94398</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB77"/>
    <dbReference type="STRING" id="590646.G3BB77"/>
    <dbReference type="GeneID" id="18250392"/>
    <dbReference type="KEGG" id="cten:18250392"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018359_0_0_1"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="407"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="325"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="526" mass="55045" checksum="476199FC384FA987" modified="2011-11-16" version="1">MSDHYNIQLDTNAPSQMIHPHPQTVLPPTSQHLAPLLVPPSGVNTLGDVQVQVPPTSVGGSSSGPNSGGPASAPSALPSVVEAPTSSSAFVLKIHNIPHDVSVREATLVFALVIDHIVKIDLNANEHVISAYFNNFNTCLTTYKLLHQKCIFGNDVPVSVEMEESLGLDFNQLSLRNGGSTGASASGTVRSRFSFSDPFEFDKDLESQTSSQPQTPINNLNFDWSQSNSASLASKNTSSSRRTSSAFFQSNFSNNLLNNSFLSQPLGQPIVGQSLMQPMGQIPAPQSVSQTSPDAPSASVNVQSGTALGASANSGQAQPPSQNGSVSSTAANTAPTPPGTTASAPASTQSAPATAVSPSASAAQPSAAITSPIQQVAGGARKDVPDLSLLARVPPPANPADQNPPCNTLYVGNLPPDATEQELRALFSPQKGFRRLSFRTKANASGSGSNNHGPMCFVEFEDVAHATRALAELYGRILPRPSSSNGKGGIRLSFSKNPLGVRGSQRRSSSNQVNNGTFNYNYHMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB94</accession>
    <name>G3BB94_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114990</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB94"/>
    <dbReference type="STRING" id="590646.G3BB94"/>
    <dbReference type="GeneID" id="18247660"/>
    <dbReference type="KEGG" id="cten:18247660"/>
    <dbReference type="eggNOG" id="KOG3180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_0_0_1"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
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        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
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    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
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    </dbReference>
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        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="255" mass="27967" checksum="A05CCCE28ACDAF43" modified="2011-11-16" version="1">MSTKLRVLVPVKRVIDFAIKPIINKTQTGVETKGVKFSMNPFCDIALEESIRLKEKNKDLVELIHAVSIGPSKAQDVLRTALAKGADSTTLVDVGDEEVEPLTVAKMLKQMVERQNANLVILGKQAIDDDSNQTGQILAGLLNWPQATNASKVEVDGDFVSVTREVDGGANTLKAKLPMIITTDLRLNEPRYASLPNIMKAKKKPLEKLKPQDLGIELVKRLETVKVEAPAERPKGIMVGSVDELVSKLKERKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBA2</accession>
    <name>G3BBA2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114997</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBA2"/>
    <dbReference type="STRING" id="590646.G3BBA2"/>
    <dbReference type="eggNOG" id="ENOG502SE1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056577_0_0_1"/>
    <dbReference type="OrthoDB" id="4063176at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="231" mass="26038" checksum="8D6544396AC46E32" modified="2011-11-16" version="1">MADPKIHSPKKRTPSKSETDKRRTPSFSNTSSPWFRRNSFLSPAMIHSENISVYECPNYYSDSSTYNIISLKECQGFIFNQDLFASPYQQQRTLISERKLRAMSHSFHKSRSNSSSHSRSNSMSGPTGTQRRHTSYHGHKPVFATAIIDNSAIEDDDEDVSNSSVREAFNQFENTTVDIELDTQDEDIDGLAVEDADDVDVLVGEGTGGMYKVHVTEIVVNDSDDIFPVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBE1</accession>
    <name>G3BBE1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_125766</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBE1"/>
    <dbReference type="STRING" id="590646.G3BBE1"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031900_2_1_1"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000016">
        <property type="entry name" value="Inhibitor of growth protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="280"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="172"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV62167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="336" mass="37454" checksum="995313F60A2C4676" modified="2011-11-16" version="1">MTLDLPPRQKSQRLRSRSRHNAQQLRLQSYLNKSKTISSINELLPGLNDITDAFEALPSDIIKYFTLLKEIDAKCIGTVPLITSNISQYIDGLHQSTSPSATTKAAHLSLIRDHISDIIPCLEEKMHVTSIATDVVEKHLFRINNDFKLIINNNEIPESIRIGPLNHPALIMDATANDNPNRSAQSSRSETRREALAAKKQSKDDDYSYGVVVPRREGTPSGDGKKKRSRKEGPTATVSAAVVSSNPAYAATAMGSPSRSITPQPKKKIKVTREESANEPTYCYCNQVSFGEMVGCDGDDCKREWFHLPCIGFKHPPKGKWYCDDCVSKQKKMKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBH0</accession>
    <name>G3BBH0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIRM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115655</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688360.1">
        <property type="nucleotide sequence ID" value="XM_006688297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBH0"/>
    <dbReference type="STRING" id="590646.G3BBH0"/>
    <dbReference type="GeneID" id="18247953"/>
    <dbReference type="KEGG" id="cten:18247953"/>
    <dbReference type="eggNOG" id="ENOG502R6VN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042442_0_1_1"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="230"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="327" mass="37333" checksum="136471855922DCB1" modified="2011-11-16" version="1">MSTIYHPSAKSISSRLDEGCLTPQNPQLEAKSQRIAIATSSSSHNKPNQLDILSPPLSPYQRTDSVGPAPVAGDQALIRSYLPNKPFSLENYNNYDLKVNPWTNLNNDYRARQFAFLKKYSIIKKKETDRYLREKAGAKKRKYNTNGFMGHLSDSNSNSDNGSNKVRTRRIIKESNNELTDKLPTRSSSPASSPKKRKPNIQQQQQSFIDENIPDYSPELSTLPNNAKCMKIDWKGQPMDLSGDPNTHKLHPAEVTLASVLRLPCNVYLDSKRRLFYEKVNRLRAGMQFRRTDAQKACRIDVNKASRLFAAFEKVGWLDDHHFDRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBU3</accession>
    <name>G3BBU3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_111402</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBU3"/>
    <dbReference type="STRING" id="590646.G3BBU3"/>
    <dbReference type="GeneID" id="18246274"/>
    <dbReference type="KEGG" id="cten:18246274"/>
    <dbReference type="eggNOG" id="KOG2794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_1_1"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV60079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="339" mass="37353" checksum="E5A070543F678245" modified="2011-11-16" version="1">MVHTAEYLAKSGTSISSLLQGGYNHPLSRDWHNQRMLTKDMFIFPLFVSDEPDEETPMESLPKMKRFGTNKIVAYVDTLVKKGLRSVILFGVVKQEAKDEVGTAADDPNGPVIVTIKLLKKHFPDLYVMCDVCLCEYTSHGHCGVLLEDGTLNREPSVLRIGKVAVNYAKAGANCVAPSDMIDGRVKDIKLGLVEANVAHKCMLMSYSAKFAGSLYGPFRDTVGSAPSHGDRRSYQLPVGGSGLARRALRRDMEEGTDAVIVKPSTFYMDVLKDAAEICKDYPVCAYHVSGEYAMLHAAAEKGVVDLRAIAFESHYGLVRAGARMIISYFTPDFLDWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC09</accession>
    <name>G3BC09_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rrp15p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116821</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC09"/>
    <dbReference type="STRING" id="590646.G3BC09"/>
    <dbReference type="GeneID" id="18248460"/>
    <dbReference type="KEGG" id="cten:18248460"/>
    <dbReference type="eggNOG" id="KOG2974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058264_0_0_1"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="238" mass="26380" checksum="F0674A7B01D9BDDE" modified="2011-11-16" version="1">MSAKAVKKQKTSTGKAKPVAVVHNESNEESISESSQSASEDDESVSETHDSSAADDSDIDDEHEIDAASDSNDDSDEDSDDDIPKLKKKKNTDDGSASFANAFTNIIGSKLKAHSRAAPIMTRNKVVLKKLETDKLEHKAKRALLSEKKQAFDKHRVKNLLPTGEEENIRQILESEKKLKKVAQKGVVRLFNAIMSTQVRTNEAISKEKVGQVKKEELFNEMSKEKFLDLVQSTAHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC43</accession>
    <name>G3BC43_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_128397</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC43"/>
    <dbReference type="STRING" id="590646.G3BC43"/>
    <dbReference type="eggNOG" id="KOG1768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129451_1_0_1"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="118" mass="13500" checksum="02333F3EC3A0FDBA" modified="2011-11-16" version="1">MAKKRASNGRNKKGRGHVKPVRCLNCAACVPKDKAIKRVTIRNMVEAAAIRDLSEASVYQEYALPKLYNKLHYCVSCAIHARIVRVRSRTDRRIRTPPQRKRFNTDRKVSPQDAAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC52</accession>
    <name>G3BC52_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF962-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116853</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690003.1">
        <property type="nucleotide sequence ID" value="XM_006689940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC52"/>
    <dbReference type="GeneID" id="18248473"/>
    <dbReference type="KEGG" id="cten:18248473"/>
    <dbReference type="eggNOG" id="KOG3292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081702_1_1_1"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="191" mass="21916" checksum="C02CC68FD9CEC7F8" modified="2011-11-16" version="1">MTGLLDLKEHLVFYRSYHTNPKNVNIHLICIPIILTSAIAILATFALSNPYLNLGAFLISSFGTFYVLLDWKVGIPTACVYGTFAYAFTNYYHFVAESPLSYFTQPDIFKFAVFVHVVAWLAQFYGHKFHEQRAPALLDNLLGALVLAPYFVSFEVAFWLGFRQDIKEYMDKGAAQKRLEFMRQQSTKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCF4</accession>
    <name>G3BCF4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116888</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690034.1">
        <property type="nucleotide sequence ID" value="XM_006689971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCF4"/>
    <dbReference type="STRING" id="590646.G3BCF4"/>
    <dbReference type="GeneID" id="18248491"/>
    <dbReference type="KEGG" id="cten:18248491"/>
    <dbReference type="eggNOG" id="ENOG502S2RJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091402_0_0_1"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="204" mass="21337" checksum="A1D2BBFA03D3F55B" modified="2011-11-16" version="1">MSKQPPNQPQVPDGWLAKFDDKYKTWFYVDLNTKKSQWEAPSGTTFPSEATDVPPPSYSPNASKVQGTGSAPTRDQSGYAQQGNGGYAQQGYGGYPQQGYGAQQGYGAQQAYGAQQGYGAQQGYGGYPPQQGYYQQPVQQGRSSRMGGMGGMGGMALGMGGGLLGGMLIGDMISDSQNQSYAEGYNDGQDGGDFGGGDFGGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCG7</accession>
    <name>G3BCG7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_128506</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCG7"/>
    <dbReference type="STRING" id="590646.G3BCG7"/>
    <dbReference type="MEROPS" id="G05.001"/>
    <dbReference type="eggNOG" id="KOG4130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049909_1_0_1"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="132"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="269" mass="29530" checksum="A4EE6CC189FFC799" modified="2011-11-16" version="1">MNGIASVAASVVIAALYVIVIHAWTPTTLQGSSRDDAALITHRLRRVSGLCVVLLAVVPSILVYEDPSTSLTGVYELMGVLIPRKDVVDTFSAPLRCLSASLVLFSGPIFAYIVETPTKYWSHDFQQSFYSLQGFRNHVFAPITEELVYRSIVFVVLSKQFPTTTIILYSPLLFGLAHAHHGYDLVVHQGVSVAMAVSSVTFQTLYTSLFGVLAGYVFERYNSMWCAAILHAVCNVMGIPPITVHGSVVAKFVYYLLLPLGVYGFINMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCQ9</accession>
    <name>G3BCQ9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116914</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690497.1">
        <property type="nucleotide sequence ID" value="XM_006690434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCQ9"/>
    <dbReference type="STRING" id="590646.G3BCQ9"/>
    <dbReference type="GeneID" id="18248505"/>
    <dbReference type="KEGG" id="cten:18248505"/>
    <dbReference type="eggNOG" id="ENOG502S1MK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_897154_0_0_1"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="304" mass="35960" checksum="B9996C0E96EC4F4B" modified="2011-11-16" version="1">MDSFEANTQFTQLLRELNPTVQSLRKAAHFAIKNWENEDYLFTSIMSILQDPKIEVNTKSTIFQFIDILVNESHTISSQPRSNYSYPYISSVKNSLPSILLDVLPASNNYNLHSVFNSLRNISRVLKIDCQKFEDDFSSFSPDILDDNDRQNIDLNVPYPNITLENSDSANDPVTRTWELLSQKRKQSYYERLRLLKHQKPVEQEVKESEMFNLRPKDKYGPNELSRKQILSRMEDDRETHKRSKENLWVVNRPKEVPYVTEHEFQQYYWNRYDSLSDKDEKALLETLDDFNTVVMASYKDNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCU8</accession>
    <name>G3BCU8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116265</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCU8"/>
    <dbReference type="GeneID" id="18248221"/>
    <dbReference type="KEGG" id="cten:18248221"/>
    <dbReference type="eggNOG" id="ENOG502RPUV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_545108_0_0_1"/>
    <dbReference type="OrthoDB" id="4077683at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="500" mass="57488" checksum="7E6194B0C8D17F7D" modified="2011-11-16" version="1">MSTNTNPWSVSRCKRVVRPLVARIHSLTDTVVKNPSLLHISSTPTSNTGINILAGMVKPATAAARLQALQPFVSPELYSYLLDIFHIFKSIVTSLETGSNPAPFIDPLGSKCSYEIGKAMVLSTRASYYKLNNSILFDPKSLPESTRKYHHSLSSDIDPWLQLQPSSIFEPLRLDILRGYLLHVIVFNSPRLLYLLVPTLIHWLYEESIVMGSSRLKSMSNKLFYEFWHFDSANYYDNIGDKAVKQLSRIDGDSNDLFWWLNSIGYWDNMISSIGMTSSQIGHNQYEVLILDTLILNNKLMDGGDDSEVYALLRRNSTHLQVNNILITMLTRLIKQSSYNPNQLNETYYGFLRLIQSWLAFGSETPGLFNSLQTGNDAMFKGVISFSRYLHKSLSKSDDLTKLLILLFHYYTNRQPGIQLIGLDAHHRVLLKTLRMIQMEELKKFIPLKYSNYEISSFIYWLLDNKLGKFASAVFYDYYGQFSKYYDDDLRHIHRLIKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD21</accession>
    <name>G3BD21_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AMPKBI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116950</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD21"/>
    <dbReference type="STRING" id="590646.G3BD21"/>
    <dbReference type="GeneID" id="18248517"/>
    <dbReference type="KEGG" id="cten:18248517"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033562_1_0_1"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140767">
        <property type="term" value="F:enzyme-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="283"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="398" mass="44229" checksum="EBD44755285013FD" modified="2011-11-16" version="1">MSNSSAPGESKDISMVDVSNALPDVSSGDNQSQDTFTAPPIRRKSTLILTDEDHMKLEEPLTNTSNTDADTMHIDRSQTNLNQGPAQSSPPPASSQSQQSPPPPPAQATAEADLTVTVPVEIKWSQGGEKVYVTGSFTGWRKMIGLARQPDNNFLITLGLPVGTHRFRFVIDNELRFSDYLPTATDQMGNFVNYVEVTPENVQSYLDQQAHADLSDEDKSELESQLTDEETSVGDVQPPTSLSRKSSISRSATRSDSMWGLTNDDDDMGNGYSRYHDEDIDANLHKTYQFINDIPPIFVDPKVMEQYYMAIEKQSKAQNGQQAWLHPPQLPPHLENVILNNFNSMDRDNNSGALPIPNHVVLNHLATTSIKHNTLSVASIVRYKRKYVTQVLYAPLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD82</accession>
    <name>G3BD82_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116322</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689478.1">
        <property type="nucleotide sequence ID" value="XM_006689415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD82"/>
    <dbReference type="GeneID" id="18248248"/>
    <dbReference type="KEGG" id="cten:18248248"/>
    <dbReference type="HOGENOM" id="CLU_2558084_0_0_1"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="82" mass="9201" checksum="120ECE7DBF534A93" modified="2011-11-16" version="1">MVYQFLRRLSNPNVSVTPTQLPESQQQTVSKPVSANEGQNSVKSPIIQSLPMNKSLFNVQQEDLKKRNQKFLSSSDNLIVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD83</accession>
    <name>G3BD83_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tubulin-folding cofactor D ARM repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689477.1">
        <property type="nucleotide sequence ID" value="XM_006689414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD83"/>
    <dbReference type="STRING" id="590646.G3BD83"/>
    <dbReference type="GeneID" id="18249999"/>
    <dbReference type="KEGG" id="cten:18249999"/>
    <dbReference type="eggNOG" id="KOG1943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011301_0_0_1"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="1">
        <location>
            <begin position="379"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1053" mass="121947" checksum="ABF50FC718E765E9" modified="2011-11-16" version="1">MELDEYESDDLLNALSRQSDQLILQITNKVQRLPLDHSHIVVDSIVNLINEFEMGPNLLDSVLTPIIESLIQFYINEWDKTNFPNEMTRAIGVVVYNLAKVRGFKPISNFFPSDVYMVIKILAMLQRNDLDENETFFNLLWLTNLVLVPFSFEKHMINNFFDISLFHLKKHSNGSKNQQCSSILMSRFLSRPDLIQLGYLDEYLCGLFENWDETIESEKLGHFMVINKLLKICPKSSILTYTNKIYDQIIQLELMNLKIGRMNKLNLSFIIKILCKLAEDFAAENQYSLIEKIMDNLINDVLKFFNESLETNLRYKLSKSLSGISKSLVRVVNYHEQILIYLIQQLDLSIDISEPSDYSSISMSTFLDVDIDFDQISIATYHTILLYLGYMALNRILPLHIYPAALSIVHKTLFTHQRRYSNNVGNQLKDSSCFILWSIMKSLSTSDYEQLESTNPTMFMQLFIDLIEVSIFDKDLIIRRCGVSVLQEVVGRIGNRLIKTEDRMLKGQQTILFVEIFASNNVSTVSESFKSLDKLLGMGLDKGLLVEMIIRNILKNDDDFEYQKLLSSKLIQFMKTSSEANLPLSISRPVPDYMAISNTFAEMNHSLYLQSELWRNFEDTNEHTKIVDIKDFSDGKAEDFIEFVAYRCNAGCVDDLEHFFEKIVHTKRDTSDRLVKLFTLMSKKRIGISDNVFKTVAHYLPASFTKSIFYLETLTQPQIQRLLLIVHSAHLDYEIRFNLIVCLHKVYSSSKLINANQLNHLIELLNDYTTTEQGDVGSKIREALLNFIQDFLPAFIASASTLTESLWRISGEPIGKLRTKAFSILLKLNGVDFSLETMSEYSYYKHLFQFYDSNASTQEEVTQFWKGIILSIGGLTGETTNIKASFKQFILYLDMKDQDGKNSIFKEILSLITKKNIESQKTLKEYMHGLNLMVKMFESNSYVPTEYLSSLYVKAYNLQINCSNLIRIKLSLRVMMWLCIQGQDKKTATISIKRIINVIKTHRVSPIRTYCMELFYEILLERHDPKHEELETLDIDDKQSVDHITKYLLTLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD94</accession>
    <name>G3BD94_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TRP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_95725</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD94"/>
    <dbReference type="STRING" id="590646.G3BD94"/>
    <dbReference type="GeneID" id="18250533"/>
    <dbReference type="KEGG" id="cten:18250533"/>
    <dbReference type="eggNOG" id="ENOG502QSVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010226_0_0_1"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF4">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442899" evidence="9">
        <location>
            <begin position="18"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="726"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="736"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="759" mass="85112" checksum="9ABE7005FD9A6858" modified="2011-11-16" version="1">MLFHMWTLLLWANITLATRSLMATSLVTCSEKSLITPSYFNVTFNPDDLSLRYNIDLTTDISGYVIGHVYVYAYGFLLIEDKIDLCSLGWKQFCPVYPGSLQIDSIQYISKKTAALLPGIAYQVPDIDAIVKVYVVDRDSGETLSCLQSSFSNGKTVSQVGAKWATAVIAGLGLLIAAFLSTFGNSNAASNVSANAVSLFLYFQSVVVVSMQSVDRLPPIASAWAENLAWSMGLIRVKFMQDIFRWYVQSTGGTPTTYFMGTTKQILVQRAYDYLENLHSYVKRGLEYSLHSNSNLIVLRGIKRIGYDSHIEPTSIVATGFTFFVLIGYLLIFILFILKQIVDLLIQTKKLNPNSFNYFRRSFGTIIKGTTLRYIYIGFTQLVILSLWEFTQNDSPAMIVLSVLSLLMVFAVIGWSLYRTFRVGKASIQQFNNPAALLYGDETILNKYGFCYTMFNASKYWFGTVIVAYNLIKGIFISLCQPAAKVSVVVVFVLDLAYTIYLFTQAPYLNKPTNIINYIMAIVITINSFLFMFFSDLFGQPAPVASIMAWVFFILNAAFSLILLLFIIVFSALSVLSKNPDARFAPAKDDRTSFQRMSSIKRNSQYSEEKTAHHSANELMALGVAAQDHTTNWEQEMYKLGNVSAGTAQPSSDKDILTPELGHEKSSEVDFEETEQHNSTESIDEPQSFLGARLKSLSRSLSKKKKTDNNANDGNLTRLSDTLMHEDSFSHPEPTISHQRNQSNYSDFVNNPTDKRNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEM1</accession>
    <name>G3BEM1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">beta-glucosidase</fullName>
            <ecNumber evidence="3 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BGLx</name>
        <name evidence="8" type="ORF">CANTEDRAFT_131830</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 6"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEM1"/>
    <dbReference type="STRING" id="590646.G3BEM1"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="395"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="834" mass="92651" checksum="118F51924A00BFA5" modified="2011-11-16" version="1">MDVEKILTQLTLEEKILLLSGKDNWHTHDISRLKIPKVKCSDGPNGVRGSKGFNGVPAACFPCGTALASTFNKSLLTEAGKLMGLEAKHKSAHIILGPTCNMQRGPLGGRGFESFSEDPYLSGMSSSAVINGIQHEHIAATIKHYVCNDLEHERKASDSILSERNLREIYLEPFRLAVKYSSPRCFMTSYTKVNGDRASQSKKLLNDILRGEWGWNGLIMSDWHGLYTSETALKNGLDLEMPGPTYYRSVNAIKHMVESRELNIQFLDERVRNVLNLVNFTLDSGIIADGPEDTDNDTQETSALLRKLSAESIVLLKNEDKILPLAKYEKIAVIGPNAKTGIFSGGGSAFLRPYHVTTSYDGISSKLSNPPEYTVGCYSFKQLPSLANQLTNPFTGKVGYNMKFFLNPPGKANRRQFDELNLDQAYIFLQDYRHSGLNSDLYYIDIEGDFAPQESAEYSFGCTVLGTALLYVDDKLVVDNKHDQKKGNSFFNSGSTEKRNSIFLKKGKSYRVKVEFGSRPTFSAPDATVVDFGGGGGIAFGCAKVIDPQEEIKHAASISKQVDKVVLCIGLSNEWETEGSDRDNMDLPLLTNQLVEAVLKANPNTVIVNQSGTPVEFPWLDKSKCLVQSWYGGNEAGHAIADVLFGDYNPSGRLSLTFPLTLVDNPTFLNFKTERGRVLYGEDIFMGYRYYEKMKKAVSFPFGHGLSYTSFEYSKLLVEIDEENDELNVCVSVENTGSCDGDEVIQLYTSHKNPKTIKPCQELKGYEKVSIKAGESARVEIHLSLKDSLSFFDEYFGKWSLEAGEYEFRVGKSSGDIRLTQLANITKGKLWLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEM6</accession>
    <name>G3BEM6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Karyopherin alpha in complex with Nup2p N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115963</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEM6"/>
    <dbReference type="STRING" id="590646.G3BEM6"/>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018084_1_0_1"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="35"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV59929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="406" mass="44430" checksum="B969EAFAD485F264" modified="2011-11-16" version="1">MKSSHPDMLQLEAAWALTNIASGNSDQTRVVVEAGAVPLFVELLSSQSVEVKEQAIWALGNVAGDSTSYRDFVLECGAMLPVLDLFNSTKMSLIRTATWTLSNLCRGRNPQPDWSIVSQAIPTLAKLIYSIDTETLIDACWAVSYLSDGTSEAIQAVIDARIPHRLVELLGHESTLVQTPALRSIGNIVTGNDLQTQVVINTGALTALGPLLSSPKETIRKEACWTISNITAGNTEQIQAVIEANLIPPVLRLLVNGDYKTKKEACWAISNASSGALTKPDQIRYLVSQGCIKPLCDLLAVGDAKIIEVTLDSLENILKMGEMDREARGASVNEYALYIEEAGGMDKISECQSNENEKIYEKAYHIIVKYFSEEDDQTDDDMVPQAYGETFGFGVQDQDQTQNFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFE9</accession>
    <name>G3BFE9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_96118</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689886.1">
        <property type="nucleotide sequence ID" value="XM_006689823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFE9"/>
    <dbReference type="GeneID" id="18250580"/>
    <dbReference type="KEGG" id="cten:18250580"/>
    <dbReference type="eggNOG" id="ENOG502RM5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_624226_0_0_1"/>
    <dbReference type="OrthoDB" id="4089586at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="393" mass="43719" checksum="B1DB650DD7A96235" modified="2011-11-16" version="1">MNIQNHYHKRRALDALEEQDADRKQLIRLAVMHVIGLSQRKTGSAPVPSGTSEDLNQKCLNYELSINKLKQEWNTKDKINEATIDKLKQEIAKLKQQLKRPGSSQGSSNLFYNTKHPQLKPQTSLSYSTSPYLSRALDTKSFLSPTLNSLNKTTVRNPLLVSPIQNTERRGKYMTSNTMKQLQVPKRQTKPTRSILETPTKGLYDPPSPNKSPSRMSFVENFDKSDSSNDESGYGTLFNGKVKLSTTSSRKVSNNEGKENILMEEKEGPDANSTSIMGDDSENITVITANSNVDSSNNASEDEEYASANSTVAGASNTSGKRKQSKRLNFAESRTQSLSQGLNLDQDGANSLDYYKEGNFAEGADESPNFKTKASTSTTTTFEKKKRRVFKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFL1</accession>
    <name>G3BFL1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_99582</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFL1"/>
    <dbReference type="STRING" id="590646.G3BFL1"/>
    <dbReference type="GeneID" id="18250869"/>
    <dbReference type="KEGG" id="cten:18250869"/>
    <dbReference type="eggNOG" id="KOG2884">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033293_1_0_1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="259" mass="28591" checksum="FD79C1954AE765F3" modified="2011-11-16" version="1">MVLEATMIAIDNSEYMRNEDYPTSRYEAQLSATEYIFQNKVNSNPENTVGLLAYGGNGPEVLSTLTTDFGKILSGAHETKVHGGSHFSSGIQVAALALKHRQNKVQNQRIIVFVGSPITESEKDLEKLAKKMKKNNIAIDVVNFGEESINTSKLEKFNNAINNHDNSHLVTIPPGPRLLYEIVATSPILMEEGYDMDNGDLGGGMDGFGGGDLIDPNMDPDLALALRLSLEEERARQEREALEQEKAEKPELDKIDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFR8</accession>
    <name>G3BFR8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_111397</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BFR8"/>
    <dbReference type="GeneID" id="18246273"/>
    <dbReference type="KEGG" id="cten:18246273"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1458"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1547"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1586"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1625"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1730"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1787"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="285"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1868" mass="215166" checksum="CB7B96C5F55919C0" modified="2011-11-16" version="1">MSYNDNNQNNYYDPNQPVGHDGYYQQQPYDNVNQQEYYDPNAQYQQPYDMDGYQDSNYQQQPNYQQDPEAFSDFSYGGQTPGTPGYDQYGTQYTPSQMSYGGGPRSSGASTPIYGGNGYDPTQFQMSSNLPYPAWSADPQAPIKIEHIEDIFIDLTNKFGFQRDSMRNMFDYFMTLLDSRSSRMSPAQALLSLHADYIGGDNANYKKWYFACQQDLDDSIGFSNMAMGKVGRKARKASKKSKKARKAVEDHGQDIDAMANELEGDYSLEAAEIRWKAKMNNLTPQERVRDVALYLLLWGEANQVRFTPECLCYIYKTAFDYLQSPQCQQRQEAVPEGDYLNRVVTPIYRFIRSQVYEIYDGRFIKREKDHNKVIGYDDVNQLFWYPEGISRIIFEDGSRLVDVPQEERYLRLGEVEWKNVFFKTYKEIRTWLHFVTNFNRIWIIHVCVYWIYMSFYSPSLYTLHYFQTLNNQPVTSSRWAAAAIAGIIASAIQILATLFEWMFVPREWSGAQHLTRRLVFLILIFIANLAPVVFTFYWAGLAAKSKAALVVSVVGFFIAVVSIVFFAIMPLGGLFTSYMNRRSRKYLSSQTFTASFSKLRGLDMWLSYFLWFLVFLAKYLESYFFLIKSLIDPVRILSTTTMRCHGDIWFTNTLCKHQTKIVLGLMLLTDLLLFFLDTYMWYIICNCVFSIGRSFYLGISILTPWRNIFTRLPKRIYSKILATTEMEIKYKPKVLISQIWNAIVISMYREHLLAIDHVQKLLYHQVPSEVEGKRTLRAPTFFVSQDDNSFDTEFFPVNSEAERRISFFAQSLATPILEPLPVDNMPTFTVFTPHYSEKILLSLREIIREDDQYSRVTLLEYLKQLHPVEWDCFVKDTKILAEETAAYENGDDPEKLSEDGLKSKIDDLPFYCIGFKSAAPEYTLRTRIWASLRSQTLYRTVSGFMNYARAIKLLYRVENPELVQYFGGDPEGLELALERMARRKFRFVVSMQRLAKFKEDEMENAEFLLRAYPDLQIAYLDEEPALNEDEEPRVYSALIDGHCEMLENGRRRPKFRVQLSGNPILGDGKSDNQNHAIIFHRGEYIQLIDANQDNYLEECLKIRSVLAEFEELNVEHVNPYAPSLKNKDKTTEFPVAILGAREYIFSENSGVLGDVAAGKEQTFGTLFARTLAQIGGKLHYGHPDFLNATFMLTRGGVSKAQKGLHLNEDIYAGMNAMLRGGRIKHCEYYQCGKGRDMGFGSILNFTTKIGAGMGEQMLSREYYYLSTQLPLDRFLSFYFGHPGFHINNLFIQFSLQCFLLVLANLNSLAHESIFCSYDRYKPITDILYPIGCYNLSPVVDWIRRYTLSIFIVFFISFIPLTIQELIERGVWKAAQRFARHIISLSPMFEVFVAQIYSTSLFTDLTTGGARYISTGRGFATSRIPFSILYSRFADSSIYMGARSMLIILFGTVSHWQPALLWFWASLSALMFSPFIFNPHQFAWEDYFIDYRDFIRWLSRGNTKWHRNSWIGYIRLSRSRITGFKRKLTGDISEKSAGDASRAHRSNVFFADFIPCVFYTAGLFVAFTFINAQTGVTKNVQDVNSTLRVVICALAPVVIDCGVLAFCLGMACCAGPMLGLCCKKTGAVLAGFAHGVAVVIHLVFFIVMWVLEGFSFAKMLLGLCTMIYIQRCLFKFLTLVCLTREFKNDKSNTAFWTGKWYNTGMGWMAFTQPSREFCAKVIELSEFAGDFVLAHIILFFQFPILLIPMIDRWHSTMLFWLKPSRLIRPPIYSLKQAKLRKRMVRKYCTLYFGILILFIVLIAAPAIASRFVPDDLGKQLNTEGSIANGLFQPRKTDNNDTKKPSKAYASSWSFASYTPSKTTSYTTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFS2</accession>
    <name>G3BFS2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_116792</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFS2"/>
    <dbReference type="STRING" id="590646.G3BFS2"/>
    <dbReference type="GeneID" id="18248444"/>
    <dbReference type="KEGG" id="cten:18248444"/>
    <dbReference type="eggNOG" id="KOG3408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117291_0_0_1"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="164" mass="19134" checksum="BA91C30014226977" modified="2011-11-16" version="1">MGRYSVKRYKTKRRTRDLDLVYDDLSSKESIYRLKNQPVDENLPGLGQYYCIECAKYFETQRMLDHHTKSKKHKRRVKELHQRPYTSLESEAASGVNMLKFMESVDKYKRIEQYKKENKQELEELIAQKNPDLDTILGVNDAAEETDAATEAATAGDNDADMMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWA7</accession>
    <name>G3AWA7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="11">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="primary">PSD2</name>
        <name evidence="14" type="ORF">CANTEDRAFT_117432</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="11">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endosome membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="11"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWA7"/>
    <dbReference type="STRING" id="590646.G3AWA7"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002661_0_0_1"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10 11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023242681" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="11">
        <location>
            <begin position="1"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023242680" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="11">
        <location>
            <begin position="964"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="315"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="877"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="964"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="11">
        <location>
            <position position="964"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="11">
        <location>
            <begin position="963"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="11">
        <location>
            <position position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1080" mass="123782" checksum="A440E12F5567D70D" modified="2011-11-16" version="1">MAIIKRRAPRSSSQSSAATVSPTENLFINIHANRAADLIEESRLDIASRITANRTNPILLANLNGQIKKTKRKLSSNNPSWDQILSLPLKPYDRSSVVTLSVWDKHRGYKNYLGELRIDLASVFGDGDNFTPKTELKWYKLYSNDSQKHFVTGSLLLAFELVVKQKKGLAKRSQTVEDFKAMDLTSVAAPSNKKLELLNDWKKSLIYSDDAKALSVNDQGFYSDSGDVSDISDVSLSEADAASLYSDTHSQRSNELSEPQHNLSPEFDIKEQNHMFSTDDLTTDFDESDAVSLVDNEGGRSDPQTRRTRRFKHRKPKHPERSKFEIKNRKVDGVLFLEVVSCSDLPPVRRLTGMGRFDMDPFVVVTFGKQTFRTSWKRHNLNPIFNERLAFEILKQEKSFEVHFLVLDKDRFSLHDDVASVSIPLKDLTKTATAAPKSMYLRPAAEASGESLELTQEEFTDSELPSNKSITIVENNNLVETMEKRIIRKKLKLKYSDTSRFKTMDLALNLVDDKYKNKYSPKLKVRVRYETYENLRRSFWERLLDQYNLADSQDTNIQEKTYDYIELISLLDTLGCENSDEIVTKFFAKYGRSPWGGDTLQIEQICECLEEHIAADDTNNKLFEIEQCPNCLKKRFINKHDVDIVTHFAICGSKDWSLVDKLLVSSYVTPQLASKRWFTKVLIKLSYGKYQLGSNSANILVQDRMTGIILEEKMGVYVRLGIRLLYKGLDKARTKRIRSLLYKLSVKQGTKFDDPASKHDIPSFVRFHKLDLSECLDEDLSKYATFNEFFYRRLKPGARTIEREDDDRVVISPADCRCVVFDSVVESTKLWIKGRNFTIAKLFNGNFYGLENKDIYRAENCAVAVFRLAPQDYHRFHCPVSGVIKKIKFIEGEYYTVNPMAIRSELDVFGENVRALIAIETETFGTVVMIPVGAMMVGSTILTRQEGEEVKKGEEMGYFKFGGSTVILLFERNKFKFDSDLVENSRQQMETLVRVGQSVGHSPGIEEVRRDHMEFSKLTESTRKNLIRVITGGDLADVKEFRSWEASNLTFDDDLDSMVEYVSDYDEEEEKDEDEEGIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWG2</accession>
    <name>G3AWG2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112252</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWG2"/>
    <dbReference type="HOGENOM" id="CLU_2947990_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="60" mass="6929" checksum="82C911C48CC9FBAE" modified="2011-11-16" version="1" fragment="single">EQLFHLFSPHPSKHGPSSSERLKQKELPDHVYNRCSDDALQWRGTRTSTPKLPNSQSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWS7</accession>
    <name>G3AWS7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_100653</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWS7"/>
    <dbReference type="STRING" id="590646.G3AWS7"/>
    <dbReference type="GeneID" id="18245402"/>
    <dbReference type="KEGG" id="cten:18245402"/>
    <dbReference type="eggNOG" id="KOG1539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002774_2_0_1"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000410">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="730"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="958" mass="105612" checksum="A37F1C63A5AD69C8" modified="2011-11-16" version="1">MVEPVEKRRKVEQDTVPVSGNGKTNVRKSKVFSPFRVLGNVSNDVPFALGTLGSTFYVVTSVGHSFQIYDVATLHLLFVSQSQTPSKITALAAHYHYVFCGHGSKIGIYRRGRLEETLECPTQSVIHNILTFGEFLVATSRAGEIFTFKKSGKKYPSELHSSLYSINNSIHGEIVGIVHPPTYLNKVVVATTQHIFVLNVNTGKMLFQSPEDQIDDDNISTIEYAPVLDVIAIGTVKGGVYLYNIKKGKVISSRITAADEASGTKVVSLSFRTDGSPHLVAGLSNGDLFFYELEKKSRIHILKNAHKESYGGIANVKFLNGQSIVVSNGGDNSLKEFVFDPTISTTNSSVISPPRHLRSRGGHSAPPVNIEFPQENKSHFILSASSDRSFWSFSLRKDAQAQEMSQREQKSQDNKRQAGQVKSMREKFPEILAIASNQAREGDWENIVTAHKEEPFARTWDSQTKRVGRFHLNTVDGSFISSVCMSHCGNFALVGSVNGGIGSYNLQSGALRKKYMLHKKAVTGICMDGMNQKMVSGGLDGIVGFYNFGKSTFLGKLDLESPITKMVYHKGSDLVACVLDDLSIVVVDVATQRVVRILYGHTNRITGMDFSPDGRWIVSVALDGTLRTWDLPSGGCIDGVFLPTVATGVKFSPIGDLLATTHVTGNGIFLWTNRAQFRPISTRHVEEEEFANILLPNSSGDGGSTLIEGALDDEQNDSLDENSIRDTETEQLDGSLVTLSLGPRSKYNTLMHLDVIKQRSKPKEAPKKPKNAPFFLSLSGDIVGDTAVEDENGQRKINKFRNPEAVDADGMELEDANSRLLKYKADGSSQNFESEFTRLLREGSQTKDYSQFLKYVVDLVPAATDMEIRSLNSFPPLTEMQSFIDALTQGVETNMNYEIYQALFAMFLKNHGDVVYGYNDTELIEALENFTSVNQTKKLALDELAKYCSGVIDVLTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWV5</accession>
    <name>G3AWV5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_100509</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWV5"/>
    <dbReference type="STRING" id="590646.G3AWV5"/>
    <dbReference type="GeneID" id="18245384"/>
    <dbReference type="KEGG" id="cten:18245384"/>
    <dbReference type="eggNOG" id="KOG2282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_6_1"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000016">
        <property type="entry name" value="NADH dehydrogenase (Quinone), G subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.228.10">
        <property type="entry name" value="Dimethylsulfoxide Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="726" mass="79548" checksum="20DBC334625C0CF1" modified="2011-11-16" version="1">MLAARSSQILRNRGAQRFFQSSARVLADVQVTVDGKTVNIEAGSSIIQAADKAGVTIPRYCYHDKLAIAGNCRMCLVDVERMPKLIASCAMPVQNGMVVHTDSERIKKAREGVTEMLLENHPLDCPVCDQGGECDLQDQSQRYGSDRGRFKELVGKRAVENKAIGPLVKTSMNRCIHCTRCVRFMNDVAGAPELGTAGRGNDMQIGTYIERNINSEMSGNIIDLCPVGALTSKPYAFRARPWELKRTETIDVMDAIGSNVRVDARGIEVMRVLPRLNDEVNEEWISDKSRFACDGLKTQRLTNPLIRNGNSFDVSTWDEALAKITEAFKTIQPKANEIKAITGALTDAESMVALKDLLNKLDSEHVTTDVQLSTDATGFDVRANYIFNSTIDGIEDADQILLVGTNPRHEAAVLNARIRKVWLRSELEVSQIGEEFSSTFGLDHLGTDSKALKKALDGGYGKKLAQAKKPLIIVGSGVADSEDLSAIYKIIGEFASKNANFNSPEWNGVNLLHREASRAAALDLGFQTVSKQVAETKPKIIYLLGADEIANKDIPKDAFVIYQGHHGDLGASFADVILPGSAYTEKSATYVNTEGRVQTTRAAVNPPGVAREDWKIIRALSEYLGQTLPYNDIYAIRSRLGQIAPHLVRHDVIEPTSSEVATIGLKDITTRTKSITTVGVPLKNPIKNFYFTDVISRSSPTMAKCIGTFGAKVDKIIDEKPQIDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWX1</accession>
    <name>G3AWX1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_91809</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683898.1">
        <property type="nucleotide sequence ID" value="XM_006683835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWX1"/>
    <dbReference type="GeneID" id="18250115"/>
    <dbReference type="KEGG" id="cten:18250115"/>
    <dbReference type="eggNOG" id="ENOG502RQ1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376415_0_0_1"/>
    <dbReference type="OrthoDB" id="4087712at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="640" mass="72122" checksum="73811CFFEEBFA5A2" modified="2011-11-16" version="1">MDYSDHTFARPPLPSDFSYFSPMTLQRSNPSDKSDPLQRLEVETTSTTSVPISFPYYYIDENNNSFDTFNLLNDGTNSQEAPKYTNTTHNIQTEQNATVGGLQVKKGTASSDSHTKLKQLSDEAFNPVPSRFSQFITEQQQADDLSSNTTSIGSYSDGPIPRSRKGKSYSTTMSKNKMSSSISQGRASKDLRREISQSMESQATIFSTRQDEQPPSTSKTVYRTSSSASTLSRRKAIRFKEGSFIYRMRLRLKKLLKKFKQLKFKIPVSSKRTGNNSIKRSRTKGRTLKRKFRANPKNKAARRFMNISAPINNPSLGRGNATKVNGLDDGLKYEAGAPKENVNMGSRDMKMNHLSSYIDQQQGLYLNNMDQKSESMNYGRTPSIAANTNINTIDGIEEIPVSEYSSIPPPVPKHGNPQTVLGSYDDLISLWRRYLAHVVSKRIQLRQEITYFQEMLVGQELKSGKTSTQSRLSSIYNIDEGDDEYDDEEEEDYEDNELVSDTVSETGTIESSSYVTTSLSSKSEAYSEQQMIKSYIPDATSEKFNRKFNRQSVLSEMLDYESSDSESSTTTSISDQTSPSYKSTLKYTNSSTQASLEIGRQYSIKKKPLIRSLSSMSSHHRGNSPMRRSVGYQMELNMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX26</accession>
    <name>G3AX26_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112414</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683931.1">
        <property type="nucleotide sequence ID" value="XM_006683868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX26"/>
    <dbReference type="STRING" id="590646.G3AX26"/>
    <dbReference type="GeneID" id="18246508"/>
    <dbReference type="KEGG" id="cten:18246508"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017361_3_1_1"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF23">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ICT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="100"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="450" mass="51472" checksum="83A12BB54697294B" modified="2011-11-16" version="1">MSTSSDQNTAFQPPYPLTNAVEANYTYMASLKDWFRQFRLSDEYVESQVLSILPFFPESDGKRVAKIINTPISNNNFIHEFCVDNVESEVSALPDGVKDIVLIHGYAASLGLFFSNFDALSSIPGVRVHAIDLLGFGFSSRPDFPSFKSDTVEDVMKVEDWFIDSIEEWRAKRNITNFVLMGHSFGGYLSSCYALKYNKPQENGKNLINKLVLVSPVGVERNRYSLLKDIPNPFVDDTELNRQNTNTQGPHVEDELLKDQSTLTGHHINPDYKHINMDNSEPETLSRRMKFLIFLWKRNISPFSIVRGLGPFRSKLIGRWTTRRFSDVYAEDADYYQHIHDYFYRTFNGKGSGEYAITRVLDVGAVPKLPLMDRLPMYLTKKKVPTLWLYGDHDWMNVEAGQEIVKEINNIANKDLARFSLIPSAGHHLYLDNPGVFHSVVLKFLKAKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX56</accession>
    <name>G3AX56_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CANTEDRAFT_101139</name>
    </gene>
    <organism evidence="27">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AX56"/>
    <dbReference type="GeneID" id="18245441"/>
    <dbReference type="KEGG" id="cten:18245441"/>
    <dbReference type="eggNOG" id="KOG0399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_1"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="25">
        <location>
            <begin position="46"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1176"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1182"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1187"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EGV66693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="2121" mass="234631" checksum="06ED75A73B57F473" modified="2011-11-16" version="1">MTSYMPQEEFETKVYDYDEVPENKSWAASLPVAQGLYDPQYEKDACGVGFTCHLKGVASHKIVSDSRNLLCNMTHRGGELNPKDGDGAGVLTSLPHKFLKKEFKYTCNIDLPAKGQYGVGNLFFKKDDSIFEKSKMTFEDIAASLGLKILAWRKVPHDSTILGPASLSREPLILQPAIILSELEGVELSEDEFDSKYNKEFQKRLFILRKQSTHTIGLHNWFYICSLSNQTIVYKGQLAPNQVFAYYHDLANSEYEAHFSLVHSRFSTNTFPSWDRAQPLRLAAHNGEINTLRGNKNWMRAKEGIMKSELFGDELDKLYPIIEEGGSDSAAFDNVLELLVINGSLTLPEAVMMLIPEAWQNDKLIDPKKRAFYEWAACLMEPWDGPALFTFADSRYCGANLDRNGLRPCRYYVIDDDRIIVASEVGVIDVEPEKILQKGRLQPGKMLLVDTKEGRIVDDRELKANISSKFDFKSWILANMITMNDLIEKLHSKSVDIKDTIAPSAETVQKDPRLITFGYSHEQMSLILAPMAEGKEALGSMGNDNALACISEQPRLLYDYFKQLFAQVTNPPIDPIREEIVMSLECYVGPQGNLLEMKPDQCNRLLLKSPILATEELNAIRQMTTVYPKWSSSTIDYTFNKKEGIQGYINILDRICQEASTAIANNNKVLILSDKATDADHIPISALIAVGTIHHHLVRQKQRSKVALIIETAEAREVHHACLLVGYGADAINPYLCIETLTRMKDEGLLKNESLTNDKIIANYKYTINSGILKVMSKMGISTLSSYKGAQIFEALGIDNSVIDRCFAGTASRIKGVTFEYIAQDAFSMHERGFPSRDTVKPIGLPETGEYHWRDGGEAHINEPAAIASMQDAVRNKNEKAYDAYVKKEHEAMRNCTLRGLLDFDFKNSTPIPIDQVEPWTEIVRRFFTGAMSYGSISMEAHSTIAVAMNRLGGKSNTGEGGEDSARSIVNANGDTMRSAIKQIASGRFGVTSYYLADADELQIKMAQGAKPGEGGELPGNKVSDAIAKTRHSTPGVGLISPPPHHDIYSIEDLKQLLYDLKCANPRARTSVKLVSEVGIGTISAGVAKAGAENILVSGHDGGTGAAKWTSIKHAGLPWELGLAETHQTLVLNDLRGRVVLQTDGQIKTGRDVAIATLLGAEQWGFATTPLIAMGCLLLRKCHLGTCAVGIATQDPELRKKFKGTPEHVINFFYYVANDFRKIMAQLGYRTVNEMIGRTEKLIVRDDLRNTKNANIDLSPILTPAHSIRPGVPTYCVRKQDHRLHVRIDNKLIDESEITLAKGLPVTIDCDVVNTDRSLGTTLSYRVSKTFGEQGLPHDTIHVNVKGSAGQSFGAFLAPGITLELEGDANDYIGKGLSGGRIIVYPPKESKFKAEDQIIAGNTAFFGATSGSAFIRGIAAERFAVRNSGANIVVEGTGDHGCEYMSGGRVIVLGSTGRNFAAGMCGGIAYVLDMAQDFADKCNMGTVELSSIEDPSEIAFVRGLIEDHRHYTGSEVADNVLNDFNRILPRVVKVLPTDYKKVLEKEKLQKLEAKQNEMNRFLKSIKEDPEADVTNGEAAKIKHGHVHRPSKKNEPKVLDLEDTIPDTEVAKKAVAKIDKVKGFMKYKRRNEKYKDAKERTNDWNEMTTRLTKDELKYETARCMDCGIPFCTSDTGCPISNVIPKWNELVFKDRWFDALQRLMMTNNFPEFTGRICPAPCNGACTLGVIDDPVNIKSVECAIIDHGFEQGWIKPQPPKVRTGKTVAVIGSGPAGLATADQLNKAGHLVTVYERSDRPGGLMMYGIPNMKLDKGIVKRRTDLLAAEGIEFVCSTTIGEDITLDELKAQNDAVVLAIGSTIPRDLRIPGRELNNINFAMQLLSKNTKALLDGTLDDIKEEIEGKHVVVIGGGDTGNDCLGTSTRHKAKSVTNFELLPTPPNMRPKDNPWPQWPRIFRVDYGHTEVANHYGKDPREYSILSKEFVDDGEGNVKGIKTVRVEWKRSDSGAWQMAEVPGSEEFFPADLVLLSMGFVGPEADNLGVSKSKRGTVDVTDPNGYKVVGDDNVFTAGDCRRGQSLVVWGIQEGRQCARQVDNYLMGTSRLPGNGSVEQRNYKLLEELAEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXB2</accession>
    <name>G3AXB2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112078</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXB2"/>
    <dbReference type="STRING" id="590646.G3AXB2"/>
    <dbReference type="GeneID" id="18246349"/>
    <dbReference type="KEGG" id="cten:18246349"/>
    <dbReference type="eggNOG" id="KOG0900">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_0_0_1"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000004">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="118" mass="13237" checksum="3DE550AEB1B67E6C" modified="2011-11-16" version="1">MSAPINKEKVQEQEQEIHKIRITLTSTKVKQLENVSANIIRNADQSQIVKKGPVRMPTKVLKITTRKTPNGEGSKTWDTFEMRIHKRVIDLQAPAAIVKKITQITIEPGVDVEVTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXN4</accession>
    <name>G3AXN4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_118126</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXN4"/>
    <dbReference type="STRING" id="590646.G3AXN4"/>
    <dbReference type="GeneID" id="18248622"/>
    <dbReference type="KEGG" id="cten:18248622"/>
    <dbReference type="eggNOG" id="KOG4685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012847_2_0_1"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="267"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="391" mass="45396" checksum="155B0CFBD45D07C2" modified="2011-11-16" version="1">MAKRRYNKKKYEGPLPVTLSSTVYGPLPEVYPHNPLSWAYFAYKYLVLLTKPVPQGCIDNIVVNCEHTDAGAVFTVNDLSEMTRLWDHGCYGKGIFSRSDPTWYSRTTRRLHLNHSSSEPAELSNEDITRFRREERSRFKAERTREQQLKTKRRHTPLSTEEKQELQEVESVLLAFRRSNRLKVQKEQSQPILWGDMRDEDQLNVDKETMELVNIEALQLQPVELFFLKYGLDVVDVISSQDASALSTREVFFACCGTRTPIPSTSFIVQYVVYHYYRSLGWSVRSGIKFGCDFILYKRGPQFSHAEHAVLVIPADGQHEKSWVELQTLSRVIGSVRKTLVLNYVEMPSVADFTAVLHPDQSDETLFTTLLRLYRVNEVVYRRWVPNKTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYE1</accession>
    <name>G3AYE1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Not3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_92168</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYE1"/>
    <dbReference type="STRING" id="590646.G3AYE1"/>
    <dbReference type="eggNOG" id="KOG2150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020483_0_0_1"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="697" mass="78853" checksum="020764238258D4AA" modified="2011-11-16" version="1">MSSRKLQKEIENTFKKINEGLESFNYHYERHQDLNGQVLDRNLESQKEKLETDLKREIKKLQKNRELIKNWQSNDSVEVVVTRNKLQEYRRFVEEAMEKYKEVEKSSKMKSFSNQSIMLATLEDSQHLTKEAIEVIGFLEDSIEEINQQIETLEADYEKISSRKTKKNSSVESEKQEIETSLSRNRFHLESFEKIIDFVKQRQIDPELVVKIQDDINFYLESNQEPDFIDDEALYDEIIQQAESKYTYVPKQDENTLQDIIENYNNESNGQAASGTTQNSNANAPAATIPTSKKQPQIASKSKSPTPITPTKKSVEATTPIKNRGSTPDIDIVQKLKPAATPSKVSGEVAWSSVARVNAAVAGISAAPSSVESERASLVNNGSNNSSKKTTNDSSVSLESGITDDTSVHNLEFNGSLNKSEITNELLNTQSEDPIFPYVKVLVNSGLSSSELKVCSDYNLTKVPPGIQSLILSFTSTRNIKSSDEHSDYNEQGKLLHSSPDSDQLFLPIRKPYIPIGVQNSYYQHTSPFTHTQFVKPPLHLLTYQNTWDKIRATGSYDLFVSDILGLIENQKNAVLAGQASMNMAVVNELMMAFFYGFFYGLTPLENLLAESKLFQLGWKPYTIKAVNQLLLQTPGSLNSDKYYYWVRNMKSTTGTQEQIEFGDYQIFDLSSWEIHLKLGFRLDNSLAESNPMPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYF1</accession>
    <name>G3AYF1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="6">PME-1</shortName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_133257</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYF1"/>
    <dbReference type="STRING" id="590646.G3AYF1"/>
    <dbReference type="eggNOG" id="KOG2564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024818_3_1_1"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="100"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="333" mass="37604" checksum="3617350658EB4BF2" modified="2011-11-16" version="1">MSDLHKQFLKRVKQQEQAFGLASLSEDGGGDNDTVFFPPAKQQIETKPKFDRTEINHEGIFKNYEMERNSTFPIIESYKDQKSGIVFQVYFKPPSSSKVPIFVGCHGAGSSSMTYCKLAQSFNKTYEEESCGIFLFDMRGHGGSTSIEPLDFSLTTLTEDFAFVLEKFYQKHNIESVLYLMGHSLGGSVLTNYLHHYPDNQFNIKGLIMLDIVEETAVTSLGAMPAFLERIPKRFATYKQAIDWHVKATNLLKNTESASISVPDLFVDDGEVLKWKIDLKITKPFWDSWFKGLSANFVSCGSKQHVAKLLILAGHETLDTSLIIGQMQGRYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYS1</accession>
    <name>G3AYS1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_133343</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYS1"/>
    <dbReference type="STRING" id="590646.G3AYS1"/>
    <dbReference type="GeneID" id="18249697"/>
    <dbReference type="KEGG" id="cten:18249697"/>
    <dbReference type="eggNOG" id="KOG1490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011784_4_1_1"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1190:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="11">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="575"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="442"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="644" mass="74649" checksum="A7A1B631BD62A5E1" modified="2011-11-16" version="1">MQLSWKDIPSVPNTNDMLDIVLNRTQRKTPTVIRPGFKITRIRAFYMRKVKFTAEGFSEKFTDLLAGFPNINDVHPFHRDLMDTLYEKNHYKISLAAVSKAKTLIEQVSRDYNRLLKFGQSLYQCKQLKRAALGRMATIVKKLKDPLVYLEQVRQHLGRLPSIDPNTRTLLICGYPNVGKSSFLKCITKADVEVQPYAFTTKSLYVGHFDYKYLRFQAIDTPGILDRPTEDMNNIEMQSIYAIAHLRSCVLYFMDLSEQCGFSIEAQVKLFHSIKPLFANKSVMIVMNKSDIIKFEDLDQSKQEFLQSLYDLKDIEIMNTSCVEEENVMQVRNQACEKLLASRIEQKLKGAARVSNVLNKIHVAKPAQRDDLDRPAFIPDSVKELEKYDPLDPNRRKLARDIEAENGGAGVFSINLKDKYLLEDEEWKNDVMPEVLDGKNVYDFLDADIAAKLQALEEEEEKLEQEGFYDSESDIEDDEIIDIKEKAEWIRDKQKKMINEARNRKALNNRAIMPRDKIKRSFDDMEEHMYTIGHDTTELRNKQVIAKAQGVKNHKGINIKKKLQDLDVDVEEHIRKKKRPAHQSDRLNDGLTSEGLKEKTERLNKVQRRERNRQGKIGESDHHIPTLLPKHLNSGKRSFSADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYZ3</accession>
    <name>G3AYZ3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112841</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYZ3"/>
    <dbReference type="SMR" id="G3AYZ3"/>
    <dbReference type="STRING" id="590646.G3AYZ3"/>
    <dbReference type="GeneID" id="18246700"/>
    <dbReference type="KEGG" id="cten:18246700"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_1_1"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000004">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="15"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="575" mass="66540" checksum="FA9201A3C8103DAA" modified="2011-11-16" version="1">MTKDYIWWKDATIYQIWPASYKDSNNDGVGDIPGIISKLDYIKSLGADIIWLSPMYDSPQDDMGYDISNYNTIYPKYGTMEDMDNLISGCHKREIKLILDLVVNHTSSEHDWFKESKSSRDNSKRDWYVWKPARYDSEGKRHPPNNWKSFFSESAWEYDETTDEYYLHLFAKSQPDLNWENETTRNAIYEYALDFWFKKGIDGFRIDTAGLYSKDQSFADAPIVSPGEELQFCGNSVNNGPRIHEFHKEMFEKVTSKYDVMTVGEVGHCSREDTLKYVSAKEREMSMVFLFDLVSLGYSSTDRYQYDGFSLKDLKDAIVKQCNFIFGTDAWSTMFIENHDQARAVTRFGNTKTLDNTFKSAKLIALMQATLTGTLFIYQGQEIGMTNLPRSWDISEYKDIESNNAYQDLLKTHNISDPENDSRVKRFMDTLALVSRDHARSPVQWTADKHGGFSGTKPWMRVNDNYKEINVESQVGDPNSVFSFYQKCLVLRRQYKDLFVYGDISVLDYENPQLFSYVKQSGTSKAYVVLNFSGEPAKFESSVPGTLRLLNTNVDDFKDDSLSPWEGRVYLVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ67</accession>
    <name>G3AZ67_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="4">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTEDRAFT_119090</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="4"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AZ67"/>
    <dbReference type="GeneID" id="18248680"/>
    <dbReference type="KEGG" id="cten:18248680"/>
    <dbReference type="eggNOG" id="KOG0230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000480_3_1_1"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000510">
        <property type="entry name" value="Phosphatidylinositol 3,5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="273"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="21">
        <location>
            <begin position="1866"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="665"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1524"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1594"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1734"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1676"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1532"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1600"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1752"/>
            <end position="1776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV66020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="2201" mass="249678" checksum="0F555B1A6C1D85FE" modified="2011-11-16" version="1">MNNSNVSVYGSDSTNIDNDDRQDANDEVKNPGLQKPQDQTSKVTSDSKTLRFSKQSVPVLEATTESVTSSVINVNALANTEPDSTSKTNTPSLKDTSVTASNRVTKKRSLKNLPNRISSIFTNLPNDIELSDDSASDTETVNDTSFLGGIPENSSLNQAGAVPPPELAMYRETSVKSSPVKARQVRSPTAGTDASPTMNSFNTLKQYNMKKKSSNLSASLIDNARSIINQNFHGNISSASSFVEKVTKKKRKTRPSQNPLKSGGIPKKYWMNDAFVSECLNCFKPFTAFRRKHHCRFCGQIFCSRCTLFISYQEHKEQRKTGVINPDKRSYKDKLRVCRPCYSDVIVYLSDSDSSSSESEQEVEDDAVSFETLDKFKDDNLPQHPFVKSRSRSLSTSRRDFPFEGNKSFLKPALHDDKTTVKSPLSLAIPSARKGDLLEVQYSKSNVNSSFSRSTSQEPSGASWLKNYPHLRRSKTQQNTGLSRSNSFDNSSSLHGFISGKTDVSKKGKSMIFGDTNGDDPDDEDDEFESENEDEQVMSLYTSLNHSGFNGNANSSTISPRAPITRPLANVSANAVPTLGEFPTMLVNEKLYPKNMSSGLRSSPAGAVFPVFIPNNTKTDIDISADGGSVPRSVLEENPKSNLRSHERAHASLLRMRSRRRAKTARNLSLLTQNPTRLPQLEFSDLRDSSSPISTPTSPTPGSGPSGAYFKDLITNEGFSPLDKSPSDPQTRHQISYGSLNNFDADDSDSITRGLSGKASREGLFDEIERQLDSVYLELFKKILDQCLKDCDIKDDTQRWSNALTMSINFVNGLKLTDTLDIKQYVKIKKIPGGRIEDTQMINGLFMTKNIDSKKMSSRLSNPKIALLMFPIEYLKQKEQFISLRIVQSQQDVYISNLVSRLISLEPDIIVVGDTVCQLAKDFLEDANITVISNTKPQVIERISRYTRADIFQSVNDLFFKKGTLGTCQKFEIKKHLHGNVLKTFACFTGTDTELGFTITLRGGDEETLNSIKYATENLLSTQINAKFEKSYFEDSKLVYLEDLPNESVSSLSSKLNQIKSEAEIENMGIEIIPDEKEVFGYIAMFINRHISTSPAAKFSLPTPLVNAVEAFFVFHNFNERNKLLKSNESLDDVEMSLIEELKLNIGLENMPNKAQDLLKFVKHAAEVKSKILLNQFQSRARTWANYLKLPSYQLYPIFHRNIHLLYSSVSKKFNTPCSGPNIIVVDFYTDNDKFLGLQLDQMFSESLTDCDECGEPMIDHYRNYVHGTGKLDMVVEKYEALSAEHKNFPNQRTMWSVCKQCNYKTPVVLMSDDTYYFSIGKYFEIAFWGRNVTLNNQGECRHDFFKEHIRYFGFNDMAIKVEYFPIDTYEVVVPKKQTEYDTSVEINLKVEAFDTIRTKSANFFDSISKRLNRVKVDTFDKAEDGAKVIEQMKERLDQQRSILEEDLLNIYNSTPSTYYLPMNSILRELQELGVAWDADFNDFETQFLPSENEITRITQFHLRNFLIDKYNIDNAKEVEMNDMSKSVDSVGSEKEGLSSKSDEKTVKQQDKDSELVQNLNESPRKEIGKLIPRALEGPGSNVVDKVNKIEQKLEHERIQNTGSRVSSGTGSMTDERKSGFSPPKKASSKLLGRKSSDLSISSVNSQLGVNSNKPVTKVSQLTNFFDQMSFDQISMEFKKQREQELRKNLNKFRALPIVASKPIVEMYNKIEDVVNADELEVEKANRRLPRRLTSDSLIGKRPDESTAPDLTRARPSDVNDSKDRDKQGEKLKEKDAKAIENLKSKEKDKLLDIPQPERVSLLKSLTNFWADRSASLWDPLDYPLDSTEHTFADSDIIVREDEPSSLVAFCLSTNDYKQKIKSLAQEPDDDIKLDSEVNNKKFNSFAKIEKKFKNRFDNSKKPSELENILTKNKSTHLKYQFADGSTTLSCKIFYSEQFEALRKACGKEDRFLQSLSRCIKWNSSGGKSKSNFLKTLDNRYIVKELSKSELESFVPIAPFYFKYIGQSMFNTLTTALAKIFGIYQIQIKNIITGKTFRMEFLIMENLFYNNKTTRIFDLKGSMRNRHVTQTGKEDEVLLDENMIEYIYESPLFVKEHSKKLLRGSLFNDSSFLSAMDVMDYSLIIGIDDQTKKLYIGIIDWLRTFTWDKKVENWVKGNNLIGGNKGKDPTIITPKQYRIRFREAMERYILEVPDIWYEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZM3</accession>
    <name>G3AZM3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Temperature shock-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112491</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZM3"/>
    <dbReference type="GeneID" id="18246543"/>
    <dbReference type="KEGG" id="cten:18246543"/>
    <dbReference type="eggNOG" id="ENOG502RZ9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129392_0_0_1"/>
    <dbReference type="OrthoDB" id="4069694at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000992">
        <property type="entry name" value="SRP1_TIP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00660">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00724">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442664" description="Temperature shock-inducible protein 1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="16833" checksum="EA8154D532919085" modified="2011-11-16" version="1">MKFAAAIALLASVCAVQAADSEDVAFLTNLVQDYKSHTADYAKFIRTASSVPAVITSLALHVATYTDTSYTTLLDNNGLDIDSLEDFATELPWYSSRLLVADADASESGDASETDASDASSTEASSSAASSAASSAASSSAASSSEAGAAAMMAPIGALLGAAAIALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZW2</accession>
    <name>G3AZW2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AFG1-like ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_119392</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZW2"/>
    <dbReference type="STRING" id="590646.G3AZW2"/>
    <dbReference type="GeneID" id="18248698"/>
    <dbReference type="KEGG" id="cten:18248698"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008681_1_1_1"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="55474" checksum="46B87C9490556363" modified="2011-11-16" version="1">MNKLVAIRRFATSRVWRITPLELYDTRVQAGRLRDDSYQRKIISNLSVLHQNLSEYQPPPVETPNIDDLKPKSSLSKLLGGFLRSTSIKEPNVDELLEKDNPVKGIYLYGDVGCGKTMLMDLFYETIPGHLPKKRLHFHQFMQNLHKRSHQIKLEHNHHDMDVIPLLASEIAQEATILCFDEFQVTDVADAMLLRRLMMMLLSPEYGVVLFATSNRAPDDLYLNGIQRKSFIPCIKLIKKQTRVIYLNSPTDYRKIPRPMSSVYKYPKPGVKYTSKSFQASKAAHIQEWYEYFNKENDDQTVVLNYRLNVWGRELVVPRCSYPYVAQFSFEDLCGKPLAAGDYLTLATSFQSFIITDIPYLSIDVRDKVRRFITLLDAIYDNHDRIAVTSAASFQDLFVEPEDLQKDNFSLYKKQQEQGSEETFEDDELVTKHGFDKRVAKTASMFANDEEKFAFARALSRLSQMSTTDWIESVRPVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B008</accession>
    <name>G3B008_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_97213</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B008"/>
    <dbReference type="STRING" id="590646.G3B008"/>
    <dbReference type="GeneID" id="18250668"/>
    <dbReference type="KEGG" id="cten:18250668"/>
    <dbReference type="eggNOG" id="KOG4139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023948_0_0_1"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="481"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="546" mass="61943" checksum="1EFE71F96FC769A3" modified="2011-11-16" version="1">MDINRKRVARPPLRETSGNVPSPNKKKLKLSAKESVSLDVHTPQLTHPQPAGSLHHQPEHSDTLAPAALQSSSNGGSVRSALLARSVLKVDSYKAKSNRLMGDELSEWRSNWRKIMKSSVVYFDTQGFESSNHVSEQKRAHKGLKYVGSLVVPFYDKDVTIIVSRRPYNPAVSYPSNDIFHDASSLKIKVWNFDKVFRFLSNLGVNDSEYMSSANYENGDLVNLLKEEKIFGSTDKDPTAKREDLHYLDNNYIYVYDLSQSVRPIVVREWNAENKYPRFFLTLDGKCPFIQDTENSDRKKVRRAKKYEETSHYRQLLKIMAYELVQKPQDRRISTSSLLTSTAIEEDTNSHPNHQQNSNNDSTISQGSNPEDNEASVETEPEDLACKFKHPKPNLMRNSSCLPTNNSNSNSNSRFYDVAASGFNGTSNAVQMSIDSGTFPGGGNGLGPTMSQVPSKNINNLKRRIFMKKQKQSMVEKDENKDLKPGYCENCRIKYDHFDDHINSSRHRRFAMDDGNFKDIDNLISTLNENKVFGFITSDGDFSYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B090</accession>
    <name>G3B090_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_133645</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685032.1">
        <property type="nucleotide sequence ID" value="XM_006684969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B090"/>
    <dbReference type="GeneID" id="18249732"/>
    <dbReference type="KEGG" id="cten:18249732"/>
    <dbReference type="HOGENOM" id="CLU_343543_0_0_1"/>
    <dbReference type="OrthoDB" id="4026483at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="842" mass="97336" checksum="0AA4C9AD00D03D21" modified="2011-11-16" version="1">MAAKKRQRIILVCDNCHHRKIKCDRKLPCDSCKARGISALCRYSDLEKELVKQGKSTHEVKSSDEPASELTVLRHRVKELEAMIGVASLSNSNSSFNTPSDFQSSPSTTEYSDTNETTDFFMIPFENGSCVRVNQSCIISFPISFLSILRKDAAYLSFWHYNRNPSQQDKFLKHQVEGMGQLLDHRNEELTQTVDSRAQEYFGASYIPKYVKNSTISLDVKIAINLYMGQFGPLMFYDNYIPPNSSIYVKATHILPPKPIILEYLTVWFEKMEPYFPIFEKIAFTAVISRLVSDRDNGDVRVKLSIEKKPDLANLASLLFILRLTYSYVMVANNTTNRYKNLEKFPVYIDAVHIAKECLKEFNMSLRPSFEALQAYSVAKVYKSYSHDEGDGIRETDMYVRTLLYAASSCGLNRDPDIYHHEDLTWIERNHRRKFWFFLLSQEFFESALYGRRLFELDYADVKLEETNTPGDDFIYHTFLKILPMRGLMVKLMKMLMNINVPTNVTLFIDLSEQLAALVDNAYGDLSTQFHNQVNMFDNPKSTWDTYHLFAMKLLMMKLNYCLYIIFEKKGDISQSFKFYKRLSIITFIENTPLISVAFDNDNRVDPMFSIILGSSFLRLCFIYILNCATFTIHVNHTIRLYAGTEDKPKHLFELVKNVQYLWCYICTYTGCLSRRTFTAWRAMKASLYGMIETGSYQTFEDICLGRKASWSFTSAQMHELCEILEETVAVVAAKPSMVPFELSTQLLWLNVVPFDNSKSVEENMDIQRLHVNQIDNTWNNCVASMKETIPASFKNDETLQTTQIDNLLNTDVMDPSIGIMSGVENMFSLDDLFVNDTFFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0A9</accession>
    <name>G3B0A9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_113074</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0A9"/>
    <dbReference type="STRING" id="590646.G3B0A9"/>
    <dbReference type="GeneID" id="18246814"/>
    <dbReference type="KEGG" id="cten:18246814"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="48"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="534" mass="57513" checksum="08878F2A977AE3AC" modified="2011-11-16" version="1">MSKPSPDYQSTENLDLSSETSSQHLVKDNVSTTTDTSKTKPSRLVILLTLASSISGYMFGYDTGYISGALVSIGTDLSNKHLTDGEQEFITGATSLGALLGAVVGGVLANFLGRRMVLLGSNVIFVVGAIIQLAAKTVWTMIVGRFVLGWGVGIASLIAPLMISELAPSRYRGRLIVTNSMLITAGQLIAYFINWGLTRVNHGWRVSVGLCIVPAVLQFGLFWFLPDTPRFYIINNDPVNAKMVLKKVYKDADDAFIESEIAEMVASNSNVPGDGPVSRAWNSVKLLHSTPANLRALILACGLQGIQQFTGFNSLMYFSATIFETCGFNNATAVSIIVAATNFTFSCVSLCIIDHVGRRKTLCIAIPIMCIALVICAIGFHFLGVKFGSSDEVIVKSSGISGWGIVVILSMVLFVGSYAIGIGTSAWTGVELFSDVNVRSAGAMFAAGTNWAGSLTISSTFLTMLEKITPTGTFSFFAGLCVISFFFIYFLYPEVSGLELEETTRLLTDGFNVKEAGRLSKERKHRKPKTQPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0L4</accession>
    <name>G3B0L4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_119827</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0L4"/>
    <dbReference type="STRING" id="590646.G3B0L4"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272246_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF78">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G07240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1109" mass="129786" checksum="350FDD01318EB911" modified="2011-11-16" version="1">MKKISTNRLTVEESISIQKLFYNILDWSTLADGENEDDFLLACEIWHASFSKLEPELTKLQELLVAKRDIFVHVMMNNRNYLAYEYLMKSLVDAHAQIPKKWCDVQAETFGFTKENGKTVFNTDKISAFLSDPANSKQSKRTLISSFLRIGIHNDRSDQTNLISQFIRFLMQTTDQHLLLTKNAHSSYRSALYALVDYYEREENSIEEIGGIFEQLFLRNSDVFYNFLSTMLKAASIRAPIQAKKYWAYKRQCSQASERDHITPDDLTSVMSALFSLRDFEGVSAISKNHPDHYHENQLSIFLKVSRAKNDWKMLQDQFEAMYGKGHLPYATHYSIVMNSLAALGEKTDIDRLFNQLKKRNITPTPSIWGALIKCRIVLNEFEEAQTIFEKYLEELSRTASSGGSTSSQTASIYRLMMSVKLKSPNKKEVLTFFESSLDRQRQEDVVIVDSKTVTKVIRYFEEAYAFKEVQYVREICEKLDIMDEDIYCSLIRAYSRFTQHEMADNLALEAHHKSITPLMSSRILKEQLKNYRHWFKNRDTKEEKWYIEARSEQIIKSVYRENTSKHDLQGLYVEVERYFSDTFQVGFAFRYLEKIKAIGTPREEAYIPLMKHFASKNKIQGYQKIIQLYKEMGSLGIKCSVHSFKFLMKAVLFVDQHVNQNFSRSEKLLESILMTNDFQFPGSNSRLLEKEGGPTRTAKANIDHVATGLCQVVSDYLRETPGSQAEKAEFLVDFLSQLRERLDHKMKLQVRLSVYLEMGKLYQRFGNLQAASSLISNGIAELNTFIERYIEEYPVPHDYNFEVVIPRSIMRNYRTLMYLHIQVLRQNRSSPEAYLEIAKNCERNNIRLNGQDNNIIVEELMKMEKFKAFDNIFFITENFLAAGNLNEVSLQRHLQTLYTLFMREKCKVTSTSRLKSTYSILNDFYNIGDLEQLKKGSRENTSGRSQFVSALKSFGKRFSDVGDYDINYVMKNPEIFFSPEKRLTSVNKLQPIISILLFRYLKGYTRMNKQKLFLLMDKYPESIECLFLSQASKFRTETFRARINRIISPPADKIESFLERRIRTRRALRRIFKSDDDMDRDTDRDAQLDDHIDDYEYQQNTTDQNHFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0R3</accession>
    <name>G3B0R3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_119912</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685141.1">
        <property type="nucleotide sequence ID" value="XM_006685078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0R3"/>
    <dbReference type="GeneID" id="18248734"/>
    <dbReference type="KEGG" id="cten:18248734"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_1_1"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="620" mass="68300" checksum="21C5418A0659724D" modified="2011-11-16" version="1">MSAKVSSEAGLSDSVESKVSGLHSSEVEEQASEKSSRDGKPVELFRSRQGQKVLTLAYFVLVMTAFVENFANDSTSGLSSYATSEFNAHSLIATAAVVYKITAIVTYPIMGKLHDLAGRSQGFGFAVLLYTLAYVLYASCQNADTYVCAEIFFAVGKVGYRVFQQAFIAENSSLINRGFLSQLPDAIAGVPSLYVGSVIQDAYMAHTGWRWGYGSFAIIMFVACILLTAFMYYVDTKTKQDGNHRMIDAFKDLPEGPWYKKTAYFLFVKLDLFGGALMLVGMCLVFVPLTLTGTKSSYKWHEAKLIAMVVVGFVIFVTFLLYNAKVPKHPFLPKGTMTSTMIIACLIASCDWCCNSAYATYMKTVLQVGKYVSVGEATRIDDSKKACLQIFNVVGGVLMKYTKRSKIFIITSIPIYFMGQVLAVCFINYHGGVADRGLLYMFEVFIGASRGIYTTALQVIIQGVAGEQGIAMSTAFFLAFSSAGSLIGSAISGGIWNSVVLQKLDKYLPEAEKANATKIYKSLPVALKYKKGTPERDAISLAYRETQQIIGWVTLGILVPMLVLMWFVKNIKLTDHVDIYQTDSELESTLDEKVQPIEVVATSEEIPRSRKQKFYDLIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0X3</accession>
    <name>G3B0X3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_104476</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0X3"/>
    <dbReference type="STRING" id="590646.G3B0X3"/>
    <dbReference type="GeneID" id="18245719"/>
    <dbReference type="KEGG" id="cten:18245719"/>
    <dbReference type="eggNOG" id="KOG0323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007683_0_0_1"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="161"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="525"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="692"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="788" mass="89284" checksum="4A578FB03226666A" modified="2011-11-16" version="1">MSETVPITLPSSVPFPVTISSILCSSGDSIRKRQTIFKYKYWDYQDDPNSKDDPPPKIRVERIGAYESPVEGEVLGIKTHENAEINHSGIVLCSIREPCAHAVQYGGLCALCGKAVEDEKDYTGFNYEDRATISMSHDNTGLKISYEEAAKIEQNSTTRLTQQRKLILVVDLDQTVIHATVDPTVGEWQSDPSNPNYRAVKDVQSFCLEEEPITPPNWSGPKLSPTKCWYYVKLRPGLEEFLREMAEIYEMHIYTMATRNYALAIAKIIDPEGEYFGDRILSRDESGSLTHKNLKRLFPVDQSMVAIIDDRGDVWQWEDNLIKVVPYDFFVGIGDINSSFLPKKNTQITGPSKKRKSIAKLEAMEEDLEHEFAESDNGDAPDSESDVSDTGDSKEDKENIDHSHSAVDRLVEIGGGEDNKNLLIEQSRSRTLSLEQQQHDRPLAKLQHDLEKINHDHETKSDSEHSSNENDDAANDEEEDNLLYDDDNELESLKVALSNIHNEYYKILDSKNPERPDLTYVIPNLKSKCLEGVVILFSGIIPLGINPDSADIVIWCKQFGVKVVNEVYPEVTHVVCRDPNSTNFKGGLTFKVKAAKKLIPNIKIVTPDWLFVCLSSWKQVDEADYSIDEGSQNWYVDERDLDKYQKALQEQKQQQHETIIARPRFDSIASMEDYDLDEANEEVDDFLAGLSDDDEEENEDHENSDDEDDEAVPAAHDSFIREAYLSTSKKRSRDDEADDSDQGPNEVPHAKKNKIVGKGEVAPEQENEEAELYELEQELLDGFDDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B178</accession>
    <name>G3B178_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin/actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113660</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B178"/>
    <dbReference type="STRING" id="590646.G3B178"/>
    <dbReference type="GeneID" id="18247072"/>
    <dbReference type="KEGG" id="cten:18247072"/>
    <dbReference type="eggNOG" id="KOG0678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_3_0_1"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="423" mass="46899" checksum="589444AC7ECDB4CC" modified="2011-11-16" version="1">MASMGTPAVVMDNGTGLTKLGFAGNDSPSFIFPTAIATSTLGGKSTKSSASNSSSFLASKRGLEDLDFFIGDEALSAANGSNYSLSYPVKHGQIENWDHMERFWENSIFKYLRCEPEDHYFLMTEPPLNPPENRESTAEIMFESFNCAGLYIAVQAVLALAASWTSSKANRTLTGTVIDSGDGVTHVIPVAEGYVIGGAIKNIPLAGRDITLFIQSILRDRGEVDTTLQTAEKIKQQFCYVCPDIVKEFKKFDQYPEEKFAQYIVEYTDKNKTNTVDVGYERFLAPEIFFNPEIASSDYLTPLPTVVDQVIQASPIDVRKNLYKNIVLSGGSTMFTSFGKRLQRDLKGLVDERIQLSERLTGNKSSGVKVEVISHKKQRNAVWFGGSLLAQTPEFKSYCYTKQDYDEYGPSIVRNFSLFSVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1E1</accession>
    <name>G3B1E1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_121180</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1E1"/>
    <dbReference type="STRING" id="590646.G3B1E1"/>
    <dbReference type="GeneID" id="18248828"/>
    <dbReference type="KEGG" id="cten:18248828"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="3">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="487" mass="53429" checksum="A43585D901D543BD" modified="2011-11-16" version="1">MSGFRLLDLVKFFLPILPEVELPYEKVTLDEKIIFTVSSGIIFLLGQLPLYGLKPNAYLYIQDPFSDFRSIFAMEKGTLLELGLLPVLTSAFIWQLAVGFKVINVNLSLRSERELFQTGQKLTTYGLSIVYLAGLLFSNYYDESLKSYVIGGVAAWGSLFLIFVQVFIFNFFVTSIVEVIDKGLGFGSGALTLLTVQYTSNFVRDLIGLEILPLKNSNKTESFGSLANLVKNFSFNPKTLGGNVLNSFTRFELPNLTQAYIAVASILVVVGLNNFRIELPIRSTKMRGMANVYPIKLLYTGGLPLLFTVTILANLQVFGYFIASIFQYRFLGSYELVNTSLVLNNGILYYFTSPSVVQAVLNPLRTVVYSLTVVFLSTWFANHWALFSGSAPKDISKQFKEQGISISGKRDVSITKELSRIIPVAAVSGAFLLSVTAIVGEVLGGKGKGIAGVVGICAAFSIMEDFVIESQQSGGTSQLLGALSGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B271</accession>
    <name>G3B271_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_113389</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573</strain>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B271"/>
    <dbReference type="STRING" id="590646.G3B271"/>
    <dbReference type="GeneID" id="18246934"/>
    <dbReference type="KEGG" id="cten:18246934"/>
    <dbReference type="eggNOG" id="ENOG502QR1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036959_1_1_1"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14 17" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="151"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV65061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="343" mass="37915" checksum="BD276023EE07603C" modified="2011-11-16" version="1">MSSSSALRVAVTSSKFTFPSSAFVATGLGLAGLYYYNQERPNPTPSLNPLLAAAPLAAVVAGKSQADFQSVYNAIALKVQDQDDADNGAGRYGLLTRLAWHASGTFDKKKQAGGSYGGTMLYAPESTDPGNAGLEVARDFLAEFLVEYPWMSRGDLWTLGGVVAVQEAGGPKINWRPGRQDISDKSKVPENGNLPDASKDGKYVRGVFTRMGFNDRETVALIGAHCLGRCHTYNSGYDGPWGPSFNMFTNDFYVRLLQGWHVRKWDGPKQYEDDETNSFMMLPTDMAMKEDSHFLKYVKMYAEDQDLFFNDFSAAFTKLLENGTQFTTDNKHLVFQTLDEQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2F5</accession>
    <name>G3B2F5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_120475</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2F5"/>
    <dbReference type="STRING" id="590646.G3B2F5"/>
    <dbReference type="eggNOG" id="ENOG502QPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_0_1_1"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442803" description="glucan 1,3-beta-glucosidase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="13">
        <location>
            <begin position="96"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="486" mass="54690" checksum="CF97003CFD03D501" modified="2011-11-16" version="1">MHFFWWSVAFTLWTAVSAFNVTLPSNGSLYQPATTSRNLQLKGVALGGWLVLEPYITPSLFLAFNATNGTEADIPVDEYHYCKALGPTEAKKRLRKHWDGFYNESDFETIKSYGLNMVRIPIGYWAFQRLDSDPYVAGAAEYLDKAISWAYKNDLKVWVDLHGVPGSQNGFDNSGYRDIGYPGWFNHTENVNVTYAVLQQIYAKYGGSHIASQYPDTVIGIEVVNEPYSPKISMKKIETFYRNTYADARRIQKVNNTIVFHDAFKSAGYFDDFMTFAATSNTSNRTTQNYNIMIDHHHYEVFDSGALNLTVAGHISNIKGYSEGIHDELDSHPAVVGEWSAALTDCAPWLNGVGIGTRWEGTSPYTNDAIGKCDDVNDFSAWSDDRKKNYRKFIEIQLDQYESQTSGWIFWCFKTETSIEWDLSRLVDLELFPQPLDDREYIVNGTDTDPDARDADDDGPAGKESGAGCVTASVMAVVMAVSIYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2J3</accession>
    <name>G3B2J3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division control 14, SIN component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113479</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685497.1">
        <property type="nucleotide sequence ID" value="XM_006685434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2J3"/>
    <dbReference type="STRING" id="590646.G3B2J3"/>
    <dbReference type="GeneID" id="18246979"/>
    <dbReference type="KEGG" id="cten:18246979"/>
    <dbReference type="eggNOG" id="ENOG502S6JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1069869_0_0_1"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="265" mass="30069" checksum="9F4BE54D4899C1C8" modified="2011-11-16" version="1">MTVSDHELEASILKIKDLLNADPSKQNLADAIDLLNSLLQSMMPSIQAQRTPMTMAPFSANSSSSKLVRFVKLQDNFRFSLVLSIDRYLDWIYDNISTVDSASIVQLNRLLQGLLLIHSPSRSIFSNTTDMRKILRFVELGSPAVPFEVTISFITTLLHILIKNLDNFRVFESCNGCSILISKLKISDLSVPKKSIENNSSMKSANQQMLNFKIIEFLIFYLNDESESQGFDGKKKSIKEKSNYFRNDFPDIDNLIESLNDLKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B303</accession>
    <name>G3B303_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">chitin deacetylase</fullName>
            <ecNumber evidence="6">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_122093</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="6"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B303"/>
    <dbReference type="STRING" id="590646.G3B303"/>
    <dbReference type="GeneID" id="18248879"/>
    <dbReference type="KEGG" id="cten:18248879"/>
    <dbReference type="eggNOG" id="ENOG502QRIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030200_1_0_1"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="119"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="310" mass="34924" checksum="D9F8CB77E84F6CE7" modified="2011-11-16" version="1">MFVHPLLQLYQPQMKFLPLLVVIRAIAAAGLNLPFSLPPGITRLVGGPTLPFPQWLTDFTGLKEWPGLDPPFIPLDFIDFSKIEPANHHIQGQCDMITPTSCSFDCQNCVSFDDVYTCPVLSQTFDDGPTPATTKLLANLKTKTTFFVLGHNVAKYPDTYRQAVAAGHIMGSHTWSHKFLPSLSNEEIIAQIQWSIWAMNATGHHLPKWFRPPYGGLDNRVRSIVRQFGMQNVLWDYDTFDWKLNDNSKSAGQVVAEVDQLIKSRTHGLMLEHDMMVQTVNIGIDINKKLPSQMTVPQCIGGIDYIKRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B322</accession>
    <name>G3B322_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114095</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686375.1">
        <property type="nucleotide sequence ID" value="XM_006686312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B322"/>
    <dbReference type="GeneID" id="18247260"/>
    <dbReference type="KEGG" id="cten:18247260"/>
    <dbReference type="eggNOG" id="KOG2819">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559104_0_0_1"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="408" mass="46183" checksum="B5CD7BB7E8802BB1" modified="2011-11-16" version="1">MTQTIKPGEGLNALKINDGLYSVLDRFKHEQLNLMYSSKDYLNTPIRLQIKNWGMTLLFQKDKLTLIEIQSFSCGINYSYNNINLNSLGSGITLKVIYNKVFGPTYPGKFINNYYILSYPGVSFKFDLSAIQSNKGFDPSLAYLLNSDKDVVCGEIFIFNSNSFDEFLHSMKTGSAAATPASSELSSITEVSQTCDPSFKVSANIKLGVIRLSFRNKEFLVTIGKTTQQEVLNFLGPPDDYFNKFDSRLLIHSNFFKRISTSHTSNKILKFHNYFKFGVDFLYDLNGNGVLSKVILHNGNIVESSSFSHWNKCNYEIYLGNDSSDTNPFDSYDMRIGCSHYFDQIPADFFAGGSKTPILLNRSESELINLDVIPINESNDWGQSKLYCFDHCIWEVLSNDCVSCVTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3D9</accession>
    <name>G3B3D9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114171</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3D9"/>
    <dbReference type="GeneID" id="18247301"/>
    <dbReference type="KEGG" id="cten:18247301"/>
    <dbReference type="eggNOG" id="KOG1962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087648_1_0_1"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF19">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="174" mass="19785" checksum="ECC33A67A3A82F3A" modified="2011-11-16" version="1">MTLVFTSLCVQMAILFVMVLPLPHVFRRRIVSLIDVLRSSSNFKIGVGFYSLILAMQFADCLQRLQKLDYMKTPYFTMSNIPGGPVGLTNEQLASKFYSQRNLYISGAVLYLELAIYTVGTILKKLVLKEDRLRATNLTQKFGSEQEEEAKYKQLLTVKDQEIAKVKAELETST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3K3</accession>
    <name>G3B3K3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114238</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686488.1">
        <property type="nucleotide sequence ID" value="XM_006686425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3K3"/>
    <dbReference type="GeneID" id="18247328"/>
    <dbReference type="KEGG" id="cten:18247328"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="53"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="539" mass="60527" checksum="1C99651C705E19F2" modified="2011-11-16" version="1">MSKVSGTDFVPGTVHLVDIDGDLDVKKSMGSVILRPAPSSNPNDPLRWSKFKKLKQFFLLFWLATFLAITVNWSGPAWTLWTIEWNCTFDQLNISSALCFLFLGVGCLFLQPTAMKLGRRFVYLSCTVIMIVANIVGATCDNVQTYYVVNILAGFAAAPCDSLVEISTTDVFFQHERATYLSCFILALYVGSDVGPAISGFIIDTIGWRWCFWLQAIMFGCILVVEVFYMEDTTFRRDAGNDDSLENEILDQIKSRESKDPTGVHHHEVESDLQSIDETIPIRTYKERMTLYTTVYNDTRSWLCIFYRPFFMISFPAVIWGGVVYGAQMMWLSLLATTQSEIYSVSPYYFSASITGLTNFSPMVGSILGMMMGPVVDKVTIYLTKRNGGIMEPEFRLYMMVLPLITNAAGLVAYGIGSVSSSPWPVSVIVGQGFLGFAMSSSGTICLTYVIDCYHDMASEGLVLMLFMRNVIGMAFTFAIQPWLTRDGLKVTTWIMFALSVVINGSFLLMVLCGKSFRRWTANSYHKYSKPDFGELFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3K4</accession>
    <name>G3B3K4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbohydrate kinase FGGY C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_122459</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3K4"/>
    <dbReference type="STRING" id="590646.G3B3K4"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_10_3_1"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF1">
        <property type="entry name" value="PROTEIN MPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="1">
        <location>
            <begin position="266"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="513" mass="56169" checksum="3E24EA0A0B0A2A5D" modified="2011-11-16" version="1">MDLGVDIGTGSVRSFGDGFSAVRAITTTRHTSRVITQSSLEIFDAIQAVLPPTPVSGVCFAATCSMVVREKLVVDGRPVLAPFNCGTGASPGHQDIILWMDSRSHDQCATMNKQLEGSFMKQTIGEFIPELGLPKLKWLSDNSEKELYCFELYDWFSYVFQVGYYDKSQNLVEFALRDVDFTHGTAIDGSIKGWSREQLSFIGGNVKVGRSETVGPLDHVPSQLLPLGAPIGRAHPDLLADCHIFNGCIDCYGGWALTACPRQISMVAGTSTCFMFHTKAPAPLIPAVWGPFELVSQTAVYSFGQPATGKLFEDLFDEFSVGRDSFARMETITQEWELEHHQSIIELVRHYVYYGDKYGNRSPLSDFRMDECFIDGKNASVLGVSVFSQDEAAMVIRYHLIVEFLCFQTAQMLEPLPVDTIVVSGSQVNNTRLLRLLRHVTGKSVVILGGDHSLAVARGARGLCGSAGGESSHEAAAPLVAPPLSPQEASVMAAKFHVYKDLVAVQIKARRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3L7</accession>
    <name>G3B3L7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Bifunctional purine biosynthesis protein ADE17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_105647</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3L7"/>
    <dbReference type="STRING" id="590646.G3B3L7"/>
    <dbReference type="GeneID" id="18245829"/>
    <dbReference type="KEGG" id="cten:18245829"/>
    <dbReference type="eggNOG" id="KOG2555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_3_2_1"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="589" mass="64209" checksum="9CD58F0BBAA84F9A" modified="2011-11-16" version="1">MSYSKTAILSVYDKTGLLDLAKGLVAANVRILASGGTAKLVREAGFPVDDVSSITHAPEMLGGRVKTLHPAIHGGILARDLESDEHDLKLQGIEKVDFVVCNLYPFKETVSKVAVTIEEAVEEIDIGGVTLLRAAAKNHKRVTILSDASDYAGFLQELKSGEISAETRNRLALKAFEHTADYDVAISDFFRKQYSENVSQLPLRYGANPHQKPAQAFVSQGDLPFKVLAGSPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGLPLSDVEKKIYFVEDIENLSPLANAYARARGADRMSSFGDFIALSNIVDLPTAQIISKEVSDGVIAPGYEKEALAILKKKKGGKYCILQIDPNFTPDTLESRQVFGITLQQKRNDAIIKGSSFKEIVSTNKELTEQGIVDLTVATIALKYTQSNSVCYAKNGMVIGLGAGQQSRIHCTRLAGDKADNWWLRQHPRVLAFKWAKGVKRPEKSNAIDLFVTGQIPSTEPEKSDYESKFAELPEPLTAEEKQDWINKNKNVALSSDAFFPFPDNVYRAARSGVKFVAAPSGSVMDKAVFAAADSQDIVYVENPIRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3S8</accession>
    <name>G3B3S8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_105622</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3S8"/>
    <dbReference type="STRING" id="590646.G3B3S8"/>
    <dbReference type="eggNOG" id="ENOG502S5X6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365662_0_0_1"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="768" mass="87961" checksum="FD9522AB7E2121B6" modified="2011-11-16" version="1">MSLFSKLGPQGRALMGPTGSGSSFESYAGRKVEEGPQELDYLINDLRNSSQSMSVNKVLGYMYHYLPFVKVEHNLRLVFASFLNNPTCFTPGGASFESNYQIIEAFKAITDKKLSVSQPTIPVKTWYTVLFQELDHFVAYDIHRNSWKVLPILSGILLSNSLRDDLYSNPNMIEFGWFFGDWDSKAHDLFVKALGNTLAAYNSDDIINLSLLSLAVTYKRDQDITSYTPSVSVSFLITRLIQLIFANTSYSLQVYEKFFAFDINAANLHDTLNSEVMNKPVVKHLNRLSFLLESYYRVLPINKTGFDLIMDGLSKIKLFNASLCTRTQDSVFNHPNSIKDQSVLHQQFWFFMKNIFFSECIIVQGIMTRFLSVNQSKGFSIFSIFKETYNIESEYRFIALKVVESFYHLNHILVNIGQGGFDSFNFVYYLSLELIFGAQPSIVELEKLSMFLLGYPNVNLNADVINFNPINRGRVLFVMGLWENYLQKNSFNNDYIKRNIFPICFDVVNNRGIQAYEIIEAAHSVLLLCFSNKRVNKNLKELMEYIELIVNQFPRILSAQQLSIAVESLGKQILSNPMVYEGSMYANSADEFLEFINFKCLNTKSGIPISIKASDSMFTSAQPIGEIHAESTMKSLETKKQNINIVAENKIKKPKDLVPLGMLPEATVAPTEYNFAKRLVPETSREAMVLSFVNLVPYLPLSVFLRWLEKIFFVIESSNHSEKTYLISMFWKVLSENLDLNRCELAYRWWYETKKAVAKNIGQEVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3T7</accession>
    <name>G3B3T7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_134312</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686043.1">
        <property type="nucleotide sequence ID" value="XM_006685980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3T7"/>
    <dbReference type="STRING" id="590646.G3B3T7"/>
    <dbReference type="GeneID" id="18249788"/>
    <dbReference type="KEGG" id="cten:18249788"/>
    <dbReference type="eggNOG" id="ENOG502R4NW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446963_0_0_1"/>
    <dbReference type="OrthoDB" id="3976101at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="63349" checksum="23AA52B40A6EC3F5" modified="2011-11-16" version="1">MLTQLSPVILDRVLEYVDPTSLVNLACTNYQFYSPCLAKLYREIVVFSTCSLVPKTHRKLSFNDKTVICGLSQCHDTVKNLKMVEVRLSALNSALSINSDLPNLVKKVSVFDTFNQAVDNEIVQLLGKISANVYVENDKLRKYLKSKISFNSIIVDHVSDFKDIDELDIRTGHCEQKQLFFSKKRSYVIQNPSFFSYLKKNSLKIFPTSINIDRNTELSVIDMQHLKNLEVSLDPHTNLDFITKSIDLYRLQKLSIVQPDLYDHNRNEKTDLKLIEWLSLHANEFRSLSYLSISYNPPLTGQIVDEFEGNYLKKIEVLETLVNVINTLATPKINLVLPNYLEVLSCYEQPMNNLMWNGCKCGYCSVWLEKLDDFVNFHKYFDESSNYWKDLNNAITLNSLAQNYRCRYLARNNFDMCGSVRFQNWDFHTNHFAPIQFQCCSLQTVYESEYNDGREIYFDTSSTQAPCQYRQLFIHLDICMVHYLQGIVNKLVRLDRGNAESFEITDGDINDGDEPINLQNLYVSGFRFAFDKEMNGTNFYESYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3T8</accession>
    <name>G3B3T8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113768</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3T8"/>
    <dbReference type="HOGENOM" id="CLU_2359497_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="96" mass="10544" checksum="FB76FCC3E7637AA4" modified="2011-11-16" version="1">MSTVMHAASCTFTQELCGGWCRNRKFPLPFGGNPIPPIHCLGLQSYISTFTDSPIIYIINPSTFQLTSPIVFSLPSLPSLGSRFYSSIDLKEKGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3V1</accession>
    <name>G3B3V1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_105348</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3V1"/>
    <dbReference type="STRING" id="590646.G3B3V1"/>
    <dbReference type="MEROPS" id="C19.088"/>
    <dbReference type="GeneID" id="18245804"/>
    <dbReference type="KEGG" id="cten:18245804"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016013_0_0_1"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="220" mass="25439" checksum="C122E06C43C676ED" modified="2011-11-16" version="1">MSLMSRLQEDSTPKGVKLNKSIIYDIFGGLLNQTVVCERCHNKSTTKQEFYDLSLGFKKRKQSKYSISRSLKDFFSQELIKTDNQDKESGYFCEKCRLNTNALKHSTVDIAPEYLTVHLKRFKFNGSQSMKVKQSMKYSNYLDMTDYTTKKSPTVYQLISIISHEGRSLSSGHYISHCLQPDKSWYTYDDEYINKISEIQALNDPSAYVLIYSKMTPKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B400</accession>
    <name>G3B400_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_134482</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686215.1">
        <property type="nucleotide sequence ID" value="XM_006686152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B400"/>
    <dbReference type="STRING" id="590646.G3B400"/>
    <dbReference type="GeneID" id="18249796"/>
    <dbReference type="KEGG" id="cten:18249796"/>
    <dbReference type="eggNOG" id="ENOG502RFPT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_0_1"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF68">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33326" checksum="8A92A34CE46A7574" modified="2011-11-16" version="1">MSLPQKGVYTPVPTFFKKDLNTIDFATQVAHAKFLQDNGIKGITLLGSTGENAHLTRAERAEIVKQIHDNVKGFTIVAGIAQNCLQETIEEIESVAKSGASFALVLPSSYFGPSITQEALVEWYTEVADNSPIPVLIYVYPGVTNNVNVAPSTIKTLSSHKNIVGIKFSHNDVTSYSEISLDEEIKDFVCLTGLGHLLLPALSIGFKGTVDAISGAYPKIYTRLIQAFDEGNFKEAQRLQLAIIRGEKCVSEYGVIGIKRIIYEATGFGETYLGRMPLNKDTTAGWEKLDKFIAEISEGEKSVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B410</accession>
    <name>G3B410_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_97930</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B410"/>
    <dbReference type="STRING" id="590646.G3B410"/>
    <dbReference type="GeneID" id="18250728"/>
    <dbReference type="KEGG" id="cten:18250728"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="99"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="200"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="288" mass="31625" checksum="B30E41AF3AB5EF6F" modified="2011-11-16" version="1">MSASTQKVKYPFWYGGASSMVACLVTHPLDLAKVRLQTASKPGQSLVSMVYQIITKEGFFKIYSGLTASLLRQATYSTVRFGVYEYLKDSYVDTYHRTPDTVVLLPMSMVAGALGGLVGNPSDVVNIRMQNDSTLPVEQRRNYRNAFDGVFRIVKEEKISALFRGLMPNLTRGILMTASQVVTYDIAKNILVKDIGMDANKKSTHFSSSLLAGLVATTACSPADVVKTRIMNAKGGGSNALTILKTAVKNEGIGFMFRGWLPSFIRLGPHTIVTFLALEQLRKFKIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B421</accession>
    <name>G3B421_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_130165</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B421"/>
    <dbReference type="GeneID" id="18249426"/>
    <dbReference type="KEGG" id="cten:18249426"/>
    <dbReference type="eggNOG" id="ENOG502S2DU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="41"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="380" mass="42434" checksum="40738FAF8EE80B14" modified="2011-11-16" version="1">MEAPLFYDKVLGQQWVAVKDDNGYSIKKTKISIPSSVSEPPQLENLTIIDSVKSGTGRDGKASIYHHIIKPTLDHLKVPHNYVVTTSGDTIGAFSRQLTQGTHKIVLISGDTSVNELINSLSSDQHGQIRLVVIPLGTGNSLSLALGISNELEAVKRLVTSNEFKPLNLYTIKFPEDPSYVLHEGTQVRPAPSEMKFLVVFSWGFHASLVADSDTAEMRKFGLERFKMAAMSNLEAPQHYEGTTKISSDKDTREVAGPYAYWVLTPSRRFEPTFEISPSGNIFNDEMYLVSFGPRDTDQTPYIMEIMTQAYNGGAHIHNGSVSYEQVDSTHQVRLKYHQDQENRRRFCVDGAVILAPPSGEFRVRACGHKQQKWEIFVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4H4</accession>
    <name>G3B4H4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_105099</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ribosomal function.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4H4"/>
    <dbReference type="STRING" id="590646.G3B4H4"/>
    <dbReference type="GeneID" id="18245779"/>
    <dbReference type="KEGG" id="cten:18245779"/>
    <dbReference type="eggNOG" id="KOG1486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="65"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="292"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40802" checksum="7440784D4D884671" modified="2011-11-16" version="1">MGVLEKIAQIQDEMARTQKNKATEYHLGLLKGKLAKLRRELLEPQPGQGSGGGGQGFEIAKAGDARVSLIGFPSVGKSSFLSKVTNTKSEAANYEFTTLTSVGGLLHYNGAEIQIVDLPGIIKAAAQGKGRGRQVIAVGRTSDLILMVLDSTRGDEQRKILENELETMGIRLNKEKPNISLKIKSSGGVKMNSINPPVHLNEKIVSGLLKEYKIHNADVLIKDENVTIDDFIDIINESHVTYIKCLYVYNKIDVTSLEECDRLARQPNTVVMSCEIDLGIEDLKEEIWRQLGLIRLYTKRRGIAPNFNDPMVVRNNSSIQSVCDAIHRDMRNQFKFALVWGSSSKHSPQKCGLTHIVHDEDVVQIVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4I6</accession>
    <name>G3B4I6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_97874</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686153.1">
        <property type="nucleotide sequence ID" value="XM_006686090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4I6"/>
    <dbReference type="STRING" id="590646.G3B4I6"/>
    <dbReference type="GeneID" id="18250720"/>
    <dbReference type="KEGG" id="cten:18250720"/>
    <dbReference type="eggNOG" id="ENOG502S3SU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040397_0_1_1"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="280" mass="30974" checksum="48B86FE9B0917234" modified="2011-11-16" version="1">MVFQFNIDKHTKDFVPPNQVKRLPRALGYFLGNNDNGSKQRPDYFIWLEVLIGSFCGILVLEGVFRNPNIFTDHHNAPIVIASYGATAILCFNTNGLPLAQPRNIILGHFSSALIGVCVEKLFSLSEKGRDHYYIGGALSVGMASVLMSILNCVHPPAGASALLPFIDDGIRDMSWWYLPTHLVSSVLIVAVALITGNVIRKYPAFWWTPLNRTPPPPTQEPKEEKALETLVLNAETLQVPKSLSLSEVEMEVLESLQNKLRDYKPNTDSIGSTDIGQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4S0</accession>
    <name>G3B4S0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113882</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686578.1">
        <property type="nucleotide sequence ID" value="XM_006686515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4S0"/>
    <dbReference type="STRING" id="590646.G3B4S0"/>
    <dbReference type="GeneID" id="18247161"/>
    <dbReference type="KEGG" id="cten:18247161"/>
    <dbReference type="eggNOG" id="KOG1681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_1"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="268" mass="29820" checksum="86962A92DD3C8964" modified="2011-11-16" version="1">MPFSSENYQHPEFIVKEIEEGFINLQFNNPKTLNAFAESTWRGYQELLEKLDKDPDTNIILISSSIEKSFSSGLNLKDAAILTQLAEDDSLSYRQKYDTLYKHIIEFQEAISTPARIRTPTICLLNGISYGLAMDIAATCSIRVAVEGVKMSIREIKIGIVADMGSLQRLPFLVNNKSKLNQYALTGEIFGAQEAYDIGLVSKVCADLKSGYEYCHELGSDINQNAQWAIKGTKDSLQFINNGGNVSTGLLDIADYNAIHITKIPSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4W4</accession>
    <name>G3B4W4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Urea active transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_121979</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4W4"/>
    <dbReference type="STRING" id="590646.G3B4W4"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="71481" checksum="262695D06943A50A" modified="2011-11-16" version="1">MEPVLTQAYGYGFAVGLGAAFALLMGFITRVLSKYLGQTQNSERFSTASRSVKSGLIASSTVSAWTWPATLLSSGAWSYSHGISGGFLYGIGGTFQITLFLFLAIQLKKKAPSAHTVSECFYIRFGKAGHWCFLVYCISNNVISAACMLLGGSQGFAATTGMHVVAASFLLPMNVVAYTALGGLKATFVSDWIHTVIIFGVLLATCYTIYCSSPLIGSPGKMYDLLQEVQAVFPSETGQSYLSFHDKSMILLAWSVAIGALSSVFGDPGYSQRAIAADSSSVFEGYLMGGLCWYIIPFALGSSGGLATRALLTNPKSVTYPNALTQEEVNSGLPVIYAMTSLWGKSGAAAGLVTLFMSVTSSTSAELIAFSSVSTYDIYRTYINPNASGKQLVRMAHMTVCGFGLFTAVLATVFNYIGVTVGWLISFLGIILTPSVSAVTYTLFWPKMTKLSLVIGCPLATLTGIAAWIAGTYCYSNGIIDKDTLNGSTATFIGNISALMSAAIYIPVISFIKLDKEPFDMSKLNSEMTVGDDVDKEGKEALIVTESIDKLLNRQSFLTILINIFLFFGIYIVLCVSLYGIKKDFSKSSFVGLMIVMLIWLVVAAAYIIVYPLWQGRFSIAKLVRLMLGMDHMVEEKSEVEDLSQGGSLSEAPDSVVEVVYSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4W9</accession>
    <name>G3B4W9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114035</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686322.1">
        <property type="nucleotide sequence ID" value="XM_006686259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4W9"/>
    <dbReference type="STRING" id="590646.G3B4W9"/>
    <dbReference type="GeneID" id="18247225"/>
    <dbReference type="KEGG" id="cten:18247225"/>
    <dbReference type="eggNOG" id="ENOG502SEBV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137871_0_0_1"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="244" mass="27704" checksum="DAE9F70D42076730" modified="2011-11-16" version="1">MNDSTANMSAFHTPLKRLPDRPINLELESKLQREPPCKAVPEVSPQEELKPLNEIAIQLSKTKLTNKQNDLFSRSSSKKSVYYKPPSSSNIDNQFGIKSFLPPIIKRNYPLMATPTPEQQDLDTEQTSIPTGEWENPVIQQALGRQVNRAVEIKRISTGVVVILWIQLVKKVVSVNILHYPVSVIVLAQVLVILRCVYRLFKLKDQCVDLPLNNKQRVLLGLDTLDEDVDVKVEKARYSQFGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G3B530</accession>
    <name>G3B530_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_93894</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686916.1">
        <property type="nucleotide sequence ID" value="XM_006686853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B530"/>
    <dbReference type="GeneID" id="18250338"/>
    <dbReference type="KEGG" id="cten:18250338"/>
    <dbReference type="HOGENOM" id="CLU_2305735_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="100" mass="11262" checksum="858C92C209C7FF16" modified="2011-11-16" version="1">MALKNYLYAKHARDEFTLSLMQKANIIIPQNLQPLGAGSGNEEKAKSHCSDIESCNNCANCPNKKNTPKITIEIDRDTKLEQEIESINHTLTEIDFTNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5C9</accession>
    <name>G3B5C9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114507</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5C9"/>
    <dbReference type="STRING" id="590646.G3B5C9"/>
    <dbReference type="eggNOG" id="KOG0933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_8_1_1"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="1">
        <location>
            <begin position="81"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="168" mass="18691" checksum="4B8735DDA8A82AA3" modified="2011-11-16" version="1">MIRTIEKDKSKIINTIEKLNGYKRDTLNSTYAKVSVDFGNIFSDLLPGSFAKLVPLNAEDVTKGLEVKVKLGQVWKESLVELSGGQRSLIALSLIMALLQFKPAPMYILDEVDAALDLSHTQNIGHLIKTRFKGSQFIVVSLKEGMFTNANRVFRTRFQDGTSVVSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5D2</accession>
    <name>G3B5D2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPI inositol-deacylase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_106479</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5D2"/>
    <dbReference type="STRING" id="590646.G3B5D2"/>
    <dbReference type="GeneID" id="18245892"/>
    <dbReference type="KEGG" id="cten:18245892"/>
    <dbReference type="eggNOG" id="ENOG502QQNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015737_1_2_1"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="2">
        <location>
            <begin position="114"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="328" mass="37370" checksum="44A44E5CAF55CA57" modified="2011-11-16" version="1">MLLRFLHHPSKVSTLSIRWLQSAAIKDPFLLTDQFAALKPNYTPTKHPIVLCHGLSGFDSLVFLPKPNFFRKSRVKKVIRDGLIKVDYWYGIQDMLTRNGCEVYVGKVPPFGTIHDRAESLNKYLESQFEPNDSETTVVNLVAHSMGGLDARYLISKLHKSNYRVASLTTVSTPHRGSEVADYVSVHMKPALLLFQAVPQLTTDYISKFNSEVVNDPNVAYFSYGAQFQPKWFNMFRYPSRIITKTIKSQNILNGTDKSYVNDGLVSVESAKWGEYLGTLDNVDHLDLINWTNRARILVDRVMFQHKPTFNALAFYAHIAQSLSERGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5G8</accession>
    <name>G3B5G8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_105888</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687015.1">
        <property type="nucleotide sequence ID" value="XM_006686952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5G8"/>
    <dbReference type="STRING" id="590646.G3B5G8"/>
    <dbReference type="GeneID" id="18245848"/>
    <dbReference type="KEGG" id="cten:18245848"/>
    <dbReference type="eggNOG" id="KOG4066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065847_1_1_1"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="196" mass="22158" checksum="E13DE669B9F5B20F" modified="2011-11-16" version="1">MVFEKVVFPSYPHKTVFISVFANVPKNVLSVVKTKLIEGDPNYELCFLNTNYIISTEYLYSAIYKAILNFETGQSKAKTLNTEIIFNLSPVNNIMDAFKRFGVDDSQDQSNVICIKVIDYVSDGNCLEDLNTHISKLLHTDASQNIPLQDAYLFKTVDISKFKKIFKLNDAKLSESENLQIQLTRLAIGACLIRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5N0</accession>
    <name>G3B5N0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114563</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5N0"/>
    <dbReference type="STRING" id="590646.G3B5N0"/>
    <dbReference type="GeneID" id="18247477"/>
    <dbReference type="KEGG" id="cten:18247477"/>
    <dbReference type="eggNOG" id="ENOG502SBKE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022609_0_0_1"/>
    <dbReference type="OrthoDB" id="5370852at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031990">
        <property type="term" value="P:mRNA export from nucleus in response to heat stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034432">
        <property type="entry name" value="Nup60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28284">
        <property type="entry name" value="NUCLEOPORIN NUP60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28284:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="522" mass="56252" checksum="B16C13FCB753DA5E" modified="2011-11-16" version="1">MDNRRVYKKQTNAKEKRRNLLSKVGILVSSMWKKADSFPDNSVPLPPSTPTPTPKAFGEDASIIVTPNNTQLDFAPSLNKTPNVLLSEFFSQKGNKPLTPIEYQGVMSLLSQSQGKSNNGIISPKMPGSFTRYDSPSRLKLPEKSNKERSLIESTPSQQSVLKNTSNTRGLSPQTFATPEYKHKLHGTTESAISSVKRSAPSIKRVYQFSGLPSPYRTKIKAPVLSSNKKVHQFDTNHMDSLIEKSSRDVGKPLNKTASSLLSVLDNNKRNQNTYLHQFSNPYMGKSAIAKRQHNLTADVINSSIMFDQSTDLPDTVSNNSSITTPAAETASAANTNVNNLSINAAAQAIIPTDKASSTYSVSFPTSVSAHPQVSAIKNGNLFNNSSVSATTPSLSSGGNPNASNGSSDSSTKEPQILDAHESNTNTNSNSSSSGPSQAFDSTSLKYLGSLEQSPKKEYRQSSSSISANVILPDASVPPLNLSSSGLASNGGPFNFPQLELVAVELDSVKVSNYKYLFSFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5S0</accession>
    <name>G3B5S0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114588</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687408.1">
        <property type="nucleotide sequence ID" value="XM_006687345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5S0"/>
    <dbReference type="STRING" id="590646.G3B5S0"/>
    <dbReference type="GeneID" id="18247490"/>
    <dbReference type="KEGG" id="cten:18247490"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_785260_0_0_1"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="237"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="353" mass="40281" checksum="6B12F504D2E9226F" modified="2011-11-16" version="1">MAFKLNDYNAFLTSLVEREKSDTSRPESKNMTETLNSPTDDIALMDQQDPMNSTYSRLPIDFDFGLNQEIDFSDDLDPQSTMNLNMNDDNDLSKRSYNPSSKLTNNASTTSTNRASSNSTNNTSDMDPPLKQEDIFFPRQASAPALESNFESVPSSSNYRIPIQIKNESSDDELMSPNLDLPDGFCDNFDNINTLDRQHSNTPTDDFSRRRDSRPLVQKSGGEGLGYGSMTKSYRPRLRSSHNVIEQRYRNKINDKFNALSNSVPTLRVATKRKTKNPDHMDNDEFDEHYYSSSDESPDLEGLEPARKLNKGVILSKSVEYIRFLELKNDRMREKNHELLEKARLLGIPLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5U7</accession>
    <name>G3B5U7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_130800</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5U7"/>
    <dbReference type="STRING" id="590646.G3B5U7"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005350_12_2_1"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="123"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="503" mass="58272" checksum="5BAB28CAC4144172" modified="2011-11-16" version="1">MHQRSESNYSNNYSLLDMYKEDSEDEQNTLNTSKLDSINQQTTKEILNGDFDRYGFKKVSVHSSITNETYNDWFKEYAEFLKERKTKWVMLLKSNGLQVDSEKTIPSRFPPKSDKVKKLIRKGIPGEWRGSAWFFYAGGYEKLNKHVGVYDKIVRDTKNLQNKDTDVIERDLNRTFPDNIYFNGSLRSNQDGTPGKQKPQSQEEEKNSSPMIRSLRRVLVAFAHYQPQIGYCQSLNFLAGLLLLFMSEERSFWLLVILTERIIPKVHSKNLEGVHTDQGVLMLCIKEYIPSLWSILGKTFEGEVLSEDKILTKLPPVTLVTSSWFMSVFVGVLPIESVLRIWDILWYEGSKTIFRFALTLCKTCLESEEFQNAKPRKKNTELEQVELFQFMQSFPKTLINPNVLVDNCFKKIGGYGYGSISQDEINKCREFVAKQRQKLKNKSNSVINPEMNAQERRLLTGDDDIHDVYGFNRSIMSGVAWNNNISNKMKKRFSRKASKSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5X9</accession>
    <name>G3B5X9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase M18, aminopeptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114626</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687429.1">
        <property type="nucleotide sequence ID" value="XM_006687366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5X9"/>
    <dbReference type="STRING" id="590646.G3B5X9"/>
    <dbReference type="MEROPS" id="M18.001"/>
    <dbReference type="GeneID" id="18247514"/>
    <dbReference type="KEGG" id="cten:18247514"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019532_3_1_1"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="509" mass="55322" checksum="5813CBCA54ED5862" modified="2011-11-16" version="1">MSEFNEMVRALKATLDQLEQKEIKSQSDFQSRVTSNNAASTPVKSMDFAAVSQKYIDFTYENPTIYHVVSHFSGKLEDNGFTYLSEKKTWSDLKPGRYYTARNGSSLIAFVVGPDWTAKRGVGAIGSHIDALTVALKPNSTKSKVDGYELLGVANYAGTLSDSWWDRDLGVGGRLLIRKDGKLVTQLVDSSPNPIAHIPTLAPHFGTPAVGPFNKETQAVPVIGYSSEDDEPPTEEEKSAPLYGKHSLNVLRYVAKLGGVKVSDIYQTDLQLYDVQKGSFGGLNKEFIYSPRIDDRICSYAAIEALVDAANGGELPDDGFSLVGLFDHEEIGSATRTGIKGGLVESTVARVLASEYYASATPVEEDIRLAYANTIILSADVSHLLNPNFSSVYLEHHKPLPNTGLALALDPNGHMATDSTGVALAEELARINGDKLQYFQIRNDSRSGGTIGPSISLQTGARTIDLGIPQLSMHSIRAATGARDLGLGIKFFTGFFINWRTVYDTYSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3B625</accession>
    <name>G3B625_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRM8</name>
        <name evidence="13" type="ORF">CANTEDRAFT_130840</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B625"/>
    <dbReference type="STRING" id="590646.G3B625"/>
    <dbReference type="eggNOG" id="KOG3115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_3_1_1"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="252"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="278" mass="32956" checksum="0817A23F2EFB14BD" modified="2011-11-16" version="1">MAEPDTKAQKEQQLEADSKRKTYRERKEVIRKNAKELDLPRKRYYRQRAHSNPFSDHRLDYPKYPESMDWGKFYPAYHDKETNQMTQDVEIADIGCGYGGLLLGLTKEFPDKLLLGMEIRVQVSQYVEDRIIALREKHKKQKVNYQNIAVIRGNAMKFLPNFFKKGQLSKMFFCFPDPHFKQRKHKARIITNTLLSEYAYALREGGIIYTITDVEDLHKWMVEHLEDHPLFERLDKEWEAQDKCVEIMYNATEEGQKVARNKGSKWVACYKRLPTPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6L1</accession>
    <name>G3B6L1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114798</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6L1"/>
    <dbReference type="STRING" id="590646.G3B6L1"/>
    <dbReference type="GeneID" id="18247584"/>
    <dbReference type="KEGG" id="cten:18247584"/>
    <dbReference type="eggNOG" id="KOG1597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_1_0_1"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000036">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="11">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="344" mass="37806" checksum="E8A7FA6BB3FA1BD9" modified="2011-11-16" version="1">MSVKTATAVDEPFTGPNLNITLVCPDCKIYPPDLIERFSEGDIVCGSCGLVLSDRVVDTRSEWRTFSNDDQNGDDPSRVGDAGNPLLDHENLSTMISHSPDSLRIGRELSRAQSKSLVDKKDNALAAAFAKISQMCDGYQLPKIVQDAAKEVYKLVYEERPLRGKSQESIMAASIFIGCRKAKVPRTFKEIWALTNVPRTEIGKVFKIMDRIIREKNAINPAAFSLVEDNIQTTQTSAEDLIRRYCSHLGLGTQITNAAEYIARRCKELGVLAGRSPTTIAATVIYMANVIFGADLQPSKIADKTGVSEGTIKTSYRVITEQKDELTNPAWTLPSSDVQGNTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Q0</accession>
    <name>G3B6Q0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_105839</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Q0"/>
    <dbReference type="STRING" id="590646.G3B6Q0"/>
    <dbReference type="eggNOG" id="KOG1612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046570_1_0_1"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="30"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="286" mass="31739" checksum="AD977C2F2DF9BCEB" modified="2011-11-16" version="1">MLLSPAERQYLYDSLVQNPPIRPDARNVFQCRPLEATTTFLPSSNGSARLRMTDGAECIVSVKSKVVKTADTPNLLEVDVDVQGYRDDSNFVATLKYNLSSLLHKNFPFEALKLTSRYSYKLFIDCIVMSNTSYPLTIISMAIYLALKTTKLPKLVSEVDDVNVEEQPTFSDDWEDAKTLGEATGSDFQPPVFITLGVIGSSLLFDPSLEEEQVLENGLIVSFYDGKAQTPLQNINLALNSNKNNYKGLKSTHIVSAISMVNKYCGMIIHALDTLIDQDEGDGQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Q7</accession>
    <name>G3B6Q7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114306</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Q7"/>
    <dbReference type="STRING" id="590646.G3B6Q7"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF157">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="334" mass="37921" checksum="077D72176A33145E" modified="2011-11-16" version="1">MNFEVSYPSVERPFGVHLWPIFDYAFERVVGYPATQFEFLHNQTFLANGYHAVGVIIVYYLVIFGGRFVMTTLDVPALKLNLLFQLHNLVLTAGSGILLLLSIEQVLPIIVKDGIFGAICYETAFTQKLVTLYYLNYLTKYLELVDTVFLVLKRKKLLFLHVYHHGATALLCYTQLVGYTAVEWVPITLNLTVHVVMYWYYFLSARGIRVWWKEWVTRIQIVQFVIDLVFIYFATYTHFAFAYFPNVPQYGKDCYGSEVAAVYGVLIITSYLLLFISFYFSVYRGKSKKVATAIATASATNDVKPTATTSGSTTGSTTGSTAKKHVTKSKSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6W1</accession>
    <name>G3B6W1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_106351</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686829.1">
        <property type="nucleotide sequence ID" value="XM_006686766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6W1"/>
    <dbReference type="GeneID" id="18245881"/>
    <dbReference type="KEGG" id="cten:18245881"/>
    <dbReference type="eggNOG" id="ENOG502T178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199938_0_0_1"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="83" mass="9351" checksum="53193AB3DB5C2825" modified="2011-11-16" version="1">MSYPDYIDGEPPVVGMIQYDQAAWAGTTSIDRQDGVYVIVETAEPTKIVAKVDPKDTLMLDMIFQDAHKEYAKQINDKNVQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B707</accession>
    <name>G3B707_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114378</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B707"/>
    <dbReference type="STRING" id="590646.G3B707"/>
    <dbReference type="GeneID" id="18247397"/>
    <dbReference type="KEGG" id="cten:18247397"/>
    <dbReference type="eggNOG" id="KOG0991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_0_1_1"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:DNA replication factor C complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA clamp loader activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="43"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="325" mass="36338" checksum="9FA172DA4BD9652F" modified="2011-11-16" version="1">MTKESPLTLELPWVEKYRPHKLDNIVGNEETVERLKLIANDGNMPHMIISGLPGIGKTTSIHCLALELLGPELYKSATLELNASDDRGIDVVRNRIKQFAQTKIQLPPGRHKIIILDEADSMTPGAQQALRRTMEIYSNTTRFAFACNQSSKIIEPLQSRCAILRYNKLADDQVLTRLLEVCKLENVQFNTEGLQALIFTAEGDMRQAINNLQSTVAGFGMVNDVNVFKIVDQPHPLVIRKMLRSCCSSQDIDNAIDLLDGLWVKGYSAIDIVTSAFKVAKTLPDINESKRLEVIKEIGFTHMRVLEGVSTYLQLCGMLAKICDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7A9</accession>
    <name>G3B7A9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Damage-regulated import facilitator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115067</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7A9"/>
    <dbReference type="eggNOG" id="ENOG502SG7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132208_0_0_1"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="127" mass="14061" checksum="B622B5FE3625DA0E" modified="2011-11-16" version="1">MNDYKRIMTHPAPAGKSEEENTLATLGMRIRKSIADGYSGPSHSSYSYKGNANVKRQPLPSHVSQPPALSNSSSTFDSSSSLSEWDSSFSSVLQTIPQVSSNKRRMEDSENSYIHPVYGVLRTDEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7H8</accession>
    <name>G3B7H8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115744</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7H8"/>
    <dbReference type="STRING" id="590646.G3B7H8"/>
    <dbReference type="GeneID" id="18247997"/>
    <dbReference type="KEGG" id="cten:18247997"/>
    <dbReference type="eggNOG" id="KOG1753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="142" mass="15810" checksum="55917158C2897EDB" modified="2011-11-16" version="1">MSTPSVQTFGKKKTATAVAHIKAGKGLIKVNGSPITLVEPEILRFKVYEPLTLVGLDKYQNLDIRIKVSGGGHVSQVYAIRQAIAKGLIAYHQKYVDEASKNELKKIFTAYDKTLLVADSRRMEPKKFGGRGARARFQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7L0</accession>
    <name>G3B7L0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_98831</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688765.1">
        <property type="nucleotide sequence ID" value="XM_006688702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7L0"/>
    <dbReference type="STRING" id="590646.G3B7L0"/>
    <dbReference type="GeneID" id="18250808"/>
    <dbReference type="KEGG" id="cten:18250808"/>
    <dbReference type="eggNOG" id="ENOG502SBH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160156_0_0_1"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="123" mass="14325" checksum="4EFB4216DF080FA8" modified="2011-11-16" version="1">MAPPTPVYDRFDILTRYGEKLDNPDKYQCSLKSLVQSECTFKLSNPGLPPEVICLPFKRLFQRCLVPTTIVQDGKRIKADKWVNIEVTHEHTNRGLFHDPKYDSNVKKFLQAEKDLSRMLQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Y3</accession>
    <name>G3B7Y3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DnaJ-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_108904</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687856.1">
        <property type="nucleotide sequence ID" value="XM_006687793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Y3"/>
    <dbReference type="STRING" id="590646.G3B7Y3"/>
    <dbReference type="GeneID" id="18246070"/>
    <dbReference type="KEGG" id="cten:18246070"/>
    <dbReference type="eggNOG" id="KOG0717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009539_2_1_1"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000046">
        <property type="entry name" value="dnaJ homolog subfamily C member 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="64503" checksum="982F2D1234833418" modified="2011-11-16" version="1">MKTDYYELLDVAIDASDTELKKAYRRKALQLHPDKNPDDIEGATARFALVRAAYEVLSDPQERSWYDSHKGSILNDDKVVETENDELVIPSISVEELYRYFNPSFYSQINDSQNGFFYVVASLFGRLASEEINHGRHQKFPEYERYQDNSPNVSALDDSVLMYPKFGNSGTDYATNIRSFYNVWSSFQTVKTFSWKDEYRLSSAPDRKTRRLMEKENKKFREAARKEYNETIRNFVQFIKKRDPRVKKGIQELEKEKKRKKKEEIDNQIKLNKQQRLKALSQSNNFEVQDWQKFSVEELDELEGMLNEEYKSSSDSEFDEFEQVDDIEVFECIVCDKVFKNEKQYQIHEDSKNHRKAVNKLKYEMRKEGVELGIDEQFETASEHNSESEDEEASHEEFPVVSDTSETNLENQSVDPLVFEVDDSIESDDYSEDLSSSQPQKTKVKGKNKKSSSILNLEDELSKITGLASGINLDSDEDDWSNSGKKPKKRTKKAEKKGTYTPSLPGASSPSPSPSQSTAKGSESCATCNNSFSSRNKLFQHVKETGHAAPVNKVKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B807</accession>
    <name>G3B807_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_115786</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the bZIP family. GCN4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B807"/>
    <dbReference type="STRING" id="590646.G3B807"/>
    <dbReference type="GeneID" id="18248016"/>
    <dbReference type="KEGG" id="cten:18248016"/>
    <dbReference type="eggNOG" id="KOG0837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068501_1_0_1"/>
    <dbReference type="OrthoDB" id="5419235at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12192">
        <property type="entry name" value="GCN4_cent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001491">
        <property type="entry name" value="Cross-pathway control protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="251" mass="28211" checksum="A8785136E5ED5424" modified="2011-11-16" version="1">MSKMFSPVILNDTFIGSNPVEGSNEKEMNKVPKLATDESAPGLSAPDSSLAFHSEVLDSVFSNDEAVDHTPMFDELDFMLESSNKEDWVSLFDANNEIDNSFNFTKVVSDEDLSIPFEKEVSASPDKEFVDLGRYDRKRAFSQMLTPSTSSTLSTPNLDLPRNEKLDHLGVVKYSKKSRTQPLGPVKVGSNDPVLMKRAKNTEAARRSRARKMERMSQLEEKVEGLIDENSNLSSEVLRLKELLDLHDIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8N5</accession>
    <name>G3B8N5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">superoxide dismutase</fullName>
            <ecNumber evidence="5">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_108128</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8N5"/>
    <dbReference type="STRING" id="590646.G3B8N5"/>
    <dbReference type="GeneID" id="18246005"/>
    <dbReference type="KEGG" id="cten:18246005"/>
    <dbReference type="eggNOG" id="ENOG502S5NX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063073_2_0_1"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442804" description="superoxide dismutase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="18">
        <location>
            <begin position="47"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV61775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="299" mass="32335" checksum="684AC38D5560C11A" modified="2011-11-16" version="1">MRFQKPILLALAAALVTAGEAPKIKKNPADVVAVADFPSGGPQKILGNVVFTAKKGKAVNVYIDVTKLPKEGGPFQYHIHQQPIGANGDCEASGTHLNPYKASPDCDSQKTDAFCQVGDLSGKHGWIDTTCFETKYDDPYLSLNTKSKSNIIGKAIVFHFANLTKFACANIEVAGDVRLKSLEEEYSRNGNDDLNELKSFVANDYQFVPGQEVFEVAEAHSKRDLGVSQYAEIDEDDNDDDTEQTGDVPDCTNSTHHHSGSNYSNFTNLSTIDCENNADSLGWAAIPAILSGVAAVFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8R6</accession>
    <name>G3B8R6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115875</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8R6"/>
    <dbReference type="STRING" id="590646.G3B8R6"/>
    <dbReference type="eggNOG" id="ENOG502RXJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056749_0_0_1"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33449" checksum="91A1F27E0EFAF49F" modified="2011-11-16" version="1">MPSQIAHKHHDEIDDKGFTLLKGFLTPEEVETYKESARKVVELARKGDWSEVRTRGKQFPPWPKNFSPDIWGISGLLNPKLGDLSLPFQECYSSSKMLDVVCDILQTNQESLSMELFNMLINPLTDFGLDWHRDHIKPEATEEEEREELQANPFAGAQFNLALTDDECLIVVPGSHKRVRTSEEREKTIPKDRQQHISGQITVKLSPGDMVFYNSNILHRAQYSAASERLTLHGSYGHKDFGKFRAKGVLQHGVASWIHEFKPINSNLEMLWKKLVALSEEFKAEELGYSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8X0</accession>
    <name>G3B8X0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_107809</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687967.1">
        <property type="nucleotide sequence ID" value="XM_006687904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8X0"/>
    <dbReference type="GeneID" id="18245982"/>
    <dbReference type="KEGG" id="cten:18245982"/>
    <dbReference type="eggNOG" id="ENOG502QU9P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028269_1_0_1"/>
    <dbReference type="OrthoDB" id="5150166at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="11"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="396"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="70007" checksum="A55252D4A72A2BEA" modified="2011-11-16" version="1">MFPWKNNKFETKRDLFEAHDELFEPLVPTFSKGGARVRIAAGGSSCSYAAAELEGYSRPLWGIVSYQLGGGEFQYWELYRKGLVSGCDPKGDEYWGDPEGYSQILVDMAAVAYALCRCKDHYWDPLEPSDKTVVIEYLQNVRTKEFAGNNWKFFKVLVDLALEKVGVDIETVSTEIYLEDIESMYLGDGWYGDGKDKKHRIDYYNGFAFHYYGLIYYKLKKHEDPERCARYLQRATEFSKQYIHWFDSEGAAIPYGRSLNYKFATVGFWGLYASVLDINDSPAIPWGVLKYVYLSHFKWWSKQPISNYGSKLLTLGYAYPNNFMTELYNSPQSPYWSMKAFTGLLMDESHPFWTATPQQHHLDTKYMDIIGMHFSHHQKNSIVLVNGPWHDEYQPEKYSKFAYSSRYGFGVITNHRSFKSAHLDNMIGFSFNNKEFWVREYYEAWVAANGVMVSKWSPTYDVTVQSYLIPGDEYHIRIHTIENGTSRQLFTKEGGFAVDMNSHKCDGETDERISKVTTATDYSIICNILGERTTLLCKTEPNANLVFSKALIPELHGIIAPNSKVTFGSIISANLLANGSFSIDDIKNAEKKANISFEGASGPLKRVFCNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B962</accession>
    <name>G3B962_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_131813</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B962"/>
    <dbReference type="STRING" id="590646.G3B962"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001583_0_0_1"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000014">
        <property type="entry name" value="Cation/H+ exchanger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="967"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="12">
        <location>
            <begin position="250"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="545"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="867"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116483" checksum="F2F73F54A5C9D02E" modified="2011-11-16" version="1">MPDTINPKKPPGDVSNSRIVSGPTSGNASPTLKPKASSKLRKKSRPHIKRLPSGHNKLVFSVDDDIDDDIDDDNDSAPRRQAKLDKEYLEGYNDALKALYLKKSKKELPQQEGSSSYFPETPEMSKINEIDSSKYPPAEGTIRDHLLAAQENMKALEDLDEDTPLIEDDEDEEDDDEVESQSVKSSSSSQTMESLNLRERQDAINSTHPFGIKIWKPSLYKKKRSVATRAEEDIHEFNQHKPTINLGVHLSNFLWTITLGLFLYFVCTFFSVVLFFVSGFGIQKNSRVYIKLIYKVGKFWLHPFGKFVLLNKDENYLDEDDVYGSSIGEFHRWRREEEGRLFFAPPRRNTNSNNESQPLIKDHKGRALRDSYSFLQDNHGGSSHDNDEAHTSAIEEDEQDNRNDIKVRFFGRGSWTFPRVMFYLLFYCFLQPIFYLVGIVCWLLVFTIPMCNVTMLLCTHLKRHPLALHFEDEKKYYAGADQRKRANQSILLCTYRCSALHYYKYTIDGTNVFFMNLLMTVVFVIFDFYVLKERWELELFITKPVFLFCACLFSTIPLAFYIGQAVASISAQSSMGVGAVINAFFSTVVEIFLYCVALSQSKSKIVEGGMIGSILAGVLLLPGMSMCAGAVKRKTQRYNPRSAGVSSTMLLFGMVILFAPSLFYQIYGSYEIRCKICETTISAPFEDNCTTCRFIQPAFALDTLYYNIIRPFSFTVAVALLLAYACGLLFTLRTHASLIWATTSNEHSPHKKDEGMSLRSPSLTSIDSKKLKILSPILQASNGSSVDAKRPGGSSVSTALPSPSIEVTKQRNPKITIPIKSKPLTSNDFRPTTDALPTRDSLKDLKEDVEQGGGHDAPNWSRSKSSIILLSATILYAVIAEILVDVVDGVLQDFPINPKFLGLTVFALVPNTTEFLNAISFALGGNVALSMEIGSAYALQVVLIQVPVLAIYSMYRDFGDPLQTFSLVFPRWDIIATLISIYLFTYIYAEGKSNYFKGVILMLIYSVMLVGFYLNDFLESLDDGYNQPITSPSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3B999</accession>
    <name>G3B999_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_115295</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B999"/>
    <dbReference type="STRING" id="590646.G3B999"/>
    <dbReference type="GeneID" id="18247811"/>
    <dbReference type="KEGG" id="cten:18247811"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="10"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="380"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="211"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="49"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV61844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="494" mass="53703" checksum="C3606AD9085D8F3A" modified="2011-11-16" version="1">MAPVTIPKHYDYLVIGGGSGGVASARRAASYGKKVLLVEAKPHKLGGTCVNVGCVPKKVMWYAADLAHRKVHLSKYGLSRSSVEENEVKHGDFDWSYFKTKRDAYITRLNGIYARNLTNEGVEFLYGYARFTNDQADVEVTLTEDQEIPFLETGEKSFSKDQKFVFSADKVLVATGGAPIVPPSVPGAELGITSDGFFELDYQPKSVAVVGAGYIGVELAGVFRSLGSETHLVIRGDTVLRAFDDSIQETITDYYSDKLGVNVIKQSGSVSKVEKLANGLKKVYLGNGSTLEVEELVWTVGRRALSDIGLDVVGVKANDRGQVIADEYQQTSHSKVFSLGDVVGKVELTPVAIAAGRKLSNRLFSGQEVFAQDKLDYNNVPSVIFSHPEAGSIGLSEKEATDKYGKDNIKVYKSKFVAMYNAMLEDDELKQPTYYKIIVTGVDEKVIGLHMVGEATGEILQGFGVAVKMGATKADFDNCVAIHPTSAEELVTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9S2</accession>
    <name>G3B9S2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_135884</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9S2"/>
    <dbReference type="GeneID" id="18249913"/>
    <dbReference type="KEGG" id="cten:18249913"/>
    <dbReference type="eggNOG" id="ENOG502SUIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602845_0_0_1"/>
    <dbReference type="OrthoDB" id="4016002at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="457" mass="51659" checksum="F128F013B39D8F1B" modified="2011-11-16" version="1">MNTGLHLQFFGQNTSSHRLQLLNAQKYLQPQSQMYRPNSWIAFTAVIVAVWCLYISQTQNRTPHNNLIASSVFNKIVQCTDLLDGVYCLIENKRSLKAEIQLDSPQAQAQWETCLDIIGNTSDINLLLNIQSCYHTSVLSDKSSSPSISAFAVIISVILQILVGAHVIFDVLASQKNANDQGQAITAVSRRVDKCNEEIESLSSTTKQLQTDQYSNVRNIQGRLTKGGDIRQDIDILKQSYVLLAADVNNIKVAFLANVGSRVYDECTNENLDDWRRDQDRDRSLEYLQNTKLQSATPLPENSPKFYFVPDCSPHPQGSKDVLVPDLNSTIQNKENQPHYNSGIKSNGEVKEKNHTHPKLPHGVDKVNFDILTPEGRETLKTFIENKSQVNQKIRYRDLAYFKNGQRLKRIMVPNRGWVSGSKLQKEGEKYGSDSYVLGTTAHWIPQNKNFTSVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA30</accession>
    <name>G3BA30_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_115456</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA30"/>
    <dbReference type="STRING" id="590646.G3BA30"/>
    <dbReference type="GeneID" id="18247879"/>
    <dbReference type="KEGG" id="cten:18247879"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_5_1_1"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="358"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="512" mass="57261" checksum="AD48BDC8AB4D3C7A" modified="2011-11-16" version="1">MGTGWKLSPALREQLYRYAGYKQTSISLRQMVQFGPNPSPGSLFLASQFIVEELPIRLALKVKDLENAPLGLCNMPSTIKVQNWYAQSFEELVNLPKPTVSEELQRLLNQNGNARRVSENQILHEDNSVLEEKQNPVHEELNNPAINNVFSDDGIIIRHPSSSSAGANASSAAVSSRSMSESPTFGKTYYTPTAMNAVWPKEVYDYNKLVHDALSKIKKRHDATVATMAQGVQEWKNENKTVFVNSSIQTFLDRFYMSRIGIRMLIGQHLSLHMAQQKPKSKFAGLMNGTSGGSGSMKAKSNYVGVICTDCNVGEIAEDAIETAKYICEEYYGLFDCPEIQLILTKNEIQFMYVPGHLIHMLFETLKNSLRATIEFHTPRLKQKMIEKNPDLKPEDIDINDLKFPPVKVIISEGSEDIAVKISDEGGGIPRSEIPLIWTYLYTTVSQTPVLDSEYNQTSFKAPMAGFGYGLPISRLYAQYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAN4</accession>
    <name>G3BAN4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_109025</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687622.1">
        <property type="nucleotide sequence ID" value="XM_006687559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAN4"/>
    <dbReference type="STRING" id="590646.G3BAN4"/>
    <dbReference type="GeneID" id="18246078"/>
    <dbReference type="KEGG" id="cten:18246078"/>
    <dbReference type="eggNOG" id="ENOG502S0PF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094297_2_0_1"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="164" mass="18074" checksum="8143EB2039AE1268" modified="2011-11-16" version="1">MLSKLGLNTRAPYHLMIYSIAFGGSAFYSFFASPIAFKVLKREEFGVLQNSVFPYYFLGQTIAPGLLALTTPLTLCPFTSTLLVLSTVSSAINLFYLLPVCKDIKEKRLKLIEVGLDSIDGEPTEDFKKLTKSFGIHHGLSLLANFTSIVTLGVYGLVLSKRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAW2</accession>
    <name>G3BAW2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 13">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_114931</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAW2"/>
    <dbReference type="STRING" id="590646.G3BAW2"/>
    <dbReference type="eggNOG" id="KOG3442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101461_0_1_1"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="126" mass="14142" checksum="94921EFD4A1F4E3F" modified="2011-11-16" version="1">MAHRLIMNVIFTGASVFGRAFTEAYKQAAKVSASSAANSVAKSQSIGGIPVDESLKILDLDRKELSLDKVDEKYKYLFEVNSKEKGNSFYLQSKVYYAMDTLRKELDYLERLKEDKKKGSNDQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAY5</accession>
    <name>G3BAY5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_124204</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAY5"/>
    <dbReference type="STRING" id="590646.G3BAY5"/>
    <dbReference type="eggNOG" id="KOG2584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_4_0_1"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="62"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="372"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="592" mass="65301" checksum="2D8CEADDDD315873" modified="2011-11-16" version="1">MSFALASKNVLLDDHLVAATIIYSQQTGKILDIHHQILPRTDPVLALYHVAPENYRDVTPLIVMPGLVDAHVHLNEPGRTEWEGFATGTQAAASGGVTTVIDMPLNAIPPTTTVENFLLKISAAAGKCYVDVGFWGGLVPDNIDSLRPLIRMGVRGFKSFLIESGVEEFPAIKPKHILRAMKEVDGLKTLLMFHAEMQPNRNIDDLLNDSSNDTSDIDSINGVGNDIEDFDLGMSASFIHRAPKPVVDLLSRQHGPRGEYENVRFPHRPAGSIDRSGLTDEQAKALAKSPYLAGSEPIYGRFARMAHHHDSLAPGDDPKSPLLMAQREDKLLENIDPTSYASFLASRPDSFETTAIAEIINCSTMIPTVPLHIVHLATHEAIPLIRAAKAQNLPISAETCFHYLSFYAENIPKCSTHFKCCPPIRTDDNRKLLWKALRNDIITTVVSDHSPCTPDLKGLEKGDFFEAWGGIASVGFGLPIMYTEGLKLYPPITIAEISKWCSWNTAKQVGLSHVKGKIAVGYDADFVLFNPDMTYAVENQKTFFKNKLTAYHGMKFKGKVMETIVRGNSVFAFGEGHSSEPMGRMILEPRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB06</accession>
    <name>G3BB06_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_109471</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB06"/>
    <dbReference type="STRING" id="590646.G3BB06"/>
    <dbReference type="GeneID" id="18246117"/>
    <dbReference type="KEGG" id="cten:18246117"/>
    <dbReference type="eggNOG" id="KOG4116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156007_0_1_1"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="95" mass="10981" checksum="2A01B035457CC3D1" modified="2011-11-16" version="1">MAGPPAAKHYMGWWGAIGGPKQKYVNQYTVTPYATRPLKGNLHKAFFNTFRRVKNQALFVIIPFSIVWSIWAQARDYNEFLYTKAGKEELDRVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB25</accession>
    <name>G3BB25_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115589</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688295.1">
        <property type="nucleotide sequence ID" value="XM_006688232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB25"/>
    <dbReference type="STRING" id="590646.G3BB25"/>
    <dbReference type="GeneID" id="18247927"/>
    <dbReference type="KEGG" id="cten:18247927"/>
    <dbReference type="eggNOG" id="KOG3912">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025028_3_1_1"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="380" mass="41715" checksum="DFC08243B5E76A62" modified="2011-11-16" version="1">MNSNVTLLVFVVGTIVTGCLNSIFTKYQDNQCVDNCSDPDVSNHHTFQQPALQTLQMFVGEMLCYVVYYLMYRTSLLSFGADGYKPIGEDADLPQLPLASSLKLSVPAICDLVGTTMLHFGLIFIPVSVYQMIRGSLVLFVAFLSVVFLKRKVTRLEWLALVIVTGGITLVGLSGSSQGDGAAEGTSKMVMVGLVLVVVAELCQAFQFVVEEHLLRKNPIMPLQLVYFEGFYGAVVLAVALVVLYFVLGAVLDPSDFEHSPFNMKEGLSQMLGSYHIMGASVLIMLSISSFNFFGISLTFHLSATSRSTIDACRTLMVWLLAMIMGWESFHFLQFVGFGLLVFGTLCFNGVLTPEEWSWVPGVLKSSVDVAPLEEPVDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB64</accession>
    <name>G3BB64_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="4 10">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_107882</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="4 10"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB64"/>
    <dbReference type="STRING" id="590646.G3BB64"/>
    <dbReference type="eggNOG" id="ENOG502S7VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046294_1_0_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="331" mass="39350" checksum="754D7B3B85E15B53" modified="2011-11-16" version="1">MEISKLTSPQEWKYFAKGNANILFEYTGSNDYLRHKLLRLRLLKEDDQYISTCELYDFIELRCKHLFPEMIIDIQLVVLTGEFVHNLDSNGHKMMIQERYGLLLPNILEGENNKQALSKNCNLYFDDQFNAITLELKPKWLYDNKNNNYCRTCSLNQLRGFERHFCPLDFLYPEALQEGLDDVFKAVPDDLVQQIQKNIPVKQLFMQYLQSPKNVFQKLKQYQKINDKNDLIENLTSPNDVSVNLWLVMTLRDVGLFLKFEKYDRNNNIHNSHNNVNNLITIDNGKYLLTSNIYDLDLKSKSKYKHWLNIEHQLQPIYNSSNPTWRYCIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB99</accession>
    <name>G3BB99_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114995</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB99"/>
    <dbReference type="STRING" id="590646.G3BB99"/>
    <dbReference type="GeneID" id="18247661"/>
    <dbReference type="KEGG" id="cten:18247661"/>
    <dbReference type="eggNOG" id="KOG2969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057411_1_1_1"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="150"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="248" mass="28418" checksum="FB3AE359A7BDD72E" modified="2011-11-16" version="1">MSNRFWSRGLQSVRRYHAYDHPASNLIVDPTKLENKLLTKSLEYIPQFGFSDQCISEAIKQMQYPDSIRSILTASFSGHSTELQLMVHWLKTQRQALDSEVNSPDSQLHSITDEYERASFLINKRLSYNIPIIDKLSGGISQLLVPYNMSFSLEELYNLGDDIAFHAGDASIDFAWYAKRLSLSMVYVSSELYMVQDKSADFVNTKKFVEDKVKNIDHLGEAYENIEQWAFFNAISAFNLVKSQVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBC1</accession>
    <name>G3BBC1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115619</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBC1"/>
    <dbReference type="STRING" id="590646.G3BBC1"/>
    <dbReference type="GeneID" id="18247937"/>
    <dbReference type="KEGG" id="cten:18247937"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_3_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="32"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="309" mass="35726" checksum="502860A7DF2A40DB" modified="2011-11-16" version="1">MPIVQLRSDDKSHSAIANISQAQLSYPQYSKIILLLHGFPDTNASFDEFTPKLIANLPASEKIAVVAPLLRGYERSSQTDFSRYRTVDLALDIKNFLTQNFSYTRETTTIHLVGHDWGAISCFKAVSLYPDMFDSVSTLGIPYLSNLHVWDLFLYASEQLWYSSYFLTMQWRSLYGRIDTEHTESSYLNRLWEFWSPRWNYSNHDIEQVRTMLQNNGVLDHATAYYRCLLDPRNLKSIRWKIDFEKVPVLLVGGKLDGCMTIRLYELEKKRLESTSARVEVVEGAGHFLHREAPAKVADLVADWILEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBH3</accession>
    <name>G3BBH3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_95082</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBH3"/>
    <dbReference type="STRING" id="590646.G3BBH3"/>
    <dbReference type="GeneID" id="18250475"/>
    <dbReference type="KEGG" id="cten:18250475"/>
    <dbReference type="eggNOG" id="KOG3324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063935_1_0_1"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005681">
        <property type="entry name" value="Tim23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00983">
        <property type="entry name" value="3a0801s02tim23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="208" mass="21909" checksum="707494196DA3074B" modified="2011-11-16" version="1">MNWLLGGSPQTQEHQGESSTLGFDAKEVSNISSFLGQPGLFDSQKLHPLAGLDRGIEYLDLEEEQLNTVEGAQGLIPSRNWTDDLCYGTGAVYLLGLGVGGAYGFQEGLQNLPANSSSRLKLNTVLNHITKRGPFLGNSAGVLALTYNLIDSSLDAVRGKHDDLNSVAAGALAGALFRSSAGVRPMGYSTVIMAAAAGAWCGIKRVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBJ3</accession>
    <name>G3BBJ3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115019</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688729.1">
        <property type="nucleotide sequence ID" value="XM_006688666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBJ3"/>
    <dbReference type="STRING" id="590646.G3BBJ3"/>
    <dbReference type="GeneID" id="18247676"/>
    <dbReference type="KEGG" id="cten:18247676"/>
    <dbReference type="eggNOG" id="KOG3281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054226_2_0_1"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="299" mass="34889" checksum="B83AA6CD6515C169" modified="2011-11-16" version="1">MFLRRSLTFRQIIWTKQCQPHTFYRLNSTKAELLQKYKDKLEAKAKILGYQSVEDLNESLKDDIEARKKQLNAIDPLKDLEGFEAEQASKMKKNILDHQIKIRDPIKRDAPIAPYKTLDSFVDSAKLKDLNKQEIEYIWRARFQKDDRSMVAILGATQFSNMYALGFKNRTFILPLAKESGGYEMHFVQWSFVGPETTHCMLTTLAEYKLHNEYAKPHSTIMFHQELAHEKDVVLMNCHVEKESNVSLADAQFLILNIQRFYGAMKSISKAKLELLEAFNRGEEMFDMEKLIEEATSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBJ4</accession>
    <name>G3BBJ4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zf-DNL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_94442</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBJ4"/>
    <dbReference type="STRING" id="590646.G3BBJ4"/>
    <dbReference type="GeneID" id="18250398"/>
    <dbReference type="KEGG" id="cten:18250398"/>
    <dbReference type="eggNOG" id="KOG3277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093902_1_0_1"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="178" mass="19915" checksum="630438D2E22C1012" modified="2011-11-16" version="1">MKRALFIPRATTGSLKARMMFQSARVLVYKTRILGGHSVTSQLVPARFQSTNNKTASLKVDDPQLMIAFTCKKCDTRSSHTFSKQAYTKGTVAIQCPGCKNRHLIADNLKIFKDDKFSLEEVLKAKGESVSTSTEDLVFNDIPESLREKIGHHARDAPEDYQKKLEPENTALPKGNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBN2</accession>
    <name>G3BBN2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subunit of N oligosaccharyltransferase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115042</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBN2"/>
    <dbReference type="STRING" id="590646.G3BBN2"/>
    <dbReference type="GeneID" id="18247689"/>
    <dbReference type="KEGG" id="cten:18247689"/>
    <dbReference type="eggNOG" id="KOG2603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052855_2_0_1"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF3">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833555" evidence="6">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="338" mass="38213" checksum="65749C96D5AA42A1" modified="2011-11-16" version="1">MVIVHSLVWVLLLGVLVAALSSQEALGLTELSQKSEDFIIRVTDGKLDSFTGVRDYYTLVILTSTSSEHKCTTCQNLIDIVQIVARSWFHDYTRSHALFFVEIDLVHEPNMRLAGAIQLQTVPHLWLVPPNPEEQYDEFALLKEQHFIYRLPVGKVDSQAFDLAQFLSQTLQKSIYIRDGDPMVNFVLYFVVTFLVITICKRNAPQLVKNLGRVFAYKVLSIGMILASTTGFQYSRIQKIPFVARNDEGLIIISGGTHYQFGVESLIVSGVYLLLAVSFLVLVYLGSYKTTAKSTLDDQSKHILIISMTITLYLLYSALTSIILRKDSDYPYAFTKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBP0</accession>
    <name>G3BBP0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_107319</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBP0"/>
    <dbReference type="STRING" id="590646.G3BBP0"/>
    <dbReference type="GeneID" id="18245946"/>
    <dbReference type="KEGG" id="cten:18245946"/>
    <dbReference type="eggNOG" id="KOG0291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010458_0_0_1"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000602">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="337"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="379"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="465"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="9">
        <location>
            <begin position="741"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="854"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="855"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="901" mass="101850" checksum="8B5F41C11BE0C6B1" modified="2011-11-16" version="1">MKSDFKFSNLLGTVYRRGNLVFTEDGTKLLSPVGNRVSCFNLIKNECFTFNYEHRKDVTTIALNKQGTLMLSVDEDGRAILINFVARTVLHHFNFKDKVLDLKFSPCGNYFAIACNRFIQVWKTPDFTDDRQFSPFVRHRVYSGHYSDVTSISWSKDSRFFLSTSKDMTSKVYSLHSDESSVAMTLAGHRDYVVNAFFNDTQEIIYTLSKDGALFRWEYTERPGEESDSDDEETDTEKPQKHLSWRITAKNFFYADSHVKCATFHPQSNLLVVGFNNGEFRLYELPEFVLVQQLSMGQNPINTVSINRTGEWLAFGSSKLGQLLVYEWQSESYILRQQGHFDSINCICYSPDGGRIITGSDDGKIKVWDNRSGFCLMTFTEHTSSITGLQFSKKGQVLFSSSLDGTVRAFDLLRYRNFRTFTATERIQFNCLAADPSGEVVVAGSQDSFDIFVWSVQTGQLLDRLSGHEGPISGLSFGVESSVLASASWDKTIRIWSIFSRSQSVEPIEVQSDVLSIAMRPDSKEVSISTLDGHIVTFDVEDAKQVHLLDGKRDIIGGRYKEDRFEAKNSARAKNFTTIDYSFDGNFIIAGGNNNSICLYDVKNEVLLKKFKVSENMKLDGTLQKLNSKNMADGGALDLVDRAGENSDLEDRVDNSLPGSRKGDPSLRSTRPAIRVASIRFSPTISSFAAGSTEGLMVYSVDNEMVFDPFELDIDITPQTIIETLEEKDYLKALIMSFRMNEVKLIRLVYDSIPVKDIKVVAKDIPVVYLERLLRFIGERSIDSIHLELHLIWINSLLLSHGQYIGVHRYEFTHAMKLLSRFLNKYAKSIVKISKNSDALTGFLTAAVKSKDQAEEFEGFEESEHEDMDEDSDESEGEWLGPTADSKGFADVFEDAVDMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC13</accession>
    <name>G3BC13_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_111988</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC13"/>
    <dbReference type="STRING" id="590646.G3BC13"/>
    <dbReference type="GeneID" id="18246336"/>
    <dbReference type="KEGG" id="cten:18246336"/>
    <dbReference type="eggNOG" id="KOG2847">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046747_1_1_1"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="71"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="396" mass="45269" checksum="D8808A12C3895EF9" modified="2011-11-16" version="1">MSFEDVITRGEDFLRGAPRDSHLWNAASHATCFAMIVGSKFFLNLLYKPELHHIDKLDAALVRARSENRGLLTVMNHMSVVDDPTFYAALPWRFHFDVDTIRWSFGAHNICFSNSALSLFFNLGKVLGTKRFGYGQFQGSVDAAIRILSPDDTLDLEFAPDFNKKPKSVVLQEVNNGPIAKTAQPAPLMSRSPFIRTKTSWFHVFPEGFVLQLEPPHNNSMRYFKWGVSRLLLESTRAPVVLPIFSYGFEKIAPENTAEEGIKRYLPSNIGAEVHIWFGDEVEDAKIETYRSRWRGLCAKYFNPKHPNDLSEELRTGKKAQQLRSEVAAMLREAVLNVRNSTGHFNPEDPRFKDPSFWKEYTRTEGASAPDVKFIGKNWAIRRLQSHLPEYDHSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCF5</accession>
    <name>G3BCF5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Intermediate filament protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_128486</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCF5"/>
    <dbReference type="STRING" id="590646.G3BCF5"/>
    <dbReference type="eggNOG" id="KOG2101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002131_1_0_1"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="104"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="697"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="655"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1031" mass="118950" checksum="16D8E7A03DFF64CC" modified="2011-11-16" version="1">MLPAFIYQILEHKPVRIASYAVGMYILYIVVLKRLLLYMYLFFSGMAVMVGVILYHIFVFSPPRIPHKRATRRFKLLNIDLWQDEQVKLSVDPAEVNKPIVEEAFLISETLEDFISLIIQEFIDGWYTRITSDSLFQDSIRVELNQVFGQLKNRIVDIDLAKLLVSKLVPIVNDHLSDYIRAEERVQGKINSHKRSGDSIDHDIDVARHYRRGKIHPAVTVSKTGASNINEKDYLRAKVGSFLPYVLSEREKNNDIGLSLVREILACTVLANVFQMLGEGDFYNLLIVKLIGDNLKRRDQVKKLRAALDEHTQQKHDDETTKINKDYILLQLPSPSDSKLISRLREVQSLVETKIKELERTSGLGLLKVLHNTVYLDEFSKYLDENSRGVLLQFWLAVERIKAPLELTDDKLSLSLGFSNSNEIREIHQKYLHQIGASNDDLSVIEEYINSQDLINKSKLYQDARDRLFRLQESTYTKLEYDFKDFTTTDRYRDLVQSVSHSVNDSNVVSPTVIKAVEDAFTRIMKNNTDLDAAYESERQAQASELKRGLFGESSSLFQDTLNHNAQKYSKLFDDLSDESGTDSDSLNFDSDSNTNLQSSMELDADALGDDQQSLLLAAPGDLKLAEEIDKLTNDISVLNEQLTILDPLIKKAELTNNISEIKILKNSKASLEREISSKELQKQQYIVQENDNSLYGKSRVKISSYISGNENGNDFILYIIELQRFSNSDPNTNTAGWIIARRFSQFFKLHEYLRSRYPQVNNLKFPKRTVFKLQQKQIVELRRAALEEYLKELLEIPEVCSNRVFRSFLSSENFNVRKNQSFEETTKPKKNTVEALYQGISNRFVGTNKKPKASENIEENMSNLRDMERELKSFDEREVFIKPLINILMTVFKLKNAKSWLRGRALLVILQQVFGTTIEKKIYEQIAQIQQEESILDVLILLKNIVFPNGKFRDPPVIRSAVERYTTQEESRFLLSVFMSETFSTIFGVGNTKYAFSVVFNCLQNDFLVRHLVFELFDEIVDELFPELNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCJ2</accession>
    <name>G3BCJ2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oxidative stress survival, Svf1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_127148</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCJ2"/>
    <dbReference type="STRING" id="590646.G3BCJ2"/>
    <dbReference type="GeneID" id="18249222"/>
    <dbReference type="KEGG" id="cten:18249222"/>
    <dbReference type="eggNOG" id="ENOG502QQY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030205_2_0_1"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="57"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="218"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41985" checksum="4C928C6B4316EE6B" modified="2011-11-16" version="1">MLKWVQSGLSVVAGTAEPEYGREALHPVTDKVKEGEPCYRETTLKDLNWLGPNYTNVETQTFYFTCLKTGYTGFAQVIHSNIMGVHTTAQFTFRIYDDKGKNNLWTSTHLENFRTEGSNFYADNMSIEFNEDGTEVILKSDVNPDSVVEFTMKRLVPGVIFGGDGTTLYGEDVEEPWGSMRHCFWPRCEVSGTIVSKALDTTLEINGLTMFVMALQGMKPHHAAKSWNFLNFQSENYSAVQMEFTTPRSYANTKVNIGVVCGKDKILLASINNDVVHENAEIDEVGWPVPKAITFNHDAADKSYHVDVKGELKSLVERVDVMAEIPQFIKNIVSGVAGTKPYIYQYCNKMTINDNNVASETGVAFSEATFISEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD43</accession>
    <name>G3BD43_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116959</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690517.1">
        <property type="nucleotide sequence ID" value="XM_006690454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD43"/>
    <dbReference type="STRING" id="590646.G3BD43"/>
    <dbReference type="GeneID" id="18248522"/>
    <dbReference type="KEGG" id="cten:18248522"/>
    <dbReference type="eggNOG" id="ENOG502S522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1190278_0_0_1"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="13"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="236" mass="24785" checksum="3C2E2DF3F70A465A" modified="2011-11-16" version="1">MLGLFSTLKGRVTLGVRATQLLFSIIVLGCGAALASTSFTSGRAGLCIATAVLTLIYIALTVIPKVYPLLPTISLLVSESVLFILWLASFASIADAQYGSISCDIGDYGYYHSILHDYRKACHNGKALLAFAVLSWLLSIASLALTILYVVIPAAKTKTLVAGGNNVLTGALFDIDVSPALKTTNTGVVTDEENKAESDQDVVKEAETEAEADVPEPTVADPDTTEVDLSAPAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD96</accession>
    <name>G3BD96_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116334</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD96"/>
    <dbReference type="STRING" id="590646.G3BD96"/>
    <dbReference type="eggNOG" id="KOG1951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2334196_0_0_1"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="101" mass="11980" checksum="5FDD64A13EA174F4" modified="2011-11-16" version="1">MKPQSKKTYMSKRAVVLGGEEKKARDLMQKIATVRKEKETKRKTKKDVKFKDRLKEIAKREEAKKEKQKERKKEYFSKSGNKRALSASEDNHNAFGKRQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDG2</accession>
    <name>G3BDG2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_127402</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDG2"/>
    <dbReference type="STRING" id="590646.G3BDG2"/>
    <dbReference type="GeneID" id="18249237"/>
    <dbReference type="KEGG" id="cten:18249237"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_3_0_1"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="862" mass="98878" checksum="2F9DA06A2859E1E5" modified="2011-11-16" version="1">MEAFFAFPSDEKVISPSDFKENESNKFSGRILNCMTTIPNLICKEQNGWKVEPIRGQSSLYSSHFFLARQTDWETHLIGWTGEIVNKQTNTNFASAENIQDDPLYLSDSAKDEIEQKIREVNQTENIHPIWLLRRDQERWRKYAENCIWPVFHYIQSQDMNGRNEGVNWYDYVKFNESYLQKIKAIYKPGDIIWIHDYYLLLLPQLLRMEFPDAYIGFFLHIPFPSSEYFRCIPKRSQLLDGMLASDRIVFQSDSFQRHFISCCARVLGCEIKANKVFAYGSNIYTDTLPIGIDTKKIEHDCFNSAIDEKVDVLKEIYSGKKIIVGRDRLDSVRGVVQKLEAFEMFLQMYPDWRDKVVLIQVSSPSYSSHALKMEKKVTELVNHINSEYGSLNSIPVLHYQIRINKDEYLALLRVADLALITSVRDGMNTTSLEFVACQKKNYSPLILSEFTGTATVLNDAILVNPWDSVGIARTINKCLVMSLDDKRAYEDKLYKKVCSNTIQSWTNNFLTGLINQLTGRSKYTYTPALNRPSLLNHYLKSERRLFLFDYDGTLTPIVTDPEAAIPSKRLNDIIEILSVDPRNQIWIISGRDQKFLAKWFGDKNVGLSAEHGCFMKDLGSSEWVNLAATFDMSWQQEVEEIFQQFCKKTPNSFTEKKKVALTWHYRRSDPDLGEYQAKKLKEYLQATVVPKYDVECMSGKANIEVRPKFVNKGEIVKRLVLNPHGTKQDPKPIAQHNYELAADQVPDFILCLGDDQTDEDMFKSLKQIETNWNLKAYPRNGFGHYGVYPVYVGSPTKQTIATAHLSNPSQVLETLGLLAGQVSVFESAGSVDLDDRGHIEYSESSINSKKKAAASRSESST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDP7</accession>
    <name>G3BDP7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_136835</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDP7"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184879_0_0_1"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="234" mass="25739" checksum="EBA0D2BFB0D8E69B" modified="2011-11-16" version="1">MLDSRTKLPSISELTRSHEVKLPDLSGYTASQPSLATPIKLPSLSQLTHYSPAYTSANGNTATTTNTTTPALQPAYKFGTNYQYGKSPRQMVSPQQMVSPPPVVTPPAAHGQHIHSPTEFPVAQQSGYSYYMPYYSVYYGQSTPSPQQQYLVPEVINKPINKCHRCGTTETPEWRRGPNGVRTLCNACGLYHAKLVKRKGAAIAAQEVLNNKVRKGKNGRRVSIKSAMINSKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDW3</accession>
    <name>G3BDW3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MEU1</name>
        <name evidence="6" type="ORF">CANTEDRAFT_116449</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690341.1">
        <property type="nucleotide sequence ID" value="XM_006690278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDW3"/>
    <dbReference type="STRING" id="590646.G3BDW3"/>
    <dbReference type="GeneID" id="18248312"/>
    <dbReference type="KEGG" id="cten:18248312"/>
    <dbReference type="eggNOG" id="KOG3985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_1_1"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="333" mass="36945" checksum="9C81A2B5CFAF2C3A" modified="2011-11-16" version="1">MVKKVFPKLMSELSQLPHSYSKPVELAIIGGTGLYDLPNLKPVARLTVSTPWGFPSSPITISEMADGFPVAFLARHGQHHDLLPTDVPSRANMAALKSLGVKAIVAFSAVGSLRQEIKPRDFVLPTQVIDRTKGIRPSTFFEKGFVAHAMFGEPFDLKLYKLIKEAIPAQGFLEGFDKENLEPTFHTKDKEDLTLICMEGPQFSTRAESQMYRSFGGSVINMSCLPEAKLAREAEIAYQMVCMSTDYDSWNVDEDPVTVETVVGNLKANSANACKMAEKLIEVISKEFETGKSEIGEDLKGSMKFSVSTNPKAVKKELLEKMHFLFPGYWPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDY4</accession>
    <name>G3BDY4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116460</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDY4"/>
    <dbReference type="STRING" id="590646.G3BDY4"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043291_0_1_1"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="103"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="287" mass="32871" checksum="6967001436F3A41D" modified="2011-11-16" version="1">MSEKIYQGDDFDAKVTKQVEFYFSDSNLQTDRFLWKIYEANDGWVELKTILTFGRMRQYRPEDKVVEALKKSDKLVLSANNESIRRKDPLKEFNELKNSRKRNTVHIEGFPKTATQEDLEDFFNTKVAGNLPEEKVISSIRRIKNKSTKEFFGVVDVEFKSTKDAEFVLNEMEIVYPTGLISKNDEVTKKDVLKKMSLLTFQEMRENGKRFGINDVTKRKNSFNSNKDVKKFKHDQKKAKKETTEESVVEEETTKPAGSAESESAEPAETSASAPTSDETPAATESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE08</accession>
    <name>G3BE08_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689642.1">
        <property type="nucleotide sequence ID" value="XM_006689579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE08"/>
    <dbReference type="STRING" id="590646.G3BE08"/>
    <dbReference type="GeneID" id="18248323"/>
    <dbReference type="KEGG" id="cten:18248323"/>
    <dbReference type="eggNOG" id="KOG3089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086112_0_0_1"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31998" checksum="94165A4399FFF8B1" modified="2011-11-16" version="1">MTKEDYAGDDLNDGLEYEIDLSDAPEQGGIPHGALESEDEIAEASEIEDNEVAKLSTEAKAGKKRKATDSKLKEKKKMKMEIDLEQKKSISKESSTEVIADYINKTVAQKNKKLSSLELSDLYISKNDIRSTSEIEGPRNLEGLASYLNTRFKNMLPAGKKGKRSGNDDERKFIVIISMSAIRACDVYRSTKNLNGSSIKLINKNKIAADIKLLQVSKSRVFCCTPTRLKKVCEHEENVLNKKEVKIVILDNSYLDQKGQNIWDIPETIQVLKELTDNGAKVYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE30</accession>
    <name>G3BE30_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CANTEDRAFT_132201</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE30"/>
    <dbReference type="STRING" id="590646.G3BE30"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004875_2_1_1"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.180:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000443">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442660" description="non-specific serine/threonine protein kinase" evidence="22">
        <location>
            <begin position="22"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="625"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="24">
        <location>
            <begin position="937"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="517"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="578"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGV60443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1066" mass="122214" checksum="042D6897F06BD0D7" modified="2011-11-16" version="1">MNPWIALLILNFWGLLCVVNAKPSYTKSYDPRIVTDHEYEANIFPIDLRSLRDYSLSDYLLINRNTGNLLWTLPFDEPLIKIETNGSHSNADTNILWFVEPYNDGSLYYFTPEYGLNKLPASIKELVLQSPFFLSGDDKIYTGTRKTSLYTINVHTGELMGQYGDSEDSGPKPTTAYEYGQDDVDCIMIGKTVYELTIHSQSNSNVVWYVTYTQWGPNNIDNDLILQNQKSMDKLYFTPFHDRSLLAINQDLGTPIWISKLPSLTVNVFDIFNNPKSKNDFVTLPHPLKVLNNLQVNHDDTINDDLCFINRTANSKQWFAMSFENYPTLIKSAPIAHYQMSLFKADNDIRDLQDLYHLRYLDPVSKFKDILVDYGIDDGTTIYGLPETDTQGLVVHRTTTNLPFANIIEGIRFHTASKVDGKSFPTSHKEQNMFAIDQPEQLEYLPGPNSEEYHPYKVQHTRPSLFRRIIEDIAVLLSLLAVFVLGVRIMRRVFSNWKIEFVVNIDNINGLAGNATEEGELDPKLPPSGEKVTDNLNEGKKDGIVSKENGVTDSGSADSSEMQRLTLVDPIKAEDIEELAKKRQRKRGSRGGKRGNKSKKPEDNDELDELVFSETEELQIENDLIISDKILGYGSHGTVVFQGTFENRPVAVKRMLLDFYDVANHEVSLLQQSDDHPNVIRYFCSQSSVSEKFLYIALELCRGSLDDLIERPKISANFTHLKNLTLNYSDLLYQLTNGLNYLHNLKIVHRDLKPQNILIGEVKNKNNGKEQDNSDSNFRLLISDFGLCKRLDNDQSSFRATTQNAASGTSGWRAPELLLNHDLLEISPDTISSIGSNSPSNNNNSNSTGGIKRLTKAIDIFSLGCIFFYIMTKGNHPFGDRYMRDGNIVKGIYSLSLLDDCKDRYESKHLIASMIDQNPDKRPNTRDIMKHPFFWSKGKKLEFLLKVSDRFEIEKRDPPSPLLLELEKASRRITGGNWHVKFNDEFMSNLGKYRKYQPEKLMDLLRALRNKYHHFNDMPLTLQKKMSPLPNGFYDYFNSRFPNLVMEVYFVVERNLKKEHIFEEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEJ6</accession>
    <name>G3BEJ6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_99946</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEJ6"/>
    <dbReference type="STRING" id="590646.G3BEJ6"/>
    <dbReference type="GeneID" id="18250891"/>
    <dbReference type="KEGG" id="cten:18250891"/>
    <dbReference type="eggNOG" id="KOG2240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098726_2_2_1"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006613">
        <property type="term" value="P:cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="14">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="153" mass="17074" checksum="1413F45212830CA3" modified="2011-11-16" version="1">MPIDPEKLAKLQKSSSKKVGGSRIKAKKVIKEQDDVKLMETLGKFKATKIQNVTEANFFKDDGKVLHFKRVGVQGANDYNTFAFTGYPQEVEVTKLIPDILPQLGAENLEILSQLAKQIQEGRTPQLDKEGNLAADDEEIPDLTEGQKFDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF43</accession>
    <name>G3BF43_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Modification methylase HemK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116699</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF43"/>
    <dbReference type="STRING" id="590646.G3BF43"/>
    <dbReference type="eggNOG" id="KOG2904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_0_2_1"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="104"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="283" mass="32075" checksum="78A6A9B9F48DB573" modified="2011-11-16" version="1">MRISPKTIREARQISRLLPPLLRPTRSLEVATQELSWIKRELPKSAWKNAVLQRMNHTPLQYILGTQPFGDMDLITKPGVLIPRWETEEWAVKVLDFLISNSANNIRILDACTGTGCIPLLLNSQLQKAGIPHTIKAIDISPRAIEIANENSTKYSSTVEFEQQNLFTLKPEPFDLVTSNPPYIPMKDYLSTEVEKSVRRYEPKEALIGDLEFYTQLVHTVDDCDADNFIFELGYQTQAEHVKRLVSSEWTVGTLNDSAGNLRCVIGSKNMELNLTSLCNTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF49</accession>
    <name>G3BF49_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_100004</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF49"/>
    <dbReference type="STRING" id="590646.G3BF49"/>
    <dbReference type="GeneID" id="18245348"/>
    <dbReference type="KEGG" id="cten:18245348"/>
    <dbReference type="eggNOG" id="KOG2675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015780_1_0_1"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028417">
        <property type="entry name" value="CAP_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01089">
        <property type="entry name" value="CAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="370"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="534" mass="58338" checksum="3CBE71F29EE4063B" modified="2011-11-16" version="1">MSSEENQLNVQGYNIVTILKRLETATSRLEDITMIQDQASKSDPRAPPPLSQLPSAPAAIGAPPTDLAVWEPTAEAKEEEPEEKAKSTVVFEEFIEEHVKAFVNRSKSLDSVVGEAAQAFYEAFQEQAKFLEIASKSKKPEMTDPAFADAVNPTNTQIQKISSVKDSNRSSKFFNHLNTLAEGAPVLGWILSPTPVSYIPDFKDSAQFWSNRIMKEFRDKDQSQVDWVKEFLGIFEPLKDYVKEYHTKGPKWNPNGKPLSEVLAGASKVPAPAVGGAPPPPPPPPPPASLFDETETKSVSNAPASGMQAVFADLNKGEAITSGLKKVDKSQMTHKNPELRKQAPVVPKKPTPPKKPSSLSSGSSVPAKKPARKELIDGSKWIIENYTRADLKGDEVQSITIEAEMHQSIFVGNCEEVTVLVKGKANAISVSNTTKCVFIIDSLISGFELIKCHKFGLQILGTVADVSIDQCDEGDLYLSQDSIDKDIQIVSSSTTALNFNVPKDGDYIELAAPEQFKHSIKDNKLVSEVLQHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF55</accession>
    <name>G3BF55_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_109854</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF55"/>
    <dbReference type="STRING" id="590646.G3BF55"/>
    <dbReference type="GeneID" id="18246147"/>
    <dbReference type="KEGG" id="cten:18246147"/>
    <dbReference type="eggNOG" id="KOG1166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002115_1_0_1"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="6">
        <location>
            <begin position="51"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="565"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="875" mass="100987" checksum="42BC28C1FC0D1A73" modified="2011-11-16" version="1">MSSSLNISEIEAQKENIEALPGGRSVSSLTYSLKQHGTHRKDLLNQQRQEFEDEVADLDDLDDPLEVYVRYIRWCHDSYPQGNNAESRLLEILEKCTTDFRDFNQYKNDSRYLKIWLEYAKYSDSPTEIFIYLAKKEIGRELSLYYEEFAKVLELRQKFSDAQDVYHIGLQNNARPVSRLIRSSKQFELRKSSQTTDRSDSEVKRVLTLKRGSNPSPEESMPATFKKSKISVFTDDSNLRMADKLFDGKAPSKDILDIQLRKKENVFTPRPWSGEILEQIRPSSSSSSSNKIPVYRDIGVPVEEATQYEVHLTSPNEISTIVKRPGKKPEQVHANLDLIYPEHGEEVSLVELLMLSRTKNMELSSQVHEETLPTQGDSQSASYQENARFTDTFTIPLKDDDTTTFQPRNILQSPTVTLYSKAANNEVMSMFNDVSKMPHESDFEDDKSEGGNSTNYDEFVTETLHKAPAKLPTVQDQIVSSSHIDSFGGTNRNQPQVVDPLSEKLREKLLSGISPPLETYPGYNNTKTHFIEAIRKFRSITDKDTKIVAKGSSGSIVNFCGDEIFSLKCELGQGGYGYVYLIENEVGMLKALKAETISSNWEFYILNQLHRRLKHDPLVDSRLVNPESLYMYKDESFLILNYLNQGTLLDLVNYYKGEGDTVEEILCIFFTIELLRVVEQLHRVGVIHGDLKADNCMIDLKNTFSMSEHYDNKAHEANEWQSPRLVLIDFGRAIDLTLFPEGTEFSSDFRTDEQDCPQMREHKTWSYEADYYGIAATIHTLLFGDYIRVNKLPNGKYKLQNSLRRYWQLPLWQPLFEILLNPYYNVDEKIPLIDELKYQRVRFEEFLKQNSAKLGLKRVINNIERDVYKIIPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFW3</accession>
    <name>G3BFW3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_117012</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996529">
        <property type="protein sequence ID" value="EGV59918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFW3"/>
    <dbReference type="STRING" id="590646.G3BFW3"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV59918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="280" mass="30491" checksum="55D075FA85EA03F7" modified="2011-11-16" version="1">MSDSKTVVVTGASSGIGLAVAREFALKGYNVIAGARRLSSMEELKKYNVTTVELDITSPESVEKLKKLIETEYDGAIKYLLNNAGQSCAAAAVEVSDDEVFRCFEVNVFGHIRVTRELAPFVIKTKGTIGFTGSVQGILETMFLGVYASSKAAIQSYASGMAFEMAPFGVKVVNFVTGGVRTAMSGIDLKSVLYDEEGLEEVKKAYSELTKTGMDSHVYARKVIKDFEHSKLGVVHHYRGAGSTTVWIAHTFFPKFVLSMLFGSVLKLSTLLKSITNKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3AVY7</accession>
    <name>G3AVY7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112070</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996509">
        <property type="protein sequence ID" value="EGV66895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AVY7"/>
    <dbReference type="HOGENOM" id="CLU_2775711_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="69" mass="8049" checksum="DFDF626EE2B1203E" modified="2011-11-16" version="1">MKGYCCPQKYGKGGEIRSTILFIGRGQYQLSCNYCNVLKDTPPRFPMYYKPLKTFDSNPVSNYEQSFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWA5</accession>
    <name>G3AWA5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_132749</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWA5"/>
    <dbReference type="STRING" id="590646.G3AWA5"/>
    <dbReference type="eggNOG" id="KOG3886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044099_1_0_1"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="326" mass="37799" checksum="06CAC2A76C09906A" modified="2011-11-16" version="1">MSSSRKKLLLMGRSGSGKSSMRSIIFSNYSAFDTRRLGATIDVEHSHLRFLGNMTLNLWDCGGQDVFMDNYFTTQKDHIFKFVQVLIHVFDVESKSINKDIEIFIKSLTNLQKYSPDAKVFVLLHKMDLVQIDKRDELFNIMMDKLQKISNPYQFKLVGFPTSIWNESLYKAWSQIVCSLIPNMNLFNDNLLKFNRILDAEEIILFEKTTFLVISSTNSIRQQLNGTTTNSLDNLDPKRFEKISNIIKTYKQSISKLRTNFNNLIIKGSNDTQFFIDGLTDNMFIMIILKDSPSKSGEYVNNKEELIVLKNIKSARKWFEKIESVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWB5</accession>
    <name>G3AWB5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112220</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWB5"/>
    <dbReference type="HOGENOM" id="CLU_3032166_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="55" mass="6485" checksum="2C58947ED9EC6850" modified="2011-11-16" version="1">MSRLPTISSSSKIINVARFQYFQTFMLRKITFNLKNLAYRVGIFGVLYIDYIEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWG9</accession>
    <name>G3AWG9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112257</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683797.1">
        <property type="nucleotide sequence ID" value="XM_006683734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWG9"/>
    <dbReference type="GeneID" id="18246430"/>
    <dbReference type="KEGG" id="cten:18246430"/>
    <dbReference type="HOGENOM" id="CLU_1467958_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="184" mass="21744" checksum="0E3FB1CD697F751E" modified="2011-11-16" version="1">MADFRISKILDNVPASALRARDDSRDDVLNFIDYSDKFVSQFDKYRYVIHTDSDEFQSLNNHMMGESREPQSLQWFHRAVTRISDQVRLVAQILRRHKIYTIYSLETKFGEFLVVVDVGVDLPVMELTQWISEFQTMKFRNKRSWCDNLDYFHTVKFIVLGEDVGRSCDELINTEDTIDVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWM2</accession>
    <name>G3AWM2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112287</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWM2"/>
    <dbReference type="STRING" id="590646.G3AWM2"/>
    <dbReference type="GeneID" id="18246448"/>
    <dbReference type="KEGG" id="cten:18246448"/>
    <dbReference type="eggNOG" id="KOG1688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074889_0_0_1"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="191" mass="22924" checksum="D44AA5A6CFC22D7F" modified="2011-11-16" version="1">MENVLDQVKDTKVYQEYQKLGVTYQKLIDQSVPHKYYRWGLFGGVLFIFMVRILVSQGWYIICYALGIYLLNMLLAFLTPKFDPSLEQERRSESIEEGLGEDDDPAENEEEFRPFIRRLPEFKFWYNSTRAVILALITSFFSIFDIPVFWPILLMYFIILFTLTMRKQIQHMIKYKYLPFDFGKAKYKPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWZ4</accession>
    <name>G3AWZ4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="3 15">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 15">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 15">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_96658</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3 15"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWZ4"/>
    <dbReference type="STRING" id="590646.G3AWZ4"/>
    <dbReference type="eggNOG" id="KOG1975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020346_2_0_1"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 20" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 15 17" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="19">
        <location>
            <begin position="127"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="17">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV66649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="435" mass="50414" checksum="68DED1C878AD7C4E" modified="2011-11-16" version="1">MYKQQAELPAWMKKGQENKYDRYGARPSAPTAPEAESNDKYSKYRVNEDDRANRIRREGTAKRDRDRSEEPEVLAYKNLKVTNPANSYYQTFQSNLKRDEKDVNSIIRTHYNQRTYQSKYQGNRTKSPIIKLRNFNNIIKYILLGEFCKPVAAGEGPFRVLDLCCGKGGDLNKMEFIKVDEYVGIDISDASIREAYSRYEKNKVRFKSNFGGGSHRDSRKYNFQSFFATGDLFNYSIPDILEPNFPGIIDNVFPVDAVSNQFSLHYAFETEDKIRCLINNVAKSLKTGGKFVGTIPSSDFIKYKVKKEMRPEDTTFAFGNELYQVKFHEKPPADGDFNTSPFGNGYNYSLTDAIDDVPEYVVPFETLRRICEDNSLVLKVKKDFIEFFNKEIPKYFKRLNNNLIQSIKRSDGKYGIEGLEREAIEFYLLFVFEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX97</accession>
    <name>G3AX97_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_129076</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX97"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_0_1"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="72"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="530" mass="60940" checksum="C0F74E0B6A94AC58" modified="2011-11-16" version="1">MAESKGVDVTETNSVDSQISSKIYEPTDVENPEVARKYYPTVNWENFKAFDPYFRWTNYEDRQATRQTDLKIFSVVALLFFALNLDRGNLSSAVAGGLLVDLEMTTNDYNLGNNLRSIGFIISEIPSQLIGKRFGPDWWIPLQVIAWSIVSIFQFFINGKRSYWALRFLLGLAQGGFIADAVQYLSYFYTRDQMGIRLALFWVTDSYSGIISNLLAIAFLKIDLNGVESWKWLFLFDGIITLALGILSFFIMVPGPTQTKTRFIPKGLFTEKQEKIIANRLLRDDPSKSDMHNREAVTVKQFFKTLSDYDLWPLLILSLVFEIPQNPIKAYLNINLKALNFTTDQIIYLNIPIEVFVGITLIAITSLSEWLNERALVSLLPQIWLLIFIIIEYTSVEKLSPWSQYAIEFFVLSTPSAQAIIVSWCSRVSYSVRARAISAPMSNIGIQLAGIIGNNIYRADDAPYYKRGNRVLIGIAAMNIVLFILTKLYYIWRNKTKREKWNSFTEEEKEDYLAKHHDDGNKRLDYLFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXB3</accession>
    <name>G3AXB3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_100444</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXB3"/>
    <dbReference type="STRING" id="590646.G3AXB3"/>
    <dbReference type="GeneID" id="18245380"/>
    <dbReference type="KEGG" id="cten:18245380"/>
    <dbReference type="eggNOG" id="KOG0700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021928_3_2_1"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="169"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="585" mass="65537" checksum="62E0B0DE5FFAE6BB" modified="2011-11-16" version="1">MVYVLSIKPRLLYVASRSLQNSRRMISSSPYRLIKSTNPLLTTTTRVKPQARNGNKHFKKRNAALVSGFIIVGSFVTFNQSNYYNLDTIPPSASKKLFPSRSSTSAVPPEDKNLYTSSNSSISTNYSLGHQQHKEGVFVLNEEQVSEKLRQFEESYFVNRGKGVTRYDVCQLASNSPVEDDRSEEIVQVPILQDNNVKTSTDWMFFGVFDGHGGWTTSSKLRDQLISHVVAEFGTIFKPANEDNLRFVPNGATIDQAIKNGFLKLDHEIVNKNMEKLLNENNKAQAAELLMPALSGSCALLSFYDTNSQTLKVAVTGDSRAILGSFKDNRWTVRQLSIDQTGSNPTEVARIISEHPDESNVVKNGRVLGTLEPTRAFGDCRYKLPASIQQRIYKQFFGRSLPHNLKSPPYVTAEPVVTTTKINPDQNDFLVMASDGLYEMLSNEEIVGLVVKWMENQKMIKPKHSFWNYFGSNENKLPEVQDITNDKTSKKPFRKTRPVSGNNYLLDDKNVSTHLIRNALSNGGSRDQTSMLISIPSPISRRYRDDLTVTVVFFGKDPKGEDDLGKLEINPEATAGGIDASKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXI7</accession>
    <name>G3AXI7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112123</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXI7"/>
    <dbReference type="STRING" id="590646.G3AXI7"/>
    <dbReference type="GeneID" id="18246365"/>
    <dbReference type="KEGG" id="cten:18246365"/>
    <dbReference type="eggNOG" id="KOG1567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035339_0_1_1"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="423" mass="48139" checksum="3EC3F77DE195B1CA" modified="2011-11-16" version="1">MSVQETPTKGLTGQISNLGMATPKGASLTDKLAAEAEAKDVAQTVFTSKDLAALKERELQPIKVSPEETKKSLEKHNAFLRKHQVHRHELKALEKDEPLLVENTKRFVLFPIKYHEIWQMYKKAEASFWTAEEIDLGKDTHDWNNRLNDNERFFVSRILAFFAASDGIVNENLVENFSAEVQVPEAKCFYGFQIMMENIHSETYSLLIDSYIKDPKEADFLFNAIETIPQIKRKADWALRWINDSDALFGERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELICRDEGLHTDFACLLFSHLQNRPNPEIVEQIITEAVAIEKEYFTDALPISLLGMNCTLMCQYVEFVADRLLVALGNEKVYNTTNPFDFMENISLAGKTNFFEKRVSDYQKAGVMASTSTTEVKTESGFTFDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXR3</accession>
    <name>G3AXR3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Factor arrest protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_133084</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXR3"/>
    <dbReference type="STRING" id="590646.G3AXR3"/>
    <dbReference type="GeneID" id="18249667"/>
    <dbReference type="KEGG" id="cten:18249667"/>
    <dbReference type="eggNOG" id="KOG3680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003184_1_0_1"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="1">
        <location>
            <begin position="67"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="2">
        <location>
            <begin position="460"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="893" mass="103982" checksum="82E9F2B6CF5350B3" modified="2011-11-16" version="1">MQEELLSIDRLEDQLIDHPDATTKHDLNGDTLDETFQRKLNARAEQLASQGSQDPDDKGTLQRLINKTELKYTYRDYGSLENELNDWFVAHDFKVIDLDGLNARYTEGLQRFESQFQHIEDEVEIEYLKHCVESLTQDEICGSSLDTLIYYGFGKFKSCTGVCEQVHQIRDNVKVLYSLGVVEGVCHQINLFIDERINADDSGSDQLTDDTNYFKALTILYFMVNTFLQCSDSPTYLSFRTDMNDIDLMSSIVSFIQHWKVNPNGNYRIRHLIILLWKLILLEFGGSETLQSCDKFLIKYHNIKSKDNKLNKLTCSPLDYYTFRQDLVDKYPLFGELTSIKTDPYDFKQFGKTLDEINGNPRAPNPSSSSSSLREDYDFFMALNSQSSSLSNYIAHPRTNGVHTTQRQLPAQTVHISTPVPSPPSTPSDFMSGGEKIRKSYQINQSMPFIYPLSDEVEVPYAVKEADEILRDSIYDSYSNKRLWAERQKFMVQERGYLNNYEEEVSESQSDEFEYNMDDLLKKYPSNVLEIKSFMRVEKFYGKNLDKLSSLMEVLIGTIRSYKIEHNLHFIEDELNGETPYYANDKELMNNDKKTQIDKILIQQLEVLRTKEITAKASSGIICLLLKWFKINHVLKYYYLTTILFDSQVCTVAMDFLTETFNNPNNRETTNGHELENAYDSMIYQNQLTNPAIAIPMLNFFNQCLGNSKPHRFHLINKKKLTEFGTKLTENNVNKFVIDEVNENHCFIMINLVNIIHKVILKNHTQRILTVNELKPSEIFKMIVVNFDNPHLTIPILKILKQLIPYQGRKWKSLNMDLISMVYLNCRLSMRDTWLSGKDVENDFHNSFDQEISLRGLLQFYNMRKYPEKMRCLGYEVAPEFTSFPSDENFDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXT7</accession>
    <name>G3AXT7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_129167</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXT7"/>
    <dbReference type="STRING" id="590646.G3AXT7"/>
    <dbReference type="MEROPS" id="C19.087"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_11_2_1"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="166"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="481" mass="55645" checksum="E8A8058C42CCF554" modified="2011-11-16" version="1">MFEDLGSCQHIRQVLNSKARENVLITYKQAIKIALLVNKSNNFRLLKDNSSFSADKLIELKLNALKCSNCKLCNFNNNLICLQCPNIGCQINNHGYNHYKLNQHVFAIDSENGLIYCFKCNTYINDKALNDIRNEVRPESSLELPESDDTSDHYDTPEETSIRGLKGFVNFGSTCFISSILQTLIHNPMLKREFFNSDEHYFNCDVSECITCSIDKIFTEFFTSSNNDSFGMTNLLINSWYKNKSLTGYEEQDAHEFWQYLLNEFHKDHMRLKSDMGENDVFGHTYEDCDCITHKHFAGELESLIMCSDCDNTTRTIDPIMDLSLELTNLPDHSTVYDCLNLFTKEETLENYKCQFCNKNSKPKKSLKINKMSSVLSIQLKRFKHNVNSFIKNDIPIRNPLYLNLSDYLSQDSNEGSTNQFYELFALVVHIGSVNTGHYVVLIKTENNQWLKFDDSIITLVPQQEIESINAYLLFYMVHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY34</accession>
    <name>G3AY34_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112621</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684334.1">
        <property type="nucleotide sequence ID" value="XM_006684271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY34"/>
    <dbReference type="GeneID" id="18246608"/>
    <dbReference type="KEGG" id="cten:18246608"/>
    <dbReference type="HOGENOM" id="CLU_879978_0_0_1"/>
    <dbReference type="OrthoDB" id="4082216at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="226"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="316" mass="35797" checksum="D57B4945EB9423A7" modified="2011-11-16" version="1">MSVLEAISSSATEVEKFNRIKLISKALSHEELVNEVCTLSEAGLPDLDTDLWNCALSLCIIENKLESNELDSVGSLLSDVGTVINKHQGLTQDMPHLFKIVKFKHVDLNSDYQILFNVISKNYKLVELVNKKIVLLTIKDYSGIDKSFKEELVSKTIDLLIVSPYDFRKVDLVKFISSYVNEHGLDVKLSPLTEELFLMLTTNNIVNIEKFRKYTEQAPTKVIQHLDARQISANLVENSLFVLSNFYKSIYFSKLSKLLGVEVDHIVISKMIVNNNLPLNTKIDQVNEVLTFPDSTTNTFVETLNMVQHISNKLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYA9</accession>
    <name>G3AYA9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_118534</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYA9"/>
    <dbReference type="STRING" id="590646.G3AYA9"/>
    <dbReference type="eggNOG" id="ENOG502QZSN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012844_0_0_1"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF88">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1002" mass="116261" checksum="D62D71D15B6DBCFA" modified="2011-11-16" version="1">MLATSEINISQAKKAPDVHVKILADGKVLKVQKTRQRRILSCIHCHSKKIKCSRAVPTCDHCQKLGIDCQYFVNERISKGGKRKKKSRSSFQNGSAASNSTSDTSSISREDSKILKQESSEMEMEMENSSKSSTNDHPQSQEMTIQDNKLMETLSSNFPNLPKSLLQTPVMNSMSNNMTNSYFSNTNGSTNANADHEKEDQYSFNLSSFTYASYQGSHPHTQSYNKLVNQDLHSSLSSHNNSSTNISSLFAKNPSHIYPQNSIMDHSKSHLHQNTQGPQTFRNPASPHYPNSASFEISERLDNTKNFLNGTNTYYDNENLLEDLENHLPTSKPKSYELVERYLNSVHILLPIITNIDDFVREHDKYWKECNPYEKETNNSLTDLNLLQFYTLYFPILYAATISEFEEYDNLLLNQDINKYLKGFNKICQYYNYPHGLKIIPLLLGNVIIQSTSPNPSTMEMSSIIRYAKFLQMNKDPVFSLNIKNYEIIKFRRLLWWTIFGLDCLTSHNFCLPPVCKFDDFNVVLPSDEEPIFNQANEIVGYTLNTSVLSLNIKFKYDRILNELVSQLHSDNSKNLSKEKMNEIKKMICEYFDYIHLSINKMNLYHKKFPPKTVGEVNLLNFIKNHSWSFVDRAVMLLHKKFLLNEHDSTVNKEPGSSSNSNASYTYSIDSYDVHLTKPRNGILSFNSFEDTFQSLVEENLIKNFVNFQNLNLGLDFNQFNNFSYNDINNNLIPSILHNLNDFLKYNDFLKFGKFNWYVKRTIPLDSIILLFIIIIVKFKFETIKFNELIIYVKLINKSLFILNRKWFKNEKYKRMLSLTNLTWEYILKKFKILHIINKFTSSNFSITSSNKNKIFNKYEYFNYQLTGYLNTTELFKTMQVAQPNLSMELINKLNNQKIKYISNTGTAAPDSPGINLNINSLVSKYDTDINLIESNDDFKIEKDFTINSSLTGTFHIDEDELVLLHDKICFDLKNNYVDINDYCAFYISLENILHQVINFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYK2</accession>
    <name>G3AYK2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_112740</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYK2"/>
    <dbReference type="GeneID" id="18246657"/>
    <dbReference type="KEGG" id="cten:18246657"/>
    <dbReference type="eggNOG" id="KOG0751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014931_1_0_1"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="327"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="421"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="529"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV65872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="720" mass="81311" checksum="6BE825955489A71A" modified="2011-11-16" version="1">MSISDLKAKEIFHQFASVNPDTREEYLSLPQFTTILSPFPTDVPKQSFSILYLIADANKKGYVTEGDFVKFISTLNDVDGEFKLIYKLFSNDTSSIEYNDCLSMLNKLNQAIDPAYQQKKFKINWAYFSKFFEPSGKIAYPEFITLINNLPFTKLIGSFELMVKNGTITTNDLISLLTQNLNHKLSSNLKNNLGNLPEFFKKDTFTFADVMFIYNCLSKIDLINEVIANTPANSSNEKNDILINKRDLYTHLKDPLLKSSNFKPVAMNELDLLFYLINQHEETVTRKDLINFLNPNYANNIKTLYSIFEHPASIPVQKDNFSLLPIFDSLYSFFLGSIAGCIGATVVYPIDLVKTRMQAQKHKALYDNSIDCFKKIIKNEGFKGLYSGLAAQLVGVAPEKAIKLTVNDLIRGIGTDEKGKITMPWEVLAGSSAGACQVIFTNPLEIVKIRLQMQGGQRNKVLKPGEIPHKQLTAGQIIKQLGVKGLYKGASACLLRDVPFSAIYFPTYANIKKHIFNFDPEDVNKKQNLNTFELLISGAMAGAPAAFFTTPADVIKTRLQMERKSNEVKYSGITHAFRVILKEEGLSAFFKGSLARVFRSSPQFGFTLASYELLQRMFPLNPPNTKSSNFKTITGYPGIYNLTNEQVYNNQTGRIMYINQGNLMKSNGLINENNEDYNNVLVKIPTDYVYKSQDAIKILLDIDYKFGNFNYQSYLSFVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYU5</accession>
    <name>G3AYU5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CLU1</name>
        <name evidence="2" type="synonym">TIF31</name>
        <name evidence="5" type="ORF">CANTEDRAFT_97005</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684505.1">
        <property type="nucleotide sequence ID" value="XM_006684442.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AYU5"/>
    <dbReference type="GeneID" id="18250648"/>
    <dbReference type="KEGG" id="cten:18250648"/>
    <dbReference type="eggNOG" id="KOG1839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003256_2_0_1"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="345"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1227"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1233"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1283" mass="145590" checksum="0A15F3ACA7DB7E47" modified="2011-11-16" version="1">MSEENQLETVQTLKLQLSLPQCLSTKKETVEIETTLDETLPQLKETLGLIPKTENLTNLLIFYKDVNLFEAFDEMSTFRDVLKQLGLEGSQSLSLRLAEKPYNLANVYEHLLKFRQVIGLHFLDKSKMDFGVSGGVSKFSELGLDAITTPQVPKEPEQAESTKSKESTKKEEEEEEEIVLSSEQKAEANKLAESLSKSGGVDILSLGSFQNPFKDFKLPIKHLTISQWSPVPQYQKIQGDLLYLSLQTLENETFQITAHFSGFFVNKSSSTTFNPQIKHSMKSNKHFILFDLISGLSPLFEKTLIANSSNLHSSSSNPETYLIPTSSFVNHPWLVGKENITNNADLTQNQLPILVSGVDGGELVRDWNDEFQSIKELPRSTVNERILREKLISKTIYEFNKVATETAINIVNGNITSLNISEDPELLTFLRNGVFYSFGVDATGNFVNSGGDDAARYTTGKDLNAVKILNRIDSSDVHNLLTLVVDYMGKRIICQAPVPGIFQETRNIETDEVFDKVVYGLNSDNSQIVYNKNFNDALKTISEAFHLKPHSIELDDGVKSKELLITSKDMKGIHGTDGRKYMIDLYRTTPLDIGFIEKHFQPEKDTSYPHKETLVRHEALEEWWKRKIAVLIKLETEKLEKEGKTFDKENGEKPQLLIQGDQVSINSDAFTGINESEEDRNDVREVSKFVLTLVEEFLNEMGTQLAPFDGSHLTSMLHRSGINLRYLGYIADQCLERKQKELQKIEEQIKSNEALAEQLAQEEKEKVAKGEEQKEEENLEETKEEEKSAGIYEPIAANYETIYKLSVQEMVARATKHVLRKLSKSLPVNLMSTFVSHFLNCLLGSNISVSPMCFIDENLKTFYSFKDLQFTSLTSNDAIELVTKEVFIRFRFQLPSDWVNTLIKPYQLFREISLKFGIQWKAQNYSFTKEEFELNKESMVIEAQVIENNVVSKKNKKGKKQSSPVIEKVITRQSIFIADDILNFSPLVKDSSYKPALFDEVLETARIELKNDQQNGLMLFNELLSFHEQVYGRVHTETSSYYGYLSQLYSELNFPYEASTLARVSCILSERVTGFDSYNSITAYVNSAFFESSNKDYINSLKLYSHAIRIWTSIYGEDHPSFITTFANLGEIFTKLKLFDASKKLFEKSIELSTKLNGEISDVTGLIKYRYGYSLLSADSFKGAKVQFENSYNIFVKALGPKDLFTVKSLSYATNLKTWLDYQNHEKSKKQSASKAKAPASTAASKSKKNKKNQNAPKIDEEIASKSVDDIMAFIEGSNKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ63</accession>
    <name>G3AZ63_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_119083</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ63"/>
    <dbReference type="STRING" id="590646.G3AZ63"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018982_1_0_1"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="225"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="667" mass="72706" checksum="8AF0736EC6A7860E" modified="2011-11-16" version="1">MPKKSANTSKQASLFDIRLKNHEHDVLILKGPPDDAASALLSGKIVLSVNEPFAIKKLNLELYAMLRLSFTDSVITTKGSYPKNVRHERKIYDYHWDNSEINKYLNNMYENSGLSAGINGPGSALARTSSTTSSSSLAALGSQRLTNYTLVKGNYEIPFSAILPGSIPESVEGLPGASVVYHLVATIDRGKFHSPMVAKKHLRVVRTLTTDSVELSETVAVDNTWPKKVEYSLTVPSKAIAVGSGTPISMMLVPLLKGLRLGEIKIALVEYYSYIGYVPPVKNVERNITEKVIPRPSEDDSNFQLDKWELQTFLTVPPSLSKCCQDCDILTNIKVRHKIKFTIGLVNPDGHVSELRASLPVSLFISPFVTVRSGVDDEVSDGDTAIRSNSSSYTDFSGLVAPPIYEQHIYDRLWSDVSPIESPITSGSVTPREIPAPLTAVQDFNMSPIDSVQLNENLRLLSLQRQSQESGTSTPTPLATPTPERATFSLDEEGDYFAQRRPPLSSNNVLMSPGAFSPVHLSRTQSESVLNISQVPSYHEAIRQPDEEELSPAYEPPLPGSKINLDEANKTFEQTTRSSRPGSGTVSPVSPLPSNLPRPGAQRRSSSSGCSDFSAPDASSQSTVSVAMPSSRASDRTAVLGGSVPIRSSSSLSLHNVHFLNKKKDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ88</accession>
    <name>G3AZ88_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDHD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_129460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ88"/>
    <dbReference type="STRING" id="590646.G3AZ88"/>
    <dbReference type="GeneID" id="18249383"/>
    <dbReference type="KEGG" id="cten:18249383"/>
    <dbReference type="eggNOG" id="KOG2308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007365_0_0_1"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055555">
        <property type="entry name" value="PA-PLA1_DUF7131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23465">
        <property type="entry name" value="DUF7131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="1">
        <location>
            <begin position="534"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="760" mass="87218" checksum="4259215EEF335FF4" modified="2011-11-16" version="1">MRPESHTKGVGFDKGCETFESLEITSLYAIFKPTPILTKPRSTLLSASVSLSFPPTKAQILFGWIKWYYATDVPLTKPDWYEYKKTQDAKKYVPFSDYDSKRIESHYRKFGDSQSEDISPRVYVSEDRLFQVDVENLHLSPVYWEGPSYETRRGLWFSSDGIPLAEDITREIENGYKDKKPYLFDEDRKRQAEQPQKQKPNNIDFSKFYETIGEDFKSKESHDDVVILGNGKAVVYFNDNKAVLFPKFMVNSYQLPIIRQFYGSSVALMGVEPIQRGYSSDLKSMFDNFTKKNTISSSNHFLLPEPGLFLGKIPQNKEDNQNEQMREVIEDDFEDSTTEQTSTRETDHLVLCVHGIGQGLGLMAEAINIVHDINSMRNTMKTVYKENKKFRNLAYKDPKDPDVDKNNRIQVLPIAWRHRIDFHPEKVSTSDDKLEPRLPTLSQINVEGVRPLRNVVGYVALDILLYYDNKYFNQILEAVTLELNRVYELYMENNPDFKGKVHILGHSLGSAISFDIASRQFDTRPTKPNRSADLLFDVDSLFCVGSPVGVFKLISQKNIVNRSDVPKDFDPRSRSLSYSSPKCKNLYNLYHPCDPIGYRIEPLIKPRFAHFKAQEAPFAADGLETPFKGWSTLTDELQERFSKANTWLWSFNKKSKAFDQNSLGDFMNGIVDSNPVETPDDAESKKKLSQKDLGELLKFNKEGRVDFSLPRGMFDISLLSAISAHVSYFEDKDTAGFIMGELLLSDNPPVKSLEVMYKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZI1</accession>
    <name>G3AZI1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_117968</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684157.1">
        <property type="nucleotide sequence ID" value="XM_006684094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZI1"/>
    <dbReference type="STRING" id="590646.G3AZI1"/>
    <dbReference type="GeneID" id="18248614"/>
    <dbReference type="KEGG" id="cten:18248614"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020753_0_0_1"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="127"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="508" mass="58711" checksum="CC9CD0740EEE0C1A" modified="2011-11-16" version="1">MSDYESLLEFEDSLQTSTQKDTSITLGNLEAKIEYNLVVPSDHSTTSPEIALEAIFNGYDYSMDEFTSCNICGKPINTNSDCCLKFIEQSKLSSSLESSYWRLFLNSPTRTINTLPHYSQLLFLEQGIPFQLRPTVWKKLFLIHYNNEIPEACLLVYKNFQHSYNSETSDQISKDLNRTFPTVSFFLDERNIKQLETVLNVYANYDVELGYCQGLLFLVGTLFYQFKDPQLTFHSLITIMESEVELHDIFTQELMSSTLNKWYSEFTGMLSKLDNELYVHMSSFVDMKVFLYQWWLSFMSSHTPDFSIINRILDFCLIQGWKIGMFKISAGLLLVNKPILMSLTDGEEEVVYQHLLYECKWGLALKDINHFFGELLMNFDPSFFNKNEDMLHINKPMKTHKRTQSSMIDKFRSLNISSYSLGNTSNNSIFSKKIYTTVNNDTDSVYSEVTIDSSSSGNSKFADYLKIPSPFANSEISRQNKTMKDLLIKCMANLDDEELIKEIIQVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZY4</accession>
    <name>G3AZY4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113009</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685168.1">
        <property type="nucleotide sequence ID" value="XM_006685105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZY4"/>
    <dbReference type="GeneID" id="18246780"/>
    <dbReference type="KEGG" id="cten:18246780"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="336" mass="38449" checksum="1ED01E2ED6EC8107" modified="2011-11-16" version="1">MLDLDYIESLPYVNPTVDRRTVLILGGCSGIGWYTVLYLFLHGYVVYITGRSKSRVLKCIDELEKEAIHIRRTYTSHELSSERYLGHLRYLELDPSSLTSVLHTSSAFAKLEDHLNIFINNLSTSQLPPTLTQDNFEISLQLNYIAPFLLITQLLPLLENTSLHSHLDPPKIIYTSTPLHRLQLSYWSLDTTWPTYAHTVFGWFRYCNAKVSGIHMVKMLGLRNPKILSIAVDTGFVMNPNSFSFLTRLPIIGVMFWCLFQVFGYFFGSSVEEGSYAIIKTCLDPTLDLEHDNGKYFDSRGFDSSPSRVAGDMDYAARTWIWTVNKLNERGIHIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0B1</accession>
    <name>G3B0B1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113075</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0B1"/>
    <dbReference type="HOGENOM" id="CLU_2757548_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="70" mass="8152" checksum="776361B7600BC6AA" modified="2011-11-16" version="1">MPKRRKQRPADILTTSRSQDSAIPLPKRQKSERMDFESDLTDFEEDVSEQKLQVLNLESYRVSSASHENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0D7</accession>
    <name>G3B0D7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metacaspase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113100</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell death (apoptosis).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0D7"/>
    <dbReference type="STRING" id="590646.G3B0D7"/>
    <dbReference type="GeneID" id="18246823"/>
    <dbReference type="KEGG" id="cten:18246823"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029389_3_1_1"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="9">
        <location>
            <begin position="84"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="379" mass="41881" checksum="F1F7C5A4402B1CD5" modified="2011-11-16" version="1">MFPGSGQHSYGGRPQQYQQSNNYGPPQGAPPSGYGQQQYSRPSNPPPPQSQQYARGQLSAPSTAPQQFNSQVNAQFSYSNCSGRRKALLVGVNYFGTNNELKGCINDVKNMSSFLNKQFGYSWDDMVILTDDQRQYNKIPTRENILRGMQWLTRDARPNDSLFFHYSGHGGVTKDLDGDEEDGTDQVIYPLDFEQNGFIVDDIMHEIMVRPLPMGCRLTALYDSCHSGTALDLPYVYSTKGVVKEPSILKDVGGDALSAVLSYERGNVGGMLSSLGKMAKTVMNQGSFDEDKVRQMKASPADVISLSGSKDDQTSADASFNGSASGAMSYAFISILSQFPEQSYLSLLNRMRDFLKAKYSQKPQLSSSHPIDMNLKFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0H7</accession>
    <name>G3B0H7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_119767</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685090.1">
        <property type="nucleotide sequence ID" value="XM_006685027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0H7"/>
    <dbReference type="STRING" id="590646.G3B0H7"/>
    <dbReference type="GeneID" id="18248727"/>
    <dbReference type="KEGG" id="cten:18248727"/>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022620_4_2_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="103"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="375" mass="43556" checksum="53B528A4354B940E" modified="2011-11-16" version="1">MTSKDNDGSERKSSRVSTDDLYRRSTQFKLWSFTKDELETIRKSSNEKGKTYANAKFDKVYERIKAEQTDIFSKYGGAELSKNVLVDLITLQEERKYLNFYSKNIIQAANFFQMPTQVKASAMAFFKRFYLFNSVMQYHPKYVLYTCLFLAAKSENYFISINSFCEPLQKTEPKDVLDLEFIVLQSLKFTIMVHHPFRPLYGFFLDFQEVLLQPSPASSDITIDKIGQLYDQAKKWLNDHGLISDVSFFYTPPQIALAAMYDSNPRITEKYLRRKFLKDKEPLNTIKEEEPDGVDAQQKDSLPPKGTEVFDLLVKTIRKCVEDSKTSQESTLEESTKIGEKCFFANNPEKLINKKIKKLKKLEAQEQESPQEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0Q9</accession>
    <name>G3B0Q9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_102630</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685138.1">
        <property type="nucleotide sequence ID" value="XM_006685075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0Q9"/>
    <dbReference type="STRING" id="590646.G3B0Q9"/>
    <dbReference type="GeneID" id="18245566"/>
    <dbReference type="KEGG" id="cten:18245566"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_6G13830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="269" mass="29283" checksum="A4883E0A668CD747" modified="2011-11-16" version="1">MLYKNQDAPVLSLFSLKGKVSLITGGSRGIGLAAAIGLAEAGSDVAITYNSSSPSYVKELESQFKNLGVMFKTYRCNVAIKADNDKCVAQVLNDFGRLDVVVPNAGICIHVPAEENTEEQYREVMGVNLDGAYFTAQAAANAFKKQKEQGILEQGRIVFTASVSSGVVNYPQKQAVYNASKAGLVRLAKCLAVEWVDFARVNCVSPGFIDTEMLDVHPKEWRKTWFNMIPAKRLCAPYELKGVYVFIASDASSYMTGEEVFVGGGYTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0T7</accession>
    <name>G3B0T7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_113571</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0T7"/>
    <dbReference type="STRING" id="590646.G3B0T7"/>
    <dbReference type="GeneID" id="18247025"/>
    <dbReference type="KEGG" id="cten:18247025"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="32"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="485" mass="53410" checksum="DC77756AE9BC17F0" modified="2011-11-16" version="1">MLSSTIRSTLRVSSRYYALSAHAKALMSKPVSEIDPEMTEILGLEKQRQKNSVTLIPSENFTSKAVMDLLGSEMQNKYSEGYPGERYYGGNQFIDQAEALCQKRALEAFDLDPEQWGVNVQPLSGAPANLYAYSAVLEVGDRIMGLDLPHGGHLSHGYQTPTAKISYISKYFQTMPYRLNEETGLIDYDTLEANAILFRPKVIVAGASAYSRVIDYARMKKIADKVGAYLLSDMAHISGLVSAGVTQSPFPYSDIVTTTTHKSLRGPRGAMIFFRKGIRKVTKKGKEIPYDLDKKINFSVFPAHQGGPHNHTISALAVALKQTSYPEYKEYQQNVVDNAAKFADQLQAKGFKLVSDGTDTHLILVDLRSKNIDGARVEAVLERINIAANKNTVPGDKSALFPSGLRVGTPAMTTRGFGEEEFGKVAEYFQRAVDISIDLKAQESGKNPKELLASFKQLADASKDVKELGEEVSNWVGQYPVPGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0Y3</accession>
    <name>G3B0Y3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113598</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685947.1">
        <property type="nucleotide sequence ID" value="XM_006685884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0Y3"/>
    <dbReference type="KEGG" id="cten:90982304"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="4096546at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="251" mass="26557" checksum="98FDB326C9E1C1E4" modified="2011-11-16" version="1">MSSQTTYFITGTNRGIGLAYVEHLTSDKSNLVIATVRSEKAAGPLTALNRDNLKIIYLDMADSSAKFEAAFKQLEHLAPNGIDVFIQNAGISGPKFLVPAEQYNAESYAEVLTINVGGSAKAYNALYPYLFKGTGTKKIVFLSTIAAQIGFPAGGNAYSASKAAVNHLAVQIAKQNAGAENELVRNSATVMLHPGLVETDMAEEPKAVWGSAGFISPSESVEKSLKVVAGLTAADTGKFLSYEGDELPFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B102</accession>
    <name>G3B102_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113613</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B102"/>
    <dbReference type="eggNOG" id="ENOG502S8GG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076653_0_0_1"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.310">
        <property type="entry name" value="Protein HRI1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26156" checksum="E205C6D7C08367D9" modified="2011-11-16" version="1" fragment="single">MVIYSKGEHFVDIRVFKDHYPVIEENPRSLKQFTDTFEWTMTGDEIPMEAAIPDTYVLSFTHEIDSLAVVKSIEENIPVEQCLSEPDVGTFWKLPDSEDRKETGNMTNPATGKKGDYVEIWRSLSALNATPSEDVRETPHDIANDKNLHVLRVLDNEQFEGQFIRSGAWCQGLLYDKLNKIVPLNVVRGYFDGEKWQWLIKYGSFNFPVLFSGSIGDTIDINGVVWSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1V1</accession>
    <name>G3B1V1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_92769</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1V1"/>
    <dbReference type="STRING" id="590646.G3B1V1"/>
    <dbReference type="GeneID" id="18250228"/>
    <dbReference type="KEGG" id="cten:18250228"/>
    <dbReference type="eggNOG" id="ENOG502RPVY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539235_0_0_1"/>
    <dbReference type="OrthoDB" id="4095887at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="573" mass="66817" checksum="9DB2620CC863F699" modified="2011-11-16" version="1">MLFKTCTRSLSRIRHRRVIHLSHGITDWADDKLKVNAKQEEKYRKRLATDVAKHNHRKHIAQQYQIHLRNIKDEDPLITFQPKKIQEVPLSGLEQLEKLDLSYAHTIQGTVMAIIDETLATLLVEMNLRRHLVGDVVDSRILVKSISGFGKEDIPQDIDLEVFMDSLGKTIEFSSLEEFRLVYSYYKSGNYLNYETSEMSRFVKGFRNGYQSRFSSDSLIPRINELFNNFNNKQDQISRVSFMLSFVVELIKATEPPSMKVFRHILDHMNNCDLLAYQLIIMRHLTPIKFKSSALADSQSPKLTALQYKELIEEEPELVNTLFNYYDKIDSDETIEQLLSYLKLEEVLELEILCSGSIYNQLISKSSFLKSRSSDLNQLEIVSYDTPQQMILSRDTMKNIIGICIKHKKYKYIDFLINKILLQSNEDGVLLMLNDDPQLIFNLDQMEKVLLNVFDKELMLLIIKVINESNDRGRLMWLLPNLDLFLKHYLSAHREGKKLQKVYETFRNGVFDSDFLQAEKVLGVNLKLVFNIYNCLRIHTSDTTVAYYEKLIGIPAPTDSVSMDPLFRNYFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1V6</accession>
    <name>G3B1V6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113310</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1V6"/>
    <dbReference type="STRING" id="590646.G3B1V6"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001406">
        <property type="term" value="F:glycerophosphodiester transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="503" mass="55178" checksum="35D61C1640642CB5" modified="2011-11-16" version="1">MSVDKTNEVVIEDITHSDSLGNQPHLDHYIYNAEERKARLTKPHWKDIMSIVCAGFALISDGYQNNVLTMVNQVLTQEFPKEYTADMKTNVSNAGLITTIFGQVIIGIYADYIGRKNAIVVATVFLVVGTCLCAASHGNSVNGLLWMLIISRGVTGFGIGAEYPSCSVSANEAANESVKKRGGIFVLVTNLPLSLGGPFALIIFLIVYQITSHYEGIWRTMFAIGAFWPLSVFYFRMKMATSELYKKSAIKKNIPYWLAIKFYWKRLIGTCVCWFLYDFVTFPNGIFSAGIISSILIGPDASNLEKIAEWTLLLGSIAIPGCFIGAYLCDVIGRKYTLMTGFLGYIVFGLIVGIGYDKISKIVPLFVVFYGLMQSCGNLGPGNMLGLISSECYATPVRGTFYGFSAAIGKVGAVVGTKTFTPIQNNVHLGKKWTFIIAAICGLVGVVCAFVFVPHLKEDDLLEEDIKFKNYLRDNGWTGDFGNGEQVDDYDAASSESALSNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B276</accession>
    <name>G3B276_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_113391</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B276"/>
    <dbReference type="STRING" id="590646.G3B276"/>
    <dbReference type="GeneID" id="18246935"/>
    <dbReference type="KEGG" id="cten:18246935"/>
    <dbReference type="eggNOG" id="ENOG502S1B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068297_2_0_1"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="195" mass="21958" checksum="E2466E70298B30C4" modified="2011-11-16" version="1">MLKYRGIGINSVGVSRGLSAWRLKTPSYTVPRLSRFNSTSTQPSASLNWVEYFNLKKQNNRINLASSVITGALGGLLTLNYLGNIEIDVEKPIMGFDPFIVMGGAVVVGSGIGYLLGPFLGTPFFGLLNRASLNQYKIKDQLFLQRIKLKRVDPSSQSFSNPVPDYYGERIYSLNNYKQWLRDCNAFRRKSKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2R5</accession>
    <name>G3B2R5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FMP27 GFWDK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_120679</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685547.1">
        <property type="nucleotide sequence ID" value="XM_006685484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18248794"/>
    <dbReference type="KEGG" id="cten:18248794"/>
    <dbReference type="eggNOG" id="KOG1910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000741_0_0_1"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1151"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1548"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2337"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2378"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2555"/>
            <end position="2632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2338"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2386"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2412"/>
            <end position="2424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2425"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2555"/>
            <end position="2569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2570"/>
            <end position="2579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2586"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2611"/>
            <end position="2623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2632" mass="300857" checksum="924EE62E19C4490D" modified="2011-11-16" version="1">MSNVLYWALSILLVLYLAVLFAINRFPNITIKSLGFFSLRGIIIETPHKIIRIKRLRLRVNFFRGKDSPLKLFNLEVFGAEVKVLCNDKPNVVNEKLAKQAPFDLEKFLKLTLSKRIYEIIFYYSLLNQVHVLFYRCSVHHEEVDKNVRLHIDYAKLENTLRYDGHNSLTLLVFNGFLHELEDHDRIQIFRNVEVILGCDAIFNCSMNQADVMEASLTNFSLVVSLGKAHVPLDHVNFAPKVKGKDSQHHPISKEQIHILRQFWKIFSEARLSLEEFTLSSGPCLLQVATFQASLTHDFTEEVGKNPIAGFNIHVTSLKLFEAETKCFELPAVACNFEANPFGLLEGIENSHHEELIKEVCSSSDIKFNLTVTNPTVDLYHDQLIMLQIRNRTKQRKPQMTKVNFMNFLLALHKVSTKIVIVDTKIIIHLPAFGSNEFHREAKSNLILKYTVDSLVQRFVTTDLSKSLLEGKESKQQLFGLFKIKNFKANLLDNVINVSKCNLLAVYNINERDVSLKMNCKRLRMKSINSAIFHLVRDRRTKRIILDNQLYNDLMLVSKENNPSKCAAVDDGLYYELFEMLPPIINHLKVEVNEVHADMICKDGLPSQIYTDPATQQQYDLKDYGRGVSLKLNHASLKYKKDSEEVFFKVSELNCFTLSELDLDYVLDFDIVSAYSNGKDDFSDVSSLESIALAATEEDELRKVKQVFKISEVEINNISNKQRDKNRLSVRIPEIEGRVDIFFAWCSIYAISLIKAFKPTVERVCSKEKIKSMMGVTDKKLKLDIFVQVIAIVTRLANSVDVLTEFDTLLVRDALESKSLEFKYARCYLVHPTTKLWARFLTIKNSFVAVNAVIENEDAFEVACKGIRLNIPHGFLFYSVIDNVVTFGKAIKQISNNFKNFSKGVMDFGVLPQEARGAFHVPTVNIKTDNFAMTLENDPFENELSYILELGKVEQNLRTKKYQFFEKQAKVIMDNTLDSKIGLHFTDSPLSTNNVATNSKKQATPINLDSEISRSNTNDTHLLSDEEAKKRIEEALYILERELSTSWYYKFKKFRATKIQNWSKRLERGWGVEKVNDKITDKFDIMNYLPGPLLMGLIFKSLDLTVSKSTIPDLDKFLFEYGKGQPKLDYSILLPVHLLLKSAAVFAFLKDYSLPLLSFPANDDSTKPAFQLQGNMVINEKLVHRKEEMRQIWVPFSPPMAPKVNEDSFYFVSVTRTLTPVKFMVDLNCDIDTERAAMISWCKSYQGALSAAMSAVDNFTKPKIDDSPLGWWDKTALTLHGQMVFNIPNELCFHMKSSTNPYEMTGRNAGFVFCWKNNVVLKIDGVHSSKELITLNSDVFLLAVPNYSMAEKRSWSLFYDEVTEAVPDIESESKKFQKKVMSLSSDERVQWTLGLLFEGNQNHSSNLSDKEKRTNTFIPHYDVVVTGPNFDWHPDSYKGYRSEYIHLAISVKSVSRKGNSSNRIHLTPLTINYFLYWWHTITEAISLPIRQGPLFDDQLDETGQGNSSAKTSTHLFTVKYQLIFEPLTVSHMLMHSSGEKGNQVAFSGIKGKVGRCILDLHQRKEVLTYVNNKLDIKNQILHLKMNQAEIMFKEADVRIVNAIFPDRSMQSQLDRYLFGTSDSSSGDTSNDNSAQSSGQFLNWVSGLDIQGEDFSWLDQEDFTELEIREVLSPYPKVTILPFFFTPNFTYVREFSLQEEGPYPFGKEDSHNCELGNETPADTQGRLLSNRLDGIRSEIDINEDLLANLKGTEHQGEIDAAVADQILTIQKTIDEYKEKQDLVESLYERITGKIAPGEVSHDESSALSVSRYDSRQLSIYSSHKSYDEMKDVELLNKQASEFHNRFIIHNLQLKWGNKVRDLFMDYMQYGSEKKSEAYFMSKRAVDLVESVINTVPEAFKPTKEQDEFCTARLECEDVINAFDDYLEDIDSETQEAEYKFLVKLVSPQIQLISQKDPESTALVVSKDLELRIMSVNLKGVNKLINADNEISGTIETRYGGLFNEFSVYVFNKKDVVISHPNVPYGYVDSQLAVSWPPWVEYENIHEDCWMDKNLVAERTSMVLSFKKPNYLYIDTTSVPEKNEIQVHVAKFVLKANSQQYSTIYYIITDLLVSGKNEKSSLMNKLDKVVSVSDDDDFIGLDERVKTLQSTIREFHSILLKIDGKSLKLNELESAQLHQLELELEKRKLELSMIMRGLKLRNVKSSNKRASRAWLISIDQIIWHFLDSKNAPLIDLALAKSSFSRLDSVDGSNKNKVQVGIIQGFNLQESAVYPELLSPINSGKYQDSANPLILMTWKMLNPVGGIPIMQQAKLSIQPLKIQLDYTTAKLLFEYVFPKSDSPTSNNTPRPRNSIVRRQTSSDLSSFDMSMDKIERPKNIFRHFNKKGSPSSSTEDDSSSISSRSHSISTRFSSTEDLSLTNNTDNKPTTKEPGKKKDAEEGDDISLIVSRSSKFISIVDLEVEQFKLHISFKAPKHLNIIDVHNLMLNIPNIRYQNKTWSGEDFILRLRKDITRIILQHTGQIIGNKFKIRKRKLLKEPLKQISNYASFLSVQDLQNNGNNAGDRQTSTRNPHIHHHRHHLADHSQGEDSMSSQGSTSHHDGGISFENLLQEIIDEEEEGEDDDTTSDRNVSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2U2</accession>
    <name>G3B2U2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_93000</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2U2"/>
    <dbReference type="eggNOG" id="ENOG502QTZH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_2_0_1"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF2">
        <property type="entry name" value="ABR173CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="395" mass="42722" checksum="D3C2AB7B3547E4B9" modified="2011-11-16" version="1">MFSFGVTNQVMVLFLEEIGIEAADIGTFMTLTLVGDVSISYFLSWNADKIGRRAVLVAATVMMFGAGMVFATQSGFWVLLVAAIVGVISPSGDETGPFKTIEEASIAHLTPHNHRPEVFAFHGMFSTVGNAVGSLAGGLIVDFLNLTLEWDLISCYRAVFVAYALVAVAKFFLMVNLSERCEVRNGSEQSRLIENGSDESSEPSESHDAGSVDAGSTASVASRLLLVFFLDSLGYGFMPASWIVYYYKSMFGITATLLGALFFFTSLSNTVTTIPSAFLAKRFGPVRAILMTQAPSSVIFMLIAGCTNFTVAAGLLFIYYSTTAMDVVPRQILITSVVKKEALTRVMGTVNTVKTFARCVGPTFTGWFAANRMLNWCFVISGVFTLMCDGVLGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2U8</accession>
    <name>G3B2U8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_134078</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685572.1">
        <property type="nucleotide sequence ID" value="XM_006685509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2U8"/>
    <dbReference type="GeneID" id="18249764"/>
    <dbReference type="KEGG" id="cten:18249764"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="66671" checksum="16C3185ACDBA0FBE" modified="2011-11-16" version="1">MSTHSTHYTDASSGSSGVSNKRYQAYAPDTGSRASLESEKAADDDAESEILHRQRTNVSELSRIISGIRDDRIQDAAVAHEYRDTGVPDAVIAQELEAISRKNTTIADEEQVVGEKELKLSEVDVEEEENIPPPDEGYAWVIAIIAMLSVFATWGSNASFGVFLQYYIDANVFPGATKYDFALIGGLVVCLAQGCSPFVSMLYRVIGIKAITALGITLQTAGYILASFATKIWQLYVCQGVIVGMSFSMLFIPATLVLPTWFDKHRATAFGICISGAGSGGVVFSLSIHKVFEMTGNQRWGLRLAALMALVAALPCFLLKPRYGKTLPFKQRLSKQFIRDNFKLIFDFSVLSTWPMMVWCVWFSIAMTAYVVVLFSVSSYATSIGLSSSKATLLTAILNIGQIVGRPGFGFVADWAGRSNVAVLIPLLICIWILAFWINASSFAAMVPFCLILGGVAGIGTLMSQPVCSDILGDPSKLPAGWSAMNIAVSIPSLVAEVIALALTRSNSTQPYLHLQIFVGVCFFTCSTLALLIRSHLVNKVIRARLACSINTLQELTGSRCRYLTVAELQKTDEEKADIVLLTERIERYEVLLRASVGSFFIRMFYPIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Q7</accession>
    <name>G3B3Q7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114280</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flavodoxin-like protein (FLP) that plays a role in cell wall integrity, oxidative stress protection and virulence. FLPs act as NAD(P)H quinone oxidoreductases. Reduces ubiquinone (coenzyme Q), enabling it to serve as an antioxidant in the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Q7"/>
    <dbReference type="GeneID" id="18247352"/>
    <dbReference type="KEGG" id="cten:18247352"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_0_1"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="6">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="248" mass="26206" checksum="5095EDDEA6299F58" modified="2011-11-16" version="1">MKVAVIYYSTYTHVETLAKSIQSGVESAGGQADLFQIEETLPEEVLKAMYAPPKSDVPLASVDTLKEYDAFLFGIPTRFGNLPAQWKAFWDQTGGLWASGGLYGKPFGLFISTAGAGGGQEATARNALSSFIHHGMIYVPLGYGEAFPLLTNLEEAHGGSPWGSGAFAGGDGSRQPSKLELDIAAIQGKSFFTTANKLVGTSEPEPTKEAVTTATADSPTEKPVAKREAQSKPAEAESQSTCSKCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Z0</accession>
    <name>G3B3Z0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_134475</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Z0"/>
    <dbReference type="STRING" id="590646.G3B3Z0"/>
    <dbReference type="GeneID" id="18249795"/>
    <dbReference type="KEGG" id="cten:18249795"/>
    <dbReference type="eggNOG" id="ENOG502QVS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021988_1_0_1"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="85784" checksum="0B1DCDB86E49782B" modified="2011-11-16" version="1">MADFIDVGYLKSQRNILISQIDLYKELKIDINKNPSENGKVMVLIGDGYFTEKTVSEADEFLDRRIHSLSDIVDRFNMSIKHESNESEKLKSSFVRDDYDNAVREMKSEEKLNEEGLPFMDIVEEMDDNGNIIGVTVNNKKHKDYTIMSLDHDNYSNSASKNIEEESKTLQSTIPGLEDEEFVDIQEELDEYGNVIGVKLGKVDEFEPFEDKPDNDNDDGGQIKELLEDLEVYGTPNGQSNTPKTNNLDISHVLDKIDELDLSGEDKFRLKSIVLDKEKAIDEPKISQVESYREDEEDEEEPQNFEEKLPQDHIIINKKDLLELEVLADDFNEGYEEEEEEEGLDDDYDFEFEEDGYDENEDDDDLDDEYESSFFGHSKANDMLWGQINKLRESKVKEKIPAKSNIVLEKSGAKQVKKSVTFNEELDIFEIERIKKEDYEQPKPISRFKQLKERHNETSNKAKPNNAEGSVSDIVERPVGDIVERPVGDIVERSVSDIMERPVGDIVERPVSDIMERPVGDIVERSRDNMELPNYTVTDNSNELARDIKSRQPRVSRFKKDKESVKIENPKSTKELVHNLTSTNIQVTDIVEQPMNEIFETSADVSVQNESERELLRMIQEYSQENDEIEGPVITNLSDIQKLNEMHDRLDVDSYEIPHDHDHEHDHDSHSPERVSNDIPITEKDTNTTGDLIEVMENDQVDFEVRSEYFRFKDQLKAKSSSDREIEPLVKQSRFKQRLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B419</accession>
    <name>G3B419_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113792</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B419"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="75"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="609" mass="68151" checksum="4B4E779023C6B192" modified="2011-11-16" version="1">MWYQTSGLEVYKGCNRQNFWETLEIAMSEITPTTKSDAKAVQTTEIYVEEAPRFKWRVVDTHSPKEIYNWRLYLCIAVFGLCGSMRGLDEGNTASTTLPSFQAKFGLDDPSLSEHAYAALVSNIKSMVQLGSILGSMISSYSVDKLGRVKSLQLVCFFMIIATIIQMTSKNVGQLYAGRFLEGALAVGLTVAIGPSYMSEVTPKAIRGMAGCMFAGAVYLGIMLSYFAIYGCVLNLPDDSNLQWITPLCVKIIIPGLILIGSFFAIESPRWLIKVGRNEEGLKALARLRNLSESHPFVIGEITDITESVQQELEAKRNNNFFGLFAQLVRVKSLRYRFFGLGCMVQLLGQWSGANSITIYASELFEFSGIKGNDQLKMTAILGVVKFCSAYIGAFFIIDFLGRRKAMYMGITIQLLAVLYFALFLLIVPDAAHEDTVLTTAQYRASQGAMAALYMGGVGWTIGFNSLQYLIGSEIFPLSTRTFAQSLIMVLHFANQYGNSKAVAKMLLTLQPYGTFFFFVAINAISLIWAWFFIPEISGRSLESMEELFSLPWYVIGRRGAKLCPDHSEINKMDYSRGTLRYLDDEKPSEEFIENDDHRESEEKDRDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B447</accession>
    <name>G3B447_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_97824</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B447"/>
    <dbReference type="STRING" id="590646.G3B447"/>
    <dbReference type="GeneID" id="18250717"/>
    <dbReference type="KEGG" id="cten:18250717"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008037_2_0_1"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000127">
        <property type="entry name" value="Vesicular-fusion protein SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="14">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="282"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="564"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="767" mass="86096" checksum="38A08E46D820AC24" modified="2011-11-16" version="1">MEKFGFHKVSNKPGPGNPTINHNQPVKAFKRQFRVDNCPNNSIALGNTIGVNPADIPEDLNYVIVDNMVVYSITRELSVKPGTVGMAGNVRQWGRWSLNQPVTIADFSLNSFNDNFIYIKSAEIFIDYRSTKKQSSNPINHNELIAQFLINYNNQILQATQPIVMDFKGQFFSLYINSIQLMDMAGKPTDFTSSPDAKGILTGQAEVDFYPHENSIINLVKDGNAKSRVSNKPRSNPIINPDFKLDSLGIGGLDNEFQQIFRRAFASRIISPDLVNKLGLRHVKGLLLFGPPGTGKTLIARQIGKMLNVKEPKIVNGPEMLSKFVGASEENIRNLFKDAEQEYKQKGDSSGLHIIIFDELDSVFKQRGNNKSDGTGVGDNVVNQLLAKMDGVDQLNNILIIGMTNRLDLIDNALLRPGRFEIQIEISLPDEKGRHEILLIHTKKMKNNNLLDDDIDFQKLAKLTKNFTGAELEGLVNSATSFAINNYTKSDSLAKVDENISKMKLTWQHFELALNEVRPAFGVNEENLSEGIPYGVIRYNEAIERILDMGRSYINEVSHSENERLISVLFHGKNGVGKTAIATMLSLESKFPFIKVLNGELLVGMNELMKINTIDNLFRDIYKSPLSVLIIDKVESIINYVPIGPRFSNDILQMLMVYLTRKPPNGRRLLILATTSQHSILKSMNLVDCFTKSIEIKPVTDLVELQIIMNDLDFMSENERLEILNQLQRFDQPLSLGIKKLLQVLMNAKFANLDVNGVVENLLDAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4B4</accession>
    <name>G3B4B4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_105628</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4B4"/>
    <dbReference type="STRING" id="590646.G3B4B4"/>
    <dbReference type="GeneID" id="18245827"/>
    <dbReference type="KEGG" id="cten:18245827"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078569_0_0_1"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="45"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="268" mass="29560" checksum="76B91D1AB81912E8" modified="2011-11-16" version="1">MNTDRRRILGPQDARIPDLGISTNANNSMDIDPAGFAAEKRSSDIQKMFMKTNFISNANGSSYIEHGDTIVQVSVFGPRPIKSSFIEQASFSVECRFLPHLKQDDALDIDGDHHSNPNGRTGLSYTEHKISSFVESCLVPSILLDKYPKSTIDLHITVIEHNSESTSLTNLVNWITVASSLALVDSGVEVRDIVTAGHIISDGQHVILDPIEPVSKRTDCLVCFMNLKNEIVGIWVDGDLDNLDTAIEECNKMSRTIRGNINSYLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4K7</accession>
    <name>G3B4K7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114005</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4K7"/>
    <dbReference type="eggNOG" id="ENOG502RWDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_0_1_1"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="492" mass="52980" checksum="5F535EABCA7EE37F" modified="2011-11-16" version="1">MVSSTVRKSFVLLSCTFLGLICGTMYLYSSYSPQFAAQLGYSVTDSSKIALAGTIGVAIAGPISGKVVDRSGYSWAMIIGGVFIFSGYLGLKKQFDIIYSSLPVSNLLLFMVGMGSTFINSACLKCCAVSFPSIRGVATSLPLALYGLSALFYSVIGSVFFPGDTSRFLGFLAYSSMAIFCLCSPSVFMADGEHSSRGVVHRKTISASGIEMSILRSPVLGHSPGSPAVGLASPIALPKASGSGTLIDEVESGSIFASSKFWILFFLTGFLAAMGQMYIYSVGYIVKALVTAGITFDSTISEEARAHLEALIQKNQQLHVGLLSATNCIGRLVSGICGDIISQSFHKRRSWLLFVPAIGLTITQIMGYQIEDYTKLTWMSLLTGFFYGFTFCLMPIIIGDFFGMDNFSSNWGFVGLAPILPSFYFTKLFGNIFDSNSFIASDGSHICSSGSGCYKSIFRLDMVVTVLCVVVVGVLNFGFRWLSKSPREYKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4L2</accession>
    <name>G3B4L2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_130333</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4L2"/>
    <dbReference type="STRING" id="590646.G3B4L2"/>
    <dbReference type="GeneID" id="18249441"/>
    <dbReference type="KEGG" id="cten:18249441"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="15">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="14">
        <location>
            <begin position="302"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV63974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="805" mass="93834" checksum="47CB6C0C338CAC26" modified="2011-11-16" version="1">MTYFGLYMEEFYGFTKGKYKAASDSSLLWGPYRSGLYFGIRPRIPRSLLSGLMWFNMDDYNGVRKMRHFYEQNDPMKKANWIYYDPRYGGRQVIIDKESHIKLVIDFIKSEDGKSWGVKVKSKPQKGFEHVKTSFVWYSGMESEPLETDIFGQETTAAVINLDMDRSIDGRYNGPIKLAGASEDLGFFTLSIGEGPTSNQRPKSIFDYEEIDPRQNRHLSLRVPNDEIWRAKDIFNSLLQDSVQDLMDKYGEEPIPPHQSFVMRDMNKFQGNLHFVQQIFEGEAEFYILYDNAFTPEDQKITKDNFEFKSKKVLDIFHSKFKQHFELLPPFDKQEYQPFAKEIVSGLLGGISYFYGDHLVDRETKFDDESFEKYELEGKLEGPHELFTLVPSRPFFPRGFLWDEGFHLLPLLDYDSDLALEIIQSWFSLIDDDGWIAREQILGPESRSRVPEDFRTQSPEIVNPPTLMLVFTFLLRNLQNEQFGNINAPKVVEDYGEIPLFDSSDLGKLVLSHPELLTNYTKSIYPHLKAHYEMFRRTQKGYLEDFGRSPDLEVYRWRGRTLTHCLASGLDDYPRALPADIAELNVDLLSWIGVMTRSVKLIANILGEDDDVKHYQEIENNIIKSLDDIHWSEEEGVYCDKSVDEDEIDVFVCYKGYVSLFPFITKMMGHDSYDKLERLVDFISDPEQLWSDYGIRSVSKSDPTYRTGENYWRSPIWVNINYLVLDALKHYKEVGSGMPKPLQQKISSTYHDLRVNLVDNTFKEWKRTGFLWEQYDDETGVAKGAKNFLGWTSTVILMMSMPENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4L6</accession>
    <name>G3B4L6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114011</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4L6"/>
    <dbReference type="STRING" id="590646.G3B4L6"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013661_4_0_1"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58303" checksum="D57E7D10BEF1500C" modified="2011-11-16" version="1">MSDPTYKKLDSTIVERELGLELESHDSHTFLLGSKESPQGRHLGIYSVMVLYISRVVGSGIFATGSVIFESCGRSPLMFALAWAISYTVAICGLYIYLELGSLIPRSGGTKVFLELIFNKPRMLMTVIFSVYSVAFGFCISSPLVFGEYFLRTFDLAVTGLRTRALAIGFVTLTCMFHAVSTRHGVMMQNVLGVMKIGLLVVLLLTGIWVIGFPTSMTGVENTLTWERFHQAEKPVTIASFSNAIIVSSFTLAGWNMGHISSNEVKDPVRTYKIAGPLSMLLILLGYTAINVCYVSVLTPTEFAESGNLSGSVLFEKVYGVHFGKRFLTFSVAMCTASNIFVVIYSVSRMSQEVFREGVLPFSVFMASNKPFGTPLRSICLCLFLSVTILVLAPSGGVYGYIVSIEGYPVQLYTLFTALGLIILRRRYPETKAPIRASVIGAGLVVIIMAYVLVSPFCGGNPNPKGTESWISYPLVSITLIFLYVLYWLVMFKLMPWIGRYKLVSETLELDDGLTIKKWVQVPQSYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Q3</accession>
    <name>G3B4Q3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 14">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 14">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_113873</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573</strain>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="16">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 14">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 14"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Q3"/>
    <dbReference type="STRING" id="590646.G3B4Q3"/>
    <dbReference type="GeneID" id="18247156"/>
    <dbReference type="KEGG" id="cten:18247156"/>
    <dbReference type="eggNOG" id="KOG3111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_0_1_1"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000074">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13 16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="12 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV64260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="241" mass="26389" checksum="5F890C8CDAAF2F5E" modified="2011-11-16" version="1">MVKPIIAPSILSANFANLGCDCHKMYDAGADWLHIDVMDGNFVPNISLGLPVISSLRQEIPRSNEKSFFDCHMMVADPEKWVPEIAKAGGDQYTFHYEATKNPLELVKLIKENGMKAACAIKPGTPVDVLYPLAEHLDMALVMTVEPGFGGQKFMADMMPKVEDLRAKFPRLNIQVDGGLGKDTVPVAAKAGANVIVAGTAVFKAADPKEMIQLLRDEVTKSLKEKDLLDTRCLKRPIPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4R2</accession>
    <name>G3B4R2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">DNA topoisomerase 2</fullName>
            <ecNumber evidence="7 19">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTEDRAFT_104632</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10573</strain>
            <strain evidence="25">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18 19">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7 19"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B4R2"/>
    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001935_1_0_1"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000011">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
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    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
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    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
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        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
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    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
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        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
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        <property type="entry name" value="Topo_IIA_A/C_ab"/>
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    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
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    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
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    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
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    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
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        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
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        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
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    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15 18 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16 18 19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 18 19" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="22">
        <location>
            <begin position="488"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="23">
        <location>
            <begin position="741"/>
            <end position="1212"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1237"/>
            <end position="1302"/>
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        <location>
            <begin position="1323"/>
            <end position="1429"/>
        </location>
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    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1050"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="1238"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1256"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1286"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1328"/>
            <end position="1345"/>
        </location>
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        <location>
            <begin position="1354"/>
            <end position="1366"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1399"/>
            <end position="1429"/>
        </location>
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        <location>
            <position position="831"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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            <dbReference type="RuleBase" id="RU362094"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="EGV63850.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
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    <sequence length="1429" mass="163061" checksum="5CB69E0F1889AC9D" modified="2011-11-16" version="1">MPEEVSSQPKSQKKATTSKAKSKTPLSDSTNISSMLSKSTAGSSQSRASEQYQRLSQLEHILKRPDTYIGSVEKSPIEMWCFDAATEQMVFKEVTIVPGLYKIFDEILVNAADNKIRDPTMKNIKVKIDPENNIIEVMNDGKGIPVEIHSKENMYIPELIFGNLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFQLETADASNEKSYKQVWSGNMSKVNKPRITALKTKKEFTRVTFKPDLSKFGMDTLDDEILSVMRRRVYDLCGTVKDCNIYLNDKKLSIRNFKSYVEMYVKAIKERNPESSEDEEKKFQTIVHEVFNESWEIAFAVSDGTFNQVSFVNSIATTSGGTHVKFISDAIITKLVDSINKKEKGKKKLMIRPQEVRNNMFLFINCLIENPAFTSQTKEQLTTKSNQFHSKASDKLVISDNFITRILKTSIVDKIKSIANANEDKALQKADGSKKSRVKGQVKLVDANKAGTKEGHKCTLILTEGDSALSLAVAGLTVIGRDYYGCFPLRGKLLNVREASTDQVSKNVEINALKQIIGLQHKKKYTPENVSQLRYGHIMIMTDQDQDGSHIKGLIINFLESSFPGLLEIPGFLLEFITPIVKVTVSQRGSSKKVLSFYTMPEFENWRETEGTRCRWKQKYYKGLGTSTDVEAREYFAALDKHLKQFHAIQGEDPDLIDLAFSKKKADERKNWLQEFQPGTHLDPELKIIPISDFINKELILFSMADNVRSIPSVLDGFKPGQRKVLFGCFKRNLKSEIKVAQLAGYVSEHTGYHHGEQSLIQTIIGLAQNFIGSNNLNLLKPNGAFGTRAAGGKDFSAARYIFTEINEITRKIFNPLDNGLLTYVQEDEQTVEPEWYLPIIPMILVNGAEGIGTGWSTNIPCYNPEDIVANIRKLMNNEELEEMFPWYRGWEGDLEIISKEKFKVSGRIEQIDDQTLEITEIPVKTWTNNVKEFLLSGLGNDKVKPWIKDMEEQHGMNIRFVVKLSQEEMAKSHQVGLLDRFKLISSINLTNMVAFDPRGKIKKYESSLEILKDFYYVRLEFYQKRKDFMIDELKNQLDKLTEQARFIKLIIEKVISVSNKKRKELIEILQKHKFKRFNKQNKVVKTEDDSETLFVDEEDIEEEENNADISELNVGNTTVNEEEEENKPENIFQQYDYLLGMSLWSLTRERYEKLLRQRDDKEQELNDLLRLSAKDLWNSDLDDFLSAWRKYLELDHEARANMVPMKGTKRKARRVQNGPLKKKVKTETQSEYDYKQDPKTNPKVKVVVKKEEQSKSQTKLPDFFSPSNSSKVVKKEAPKVVSLFSDSDDDEIFGTKAVSTSQSPLSKASTTTKVYTKPPTFFSKAKSPAASSSTPKPKKKLTIQDELEDLVEVAPPPTKRRPKVAVFSDDEDSEDMEIEDDDDDEESEVSDESYDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4U0</accession>
    <name>G3B4U0_CANTC</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_130247</name>
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    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="590646.G3B4U0"/>
    <dbReference type="eggNOG" id="KOG1274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:DNA repair"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
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        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="6">
        <location>
            <begin position="405"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="7">
        <location>
            <begin position="721"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="829" mass="93193" checksum="C2548C16EFC3C286" modified="2011-11-16" version="1">MAFARDRINAFPEGNSLVEYNPHINKLLVVNSVGILKIFKIDNPELEPTSVDVLENLTSLSSSNDKLLVANTAGHLELVDLNTNESKGIVYRSELPLRDSVLINEGKRLVCGGDDDKLIIINLEEGNSSSSIKLPQQVVNISYCMNAEILAVSLSNGDVQIYSTINEEPNLLETLKSAVSSKIHSSMDEIDYSDDHKHELVATKCQWLRNGEFLLTPSSEGIRTYNRDWELEKEFKFGNDADSIIDFKVSSNGRSVAVLNKDFKVVVFDSVSGDVTNKFDLENSEDLFINLEWYKDQLFLGSNKGVVTQIKDFIDSASKGSLGDIDDDGGSNTDVLASNSDAEPNGINRNAFDDSIIDAEDESDEDFPYYNKDVGSVLDRHKKRHRGNDGKITISQSAVEGDLLPYSPGSTPFSRSANVERRYLTMNSIGYVWVVKTDETEGSQQSITVSFFDRSVNKDYHFNDYHKFDLCGINRHGVLLGHSNYQSSKSYGSLYYRSHESDQESWDKKIPLHTGEYLTSISITDNEDSIVVVGTSLGYLRFYNQQGLCVNIIKVNPIVSVIASSINSIFLVSRLSVNLYSFSIINCYDYKFIQQDAILPLKSDWKSPLIKGIFFNEYNDPCLVPGNDDTLMILSSWREPSNSKWIPILNCAQEVTDNNNASKKNWKCWPLGLFGDKLNCILSKNNDQYPGFPLAMPIELSIKMPINHIDTSQSEQQEDEDYEENYVKAKAMGIITNDSLTDQDYQEFNDEISDKLAYYSNLFDKSLLKLFADTCKQGNLPKSYSIAKLMKNDKALIAASKICQRFEFNNLAVKIGKLRDSLVDFDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4X0</accession>
    <name>G3B4X0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114036</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4X0"/>
    <dbReference type="STRING" id="590646.G3B4X0"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032690_2_1_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="198"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="345" mass="39048" checksum="E2DF286FBFEDEC09" modified="2011-11-16" version="1">MPQRQTSEYIEDLEEAFRIVKVDEETYVGAHPLRLPIGAARGVYGGNTIAQALLVGITSSPADFTPLAFHSYFIGPGKASTPMTFKVLKINDDGDIINRSIHAIQDGEIKFTALVTCIRKGAAVDDTFDFQKHPQPSHHQYRDPGALHTLRHTDYIRNAYTDEFVDPTLVPEEKALSPADRWINIWSGIHQHNNQFKDPRFGLVGIGGVSDSAFLTTLARVLHAPWNPTETKAFQEVDLDKDAKLLMNISLNMLHIFHYNAMSLDHHIYFHTQDSSDFDICNDWLTFNYQARRVSNNRTLVRGYFYNKSGKKLATVAQEGLTLAFKGFDTIPEETTNYKDFQVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B523</accession>
    <name>G3B523_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">CANTEDRAFT_98296</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686909.1">
        <property type="nucleotide sequence ID" value="XM_006686846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B523"/>
    <dbReference type="STRING" id="590646.G3B523"/>
    <dbReference type="GeneID" id="18250756"/>
    <dbReference type="KEGG" id="cten:18250756"/>
    <dbReference type="eggNOG" id="KOG3460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_5_1_1"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="88" mass="9987" checksum="86914630E1CAF096" modified="2011-11-16" version="1">MADVQPQQKQEEPLDLIRYQLDETVLVKLRGAREMKGKLQGYDSHCNMVLSDATEYIYAENQDKPQGKSTDMVFIRGDSVILISPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B544</accession>
    <name>G3B544_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS8m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_98307</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686929.1">
        <property type="nucleotide sequence ID" value="XM_006686866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B544"/>
    <dbReference type="STRING" id="590646.G3B544"/>
    <dbReference type="GeneID" id="18250758"/>
    <dbReference type="KEGG" id="cten:18250758"/>
    <dbReference type="eggNOG" id="ENOG502RXRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107213_0_0_1"/>
    <dbReference type="OrthoDB" id="4097133at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="156" mass="17335" checksum="99E1EDD1ABE42343" modified="2011-11-16" version="1">MSLVHLANFSAHIKNCTRLNISSTSVPFTRLHLQLSFLLYKEGFISSVQRGSNAGPDKTPAEVTPDNISSRRLWIGLKYRDNLSVIRNFSLVSKPNRKVHFTSTEIKALASGIPVGIVRPLQPAECMFIQTDESEILEVQEAAKKNLGGTVLCRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5C6</accession>
    <name>G3B5C6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_106968</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5C6"/>
    <dbReference type="STRING" id="590646.G3B5C6"/>
    <dbReference type="GeneID" id="18245926"/>
    <dbReference type="KEGG" id="cten:18245926"/>
    <dbReference type="eggNOG" id="KOG4137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071116_2_1_1"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="5">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="124" mass="14220" checksum="E414D46813E69E5A" modified="2011-11-16" version="1">MADLELSQLSYVTTKHHSFKSSTKVKPSNKRFKPARQLISDEIKYLQTKSLKFDTPTLTSITAPPTLKPSKKYCDITGLEGKYRSPSNNLRFYNVEIYQEVIRHMPPGLDQEYLSLRGANVILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5I0</accession>
    <name>G3B5I0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase I, subunit RPA14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114537</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687380.1">
        <property type="nucleotide sequence ID" value="XM_006687317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5I0"/>
    <dbReference type="STRING" id="590646.G3B5I0"/>
    <dbReference type="GeneID" id="18247466"/>
    <dbReference type="KEGG" id="cten:18247466"/>
    <dbReference type="eggNOG" id="ENOG502S8XT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109030_0_0_1"/>
    <dbReference type="OrthoDB" id="4093689at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013239">
        <property type="entry name" value="RNA_polI_Rpa14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08203">
        <property type="entry name" value="RNA_polI_A14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="211" mass="23845" checksum="5434D3B77116D3AB" modified="2011-11-16" version="1">MSSFRPRRVIPSAINTPTSVVIKSSKLATQSETERILTAFIDISESVATTVPGQASSSNEILNADSGLSNSTGNAAIISQLKRLQRDLRGLPPTLTEFNLVPELSSNKKIRFDDDSQDQPSNKKIKFELEEPQEVIIQTAMDETVDETINDTANETKDYPSSGEEEETKEETKEKKSKKDKKEKKERKEKKHKKDKTDKKEKKEKTHKHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5P7</accession>
    <name>G3B5P7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114571</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5P7"/>
    <dbReference type="STRING" id="590646.G3B5P7"/>
    <dbReference type="eggNOG" id="ENOG502SDGY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115926_1_1_1"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9828" checksum="8615265C65071C54" modified="2011-11-16" version="1">MDFMFFLFGFKEFNKPLKDVGSVACYCGNCHNQSAHAIRSINTVTLFFIPVLPFYFSKRLKCSICGASGDINDEIINRLRSGQPVAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6H6</accession>
    <name>G3B6H6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_123787</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6H6"/>
    <dbReference type="eggNOG" id="ENOG502SNTU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549942_0_0_1"/>
    <dbReference type="OrthoDB" id="4076777at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="534" mass="62560" checksum="9C68B73AEB31D6CA" modified="2011-11-16" version="1">MGLYATKVPHTSSMLSQYPIANLCGKRFFQSTAVIYKAKDANKQALRNLGMSLQNGIKNKQAKNEDIGIDDMDEEHKDNYKILQNYYDSISHMTTEDLLIQQNLDEGKQFRSFPSEHYLDRKNLIKNLPDEIDIFNTSLSKIEKIYKDLGKLDKDKSVQLKYYKRYLRNYSDPILRILQEFNGISDKFKMLRRNELDKLFLNPNSSLFNDNLFHLPYNVVGFDRSLSGFPLRTGKHRLTDICYPQEFIQDLQQCSPKVKLHKKDLDFVEYNENSISINPDDLIKPSNAKIDKAMNLIYNELDVPKKFILMDDLGQYKILRFNFLNKFNSIVETEINTLKASLQKEIELILSSDNQSTNMLLFNHQFFKNNSFKLCDFLKDTGRGSNGGATTSANMLIISYNVKELNLIPYNYLTDKSTRSRRRLFNHIFKLFLINLTDQIETLIRMKYSNRKQVFVNNLNAKISNIIRFKLLNLFDRVNQLKTIPIDQSVVLKPYYNRSFKRLYNYTKIPGSLHRRSATQFKLVDLEDKLKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6L8</accession>
    <name>G3B6L8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_114803</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687293.1">
        <property type="nucleotide sequence ID" value="XM_006687230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6L8"/>
    <dbReference type="STRING" id="590646.G3B6L8"/>
    <dbReference type="GeneID" id="18247588"/>
    <dbReference type="KEGG" id="cten:18247588"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="329" mass="37080" checksum="AD2CDE600BEE148B" modified="2011-11-16" version="1">MSTVLVTGATGHTGVFTVLEYIKNGYKVNTTMRDISQLSEVKEMIQKTGNLSDEAMKNIRYFQADLGKEEGWKEAIDGCEYVCHVAYPFINNVPLEQIYDAAITGTMNLLNLAANTESVKQFIFCSSFAAIGFADSYPEGTIVNDDSWTPEDAKILDGYMKSKILVEKMMWKFIKSSENKRGMSFTSIAPYMISGPLPWGYRKLVGVMGLIKLYITGGLDVILHYHLNNSDVRDLSKSFVSATNNKEAFNERFLLVEEKEHLMSEIVDILKRDFPAKYSEKVPTAVSPPLTISKITDSSKARRILNFNPIPFEESIKQSIENIIERENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6N1</accession>
    <name>G3B6N1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114293</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686769.1">
        <property type="nucleotide sequence ID" value="XM_006686706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6N1"/>
    <dbReference type="GeneID" id="18247356"/>
    <dbReference type="KEGG" id="cten:18247356"/>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026578_1_1_1"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="56"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="498" mass="54379" checksum="37FBE9E39922F847" modified="2011-11-16" version="1">MSSHLSSPMPRVRSPVASPASWNPLNDQSTLESRMTHDVSEIVDIIHDSEAKKFRLGVLLILVAVVSWVIGLELVNAVLKDGSYQKPLLFTYISGGCFALNLVPDIIRVFNRTPVPEPVEKDEDDPVPLTRVEFVVLSVQVAVIYFLYNACVLSCLKYTSASNQTVLASTTSIFTLLIGCFLRIDSFSVSKVVCTAVSFLGVLLVNFSESKGEASDGDNKFVPKNPKLGNTLAIAGALMYAFYLIIMKVKVGTGNRCTNERQLFGLVGVATLVLGAPVLYVADIYGYETFEFPPPNAITLLSIFINGVFSYISDFSTILASLLTSPLITSLSLTSCVPVTIFIDYMVLYFTGGSGSTTSTSRQVMYVTGILSILTSVVLINLTTTTENEFIENVIGESLEEGIKNDEILSPMLSPLLTARPHTLSNFSSPLLPMRRETTKKVSHLNLEGEGLINKNHNATLYTVDSRLEDDENERSNIVIYGGNNHIYHIKHVDSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6X5</accession>
    <name>G3B6X5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114350</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6X5"/>
    <dbReference type="STRING" id="590646.G3B6X5"/>
    <dbReference type="eggNOG" id="KOG0925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1849846_0_0_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="139" mass="15441" checksum="D6AE259F2CF8B624" modified="2011-11-16" version="1" fragment="single">MGKSDRSKRKLEAEAEAGKNIKSIKKQLATGDSSDSDVAANADQYSTGARPELASSFSHITRYNSTAKLAMDLEDASTNPFTGRKFTDQYFAILKTRRNLPVHQQRDEFLKVFQANQIMVFVGETGSGKTTQIPQFVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B749</accession>
    <name>G3B749_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114410</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B749"/>
    <dbReference type="STRING" id="590646.G3B749"/>
    <dbReference type="GeneID" id="18247415"/>
    <dbReference type="KEGG" id="cten:18247415"/>
    <dbReference type="eggNOG" id="KOG0658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_20_1"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF4">
        <property type="entry name" value="PROTEIN KINASE MCK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="378" mass="43177" checksum="148A270C42AF0768" modified="2011-11-16" version="1">MQPTISDEYILEVVENSTSASNKMIVKEYNKIGEGAFGTVVEAVLKYHYNQGNGTGDNVNAIHEDWIGPFAIKRVPAQTEYKSRELEILRAVNHPNIIALKYFFERKSSRDGVIYQNLVMECLPSNLQNEIKFYRQSKYTIPYPHMKAYTFQLARAMLYLHGFGISHRDIKPSNILVDPSKVQLKICDFGSAKKLEPNQPSVSYICSRYYRAPELIIGCQVYTTKIDIWGLGCVIAEMFLGKPVFQGKSPELQLKEISKLLGPPTNSFFFKSNPHYRGSMFQTKLFSGTVKERFEQIFSNSPPDAIDLLLKILVYEPDSRASPADVLNHPFFHELKRKSFHVYPRGSNNSISLNLFNFSNYELELLGPLKDELLNSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B813</accession>
    <name>G3B813_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">CANTEDRAFT_115793</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689028.1">
        <property type="nucleotide sequence ID" value="XM_006688965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B813"/>
    <dbReference type="STRING" id="590646.G3B813"/>
    <dbReference type="GeneID" id="18248019"/>
    <dbReference type="KEGG" id="cten:18248019"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="464" mass="51152" checksum="DCF3DC8357A5DA8C" modified="2011-11-16" version="1">MFRTPFPTTVKLGLLRLKNTTPQLQDVVIVGGGPAGLSVLAALKNSSKTAHLSCKLVEGGDLNKIRNFDETAYSNRIISLTNKSMRFMQKIGSWKHLNLDRMQFYDKVAAYDSSSHEALIEFTNDAINYDPMGAMCEVVNIQKSLIARIDELDQSDCLVDNVKVEAIEESTSEIDWPIVKLSNGDAYQTRLLIGADGYNSPVRRYAGIESRGWAYDSFGTVGVLKLASDQYNLVSLQRFLSSGPLAILPLPEDDATFVWSAKTEVASILKSITNDKIFVALINAALRLEETDLKYALNKLQVNPDDTSVIEDLQWRIELFEPNEQLDIPVVIGVQPGSRASFPLKMSHADSYVGPRVALIGDAAHTIHPLAGQGLNMGQADVASLVAAIETGIDRGLDIGSTLVLEPYFAQCFPYNHALLGVCDKLHKIFSNDVYPIILVRSFGMRFMNSLTPIKDFMIKTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8C9</accession>
    <name>G3B8C9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_136296</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688537.1">
        <property type="nucleotide sequence ID" value="XM_006688474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8C9"/>
    <dbReference type="GeneID" id="18249961"/>
    <dbReference type="KEGG" id="cten:18249961"/>
    <dbReference type="eggNOG" id="ENOG502S5B3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035821_1_0_1"/>
    <dbReference type="OrthoDB" id="2556122at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 ubiquitin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 C-terminal" evidence="3">
        <location>
            <begin position="115"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30611" checksum="8B46696BF9F2E4FB" modified="2011-11-16" version="1">MSATIVIRFIDSKKGEAIPDYEITDLQALSYQRLKHLIRSNNSYCTNKRLKLIYNGRVLNEHFDFKGDLISKFSESSLRIYVHCVIGEDLTKEQLRQESLLDNQEIKRTTQPEIIGFDRLLQQGFSQQDVDDLRAQFERIYNINQTNSQINDLEEEEQRQEYLRQLEERWINSTVNADGTSTRPAPEAAGTEQVTADAPANHTIATTDVDDTQNEDLLIGLLVGVFLGVIGVLFVVADDSVFDKRQRMAIIVGMFINISLAIIRGQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8I4</accession>
    <name>G3B8I4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_115194</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8I4"/>
    <dbReference type="STRING" id="590646.G3B8I4"/>
    <dbReference type="GeneID" id="18247764"/>
    <dbReference type="KEGG" id="cten:18247764"/>
    <dbReference type="eggNOG" id="KOG0470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011131_2_2_1"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="12">
        <location>
            <begin position="159"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="706" mass="81177" checksum="F26C03F25D600675" modified="2011-11-16" version="1">MSTVNHAESSPQALVKGALDLDPWLEPFQGEMIKRQLKFRDWYNKLSNTENSLSDFASSYLTYGLHADWDTKSVSITEYVPDVEKVALVGDFNNWDIHAHSLHKKNDFGLWQLTIAPVNGDFAVPHDSKYKIAMTLPSGEVIYRICPWAHRCTPSADPSLYDARFYNPPRELQYQFKHPRPELSEDGGVRIYEAHVGISTPEPKIGSYKNFTQNILPVIHRLGYNTIQLMAVMEHAYYASFGYQVTNFFAISSRFGTPDDLKQLIDEAHRLGIRVLLDVVHSHSSKNVEDGLNMFNGTDHYLFHGGSKGVHDQWDSRLFNYSNYETLRFLLSNLKYFLDEFRFDGFRFDGVTSMLYKHHGLGFGFSGDYNEYFNPQWVDDDAILYFMLAHQLLVDKGEKDNFRYLSIAEDVSGMPTLCLPIKQGGIGFDYRLSMAIPDMWIKILKHLQDEEWDLGNIVHTLTNRRHGENCIAYCESHDQALVGDKSLAFWLMDKEMYTNMSVMSENTPVIDRGIALHKMIRLITFSLGGEGYLNFEGNEFGHPEWLDFPRIGNGESYHYARRQFNLIEDDLLRYKFLFAFDCAMQRLDSNYHILNSSQAYVSLKHEGDKVVVFERNGLLFIFNFNPTQSFADYKIGVHTPGTYRIVLNSDSPDFGGHDRVGPVNAQGEPLKFFTNDDPWNDRANSLFIYVPSRTALVLQLEEKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8K5</accession>
    <name>G3B8K5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_131251</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8K5"/>
    <dbReference type="eggNOG" id="ENOG502QQGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010748_0_1_1"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000002">
        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="494" mass="55024" checksum="A2ECB69949495529" modified="2011-11-16" version="1">MSIKFEDSDTIHKIDDSRRKKVDIACVYCRRSHMICDNSRPCSRCIKRGIGHLCYDEPSNARQKKKASELSRSESSPGPPGASVSPPAYGIQQSLSSISQSPIQAQQQPISIQHSLSAGDTAGQPKNFNKSVLSQTMAFNLEPFFYSEHAGSEFSSLNDFLSMIDDPELVNGALNEDTPTSTNNDSTGLLNFGLVENTQPNPNPNPPNGSNSASTDNIQNILTYSPNSSAYQQFSGQYQQSPQQIAPVPVPPTPLEKRQPVSSQKSQTDAHQPVISDAARDKFFLTAADPTTEISPEERLKQVIKAKLEAGLLQPYNYAKGYGRLQNYMDNYMNSTSRQRILKPLSVFRPAFRAIARTLKDVDLVLVEESFERMLLDYDRVFTSMAIPACLWRRTGEIYRGNKEFASLVGVTTDDLKDGKLAIYELMSEESAVNFWEKYGAIAFDKGQKAVLTSCNLRTRDGIKRKSCCFSFTIRRDRYNIPSCIVGNFIPIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8M5</accession>
    <name>G3B8M5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115216</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8M5"/>
    <dbReference type="STRING" id="590646.G3B8M5"/>
    <dbReference type="GeneID" id="18247772"/>
    <dbReference type="KEGG" id="cten:18247772"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="674"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1055" mass="119706" checksum="10F93FE10B71CEA0" modified="2011-11-16" version="1">MSSLDKDVQHLSLNRTLSNTSSVVSTKHDYVDRPFSGKKEQFDQVLDILDNTGFIPEPLIESETKWFYESLGIDDVFFARESAEGIASHIHSLYACKVQAYSNDIADKPLIQYKREAEDHAVFFDTASVDGSDSRSSFEARIDDRYIDPSSSVSNSYRAEFFSARLNYQTDPILAGIYEKNHSIQNQLVRCHFIYKNNYDNQSVSPSETDISKIGDSTFLKIASKNTKRLYQEIIHGVLSTTGPVIRHYPIEDSEEYRVIIGFKQKSASRYNSALTDLTNYYHLQVTRKYVEQFANGVTVISMYITSKHQRSPVDLSIYQVIKEASLLYSIPYNYFHSDFIKGDLSIQESIYAHCGVIFVTHFLNRLGPEYNKLTSLLDPSKSTQHAEVLSSLKKRLRAETYTQNYIKEVFESRKEIIKKLYRQFADVHYIRSSMEKTLSYQRISQITPFANEEEFETILSRECSQNEHHVLVLRALYVFNKHILKTNFYTSTKVALSFRLDPSFLPQSEYPDTPFGMFFVVGNEFRGFHIRFRDIARGGIRIVRSRSDDAYNVNVRNLFDENYNLASTQQRKNKDIPEGGSKGVILLDPGSSQERPEANFQKYIDALIDLLLKQNIPGVKDNYIDLYNKPEILFLGPDEGTAGYVDWATLHAKSRGAPWWKSFLTGKSPTIGGIPHDVYGMTSLSVRAYVNKIYEQLKIESASIKKIQTGGPDGDLGSNEILLSRDEQYVGIVDGSGVIADPNGLDKQELLRLAKERKMIDSFDASKLSDLGYRVLVDDVDVKLPNGYLVTSGVSFRNTFHLKIKEVFGVNLVDLFVPCGGRPSAIDTNNVHDLIDGKTGKSVIPYIVEGANLFITQSAKIILEQAGCVIFKDASTNKGGVTSSSLEVLASLSFDDKGFSTHMCVDSKTHEIPQFYQEYVKQVQKIIVENAQNEFQVLWNLKKDTGLTFTELSDKLSVTINKLADELANSKELWNEDTEFRDAVLLDSLPPLLLKEIGIEKILERVPETYLKALFATHLASRFVYSRGIDSNPAKFLEFISSTRKEYKKKGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8P4</accession>
    <name>G3B8P4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_126298</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8P4"/>
    <dbReference type="STRING" id="590646.G3B8P4"/>
    <dbReference type="GeneID" id="18249163"/>
    <dbReference type="KEGG" id="cten:18249163"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_2_1_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000019">
        <property type="entry name" value="Kinesin-like protein KIN-5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="35"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="399"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="458" mass="51019" checksum="5E4E75B39FCEFFD2" modified="2011-11-16" version="1" fragment="single">MVSGLFSGSGAEPKLHRSSTPESRKHSEVEDGTNRIKVICRVRPLTADENAFQEMTSAGNNTVAVLGRESPQNFTFDKVFDVSASQSDIYDYSIKDTVNDVLNGYNGTILAYGQTGAGKSYTMLGPSISGDLEKGLIPRISDEIFHQIKTNGSNDIEYTVSLSIMEIYLEQINDFLVADNVKLSIHEDRDHGIYVKGLSHAFISNTEELYKLLQLGIKHRASHVTNMNMESSRSHAIFQIKIDQKNLKDESIKKSNLFLIDLAGSEKVDKTGAVGQTLKEAQNINSSLSALGNVINALTDHKSTHIPYRDSKLTRILQESLGGNSRTTLILNVSPSSVNELETISTLRFGSRAKHIKNRAYINKELSPAELKFRLSQLQRENEQNKLYIEKLENQLKNGGRAFTGPVTPSKDFESRIPTLTKSPKSPNLNAEKDQKIKQLEDEILSYKINNLKISNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B927</accession>
    <name>G3B927_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_136384</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B927"/>
    <dbReference type="STRING" id="590646.G3B927"/>
    <dbReference type="eggNOG" id="KOG0322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045414_0_0_1"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="438" mass="50258" checksum="6C5A3CEC4F57AE26" modified="2011-11-16" version="1">MHNELKSLILKVLASKNTGTLMNQLCSLRGHLNSITTIETRHNLIVSTDDHGWIIVWDFHTHKALYCWKGHDKTVLTTRILDDHHILTHSKDSEIRIWDLSPSQIGKLTSNLPDLTFNELTYLNDETSSLVAKFPLPKFDSIPVNSLNFCNIDYHEGLLITPSTIDSDNFDIYQVDPIDFNISRLIHNCSGFKHYKHHTGYIEEINGTKRDGFGIIMIAKFVNHERFFIGYESGHLLGFRLEFPSSQSNFTSTNTTQSRSIINKEPKISLVYYNEFHVPNPILSIEVLDSTQLLVGSTGKKITVHNIESTDILNDEVREINVKYKGIQSIQVINNLIVTGTWNGVIKIFDTKNDFMLVDKHEIKLPRLNTLTSNHHQNDQLIESSQKFSALRIQHYNSSINSNSKYKNIVLRKKSNKLLVLVGYNNGRLMVFEIDKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B951</accession>
    <name>G3B951_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_136403</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B951"/>
    <dbReference type="STRING" id="590646.G3B951"/>
    <dbReference type="GeneID" id="18249972"/>
    <dbReference type="KEGG" id="cten:18249972"/>
    <dbReference type="eggNOG" id="KOG0366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="3"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="324" mass="36518" checksum="867F0D96FA282F7B" modified="2011-11-16" version="1">MTLARLKHIQYVKNVDDATSRQSFEYWLSEHLRLNGMYWGVMALVGLKSLDTLPKPQVIEYVLSCYDAKSGGFGAYPQHDGHILSTLSGLQILLIYDSLHTIDDKRAQITKFIKDLQLPDGSFQGDSYGEVDTRFVYNAVSSLSILGQLTEDVVERASQFLVRCENFDGSYGMEPGAESHAAQVFTVVGALAIMDKLHLVKHDKLATWLSERQVKEGGFNGRPEKLPDSCYSWWVLSPLTILGHQNWVDLARLGDFILGCQDEEIGGFSDRKDNQTDIYHTCFAIMGLSLADHELYDLEAIDPVYCMPYSATQKIQKWPYAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9G4</accession>
    <name>G3B9G4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_131352</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688050.1">
        <property type="nucleotide sequence ID" value="XM_006687987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9G4"/>
    <dbReference type="GeneID" id="18249516"/>
    <dbReference type="KEGG" id="cten:18249516"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_0_2_1"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="27"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="204"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="458"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="854" mass="97846" checksum="E79330D9A150E62A" modified="2011-11-16" version="1">MDIFDTNSTNPINDPQLYRGVAKAAKVQVVIAVILGLSAFLTFALLRSKYPKIYVANFNQVNHNYLHSSSRQNLPRLPTKSLFGWIPIVLKINEEQVLEHAGLDAVVFLGFFKMCIKILSSCVILALVVISPIRYKFTGRLDQDYPPDNPDTKKRYQNNEYLLWLYVCFTYVVTGIVMYFLFKQTKKIINMRQKYLGQQNSITDRTIKLSGIPPKLRDEEDLKRHIESLGLGEIESITIVREWTDLNKLFKLRKKVLSDLENQWVYYFEINNLKNQNDLIAAHLHPNLGDSINLNRQYQDVLQDESASFSDTIPEPAEIPALARHSSIVQQLTDDFDNEVTEDSISHLPLLNDESFRRPRLRQKWWNVFSPTVDSITYYTEKLDIIDKEILKARTREYPATSSAFVTMKSVAEAQIIAQSVLDPKVNHLTSSLAPAPHDIRWDNLCMTRSERNSRIGTVTFFLGLLSIILVIPVSYLARFLNTKTISEISPKLGEFLKNNPYAETLVTGVLPPYIFTLLNMVVPYFYIYMTSKQGYTSHSDEEISSVSKNFFYTFVNLFLVFTLVGTASLTDTIKIAYQLAQSLRDLSLFYVDLIILQGIGIFPYKLLLLGNLLKFMFGSLLWCKTPRDYIKLYKPPVFNFGLQLPQPMLVFIIVIIYSIMSTKILTAGLAYFLIGYFVFKYQLLYACVHPPHSTGKVWPLIFHRVVMGVFILHVMMAATLSLQKAFYSVLALAPLPLFVLGCLWNFEKNYVPLSYFIALKAINNNELVAHSSYHDEESFLTDTNEVQTTVTNDANETFKTLDERREINQTYDYPYLIESLDGPLVAVDKNDLLLVNGDGMTVRKLKSSVGNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9J2</accession>
    <name>G3B9J2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_94778</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9J2"/>
    <dbReference type="GeneID" id="18250435"/>
    <dbReference type="KEGG" id="cten:18250435"/>
    <dbReference type="HOGENOM" id="CLU_762898_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="363" mass="40858" checksum="B02299296D01EE93" modified="2011-11-16" version="1">MKTNYLLDDLRSLGGYLERQNTIQQMKDASSTPISKLRPAVLLPDNPKFILSDFIGDFDEEVEFGRNLLPINADVWEFTGFSMPFEDETRDNITFDLDFGDQSKEESNTTIYLDPFDIDPSVIETSTPGPRTPISTPETVPAEGPKKRRFALIEDSEMVLGDEDYIEFIKNYEPLMKIGMLKFRRPKVSHFEQQFHGAEDLLFPTTPQTPEVARHVHDTTNAGISGLVSGYNTDNEFTYEDTDVFDLSFPEINISEVRSSSQGNIVVPSLEDISHSRELSNETRRFYNHLLNVDRDSLGVSPYEGKRISFSSVCPTRCPKSLVAKSLFSILELATNSVIGIECPSSLNLSATNIITVVIEQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9L5</accession>
    <name>G3B9L5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein ESF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">18S rRNA factor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pre-rRNA-processing protein esf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_94796</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9L5"/>
    <dbReference type="STRING" id="590646.G3B9L5"/>
    <dbReference type="GeneID" id="18250438"/>
    <dbReference type="KEGG" id="cten:18250438"/>
    <dbReference type="eggNOG" id="KOG3152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054086_0_0_1"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="105"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="302" mass="35479" checksum="B40999CBCF75CC61" modified="2011-11-16" version="1">MLDSEYESTAKKLSSKVHSDSEDDFNYSEDEYPIVKVQKKSYVNEQEQNEEEEPDDEENETGEGAQLTDDEVDEITQVKSKTRRKLKGLTPEQLEKEQKRIKKTGVCYLSSIPPYMKPSKLRSILSRFGKIDRLFLKPEDQKSYKRRVKYGGNKKRNYTEGWVEFLSKKDAKLCVDTMNGNIIGGKKTSYYYDDILNIKYLKNFKWMDLTQQISRENEIKQSKLALELSQQQKLNKTFVNNLDQSKMIKNIKRKKGTDQDDDVEIRRNFKQRNVTSTRADAKDDLKKNKPNEQLNDFLSKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9N3</accession>
    <name>G3B9N3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_115384</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9N3"/>
    <dbReference type="STRING" id="590646.G3B9N3"/>
    <dbReference type="GeneID" id="18247843"/>
    <dbReference type="KEGG" id="cten:18247843"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035825_2_1_1"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000017">
        <property type="entry name" value="Pyruvate dehydrogenase complex protein X component, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="11">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="410" mass="44225" checksum="9A49DAB6BD43A0E4" modified="2011-11-16" version="1">MLRTTASHSIRAAKSQFHTSARIAAASIFRMPAMSPTMTEGGITAWKVKPGESFAAGDVLIEIETDKATIDVEAQDDGILWEILANNGDSGIPVGKPIAYLAEPNDDLATLEKPPAEEEPTREAITPEASKPSPSKSEPAPAKSAPVPSSGSVITKANPNQKLFPSVELLLHKHHISPEDAFAKIEASGPNGRLLKGDVLAYLGEIQKDSVVSVANFIHEKQHLDLSNIVLKEPEASKPAEKAADKPAEPVKPKNILTLKVSAPLDVPNDQFRYAFENSIHSAITRTYAARFPEFATSPSGSSIISNADDIFDDLLAAPPTKSRFQVYDISYKFPTSNLNRLFAPIDAFDDLMSTPGKEVNSGSGSGSGVVDVEFKVKFDDKLTDSVEFVEYFQNSLLEQIPSKSLNVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9R2</accession>
    <name>G3B9R2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_125328</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9R2"/>
    <dbReference type="STRING" id="590646.G3B9R2"/>
    <dbReference type="GeneID" id="18249097"/>
    <dbReference type="KEGG" id="cten:18249097"/>
    <dbReference type="eggNOG" id="KOG1489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_6_1"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="4">
        <location>
            <begin position="120"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="360"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="531" mass="59901" checksum="9309FFF505E4817F" modified="2011-11-16" version="1">MLKSFSKTFGCGFHTRRPLRNNHSWLEEISVKQESPSLPTSSFIIKNEEDVVNEINDIPLQVIDLDENNRFLFRQLGEDDFGFGRTLVKLSDYFFGNTHQSMNAIMGEKSIKRAQKVERKAFQDLKVIRVSSGKGGNGAISFFRDANQPSGPPDGGDGGSGGNVYLKVVETMGSLHRIRRTYVAKGGQPGKGSQLDGKRGEDVLIEVPKGTTLRWIPDPLVLRESFKTTNKQSTWLEILTSYSGQYIQFFRNSFKPGEGWLFSEHDEEYFKERDFFVKLDETVQGYDQEIINEELTEDYFPILGMDLDDVTDKPILLLKGGRGGMGNMNFLTKDVRNPRFAKKGRDGNVQFFLLELKLIADLGLVGLPNAGKSSLLRSISRARPRVGHWEFTTLQPTIGTIYTTIDKDPFTVADIPGIIKGASENKGMGLDFLRHIERCKGLVFVVSLEKSPIEDLRILIEELGETKLKNKRKLIIATKADLNDNNKTYTKFKEYIETHLNIEGEVWNIVPVCAPQNQNIEKCIALMSQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9X7</accession>
    <name>G3B9X7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114815</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687521.1">
        <property type="nucleotide sequence ID" value="XM_006687458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9X7"/>
    <dbReference type="STRING" id="590646.G3B9X7"/>
    <dbReference type="GeneID" id="18247594"/>
    <dbReference type="KEGG" id="cten:18247594"/>
    <dbReference type="eggNOG" id="KOG1425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113408_0_0_1"/>
    <dbReference type="OrthoDB" id="4026656at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="30"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="199" mass="22552" checksum="5B8EDD7568C1FC3A" modified="2011-11-16" version="1">MSESVYVEDKAVMSDDNSDYSTTGTSSSGSESDEPVQLLQKPVFIKKSKSSDASASEAVAVANNTKHKVVTNLENANENIKSSQLGVEFNGVSDVDGLDPEKDYNEWKQREYVRYIRDRSEMIELEEIKADLIRRNQMSEEELVNIFEERQRAKPPNTTGASSRIGVFYNDDSLVQKLSERNYNEKHIDHSRPTKFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA36</accession>
    <name>G3BA36_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115466</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA36"/>
    <dbReference type="STRING" id="590646.G3BA36"/>
    <dbReference type="GeneID" id="18247882"/>
    <dbReference type="KEGG" id="cten:18247882"/>
    <dbReference type="eggNOG" id="ENOG502QWIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095040_0_0_1"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="184" mass="20489" checksum="AF159C0BDB290241" modified="2011-11-16" version="1">MTDYRSYQQVVDLAIRHPGKQKKSKVAKKTAAVPVSGKTRTKTGCLTCRRRKKKCDENIVNGKCQGCSRNFLDCSWPVLSQLKVRDEKDHIIALNGRKLSVSSDCSDCSTVSASTVATMSSTSPQLHAYSSPKYHSYPSPRSPTMDEMPIKLPPLRLPEPKQQQNPTPQFVVTCVDNCHSSFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA70</accession>
    <name>G3BA70_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114837</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687543.1">
        <property type="nucleotide sequence ID" value="XM_006687480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA70"/>
    <dbReference type="GeneID" id="18247605"/>
    <dbReference type="KEGG" id="cten:18247605"/>
    <dbReference type="eggNOG" id="ENOG502QWBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442600" description="2-dehydropantoate 2-reductase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="189"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="346" mass="39091" checksum="54BE55ECF928A5F5" modified="2011-11-16" version="1">MRPNVLVIGLGGIGTVAALSMELNDKADVSVIVRNQDEEFLQKGFLFDSVSFGKTSYKPRVAYKCVDEVGDVFFDYVVVCTKNLPDSKLPCERLIAPAIKPGTCIVLIQNGLDIEVPVLNKFPNNLVISGISLTGAWRYGNNVKHIAPDEVSFGIFKANSIPRHEAQPIFDRFVDAYKRDDAIITIDDNVELSRWYKLCYNAVFNTTCTVLNVDVTRCHIAVGNNSIFRKLCYEVVDIAKSAGYVLEPERVEYILHKSDGRFYRPSMQIDRDKNQLLELEVIMGNPLRIAERNGISAPNLMMIYNMLKIIQFDIREKQGEFKINPDDFRDVSGEDAPKVFKRIHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAI0</accession>
    <name>G3BAI0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115519</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAI0"/>
    <dbReference type="HOGENOM" id="CLU_2003619_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="124" mass="13901" checksum="DDD2C414E523A584" modified="2011-11-16" version="1">MSSLDSKQTTGYYIHDVDETISSIILIQFSAGTRTKYYLCRRALCSTKVRKVRHRKQILASDFRRPSDYRQVRHRSGPTGRYDGGDGGGRVPVSPQLSPSPAPCKNNCSVLVIMALKHSCRADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAN3</accession>
    <name>G3BAN3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_94346</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAN3"/>
    <dbReference type="STRING" id="590646.G3BAN3"/>
    <dbReference type="GeneID" id="18250385"/>
    <dbReference type="KEGG" id="cten:18250385"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 11 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="15">
        <location>
            <begin position="1002"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1167" mass="132408" checksum="97D64309C5E99C92" modified="2011-11-16" version="1">MKQQTLMAFFKPAKKPVINSSPVKKLDIDIQNENSDSDKENDSKFMEDVTTDTPLTSEMDITVSKSEKTPQSSPIKQKVERKQQPESDELQRSVAKKVNYLESEDEDDDIVPTKRRRVVESSEEEDDDEDDFKPHDSASDDDMSDFVVEEEDSEPEPEPEEGSDVEDIVEAPRKSSKPKIKAKVTTPQPKSAGKPSMSSDFAQKFKTGSTFVATTPPTTTVTTKSSLSSKKASSFAKENEERYQWLVNIRDAEKRSSEDPNYDPRSLYIPQAAWSKFTPFEKQYWEIKSKMWDTVVFFKKGKFYELYENDAVIANSKFDLKLAGGGRANMKLAGIPEMSFDYWAKEFISNGYKVARVDQKESLLAKEMRGGGSKEEKVIKRELTAVLTGGTLTDLNMITDDMATYCLSIKEEKVNDNDYKFGVVFVDTATSELNFIEIEDDKYCNKLETLITQVRPKEVICEKHNLSSLASKVLKYNNSNQIWNALDSLTEFWDYDLTLEKLVKSQYYPGEDLDDFSNFPELLVEFKDNHQLAFNAFGGLLFYLKTLKLDESIMTLKNFKKYDINKSSSSHLILDGITLNNLEILNNSHDGSDKGTLFKMINKAITPFGKRMLKTWVLNPLLNAEDINERFKSIEFLMGDGADFRQTLESGLTGLPDLERLLARIHGGSLRFKDFLKVIEGFERISKLVDNLREFTSREMGSLHKFVGEFPSDLHELIAEWEDSFDRIQALSDVISPTKGIDEEFDDSMDKINNLESQLNTYLQQYKRQYKSQEICFRDSGKEIFLIELPNKIKNIPKDWQTMGSTSKVKRYWSPEVKLLVRELLEQKELHKMVCDNLKSNMFKKFDTHYNTWCKAIGSLSKLDCLISLTRASELIGYPSCKPNFVNSSNGFIDFKELRNPVYQGTKEFIPNDVRLGGEEPKFCLLTGANAAGKSTIMRTTALAVILSQIGCFLPALEATLTPVDKIMTRLGANDNILQGKSTFFVELSETKKILNNATPKSLVILDELGRGGSSADGYAIAEAVLYQLCTHINTLGFFATHFGSLGLSFENHPQIKPMRMGIIAEQDSRNITFLYKLEHGAASGSFGMNVASMCGIANEIVENAEMAAKNYERTSNLKKMKEFNKLSLGLQSDYSWIMKDTDESPDDSLFKFDPEQVLVNIFKMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAN5</accession>
    <name>G3BAN5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Respiratory supercomplex factor 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_135405</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAN5"/>
    <dbReference type="STRING" id="590646.G3BAN5"/>
    <dbReference type="GeneID" id="18249874"/>
    <dbReference type="KEGG" id="cten:18249874"/>
    <dbReference type="eggNOG" id="KOG4431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087356_1_0_1"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="10">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="163" mass="19007" checksum="BED79A866E4A11DD" modified="2011-11-16" version="1">MSMRLPSSFDDAQKSEDEMDVIEKMKFKCKQQPLVPIGALATTGAIIMAVRSIRRGDRMKTQIYYRYRVGFQLFTLCALVGGGYFFQSDSVAQKKTREDKLREKAKLREQLWIEELERRDAAIQARKLRAQESKEELEKIAKEGFNEEKYRKGLEEKGKKTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAV1</accession>
    <name>G3BAV1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114924</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAV1"/>
    <dbReference type="STRING" id="590646.G3BAV1"/>
    <dbReference type="eggNOG" id="ENOG502SE4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2222938_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="106" mass="12343" checksum="72915D2AEE0E605F" modified="2011-11-16" version="1">MLRPGLFSRMVSSSIGAARFMSTTSFARPSSGMIFPGFKLFQTVKPSLISSQVNTNWDWDTPNPISEEDNTMYMDSVMRKRRLKMKKHKLRKRRRAQRALMKRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAX5</accession>
    <name>G3BAX5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114940</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAX5"/>
    <dbReference type="STRING" id="590646.G3BAX5"/>
    <dbReference type="eggNOG" id="KOG2763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="108"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="316"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="511" mass="57344" checksum="628561DF007C438F" modified="2011-11-16" version="1">MISTTILRTHGPTSRGVARLAHRASTYQMIRLKSNLHRPDAAGSNDPTEAADAAATVLADLGDLQKMPNKATWIEALREREAQLKEGKVLDSYSYKSVKTTEVGEKTREDSFSYLTLPFKDDKWLCDAYVNAQGRLRAGQLFQDLDALAGRIAYRHCSPAEPVNVTASVDRIYMVKKVDEIYNFNFILAGSVTWTGRSSMEITVRGYAFENGTPSEITIDSLPQDNIFLSANFTFVARNPLTHKSFAINRLLPVTESQWLDYRRAESRNNLKKLSAKNAKVIEPTAEENELVHEMWKASKDFEKKRDKPKNITLMKNSEMTSTLFMQPQYRNRHSYMIFGGYLLRQSFELAYCASAEFSSGGPRFVSLDSTTFKAPVPVGSILTMKATIVYTEHIHEGNVDIDADSPFNFKLPAKNKLTTNPEAFLSEPGTLIQVKVDTKIKSLDSSESKESGSFIYSFFVAKNGGGQNVPGYSSVIPRTYSEMMEYIEGRRRAGDTAHYVEILPSVKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBC6</accession>
    <name>G3BBC6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115622</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688975.1">
        <property type="nucleotide sequence ID" value="XM_006688912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBC6"/>
    <dbReference type="GeneID" id="18247938"/>
    <dbReference type="KEGG" id="cten:18247938"/>
    <dbReference type="eggNOG" id="ENOG502S2A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_6_2_1"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="49"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="537" mass="60539" checksum="955F5F4527303B47" modified="2011-11-16" version="1">MPTAYINGNVHTVDDKLPKAEAFIVSDDGTFSKVGATEEIKSIASGMTVIDLKGQFVMPGMHDAHCHLLMASKEKLFEAKLGVYSTPKEIVEQFKEYSHGACAHLNTVSNWLIGNFYHYAQFDDKKPDRKFLDEAFGDQPVVIREYTTHNIFANSAALRAAGYEENPVDPWDGYYVRREDGTITGELVEGAATRLFNSIPKGRLEDNVTALEYGVKMSNRFGFTAVQEASANTIYLEAAQQLEKQGKMTINLDAHVVFYGVGAFPQESVGSLHHTLWNAKDYKSKHFNPMFTKCWIDGVPWHPHETHTPLTEDGKVDYNRLLIPQETFKKYIERFDSEGRVCKVHVCGQGSARFALDCFEALRKKNPNGPKHELAHNMDVTEEDCKRYKDLNITAEMSPAIWHDPDFQPETNPKSVYPFNHLKKYGALLTIGSDWVFAPDTPNIFPGLQALTENKHGWDMTREEVIKMVTINGAEATSRDTTEGTIESGKLANFVILDRDLTTAETIADTVVYKTYFEGREVYDFATDELKHFQGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBL9</accession>
    <name>G3BBL9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF747-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_124417</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBL9"/>
    <dbReference type="eggNOG" id="KOG2490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003655_1_1_1"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="644" mass="72524" checksum="FA85F75F2980DF8B" modified="2011-11-16" version="1">MVGSPMSTATSVRPDHDIHTNSRPHQRAPRSRSRSGSTSRSASSAAASRQRSRSSATGSFINFLSNDPARNRPQPRNGDNRHFSLYRLLMLELNIPGNSKQKSGYAHSADVSDHEAYEQIIDMVKIPWVLEKFMGLGLMICTNSFLTLFTLVPIRIVVITFMAVQSTISEKSYTWQLISQKFRSVRRDVLTVVLILLSLSVLSLPPIDISKIYHDVRRQAQIKLYVTFGVLEVADKLCSSIGQNILGITFDLIESPPTRKNYFSTVLFFLGSVAYLCLHAYVLLYQTVSLNVAANSYSNALLTLLFSNQFSELRGSVFKKFDREGLFQLSMADLTERFQLSLMLGMITLRNILQLNSIGSGMIPSSWQTWNKWFGALFGPSIVVLGSEILVDWLKHCYISKFNRIKPRVYYNFIYVLALDYVEVFSSSSHKTSGEYELSDYTILTRRIGLPLLATTVCYLRMSLGNFVTLFTVETSSTVYSVLSSVLLMSVTFVILLLLRLMLGIALLKVTNAIKVNHENKLDEVHDSILETSDPTPSLLLRREGLLPEAEDLNTTPLSPLSPVSPQSPIPKTAADISFLPGLPNTEMSTINPATREFLYDNNENIPPTPEEKRNKDFIEKFETSYDEGLGEVQRYEMSSKRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBN1</accession>
    <name>G3BBN1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115041</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688740.1">
        <property type="nucleotide sequence ID" value="XM_006688677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBN1"/>
    <dbReference type="GeneID" id="18247688"/>
    <dbReference type="KEGG" id="cten:18247688"/>
    <dbReference type="eggNOG" id="KOG2765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026578_1_0_1"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16913">
        <property type="entry name" value="PUNUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42896" checksum="8547F6951B3BFC5D" modified="2011-11-16" version="1">MSLSETLSQWVRSSVFFQKESNLSSRQKWILGLVNLGSVVIFWVSSSFLVSDLFDSDVYRKPFMITYLNTACFTLYFIPYLKLEGLGVSEFVALVKAEYSNSPPAFNDIETVSYGSGSDVNEIPPEPTPDLKVGILETISLSLKFCALWFAANLATNCSLSYTSVASQTILSSTCSFFTLIIGFVYGVEKVTRSKIYGIVLCFVGVVIVTRDDSSATNPATSNWLVLMGNLMALIGALIYGIYTILLKMKTVVKNSTLERELNTHLFFAFVGIFTLVILFPVMVILHFTGVERFVLPTNKHALTSLSINMLITLISDFCWCRAVLLTSPLTVTVGLSLTIPLAMVGDWVLKGFQLNLFYISGAAIVTIGFLIINHDEEQEFSHNHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBP6</accession>
    <name>G3BBP6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_125844</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688374.1">
        <property type="nucleotide sequence ID" value="XM_006688311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBP6"/>
    <dbReference type="STRING" id="590646.G3BBP6"/>
    <dbReference type="GeneID" id="18249134"/>
    <dbReference type="KEGG" id="cten:18249134"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_0_1_1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="29"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="400" mass="44646" checksum="84F0C551EC7362B5" modified="2011-11-16" version="1">MSQFSHLELQPADEFNDLRIKLANDSDPNKIDVSIGVYRGEDGNSFTLPVVRRAKALYHEENYGHDYTFCLGLPDFVQNAAKVIIGETLVSKKLVASCQTIGGTGACHLGALFLSQSSGYKNFYLGVPAWPNYLPLIKQAGGTVTTYSYYDTEKKQVDFNAMLRSLNAAPAKSVFILQLCCHNPTAADLTIEQWSQVAEIMKKRDLIPFIDAAYQGFATGSMETDGLPIQKFIEVGCEVVVCQSFSKNLGLYGERLGCLHVVVNDVAHTPLVLDQLRYMYRAECSSSPAYGARLMALITKNDELLTQWKKDLQDMSSRLRTTRATVYELLTEKYKTPGTWEHVKTQRGLFWYSGLTEQQSKKLLDEHHVFLPKSGRVNVAGLSDRNVDSFCAAFDAVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBV6</accession>
    <name>G3BBV6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3 11">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_116112</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3 11"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBV6"/>
    <dbReference type="STRING" id="590646.G3BBV6"/>
    <dbReference type="GeneID" id="18248171"/>
    <dbReference type="KEGG" id="cten:18248171"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_2_1_1"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043647">
        <property type="term" value="P:inositol phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="366" mass="39361" checksum="CCC593B436F2116F" modified="2011-11-16" version="1">MSSIPSDHKYAHELKIATLAVKRASILTKSLGDSISVTRTSGSQIKDDKSPVTVGDYASQALINHALKLNFPQDEIVGEEDSDSLKDGSEEANRLSSKILEILEDVQQKTVNWKSDIGELKDLESVYTSIDLGNSEGGSKGRFWALDPIDGTKGFLRGDQFAVCLALIEDGQVVLGVIGCPNLAEKVVSNTNMTGTKGGLYSAVKGLGAYYTPLFDTNEFVPLAKQEPIKMTQETSPSKLVVLEGVEKGHSSHSTQSQIKAHLGFSEETVQSQTINLDSQAKYCVLAKGSADIYLRLPISDTYREKIWDHAAGNVLITESGGGVCDIEGKELNFGNGRYLHSKGVIAANKAVLGRVISSVKAVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCH1</accession>
    <name>G3BCH1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCH1"/>
    <dbReference type="GeneID" id="18248496"/>
    <dbReference type="KEGG" id="cten:18248496"/>
    <dbReference type="eggNOG" id="ENOG502RQES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2277147_0_0_1"/>
    <dbReference type="OrthoDB" id="4094421at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="102" mass="12077" checksum="7977888AA66B5D15" modified="2011-11-16" version="1">MSNTNNKESTAEQQQQMDELFNQLKGSIDKQKYPQFEEYIDSTHNYLANVMKQMEQTDDKDRTSKEIADDLSGKLNKWLESKQKELETQQKKQESKPQTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCS5</accession>
    <name>G3BCS5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_128572</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCS5"/>
    <dbReference type="STRING" id="590646.G3BCS5"/>
    <dbReference type="eggNOG" id="KOG2505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014293_1_1_1"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="13">
        <location>
            <begin position="193"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="548"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="597" mass="67100" checksum="512D004626FB2410" modified="2011-11-16" version="1">MSAKIQAENFLESYSIMSGKNIPKNSLYVFSLSQELVESLELVKFDVSEQHNLETAPKALKVQRLRDDDDDDLTKYNQKREAKGLSRLTEDEFDRLLEQGSVESISGSDTDSSSDSEDEDDALYKRLTETKISEAIIDETSNASHLNSKSSSIFFKSSMLSGDKHLGAFKALFSPKEMMDPITSLKTWSDLQDTGKSALFMMGGGHFAGAIISHRRKNIKGNAVNHKLSVEEQKVEIIKSKTFHRYTTRRKQGGSQSANDNAKGNAKSVGSSIRRYMEQALIQEIRDLLKSWESDLNQCKSIFIRANASQGKKTLVGYEGAVIKQGDVRIKSFPFTTKRATTSELKRAWTQLAYLSITDAVKEDKSLKERLLKQQENLIKSTQQKQHTKEQEITESDKQTVDLLGFAKRQKAPMLINFLKKHNLSPNLELTPTSQYVLTPTLLHFAAANGLTHIVQVLLVNLKADPTLKSTSGKVAAELSSNKQTRSIFQLARHKLGDDYCDWDAAKVGDAMTKEQIEKEEQEENEKIRLEKQRQIQEQLDLKTEMELKKPTFSSGGQLGGVSLLSSTSGLNEDQKSRVLREQRARAAEARMKKFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCT9</accession>
    <name>G3BCT9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_111473</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCT9"/>
    <dbReference type="GeneID" id="18246284"/>
    <dbReference type="KEGG" id="cten:18246284"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025794_0_0_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442640" evidence="3">
        <location>
            <begin position="20"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="93"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="622" mass="66632" checksum="261CE3253D250AC4" modified="2011-11-16" version="1">MVSALHAFGLAVWLAVVAARVDDDDDKKSSSSITIIITNSNLGSGFSLNTDSTTTSSTRTTTSSAVSEGSVVSEEDNDSSLLRFLFTETSSYYNIPVTINHQSLDLRLDVLQNDAWVLNGNEMMDCGEIDSWWSSYSTAFEDSSASTSIPASLTTAAEYTALYCGDAGLFTTSTNATVAEPDYGGYQPAEEVAVAYIDSINATGEVLTGNFSVASSNQQLVELKDFQFIDADTSNVYVGGFGLAHNNNTDTGIMAGLVDSGVISHSSYSLYFNNFANSNVSFAMVFPGAVNSKYYTGDLYQFNVLDIEGTRFDDDSALAAYGNRRVQSMVLPSFELTDILIESSGGESQSLQSKSTVLAAVFDSRTIYNSIPLSVIVNLAIQTNAFYNDEVARWIVQCDTIRETHATLNFQMHELLIQVPIDDILINAVIYEKQLTFSNGADACFLSVLPMTGSYATLGLSAMKSVFMAVDHEGGTIGLARANKGVQVKYSDYFPDDDNTLSPYEPDNGFNFSKESVESISEISPGTIPFATTASRENSMTLSYEAGGSQAESLTIPARLSGVLISSGEVVVTQNAQESTSDSSSATAASEDSHSKNGSGSNHHSLWQLIVLVVFPAVLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD23</accession>
    <name>G3BD23_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_137365</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD23"/>
    <dbReference type="STRING" id="590646.G3BD23"/>
    <dbReference type="HOGENOM" id="CLU_1346012_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="204" mass="21673" checksum="53A7EC79C6F98355" modified="2011-11-16" version="1" fragment="single">MVFGFGDNDNDKNDRSSSRDRSSSRDRSSSRDNNNSYGSSNSRDNDNSYGSKGNSDSYGSGNSGSYGSGNSDSYGSGNTDSYGSGNSDSYGSSRGGNDDSYGSKGTSTLTVSETVTLTVSETSTLMVSETATLMVLPNVTTTTRMVLLTVTTKTHTALLEAVMTTRTALLEVETLMAPTTETATDTNFNFKCIMYHVIAIKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDF0</accession>
    <name>G3BDF0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Na+/solute symporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_128749</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDF0"/>
    <dbReference type="STRING" id="590646.G3BDF0"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="72073" checksum="1ED5D35E2D8D0C24" modified="2011-11-16" version="1">MSTANDIFPLYSSGVGYGLVIGFSSAFALVMCLISFLLKKYFQEVQDSEMYLTAKRSIKSGLIASSVVSSWTLSATLLTSTTFTYSYGISASFWYSAGCCCQIFLFAVAATELKRKAPNAHTFLEVVKFRYGAWGHLVLCFYSLVYQFFISINLLVGAAQIFENVTGMSQEATCFLFPLGVGIYTYFGGLKATFLTEWLHTSILFIIMLISLFVLYATGKVAGSPGFIFDLLKKASAEVPVDGNAGGEYLTLRSVMGGMVGLIFLGGGFSATVDSQLFQKAIAAHPRSTFVGYVLGALCWFTIPFCLSITYGLGARALELTPAWPTYPNALSAADVNNSMVMPYLAYAIMGKGGVILILIALFQAVTSALSSETVAVTSLLTYDIYRGYVKPNADDRTLRRVSHLSVLLFLLVIASVAVGFCHAGFSVSFIVTAIGILIDGAVIPSACTLFWKKQSKYAVAIVPVLSSMISISTWIAVAYHRSNSVTISTLSDLYPIVAGNMIALTAPIILTPLITFLGPEDFDFEKLKGLQTVNVNQSDDSTVSTEAEKGVDQEEVDSKATGEEVEESVSGPDQDHHKREVLRLLAIALFFVLSICILWPIPMYGTSYIFSKDFFTGWIVVTFIFAFLASGTIIVYPIFESRLEILLFFKAIGRGVGSSVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDG3</accession>
    <name>G3BDG3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_99764</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDG3"/>
    <dbReference type="STRING" id="590646.G3BDG3"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF44">
        <property type="entry name" value="MEDIUM-CHAIN FATTY ACID ETHYL ESTER SYNTHASE_ESTERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="147"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="423" mass="47255" checksum="28BE9F8E793F1EF5" modified="2011-11-16" version="1">MFSSFLPAWGFRATKTINKTDNPTQLTQKNGEKTDLNDIVIELPSLSTTSKLILHPLLFNGVLQTMYYGSSGGQEGFKVWYGRELFSYKNGGISSLDWVIEEEAPELFKGKYNETLPENWPRLFPRTRFFTAEELENLKNNSSETKPLVVILHGLAGGSHEPLVRNFAELLTSGKNKDKFDVVVSLSRGCGRTKVTSGHLFNALSSTDDIHEVLLEMKNRYPNRPIYAVGFSFGALTLLNYLGTYANESSKLLKAAAIVGCPFDLGESTRFIESSWSGAYLFNKSILAFLNKLVKNNLNELNKYEPELFNKENLAITMAAKETRVFDEVFTSKSAGLNTADEYYKTSSSLTWIPQVKVPLLSISSSDDPTIGKFIPTELLKQNPNIVSVVTDLGGHLAFVTPSKQFWSVRVIDEFLEAMETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDK4</accession>
    <name>G3BDK4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_116375</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDK4"/>
    <dbReference type="STRING" id="590646.G3BDK4"/>
    <dbReference type="GeneID" id="18248271"/>
    <dbReference type="KEGG" id="cten:18248271"/>
    <dbReference type="eggNOG" id="ENOG502S8HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013298_1_2_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59397" checksum="3B27DB2330ADA1AE" modified="2011-11-16" version="1">MNFKPIIGQNIDTDPRHSFWTDVFNIIEGGSINITQGDISTAVQYVDKSQQQEGPNSKSVLLSKAYISPETTRELTMKHNFVMSTLPRKLHKSTYVKGANGIVIIGGQKFSWLSYLSLVALRKSGSNIPVEIVMPQHEDFVQEQEFCQKTLPKLNARCVVLAESLGAEVMFKWSSNFANYQLKSLALMVSSFQNVLLLDSDNILVQNPDSLFTSKLFKDYGMVTWPDYWERTISPVFYDISGLKVNEDKRVRYNRFPLATPDGLTSNLNTRESIADEVPYHDLEGAIPNLSTESGQVLINKDTHACTLLLSMYYNMLGPNLYYKLFSLGEQGEGDKDTFPAAASVCGENFYQVKSFIRTFGYFDDGGNFQGVAMGQKDPLGDYEKYQKYLETPSKSKENKHIPIKSQIENIDNLQKEHFSGDSGKLFAIHCNFPKFDPVGLLAREDLWDAENKRLKYRLFSGFTYDDPNIKAKTLDFELEQWKNIEKALCSETIDFPYFKSENIEEICTLARNQVRFLQSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDP1</accession>
    <name>G3BDP1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_111583</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689562.1">
        <property type="nucleotide sequence ID" value="XM_006689499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDP1"/>
    <dbReference type="STRING" id="590646.G3BDP1"/>
    <dbReference type="GeneID" id="18246297"/>
    <dbReference type="KEGG" id="cten:18246297"/>
    <dbReference type="eggNOG" id="ENOG502QQ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007860_1_1_1"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="50"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="645" mass="73675" checksum="8E69A48371207C3F" modified="2011-11-16" version="1">MSIGNQLYLIVHAIVYDLVVVFCQSIIHTFFKDIRVRGSFNIPKKGPIIFVIAPHHNQFLDGSVVAAKIKEYGDRRVSFLVAGKSYRDPFIGLLSRLTSAIPVERAQDLMKTAKGKIYLGDQDNIIIGEGTKFTKDCQVKGLIGLPNSKGNFQIVKIVSDTEVEIKGDYKDKRESLTKIRYDMLRAGSRYKTAPHVDNHVLFQKVFDFLNSGKAMGLFPEGGSHDRSDLLPLKPGVAIMALGAISQCKDPDGVINIIPMGLNYFHAHRFRSRAVIEFGKPLQITKEDGEKYLKDQRKTINDLLNTITFKLKEVTVTCDDFETLVTLQAVRRLFTTGQREQIPLPMVVEMNRRLIRGYELHKDEPDVIEMKKLVMEYNKQLMLLGLHDHQVDSLTASNKLHTAIVFLGRLFKVFLFFGLSMPGIFLFSPVFITAIRISKKKQKEALAGSVVKIEAKDVLGTWKVLVALVLAPSLYVFYSICGTVLILKLDVIPWLNSSWKYKALVFLFCYFWSVLTTYASLRIGEIGVDYYKSLKPLFYSLVSENKDLIQIDELKNQRQFLSQKVTDFCDRYGRVIFKDYQEFYDLYNENDIDVNIANVKIFSDQVSEHSSSGDEEEKETHRNEEIRNEATRNKISKMMKKKSKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDW6</accession>
    <name>G3BDW6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein kinase RAD53</fullName>
            <ecNumber evidence="7">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_127596</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="7"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDW6"/>
    <dbReference type="STRING" id="590646.G3BDW6"/>
    <dbReference type="GeneID" id="18249250"/>
    <dbReference type="KEGG" id="cten:18249250"/>
    <dbReference type="eggNOG" id="KOG0615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379543_0_0_1"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009202">
        <property type="term" value="P:deoxyribonucleoside triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000651">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016256">
        <property type="entry name" value="Ser/Thr_kinase_Rad53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000661">
        <property type="entry name" value="Ser/Thr_PK_RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="50"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="155"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="578"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="759" mass="85483" checksum="EEA8DBCC0097B0C7" modified="2011-11-16" version="1">MEPTQATQPTQQSPSTQAPSTDPNHLCRLICTTGQYTFFDFNISGGKKSWSFGRNQENDFILNNSTRYSNKHFKFWFNIDGKTLWVQDTSTNGTYLNNNRLVKGSNYMLNQGDEVSVGNGVRKDELKFVVLFSDLFNPSNHNSTIKDEGIYKDFIVHNETIGQGAFATVKKVIERATGDAYAVKIINKRKALNTGGGMVEVERELSILRKLNHPNIVKLKSFYEDLDNYYLVMEFVPGGDLMDFVAANGAIGEEATRVITKQILKGIHYVHSKGISHRDLKPDNILIMSDDPIVVKISDFGLAKISDNSTFMKTFCGTLAYVAPEIITGKYGASQPTQTQTQSQSPNTLYDNSVDIWSLGCLVYVLLTSHLPFNGKTQNQMFSKIKSGQYHTSPLNMYKVSELGLDFIKNCLIVKPEDRFTTEQALNHEWIKSIDDGMGDDLEFPANGGSQSQRLSLSQSQSQQLRKIDNGISITSNNQIDDQDQDMMMRPLKKEEFKVPKRVVPLPQSQPVKRDNDDFTKVNGFIKQSTTQAVSGQPMEGPQKKFTNLPLDTFIMLEPTKDSMLDKPIVIRQGINPYAIGRNETCDTYINDDRMSKIHCLLNRRRHPVMELSIYESPAHCLEDIWLLDFSTNSCFLNGGKIGKGNKIQIFDGDRLDLFVDQYTHEGLSYTIHIIDKTGLFNEGKRVNQSLVIKQDANDQKLRPMPVDSVLNSVIGNGGNFNSALRSQKKRQGLENSNSVVKRADLKVENFPAGRSWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE09</accession>
    <name>G3BE09_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GIDA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_132193</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE09"/>
    <dbReference type="STRING" id="590646.G3BE09"/>
    <dbReference type="GeneID" id="18249600"/>
    <dbReference type="KEGG" id="cten:18249600"/>
    <dbReference type="eggNOG" id="KOG2311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_1"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="7">
        <location>
            <begin position="586"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="675" mass="74471" checksum="1528CA32745E1409" modified="2011-11-16" version="1">MLSKVGVMRRISLSADLQRQLEKAPFHPVIVVGGGHAGCEAATGSARTGTPTTLVTPHINKIGTASCNPSMGGVGKGTLLREIDALDGVASRITDKAGIHFKILNASKGPAVHGPRAQIDRKIYLEEMQKEILNYKGLNVLEAQVEDIIIGPVKDKSVDTEGRLFGNVEGVVLGDGQVLRCDKVVITTGTFLGGEIHIGLKAYPSGRIGEAATFGLSKTLKDAGFRLGRLKTGTPPRLSSKSIDYTNLEVQPSDYPPQPMSFLSDRVDLQENLVDCHITSTTPEMHKLIASNLDKSIHIRETVKGPRYCPSIESKIIKFPQKSSHMVWLEPEGLDTDLVYPNGISCTMPEEIQEQMVRMIPGCENVTMVQPGYGVEYDYVDPRELDVTLKTKLVEGLFLAGQINGTTGYEEAASQGCLAGINAGLAHLGKDPLKILRSDGYIGVLVDDLITKGVEEPYRMFTSRSEFRISIRADNADKRLTEKGYNAGVVSEERYLKFKSEIKQFEQIKEHMQNLKLSGARWSPVLKGLISDVKRTAYVDGWKLLSYKGIGLEDFLPHLESFVDGTVPQFYQQINSRLLQRINIESSYDPWMKKEEAHLKAYEADENLLLPLNYNYTNEGNLKISYEVCHLLNTIQPETIGQARRIQGVTPAAIFELFQLVKGKQSILASQRGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE49</accession>
    <name>G3BE49_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116508</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE49"/>
    <dbReference type="STRING" id="590646.G3BE49"/>
    <dbReference type="GeneID" id="18248337"/>
    <dbReference type="KEGG" id="cten:18248337"/>
    <dbReference type="eggNOG" id="KOG1803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_9_1_1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="250" mass="28903" checksum="502C01F8BE762726" modified="2011-11-16" version="1">MQLPPTIKTLDSAVKIDKKTTANLEVTLFDRLVKYVEGNKYKKLLDIQYRMNEEIMQFPSQELYEGKLQAFKDNASISLVDLPNVERDDDTELKCIWMDTQGGDFQEQMNEDENNSKFNEYEAALVNQHLKKLTSLQVAPQDIGVISPYNAQVSLLKRIINNPAVEISTVDGFQGREKEVIIISLVRSNSSNEIGFLKERRRMNVAMTRPKRQLYVVGDLELLSGSTEYLKHWCQTVEAHYDIRYPEIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE65</accession>
    <name>G3BE65_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_109929</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE65"/>
    <dbReference type="STRING" id="590646.G3BE65"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047845_4_0_1"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17663">
        <property type="entry name" value="PFA-DSP_Oca6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000084">
        <property type="entry name" value="Tyrosine phospatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF14">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="190" mass="21438" checksum="FA14957837EA9656" modified="2011-11-16" version="1">MFIPPLKFSTVQEGFYRGAYPREINFPFLESLSLKTIVSLTPSPVTPETDPKLYDFATRNKITLVHLECEQSGKGKKRGVPLGYSTVLEALDLIIHTSHSPIYVHCVNGGQVTSLIVACLRKLQFWTSLTIFNEFINYTTNITLNDRNFVEGFRGDIQVDSSDKVSWLWNGMSNGVVSNHPMIKIHQSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE89</accession>
    <name>G3BE89_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116545</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE89"/>
    <dbReference type="STRING" id="590646.G3BE89"/>
    <dbReference type="eggNOG" id="KOG3504">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_169255_2_0_1"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60490.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="63" mass="7123" checksum="CDE0B2E89089F43C" modified="2011-11-16" version="1">MSKSKNHTAHNQSKKAHRNGIKKPKTNRYPSLKGVDAKFRRNHRYALHGTAKTLAKARAEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEA1</accession>
    <name>G3BEA1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_132241</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EGV60498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BEA1"/>
    <dbReference type="eggNOG" id="KOG0386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_15_1_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:histone binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140008">
        <property type="term" value="F:histone H4 reader activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
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        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
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        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Bromodomain_CS"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="HSA_dom"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
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        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_C"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
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        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="14">
        <location>
            <begin position="440"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="608"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="919"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="1325"/>
            <end position="1395"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1195"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1436"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1210"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1226"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1244"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1268"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1453"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1480"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1503"/>
            <end position="1515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1515" mass="174180" checksum="61369A0068FD9126" modified="2011-11-16" version="1">MNRQISREEIQKILHRLAQLKAQHGDRAINDPEYVELAKIIRHIQSQAQLQRQQQQQQQQQQQQMPVSQNQLSMPATGNPHNNFSQPANSNAPMMNSAEPPVNNQNMGAMNPMQSQIPPQQQQPPPIPPQSQAQATFNNNSEIGENNSQAVGGSAFTSQQFQVVKGEYQALRLLLKNPGPNSVPIPQSLADFVTNERLAFAHGNYLPSNYNGSANTAVSTSQAPTQVPTPGALQPQSQNINATMGAQQIPPQITQSKPPSRPPGFIPVSHEPHPPVLLGEFIDDSAKKEMKIIPVVQPNVQVDCFEVPHLVGDEIQDVQFQHLYSNQTRFQHPSLYPEGIDMKEIKKNREALIILQIEQRLEFLKNELKSESDEVRKDNIEFAITQLELLPYQKQVKGTLLSHIWFSKSLLPNSHPNFLAKYKPLSLTNVIESHQLYKKQVYSLLQAQNKKHQNEMSEIFRIINTRKNVTQLKRDKAERFINRINSFHSSVAREEQKKLERMAKQRLQALKSNDEEAYLKLLDHTKDTRLHQLLSQTDSFLDTLAQAVVTQQKEAGGEILGMSEEERREKLDYYEVAHRVKEEVKRQPTILVGGTLKEYQVKGLEWMISLYNNHLNGILADEMGLGKTIQTISLITYLVETKRVPGPFLVIVPLSTLTNWNIEFDKWAPTIKKITYKGTPIQRKSLQYEVKTGNFQILLTTFEYIIKDRNLLSKIKWIHMIIDEGHRMKNANSKLSETLTHHYHSDHRLILTGTPLQNNLPELWALLNFVLPKIFNSVKSFDEWFNTPFANTGGQDKIELNEEETLLIIRRLHKVLRPFLLRRLKKDVEKDLPNKVEKVVKCKMSSIQSKLYQQMLKHNILYTSDENGEPVIIKNANNQIMQLRKICNHPFVYEEVENMLNPRSETNDDIWRVAGKFELLDRILPKFKATGHRVLIFFQMTQIMDIMEDFLRLRNLQYMRLDGGTKADDRTQLLKRFNAPNSEYFCFLLSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITEDSVEEMILERAHAKLEIDGKVIQAGKFDNKSTAEEQEALLRALIEKEEERKLNSEDSDENLDDDELNQVIARNVGELDVFKRLDDQRISTTREALYPSRLLSEQELPALFQRDPESVLKKDEIRPDEYGRGNRERKVANYDDHLTEEQWLKQIDGVASESDGEDSRPKRSKSRPKAKPRRTTQDLDDFVVDYDSDNDDSLKRANSNDSSAVDSKKQRSATPLSARSRARPPRIRNRAKGGRSRPATLIRQTPTLDPLAEKEREVLQNQADLIYEVVLNYKDDSGRNLSELFLVKPSRKLYPDYYVLIKNPLAFDTVKKRITSRTYTSIRELLEDLHLIFSNARKFNEEGSIVYEDANLLESVAFEKYKELSDESEEQVSKILNFDDFEEQYGLRKEEAEPASEQSSEPEPEPQPQQQPPSPSRLEVEVDDSIGKHIEEDDLGLPDIPGLDDDDDLMSSHLNDLDLPHDIDFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEI5</accession>
    <name>G3BEI5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_111208</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEI5"/>
    <dbReference type="eggNOG" id="ENOG502QYHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007231_0_0_1"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1144"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1270" mass="141478" checksum="61687073291B1326" modified="2011-11-16" version="1">MSTTDKLARKVDDPDLYDSGVTNGDVDWLFRGKSKKLTKKMNLNKDIEKDTKDPKDSKDSKAPATPVPPEPSRATDSPKQPVESLPPTAPSSQDSPQDPSQDPAISPTDASGSRLNKLFRPRSGSLTKGDKKEKPKEKPKEKKFNLMSYSVLGAGIPVSPLATMPAAPRVRSRSSSVGSNSSAASKDKKSLFSSLSSKFKSVPPSSPTSVGPHEQVPASDGSPKLNTNFFGKDDISQFHAKPPAELSGIPIKRKNSVQEQVASSADKLSSSANSFNSFFKRRTSTSSATSQSSTCPPGSSRLVLNKNPHKEKSPLKELEGVSLKRVNFAIDKLLFDPQQQIPSRRPKKGNVLIPEDLTAPPPRLLQGTSLNDCSSTKAGENKFSDKELTLAVEAQRRALIEAEKHAQEAHISAKRIAFEVSQYKIKPRLSQITTEETVGGASELDEEPVSSEGQDFGDARNIEIDKPLHLHEKHFEEDTYHSDVSNLTLEQIYTRCCHLREILPIPATLKQLKNKSKPLSVLKLLNPKPTLIDILSFSDFIAIVPITTVIFDNVTMTTEMLKHLLASLAYNKSVEKLSLRNVPIDKTGWKYLCSFLSRNHSVKKLDISQQRIKSDLKPSLIRSSMNWDLFTKSLVTRGGTEELVINGCKLTDEVFKELVEKAVYLSTFRLGIASCELNGFKTNLVCEWLKSPDCKCVGVDVAFNDLSQGQLKYFTDCFNHSNVKLIFFSLYQTNLSNIEETAELLKALTKIKTLRFLDLSSLPDLFPGIISKLNAYLPKFENLKRIHFDLNDLTSQSMIAISEILPKVNGLLHISLLGNRNLNNSVAASIYNAIKKSNSIFALDLDYDLISDQLNQRMAFYLMRNMDHSINVDPSTGQRTSKDYQRPKDQEEEELMFDGSLLMETAERLLSENENSSNKVEDIRLNNIISNALIERTRELRQGIHKTIDTLFDKRNTGTLSLEGKESLLRFCLLDASLEKLVHLFEEQASKSGAEGMSPSPSVDEDLASPTTKLSKSTSLLSKKDGLPTIDLGDKELMHQSSTELITSGPILSPRNTETLNKLGYFQSNNESLTFQPHQVVVESDSEGQTFPIDYLTGRPVLMRSISQTSTHAKEQELEEGEFHRWGFFMQQRNNSSTDLQNQTKEEPKKPQRDHKSLPTLNVLPSGGELRDAIIRAKGIESITELIDKINDDRVSLEKIYSVADKSQQVEIERQLESLRLEEEKHKSQADVEDDAESIDSMGSGHEVNAVVDEVYDKLLNDAERVRSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEK8</accession>
    <name>G3BEK8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_111128</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEK8"/>
    <dbReference type="STRING" id="590646.G3BEK8"/>
    <dbReference type="GeneID" id="18246250"/>
    <dbReference type="KEGG" id="cten:18246250"/>
    <dbReference type="eggNOG" id="KOG3767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039425_0_0_1"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="328" mass="35457" checksum="24C7B6F37A2AE8D2" modified="2011-11-16" version="1">MASSVTGPVPLPDSRYDLSSYWGRVKHCAEISDPTMLLNTSSDIKRAKLMIWEYRNGVRPEMTPELWRAKKVLDSAVHPDTGDTVMLPFRMSSCVLSNLVVTAGMLTPNLGTAGTLFWQIANQSLNVAINTANANKSHPMTTKQIITNYGLAVSASCSVALGLNSLVPKLKSLQPNTRMIMGRLVPFAAVVSAGIVNVFLMRSEEIKKGISVFDNEGKEVGTSKTAALYAVGETAASRVINATPVMVIPPLVLASLQKTRFLKGKSKAVEILTNIGLIFSTSLVALPFALAVFPQRRTMAVSKLEPEFHNLKSANGVPVETLQFNRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEP7</accession>
    <name>G3BEP7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115973</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEP7"/>
    <dbReference type="STRING" id="590646.G3BEP7"/>
    <dbReference type="GeneID" id="18248104"/>
    <dbReference type="KEGG" id="cten:18248104"/>
    <dbReference type="eggNOG" id="KOG3284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076417_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="169"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV59943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="266" mass="30150" checksum="DE5DD37F583EBDA7" modified="2011-11-16" version="1">MSQPPSYAPTSTTSYTVPTTNYHKEVTRASLISSPLHKDVYNSLAEIYSILSVLELIENSYIKDYITDKEKYTSTSLRLINQYQIIVNGFKEDQAKIDICNALMTNLNGNFDEFLECFSQMFNPACPLAIKRLTSGVPVTIRGQDQDIGSQMSTRTNSTPVNGQSGSNQNARLIAEATSNFITCMDALKLNYKHKDQLHPLLSELVINLNELTEDNNNLDFHGKSKLITWLIKLNNLQDKELPSEEIEEFLNDLNIAYKNFYSKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEV2</accession>
    <name>G3BEV2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116677</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEV2"/>
    <dbReference type="STRING" id="590646.G3BEV2"/>
    <dbReference type="GeneID" id="18248399"/>
    <dbReference type="KEGG" id="cten:18248399"/>
    <dbReference type="eggNOG" id="KOG3343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086803_0_0_1"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="191" mass="21457" checksum="C6344B845B54C3CA" modified="2011-11-16" version="1">MTNISLYTITSCLILDKDGKRLYGKYYQTQTLHPELTTLAQQVEFEKKIFDKINRVNQDILLFNSNLVVYKQVNDVLLIIVANLDENESLIYQLLSNLNDSLNILLDNTLDKVTILEKYDMVSLCVDEAIDDGVILEIDSSVLVSRVTNPPSGASLGQDLNLNKIDISEKGFLNALSFASKKIGERLQQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF28</accession>
    <name>G3BF28_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_137094</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF28"/>
    <dbReference type="STRING" id="590646.G3BF28"/>
    <dbReference type="GeneID" id="18250038"/>
    <dbReference type="KEGG" id="cten:18250038"/>
    <dbReference type="eggNOG" id="ENOG502QPMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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        <property type="term" value="C:early endosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:recycling endosome"/>
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        <property type="term" value="C:trans-Golgi network"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:endosome organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:receptor recycling"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd11886">
        <property type="entry name" value="SH3_BOI"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Polarized growth protein (Boi2)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Boi1/2_SH3"/>
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        <property type="entry name" value="Boi1/Boi2-like"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="PH_domain"/>
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        <property type="entry name" value="SAM"/>
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    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SESQUIPEDALIAN"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
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        <property type="entry name" value="SAM_DOMAIN"/>
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        <property type="entry name" value="SH3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="249"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="618"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="809"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="885"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="400"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="436"/>
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        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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        </location>
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            <begin position="931"/>
            <end position="943"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="985" mass="109129" checksum="B3B6705B414BDC94" modified="2011-11-16" version="1">MKESDIDGSSRGGATASVYLCIKQFNSRLGDELNLKVGDKIQVLSDDSEYNDGWYMGKNLSTGKVGLYPKSFTQVLVEDTPDDYNLLRSRSRSRSKRLSSPTTPISAKPDSPVSKLKSNFESLSIKRPANGNYKTPGTTATATTHAKSSSSLFNPKTSKIFDEAHDLNDNNDTFNTTNGHSHLDDIDDEDNIDAEDREFGVNKTMNDIDKALEELQSDSYIHSTNTGHKRAPSNMSLTEDLNPKDAMSWTPKQVTSYFALGLGFDTSVAGKFARHKITGAILFELDLAHLKELDIDSFGTRFEIYKEIENLKKIVDGHKELDTDKNKTSEPQLLDSAKITRGPSEYGHQRKKSQSYEELRDTNKIVSPKMDKAYKFGEATNKEMYGSNNNVSTSVLNPPTESAGIKNRLSRPASSIYEQSVHSRNHSRNISGTSDYYGNHRRNSSVILSNNNHKRNSSMFSFMSKDKDEVDNKKYKEVKEKVSEKQGRKQEKLISPAKIKKERLPEVSTPTHDIHNNSEEIDIDSTQFSPRKSKSINHKYDEPRKLDFKDEKRSVSDSTATLNSSASSTPGTSTISRFKTLRTASTTNFKNLTSSKKSKTSAFQEGIRSITPDEAIKSANYSGFMAKRTGNNLSWRSRYFTLHGTRLSYFTSLKDKKEKGLIDITAHKVIPIDTDGEDKYIALYAASTGFGRYCFKLIPPAPGFKKGLTFTQPKTHFFAVETQDEMRGWIKALMTATIDIDDSVPVVSSCSTPTVSLAKAQELLARAREETKLKDEERAMQGNNGFLGDLNDFGDDEFSESQLTSFIGNYTLDPNTSGENSPLVESLEEGSESTSSPSEHPNLSIDTSGKPSVKGPTTPQLSNPTGFASPYLLASGLLSPKSNNGNVNFSPTMNHEDASSTSNSFSNTYNNSKASNTTTPIDQKREYFTDLDSNGSTPKSPASNGRVKSAISQSSGHKKKRHSEKLLAYSNDGSGNHTFVIKQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFC2</accession>
    <name>G3BFC2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein SEC66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116042</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFC2"/>
    <dbReference type="STRING" id="590646.G3BFC2"/>
    <dbReference type="KEGG" id="cten:90981892"/>
    <dbReference type="eggNOG" id="KOG4699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066294_1_0_1"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="26308" checksum="FB05734E48BCC9A9" modified="2011-11-16" version="1">MDEENPQSQINISVFTPIIYLCILLSCFIAFSVIYRRRRVNNLAKVVPIFEENHSANVYAFLNSQYSDPELPKDQKPHEKVMKAALLRRGVEAIRRSLRLKEAEPVYKTLYQDGLIGDDVFQQFNIQLKLQELEINEIVQQCESFKKNWAQSFFKVAQEICFNEALRRRLYSMSERKVDLSEVWEYYADKSETEVAKKIDSIEPPSGASGVEVSSSKAKKNKNKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW46</accession>
    <name>G3AW46_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_117327</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683708.1">
        <property type="nucleotide sequence ID" value="XM_006683645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW46"/>
    <dbReference type="GeneID" id="18248561"/>
    <dbReference type="KEGG" id="cten:18248561"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="483" mass="54084" checksum="F1058043DB7E6699" modified="2011-11-16" version="1">MGKYDDAHEFIHKFDSSEKQDEINIASVYRKIDMRILPLLSGIYFLQFLDKALINYAGVMGIKDHLDNPAQFSDLATILYAGYIICEPFVAFGFQKLPFAKFFGVSIVLWGVVVTLHSACLNYSSLMAIRFLLGCVEATAASGVLVCNGMWYSHKQQLSRFGIITSQVGSATVVGGLLSFGFQHVVNGSLESWQILFLVMGLITVVFGVMVLVILPDNPMNCKFLTDQEKLALLDHLKDNQTGIENKTFKWAHVKSYLKDKQSWLIHILTIISMIPTGAINTFSVTIIGTFGFDSKKSALMQMPVGVSSILAILIPMYSLYYLKGNYRTAMFVGLLLIAIAGYFILIYCTNTYANLFAVYFGNAGTCVITLIYSWNNRNTAGYTKRLIRNCGTMICIAIGGLIGPQLFKTDAPRYLPAKIALLVISFVSIPLVVLLGFVSRWENQKRDNISEKDSSDFHDHYGDDFEYKDLTDVENIHFRYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWA1</accession>
    <name>G3AWA1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_91656</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683753.1">
        <property type="nucleotide sequence ID" value="XM_006683690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWA1"/>
    <dbReference type="GeneID" id="18250098"/>
    <dbReference type="KEGG" id="cten:18250098"/>
    <dbReference type="HOGENOM" id="CLU_1434269_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442679" evidence="1">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="189" mass="21578" checksum="87CF64D3A69E88A8" modified="2011-11-16" version="1">MLFLPFMCTLGVISGIVLPRVETYSDSSSVSYPLDYGLNIIKGNEDINISIIKRDYSQDEADLFKKLFFKNQIHAFTFSGEGDIQDEACYDDRLPVNIIIHKGDKTTEAEKDFVDKLRKVKNVMEMPSTDYGIVDEDSLFKFDTDTTTEEEAIQIQTLQKKMIKNSVYAFLDRLNNLVYVVNGTTLNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWC8</accession>
    <name>G3AWC8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_112230</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683769.1">
        <property type="nucleotide sequence ID" value="XM_006683706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWC8"/>
    <dbReference type="STRING" id="590646.G3AWC8"/>
    <dbReference type="GeneID" id="18246413"/>
    <dbReference type="KEGG" id="cten:18246413"/>
    <dbReference type="eggNOG" id="ENOG502QRZ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031639_0_0_1"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06817">
        <property type="entry name" value="PLPDE_III_DSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="303"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="422" mass="46131" checksum="245DE457A5122C2A" modified="2011-11-16" version="1">MLFPADFTPLADKAKLLEAFKGKKLADLPTPSFIVDKSRFKTNSEKMLTNAHKLNADFRAHVKTHKTVEGTRLQLGSSELTTDKIVVSTLLEAWSLMPLVEEGLIKDILFSLPVVKSRLTELSQLADKIPSLRVMLDNADQLDVLADFNKQNPGTKKWSVFVKINMGTNRAGLINDSEFLATTLKKLAEAHVKEAVEVYGFYCHAGHSYASDSESTAKSFLLEEIKHANKAAKAAMSIDPSLHLQISVGATPTAHASEILTVEELEAAVGEKLSGNLELHAGNYPFCDLQQVATGCVTHDNVSCKVLAEVVSTYETRGDKGPGEQLINAGVIALAREFGPLPGHGRVVEPKGYENWIVGRLSQEHGILVPLDSDVETKFIPHGTKISVYPQHSCITAAAYPWYYVTDGGDVVEDIWVPARGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWG3</accession>
    <name>G3AWG3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_128933</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWG3"/>
    <dbReference type="STRING" id="590646.G3AWG3"/>
    <dbReference type="GeneID" id="18249351"/>
    <dbReference type="KEGG" id="cten:18249351"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038704_1_1_1"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="320" mass="35256" checksum="5D0CEF52445C95FB" modified="2011-11-16" version="1">MSFTFGFSEEDLNGESVGVVTAPTTSSAPPAPATDAVSPKVADISNLLLSLIGTSLSFETACTPNNNIVYKRALYDIKHQVMTEDNEELASLLLADDSDLKKNYYEGGFKVWECSFDMIDELHTNYADANTVVELGSGTSLPSCYVLFHRLTATSTAPLKLILSDFNYEVLRLVTVPNLLINWYVARKQPTASEFRITAEVVAEFETDLAASHVELVLISGSWGERFLQLVQHTAIDLVVTCETIYSLESLPVLSTMVIELVKRTRGAKALVGAKNYYFGVGGSVAEFVRYVKTHSDLEVTVREVSSQLKRSVVEVTQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX60</accession>
    <name>G3AX60_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VHS-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_117883</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX60"/>
    <dbReference type="STRING" id="590646.G3AX60"/>
    <dbReference type="GeneID" id="18248607"/>
    <dbReference type="KEGG" id="cten:18248607"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017092_0_0_1"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="9">
        <location>
            <begin position="186"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="8">
        <location>
            <begin position="452"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="63148" checksum="E5BECC86774215A0" modified="2011-11-16" version="1">MSSSSGYSLSKINPKLLRRIYRACRPSLDEPNLALNLEICDYVNAKQGSIPRDAAITVVKLISQKDPQTSELALSLLDNLVKNCGYPFHLQVSRKEFLNELVKRFPERPPLRYTRVQRLILAQIEEWYQTICKTSKYKEDFGYIKNMHTLLSHKGYIFPEVKVEDAAVLNPADTLKSFEELQKEEEVVNSAKLQELIRRGRPQDLSEANKLMKIMAGFKESNKVEENKQQILQDIARLKRKAEILDEMLTAIQQNGGKIEESNEAAHELYGSVKSNQPIINKIIEEEHDNEQRVGELLSLNDNINTLINKFQLLKGGKVDEASKMKANLNQDLNLIDFDDDEPISNDQTGKDTQGYNDLLSDLTSLSFGGEPSKKTNDDILNLFGSGGSIALGSNTPQPTEPSSKDFDLLAGFSSPSPQLQSNVQTTPVQSNNVLDAFELSFPSSTPSNITSTISKKTIHQSKAIQIDVELYSTGTTVNGKFFFRNVGIPTSTIAVFKFLVAAPKSCKLELKPQSGETLSGGSSFISQEFTIQNDLNKPLKIKWKADYTYQFSQTTQTETGVSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX61</accession>
    <name>G3AX61_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit CNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CNO-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_100841</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683954.1">
        <property type="nucleotide sequence ID" value="XM_006683891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX61"/>
    <dbReference type="GeneID" id="18245414"/>
    <dbReference type="KEGG" id="cten:18245414"/>
    <dbReference type="eggNOG" id="ENOG502S5Q7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141728_1_0_1"/>
    <dbReference type="OrthoDB" id="5424991at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034455">
        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="108" mass="12758" checksum="847E513F77E6708A" modified="2011-11-16" version="1">MVADSEEEDPMGLKQLALSYDYLIYKINDHVKSLSDITFESVSQKESLIKRDYLQQQLKLDMEMAQIDKLLVECDKLELEFMKLDQLKGFVDDFKVRVSRLETQFSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXK7</accession>
    <name>G3AXK7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_100406</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXK7"/>
    <dbReference type="STRING" id="590646.G3AXK7"/>
    <dbReference type="GeneID" id="18245377"/>
    <dbReference type="KEGG" id="cten:18245377"/>
    <dbReference type="eggNOG" id="KOG1816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037790_1_0_1"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="356" mass="39265" checksum="EF508A7D0A4D84E5" modified="2011-11-16" version="1">MFSGFGSTMFGGAAFAPMNNKFEDYFRCYPIAMMPDSIRKDDANYGGKIFLPSSALNKLSMLHIRYPMLFELLNETTQKKTHSGILEFVAEEGRAYLPQWMMSTLELQPGQLVQISNCDLPLGRFVKIEPQSVDFLEISDPKAVLENVLRRFSTLTVDDIIEINYNDTIYGIKVLETKPESSGQGICVVETDLETDFAPPVGYVEPEYKPKSQAPTSKPITPTSVNRGAGSATMARSLNYANLATSSSTNSFGGSGQKLSGKAVESTKPKDISVDDLDPEAPPAPFPIAENKLFFGFPVVLPTPSPTDEEAESTNKQKAFHGSGQSLRQSKKRKDKNNNHTPLKNHSRSPDYIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXT2</accession>
    <name>G3AXT2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_92011</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXT2"/>
    <dbReference type="STRING" id="590646.G3AXT2"/>
    <dbReference type="GeneID" id="18250144"/>
    <dbReference type="KEGG" id="cten:18250144"/>
    <dbReference type="eggNOG" id="KOG2140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006308_3_4_1"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="272"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="477"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="541" mass="61424" checksum="C1FD2C4501034E00" modified="2011-11-16" version="1">MSQTSTEWIRLRTSIEALVDNLNEHNIDTIAVELFKLNLFKGKGLLVRKLMLSQRTSRKPAWVYASLVNVLNFKVPDIGKLIVIRLLIVFKNEYLHNMYVNIDLVCELVNYHVVNNLVILQILELLMSNITDDSIGVVIRILKHSGAVLPTNIVYAIIDKLRNLVNEKQVSNTSKSSIEKLLQIWRRGFKDFTAILIDGEMCHEIDLEDELDASIKLLKDDGKEYHEYETLKREILGELEEGALEEEHRPEEPQQHVSAEPVVDMSQAELIGLQKTVYLTIMSSLSSEESVHKLLKLNYKPEILAEIVIKSCVQEKTYSKYYGTICEILSVKFTKYKHEFTRLFEVNYENIHQIELNGIRNLGKLYGYLVATGKLPVTILKVISLTEANTNSSNRIFIKFLLKEMVEEVGTPTVKDKLTGNMQQLSGMFQMDGKRDDLVFAINYFTAIGLGMLTDEMRDELESRKRGRKRERHEVGSRSGSGSYSRSGSGSYSRSGSSSYSRSGSSRSASYSRSPSRTPSRATSPHHRATDERDSQGTSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXZ8</accession>
    <name>G3AXZ8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_92059</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684308.1">
        <property type="nucleotide sequence ID" value="XM_006684245.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AXZ8"/>
    <dbReference type="GeneID" id="18250150"/>
    <dbReference type="KEGG" id="cten:18250150"/>
    <dbReference type="eggNOG" id="ENOG502QRR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_225471_0_0_1"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="2990"/>
            <end position="3103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3117"/>
            <end position="3169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="3117"/>
            <end position="3128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3150"/>
            <end position="3169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="3169" mass="355339" checksum="E43648F9D8D5078D" modified="2011-11-16" version="1">MGQDKDKPSNNDIRGQLSDIQNRLFFSGSKDSKKPPKKKAAPSNVDASAGSPNSSPMKPNTTIIPNTVPSLGPESKGNDMNYVVGLSQNLVQECRRLNADNQKLKSKLKSNYEEVETYKQQIITLQTRGEAHASSEVDLKDRNWELESIVLGLKEQIAKLTSGRERLLKSAKGHEDQSSNYQKLHEDLQVKFNTYYEQAEKVKLNHSKDLALLNDRIQQLNDENDHLTVQLQSKAAGSTQSKSIAVNSDLLIPPSIKDDNSDNESIDFDSLMIDVNPHELPETDHGNPALEIETLRASLNHSNRTISKLRSTLLKYRADANKSLESISPNKSSKLSKKLKTMSELASPSNRSPAVLSPSKRSSKFMIFGNEESSSDFPTEEGKWEDFIGEDLDGVEAKRLSMLNSTTIMDSELDLPRHEPKEVNFAVATGDHTMPILVNSDSDDSDVEERGDSRSILSKDLLGADVQPKKQIEDYARDNNLILIPFDKYEELLSNDITSINDDRLKDFTKERGFVPLTTQEYDDLLSEKEMRKRLELMGIVTLPSAEINELNSTKKAYHEPSVQYITSNAEKMGLSTLKHKELESLHSKIEELSSPSESYLIEKCKERNMVLISQEAFDGYQTLVIDHEKPSKDYIKSKANELGLIISSSSFYDQLVKLANSPSAEHLQSKASEIGSIVLDKDTHEKLVNPDSNSVSKRATELGMIAVPIAEYETMKSLAHEPSLEHIRSLGHAHGQILLSLEEHKSLVDAVENPSIDSMTIKASSLGFSTIKTKDLQDLQKSANTPTLSQVKAHAENHDLVTLQRKEYTNMYKVANDPTLEDLSIKAAIKGHTLVESQELTRLKQLEQDPSLDFIQEKAHLVGYSVIEKQVLDSLNDLVDNPPLDVIKQKAEFNDHVLLSTNDHRSLKEIATNPGIDHITKVAALRDHIVLSSSENEKLQKAIESPSLEYLSSKATLLGFSTLEIEKLNELYKQIEHPTEDYIKDKANGFESLLVKKDVYNDLSRKVNKPTPEELITHAEALGYSAIPTNNLNSLQHLAHSPEVDHIKRTAERHHMVPVRVDEYQKLKQLAHDPPKDHIHKVAEAAGLVALAGTAHEALKLRAENPSVEKVKEIAPKYDLVTLNTEDHNSLLQTANSPTLEHIIEKSKDYGYHVVSNEEFEDISTKANNPDLNHIKSKATGLGHVIISDSEYRETVKSAREPSIEEINVHASRNKHVLIPFEEHQTLQKNANRPDESHLSKIAGAIGLVTLREAELKNLKQRAESPDLAHLKEKAVNHGHALVDNDELETLQLLADNPPLDHIRQVASTLNMNLIDKDEHESLTKLANNPSLSYIKAKAESLGFVVTEQDHYNDLLKLTQDPPLTHLSEKAAKINHVFIPKEQHESMLNPTKKDVETFAARHGGEFIDKAVLKSLKDFIESPTQEYIEEKAKTRGIVTLSDEQHKTLLSEANDFNKEKVIEKAALLSMIALPIYKYEQMKDIIENPSKEYLQSKVGAYHSTLIDSEELSSIKQSLESPTLEYLQNKSKTYDYVTIPEKEHDEMKNHLISPPKDFLAMHASALGMSLIGVASLKQLTDSTQNPTGDQIRKHAEKNGDVVISRDELKDLKEKLDKPDLSYLKLHAKSFDNTVVSTSEYQELLSLISAPTREHLEKKAESAGLVVVSKVEYNDLKNIVSNPDVNFIKAASKDLDLVVVESPVYNRMVQSIEQPDLEYLQEKSKAVGYETIECIKLEELNNKTENPSREYLESKALKLDLALISSKELRSLKENFESPSSGFLEEKAAIKGLVVVDKSSYDYSLSKLNKPDIDHIKEKATAHQAVVISESEYEQLLQPSKADVQKHAKGYGLITVEKIHYDSLNKQIEEPSLSFLTEKSAIMGYKVITNDSYKELNQLANSPTRDDIVRLGAGLGLGVMATDALSKLHHNAETPSIDHLTEKAKTHGSVVIDFKDYEYLKREANKSIDEKARETGMSIIGVDELISLRKRADSPSVDELRKHAQNNKLVLIEESEYRDLRAQAEETIEEAATKANIKLLAMDEFKELQEKAENPSHERLAAKAAALGFSILGAAELKSLRDHKSTSLDDHAKSQGKVLLSHEEHESLKSIIKAPDLSHVKLKAESHDHVVIPRVEFEQLETLSKDPPVEHLRELASSKNHVILPADKFKTLEQTANEPIEVKAKALNKVLLDESTHKENTSRLAQLESSYESPDLEYLKQKSSALKHVVVSTDEFEDFKQKANKPIKDQALESGFVLVPEAEFESIKKDLEEPLESKAQKEGLHILPISEHNEILEKLNHPTLESLKAHTERSGFAIVAATEFVSLKDAANETLEARATRESMKLLSPEEYNKLLSPTMEAVAIHANAFGHELISSEELHDLKRSFDEPLEDKASKKNLTVITIADLEALNNQIARPSFEHLIQKAKALSYTLVTDEEYSSLATNSSKSLEMRAQEESKKVLTNQEYDDLIFKANMPSLEMIRAKAADNGMEVLPSEELKELREIYSKPLEQRAKEEGLVVISQEEYDSPSLEYLLEKAEESSMFILPIGEFNQMKTTISEPIETKAKKLGKVLVDQVELDQLNESTKLGTVETLLRGADTEKTSIIETFTNEGFKFLPLAEFEKLTTPPDETKTKAIDKPSNNIASSIRANRRISRDGSIFSDENNFVDAEESFLLDEEELSLSAARIGMVVIKDDEYISLLGKKPDEQDVEEYLKEHALVMISEAELLTYKQDLAEKDSKIFELSQKEADITKEVVMTKSAELGLFSLTREEYEQLKKSQIENITGDQISTVAAQFGLVPISKRDLETLQASKEIVSNSANFSKAGKALGYLVLPGNAFIPTTAMREPDTSKVTAIPTSYYTKLLRNEGLNIEKVSDEVFKKNAEKRGYVHEDDILVPPTITSDVESPTPSSKASPEIASVARFATPVRTSTITSPGSKSMAHQPHMSRSNLSIHSNAHSFTDTVNTTGILSMATNVSLTDRSMIPAITQVVIGEFVWKYHRRLGPFTSIRESRHERYFWVHPYSLTLYWSTVNPSLSNPSPAKTRAAAIVSVESVDDNNPLPTGLYHKSIVVHSQTRSIKFTCSNRRRHNVWFNALRYMINRDLNEITFDQESAIFEEDEDGEQEEQDSFYQNAGDRRAYPRKRVSSTPSQLFRQRSSVRVSRFNSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY40</accession>
    <name>G3AY40_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_133175</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY40"/>
    <dbReference type="eggNOG" id="ENOG502RQ8I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044220_0_0_1"/>
    <dbReference type="OrthoDB" id="4025341at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="423" mass="49060" checksum="06E09A83540AADB8" modified="2011-11-16" version="1">MVTSKNMFGRAFDGLFGPSSPLTNEPTIDYNNTIHSFRSQNTSYPRSPASSTNQYPTANYWEDSDEELNNDMSAVYNQLSENSTHISEYLHQASEIPGNFSTYSNEPVPNNAQMSFGPMTSRFENIGKDIVGDRFERIPKSSIFRSSSPNITRHKPSSLDTGLDARYNARRNGRTSTPTHYRSQRDLSVSRDELSTLDRFNSRGPKNDYQSEANIRPNSFKTRKPDENIGTSYSAYDKPFSSYESGDRFNRPRVDNLRDSISRFAKKDFKIFNDSKQEQAKELLKLEQEINQESLTKLNTKFNHTNIKLDQFKTLKSLNDQIVENNRVLSKFDELLKINNDPELRIPDKDNERYNNLRSEYLSELTNHQVFYQNYLKLFQKYKNLKSDKYAKVIAKLELIRDTTEENSIKLICTNLLNDFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY77</accession>
    <name>G3AY77_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_133202</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY77"/>
    <dbReference type="STRING" id="590646.G3AY77"/>
    <dbReference type="GeneID" id="18249677"/>
    <dbReference type="KEGG" id="cten:18249677"/>
    <dbReference type="eggNOG" id="KOG4842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023057_3_0_1"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="14"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="309" mass="34834" checksum="3B344609735BED3B" modified="2011-11-16" version="1">MVVNGGRRPVAKPHERSPPTNRITKIASLKRFPDKEYANSILHDVAKLVAPIMHENNFEVGLLCEMFPKSPNLLGLNINMGQKIMLRLRHHSNSKSFLPMSDIVGTMLHELTHNIHGPHNDKFYKFLDKIKERFEEIQYNPSSVTGYVCEENKLGRGNTLFRDYKSIRDKRIEALGKAKYKSEFRKLGGNSKTGEPRMDPKSLRLRALEAAEQRLRDSKSCNSKEQTQAEPEDDELEIVDVDSLQGLIRPRDISRLTGAKGSIANSTSGPSNLVQTQTRSDIEVIDLTSDTPEAASDSQIRDQDVVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY85</accession>
    <name>G3AY85_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112661</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY85"/>
    <dbReference type="STRING" id="590646.G3AY85"/>
    <dbReference type="GeneID" id="18246623"/>
    <dbReference type="KEGG" id="cten:18246623"/>
    <dbReference type="eggNOG" id="ENOG502RZ0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053002_1_0_1"/>
    <dbReference type="OrthoDB" id="3992718at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="226" mass="25147" checksum="B2EE7DEF8574CAA0" modified="2011-11-16" version="1">MYKLLVINPNSSEKVTNDMRDLLPQVPGIQYDFYTAPAAAPSEIDGEHAGEVSEAVVYPDLIKRKLLDYDGYLVCCYSDHPLVYSLTQSTNKPILGIMLGSLIYSVSNPRFSKSMILTSTSSWNNTLDKSILKFFKSHSFPQSMARTKSFDINVVNLNNPVVYGEIVKKVQLYLDEEPQVNCVLLGCAGMVGLDSKLAKTFPDVRFIDSVRVSAEILASLVRFETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYL4</accession>
    <name>G3AYL4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">13 kDa ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_96961</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 13">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
            <location evidence="1 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYL4"/>
    <dbReference type="STRING" id="590646.G3AYL4"/>
    <dbReference type="GeneID" id="18250643"/>
    <dbReference type="KEGG" id="cten:18250643"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="14">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV65881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="126" mass="13544" checksum="A12E857501C6A20D" modified="2011-11-16" version="1">MSAPNPKAFPLADSALSTQILDVAQQAQNLRQLKKGANEATKTLNRGISEFIIMAADTEPIEILLHLPLLCEDKNVPYVFVPSKAALGRACGVSRPVIAASVTTNDASAIKNQIYSIKDKIETLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYM7</accession>
    <name>G3AYM7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_102444</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGV65892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
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        <property type="entry name" value="PCF11-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021605">
        <property type="entry name" value="Pcf11_Clp1-ID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
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        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="510" mass="58203" checksum="6D23C1EF099FFAD3" modified="2011-11-16" version="1">MSEIVQEYAQSLKELTFNSRPIIDTLTTIAAENTDEGDGILDVITARIYKCLPEQKLFALYLLDSICKNVGNPYNILIGDDIFKLFSHVYLLVDDNVRKKLQNLFETWRLTKAKGTNIPLFPPGELEKIGAFLKKAGPVNNGNELSNSRLIRDIDELLPIFHNKLNNNSNDTKLNERFNALNQLKFLLQNQKMQPNELKAVEAQLNTIKHQELNRSSTSANSSPNSTPTLRSNIPSSLPATPKVNTVPASSANDLFDRLINEGIITFEQDFNSPRVYEINYPKGNPNDHSDVFSSILGYQMIRSEYEQLKYNELNKLKVTSQSVQGFISSPNVSIQCKNLLYESKGLKCSICGKRFNTDDVGKNRKRLHLDWHFRISQKFKSSSNVQSRSWYLDDVDWAKFKDENLLEFQVNIANSTQSSSQFKPQESKEIPYVIIPSTETNMNNKCLICREQVKGSFNEELGEWCWYNCILQPGEPKGSRKIVHANCYNETRKRGALEDAHSGLKRERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYP0</accession>
    <name>G3AYP0_CANTC</name>
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        <submittedName>
            <fullName evidence="7">Orm1 type endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112771</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYP0"/>
    <dbReference type="STRING" id="590646.G3AYP0"/>
    <dbReference type="eggNOG" id="KOG3319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072117_2_1_1"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="189" mass="21847" checksum="7F9508FE778334E2" modified="2011-11-16" version="1">MSKETEFPSTGSANLSPSQSHITRKRRSSSLIQHLEPDTQDTKIDQQLNPNLNADWVHYKGAWIVHIVIIVLLKIFFNFITILDNNWKWTLTNLTYNIGSYIMFHQVKGTPFEFNSGAYDNLTMWEQIDNGDQYTPTKKFLMLVPIGLFLVSTHYSYYNLNLFILNGVSCLCVVVPKLAISHRLRVTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYT0</accession>
    <name>G3AYT0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112799</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYT0"/>
    <dbReference type="STRING" id="590646.G3AYT0"/>
    <dbReference type="HOGENOM" id="CLU_1906479_0_0_1"/>
    <dbReference type="OrthoDB" id="3977264at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="133" mass="15478" checksum="3E096D76A1990B01" modified="2011-11-16" version="1">MKRFIEDDRSPVSEDELREMEEKYSEHNALFGSKDDIFGSINFMNEKVFNFRIFHDTGNKPDKEKSDKSKESGKLESSEATNASTTNNSDNDNNNNDDDNNIPSVEVNDFAKDKKKFLEICEKTWDQFVFDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYX5</accession>
    <name>G3AYX5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_101893</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684528.1">
        <property type="nucleotide sequence ID" value="XM_006684465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYX5"/>
    <dbReference type="STRING" id="590646.G3AYX5"/>
    <dbReference type="GeneID" id="18245511"/>
    <dbReference type="KEGG" id="cten:18245511"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030667_1_0_1"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="607" mass="69614" checksum="6E516BF8753290D8" modified="2011-11-16" version="1">MASISGLLQWCKENGTLLSPRVEFKNIDATNIGGFFQNSEKEAADDLEDEHIRLPLKLAITVSDAIKSFSDGNEADTFTNISNKTSNINSLLKLFLAREKSEKYLSKSFYQPYLTLLPSLTDINSPYTWSPEDKESLRGTNLGSALKENLAALVEEWWQVINLLPESIDKPEQHFVNMKFYYEFKFHQEKDLYELFNTEQDFNNWTSFTNYLWSSLILKSRSFPAYLIKNVDKEKDIKMDEAMLLPVVDLLNHSMKADVEWSVTRTGGTDFFNFKSNSALVGRELFNNYGRKGNEELLLAYGFCIEGNEADTTALKIKIPVEMLPELEQAGVKLPRLSDYTTAVVRTDEPTPDNKGDYSEFSDGLLFFVTVNNVPENLISLFQQLVKTPWETDITLRTKLAGINHLRQALESKITIINEIKKPSAQSANTRNIDIYVSSQKQILNSAVKILKRKEKDILVDPEVKPNLVTLKTVYKKDKKFADALLVSLGVTSYEQLIEHSFQDQAWLLFLIRCHNKKEYADEEENYLPDWIHDSFERMTKEHTITAEEIVQYQELYESLVIPLTSTAPDVFNRGVWTVEQLIISARLLDTISFVRGKKQECILVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ41</accession>
    <name>G3AZ41_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_133432</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ41"/>
    <dbReference type="HOGENOM" id="CLU_1069562_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442771" evidence="1">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="260" mass="28270" checksum="75648ED355A1FE78" modified="2011-11-16" version="1">MKPALLRHLKCLTSLLAVSAAFTITLEDQDHTNDDSMLTWLTTRRPLEIATINDLDPESLYKTGVVIVKDTKSIILPDGDYIDIESFGGGVPIIGDETLFAEYSFKKTVLHTQSVSRPLGSALDNSRSTVANSVSYSVSASSGKTFSLIASVSAKLVLQTAFEAELDISKGTPISVQATCNVPAGKKAQIIAVISLVKVNVEKRLITLSAYKNFSDCLKGLVRANPKSCLKPNFGYELEEWERTELEFVKSVTSKCTSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ59</accession>
    <name>G3AZ59_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92365</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684588.1">
        <property type="nucleotide sequence ID" value="XM_006684525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ59"/>
    <dbReference type="GeneID" id="18250192"/>
    <dbReference type="KEGG" id="cten:18250192"/>
    <dbReference type="eggNOG" id="ENOG502QW4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727829_0_0_1"/>
    <dbReference type="OrthoDB" id="4076003at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="327" mass="37819" checksum="C11A46418FE82BDE" modified="2011-11-16" version="1">MSGNRVHIDRQSSRLDLIDNTTLTSLPFPPPLKSQPSKLSKRSKPDLLANRSRSSPSILDNKALPLELKAARDVTSPLNKDVSARDASFTSIDTLTSQNMTTEIDDSFEDAEEPIIFVEDYMKPQQIPNSQPNFSRQKSLANFKKRLGGELKKRRISAEHEDLEQIFGHIPGKNLLKYCDICDKPLYEMSSLINNKRIKHNKINEWNDVFNEFICFECIDVYEDFLNELYTQEVEREPQTTSSSSMTESKNLKLLNIFKTIQLRSLDKRTIFSNNLISRLQFLNSKSLSTDIGELQELNWITTLQNKLRWRWRLDGLLPSFKRKTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZN9</accession>
    <name>G3AZN9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bud site selection protein RAX2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_96752</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AZN9"/>
    <dbReference type="eggNOG" id="ENOG502QQZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005863_0_0_1"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005621">
        <property type="term" value="C:cellular bud scar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000282">
        <property type="term" value="P:cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442775" description="Bud site selection protein RAX2" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="4">
        <location>
            <begin position="228"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="5">
        <location>
            <begin position="427"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="3">
        <location>
            <begin position="1014"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1349" mass="148163" checksum="258E9535AA4D3419" modified="2011-11-16" version="1">MYKLLVPLLLLLRGARADSSSSISHPSLDYGELGGKLGLLGGFNSISYYSSANATGSLTGSISSIQQLSDDTILINGDFDSFNQQACQPPIIYNLTSNDLTNLFSSASAARRKRDSNNSLPSLNGTVETTYIDGDLIYLGGDFEYNDSHGAVVYNSTSKQLIELPFKGFGKNSSVNAITKVDGGDDNGSIIFGGYFDTLGIPDLLVHNITALNNSTKHSNSTNTSLITAEQKISLKHGTFTDVNGDGSSPSSLICPSTGSSLWAPQDNSGGQWLVTLPSQMQGLTPTKVRLYIPDGADSIDTFRIYSYPNNGIMNLTYVDPDTNEIAYCDASCPLSALSSLKEATQDNLDNIADLDVDDVFIGEDDGTFSMYYDSSTQTKTLSYGKNFQEFAFENDVMIDQIGLTVISWHGSKGAVAGFELYSNSIFVYGNETLNEPDCDEDPDKTNKIEINSGSFDSIASIDSSLVNMDYQVSTGGDGKVTLYPNISYSGDYSIIMITPGCISDDSCDLRSIVNVTVYDSEDELLARKSIYQNNNYKKFDYLFYGHLEGSTLSEGQTRIEVEFDQAIVEGTQEPWMVIDKIRADIVELDDYYNTNSTNHTRTKNGTYSGLVELKINGLFEYSLANFSSFNEDMIYTVDDDISPDNLFVGNSTINVLSSELSNDTVVKQFNADNGTLLVLGSFSSNSSNLTLSNDNLINFKISKYNTTSNFTVADIQKRSKWGNFDIVDTGYHTTNYLLSSEDVYVDLVTRADVNSSTIFGGTFNNSITTVSSYGSARVFIGRFQMTNQDDSGVEILDLSNGNKSVDEANNFVLYANEDFYSFGNDFIDETFDTFTFITLPSAEYFIFSSSEDTRTWDNSNKEWITNPNRQLNITEVITLSDGSQIVSGSSFNPMDNYFTNQAYFTSNDDVSNGSFDTFNIDLDGGNITVSYYINDSVSVIGGNFQTTSKTPIVDVGFLSTKDNHSFTGVQGNIEWTSNATIQTVYVDSNDEYLFIGYNNSVSVNGLSLSGGVIIYDIKSNNFTSFQPAELSNSAGGLEVNAIVYYENGKKLLVGGNFDSAGSLDCQGLCIYDIKNTRWESPNSDLDGNYVSDIKFIKSNEVLITGALSLENKDSKFAVYNLDKDEFDSAPSSLNNLSSDDVPTKLIMSDDSYDDDLKGRFIVVGNGFIKGYNGSEWSDIEGIDFSNETRLADVKLLTLKKSNSDNDQTYFSKNQILAVAGKFKLQEYGLVNVAFYDGKIWTPLAYTTLTGTQLGSVNSILVKDQFRYLSSADIENKSSKLSSGKVVGISLACALGSTTFLSLLYIIPYLALFRKNKENETTERIGEKEMMDAVNPEELFHEIDLQRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZZ2</accession>
    <name>G3AZZ2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_133582</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZZ2"/>
    <dbReference type="STRING" id="590646.G3AZZ2"/>
    <dbReference type="GeneID" id="18249722"/>
    <dbReference type="KEGG" id="cten:18249722"/>
    <dbReference type="eggNOG" id="KOG2486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062874_0_0_1"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="5">
        <location>
            <begin position="117"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="335" mass="37389" checksum="E7C9C544D2C73A56" modified="2011-11-16" version="1">MMQTHIPQHVRTYSISYLTESIPPPPPLSSPHPKLISSVNHPKTVSHLIVTPKSLTNTFRHQDYAPVSGQLLNVTQKLFLGAKPRLEWTLADYKEIPDIKAIAKAAENPAYKFKAPILPEVLFLGHTNSGKSSLINNLLLNSKDSRTLGASTEYAFVSNKAGYTQTMNCFNVGNRFRLIDSPGYGQFGKEEQGQMVVEYIERRKVLRRAYLLIDSSHGLRDEDTQILGLLVTAGAPFEVVFTKVDMVILKIMKAHGVITKKVVDLASREANVLAVEHANAEVVRYYESLIENANLLNLPTLPRLFFNNAVANKMVQGRWGYKEIRTSIVESCGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0B8</accession>
    <name>G3B0B8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_113085</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573</strain>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0B8"/>
    <dbReference type="STRING" id="590646.G3B0B8"/>
    <dbReference type="GeneID" id="90981935"/>
    <dbReference type="KEGG" id="cten:90981935"/>
    <dbReference type="eggNOG" id="ENOG502SG7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138063_2_0_1"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV65523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="119" mass="13383" checksum="E416C8E2AD232F22" modified="2011-11-16" version="1">MQKSGQIYQKIDEKRAELASLTEIKDYTERLTSQLEVLETKLEEMVDGAESVNLVLSTWQNVVRSISLASLGLYKYSQNDYESSTPLPEGLLRIKVIPEGEDDVDVDEVNADATDTRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0G2</accession>
    <name>G3B0G2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113115</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685082.1">
        <property type="nucleotide sequence ID" value="XM_006685019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0G2"/>
    <dbReference type="STRING" id="590646.G3B0G2"/>
    <dbReference type="GeneID" id="18246829"/>
    <dbReference type="KEGG" id="cten:18246829"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF24">
        <property type="entry name" value="HYPOTHETICAL FRUCTOSYL AMINE:OXYGEN OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="434" mass="47919" checksum="36219D45A17B6A35" modified="2011-11-16" version="1">MSSPKDKDVLIIGAGTFGLSSGLWLLRNGFKSVTIIDPKPLPSTLSAGYDINKIIQSAYPEDAAFTASLAVEALEGWQNDPVFYPHFYETGIVYATSQGEPSAEYEELESVRNFTKSQNRKHETVLLNSPNEFRAVVPQLTGSLANWKGHYQKTECGWADAKSALVSAGKEFARLGGQYVESEVARLLYNADNTAVLGCVTSDGRKVFAATTIVAAGASSVKIMDFEDQLLAKCWTVGHIRLTPDEAASFKGMPVVCNLEKGFFFEPDYTKNELKICNEFPGYTHYVGDSTAADSSVPVYKNQIPHVAERDIRLLLQETLPQLADRPLVQAKICWCTDTPDRNFLVCEHPQYGETLVLATGDSGHGFKHMPSIGKYVARLVMYGPGGLDCEKRTKWRWRPETAKDRIQDRFGGDGHVNDLKDITDWVSAISIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0H4</accession>
    <name>G3B0H4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D123-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_97301</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685089.1">
        <property type="nucleotide sequence ID" value="XM_006685026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0H4"/>
    <dbReference type="STRING" id="590646.G3B0H4"/>
    <dbReference type="GeneID" id="18250677"/>
    <dbReference type="KEGG" id="cten:18250677"/>
    <dbReference type="eggNOG" id="KOG2983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034402_2_0_1"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="331" mass="38598" checksum="3D953A152D6F7BF3" modified="2011-11-16" version="1">MTRDYTVFEEVKATKKDILNCRFSSWYPKLQEHSFEAEILGPLPSQFVEYLGAESIRLPLEDKVELDVTSDNEYSDWEDEEDSAEESDPIQGFVDLHEQVNEVVKKYRAVAPKLNWSAPKDSCWIMLNKTMKCQSASDVYLMLNASDHITHDLDFPFEDTHDEESDPEFDYELVLRKWRDINPALEFRVFVRNGEVVGKSQRDLNYYDYLEKLIGDNKLDDTINSFVKKTVVPVIENRSFIVDVYVPKPFSKVYVVDINPFTRITDSILYTWSELLNDKEDKTRLITETNIGRFKTKAYSENQVPLDVIQASSDPNSLAQLAREWQINEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0N7</accession>
    <name>G3B0N7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_102685</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0N7"/>
    <dbReference type="GeneID" id="18245571"/>
    <dbReference type="KEGG" id="cten:18245571"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001371">
        <property type="entry name" value="ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="49"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="385"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="640" mass="71356" checksum="487E455C486276F6" modified="2011-11-16" version="1">MRRSEHENLDNAKYDKDKDNNNSKRKTTGSDIWNLLLLAKPESRLLGYALTMLVVTSTVTMSLPLIVGKIIDNARPLEALSIEERVAQVGNSTFILGFTETQFYSAVAVLFAIGAVSNFGRMYVLRMAGEKLVARMRSRLFSKILSQDSYFFDVGPTKKGMKVGDLISRISSDTQIIARSLSGNISDGARAMISGAVGISMMCYVSWQLTLFMSIFFPPLIVMTFVYGGRMKQLARKVQENLGDLTKVTEEKLNGLKTIQSYARQNLVVHGYNKEVRNLFNTSMRENKLSAIYFSTNSLIGNMMIIGLLFVGTRLISLGNLTIGDLSSFMMYAAYTGGSVFGLGNFYTELMKAIGAADRVFELTRSEPKIKTTIGKKVDDLEGDIEFKKIEFSYPSRPKSKVFRSSNLNLTIKKGENVCFVGPSGSGKSTIAQLLLRFYDPNKGSILINGHDIKDLNLNFYRSKIGYVQQEPLLFSGTLRENITFGKDHCTEQEIETAIRLSNAYGFINMFPKGLDTLVGPSSSGAQLSGGQKQRISLARTLIKNPHILVLDEATSALDSISEELVMRNLKRVTAENGYTMISIAHRLSTIKNSDRIIVLSEQGEIVEDGPFTQLYQDKQSRFNELLRKHDHDLTEVFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0U8</accession>
    <name>G3B0U8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_93045</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685613.1">
        <property type="nucleotide sequence ID" value="XM_006685550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0U8"/>
    <dbReference type="STRING" id="590646.G3B0U8"/>
    <dbReference type="GeneID" id="18250250"/>
    <dbReference type="KEGG" id="cten:18250250"/>
    <dbReference type="HOGENOM" id="CLU_1786593_0_0_1"/>
    <dbReference type="OrthoDB" id="4084730at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="145" mass="16768" checksum="1B3E811210D3CA0E" modified="2011-11-16" version="1">MFRQAITIFQAQKLNLSLLNKLNSYNIKVVLKDKPCYQDYKMIHNSFLHIHPDNLSILVASYPELFKASHQNSKMYLNDLNMVSAGEFNRLKFNGPLVFDANNNLLANNDLTISRLLSNHDPMAHNHINLHNLVHPHRAEFADLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B133</accession>
    <name>G3B133_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_97686</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685674.1">
        <property type="nucleotide sequence ID" value="XM_006685611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B133"/>
    <dbReference type="GeneID" id="18250703"/>
    <dbReference type="KEGG" id="cten:18250703"/>
    <dbReference type="eggNOG" id="ENOG502RQ23">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103818_0_0_1"/>
    <dbReference type="OrthoDB" id="3997851at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="166" mass="18017" checksum="F8293BA1EC8B1C4E" modified="2011-11-16" version="1">MQGSYKNNGLPRPYYMKPVKGKGKKGSPYESMQSNYFSTPKKKIIGYLFMLCFFSLSFYWLGQSMRAAPDAEYDIDIGQASTKVGINNILGVVENDKDSSNLGLAGNLAVGSKGDVGIGVNEAPKGGMANEAPVVGNDEDEVIEGKKKQKPVDDHLVDEDSILKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B185</accession>
    <name>G3B185_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_113665</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B185"/>
    <dbReference type="STRING" id="590646.G3B185"/>
    <dbReference type="GeneID" id="18247074"/>
    <dbReference type="KEGG" id="cten:18247074"/>
    <dbReference type="eggNOG" id="KOG1321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_1_0_1"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="382" mass="43601" checksum="9D253DEC86C9E8B0" modified="2011-11-16" version="1">MLKRLVPTTTRFVRWNSTAIKPKTGVVFMNMGGPSTVKETHQFLFRLFSDADLIPLGPFQNIAAKFIARRRTPTIEKHYEEIGGGSPIRYWSEYQSKRVCEILDKTSPETAPHKPYVAFRYADPLTEETLVKMKKDGITRAVAFSQYPQYSCSTTGSSMNVLYNATLELDPERSIEWSFIDRWPKLDGFLEAFKEHIEQKINEFPEENRKNVVVIFSAHSLPMQIVNRGDSYPAEVAATVYAIMEKLKFKYPYRLVWQSKVGPKPWLGAQTAKIVGKLERDEAIDGIVLVPVAFTSDHIETLHELDIELMDDLVYPEKVKRAESMNGNETFITGLAQLVKDHLASGEYHSRQLELDTILGREFSANSLHHPQEIFGPAKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1L9</accession>
    <name>G3B1L9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_104274</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1L9"/>
    <dbReference type="STRING" id="590646.G3B1L9"/>
    <dbReference type="eggNOG" id="KOG2762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035382_3_0_1"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="454" mass="51585" checksum="D92F6E2E88E36FB8" modified="2011-11-16" version="1">MPPTEGNRPQELPEFTLKNVLTDIYNAIYGLLFDPDYKRLVGPIIAIVTSIGTKVIIAKVPYTEIDFNTYMQQIEVVNDGELDYSLIKGDTGPAVYPAGFIQVYQFIYWLTNNGTDILTAQTIFSYLFTLSVIMAMFTYTGVRPWVLILSVCSKRLVSIYVLRLFNDGFTTLAMIGVTLVLQQTAYWYATLGPNLTFAATCIAADLFSMAISVKMNALLYLPGFIVVIYFLNGENLLKSLTTLLIIPLVQVSIGWKFLLPLFNDEMAKYLRWTYINQAFKFDRKFLYEWTVNWKFVSEETFLSDEFSNGLLIGHASLLLVFCFTRYLSPKVTGKSVAVLIGDFFKVFASTVSKDNLLLNPDSGPRLVMLILSTSNVIGVLFARSLHYQFLSWYCWQLPFLMSTANPYLTIPFWFAHEYCWNVFPATAESSILLNVVLSLTLMGVWANTSAWFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2G8</accession>
    <name>G3B2G8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_113463</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2G8"/>
    <dbReference type="STRING" id="590646.G3B2G8"/>
    <dbReference type="GeneID" id="18246970"/>
    <dbReference type="KEGG" id="cten:18246970"/>
    <dbReference type="eggNOG" id="KOG2700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_1_1_1"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="482" mass="54293" checksum="61CC7DA1DBBB8E40" modified="2011-11-16" version="1">MSSYDKYATPLSSRYASDEMSSVFSLRNRFSTWRKLWYNLAIAEQQVGLKVITDEAIEQMKNHLEITDEEIDRATKEEAIVRHDVMAHVHVFGEVCPKAAGIIHLGATSCFVTDNADLIFLRDAYDILIPKLVNVIDRLSQFALEHKDLPVLGWTHFQPAQLTTVGKRACLWIQELLWDLRNMERARNDLGLRGVKGTTGTQASFLSLFHGDHDKVELLDETVVKLLGFEHVYPVTGQTYSRKIDIDVLSPLASFAATAHKFATDIRLLANLKEVEEPFEKSQIGSSAMAYKRNPMRCERVCSLARHLGSLMNDAVQTASVQWFERTLDDSAIRRISLPSAFLTADILLSTMNNITSGLVVYPKVIERRINSELPFMATENIIMAMVEKGGSRQDCHEEIRVLSHQASAVVKQQGGDNDLIERVKNTKYFEPIWNDLGKLLDPSTFVGRAPQQTEKFIKNDVAQALAPYGHVINRAPVHLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2J4</accession>
    <name>G3B2J4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="7" type="ORF">CANTEDRAFT_113480</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2J4"/>
    <dbReference type="STRING" id="590646.G3B2J4"/>
    <dbReference type="GeneID" id="18246980"/>
    <dbReference type="KEGG" id="cten:18246980"/>
    <dbReference type="eggNOG" id="ENOG502QUN5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026505_0_0_1"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="427" mass="47087" checksum="E3F1F6FDFF3321B2" modified="2011-11-16" version="1">MEYLQKCFYKTTGWSEDNIFPNITSNSQAILDFSIPNGCKLDISSKSSDYSASSFTLSNYNVINGSLAYLYSSIPLKNTLGTKNMSLQEALSGFKIIEPKELETKSEFSAVPSDISKPSLLYGRMYFPGSALEAMVIKRISKSTQLLIKSISNPNLSKNGTMIIYLQNNTSKLSREFIYSTNEALIGFRCLYNFGQNEKTSATSAKFSGQHLPIIPKLDNSVVSIGTEIWYAAMTLSPGLSTAFRYSTRSTTTGKPLTMTIACNPILGQLSSTYTVKTSVASTFSSRYEFNLYSYASNLSLGFELYNLSKQPSPYNDTDAIVNSSMKISPNSQSITISPGMSSIDVTGPEPPIHKQTVMAVFQNLVKQSDFSSVLKFSTSLNDRMIKLLWEGRCKDFLVSAGTRISLNPNTNQPEFNKLGVSFSYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2M6</accession>
    <name>G3B2M6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_92954</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B2M6"/>
    <dbReference type="GeneID" id="18250241"/>
    <dbReference type="KEGG" id="cten:18250241"/>
    <dbReference type="eggNOG" id="KOG1826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000439_0_0_1"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05392">
        <property type="entry name" value="RasGAP_Neurofibromin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="2711" mass="310666" checksum="39E40775387CE055" modified="2011-11-16" version="1">MDQPHGRQPLQNDSGYNAQLEFINSLTHRLESFLPNVTGYSLIEVELNPQFKITKDLLIDRTKFDLKVYGMDYISICFMKLCNIIESINKDAKEVKLKDRDEKQLSSTLIILKILRELIEECWLSRTALSNFKSDVNLMNFEILTNFSFYYHFTPPKPINVNYINLIIDILGSLLSGEVIKRVLSMIQKRPIDGKGYYNSHSSNSDTPSSVQSIVSGASNQQNPQTQLGHNRGPSLMEDPVLGSDSPIYSSEHETAKLIQELDFNIEICLRFIATSNPLQYYNYLYNNLFKFSVSNEVVPPYNLQKYAPLIKYTFYSLENGYAMANVINKSLESIKNTTWKQIILVFYSHSVRDQAFARPEDYDAIVESSSEVAAICKSIFDQTCSIFEEFPYAGIASMVQTWVSMLNPSDYREYELKPNKLKLSFNKRLKFINNLIKNSTNRSNLTCFDSLITLYHLAARFPSNMSNHPVYIFTMSHLDETYEALVKVNLSTFSINLNSPNSDYVKICYDNLIVNFFIAAIMLKPEKYCNLLLNRFQSIKDSYRDVRIIVKVVRGLSEYTLSLKSFNQIMTSISPQLKSLSSNVSRLLSQYYENSISIHTSSSSASVYSDKASVSSSTQNNTRKLSFDQELSPHSSRILAHHHSHLQQQSVSSQQLSSHPQTISSSSFHDINVDELKFSSASISAAASTGTSKLVANVEDLLADLFAIFKASPQLFFNDISFMEPEIFYQDEDASRARILKFVQDNVDSLRVGLQSRSMNNTDDSTLFSSTCRLIMSIVDKQSNMTSNLNIVTSFANYSTCKQIVKSICDSCLSLSLTDVKFKSNLIFLNEFLEMREEFNKIVTKSPIVQDPRSHCDETDVGNSVERILLLSLCTHDIQFYNIVKDTMKWHLLHVKRISTHFEHNLADTFEKLVQDDFVFTGFVSLHKRFRNILRESRPTKALYQVWLIIYERWCDLLFNKIASLNEENLLFRHFTGFLVSTSGCFLSNEFADGDPVLRSKSEQNISNFFDRCINLLTSSDLVIRVIIKDALSNESHSAVYQLVSNKLVTVVNKFEENKNIYEESVLFTEQTIMIMTSMLSIPNEGAVVLTALLPEICVVLIKLINLVEDPVNQLRLKLRFCKLTVTIETNRKRLLLTGAYKIRNFYAKSTCDWLEQSAFFDELPGPVGNQTGFNYINSYKSSNSSTKSTNKDSELVYLNVDLATESSKALALQLEDLLLDIPEGTSEKDVPKYKDLSFANYFSLFYRILTKYTMNNSGNVKSKYKIQAIVDNVLKCITNILQYDTDIGLQLVFPLGYHDNKKIRALFLSVFAEMLYERKIIRKKSKDFTEINLLGIGSLTDILTSASVIASNQNHNLYASSLFGVYGYLHKLDELFENLLNEEINNVSRTADIFRRNSTLTKLLAKLAKDDGMDYLTLVLKDFVQEFNDKEINFNVEKEQDSNSNPDLFMSYLNNLVSLICDSADSMPKSFRYVCSQIYRKVNAKVPDASLIAVGSFVFLRFFCPAVISPESFFEIDVICHSNKKSLLQLVKVLQNMANKTLSVLKWKSLNQKMDELMQIQRKIFKFLQDVSSYDSTEYPFEEITEMPIPELRYVHKFFFTYYKEIKQNFLLGEFSSDELKKRVEQMTLCDDILREVGQPKALLTIQGGDGGGYKNFDPTGTVSSEYTEFMNRMSAKYADKAIDVSLIHNAIFHDGTPVVVVNLKTLTLVDFDVNLLVYKLFETASQVWDNKFYFVFDFTQFSTEMHVLVTYATLLNTYGPSQLFKNCTRIYYFNLPIKNVGTFFNLVKPSNVEDKEARARFYTYSHCDSNDIISSLCLSEDTMAITRDKKVEFLNCKVLDSTTQSFYSATIKIGRSFFLICSDEFIATNHELCATKGFRPVDIYSLSDITRCEITKSSGATDEFTIYFNSGQSVIVRSHERSEILRFMYFTTSRLPKPYIDEEDRNFQGDVSNLWFGRLFNIVFQSLLCEDDEVRSSASYLFASVGNYFEIEYSISKNHAKDIAYPANTTDFIVAVSKYLSRKFPEMSYRFFRSFFDCYDKLPSRHRINAILYLSPWLDNICDYIYLKDEQSGPDRVAGIIRQVCSISALNKDTISAINDYIWKKLFAESILTPLLLDEIVTFTMDNRNDDPDWSFIISVLSPSVELCGETITRLITCINEATNNDSEIAAESKLFEIMILVKICASLFFDSYIFAQLYLADVFFICSLFIDNPSLEFGGDLQKLVINTIQSFFNKPDLTEIEEKTVEETLAYFSGQRAKMLFGLTREKTTATSDINQLYNRAASFETLCDYLNEFITVLGSADDRSGWRSRWCSYAMDVAFSNSSLFQFRAILVVGILSKSGISDHTATNMLKLMSRTSFNNTLESMTNVLMSAAKIFKGLSKDSVFPSIIIWPELYLGMLNYSSLYQVSIQCLLNTLLKNYEQGPGFVDRVFEQRKHLESFIESFEKSHGFHIDKKNILCYVFFIFTQGLKLSHIKHTSLTCMKQVFKERYVIEAKDEYEVPSGSLPYLLFIWLSTNESSFSEYIATTEYQPSEWLIIHNLNAPKVIIDYLLSDQVYPTLALYQAAYIYATTTVDSGFKTRFLILLNQIFSINPRKGQMIFHIIKSELASTMINSNSTDTVIVVSEIMTQIMSDPTYSLEEHSNATDEFLKENGMMIMKSYRFRKLSDLLASDETAKEKIERDNERLQEMIYRSASSYVENEKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2R1</accession>
    <name>G3B2R1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic amino acid aminotransferase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_120671</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2R1"/>
    <dbReference type="STRING" id="590646.G3B2R1"/>
    <dbReference type="KEGG" id="cten:90982291"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF2">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="114"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="510" mass="56958" checksum="FA2D73A8FF632E83" modified="2011-11-16" version="1">MTVSSEYSLEHLISKRAAGRKKIHFATALTEGAPHGYIPHKEPLYMSGGMPNVGFFPVDSISVGVADYPFQKQFELTHSNGSLEALSKDLKKLDVQAESTKKVEIAKIGTDKNLIDIRQGLQYSHWNGMEQLLEFTKDFITRTHPPAHSDWSTILTTGAGDGILKCMDSVLDKDDVVLMEEFTFTPSLMMIRETGATGVPIKLKVSSDSEGIDLEYLTDLLENWETLKPGLKKPKALYTIPTGQNPTGLTQSLEFRKKIYALAEKYDFIIIEDDPYGYLTLPPFKQPEGTQSLDEFLTVDEYIKDHLTPSYLEIDTSARVLRIETFSKLFAPGLRVGFIVGHKRLIDVIAAYSVIVTKFPSGVAQTVLQNVLFQKFGGVEGWLQWILKLRSAYIHRRNLLLHELTQASAYQKGLIDVIDPQAGMFVSVVLKFPEGTDVSEKITLLNWKFSAYGVSVVPGLNMAVDKEFSASRGNFYRLTFVPLNTDAEVIEGAKRFAAAVDDFFAKGLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2W7</accession>
    <name>G3B2W7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113555</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2W7"/>
    <dbReference type="GeneID" id="18247017"/>
    <dbReference type="KEGG" id="cten:18247017"/>
    <dbReference type="HOGENOM" id="CLU_119822_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047741">
        <property type="entry name" value="DIP1984-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038048">
        <property type="entry name" value="DIP1984_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20935">
        <property type="entry name" value="DUF6847"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="197" mass="23181" checksum="C7F36E13F9FD152B" modified="2011-11-16" version="1" fragment="single">KITLVKGRIKECAKVQEGDDSPENPYDLLDELHILDFKLTKLITEINLVNFEELVELPSFLEKDCFDESFYKSGFKYHKMEEEEEEEEGEVKPAKKTLCEALSEREPSKRRIELIQFAISAGSVADNFNYSKSEIKIISLINSIKLQKVMNKLREHSRIMDTKIQELNWEVDFEKVFGTIITRKTAGSWKVRRWYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2Z8</accession>
    <name>G3B2Z8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_122085</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686359.1">
        <property type="nucleotide sequence ID" value="XM_006686296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2Z8"/>
    <dbReference type="STRING" id="590646.G3B2Z8"/>
    <dbReference type="GeneID" id="18248878"/>
    <dbReference type="KEGG" id="cten:18248878"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="77"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="542" mass="59569" checksum="E56572F1E6D94109" modified="2011-11-16" version="1">MTTWIDVRDTKIASQQQLLKPFLAPEKLVPAPEELNDVSDFIDTSSVISNDIKYITNLDIPALLAEYSTGALTARQVTEAYCYRATLAHQLTNCLTEIRFQEALHEAEKLDEYYQKHNCLNGPLHGVIVSFKDNINIEGVASSMGFVGEAEEIKTESSTFAKLLTGLGAIIICKTNTSAGMIYSETTNVLWGRTLNPFNRRYLNVGGSSGGEGALALLKGSCFGIGSDIGGSVRHPAALNRVYSLKPSSGRFPKFGTVSGQEGQESIVSVYGILTRSFTNLDYVTKSIIENKPYLQDASCLPMKYTPAKLPAKLTVGFMKSDGLTTVTSPLIRGLEIVKEALRKEGHTVLEWDDTYFKEIRDTIYPFYGADGMKHVKSILAKYNEPPDSHIVASLPVAEDMQVSDLWQSQKKRAAYAQKYLDLWNNGGGPGVRLDAVICACSPYPACLWNKVTPQPLNSIWNALDYSAGTFPVTRCDVSIDKPLEKTSFISDTDKLVHQTYSSNLDKFEGGPVSLQVVCGKLEEEKCAALIGYVSELLDKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Q0</accession>
    <name>G3B3Q0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_93729</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686521.1">
        <property type="nucleotide sequence ID" value="XM_006686458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Q0"/>
    <dbReference type="GeneID" id="18250318"/>
    <dbReference type="KEGG" id="cten:18250318"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="518" mass="58097" checksum="DCDFFE7A3635B81C" modified="2011-11-16" version="1">MSASENSSTKKEKLVVAVSEVGTSDDLELNSSIVSNAQDIAAKYGNILQGGYTKQEARKILWKCDMFLIPFLWLNVTFGAMDKVSTGTASIYGMQTDLGLVGNQYSWIGSAFYFGYLFWCFPSGMILQKLPVAKVSGACFFVWGIIIIGSGFAKNFETMVACRVLLGIAEAPIVPLNLIIMSTWYKKGPEQSIRLGLFYTGFSTIFTGTIGYAVGGYTNVAYSPWRYFMWIIGALSSVYGILEFFLLPDSPVNCRYLNEREKAIVIDRVRKNQTGVKNTKFKKDQFFQTLKDPKVWVMVAIQLFISIPNGGLTNFSPLIVNGLGWSSRDSTLLTMPTGIMQTVSVYMASGSLALLEKFWPKKHFRGAVLCFYLIPAFVGTGCLYKLPLTWYTSRLVSLYFGFFYLGSYIISLNLIAANHAGFTRKVTANSIYFLTYAVSNLIAPQFFLTRQAPTYSLGVGAIFGAYALTICAVCVYMFLCWRENKRRNTLYGEAEIENRDTDFSDLTDIDNMNFRYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3U6</accession>
    <name>G3B3U6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_93249</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686051.1">
        <property type="nucleotide sequence ID" value="XM_006685988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3U6"/>
    <dbReference type="STRING" id="590646.G3B3U6"/>
    <dbReference type="GeneID" id="18250268"/>
    <dbReference type="KEGG" id="cten:18250268"/>
    <dbReference type="eggNOG" id="ENOG502QUGB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538593_0_0_1"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12453">
        <property type="entry name" value="RRM1_RIM4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034352">
        <property type="entry name" value="Rim4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF6">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 35 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="121"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="304"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="506" mass="57325" checksum="DA9DEA944FB83FC4" modified="2011-11-16" version="1">MQFRERSEERKDDIKRSDIPSAISQEILESVVVSGADLRSVSKSTGKNTTKEHLQIWEENTNTARSTITEISTVSTSVSSSNDTRTSRNTNDTGITTGKLETPFDFNKENEPSSVRGKPSACVFVASLCSTKSDDVLGAAVSNHFSKYGQVTNIKVLRDVRNRPYAFVQYRTDEDCHRAIANGHNSLLHGRKLRCEAAKVNRTLFIDLSTPRSQSEVRKVIKGLGETEQMLAADKHGVPLQFETFSQFWFIKFVYRDDAIRAFASLSCERYYHIEWAQNIEEKAFGKRDRPGKTPVPLMGFDKYSVFVSHLGNDVAAADLRERFSRHGSITNVQFISRQSKLNGSSFAFITYEEEVGAARAVEIENHSMLKDKNIHVQYKEIHHKHNNSHNKNPLGVQLAPPPINMLKRVKPFHTQGGPKNFNMYKEPKGDSVTRGVENSHYYYVYNNEAPRFFPSTGPNHVLNKNQNLNPDLDTDTSSSSTSSRTSESIRNNTDPALYSYYYYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3V4</accession>
    <name>G3B3V4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113781</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3V4"/>
    <dbReference type="STRING" id="590646.G3B3V4"/>
    <dbReference type="GeneID" id="18247119"/>
    <dbReference type="KEGG" id="cten:18247119"/>
    <dbReference type="eggNOG" id="ENOG502S74C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166990_1_0_1"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9713" checksum="D7291F3CB18A6DA1" modified="2011-11-16" version="1" fragment="single">MGVADKVYGEYPVYFKQPIRWLKYHAHTKPHFFWSIAFGLSAPVLLLATPIRRKYLWADHEPIPRTYPLPNRPRDKNLSGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B450</accession>
    <name>G3B450_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_105711</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B450"/>
    <dbReference type="STRING" id="590646.G3B450"/>
    <dbReference type="GeneID" id="18245833"/>
    <dbReference type="KEGG" id="cten:18245833"/>
    <dbReference type="eggNOG" id="KOG3169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077754_0_0_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.580:FF:000004">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016612">
        <property type="entry name" value="Mediator_Med6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013286">
        <property type="entry name" value="MED6_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="198" mass="23150" checksum="2C44DA67291D60A4" modified="2011-11-16" version="1">MSYGELDEIQWKNPEWINQFGLNTGNVLDYFSESPFYDRTSNNQVFKMQFQFQPPPPNLNTPLEYTKYFESKLSDMVGIEFVIAYIREPDFWIIRKQNRFSRDNVQILQSYYIIGANIYQSPKLYRLISSRLLNSTYSIKTAINLLNNLNEFKHDDDKADTSSNGNSTTQTPFTPAVTQPKKEINFDSILDDALNHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4F5</accession>
    <name>G3B4F5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_130203</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686126.1">
        <property type="nucleotide sequence ID" value="XM_006686063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4F5"/>
    <dbReference type="STRING" id="590646.G3B4F5"/>
    <dbReference type="GeneID" id="18249428"/>
    <dbReference type="KEGG" id="cten:18249428"/>
    <dbReference type="eggNOG" id="KOG0573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012368_2_0_1"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="474"/>
            <end position="475"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="626" mass="71768" checksum="8A46E164EAF2F0EF" modified="2011-11-16" version="1">MCGILCLVNTEFQGHPPCLNNQSSVWECQDTVKIRNIFKQDFRLSATDLNKLNNQEKLKQLNNQLIKLGNNVKVDNSEKIDEVFQQIKDITEEEPEDELTFSSSIEEYNHLIPAIAGRGPDYLQYNKFDLGDSNVQLFSSVLSLRQPFISQPVFTDRYVVQFNGELYNSQCEFSNDTEFLLNQIVKHGIKKALVTLSGEFAFCILDKFEQCVFFGRDSIGKRSLCYKQTKDEILISSVPQRLYSECEGNKLYKFSTQSYKLEVSLLTREFEELVPFNILNYNEPTTQVNRIYESLKRSCFIRQETICPLQATEASLAVLFSGGIDCAVIAALLIENFLELKTPVKIDLLTVGFDNPRTGVKASQSPDRQLSFKSWFHLAKKCSGTNVSLRLVQVDVDYKLWLTHKKNVVSLMYPQETEMDLSIAIAFYFASNNIVPCQKLELQNYEVSWSDFISDTNKYVRVEDYISSAKVLFSGLGADELFGGYSRHEAIFSSLKPDDDPSRQYEELNKQLLHDIEIIHKRNLGRDDRVISSWGKELRYPYLDNEFIKLVINSIEPNYKIKLDWAVTKKGKTISKPTRKWILRQLAGTMGLNFVKDELKRAIQFGAKSAKLEIGQAKARGTDELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4H3</accession>
    <name>G3B4H3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_93337</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4H3"/>
    <dbReference type="STRING" id="590646.G3B4H3"/>
    <dbReference type="GeneID" id="18250277"/>
    <dbReference type="KEGG" id="cten:18250277"/>
    <dbReference type="eggNOG" id="KOG4484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066912_2_0_1"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="58"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="235" mass="26953" checksum="10FC2348C762FDED" modified="2011-11-16" version="1">MPSKGFINKKGDRNPGSDVSKVLASGSGKIKKKIRDIHRLLQRPTLPADVRVNNERTLKALEVQLNNVVQKSNEKKNAKKYHMVRFFERKKATRLVKQARIALSAAEESNDRKAAKKARVFLKHKEIDLVYTVLFPKMEKYISLYPNSKNEDESSLPPKALEGMKRADQRRIEFRKHIEKLMKEEKLPFSLEDVLKGKKFEADQGTAVTDKQEIDAPQKKSQGSEVDEFFEDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4S8</accession>
    <name>G3B4S8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_93367</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686178.1">
        <property type="nucleotide sequence ID" value="XM_006686115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4S8"/>
    <dbReference type="STRING" id="590646.G3B4S8"/>
    <dbReference type="GeneID" id="18250283"/>
    <dbReference type="KEGG" id="cten:18250283"/>
    <dbReference type="eggNOG" id="ENOG502QRPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_344831_0_0_1"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="793" mass="91463" checksum="BB5CBCCDF538684B" modified="2011-11-16" version="1">MNRYKPKRMRPINACVSCRTRKIKCDKGQPCSKCSKYGGECVYQPFDFLPREANEQVSVGEDLSLLDSQEVEKQIAEAQMNIANLEKELTSAKSLVARSLEREISSTGSTPSSPFSSTSSSSTTNISSADKTPTAYLAIPLQQRQIIGLDDPVPFEFSEAERKLEVNIFDLYNPVKTDGVIRKQSPPLSWMSFINCDRFLNAMQQAVYKDLSLDSKLNFLNSIADAGCSEATERLFTMKYHDDEDLDDFKPIDEADLNPSLLPLGLETLNSNVFPMGDYVQPEFQLSKQICQFLPDRRIIDMLVDRFFIYLYPFIHVLDQHDFLNQVDRILKDLDRGQVVIKDKFDLTQIGILLIMLRLSYVSLYTCNKSLNESNLMQNLKFEEEDEDNVRFLLKHPIDLKAVDLSQQCLNKVGLFSTLTLSNLQLALMIRSYQKYGPEYILGSGENEPYSFDVIISILAQKLEVFHELGPKLSERERNLRRKIGAYLISLSLLNFGALNCVKNFKMAICNIQIPEYTKENSNNFNENTERITLQILSSILSPGQLYSDTQSLFENYSSPNFEKASQGLIDSYEKTFTPLLIRRAHDKYTICIINTLTIRSRLMRCFVKLSIKFHLYNSLEDRTLTHKLLDDMLQIIFKEMLVLCKAIFSKEGCFANTIDLIFIPSLIHLIHRVLLIITGMMIRLNLILNKFKRQSINNHYTHNCEHLLGLFNKTNAVFFKFLLNLSNRYYYGWRVFKTQNYFIRCINLLELRSIFKDVDISENFKFTNNWVLQISELITHQLNDDQSPSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Z8</accession>
    <name>G3B4Z8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114061</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Z8"/>
    <dbReference type="STRING" id="590646.G3B4Z8"/>
    <dbReference type="GeneID" id="18247241"/>
    <dbReference type="KEGG" id="cten:18247241"/>
    <dbReference type="eggNOG" id="KOG1909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028747_3_0_1"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="393" mass="44150" checksum="15095A875103CC60" modified="2011-11-16" version="1">MSDIEYSIAGKQLKLNSAEDVEFIAKDLSDKSDIEKIDLSGNTIGIESSERISEILTKFQHSLKEINLSDIFTGRLNTEVPKCLDHLLPTLLKFPKLTTINLSDNALGLQTIEPIENYLAKAYTLEHLILSNNGMGPFSGERIGKALYKLSTLKKQKKYPSLKTFICGRNRLENGSMKYLALGLINHKDLQEVRLYQNGIRPIGIATLLSGLKQNQKLKVLDLQDNTLTSLGSSAIASNLGSWTALEELNLNDCLTKSKGFLHILTNLPLVKDLKVLKLQYNELDKTALTKLYELIDSGKVTVQKLEINGNKLEEDDELIEKFVELFEDKEIDDLDEMEGEDSDEEDEDDEEDDEEVEIIDFVALGKELDGTDEDKDEAVDDVAEELQKTHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B526</accession>
    <name>G3B526_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_134955</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B526"/>
    <dbReference type="GeneID" id="18249825"/>
    <dbReference type="KEGG" id="cten:18249825"/>
    <dbReference type="HOGENOM" id="CLU_474058_0_0_1"/>
    <dbReference type="OrthoDB" id="4017834at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="575" mass="66957" checksum="92C19437F4ABEF9D" modified="2011-11-16" version="1">MLLYSINQQLQGWRDINDTVKNQHPIHSVIVVPNNSLLLKYRDWASELISEIDKDCCPIKVDVSESGKEIIVRESLNIQFIESSKRFLNMSTNFSIDPLSPNFKPQIVIINSATFNKIFHNKKDIPGLPTKEAFADVKFVGIDEANFLFGASLASDMNPNIVVVGEKERLELYLHQSLKKLREIQYNTFKSRVEADTRCKFCPIQYCFMFHAQHPFHTSYVQMINGYKNLDKYNDPEAELVEKLTQMTNEEFALFRRELPLESVGELVRQHFYKKDENGNVVKRINLSLVDATRVPPKTRTLGYQSLKQFEDFPEREAFMDEFKVYAKEYNHQGNNVFKAYFKDKLMVDETRRSTINDAHFVHRSILQFRKTFPDSKDPILFVMRPTSHFPSMVRKMKSLLKASKKEPIELSCYHKPRNITSNQTHMADENEPYIDNPEDFKNFFIKNPTTNLLVPSDEFPGLDITGVKNIIICGSANWPTLATVSWNSSMSEAQKKLVSGIEMPHTDLFYYHLSKLQMENDQDDRNILWIQDSFYLKKSSITKRVIKQDSKSFREMLLYNDIISLVNHVPPHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B531</accession>
    <name>G3B531_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_98299</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B531"/>
    <dbReference type="STRING" id="590646.G3B531"/>
    <dbReference type="GeneID" id="18250757"/>
    <dbReference type="KEGG" id="cten:18250757"/>
    <dbReference type="eggNOG" id="ENOG502SBJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347134_0_0_1"/>
    <dbReference type="OrthoDB" id="3995760at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="672" mass="78529" checksum="032FB69F929BFDAE" modified="2011-11-16" version="1">MEKPRSSNSIGSISPGGSSSVLERQYAELLIKHNNMVIEFHQLEQELDIKNKTINDQLEQISNYERFLSHVKVEFGKTRDLMEKELVYYREMVEDYQLKFLKLNNELEYYKKLEFNQLESYSNDTDKDEKYNQLIKDFKILKSNFELEQNSKIMLLDQIESLSKENQKLKEDIMSSHSLNESSTNVNSETNQNFEYPTGSSIIHDLTYNYNTHTMNFNEDEETNNNSDDQFDNDFDYLENIEAQAQSSPIKEAFLFETPEESSSKDRVPSLIQTKDFQFPPSPDPTTKGKRQSLPANLQTEFILSPLKLASQDFDSAENQKRYSISRPNHNRYSSHDIVPIKVEFEAGVDQRSTSVPSPGRFNDIDERLEESKEIESTFKKLNGERNSYISSSKRSSLVFEANSRINNDLTKQEIMKLKFELQSLKLHNEKLMSYIGFELQKQKRNIKKLSSRQNLRDIEYSDSKLIERSREVLIQKKRVLRSVSINAILSKNYNNKDNLGILQKGILKFDDEALHENEYNEGEGEREDDDYGFMNFNDKFNKRIFATGLNNYYEMNDADNKNTNLKKFKSQNFFSNRNNFDISDVDITDTTLEDTIDDEIEWEDHKIPTNMNKGVFGQIRYLITGSYQLDKKAEVKESSVDDSLKYQFFSIAIGILIIGIRFGHYNHHNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3B558</accession>
    <name>G3B558_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_130666</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B558"/>
    <dbReference type="STRING" id="590646.G3B558"/>
    <dbReference type="GeneID" id="18249467"/>
    <dbReference type="KEGG" id="cten:18249467"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="46"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="449" mass="51193" checksum="4E8BC71A74A6DFD1" modified="2011-11-16" version="1">MEEVTFTTDRRTTQHTPLYYGTSLSPPNVSYHYNPEVTRYHYGPHHPMKPFRLLLTDHLVISYKLYEQMDLYTPRRATKDELLQFHSEDYVNFLESVTPQATGKLAEKTLAQFNIGEDCPVFDGMYDYSAIYAGASLDATRKLISGQSDIAINWSGGLHHAKKFEPSGFCYVNDIVLSIMNLLRVHPRVMYIDIDLHHGDGVQEAFYTSDRVMTVSFHKYNGEFFPGTGAMDERGIGRGKNYAINVPLKDGIDDDSYIRLFKSIMEPLITKFQPTAIVQQCGADSLGFDRLGCFNLNIRAHGECVKFIKSFGLPLLVLGGGGYTPRNVSRLWCYETSILNDVSLDDKIPNYLPTYDWFAPDYSLHPQLDGRIDNKNSKKYIECVKQEVLEQLRFLNHAPSVQMSDIPPDLTGLTEEEEDAIRDLNEEQETDREMRNVKDEARVGEMVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5C1</accession>
    <name>G3B5C1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_114501</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5C1"/>
    <dbReference type="STRING" id="590646.G3B5C1"/>
    <dbReference type="MEROPS" id="M01.034"/>
    <dbReference type="GeneID" id="18247450"/>
    <dbReference type="KEGG" id="cten:18247450"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014505_1_2_1"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="15">
        <location>
            <begin position="476"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="590"/>
            <end position="592"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV63182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="634" mass="72467" checksum="9BEF1B55EC6E54D8" modified="2011-11-16" version="1">MTGREAIQHKRPAISPELDPCTLSNYYDVNIVSSNLDLVVSFDNKTVSGSVTYVLKFASKRVSKLTLDCSYLDIKGVSVNDKSAPFTMLPISEPFGSPLEISLETIVDSEFSVSITYATTEKCTALQFINGDTGPYLFSQCQPIHARSLFPCFDTPGAKSPFKYKVYSPSKVLMSGLPEETIEKDVYYFNQPIPIPSYLVAIASGNIVSAPIGPRSSVYSEEPKIKECQWEFEQDMEDFIQVAEKLTFKYEWSKFDVLVLPSTFPYGGMENPNITFATPTLLCKDRSQVKVLAHELAHSWAGNLVTNCSWEHFWLNEGWTVYFERRILGAIAAIKAKRSGRQDYEEYGEKYRHFAAYLGWSELAQTIPDLAVESTSLIWNLTNQDPDDFYSRIPYDKGFTFLYYLENKLGGTKEFDDFIPFYFKKFRYQSIDSFQFIDSLYEFFVPKGKQEVLDSIDFEAWLFAPGLPEYQNFDTSMVDECTNLADKWISSFVKGDVDLIKATFDQEKDFASFDANQHLVFLGNLSKQLDSTDVDPLLVRVFPDVYPYYSESQNFEIIFNTSSLLIKYGSYSETDTTVQRFASWLHTVGRMKYVRPGYRLLAKHISRDFAIKTFEANDNYHPICKALVKKDLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5C2</accession>
    <name>G3B5C2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dopa 4,5-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_105930</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686977.1">
        <property type="nucleotide sequence ID" value="XM_006686914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5C2"/>
    <dbReference type="GeneID" id="18245854"/>
    <dbReference type="KEGG" id="cten:18245854"/>
    <dbReference type="eggNOG" id="ENOG502S1VD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090062_3_0_1"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19418" checksum="879999DE5D3BAC56" modified="2011-11-16" version="1">MDYLTKLNPEDPSSATKSTLGLSYEYPIKYYDFHVYYFAHNKKSLSESNFLRDKFLAEFTKEGKDGSVIVKKLPNDQIIGPHPTQFWEVDVCRPEIFIRVLSWFQLNHGSLSVLIHPQSGDDLLDHTNRALWLGDKLPLFTDVFDPFPSGIAEYGVKGGRRLTPEEFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5P5</accession>
    <name>G3B5P5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Family A G protein-coupled receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114570</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5P5"/>
    <dbReference type="STRING" id="590646.G3B5P5"/>
    <dbReference type="GeneID" id="18247482"/>
    <dbReference type="KEGG" id="cten:18247482"/>
    <dbReference type="eggNOG" id="ENOG502QZWT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054785_1_1_1"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="311" mass="34113" checksum="686238FA990CF82F" modified="2011-11-16" version="1">MASISEIVARGNQAIAINPPSSSVDIHLTSHGSDWLWAAFSVFATLALVHTGLFAATPSSTKSLKKFFTLVPLFTNAIFAYTYFTYASNLGWTSTPVEFHHVSTSEGLDVRQIFYVKFIGWFLGWPFVLLATEVATHSIEVKYDTSSELITKLFNIFSSLVAKVLTIEVFVLGLLIGALIHSSYKWGYFTFAVSAELFAISLIVNSIVRSLKTSETKKAGIAIVVFQLVIMVLYPICWGLSEGGNKIQPDSEAAFYGILDVINFGILPSALTFINTIGMDEGFLNKLLHLRSNEKVVETPRQSGETGETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3B602</accession>
    <name>G3B602_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B602"/>
    <dbReference type="HOGENOM" id="CLU_3014004_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="56" mass="6329" checksum="31DA4C5A65AE266E" modified="2011-11-16" version="1">MLARVHPPLIEQGSGRGRSPFDSQEGDSRAVNVNTYSFLNNDHRRVESVYKALNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B665</accession>
    <name>G3B665_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114707</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B665"/>
    <dbReference type="STRING" id="590646.G3B665"/>
    <dbReference type="HOGENOM" id="CLU_1120033_0_0_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="248" mass="29229" checksum="5CAA2BD6C85D5EBB" modified="2011-11-16" version="1">MDRLTLSQELCSSSWGQFDGDDDYTLLYVTSHQLENWSSIPKFQEDLRNKFTIRREVRRTLAIPPEVDPTGEENSDQENLDQEIQNEDSNENRNKRKREEPSENDQNQEPNPKKTPANALNVDFPEDEEDNEEDEEEIPEEETEDQPRYVRNKKILRKTIEKNPLFIQAALAPPVLISPVHNEEFREPKYGWMRQHQFAHGQGHPYWCAYDIVGSPQSTDKARVEEYGRKLQYKYLFILDVWLNMGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6G0</accession>
    <name>G3B6G0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114775</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6G0"/>
    <dbReference type="STRING" id="590646.G3B6G0"/>
    <dbReference type="GeneID" id="18247571"/>
    <dbReference type="KEGG" id="cten:18247571"/>
    <dbReference type="eggNOG" id="ENOG502QPQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030747_2_0_1"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="188"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="467" mass="53054" checksum="77E7B8D2E162E384" modified="2011-11-16" version="1">MSLLRSKIVQKPYQLFHYYFLSEQAPDSSLANLSFETDISITINKFKNHRWKRNEIAHYGFLSSVILFVFFIFPASFLIKLPILSVFGLCFLVPLTSQFFLHALPVFSWLALFFTCGKIPEEWKPAISVKFLPAMETILYGDNLSNVLATITTPTLDILAWLPYGLVHFVFPFVVAALIFVFGPPTALNSFGFAFGYLNLVGVLIQICLPAAAPWYKNLYGLQPANYSMSGSPGGLGRIDDILGFDMYTTAFSNSPMIFGAFPSLHSACAIMDVLFLSWLFPSLTVAWWGYGCWLWWSTMYLTHHYFFDLTSGALLSISVFTYTKYVHLPVMDRTKFCRWSYTEIPKVNINQMNPLTFNFNNDYVYNDLENQQPDILLSNPYQQSSSSSSGQPQSSLGIELENYSRSRQSSKVFLPQASGLPTIEDEETSSFDNSATTSVFDEVEQLSTIHFNTSLEDYDKRKPKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6N0</accession>
    <name>G3B6N0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_122581</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6N0"/>
    <dbReference type="STRING" id="590646.G3B6N0"/>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007105_4_0_1"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000013">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="151"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="792" mass="90625" checksum="92E227A718C8A6FA" modified="2011-11-16" version="1">METLEVHSKDFLIKWVNVPENSLVDWQIKPLKRSINFSIYRKRDVNESETSFLGDEKYRELNNSSSTSRSSTLSSNISNGDLVLVKNYNKLISDELVRGKLNVSRPGIYAFIFDNTFSKSTGKKIFHVSDEELSSEMIDTSKSSILRPKNGELLQGVLLKKRRKKLQGFVKRYFILNIKYSTLSYFRVNDNKLRGQMPINQSIISANSKKLEIIIDSGMEVWDLKATNKRDFDSWVNAFNKLKKHYYKEGEKNGATYHQEIIYEGDPKQNANYGSVLPTFLFEDLTSINSKLLNVINSNTQNTTLNTNLNSISDEITSLIQKLGTNRGSMNFDSMSLFSSNEFYDAKEYIDASNEGVVQFDDDDYYDDLDDDYFMEADETDSTNNVVEANDNDKDNNLYPLPLESVKRSLVIPEWNHPPSSLLSFLRKNVGKDLSSIAMPVDMNEPVTMLQKYAELIEYCDLINNALQVVDNQDTGEKILRIAAFAVSSISSVRDKERNVRKPFNPLLGETFELVREDKGIRLVSEKVCHRPPVFAAFVESKDWTLSWSLSPSQKFWGKTAEIINKGIIKLTIRSTGEVFQWSQPNSMLKNIIAGEKYSEPSSTITIKSSTGTKAVVEFTKGGMFSGRSEDLSIEAFGANKKKMPYSVFGKWTESLTLKTNTTEKLIWTSGKLVPNPKKRFGFTEFANDLVQITDIERDKMAPTDSRLRPDVAAYLNVDIDEAEKLKCELEENQRTRRKEMEQSGKTYRPVFFHHIGDTKAADSGEWVYNRGENSYWNRRSRQEWDGLLNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6R7</accession>
    <name>G3B6R7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_122657</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6R7"/>
    <dbReference type="STRING" id="590646.G3B6R7"/>
    <dbReference type="GeneID" id="18248916"/>
    <dbReference type="KEGG" id="cten:18248916"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_5_1_1"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="69"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="646" mass="71631" checksum="6B7209AE96269D41" modified="2011-11-16" version="1">MSSLVYFASKQLLKRALGDTLDDDLDDTPDVTTPDEGDDAENPVTEEIFSSWALFILLSLLCAALWSSYFLQQRRIKAIHETVLSIFYGMIVGLIIRVSPGHYIQDAVKFNSGYFFNILLPPIILNSGFELNQANFFSNIGTILTFAIPGTFISSLVLGIILYVWTAIGLDGVSLEFVDALAVGATLSATDPVTILSIFNAYKVDPKLYTIIFGESLLNDAISIVMFETCQKFHGKPVHFSSFFEGIGLFLMTFTISTIIGIFIGIMVALILKHSHIRRYPQIETCLVLLFAYVSYFFSNGAHMSGIVSLLFCGITLKHYAYYNMSRRTQIATKYIFQLLAQLSENFIFIYLGLSLFTEVELVFKPLLIIVTFLSICVARWAAVFPLSRLLNFLYKAKFKEFTNRNYVNGGISSQSVPDEISHSYQMMIFWAGLRGAVGVALAMGLQGEAKWALLATVLVVVVLTVILFGGSTASMLEILGIKTGVEQHLDSDDEFDIEAPRLPLSHNPTPSSSTQNVILGNRRFNEPFTRSQTSNHNLYKEENIRSRNDSNASLSRKTSNVSLSSATREDDDDDVPVSDNDDLLAGLEAGGPSSLNVASTNNSGVLSAFLSAEEHARWFTRFDEEVLKPVLLDTIPKRNNDSNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Z5</accession>
    <name>G3B6Z5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="10">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="10">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">4-hydroxybenzoate hexaprenyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="10">PHB:PPT</shortName>
            <shortName evidence="10">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COQ2</name>
        <name evidence="11" type="ORF">CANTEDRAFT_122773</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Mitochondrion inner membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
            <orientation evidence="2 10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="10"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686850.1">
        <property type="nucleotide sequence ID" value="XM_006686787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Z5"/>
    <dbReference type="STRING" id="590646.G3B6Z5"/>
    <dbReference type="GeneID" id="18248927"/>
    <dbReference type="KEGG" id="cten:18248927"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_0_2_1"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="370" mass="41522" checksum="CD1A4FB108AE7212" modified="2011-11-16" version="1">MFPGLLIKRAFHAPRTRLLSPLRSTWTQCQLVRHINLTSTPTPKPISDSGLDQVFTPEQREAARLARLANLGWLKKLPEKWIPYAELLRLEKPVGSLLLLIPSLWGITMASYAVQAPLTTFLYATSLFTVGALVMRGAGCVINDMLDKDLDRKVLRTTERPIASGRVSRGQAFTFLGVQMSLGLAVLLALPFECFYLGALSLPFISAYPLFKRFTYYPQIMISICFSWGALLGFPAVGAPLDLWVAGPLFASGFWWSMIYDSIYAHQDKAFDKEAGVKSTALKWQEKTRPIVNSLFVVQAACFAAAGVMNGMGLGFYTLGSYGFYRLFSKIKQTNLDDPASCWKFFTDNVKTGLFMWYGILIDYLWMLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B725</accession>
    <name>G3B725_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114390</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="3"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B725"/>
    <dbReference type="STRING" id="590646.G3B725"/>
    <dbReference type="GeneID" id="18247403"/>
    <dbReference type="KEGG" id="cten:18247403"/>
    <dbReference type="eggNOG" id="KOG4202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_1_0_1"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894:SF1">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="9">
        <location>
            <begin position="76"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="257" mass="28739" checksum="EB514E3F5A6EC12A" modified="2011-11-16" version="1">MKLVKICGIKRQQAASEAISFGADLLGMIMVPGRARTIDIEEAKAVAQLVKQTRQHKKRQFQTMTEILNVLREEDFETIDDYSDRISDLLEENGPFLVGVFRNQPMTDVFRISEEVGNDIIQLHGKENVLEYCSYNSKNFDSKFGVIPRFVIPNDVSKIYDTLEAICIGGKYFGNGFLLPLLDSELGGEGKLIDWSLLKELTSGKFILAGGLNEFNILQLSEYSNLKGFDVSGGVETQGEKDPRKVENFIKNGKSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B757</accession>
    <name>G3B757_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_106122</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B757"/>
    <dbReference type="GeneID" id="18245864"/>
    <dbReference type="KEGG" id="cten:18245864"/>
    <dbReference type="eggNOG" id="KOG0985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002136_0_0_1"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="8">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="539"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="688"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="835"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="981"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1130"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1425"/>
            <end position="1570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1665" mass="188844" checksum="170101F42C4C485C" modified="2011-11-16" version="1">MSSDIPIDFTELAQLTSVGIQPASLDFKSTTLESDRYVCVRETGASGNTVAIVDLYNNNEVTRKNMTADNAIMHPTEFVISLRANGTTIQIFNLGSKQRLKSYTMDEPVVFWKWLNNEYLGLITGSAVFYWNVFDGTNNGPIKLTERHHSLNNAQIINIVAEPDLNWFAINGIAQEDGRIAGHIQLFSKTRNVSQAIEGHVSKFASIKLSGAAHPTKVFCVGNKNAQGQGNLHIIEIDHVDGNPPFPKKSVDIFFPPDATNDFPISLQASDKYGIVYILTKYGFIHLYDMETGSNLFVNRITADPVFTASAFKDGTGIITINKAGQVLSVEVSRDRIVPYVLDKLSNVSLALSLSSRGGFPGAENLFTQQFQNYLNQGDYTNAAKVAASSEQLRTPDTINKLKHITPAPGQISPILQYFSTLLDRGTLNKYESIELAKPVLQQDRKPLFEKWLKEDKLTSSEELGDIVKSYNDTTLALAVYIRANVHIKVVSSLAELGQFDKIMPYCQKVGYSPDYTNLIQNLVRVNPDKASEFATSLLQTPDSNINVENVADLFFSQNYIQQGTAFLLDALKNDSPAEGHLQTKVLEINLLHAPQVADAILGNNMFSHYDKPSIGKLCEKSGLFQRALEHYDDLKDIKRVIVHTNVLPNDWLVAYFGQLTVEQTVACIKELLSNNMQQNLQVIIQVATKYSDLIGPLNLIKIFETYKCTEGEYYYLSSIVNLTQEPDVVFKYIQCAARMNQPKEIERVVRDNNVYNGEKVKNFLKEFKLDDQLPLIIVCDRFNFVHDLILYLYKNQYFKFIEVYVQQVNSANTPQVVAGLLDVDCDETIIKNLLNSVIGRVPIKELVVEVEKRNRLKILLPFLEATLQGGSNDQEVYNTLAKIYIDSNNSPEKFLQENSNYDTLVVGKYCEKRDPYLAYISYSKGGNDDELINITNENKMYKYQARYLLAKSDFDLWNKVLGDDNIHRRQLIDQVISTGIPELDDPEPISLTVKAFMENDLPQELIELLEKIILEPSPFNDNTSLQGLLILTAIKADPSRVMNYIEKLDKYDPQEIAPLCIDAQLYEEAFEIYDRFELRTDAMRVLVEDIMSLDRGEQYAEKFNTSELWYQLGTAQLNGLRIPEAIESYVKSKNPENFEQVIEISERAGKEEELVPFLDMARETLREPLIDGALINCYASLGRLSEIESFVSGPNVADSESIGDKLFEAKNYKGAKILYSNVSKYSKLATTLVYLEDYQGAVECARKASNINVWKQVNNACIENKEFRLAQICGLNLIIDAEELPELVKTYEWNGYFNELISLFENGLSLERAHMGMFTELAILYSKYSPEKVMEHLKLFWSRINIPKVLTACEEAHLYPELIFLYCHYEEWDNAALTMIEKSEVAFDHLSFKEIIVKAPNLEIYYKAINFYLAENPSLLVDLLSVLAPKLDLPRVVRMFVKSDNLPLIKPFLISVLEKNNSVVNGAYHDLLIEEDDYKSLKEAIENDAYNRFNSLDLAERLENHEIIFFRQISATLYTKNKKFTKSISILKNDKLWPDLIKTAAVSNSTKIAHELLDYFVETGNHECFVALLYTCYDLIEYDYVIELTWLHNLANFVKPYEISVAAENQKLLNEVYADLKKRREAEQQDEDAPINQPLMITNGNAGMAGIGFQPTGAGFGNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B798</accession>
    <name>G3B798_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115062</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B798"/>
    <dbReference type="HOGENOM" id="CLU_1981367_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="126" mass="13447" checksum="F327EC303E5F6E6A" modified="2011-11-16" version="1">MPNDPPPYRESEGNKSSPQPSEPEKAVPSVKPKPKALSSASTVSQTSLESELEATLAKRFAPLSVKSEASSVASEEVSMKPSSNLESPTKPKPLLKPKPQLTPKPQLVPKPDTDGALPPPAPRRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7F9</accession>
    <name>G3B7F9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_115726</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7F9"/>
    <dbReference type="STRING" id="590646.G3B7F9"/>
    <dbReference type="GeneID" id="18247987"/>
    <dbReference type="KEGG" id="cten:18247987"/>
    <dbReference type="eggNOG" id="KOG0861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074848_0_1_1"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000020">
        <property type="entry name" value="Synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13774">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
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        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="12">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV62267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="200" mass="22894" checksum="8178F16C3A299211" modified="2011-11-16" version="1">MKLYYIGIIKTSGSKAVELAHAKDLSQFSFFEKNGVSQFMTFFAETVSQRTQSGQRQSVEEGNYIGHTYARSEGLACVIISDKEYPVRPAYSLINKVLEEYLSLHPKSEWENLEETNNTLNYAELESYLKKYQDPTQADSIMRVQQELDETKIVLHKTIENVLQRGEKLDSLVDKSEALSSSSRMFYKQAKKTNSCCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7J0</accession>
    <name>G3B7J0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94512</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687798.1">
        <property type="nucleotide sequence ID" value="XM_006687735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7J0"/>
    <dbReference type="STRING" id="590646.G3B7J0"/>
    <dbReference type="GeneID" id="18250406"/>
    <dbReference type="KEGG" id="cten:18250406"/>
    <dbReference type="eggNOG" id="ENOG502S5BH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030508_0_0_1"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442756" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33747" checksum="1DD104FB1AE1B50F" modified="2011-11-16" version="1">MLPQFAITALLFATSLAAPIEAPLNFRVITSNVRVKTNKPFAHEQPWDVRKYGQIQTLQQQSANSSTLIGLQEIKKDMLDEVIAGLNNNQTNITSGWTYFGVGRDDGVEKGEYAAVVYDNRVWDLVNGTYKWLSPTPDIPTKGWGASNIRIVTMTELKHIQTGKHINYFNTHYDQTSEEAREHSSELIAGWISQIPNDYQTILTGDFNSIDTDLSYTTLVKDLADTRVIAYQKYSQEPTYTGFEPTDNQTVIDFIWAPIDSNTQGSNTTVIDYNVIDNVTPEGYRFSDHRPVVVDFLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7M3</accession>
    <name>G3B7M3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_115107</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7M3"/>
    <dbReference type="STRING" id="590646.G3B7M3"/>
    <dbReference type="GeneID" id="18247721"/>
    <dbReference type="KEGG" id="cten:18247721"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609704_0_0_1"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="449" mass="50566" checksum="2C7E00150BF763D2" modified="2011-11-16" version="1">MEDLDFNDTKMNYNLHPISYLNANANQYRNQENSLNSNNLNIHNSLPIPITLKQEPESASHSANSSRQDSLSVSTYDSLSLTPHSSVSVHDSPSQSFASTSISPPSGPDPGTAANPAKRKKTYKKIKAEDLKGPFRCLWNQCTNVYDTPEILYDHLCDDHVGRKSSNNLSLTCYWDNCLTKTIKRDHITSHLRVHVPLKPFHCELCPKSFKRPQDLKKHSKTHTQDHTQAKKLNKQLKQQSKSNNVSIINNILSEFNFDKASFFKKEPTYNSEMMHRLNNVEGQAFAAPQAPSVNSLYDAEKYFSTLNQSMDSFHQTFSYPQNTINNNHSSGHTQPQYQAQAQPQFHTPSVQSAQGAFGSYPSMANNYPRNNQFNYPVSSDFGGVSNFQKSSRVDADSQVDDVDALAIDLEKVSVSDLEKHKTMVKGVLSYLHEKMATSCNLYPQITAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7T5</accession>
    <name>G3B7T5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTEDRAFT_107829</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7T5"/>
    <dbReference type="STRING" id="590646.G3B7T5"/>
    <dbReference type="GeneID" id="18245984"/>
    <dbReference type="KEGG" id="cten:18245984"/>
    <dbReference type="eggNOG" id="KOG0666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="33"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV62317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="426" mass="49205" checksum="FA5F073B2C1805AB" modified="2011-11-16" version="1">MNSSTLMASNSILTLGPYKHRKDLTRESVLSKYEIVGYIAAGTYGKVYKARSKLKDKRKPEDDNLVEQPVQQLFAIKKFKIDNNSLSKNSHLTIDGQEVLNYTGISQSAIREMSLCKEITNKNVIKLIDIILENKSIYMIFEYCEHDLLQIIHNHSHPELKPIPLKNVKSLIWQILNGVLFLHKNWIFHRDLKPANIMVTNYGTVKIGDLGLARKFNNPLQSLYTGDKVVVTIWYRAPELLMGARYYTPAIDLWAVGCILAELLSLRPIFKGEEAKFDINNKKSVPFQKNQFLKIIEILGVPNEKDWSNLSNYPEYYSFKQMAESYTGNTNSNLLNWYKLVGGNNKLCYKLLESLLLYDPSKRITAENALMHEFFMEAPKVDENAFDGLQFKYPKRRIFTEDNDIVSNNITKRVTNDDGMRKKIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8L8</accession>
    <name>G3B8L8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115213</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NSA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8L8"/>
    <dbReference type="STRING" id="590646.G3B8L8"/>
    <dbReference type="eggNOG" id="KOG3881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22858">
        <property type="entry name" value="Nsa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="400" mass="45150" checksum="470567647976BA1B" modified="2011-11-16" version="1">MKVLVSSDETGHVKEVVCLKGTDTSKKDGVKPISVSKVCLEPAASLKSRVLHMIIFEDYLITLRIDGVVCIYTLSDYTLVKYIKLTSVKPVSLINYSQFGCFIAAFENNKVFIMTVEDEPVELNLPVEDKNPTIIATFAPNPFKDGEFAFGGEENDIKLVSLFEKPNKKFMSTKFEPKIVFTAENVPNDFLDLRVPISVKHIKFLEENKFISVTKYGQLRIYDTTIKNQPIHDFKIGPKPIIQVAISEDNAILSDTTSLIGKYSLTKIDSNATRINSASAGELRRPSVKLLGKFNEGTNTGATHAIYNFENKYVATGGLDRYLRVFDIKTRKLVAKVYLGTQISSIIVVEDDEEEEVVKKSKKRHDSDNDEDDEEDMWTQLETNTKEPEPKKLKKKSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8V6</accession>
    <name>G3B8V6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115229</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8V6"/>
    <dbReference type="HOGENOM" id="CLU_1895930_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="134" mass="15260" checksum="53323D388D19F03F" modified="2011-11-16" version="1">MSKLECSVDCTPNGCKVTLPSNSTNSSTLNLDFDNGNEVKIWFNEPMLYSQKEKSLTFEYTLDCTPDGCKLSSSTNSTKWDFDFDDGKEVIFSFNQPFLYYQKQKEKVTSGSSSTFMNNKCSIVLFLLMTSMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8X2</accession>
    <name>G3B8X2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_135735</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8X2"/>
    <dbReference type="STRING" id="590646.G3B8X2"/>
    <dbReference type="GeneID" id="18249904"/>
    <dbReference type="KEGG" id="cten:18249904"/>
    <dbReference type="eggNOG" id="ENOG502RZAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028201_0_0_1"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="184"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="464" mass="52693" checksum="17C66925EC1BBDC1" modified="2011-11-16" version="1">MNVGSILNDDNPSDTEVSRPTSAIPKSVQSAEPPRQRNSIVSLLNDDKTPTPEKESSSSSLRQEIKEEPQLTQAGDSESRSVFKTSESATKPSPPANGHVKSEEQEEDEIKKLTKLKGKTKPKRYKTPPIWAQEWTTKSSNNSAARNPEESMDSLSLSEKSIFNTSTTSSVDLECSITGIIPPPSVTRRIAEWIYANFIEINEANRKYVELELKFGTIMDKVSRNRIAISVSTECIYTDASSIFFESGIHQVGFEDMLKFLEELEKTYQEDLKSQPPGKPRRKFNILETDVTDSIYYTRGRNEQPKSVRISKDNLLNPPRYTAINKQRISDLYIHNPSSMYDLRLSLSLENPVPNEEIESIMKKSKPSKVRIKQRNTFTHRPTITQFDFTRVTSPKESKNTQTGKRVIDNEKSYEVELEIDVAELFAGFDMFKSGTNAIRFEELVEVFINNARSLNNRVTKLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B922</accession>
    <name>G3B922_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_109386</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B922"/>
    <dbReference type="STRING" id="590646.G3B922"/>
    <dbReference type="GeneID" id="18246106"/>
    <dbReference type="KEGG" id="cten:18246106"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_4_3_1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GH16" evidence="9">
        <location>
            <begin position="17"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="463" mass="52376" checksum="27EB04FF38E055F9" modified="2011-11-16" version="1">MVIIIFGSIGYGIHVAKEWWSPLPPEVYEVLSPYIYPPLSAIRTSLVDPDTPKDAHQRKSFQTGEMWDLVFSDEFNADGRTFFEGDDQFFNAVDIHYAATNDLEYYIPDMVETSNGSLRITLDAFPINGLDYRSAMLQSWNQLCFSSNAIVEVSLRMPGYSQESGLWPAVWSLGNLARPSFQATTDGVWPYSYDECDHGITPNQSSPDGISFLPGQRLSKCTCLGEDHPNVGVGRGAPEIDIIEGFHNAFDKKGVGVQTLQVAPFDSWWRPDYDYMMIENPNITSLKPDTGTPTQEAIAAGTIMNENWYVNHQNTTDPDRHTYFQKFGFEYSSAKTAETDSYIQFFAANSPTMSIRGDALHPTNNIGWRQITKEPMSLVFNLGLSETWSTVDFGSLKFPAVFEIDYVRIYQQKNDTSITCDPYGFPTSEYIYQHLNAYRNFNLTSWKQAGYKSPKNSLMHGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9D5</accession>
    <name>G3B9D5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 4E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF-4F 25 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">mRNA cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115945</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9D5"/>
    <dbReference type="STRING" id="590646.G3B9D5"/>
    <dbReference type="GeneID" id="18248093"/>
    <dbReference type="KEGG" id="cten:18248093"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_2_2_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="210" mass="24329" checksum="B036D648ECBF87FB" modified="2011-11-16" version="1">MSEELATQTEALSLENKETILTTKEDFTAKHPLNNKWTLWYTKPQVNKSENWHDLLKPVITFSSVEEFWGIYNSIPPANQLPMKSDYHLFKEGIKPEWEDEQNAKGGKWQYSFGNRREINATINDLWLRGLLSIIGETIEDDEDEVNGIVLNIRKQVIKIGIWTKDCDETKLKTVGERLKKVLKLAEEQRVEFTSHDASNDKNAKPQIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9Q5</accession>
    <name>G3B9Q5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_109620</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9Q5"/>
    <dbReference type="GeneID" id="18246128"/>
    <dbReference type="KEGG" id="cten:18246128"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011220_1_1_1"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="197"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="420" mass="48694" checksum="7E7594EF84C43A36" modified="2011-11-16" version="1">MNGNTDRTPLLSSNINENPYKHIDNAHEGINDNINDSTIRQEGKIDKKSRSNASSKIGLQRTSRTSQKMKLLPEEPLLKDASSKRSVTSESNKIYTQVERITDVPARKDAETLGKVHRDLLPRVTAYCTSGSYRMKDLMRWLKDRKRIHNTNVKLFDDVLYTPFTYKDWRSETDDQDKTIRLADEGGEIDFGKRNEIFIFEYGVVVMWGYSIREEQSFLIDISNFENEKLSNEDIQVEEFNYYITKSYQPRIYNDFITISDDSNYMLKLSISHAISQSVKISLFEELVNNTIEDTQDIPQQIATTGKVEMNRNEIMKSIGELFILRININLHGSVLDSPELMWVEPQLEPIYQAVRGYLEINERVELLNQRLEVISDLLQMLKEQLGQTHEKNLEYIVIILVGIEVLVSAINIIVDLFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA08</accession>
    <name>G3BA08_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_94868</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA08"/>
    <dbReference type="STRING" id="590646.G3BA08"/>
    <dbReference type="GeneID" id="18250446"/>
    <dbReference type="KEGG" id="cten:18250446"/>
    <dbReference type="eggNOG" id="KOG2376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013808_4_0_1"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="550"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="596"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="655" mass="73932" checksum="E2F9585CC151F9CA" modified="2011-11-16" version="1">MSTSIAQAFKKLNVSSVSEDHVNIFEVSYQYLSNVKKFNDVKSFNNCLVALINLDKYDKALELIKKVKSEELIQQFSIEVGYIYYKTKQSQLLQELYQRILSRDSTSKFMIRGLKHIVAQDYYQKGEDKQALELYQDLIKENDEIDNSLDLYTNELAIISQLNFSSHELKEPLSSTDEQNHDLVFNQALISLSENKATLALSQLDKALELLGYLKLDDESYQIEKCPIVLFKAYIYQTEGQKEEALKLLEDLKLNKFNDIMINLIINNNYYAINEVLVDQTGSDRNVNLAQRVLNYQQNLAITARKLNHGQYTTLIQNNILLKYLTNSLTVKSNQLSSFNLSKLVSKGNFSLLSFKVLIKLGITNEDLISSPRVVSKKLFKAINKSEITEANFNELVACALILLSIDSVSGNYNRSVISLEKLTEFNFKQLSKLLPGLIGSLVNLYETVDATEKLNKLYNTLIQTLDNASSLSHVDFNFFKVIGFKLLIVNDERYNTVFTKLNQANSEDVLIKNVLHNSSEHLLPVETLVSSVDDDIVNTDIDSLIPVSQVSKSSSSSSKVEKKRTKKARFGPSKVLKPADQINLDQERWLPLKLRSNYKPKKSKKKVSTHQGAIESAGASQVSTPSSTPAPTMSNESSAGSSKKANKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA49</accession>
    <name>G3BA49_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_125448</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA49"/>
    <dbReference type="STRING" id="590646.G3BA49"/>
    <dbReference type="eggNOG" id="KOG2066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001285_2_1_1"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000933">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="7">
        <location>
            <begin position="103"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="5">
        <location>
            <begin position="688"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="980" mass="112404" checksum="A9D0825147D07123" modified="2011-11-16" version="1">MEANTEDVDEQQGQDPIEEANRNFHSTKDTAVSINEPVSTYTSHLEEAPETDDDNDTVGNTTFETTYGSDEDDSNDVPGEADIQRTEEIDAYSIDEEDEPPKLKYSRITGLPPNFFSRDPVSCCNIHDDYYIFATHSGIIHVTDPNFTTIRTFKAHRASILSIYTDGQFFASGSMDGTIVIGSIKDEKDIIAYDFKRPIHAVVLDPNYSRTRSFVSGGMAGKVIHSSKNWLGQRSDIVLDENNGPIVAIHSVDDILLWMNDKGISIFHTQARQVIKVIDKPEDSPRSDLYWPRVHSLEMDRVLIGWANYIWCIRVSIRTSEDKSEMASNKSRILPSAATISFRAVQEKKVEIEHVFKLDSLIAGISSFTDDYWMILSYEPPTADGDEKVKFNYPDLKLINSLNGEVDFEEEIGMKNIDNLGLNDYSLHRHIGSDSTSYFVVSAKDGIIAQEVQLNDRLDWYISHDRYRDAWEISEHLLSPEKRLNLGLKHVDNLVRDDGWELASQLLAEYFSSSMSYDEDFVKNVVSQWESWSSIFIQANHIKELTEVIPRSPKFSLSASIYDSILSYWIGKNVSKTVELISEWDVELYDSKKVESLMETSLEGSESSILRKCLADLYVKTYKPQKAVEHLMKLKDPNLFMFLADNHLLTNFLSDIPQIIKLKFSDDEYNNLPLKILENKLRDVIQVLVDHRHELNTRLIFNLMEQQHLTFINYLYLEKLNDIDDFLLSSFGDERVKLYSEFDRPKLLPFLMRSSDYDIDLAISICESSDFIEELVYLLGKIGENKKALTLIIDKLNDPEVAINFAKHQNDREAWNILLDESMTRPAFIKALIETADDQSNPFYDPISILKRIPNNVKIEGLKNSVSKINENNELNYLMNQLILKLIYGRSEAISKGYRRNLLKGYEIETNDAIFKELIGKFQTILFYNDSLDSNPVFKSQSEMFPQGMAVTAYTNLDKKLEHLQFLTNYLKSKSANDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAB6</accession>
    <name>G3BAB6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114882</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688687.1">
        <property type="nucleotide sequence ID" value="XM_006688624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAB6"/>
    <dbReference type="STRING" id="590646.G3BAB6"/>
    <dbReference type="GeneID" id="18247619"/>
    <dbReference type="KEGG" id="cten:18247619"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049057_2_1_1"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="105"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="259" mass="29285" checksum="8BA45674DCE4AC01" modified="2011-11-16" version="1">MSSIFRLGARTVGGSVFRTFTQSSYRAAAPLAVRFKSSPAATTPSLTAQIFPMDKDTITEKDVDEWIQSLQRLKNGHTPDNATEIYIDELTRPEEYLKQQFEASEQQLQEQQTFETARIPLASIPVVDNVVNLIMRNGKKSQARKIVARALYLIYLKMRVDPVIVLEETLEKLGPLTNTKVVKTGHAKNIIRPYPLNERQRRRYAILWILDGAAKKKSSDYSVRLAEEIMSAHAGKSSGYEKKASMHKVSIAQRAYINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAX8</accession>
    <name>G3BAX8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCS3</name>
        <name evidence="8" type="synonym">FIT2B</name>
        <name evidence="11" type="ORF">CANTEDRAFT_114941</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAX8"/>
    <dbReference type="STRING" id="590646.G3BAX8"/>
    <dbReference type="eggNOG" id="KOG3750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442891" description="Acyl-coenzyme A diphosphatase SCS3" evidence="10">
        <location>
            <begin position="20"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="336" mass="38850" checksum="AA5C16DDE55BBA5C" modified="2011-11-16" version="1">MVLFLYVLVVPFSFAASSATSQVALISQIRIANCSDMNADKYKHHEKQLASLAHRIRHKYKVSIGELTFLASFLVNFVVGKLIHFTSQKEEVYNYYNDKNNVFNQLFVKRGWFWTTVVMAAFYGSVFYGKHPQLGTNRFPVAKNAIISYTIATAWWILFTQWCFGVPIMDKIFLWTGGRCVSVAEDRLAHHSEFFNKVEDLYESTVVGSKVCRQLRGNWEGGHDPSGHVFLLIHSSLYMFFETVPFWRNWTHVRTTLGKLKQDLSVSDNRTITVGRFFLHNPWIPVGMLILLWWFMLLMTNVYFHSILEKLVGLLFGYAISLVYLLPRRRATTGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB92</accession>
    <name>G3BB92_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">CANTEDRAFT_124295</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687689.1">
        <property type="nucleotide sequence ID" value="XM_006687626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB92"/>
    <dbReference type="STRING" id="590646.G3BB92"/>
    <dbReference type="GeneID" id="18249017"/>
    <dbReference type="KEGG" id="cten:18249017"/>
    <dbReference type="eggNOG" id="KOG1784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_8_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="98" mass="11112" checksum="664D7E2974D239F9" modified="2011-11-16" version="1">MSSWKEFLYKKVRVITTDARLFEGKLEGIDNATNIVISNCIERIARVKGTDDKYQQLDMGLYMLRGGTVVCIGEVDESIPVDWENLTGDKLKDTKNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBH4</accession>
    <name>G3BBH4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_95083</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBH4"/>
    <dbReference type="eggNOG" id="ENOG502RQCT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1805924_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="143" mass="17180" checksum="FA9B0384FF7979DD" modified="2011-11-16" version="1">MTFQYINVIDESFDTTLDWDQLDAIVVQNRIRMSRNRSVRLPSQLWVSTMPLPNYSPPPQEKFHLLGESLNRPVPVKPMLPPFATNTQMCNYVHKKYIYSQHLMEQLQRQNSYHNKYVESLRRTKLKHHHDTELSRRLSRRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBX6</accession>
    <name>G3BBX6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_126985</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FYV10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBX6"/>
    <dbReference type="STRING" id="590646.G3BBX6"/>
    <dbReference type="GeneID" id="18249207"/>
    <dbReference type="KEGG" id="cten:18249207"/>
    <dbReference type="eggNOG" id="KOG0396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027445_2_0_1"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="8">
        <location>
            <begin position="227"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="432"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="432"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="509" mass="58556" checksum="58840BAA6A176B2A" modified="2011-11-16" version="1">MSEPTLNFHVQAGSTQFKVPTELIRKNFKTIQKLIEKQKRQAANDIANIKKNPSLPTAIKLEMIRKIIRSFEALEKKLKASINKDQEYRSRLLARLENLQELTKFTVTRNHDQDITIDMEDNEHAIADDLEDEDPKSVKTKARKSMSGDEDKALDLHNPTLINWYRDQANLLIIDYLIKSNVSSEQSVGLKLLQSLSVSNPKYMKLIDYDLYETLNKVFLSIVEHHDLSLVIAWFEENRTALKKANSNIEFEINYCKFLSFIEEGRTDEAIKFSQVHLSPSGNINNYQENEHDSYLNNLKKLKEIGGLLVYLAINEHSSPSQPVGSFSTSMVKHSARFHDYEKLLSDDRWIFLSECFMENFTKLYGISRNFPLFIYLSAGLSSLKTKSCYCNNDNTIFVNHKQPHEEVGSLKDRKYRGPNHYYKRLNRINNCPVCSPELFKLSRNLPYAQLITSIFNNPYKLPNGNIYPIDKLTTPSSLKNSGSGSSIIEDPLTKEVFALSECVRVYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC11</accession>
    <name>G3BC11_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial group I intron splicing factor CCM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116822</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC11"/>
    <dbReference type="STRING" id="590646.G3BC11"/>
    <dbReference type="eggNOG" id="ENOG502S1M2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013751_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="76118" checksum="19BFE7F852DA5E26" modified="2011-11-16" version="1">METFDTIAKACASNDIPLYDEFFQSYMNYVEKMFEKDHPQVHEYKQLERNIFRIQQFTSDLTRQLDFEKRTRSTILRFLGFTNELISVNYNENLISSRRTILDYLQSIGSKLTGTFLRQAPGDESLFDHTLDALLSEGYQELPVVLLNSVLENQMFYSTERIVQAKAYLLPNQDEHQLFESVEDILQQDSSGVDASKVYLKLIHIFVTSGRVSPNGVFVTELTTKFNNEGIETPLEAYKICIDAAIKNNDMATSSTIFEQSINSYVQWWDGTGPKVLRTLNDLIILACKNMNDIEDLFLFFSKIKQQMTDRPINIYAITELSRRMLQVEYVGDCIEMLKRELPSIKKDDNIKIEVSQPYAAAYRQLFDLLHEFAISYTNEETFETNWVLYGELHKFFHVPYESYFPAIKFFSERGRLNASLIIFRQIRNLYETHGNHNNLPPSKEMYVYLFEEFGDKLYQEGVEEIHEYLKTDVSLPRQDLELQNSLLQAYSNLQEVGKTRDLFLAMNPMKKIEGKSTINEETVQIMLKTFTYSNLNHVKLFWNNLSRFGILPNDAIFRQYLIAYVYHGFPEEATSLTEEMDDYGLEVTEDTVVSLYNFCLSSEDQDKIEEWAHAHYKELWQSAVDKKLLTRSNNYLPESSLLLENVTAAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCD0</accession>
    <name>G3BCD0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_128442</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690022.1">
        <property type="nucleotide sequence ID" value="XM_006689959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCD0"/>
    <dbReference type="STRING" id="590646.G3BCD0"/>
    <dbReference type="GeneID" id="18249306"/>
    <dbReference type="KEGG" id="cten:18249306"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009031_2_2_1"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="319"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="722"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="350"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="754" mass="86020" checksum="A1E85491818AC0F1" modified="2011-11-16" version="1">MYKIPFWPGDTLYTSQALDKPSCKPLYDETNDYINEDHIHEFAKALVWDSEEDLGENDISLRNQMDALGAVDGGDMAAGLSPTRRSSKPDLIVSKSDWYPVHTPMAASDSNTKEPRSKRASKSNDSKHATNEFRASAGYLLLRWPILIGVLMWMGFLGGCYSAVRFWVALSEYYFTWTGDRKRLRDRLRASKTYEEWVANALALDRFLNLDKWSSNPKFSYYDYKTLRLTINKLRQLKNANMDSELLIMLQGCVKTNFAGIENRQLYSHRYYGTKNLVEDYIQLVTECIDHITDSESIPFATKRKFFRFISKNYGKTALCLSGGACFAYTHFGVIKALLDNNLLPSIVSGTSGGGVVAALACTRTDEELKKLLVPELARKITACEDPWWVWVPRFWRTGARFDSIAWARKCNFFTKGSMTFQEAFKYTGRKLNVSTVPADPHSPVILCNNITSPNCIIWSALLASSAVPGILNPVVLMMKNPDNGRVVPFSLGNKWRDGSLRTDIPIDALNTYYNVNFSVVSQVNPHISLFFYAPKGTVGRPVALPRRYTNRQKYASFRGGFLGAAVEQLLRLEITKWLKIIKNLDLLPHLLEQDWSNIWLQRFSGTITVWPRNRISDFLYILSDPTVERLEEMLMKGQRSMFPRLLFIRHRMTIERAIERGRKATRLGNKYETSHVMSSAGTVNDTEVHGVRYHGDDDETGSSEEDVTMLESPFARQFGWEEQVSASSRTASPEVTEDELEEPREPKRRYTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCI0</accession>
    <name>G3BCI0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAP42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116231</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCI0"/>
    <dbReference type="STRING" id="590646.G3BCI0"/>
    <dbReference type="GeneID" id="18248208"/>
    <dbReference type="KEGG" id="cten:18248208"/>
    <dbReference type="eggNOG" id="KOG2830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041824_2_0_1"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="39448" checksum="E5390AF90BD27795" modified="2011-11-16" version="1">MSNGPNEQATVGERYEHLISKFTALEAKPIPKNSKEYQTQLYSLIKQFKFIDKIIADLDLFSDNEFIEEINVNYLPFLNVNYYLGELFLNFMVDANLELSIDFKADNLKISSEYFNLYLQRLIELELLNPLQTKQLKGYSLNREEKIQQYRYQKELEGKLALVHTTEDEDIKRQLYLDHINLLTIRALHHLQMIEMEIQVLSNRPSSIEEISAPIQPNNEDRRKQTADDYTTRLETLPQNQPIQNLLSKGRVLQPFTLTRQDLKNKVFGTGQVLPSMTVEEYLDYELANGKMAQPEEPPANSDDEDEDNEDEEYRKREWDDWKDANPKGIGNTMNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD71</accession>
    <name>G3BD71_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_111025</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD71"/>
    <dbReference type="STRING" id="590646.G3BD71"/>
    <dbReference type="GeneID" id="18246245"/>
    <dbReference type="KEGG" id="cten:18246245"/>
    <dbReference type="eggNOG" id="KOG1268">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_1"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="372"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="544"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="696" mass="77122" checksum="1C8E9242F916C13E" modified="2011-11-16" version="1">MCGIFGYVNFLVDKTRGEIVDTLIDGLQKLEYRGYDSAGIAIDGDKKGETLIVKTAGKVKALKDKLDNSNIERSTIFDSHVGIAHTRWATHGQPMESNCHPHRSDPEAEFVVVHNGIITNYRELKTLLVSKGYKFESETDTECIAKLFKHIYDTNLKANIEVDFNELVKQVLYELEGSYGLLVKSSHYPGEAVGTRKGSPLLVGVKTEKKLKVDFVDVEFPEQNQEVPVGSAKNGELNGFIPLSGAEASLRTSQSRAFLADDGLPMPAEFFFSSDPASVVQHTKKVLYLEDDDIAHVYDGELHIHRAKKNAGDSTTRPIQTLEMELNEIMKGPYTHFMQKEIFEQPDSTFNTMRGRIDFENHQINLGGLKAFLPAIRRSRRIIMIACGTSYHSCLATRSIFEELNEIPVTVELASDFLDRRSPVFRDDTCVFVSQSGETADSILALQYCLERGALSVGIVNSVGSSMSRQTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSNDSISQQQRHREIIDGLQKIPEQIKTVLKLENKIKTLCTEHLNDQRSLLLLGRGYQFATALEGALKIKEISYMHSEGVLAGELKHGVLALVDDKLPIIAFATRDSLFPKVLNAINQVVSRDGRPIVICDEGDTVLSSSQTTATLHVPTTVDCLQGLLNVIPLQLMSYWLAVNRGIDVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD91</accession>
    <name>G3BD91_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116331</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689485.1">
        <property type="nucleotide sequence ID" value="XM_006689422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD91"/>
    <dbReference type="STRING" id="590646.G3BD91"/>
    <dbReference type="GeneID" id="18248252"/>
    <dbReference type="KEGG" id="cten:18248252"/>
    <dbReference type="eggNOG" id="KOG2940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046586_0_0_1"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="346" mass="38680" checksum="86371792E67ECF54" modified="2011-11-16" version="1">MLRRTLATNAPNHQFNVFDRVAKLAQRSRFPKINPQESKKVEYLRDEVATKTIERLAFITRDLTNTLDFGSNGGNLLKNLCIPTVIPPDASTEMSQHLTQLNKDKLTIRNRISNYTMFDSSQEILHRDVHESYWDAFAGTTDRVVGDEEKFNHPVLKSDYFDSVISNLSLHWINDLPGTLANINRVLKPDGLFLGTLFGGDTLYELRTALQLAELERKGGLSPRVSPLVELNDVGTLLNRAGFNMLTIDTEEIVVGGFPDIVSVCNDLQLMGEQNAVLSRSGYLDRDLLLAANEIYKALHGEKGPDGTVTLPVTFSVIFMIGWKKSENQPQPLPRGSGQVNLKDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDW0</accession>
    <name>G3BDW0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_110897</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDW0"/>
    <dbReference type="STRING" id="590646.G3BDW0"/>
    <dbReference type="eggNOG" id="KOG0831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023995_4_2_1"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV60396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="463" mass="53295" checksum="9585093F24AF43CB" modified="2011-11-16" version="1">MSLRQRNVPSGEKSTSSATPISLPSTPISSSSTESSETKSKSELYFNRNRKSKRYLNIAPLNIPMSRRLETIGIIWHTVSIPFFFTLCLFLVYLGWVSWLLIILPYFIWWYGFDLHTPTNGKANYRVRNWVKNLIVWEWFVNYFPIRVHKSCEFEPTFSEVVEDEDNLDDDDEEDLINENSTTIRLNKVDNVKYRTVSNGPRYVFGYHPHGVISMGVMGLFATNILRNEAFEPPARFLRFLFYDPSKHKPLLPNIGNIFPLTLNTQFTLPFYRDYLLSLGLTSASAVNIKSLINNGDNSVCIVVGGAQESLLNSGNNERNVSKEIKLVLNKRKGFVKLAIELGNISLVPIFGFGEADIYNIIQPKPGTIGDTFQKWLKKNFSFTLPFFSARGIFIYDFGFLPYRNPINVCIGRPIYVPPNLRSKVPQELLDHYHKLYVDELKRVFEENKCKFGYENVVLNIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE19</accession>
    <name>G3BE19_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_109987</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE19"/>
    <dbReference type="STRING" id="590646.G3BE19"/>
    <dbReference type="GeneID" id="18246163"/>
    <dbReference type="KEGG" id="cten:18246163"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="750" mass="85956" checksum="75B432A40DF62EEA" modified="2011-11-16" version="1">MGLLSLGTPLDWYESRKHNEHVRDNGISQLINIFAQHQNRDNDKFYWGDEVEYMLVELDDNKKTVKLNIDYDHIIDDLNNSALEVGQKAVQNNVAFHPEYGRYMVEATPLAPFDGNILGHYLEVESNMRMRRFLSQTQLPANIRLLTLTSFPRMGCPGFTSPQAKPIGPASQSLFLPDEIINRHARFPTLTANIRKRRGCKVAINLPMYPDKNTKLLDDSIPDRELFDSDAEYRWASKPGHVYMDSMGFGMGSSCLQMTMQAKNIDEARYLYDALAPVTPLFLALSAAAPIFKGFLVNQDVRWNVISGAVDDRTFVERDLDPFPGYDYFGGLDIDKSVKSHLQKMGGGRGINGDRVFNVYGDTKLATNDGKSVQKIPKSRYASIDNYLVNESEIDKNFNDIYSPINQPVLQKLLKAGFDPIMAKHFAHLFIRDPLVLFSERVDQDNTLENDHFENIQSTNWQTLRFKPPSLYSTADVGDLKNKPGWRVEFRPTEIQLTDFENAAYTSFIILLSKAILRFRPDFYIGISKIDENMDTAHKVDAVTDDKFWYKSFNHWRLDANEFHGYDLSWFDRFINEGNDLEAYKQGYYNEPVHNAELTPDCIKHIPCVNNACKYTMNELINGNDSHPGLLRLIIKLIAIDLVPNTLKHCDSKILALKLERIKHYLMFVSKRASGKVPTIAHFLRSKVLNSPHYHKDSKVSDALNYDLIKLCDGITKLDFENYHDELYEYFGTAVASYVETNREVSFETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE24</accession>
    <name>G3BE24_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_116476</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE24"/>
    <dbReference type="STRING" id="590646.G3BE24"/>
    <dbReference type="GeneID" id="18248328"/>
    <dbReference type="KEGG" id="cten:18248328"/>
    <dbReference type="eggNOG" id="KOG3769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034765_1_0_1"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="66"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="364" mass="41222" checksum="269B6E0460B6CD7A" modified="2011-11-16" version="1">MLSRSFNILRGKPWGFSLVPVRTYQVSRNDESLKTEYDDITNYGSYKNTIFTHRLPESTAQQSPPLVALHFRLNLPKTYQFSTLSQALNMIKYEGLANNYGLNTLGKTLLSYYVSEYLLVRYPRLPMPIHNAAVDSLMGVESLYELGKAWGIQVDTTSKLDKKLSLESEFLQYGRLRFLSDQDKNQFTEEGIIELNLQEARTLNPNTNHFISREHDAYASAVRSIIGGLYTHCGETVTKKFIDDHILSRKLLLENMFQFSQPTRELARLCEKLNFKEPLQIRLMAETGRLSSHAIYVAGVFVGTEKLGEGVGSSLNEAKTRAVVNSLMSYYLYTPINEEGNPVKLPSDTDYKLEGIIGDGDVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEA9</accession>
    <name>G3BEA9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clc chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_136980</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689719.1">
        <property type="nucleotide sequence ID" value="XM_006689656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEA9"/>
    <dbReference type="GeneID" id="18250025"/>
    <dbReference type="KEGG" id="cten:18250025"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="998" mass="112130" checksum="0D1D6B763DE107D6" modified="2011-11-16" version="1">MSPNPIQQSGLNPKEELDFSNIDSVITSPKRHASTVPSSPSHLNVRFDKDQDKVRDAQKLNKIKSLGKIDIRSPIINHVFTSNSDLLQPNDDMSLYTPGTHTSVASRILSYVPETLYSIRNYYNDFTTIDWADAFIKTNRIQYELHHKHWITEGSSDQELSKNKIPLYYRAYHMMGRWVLIVLIAFVFSLVAYAIDKFEILFVGIKHGYCSTNWLASQVACCSEPHSPTKGFLRRNVFQSGFVMKSDVQEQCPSWISWSTYFSYTSWGHYIRFDYFIYVILSVLLAVIACFITLTTEIANRIPAASTEADDEEDGDQDNRRMKYTTGKKMYTAAGSGVPEVKTILSGFVIRRFLGTYTFLAKTTALVFAIASGMALGKEGPYVHLATAVGNILSRLFPFVSNNELIQKQILSAAASSGVALAFGSPLGGVLFILEEINHSLPSFQLFQIFFCAIISTLFLKFLDPYGTGNTVLFELNYTSDWNAIELIFFIIIGLAGGVFGALFVKFVAWWPKVFRSKKLIQEHPMLEVVLIAAITGIITFWNPYTKQATTELVLDLATPCSGEKDRTLCPTKGEEFIWESGSLLFALIIKIVLTFITFGLRLPMGVYVPSMVIGALFGRLFGTILEWINYTYSLSLIEAPIGAGAVNLICQKGQNCIDLGIYSMIGAGAFMAGVTRMNITLVTILFEITSSYTYVLPISISIAVANWMGNLIEQNSLYESLLIAYDYPFMSPETEPIDPLRTAGDIIETSVKYNDIDSEPNIQRIRPISGIARPMVPTLSTANLEAAMDQDSSTKMYIDITSSPYVLTSILKQKLLLLASKSLLDGCIALIKSKVCVGIIFFPELEICIDKIDQFCMEYEINEDLYCIVGDEEKYYFGNPAIDTLRDPIKFNLNVLKSSPACQSNDMDYFIYHSVDQDTDNNKLLTVYSSLMSLIDFTKHINYSPIFLNYNSELSLAHLVFDKIGNRVIVLLKDGQYYGVLHKKTLIDFIRRDNYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEB5</accession>
    <name>G3BEB5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_116570</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690376.1">
        <property type="nucleotide sequence ID" value="XM_006690313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEB5"/>
    <dbReference type="GeneID" id="18248357"/>
    <dbReference type="KEGG" id="cten:18248357"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="7">
        <location>
            <begin position="111"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV61162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="48891" checksum="0D79F930545026F4" modified="2011-11-16" version="1">MATVEVTTSSVDYKSSSKTTGLKTGTKGLVTLDTYGKEFKVPDYTIKDILSAIPKHCYERSLVRSLGYVVRDIVMMCVISYLGHRFIPQVQLEGYETAFKYIRGGLWCFQSYLMGLFGFGLWILAHECGHGAFSDYQNVNDFVGWVIHSYLVVPYFSWKFSHSKHHKATGHLTRDMVFVPYTKEEYVEAHQANKISEIMEESPIYTFLVLVFQQLGGLQLYLTTNATGQSIPGYSKIAKSHYAPKSPIFEPNQFWYIVLSDIGIISTFLVVYQWYLSFGIFHMAVNWFMPWLWVNHWLVFVTFLQHTDPTMPHYKDSEWTFARGAAATIDRDFGFIGQHIFHDIIETHVLHHYVSRIPFYNARDATKAIREVMGDHYRYDGTSMWIALWSCIRACQFVDDDNENAKGVMMFRNVNNIGVKPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BED2</accession>
    <name>G3BED2_CANTC</name>
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        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_127833</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="590646.G3BED2"/>
    <dbReference type="eggNOG" id="KOG4558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="304" mass="35281" checksum="D1E2ADEA76ED169E" modified="2011-11-16" version="1">MLQRHFMASWVPVFMNHINVQLEHQAEPFLTFQLSTIGIDGFPQNRTVVYRGFLFDEVSTNIITFTTDKRMPKYSELAKDDRFEAVFYLPGARKQFRFKGHARVIDADHHPIVKLDNYKPRDVGDIDSDDEDEAKESSVPEPSPNAFAPSPTTSIPKSEDTSFWNHPIEFHLVSPKLINQLHKDHNASYSNFNDIHVPHELTLKPPTDEEYAQELSRQWDTLSKALKKSFRKPDPGSRMTPEKSKLIDSIKRGVDGKKDIDGYKNFAVVAMFIDTVDFYDSESDRRVRFEKDKFDMWSEYEICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEE3</accession>
    <name>G3BEE3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_137005</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="590646.G3BEE3"/>
    <dbReference type="GeneID" id="18250029"/>
    <dbReference type="KEGG" id="cten:18250029"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021117_1_0_1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF51">
        <property type="entry name" value="MYB-LIKE DNA-BINDING PROTEIN BAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="89"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="92"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="149"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="611" mass="67715" checksum="EA3CE701E5B0419E" modified="2011-11-16" version="1">MEPTTKKLDKVDPLSVAESLGIRTYRKVSRNTWTPDDDAELIGTLKQISAVDLGEIDADTIDWDLLASKLTHQHRKPKDYKKRWVTSLDPNVRKGRWTKEEDDQLIEAYARFGPSWQKVASHIRTRTMDQCAKRYTEVLDPKTKDRLNPWSREEEMLLIKQIGIHGTKWRSIASNFKNRPALTCRNKWRTIALGVARGRAHPHIAAEVEKITSRKEVLDATADVSPASTSPASTGAQPLVPPSQSQLRHTSAEWRYTLTPSESTPASFMPPAKDMGVIKDEATVRLLLDYANSYGLKLDIHQHTHHHYAPPPHPFNHIAASPPDFANIGASPGLGPVQPSNRSIFLEPEAQLHRFQHFNYLPPLTEVPKLTSSSSPVMTASERNGRDIRQAQSPSGLTPLTQAAELAVGEVVRKRKNNDYGLDSTGSKKLKSEGDGGFFEQIRHLTDISQSSRGEPKSNGGTDGEGNISGQRPVSQHHPLHYFTGGTTPQANIPTPAAPRPTNRDEDEEEDEEMRSYGLFYQSYRKSRSNSHFEPGVPVPSTANPTANSAARTSNPATRAPATSAEAPPTASQEKHSPGSSNHENDHDHDGYNFVYENLLGSFGMMPFNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEE7</accession>
    <name>G3BEE7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116595</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690392.1">
        <property type="nucleotide sequence ID" value="XM_006690329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEE7"/>
    <dbReference type="STRING" id="590646.G3BEE7"/>
    <dbReference type="GeneID" id="18248368"/>
    <dbReference type="KEGG" id="cten:18248368"/>
    <dbReference type="eggNOG" id="ENOG502QSS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030508_0_0_1"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="111"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="367" mass="42749" checksum="8E7E156618633B44" modified="2011-11-16" version="1">MDETSPLIPQQESPSNAPQEPHPKPSRITHVIISMLIAAAIGTLTLHHLGQNTDFSYDRSTLLKPLTVRLYTNNIRYDNKHLDPHERSWSHRKPLITSSIQFNTFNTDQGNVVCLQEVLHNQLEDIMYGLNNDQTEGDWSYYGVGRTDGEQAGEYAPILFKHSEWIVADTKTFWLSETPEVPSRGWDAALERIVTMVTLQSKMNPLIKLNFFNTHYDHRGVMARRESSKLIVEKMKNYNNYPSFLCGDFNTQPTDEPYHILKDSGFKDSRTLVDKLHHYGFHSTFTGFNRHEEVNTIIDYIWAPYFALNGNRQPSQVETSDKNFFQFDFHRYYQIGIKNFAILHNWYDFYMSDHRPVSADYVVSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEH8</accession>
    <name>G3BEH8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116625</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689761.1">
        <property type="nucleotide sequence ID" value="XM_006689698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEH8"/>
    <dbReference type="STRING" id="590646.G3BEH8"/>
    <dbReference type="GeneID" id="18248375"/>
    <dbReference type="KEGG" id="cten:18248375"/>
    <dbReference type="eggNOG" id="ENOG502T76D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069662_0_0_1"/>
    <dbReference type="OrthoDB" id="4069757at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="209" mass="23787" checksum="5726DE0B5235154F" modified="2011-11-16" version="1">MNTSIIISELSRQDFIKTNHPMSLVDQIKLEILNIDYQGDEDYYLNKISTWSNLPFLSRVIIILKDEESSKQLYHYINSEIRSKYHLDPGVKVTLQENLLQRSKSFDGSTADDDSLSVNMLKRFKAAHSSETAKYQEPKPQIFDVFSMHRLGLHPQEADAEAVTASDGSSMARSRSMTRTLFKPPLSIETNLHCQSSMPSPTITLDETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEQ1</accession>
    <name>G3BEQ1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Purine-cytosine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115978</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEQ1"/>
    <dbReference type="STRING" id="590646.G3BEQ1"/>
    <dbReference type="GeneID" id="18248106"/>
    <dbReference type="KEGG" id="cten:18248106"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_2_1"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015856">
        <property type="term" value="P:cytosine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV59946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56551" checksum="DC368376B2586668" modified="2011-11-16" version="1">MSQEKDIGLDIEKKSFTSADHSIEDTGDVTHTKLGFINNLASRLNAETKGVEIITDEEKHDDSLWNAASMWFSANFVIATYALGCLGVTVFGLCFWQAVLSILFFNLLGVFGVAYFSIFGPKLGMRQILLSKFLVGNITMRIFAFVNVIACIGWGAVNIMSSAQLINIVNNQACPPWAACIIIIVCTILVTFFGYNVIHQYEKWSWVPNLAVFLAIIARMTMSKTFTFKDSYGGEMVGGATTAGNVLSFGGAIFGFATGWTTYASDYTVYQPRDVNSYKIFAWVIAGLYIPLVFTMVLGAACATGTITNTRWAELYNEYSIGGLVYAILVEDSLHKFGEFLCVLLALSTIANNVPNMYSIALSAQAFWSPLIKVPRVVWTIVGNFVTLAICIPAYYDFKDVVDNFMNMIGYYLAIYQAIALSEHFIYNKNNFGAYDYENHKDPKSHPLGLAGTFAFLAGVAGAVCGLNQVWYMGPIAKKIGDYGGDVGFELAAGFSFIAYNITRPFEKKYIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BER0</accession>
    <name>G3BER0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_126628</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BER0"/>
    <dbReference type="STRING" id="590646.G3BER0"/>
    <dbReference type="GeneID" id="18249184"/>
    <dbReference type="KEGG" id="cten:18249184"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV59955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="298" mass="32538" checksum="94C264E815E09DF6" modified="2011-11-16" version="1">MEQQPPRSLANVKHIVLVLSGKGGVGKSSVTTQTALTLVNKGFDVGVLDIDLTGPSLPRMFGVEKKQVFQSTNGWVPVSVYSNALDPVEKNGKTRRGNLSLMSLGFLLGDRGNSVVWRGPKKTAMIRQFLKDVVWNSGSSSKPLDYLIIDTPPGTSDEHIAIAEELRWASPIDGAIIVTTPQQVATADVRKEINFCQKIELDILGIVENMSGFICPYCAECTNIFSSGGGKALSESLNLDFLGNIPIAPKFVEFIEMQDNEENDGKRKLIDLYEECELSPIMNGVIDKILAKDLPSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BET4</accession>
    <name>G3BET4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116666</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BET4"/>
    <dbReference type="STRING" id="590646.G3BET4"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442669" description="HTH TFE/IIEalpha-type domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="410" mass="46036" checksum="6D23ED68CB164E29" modified="2011-11-16" version="1">MGLHLRTRAVFLCLARAVPPTREKCETTEFVTSSSTMDDTIRSLIRFVVRGFYSKEYILIVDAVLIHSVLSEDDLIYLLGIQRKELRMFCNKLVDDRLLGAQYQKEENPQSRQISRTYYYIHITEAVDSIKWRAHFVVNKIKQEMNQFGNPHGYICKRCTKKFSQLDAIALLSSDRSSFVCDNCGFSLVEDDSNEQASIKQESLEKLRTQIDPIIDFLKKIDESVVEDNTFEAALVNAIPAQSSSLGSYSLPSRFKNSKLTANSTANLKSQAATLHVSITAVDENEDKERQIREEKIQKIQQNALPAWHSASTVGKETPSANQTPEPPSFKSEPEIASASGPIKSEFESSSGTAVADETPAPVEMSSELKDKEAQDALTAYYAELAAREAQDDDDEDEDDEDDFDDLEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF07</accession>
    <name>G3BF07_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_136488</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF07"/>
    <dbReference type="STRING" id="590646.G3BF07"/>
    <dbReference type="GeneID" id="18249978"/>
    <dbReference type="KEGG" id="cten:18249978"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_10_2_1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000014">
        <property type="entry name" value="Mitochondrial NADH kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV59980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="296" mass="32961" checksum="0A20B5389EB51BFC" modified="2011-11-16" version="1">MVDIINYISQHHQHANIILSEHNIDELQHPSAGGHSLDDRVRLFTGEVKDIRFKADVLMTIGGDGTILRAVSQFSNFNVPPILSFSMGTLGFLLPFDVGSYRARVDELFANRLRVLQRSRLECHVIGTHPSEARVNMVHAMNEITLHRGSNPNLISLDVYVDGECLTSTTADGIIVSTPTGSTAYSLSSGGSIVHPSIRGLLLTPICPRSLSFRPLILPSTSDIMIRLSQKSRNVSVKLTIDGIELSDMRHGDEIHIRKQLDIDNHIWCMAQGDNDWTKDINDLLGFNKQFNESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF47</accession>
    <name>G3BF47_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NOL1/NOP2/sun family putative RNA met</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116701</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF47"/>
    <dbReference type="STRING" id="590646.G3BF47"/>
    <dbReference type="GeneID" id="18248410"/>
    <dbReference type="KEGG" id="cten:18248410"/>
    <dbReference type="eggNOG" id="KOG1122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_7_0_1"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000192">
        <property type="entry name" value="NOP2p rRNA m5C methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000009">
        <property type="entry name" value="Nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="95"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="357" mass="39372" checksum="B281F82483C00287" modified="2011-11-16" version="1">MEFFEANEIARPITIRTNTLKTRRRELAQTLVNRGVNLQPIGTWTKVGLQVFDSQVPIGATPEYLAGQYILQAASSFLPVMALDPQENERILDMAAAPGGKTTYISALMKNTGCVFANDANKARTKSLIANIHRLGCKNTIVCNYDAREFPKVIGGFDRILLDAPCSGTGVIAKDESVKVNRNEKDFIQIPHLQKQLILSAIDSVDANSATGGVIVYSTCSVAIEENEAVVDYALRKRPNVKLVETHLQVGKPGFVSYRGKHFDSSLSLTRRYYPHTYNVDGFYVAKFKKIAPSPHDVSKAGANEKELLARAEAEEEGIINDDFAEFDNDEDADLMQKSIKRSMKKKGINPSGTKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF72</accession>
    <name>G3BF72_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_96104</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF72"/>
    <dbReference type="STRING" id="590646.G3BF72"/>
    <dbReference type="GeneID" id="18250579"/>
    <dbReference type="KEGG" id="cten:18250579"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_1_0_1"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="146" mass="16575" checksum="20E71801FB1C336A" modified="2011-11-16" version="1">MSSYGIADLRFIKASTVYSWFKGGAPGRFAVVDVRDSDYVGGHIKNCLHVPAANFHETLPALRQKLFDMKVQDVVFHCALSQVRGPSSTLKFLRSLEEIKDPQQIEFFSNLSVWVMQGGFTAWQQKYGEDESVTEAYDKEIWDFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF90</accession>
    <name>G3BF90_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-signaling factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_126748</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF90"/>
    <dbReference type="STRING" id="590646.G3BF90"/>
    <dbReference type="GeneID" id="18249193"/>
    <dbReference type="KEGG" id="cten:18249193"/>
    <dbReference type="eggNOG" id="ENOG502QT03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_719597_0_0_1"/>
    <dbReference type="OrthoDB" id="4076669at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022757">
        <property type="entry name" value="Gsf2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11055">
        <property type="entry name" value="Gsf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42951" checksum="06F12D830D775128" modified="2011-11-16" version="1">MSDEKNIVDAAQEAEEGFLECYIRFNDDAEKDYCFQVSVNTQFNDLFRIFSTLPISLRPSIFYSQKPAGFKISTAPGYLTDDGAILFDHDATSEKYLQTIDLSDKIGDKIWPGQLIVPVWERNTFGYYAFVTGLLVWLYTDLPDFVSPTPGICLTNQMSKFVCWVLTKLGKPDLGKVFIEDLYDETGIAPQMVFFCMHLIKVSIIYLLVNLGIFNPIKLFKIPGTKGIKKDVTRDELLHLGWTGSKRSTIEEYREYYRNFRIKQYKSIVEAQQDGLFTRLRVLGVQLKDGEGYNTPLDKKSTLKDLLNKDDIKFTLNYAYLAKLSNLFEKHIGEPEVDINEAVKQFRRYGLCKRDSVIEEIVELRKSVEVKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFA5</accession>
    <name>G3BFA5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_126784</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFA5"/>
    <dbReference type="STRING" id="590646.G3BFA5"/>
    <dbReference type="GeneID" id="18249196"/>
    <dbReference type="KEGG" id="cten:18249196"/>
    <dbReference type="eggNOG" id="KOG0529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031996_0_0_1"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="382" mass="45784" checksum="B40CC582D34C7410" modified="2011-11-16" version="1">MYLCLESNAKFQLYLHRMFHNVKREKLNQEARVAKIEKDKPKIESYLSLQSLVFEARQNHQYTVESLNKTTDLLMINPEFYTIWNIRRETLLELFAQKQLDKVKTLEDDLKMIMVLFRRFPKCYWIYNHRLWCLRCLGQSANWQVELAIVSKLLSVDQRNFHGWHLRRIVVHNYEVQTPKTPQELLSIYIKEFEFTTSKVNQNISNFSAWHNRSKLIPKIYKYYQEVDSEFIDQAEDLNKYTQVFSSRLSLLQHEIKLINTGMYVDVDDTSVWLYLYWLLSDEFFTEHLDKQVYQRTLEEQLEIIRELNELEKDDNGKDNCWCLKTMILIKCLLANVHNNNSAPSDLLTDEIKSFLEILADIDPLRKGKYLDQLHGKAELLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFN2</accession>
    <name>G3BFN2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_116085</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFN2"/>
    <dbReference type="STRING" id="590646.G3BFN2"/>
    <dbReference type="GeneID" id="18248159"/>
    <dbReference type="KEGG" id="cten:18248159"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_7_0_1"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000093">
        <property type="entry name" value="Type 2C protein Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="107"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="367" mass="40708" checksum="D4776D59A8D84754" modified="2011-11-16" version="1" fragment="single">MFHHHRSLTTVCTYIFVFMIGLMISSVAKRGIPHVLSKSSTLPISFLSLNSRRCFSFSSSYWNLNNDAKSSASSEHTSAGNIGSDDLFSIAFAYQPKDREESNVFKRKNKKLSPALESPTGEDNLFVSAFKDGSVAVGVADGVGGWSEAGYDSSAISRELCNFIQHNFEASPHTSPKDLLIKSFADVLQSPKVEIGGTTACLGVFSNDYTVKVANLGDSWCGLFRDYKLVNETNFQTHNFNTPFQLAKIPQHVLRQAEMAGKRYIVDKPEFADEYTWKLQKDDVVIFATDGVTDNIIPQDIEIFLKDRFESGLSQEDITKSFVKEVVSVSKNPNFPSAFAQELSRLTGQKYLGGKEDDITVVLVKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFT0</accession>
    <name>G3BFT0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_100076</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the BOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFT0"/>
    <dbReference type="STRING" id="590646.G3BFT0"/>
    <dbReference type="GeneID" id="18245358"/>
    <dbReference type="KEGG" id="cten:18245358"/>
    <dbReference type="eggNOG" id="KOG3251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078260_1_0_1"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV60724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="231" mass="26704" checksum="6CEA77FB2B80612E" modified="2011-11-16" version="1">MNSLYNHGLKQTQLLSKDLSSFEKNLSTSPLSLQGSISTSLTSFRKTVKEYGDLIKQNAKDQSIAKHDARLERFEQELADFTRKFDDLKVQRESTIHESNRQELLGRRHTQHVSDNPYDQTGGSEPASQQQQSQSMAYSEGLYNEKNALQRGSQQLDQILEMGQQAFEDIVEQNQILQQLGARFESSLMTLGVSQTTIRTIERRARQDKWLFWGGVIIMFVCFWYILKIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFW8</accession>
    <name>G3BFW8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112050</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996531">
        <property type="protein sequence ID" value="EGV59915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFW8"/>
    <dbReference type="STRING" id="590646.G3BFW8"/>
    <dbReference type="HOGENOM" id="CLU_098504_0_0_1"/>
    <dbReference type="OrthoDB" id="4070235at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442838" description="PA14 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="32"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV59915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="247" mass="26777" checksum="250CA0D88B9C8DDF" modified="2011-11-16" version="1" fragment="single">MKFHYTLLSIGIFQFIRSVSSADSVGGCSPTPVDKGLYAEYIEVAENEWTVGDSASLESGLAVVSQREAEYSWSGVTEQDFWIYPGTNVLYGHDVTTDHFGLRLTGYLYAETTGDYTISITFADDAASLSIGAGVAMECCGSSQFPTAVTEYAHWYAEGESTSVAKTVHLTAGVYYPIKVVFMNVVSGAHFNMSVTYPDGTNHTTDIDWYSSTNNSTSCPYSTTTTNIWTGSDTEYFTVTGSDGDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW35</accession>
    <name>G3AW35_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyoverdine/dityrosine biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_100455</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW35"/>
    <dbReference type="STRING" id="590646.G3AW35"/>
    <dbReference type="GeneID" id="18245381"/>
    <dbReference type="KEGG" id="cten:18245381"/>
    <dbReference type="eggNOG" id="ENOG502QRI9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025510_0_1_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49919" checksum="40C1B395EB918F81" modified="2011-11-16" version="1">MLLRELSKLPQTTSDFQYLKSLEISHIPLLVWERKQDCGAIGVVTRVIPDDAFNKWAINLLLSTSKIMYPPSEFSHQIYTDIIVELFETMLKNTAAKDKWEEEGESYFKTKVDFYTSKGLKIEAVLPAFPCKSSNPDKVSGYMPDKGEEMALRTLCDFASAVKKVYPPGILIWIVSDGHVFSDCIGVDDLTVNAFGFSLKELYHRINTSGEEMIRFCSLIDLFNLHNKPVDEEILDEIHLSHHIATEIDPTSENCRKILMKSCDTDWGQLKEDINTPNHPRLFLFRGFSKFMEEDLKQHPTIIAASKKKSKKIVAKIAFEMIKRNDAYSNLMELIFPMHLRFSIHAHTNSGPKYGIKLLSNKHCRVINSLEECSSPNYDDLLHIPTPWHNTVLKIEGDSMYYVTKTNNIMKAIQEGTYTGGWDKKSGCFELKARSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW37</accession>
    <name>G3AW37_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112176</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW37"/>
    <dbReference type="STRING" id="590646.G3AW37"/>
    <dbReference type="eggNOG" id="ENOG502S3SW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061432_0_0_1"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="62"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="386" mass="44355" checksum="7248064D7E531D87" modified="2011-11-16" version="1">MFPESSEIYNYTNKTTIASEPRFSGAVVLEKPSTNSADYQLQIAYRLYNRKTAVKSGPKVNLVFHHGNGMNKGIWHYQIDQWFNILPNLDSVLAVDCVSHGQSAKLNRGKLGYAVSWIDIAKDVIKVVKYDEKDIFLQPNVVNIFVGHSLGGMVSFITAYFEPTLFDAIVPLNPVAQVDQDRADLLSMVFQRWQETEKISNRYPVEKGETYEDAVWRYYKTKSFFKKFDDKILQNMLEDDYTDERSIKHGFAYTNTDAQQEFLLYFGGSPSIARIQGIYDQITTPVYHIVGEFDTAGDTAVEAIRESMKKVIHPIDIPKATHLVNAESPQLFVEILRNIILERVDIFHKSGDIRYPDSHYLKTIGIDYKSQLLKRHFEEGFLSYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW65</accession>
    <name>G3AW65_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112190</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW65"/>
    <dbReference type="eggNOG" id="ENOG502S1H5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092512_0_0_1"/>
    <dbReference type="OrthoDB" id="4089816at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27992" checksum="889EF9781011C9A9" modified="2011-11-16" version="1">MTEGNKQKTDQSEQIALSEHSDTSESSSNVEEVIDSINGSTSRISRDHGTNNHNGGTDIHSQIHNTRASEPVGSSDEDDYLLSDDNVSEETTFSGEGHRMGYNATLSERADYLAGTLDHALDSLELDKSLVVQAQLSGMLNNENQNITEKRQQILEKLKMLQDLLHKNFEPRFDPETNTKISVVQKLNHDIKNIETRIRVLKEGRKDKGVMSFLGNSKNVKGVMSLYPIEYSQARDKVLERQIDEDIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWM7</accession>
    <name>G3AWM7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_91743</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWM7"/>
    <dbReference type="STRING" id="590646.G3AWM7"/>
    <dbReference type="GeneID" id="18250108"/>
    <dbReference type="KEGG" id="cten:18250108"/>
    <dbReference type="eggNOG" id="KOG3964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="536" mass="61506" checksum="422468A8E22091F2" modified="2011-11-16" version="1">MLSSVYNYVFGRNHIHLSAVSTNNIPQDQVTQKFHPRLQAIFKQLDAICPRFVISQNDVFILNDPEQFYSTLKEKILSAKQRVFLSSLYVGKTQHELVGTIEKALELNEDLTVSILTDALRGTREAPHQPCSASLLVPLVEKFGKHRVDIRMYHTPHLKGFTKSLAPKRINEAWGLQHMKLYGFDDEIMLSGANLSEDYFTDRQDRYYLFSNRKLTEYYSKIHDSICSISYQILPSTNTPSGFRMDWPTSNKTCEPHVNHARFISDTSFMLEPLLKQQDLKNFEEFNDSDEYDTIVYPISQFSPLLQPRNDISTEKPSVLRLLTFLDSPTIKWWFTAGYFNLLPEIQEKLVNGVAKGTIITASAKANSFYKSTGVSYYIPEAYLLIAKKFLEDIRAKAKDNLIKLYEWRNGVVNTPGGWSYHAKGIWITVPDEDLPSITVIGSSNYTKRAYSLDLESNAILITKNKGLKKKMKEEVDNLLKYAHPMELEQFEPKVIGYEKNENDEDILERPIKKVSEDRQISYGVHLGLKVIGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWS8</accession>
    <name>G3AWS8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar carboxypeptidase Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_91779</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWS8"/>
    <dbReference type="STRING" id="590646.G3AWS8"/>
    <dbReference type="eggNOG" id="KOG2063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_290702_0_0_1"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="4">
        <location>
            <begin position="17"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1033" mass="119551" checksum="CF5CEBE91F4A66E0" modified="2011-11-16" version="1">MNIDVIRPASRLNSSSPVKITAVYYDKEKLYVGFASGDFSIYDVDIITESDQRKAPSITSFKSLTDIRTYFMDTKSSNFHHDMTFPNVNGDSTPVSRIEIVSNNSSTNRIIFAITNNDIIRIFEKIGNHLNLIQVMDETKAYHELLVYEVNGKKHMTVGVKKKLIIFEMVYKTRNLFRFNKISEQSLKERVKAISCMNLQLGLHLIIGLSNDFLLVDVNDDFRITGLFPENSDNNEMYYYFNHSTFSYFGLSSSGPSIRILKANEDEYCLIKDNQIIILSSKDSAISVKESNVKLSASPVFLSFIYPSYLLVVYNKKVEIIDLESGELVQKIHHQINSNSIPVFVNDAFIFLGANTDLIQFNILNFQQQIDQYLRFGFGDDRRNSKKDPKTDLALVGLQRALKFVEKIDEEDEFFGGSRVGKEKKKQLMLRDLNKQRAFILFERYGKYHESLIEICSDWLVSYKDVLDLFPDFLKREFYDRSNATIANEALKNTRNVVKKITLDELQQSKLNALTTADSATEVENDRSSKATLTSRMPSTIFGQTKSQNLRKFGKAINNLIIYLTDQRRIHLAFLNDEGFFWKGINITPVDLYDFITPELMTSSLNQIAIEIDTCLFLCYFYCKPMLLGPLLRLPNNCCDASIVNQCLLSNHDSDNNFLKELLDFYFGRKLHKEALEMLYKLAHEDNDNEALESGGISHLTIQYLQKLGNIELGLVFEHSKWLLTDPDQDPMLNGKLIFMNETYECESYDNFKVLEYFVEVICSEELAVEYLEWIIFESDFNDQPNKQHIMPKFHTKLCLMYLNILKEMDRNDAGFETSEPYQKLYKFLQTTSLYEPWTVLKHIPTNEVKLLRFTIFIYKRLGEHDKAIDVLYGQLDDLDSAIKYCSDIYTENNKDLGTKLLHKLLEDLLMNYTENTDSISKLLKSQGSKMDTLRVLTSLPPSFPVRKLDRFLSNQYRMSKKTLVDSRLASQLYKVGNIKLQHELLMRSNKSYTIESSKKLCPICKKRLGYSVFTVRNDQIVHYACYQTEVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWV3</accession>
    <name>G3AWV3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_117728</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683884.1">
        <property type="nucleotide sequence ID" value="XM_006683821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWV3"/>
    <dbReference type="STRING" id="590646.G3AWV3"/>
    <dbReference type="GeneID" id="18248590"/>
    <dbReference type="KEGG" id="cten:18248590"/>
    <dbReference type="eggNOG" id="KOG2330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014435_2_0_1"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="271"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="458" mass="52235" checksum="E545444FECD60A96" modified="2011-11-16" version="1">MSKVRLSKNQLRREKLKKRKLNSNDTDEQKPVPKLHAPPISQSADTRNKDEDVKPNPSVESNLYKEFESIFSKFEGSNEKKDNDSTNYSDLVAKTDEDKDLVSDEDSDEFELEDEDVIESKSQLQRQNKVSMAHLKAVARNPQVVEWADVDANDPYLLVSIKSNLNVVPVPSHWSSKRDYLAGKRGVERPPFQLPSYILETGIQDMRNSSDESTLRQQQREKVQPKMGKLDIDYQKLHDAFFKYQTRPKLLGYGDVYYEGRETTDENEDKLTEVKPGKLSVELLKAMGLPENGKTPPPWISTMSQIGKPPTYSHLLIPGIDITYANVGYLVNDHEVYGQDSDDGHWGDVQVEESSEDEDDGDEDESDDESEPDPTVQPTYFEEESSKDTGDEIVIHQKPSNDSSKNKTLYTVIKENEAESTNGLLESERKYQLNDDNPTEETTKTEELQAKPARKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX92</accession>
    <name>G3AX92_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_117943</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX92"/>
    <dbReference type="STRING" id="590646.G3AX92"/>
    <dbReference type="GeneID" id="18248612"/>
    <dbReference type="KEGG" id="cten:18248612"/>
    <dbReference type="eggNOG" id="ENOG502QR1M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340424_0_0_1"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="705"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="830" mass="94208" checksum="F93091E34FCDD5D6" modified="2011-11-16" version="1">MVVETSERRRIPACERCRLRKTKCDSRVPSCSNCLKATVDCMNQDKVLGRTHLRSYFFGTGEEPQSFEEPTTAIDKQVESPQIHKRPRTSTSQYSSISETRSPYSSTLDPQSGHSDSDDDDDSSIYSNQEDYDPGRRTMENLLASSFNGGSASSVMSDLDNIRQYTSTGKSPREIFIENENNAISKLGRDFLKQGRRTYRKNRVTDITAYDYNLLTRLTRRYFTWMNSANQVLHEVMLHLQLDKCRNNPEKATAVDLFQVKMVIAIALASISRPHISNSEIGRIALVFWKSANKTIGSVFQGHGISKLQNILLHLQYTLLVPKTGNLWQLSGTAMRLATEMGLNGEPDPSQYFDPLSLDLRRRLFWTCYCIDRILSTSMGRPTSIHDTWISAKVPALVEDRLVTVKGIESGPMCHLKVSHIQQIRICRLQSEIYNQLYAPSKRPKITNEQLEIWSWQTYDELRLWRCTFIHPTPLITKEWFELQFHIAVVLLFRPSPNRPKLSLDALHVAFHSAGEVMRLVRIMHREYSAVFSWLTVQNLFMCGLTFANSLNELAKQTNSHQICIPFYEIFQQIQSCTAMLETLSALETGANDRIRNAFEMISSSVIQTIANIAPSLPKQSSHQGCIWAQIAKVDTITLSRPTQINGTVIPIKGQSEVLGSTNLRLWDNTSNEEAAKTHFMEHDRDASLVNSMLKKPIDSESFTIADESKASVDSNQKRNREDTVESHNSHSNHNNQDGSTRAHFHGQIHDHSTPDSRCIQGLVSSEDPQIDRVDALTIVSAQAEPLQDMSGVTNWSEVSLGAELERWFFYPLPESSERYLGRVNSPFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXF7</accession>
    <name>G3AXF7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Superoxide dismutase</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_112109</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXF7"/>
    <dbReference type="STRING" id="590646.G3AXF7"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_2_1_1"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="11">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="12">
        <location>
            <begin position="120"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV66739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="223" mass="24785" checksum="39470A48D93C9A79" modified="2011-11-16" version="1">MLSIRTASRGVSKIPTSSIGAIRTKVTLPDLDWDFGALEPHISGQINELHYTKHHQTYVNGYNQAIEQHAEATSKGDVKKTIELLKNINFHGGGYTNHCLFWKNLAPAKNGGGEPPATDSELGKKIAEQYGSVDSLISLTNTKLAGIQGSGWAWIVKNKENGAIEVTTTYNQDTVTGPLVPLVAIDAWEHAYYLQYQNVKVDYFKAIWNVINWKEAEKRFLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYJ5</accession>
    <name>G3AYJ5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112735</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. Interacts with RSA4 (via WD repeats).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYJ5"/>
    <dbReference type="STRING" id="590646.G3AYJ5"/>
    <dbReference type="GeneID" id="18246654"/>
    <dbReference type="KEGG" id="cten:18246654"/>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070048_0_0_1"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="261" mass="29494" checksum="650A5316667906C5" modified="2011-11-16" version="1">MPQNEYIEQHIKKHGRRLDHEERKRKREAREGHRISKDAQTLKGWKGKQFAKKRYSEKVAMKKKIKAHQESKVKGPSTPAAESGEALPTYLLDRQNDNTAKAISSSIKQKRLEKADKFSVPLPKVRGISEEETFKVIKTGQKNSKAWKRMITKHTFVGEGFTRRPVKMERIIRPSALRQKKANVTHPELGVTVFLPILAVKKNPQSPMYTQLGVLTKGTIIEVNVSELGLVTAGGKVVWGKFAQITNEPDRDGCVNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYK7</accession>
    <name>G3AYK7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_133301</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYK7"/>
    <dbReference type="HOGENOM" id="CLU_1959279_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="128" mass="14628" checksum="283ECF60DB6F3524" modified="2011-11-16" version="1">MEFRPLSSPTGLEFEEQDIDFRHIPGIETKMKCSHAFEIVAMDRHLSGCMALGPSIFKKTVVLDNNSHTDPSDNDRLESNHEINSNDRYGKKLNLSSSIIEDSDEEAFDEEYDEFTKYLSSHTPHTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYZ6</accession>
    <name>G3AYZ6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_118961</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYZ6"/>
    <dbReference type="STRING" id="590646.G3AYZ6"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001442_1_2_1"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="190"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="415"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="753" mass="87181" checksum="93C5F5625F0E893C" modified="2011-11-16" version="1">MEHIYCGDPELVIEPDHYSGGVPVFKPTFAQFKDFYKFNKAINKYGMQSGIVKVIPPFEWVKSTSGSYSKKNLDTIKIKNPIIQHINMSGNGVYNQQNIERARTYNIFQWKDLSEKSNHQPPAPKGKTRKESPNKMNLRPHKRTPSHTDYNIDTSEFTTERCEQLENTYWKSLTYAEPMYGADCLGSVFSNSVKSWNVARLPNLLDMMEEKLPGVNDAYLYAGLWKATFAWHLEDQDLYSINYLHFGAPKQWYSIPQEESGRFFDLMKETFSDEYRNCPEFLRHKTFLVSPQFLEKYGIKCNKIVHNEKEFIITYPFGYHAGFNYGYNLAESVNFALDDWFPYGEDTKKCECISDSVGINVKQLYCKFKGIPYEMPDLTSDDGDEDDEHEDIDKQVEPKMPKSKKATSSNSPHETKECYLCPNNLPKQLLEKYQFELLQTDFKGYKVHRICSLVFPKELENQNDKIVGLTNISKAQKSLKCLTCSQKGVGACFQCSYGKCYRSYHATCSLKDGASFDFAKNEFICKYHYQKYNDGHKIIPSDLKTRNLTQFKVGNHYTCGFVNTNNVNKETLRVSIYPDMEEIKEFKYDEILSIDGHIKMDTFFLAGKTKRKERERKPKEHTPVDDYVVTGLNENNLDLRMQENFIVETVNNDFPSCKFKELWYNLPEFSNDVADRYTSDIKNNYPNDPFFLKQMKRKKRESLTNPNPNSNPDTSYISYSPSSVPSMAVASVPNPDSRLPPLFTFIHGPGTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ90</accession>
    <name>G3AZ90_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_102078</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ90"/>
    <dbReference type="STRING" id="590646.G3AZ90"/>
    <dbReference type="GeneID" id="18245529"/>
    <dbReference type="KEGG" id="cten:18245529"/>
    <dbReference type="eggNOG" id="KOG1112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_1_2_1"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="787"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="826"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="863" mass="96608" checksum="604C4A6D26104B29" modified="2011-11-16" version="1">MYVYKRGGHKEPVRFDKITARVQRLCYGLDTKHVDAVAITQRVISGVYQGVTTIELDNLAAETAAYMTTIHPDYAILAARIAVSNLHKQTTKQYSQVSKELYDYINPKTGKHSPMISDETYAVIQKHADELNSAIVYDRDFNYNYFGFKTLERSYLLRIDGKVAERPQHLIMRVAVGIHGDDIERVIETYNYMSQRYFTHGSPTLFNAGTPSPQMSSCFLVAMKEDSIDGIYDTLKTCALISKSAGGIGLHIHNIRSTGAYIAGTNGTSNGIIPMIRVFNNTARYVDQGGNKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMERVEANGDWTLFSPNEAPGLAEVYGDEFKQLYEKYERENRGRQTIKAQKLWYAVLEAQTETGTPFMLYKDACNLKTNQKNLGTIKSSNLCCEIVEYSDPEEVSVCNLASIALPSFVETDETSAWYNFEKLHDISKVVTRNLNRIIDRNYYPVPEAKRSNMRNRPIALGVQGLADAFMALRLPFDSQEAKELNIQIFETIYHGAVEASIELAATEGAYESYPGSPASQGLLQYDLWNRKPTELWDWDTLKQKMAKHGLRNSLLVAPMPTASTSQILGNNECFEPYTSNMYSRRVLSGEFQIVNPYLLKDLVDLGLWNESMKNNIISNNGSIQGLTNIPDQIKALYKTVWEISQKHIIDMAADRAAFIDQSQSLNIHIKDPTMGKLTSMHFYGWKKGLKTGMYYLRTQAAAAAIQFTIDKNSIASANDTVAALEMLNKRKYKAVGSAIGSADEGDADLSISTRSGSTEPSSIENSIADLKVSDDKPEEPQDVAEGEGEGETEADIFSSKVIACAINNPESCTMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ92</accession>
    <name>G3AZ92_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112898</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ92"/>
    <dbReference type="STRING" id="590646.G3AZ92"/>
    <dbReference type="GeneID" id="18246728"/>
    <dbReference type="KEGG" id="cten:18246728"/>
    <dbReference type="eggNOG" id="ENOG502SE1Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172736_2_0_1"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7494" checksum="F2823BF2C4AF9273" modified="2011-11-16" version="1" fragment="single">MGAAYTIFGKQVPSHILAILTLGSVAGVVAYPRSKSEATPTPTPAPAVTVASKEDDFDLEKFINDLSKEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZA6</accession>
    <name>G3AZA6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_112908</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684867.1">
        <property type="nucleotide sequence ID" value="XM_006684804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZA6"/>
    <dbReference type="STRING" id="590646.G3AZA6"/>
    <dbReference type="GeneID" id="18246731"/>
    <dbReference type="KEGG" id="cten:18246731"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_2_1_1"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23286">
        <property type="entry name" value="beta-trefoil_MIR_PMT7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="312"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="378"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV66293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="735" mass="84503" checksum="A5A1F7007BC99A6B" modified="2011-11-16" version="1">MSEVKLPPGYHQGIARPYYTSSPIPAVVGRAVLGNIDRFCLFSLLAVGVLVRLYKLPYPSEVVFDEVNFGSYIHEYFHGRFFIDVHPPLIKLLYYWCAILFGYDGEFEFSHVDEKYDQNVPYVALRLVSATCGLVTIPVTYLILRHNYCGPVSALFGSFLVLIENSMVTQSRFFFLDSPLILFTAVTMLGFSMARNSTAFSGRWHANWLLTGVFLGLACSSKSSGLLTYGWIGILAFLQLWTVLGDLEVSDFGWWKHLVARIVYLVGVPFTIYLAAFSLHFHALPNVGPGAGPMTPQFKATFKDYDTIRKEPVEVVYGSTVTLKHNEVGKYLHSHPFNYKTGSKEQQVTLYSYHTDYNNEWEIHPKTKRTDMRLFDQVNPIKNGDVVRLFHKATGKFLHVNNVRPPITEKDYANEVSCNGTRDLLGDINYEFKIHILDKKPHSKNNLPNIKLRATESVFQLFHQGTRCSLVAHQGKLPGWAFGQNEVLCINQPTIPNTLWYVEYNSHPMLDKDQSSERVNLGGLTFWKKFVEYQKVMWMFNKGMGGSHEYGSRPEAWPFLIRGTNYYSTDARVKTADEPGSHIYYFGNLAIYYFGVMAILFIGLKQVFYLINHLNPFMLPNETTNVSMFYQATMETILGYVVHYQPYFMMERELFLHHYLPAIYFCILTVTYFVEYQISKRKLFGYILVGVIGGLSLGCFVYFSPLIYGTDWSREACREAKWIGSWDFDCRTYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZI3</accession>
    <name>G3AZI3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112466</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZI3"/>
    <dbReference type="STRING" id="590646.G3AZI3"/>
    <dbReference type="GeneID" id="18246530"/>
    <dbReference type="KEGG" id="cten:18246530"/>
    <dbReference type="eggNOG" id="KOG0418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_1_1"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14311">
        <property type="entry name" value="UBA_II_E2_UBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000080">
        <property type="entry name" value="UBC1p Ubiquitin-conjugating enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="219" mass="24438" checksum="D0F7465371D96EE9" modified="2011-11-16" version="1">MSRVKRIAKELEECKQDSHSGVSLKLNNETDLTHLTGVFKGPPGTPYEGGNFQVDINVPSEYPFKPPQMKFITKIYHPNISSVTGAICLDILKDAWSPILTLKSSLISLQSLLQSPEPDDPQDAEVAKHYLSDKKGFNDTAAYWTKIYASDVDAGQAELSDSALYGIDNDIVVQFENMGFPRDKTIEVLRRMGIKNLNSVSNKSETENKILEELLKECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZI4</accession>
    <name>G3AZI4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112468</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684160.1">
        <property type="nucleotide sequence ID" value="XM_006684097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZI4"/>
    <dbReference type="STRING" id="590646.G3AZI4"/>
    <dbReference type="GeneID" id="18246531"/>
    <dbReference type="KEGG" id="cten:18246531"/>
    <dbReference type="eggNOG" id="KOG0116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036630_1_0_1"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="36"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="406" mass="45016" checksum="F1A2F46CF4070B09" modified="2011-11-16" version="1">MTSSSDVGGSDTKGEAGQTDAKPSAVKLGLDRANSIGWFFIESYYEMYNKNPENLYKLYNSEASISHGDIPGVSQAVRQATGTESIKSLYKDLQAAQIKNKIIVINADIQISLRNSILIVVNGEWSKNSSPYYQFNQTFILSCGINESNYEVANDILRFIDYDFKHDKIVEKEKQTEIAVVEELAEEEPTQNGVTVDDVDEPAEEPEEVAEEQVEESEAAKSDVSEKEQPEPELEAVEFDKEKTEEPAPASGPLSWAALAATAKDKSPKPASVPKTAAKKPTGVATAPTPVPSPSALPNGKYKKEDWFPIYVRGCEDIKEDDLKDHLKMNFGEIKFFKQNSNIALIDFLNVDGQRKALGAKKTVVNGITIFLEVRESKNGRKDPKAKEKPHDAKRKNDKKQVPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZL9</accession>
    <name>G3AZL9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADPH-dependent methylglyoxal reductase GRE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112488</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684189.1">
        <property type="nucleotide sequence ID" value="XM_006684126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZL9"/>
    <dbReference type="STRING" id="590646.G3AZL9"/>
    <dbReference type="GeneID" id="18246541"/>
    <dbReference type="KEGG" id="cten:18246541"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="BRENDA" id="1.1.1.283">
        <property type="organism ID" value="1144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="335" mass="37196" checksum="E5F62119D8E2B393" modified="2011-11-16" version="1">MSTPVVFVSGFTSYIALHIVKKLLARKYKVIGSGRSQSKSQHYADIINDPNFSFVVVAQLDADDGFDEVFKQHQDITYVLHVASPLILDPKDPEKELLLPAVHGTTNIMRAAQKYGPNVKRVVITCSYAAHCSPLDHYGKPDSIITEESWSTITYEQSLQPQNAYWGSKKLAEEAAWKYVKENSPKYEVTSFAPLWCFGPQAYEAIAKESVPSTLSLVGHVLKKDNSLAQALLGSFSDVRDVAEGHVLTIESKEAAGKRLMLANGRFEHCHIVDLIRKNFPQLGIPEVEVIPYDKVGAPTVDCEATKKLLKLDNLISLEQSLVDSVNQFLETGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B012</accession>
    <name>G3B012_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pheromone-regulated membrane protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_102771</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B012"/>
    <dbReference type="GeneID" id="18245581"/>
    <dbReference type="KEGG" id="cten:18245581"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007078_1_0_1"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="9">
        <location>
            <begin position="280"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="10">
        <location>
            <begin position="550"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="706" mass="76788" checksum="6D4228AA309224EC" modified="2011-11-16" version="1">MDKEDVELQHLNFAQLNNEARNLINVHVPKSMQQPVMNHTVKYDGAHETSNDMMFNVPGGSSSETIRRDEEVEDKLHNGNDENHTLRSSKKERSDGMYAPNPDLFLRGDVQYDDRGEFIMLDNDSDSNIAPPTKVQAGVLSSLLKLYQNPEESKSTSSLTFGDTSTIHEFDNEDSKTSTGMTFNGLKEGIKHGGRKVYSIPFGKKAISNVALEGDGPGAEDVEGLPSFANARPKHHRKAASVNPADMPAKMSKRIRKAKRNQDRQLRITVHISDILQRQRFIMLMCKALMLFGAPTHRLEEYMTMTSRVLEIDGQFIYFPGCMIIAFGDAATRTSEVHLVKCSQGLNLAKLSETHKIYKGVIHDIMSVEEASSKLAKIFKSKNNFNPWLCVFFYGLGSGCVCPWAFGGGWIDVPIAFGVGLCVGYLQFFVSSKSNLYSSVFEVTSSIVVSFIARAIGSINGGDTFCFSAIVQGSLALILPGYIILCGSLELQSRNLVAGSVRMFYAIIYSLFLGFGITLGAALYGWVDKNATSETTCRAEHTVDDKWRILLVPAFTVCLALINQANFRQLPIMIVVASAGYVGTFFASKHFANVSEFTAAIGAFIIGVLGNLYSRIGKGLAVSAMLPGIFVQVPSGIASQSTLLAGVKAADQISGNSTTTSSSTGSGSLSFGVTMVEVSIGISVGLFAAALFIYPFGKKRTGLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B034</accession>
    <name>G3B034_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_133607</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684991.1">
        <property type="nucleotide sequence ID" value="XM_006684928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B034"/>
    <dbReference type="STRING" id="590646.G3B034"/>
    <dbReference type="GeneID" id="18249724"/>
    <dbReference type="KEGG" id="cten:18249724"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007367_1_0_1"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="203"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="766" mass="86820" checksum="C5BA66F658D6C4A1" modified="2011-11-16" version="1">MAMLSGRPSADASTSEATKKDLVLFRDVKAVKSGQIHRFQINYTPTTEDKVVSLTKNLWVKVKNTEPLPMRAAFIAGPYLLYVDCRSEDYDINKKCFITADQPTFEPQLQPGNSFYAELSCHTIKDTYRWTVDVVSQMIFNNNVEINFEIMVGTSRQVLHEASLPDKHVENRDRIGTFVSSQTLEVSDLDIYDLWNLPIPNPQKPIHLVILTHGLHSNVSADMFYLKEQIDSCNSDSASENFVVKGFFGNICKTERGIKYLGSRVAEYIIDLIQNNEPLSKGNVTKISFVGHSLGGLVQTFTIAYLQVNFPWFFQRIKPINFITIASPMLGASNENPIYVNLALSAGIVGKTGQELSLRFTEDVSKPLLLLLPQGPTHTVLKRFVRRTLYSNVANDGVVPLRTSALLYLDHEGLGTILSKKSMSSHNIDESKVDKIPDDDCVGDNNLSFLPQPVQVMLSKFMPQKQHKTTEVVDDKDEVDDPQSSNTKNILKRIEGLHRSSVLETAQSLLLPPLPPTSYIVNPDERENAIIYDKVYHEDDLPPRDSTEEASKRLGAEVVNVNEVKANDSQVTTFRKRLMSSFDLQEFERIEEEIAREYHKDMSWRKVLVRLNPDAHNNIIVRRRFANAYGWPVMEHLINNHFTIDAMKEQEAVSHRWNLNGIGMWDSETPGEGFELVDLLSRDLIKKENKDIEETGPKNDHQWINTKDNESFFSVGPASLISDVGEMVGNLRDQWYTNQNTRLAVQEEVEVCQPADEPPQVMGDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B046</accession>
    <name>G3B046_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_133616</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B046"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015712_0_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="631" mass="71891" checksum="911A2BAD0BDA4D2B" modified="2011-11-16" version="1">MITTFKSNTKNTPEVPSPFSCSICKRTFTRSENLKRHEKLHLHRKYVCPHCGRVYSRSDSLSAHAKKVHRLTVSSVKAIEGLQLSDSKSQTQDHLSILENLKSLDELKKTLEELRALKGLSVRQDLQSIPPEPANSPLQNTPPQLINDCLHQYWTKFDPCFPIVHRGSFVLPDSYDDDWLVNVMCAIGARYLPEHRHLSCQLYEYITNKSDPFPEHPQLQELQAILLVIYIGIYSGDNSWFKKSFRIYSRLVEFCRESGLFQFNPHDNCDKDWNSFVLTEGRKRFAYGLYLFDSQSAVLFNYPPSLSHYEIKHKLPCCESLWEATTGSEWQSRLHYSPLTQIPHFFKGLQEVLMFGSISGTISSFGAMILLSAVHIMVRNMAQYAGFHAGFKEMSSFHVQDAFTRRSQLGSALNCLRSLLPKKLEPHDIFDMWDEFSVTWNLAYIHLHLPDTVITSGVVEVTLNETIATASALARPQPKSPPGTALLSNDFSKSVYQVLSLTASHIAYFLETFMVDQLETSPVFTFMFYKAALVAWQILNAFKNVSLDGSKQEEKTPEELFGAPISNAQKDYMMKRLVDDMLSRIQSERYEDIRTGFFEKWVESVLESKSTWGVGGCAAASFTSLVSDPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0D3</accession>
    <name>G3B0D3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_92593</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0D3"/>
    <dbReference type="STRING" id="590646.G3B0D3"/>
    <dbReference type="GeneID" id="18250210"/>
    <dbReference type="KEGG" id="cten:18250210"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_3_1_1"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097308">
        <property type="term" value="P:cellular response to farnesol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000001">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000015">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="239"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="331"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="423"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="497"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="866"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1077"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV65371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1095" mass="120001" checksum="A7D3C5470652D161" modified="2011-11-16" version="1">MDSSELLKILDNPELFEKNHKQVREQLSIYLKSQESLVCDLRNDLETSKHANKAFKKALSEIGTVVISVAMGDLSKKVEIHTVESDPEILKVKITINTMMDQLQTFANEVTKVATEVASGKLGGQAKNEGSVGIWRSLTDNVNIMALNLTNQVREIADVTRAVARGDLSRKINVHAQGEILQLQMTINTMVDQLRKFAFEVAKVARDVGVLGILGGQAFIDKLEGIWKELTDNVNAMALNLTTQVRNIANVTTAVAKGDLSKKVTADCKGEILDLKLTINQMVDRLQNFATEVTTLSREVGTLGILGGQANVQDVEGAWKAVTENVNLMATNLTNQVRSIATVTTAVAHGDLSQKIGVHAQGEILQLKNTINKMVDSLQLFASEVSKVARDVGINGKLGIQAQVSDVDGLWKEITSNVNTMASNLTSQVRAFAQITAAATDGDFTRFITVEASGEMDALKTKINQMVLNLRESIQRNTAAREAAELANSAKSEFLANMSHEIRTPLNGIIGMTQLSLDTELTQYQREMVSIVHNLANSLLTIIDDILDISKIEANRMTVEQIDFSLRGTVFGALKTLAVKAIEKSLDLTYQCDSSFPDILIGDSFRLRQVILNLAGNAIKFTKEGRVSVSVKKSDKIVEETDKLLLEFCVSDTGIGIEKDKLGLIFDTFRQADGSTTRKFGGTGLGLSISKQLIHLMGGEIWVTSEYGCGSNFFFTVSVSPSGIRYTRQTEQLLPFSNHQILFVSTEHSDSELEVVGSSLIDLGLSPVIVRQITDANLTEPVNYDIIVIDSIEIAKNLRLLPEVKYIPLVLLHQSIPDLNMRICIDLGISAYGNTPCTISDLASTILPALESRSISQNTDESVCHKILLAEDNLVNQKLAVRILEKQGHRVEVVENGLEAYQAIQKKKYDVVLMDVQMPVMGGFEATEKIRQWEKKSNPIDSLSSRTPIIALTAHAMLGDREKSLAKGMDDYVSKPLKPKLLIQTINKCIHNTRQLKELSKQNNSNRTSSAFAKNLKNSGDLSRMNSNNSSSPATTPNGSHSNGPEPKIVEIFSSRPGSPKKANSNDYMLNGRPGQLQANNRSRTESAINVTSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0D4</accession>
    <name>G3B0D4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_119689</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0D4"/>
    <dbReference type="STRING" id="590646.G3B0D4"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="320" mass="36036" checksum="94D9224AB6AA12B4" modified="2011-11-16" version="1">MSHTADQEKLVLKVLSYKPHQFYEILEVSKSANDGEIKKSYRKLAIKLHPDKNPHPRAAEAFKIVNKAWSVLSDPDKKSIFDSTGADPDTRFNPSMSSASARTAGGASPFGGQSFGQPADFDDIFNIFFGGAPGGRRGGGQTFSFGNNGFTFQSFGGPGSGFQSFPRQRQSQRQSQPRADPEAATDLLTNLKQLLPILLFVLISVIPTLFAEPSVPDYSFTPSTKFNSQRTTPTLNIPFYVNDQFIQKKSYTDKQMKTFDYKIETSFIQDKRTKCSREQMIRNQLFEEAQGWFSTDQRKLERAQNYPMPNCEVLKQYNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0D9</accession>
    <name>G3B0D9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_97282</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0D9"/>
    <dbReference type="STRING" id="590646.G3B0D9"/>
    <dbReference type="GeneID" id="18250674"/>
    <dbReference type="KEGG" id="cten:18250674"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009031_5_0_1"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="203"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="622" mass="72000" checksum="E6B2C2B3CBF834B7" modified="2011-11-16" version="1">MLKKILQRYLLPIITFIFNHTPSFIWALVEFLLDVFFFWVKKIYSVYYSKDSLKEYLDQLKNVRTYNEWKKTVVEIDKITNLDLWRQNFISKHYDYVLIDERTKQLRRARINNDAPLLMSLLRGGLLRNFGGIAQKKLYLKSYMGTKFKIEEYIAEVLDCVNYLHDSLNSEKDTRNTEYIMNSKQLTLDFFHDARQSFGSTALILQGGSLFGLCHLGVVKALYFKGLLPRIFGGSAVGAAVASLVCCLTDDELIPILISIADVMGNVDRLNHDVDERYGNVLENVIKKGYSQEILLFLKFVRDTIGDLTFEEAYLKTEKILNIAIHPTDQSVPSLLNYITSPNVIIWTAIYASIGTGVLSDDVQLYVKDFNNKVVLQSPNLNVRFLKPQDVSYSQRYFSSSSSSRHSSKDDLSSETYSDSHYHLKAKSAYTRLTELFNVNHFITSLVRPYLAPLISNDLKHHTEYGRTKYHRVTNQVKEDLVADTDDQLQYKNDINEAYVKDSGFTVVKHMKNVFGMEVKHRLEVINKLGLLPDTIKRLVIDEKPSNPQSLASIREITIVPELRYLVKDFGRVFDVHKTMENIPYWVLVGERSVWPLFPLIWSRCAIEFALDDLYNIHRKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0T3</accession>
    <name>G3B0T3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_120801</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685602.1">
        <property type="nucleotide sequence ID" value="XM_006685539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0T3"/>
    <dbReference type="STRING" id="590646.G3B0T3"/>
    <dbReference type="GeneID" id="18248804"/>
    <dbReference type="KEGG" id="cten:18248804"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_0_1_1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="29"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="400" mass="44485" checksum="8C99AA2BB7531005" modified="2011-11-16" version="1">MSKFSHLELQPADEFNDLRIKLANDSDPNKIDVSAGVYRGEDGDSFTLPVVRKAKHLYHEENYGHDYTFCLGLPEFVQNAAKVAVGETAVSKKLVASCQTIGGTGACHLGALFLSQSSGYKNFYLGIPAWPNYFPLIKQAGGTVTTYSYYDTDNKCVDFDAMVTQLNTAPAKSVFILQLCCHNPTAADLTIEQWSQVAEIMKKRDLIPFFDAAYQGFASGSTETDGLPIQKFIELGCEVIVCQSFSKNLGLYGERLGCLHVVVSDASNTPLVSDQLRYLFRAECSSSPAYGARLMALITKSDELFAQWKKDLQDVSVRLRTIRDTVYKLITEKYKTPGTWEHVKTQRGLFWYSGLTEAQSKKLLEEYHVFLPKNGRVNVAGLNDNNIDAFCAAFDAVVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0W9</accession>
    <name>G3B0W9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_134130</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685634.1">
        <property type="nucleotide sequence ID" value="XM_006685571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0W9"/>
    <dbReference type="STRING" id="590646.G3B0W9"/>
    <dbReference type="GeneID" id="18249772"/>
    <dbReference type="KEGG" id="cten:18249772"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="348" mass="38285" checksum="F8DDB0FCFBC64D24" modified="2011-11-16" version="1">MTIPISVSPGSKVLVTGATGFIGAHCVQQLLDRGYEVKTAARSKNKFNTLKACFEEHHQSKLSFALVSDIGNYEQLVEAVKDCDGVLHLASPFSYTVTDMEAQLLKPAYDGTVTMLEASLTEPKVKRVIITSSFAAVYDASKGLQPDYVYTEKEFSPLTWEDGANTKDVSLAYRASKIVAEKAAWQFMEEKNPQFDLCVLCPTMVFGPLLSNQLFTTFEDLNLSNSVVWTIATSKEVPPTKGPLFVDVRDLAWAHVEALGSEAASNSRYLISAGDFDNQEIADILRESWSDKKLREGVPTGNPGHRLTGTHFKTDSSKAIAELGMTFRSLKESVLDLCDQLAEIHNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1D0</accession>
    <name>G3B1D0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113686</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1D0"/>
    <dbReference type="STRING" id="590646.G3B1D0"/>
    <dbReference type="GeneID" id="18247085"/>
    <dbReference type="KEGG" id="cten:18247085"/>
    <dbReference type="eggNOG" id="KOG1654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119276_0_1_1"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="135" mass="15757" checksum="7DFD4D9DD15D0924" modified="2011-11-16" version="1">MRSQFKDEYDFEKRKAEATRILERFSDRLPVICEKAENSDIQEIDKRKYLVPGDLSVGQFVYVIRKRIKLPSEKAIFIFINDILPPTAALMSTIYEEHKDEDGFLYVLYSGENTFGEGKMIPIDLSELDFSEFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1P5</accession>
    <name>G3B1P5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_120017</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1P5"/>
    <dbReference type="STRING" id="590646.G3B1P5"/>
    <dbReference type="eggNOG" id="KOG2260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:heat shock protein binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein stabilization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cdc37"/>
    </dbReference>
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        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="203"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="401"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="513" mass="58531" checksum="BA44CBB048E1537C" modified="2011-11-16" version="1">MAIDYSKWDKLELSDDSDVEVHPNVDKKSFIKWKQRDIHEKRQQRNQELKSILVQLTMYAKLNERVDSLLEALTPSQISDDAAVTKFLDEKFDKHEKFDYDALLKTKGDTLRKGLKDLTFDPAEFETTPPYNEMVEDLFVQIKEDHADAKDALKLVNYAKEHRARIDDLLSKQSIKLDDLLYQKSLLISSDDYHTGFDRSFLNKDEEERTPETKTVTSVETINSPGVTNTPPKKAEKTEKEVLEELQVMPETTEFSKIPLGDYVKSGAYLVKHPWICTEQQKDALIMTAFDHQLAGDSKAARQVIHQSLLLQYIAQLCGGGPNYNKDATVKAIKLFIGKINDPSVPVRTGFLQDYENTFNHIQNRCELIKQEQSQASDDDGEEGEALIQLRALDEGTELSVDIPPEGTPEYQLFTTELPLEMQEAVKTKSLDEVNKVFAKYKIEDAEQILEIINQCGVIGVSGYIEDEHEFEELQKQYNEQQIQEVEEEADDNADADSSVVHTETPNTEDIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1X7</accession>
    <name>G3B1X7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113323</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1X7"/>
    <dbReference type="STRING" id="590646.G3B1X7"/>
    <dbReference type="GeneID" id="18246899"/>
    <dbReference type="KEGG" id="cten:18246899"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014421_4_0_1"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39399" checksum="E94957B01B2C8C13" modified="2011-11-16" version="1">MGSAAINNRTYFPQALASGLASRVNKDSDSALITTTVPTTRNRRQVNYSEYDRGEDDFDDDFSPSSTSNQQSNNQSNESAVNKIILKPVRVPKYPSDLDSEENLKEVKNSDDVLVPIRLSIDYNGGNSKYQDCFMWNLNQTLISPEEFASIAATDLELPTSVHSVMVESIKKQIEEYKQYSNLQLPSNMEYHVIINLAVSLGKILYEDRFEWDLTQTDVSPEMFADIVVADMGLSLEFKPAIATSLHEVISRLKREIIEGKNHELEKYQQLSGLIFERGIRISTESSVNNGNDHWEPIVEILTPEEITRREVERQRSSRRKNRENLKGVSGKRKFDEVESSWRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B203</accession>
    <name>G3B203_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTEDRAFT_113337</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573</strain>
            <strain evidence="23">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B203"/>
    <dbReference type="STRING" id="590646.G3B203"/>
    <dbReference type="GeneID" id="18246909"/>
    <dbReference type="KEGG" id="cten:18246909"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 21" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 21" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV65031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="190" mass="21527" checksum="151F5C50F09513C6" modified="2011-11-16" version="1">MWIFEWFQDVLSSLGLWNKHAKLLFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGTVRFTTFDLGGHQQARRLWKDYFPEVNGIVFLVDAADPERFAESRSELESLFKIEELKDVPFLVLGNKIDSHSACPEMELKSALGLFSTTGKEGGKLPEGQRPIEVYMCSVVMRSGYGEGFKWLSQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B259</accession>
    <name>G3B259_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113381</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B259"/>
    <dbReference type="STRING" id="590646.G3B259"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="165" mass="18531" checksum="522AE43FECA42829" modified="2011-11-16" version="1">MQRKRATDQDDDEEMIDEEDAATEDAATEDVDMSSRTDINDYVGVSISVSFNSKYDEQQRIEQLSGGQKSLCAIALILAIQNCDPAPFYLFDEIDANLDTQYRTSVASMIHALSDRAQFICTTFRPEMLQVADKFYGVTFNNKVTTVSDITRNDATSFVEGQHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2P6</accession>
    <name>G3B2P6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_129937</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2P6"/>
    <dbReference type="STRING" id="590646.G3B2P6"/>
    <dbReference type="GeneID" id="18249411"/>
    <dbReference type="KEGG" id="cten:18249411"/>
    <dbReference type="eggNOG" id="KOG0294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031466_2_0_1"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="392" mass="44878" checksum="C6107DF36C72673D" modified="2011-11-16" version="1">MVKSARDRMWFRILVGSYEHNLLCLSLMLTEAQPVFQPVFHFEAHSLSIKSIDVAKRYLVTGSNDEHIRIYDLQKRKELGTLLSHQGTVTTLRFSDEHSASEIQESSEKSGKWLLSGSEDGKIIIWRTKDWEIFGTLKGHQDRINDLDIHPTGRVAISVSKDNTIRLWNLMTCKKAAILKVKGRDSLGQECQFVRWTKSGNHFIVGLMNKIFVYEAKDAKIHKQFGFKTTLMCMDVVTFEGAEWLVTGHSNGVLEFYDSKILVETEEEPRPVFSLRGHTNRIKDFSLYKVGTVPFLVSVSSDGKIVVWDLSESVRDQIAVYDTGERLNCVAVCPEAIEKAESMKRRYDPNEINDYSESEYETDGEEMRKVFNKASKKKRSKSSKSKVSITRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2V0</accession>
    <name>G3B2V0_CANTC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113546</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006685871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2V0"/>
    <dbReference type="STRING" id="590646.G3B2V0"/>
    <dbReference type="GeneID" id="18247013"/>
    <dbReference type="KEGG" id="cten:18247013"/>
    <dbReference type="eggNOG" id="ENOG502SBFU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836769_0_0_1"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="296" mass="33775" checksum="CEFAE3A24AFDCC55" modified="2011-11-16" version="1">MTDEIPEPAPYGGLLVQSIEDENDRAKRLAEQTVDVSVNGTSETLRPEAIHIRGVNSLSTKNIEAFINYYVNYVVTTENNEESGLPTTTYTPVSGDAQRKFRVQWINDGAVNIVFTTHEDATHALDQISITGANPAVVPMPVIYQVNLLVQERETKPYTPVIEFQKRTTLAHRLGVETETSEAQTSNMDEDESAVVLYARLSFQSDRKVKNAAVYSRYYLLHGEPERRPHKKRPINPKKRRHQRDYSDDLFADKLQARARPRGREEVEDLFADAMARIDRSRSPTRDRSRSPMRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3D8</accession>
    <name>G3B3D8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cora-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_122343</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3D8"/>
    <dbReference type="STRING" id="590646.G3B3D8"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_3_1_1"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="794" mass="89580" checksum="1C64EAAA5805EA9C" modified="2011-11-16" version="1">MGSHKQRNPYGDEYDKNDDASTTSSTNKDTDYSGAFIDHRLHNDLAHLHSSPSRARRRNSSIIGQKAPFSSYTEAATPLTDRNLRTWTHGNQPVAVAGTSPKTFRSIAIDMDKYTRDQSNYLQTPAQPMYHAYHDDPNTYDNGSINSMEFGESNPPSEHSGDSTSLDDVCFPDYYDDINETAAATWPDLKVLKDFISEEKSSLEDHHREPDQEVSPTDTHSEHVNFRLKSSPGRVEDDELGESRRPFQVTPTPIRPDEVAQLPGTRRPGVCRFTYFRDDLPNTIHAPTLSELLVNEKSMKVTEQPNLSQKWRDEDSREEVTNARIAAANGHGNGETVSQTPGTGTVSESVSGDSVTPFWLDVLDPTEEEMKVLSKTFGIHPLTTEDIFLGEAREKVELFKSYYFVSFMSFDIVYERRKQRSKEKEKKLSKLQELHERDNNGIMKRILRQIHGSSGNIGLATRSSSSNKSTGKKIREGELSPLSMYIIVFRHAVITFHFSPTPHPINVRRRARLLKDFLTVSSDWISYALIDDITDSFAPMIESIEDEVNAIEEAILRMHAGDSDSDSDSDSDDDEESRPPNVFVKRTRTKSTVDKSGMGLERSRTKSRTTTSGSRTKSSGSRVVAWKRKGDMLRRIGECRKRVMSLLRLLGSKADVIKGFTKRLNEVDSSRRPGAQESKSEISMYSGDIQDHIITMVQSLNHYEKLLARFHSNYLAQINIDMTKVNNDTNNVLGKITILGTIVLPINVVTGLWGMNCLVPGQGYDGLTWFWSIIGGMFMFSVFAYNYAKRAFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Z9</accession>
    <name>G3B3Z9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 105 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_121727</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686214.1">
        <property type="nucleotide sequence ID" value="XM_006686151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Z9"/>
    <dbReference type="STRING" id="590646.G3B3Z9"/>
    <dbReference type="GeneID" id="18248861"/>
    <dbReference type="KEGG" id="cten:18248861"/>
    <dbReference type="eggNOG" id="ENOG502QT25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043688_0_0_1"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42645" checksum="5D22D3552EF73E7F" modified="2011-11-16" version="1">MPAHLFDLKAKDVDSLVNILIDNLIHIKDETGKFLMTIPDGRIIDTKGWITGWEWTHGIGLYGMWHYYELTNKSQILKHIEDWFEAQMFGPDGSTSKNINTMAVFLSLAYVYERHGNERYVPYLDSWAEWAMYDLQKTKCGGFQHATYLTDNHEQMWDDTLMMTVMPLAKIGLLLNRPHYVEEAKKQMLLHIKYLCDAKTGLWYHGYTFDGNHNFANAFWARGNSWITIVIPEFIELLNLQPGDFLREFLIETLDSQVAQLAELQDAKTGLWHTLLDDETSYLESSAAAGFAYGILKGIRKKYLDPKYKSVAINAIKGVIGQIDGRGELLNTSFGTGMGDDLQFYRDIPLTSMPYGQAMAIMALVEFSRLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B428</accession>
    <name>G3B428_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase assembly factor FMC1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_105191</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686072.1">
        <property type="nucleotide sequence ID" value="XM_006686009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B428"/>
    <dbReference type="STRING" id="590646.G3B428"/>
    <dbReference type="GeneID" id="18245790"/>
    <dbReference type="KEGG" id="cten:18245790"/>
    <dbReference type="eggNOG" id="ENOG502SD6J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128881_1_0_1"/>
    <dbReference type="OrthoDB" id="4002732at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16213" checksum="91CDF8F822C3DCF1" modified="2011-11-16" version="1">MLPVYKNIIKELRVIAARSHKVHEKSNLAKNKAMLEYKKIQLIKQNRSIAEVDAQLKNLQVDLKPSAKFEEAFKQLFAEFSAENPNPTRIQQQHFKNVSDFLYGQRTYQELIERYNSGLGMDQSETVEKSANRVGFTVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B448</accession>
    <name>G3B448_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Thiol-specific antioxidant protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_105702</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Also involved in the correct composition of the hyphal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B448"/>
    <dbReference type="STRING" id="590646.G3B448"/>
    <dbReference type="GeneID" id="18245832"/>
    <dbReference type="KEGG" id="cten:18245832"/>
    <dbReference type="eggNOG" id="KOG0852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_1_1"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="14">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV63775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="193" mass="21528" checksum="FEDC0D8A4AA8DA98" modified="2011-11-16" version="1">MVAQIQKPAPSFKKTAVVDGVFEEISLEQYKGKWVLLAFIPLAFTFVCPTEIIAYSEAVKKFTEKDVEVLFSSTDSEYSLLAWTNVARKDGGLGKINIPLLADTNHTLSRDYGVLLEEEGVALRGIFLIDPKGILRQITINDLPVGRSVEESLRLVEAFQFTEKYGEVCPANWKPGEDTIDTANASKYFSKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4E3</accession>
    <name>G3B4E3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_105415</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4E3"/>
    <dbReference type="STRING" id="590646.G3B4E3"/>
    <dbReference type="GeneID" id="18245810"/>
    <dbReference type="KEGG" id="cten:18245810"/>
    <dbReference type="eggNOG" id="KOG1692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_0_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012565084" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="197" mass="22673" checksum="63DF19DB210A040C" modified="2011-11-16" version="1">MKLFAFLWLIGLALCHNVLLPPYGKQCFFETLKKNDELAISFQVGSRDPQNGEQLKASFYIGSPSGQVLVKKNDIDHGDEVVRATSDGKYTYCFSNERSSRVDMDVSFNVHGVIYIDFENPDSNTLDYAIQRLSQLTSDVKAEQGYLVIRERTHRNTAESTNSRVKWWSVFQILMVATNSLFQIYYLRRFFEVKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4K1</accession>
    <name>G3B4K1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_121880</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4K1"/>
    <dbReference type="STRING" id="590646.G3B4K1"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272804_0_0_1"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000206">
        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="206"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="650"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="689"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="808"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="950"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1097"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1156"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="650"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="818"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="965"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1101"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1188"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1218" mass="135482" checksum="11637847963A3A2F" modified="2011-11-16" version="1">MSITPNDQSSRSRQNSTLINKSVEPTTVVSSGGASHTALSPTTSVSQHSLSHHNTTTTPVPAPGSPYLSRKSSYASPTASYVSADPLSPHGDDKDLRHNIFGKVTGLLQKSLLSSGDSRSIISSTEYDCEPKKDVTHKISDSTLKLDTFPKVPMKGSMVSLSSSRRPSSKAFLSLPMSRTDSPVKETNRVFLEYDPFSKRKVLNTYEILGEIGRGEHGKVKLAKDLVNKDLVAIKIVNRKSKKERPQLRMRKSARTNIENEYELKIKREIAIMKKCNHKHIVQLKEVLDDINTHKIYMVLEYLEKGEVKWKRTTKNSSRDFDSPEIPCGGSGHKYDLETDLLSNDYAPNLTFRQSRKVFRDVLLGLEYLHLQGIVHRDIKPANLLVSSENTVKISDFGVSFASSLDEADEGLINELELAKTAGTPAFFAPELCQTNFSSSRNTSRESSFSHSRKDSKSNSSSSLEVLRNELTLTKVLPKIDYKIDIWALGVTFYCLLFGRLPFNAESEYELFQVIVNQQLEFPKDKDSFNCPVPITDSEFDLAKDILSKMLSKNSSKRIEIKDIKEHPFILLDLDNDLEALNELLYLNNPDSNNNFLSSIDLQAMSNQEDVTTEDLDNAIIGIGSRIKKSIVRAITSGTRDHEIRKRFLSGMENSSSFNSSSDESTPMSPAQLQQRLVGDHSVILSESQQYHQSSALSRSQTEAIHSNTSHSSTVNPSTLPTQATPSRSSSYTLAGIKDGRFSNPILNDVIEANKSDASSRRGSASAGGANEVETKRNVVGDLYFRNQSVVETFKGIQEMDDKRRRSSAFSASIASSNPPTAKNSVSSHPSLTHEISPSQPMNIPGAHVQIIVRPIGDANEHRASSVMSLPLTESFASLDSINDEYLTRKYKEFTKKKELEKSKEVEDTESTTDTLNEKFQNFNINNSMNSYGISFNFAKRDNKLDEIAPKTIVNSRPENSSDTGSEDDSGSESEEDGDLTLAFTSRVTPSKPKFLSLDQRAKSHDSSLPGLNRAKPTKRVIQMPVVFPHDHNTLEDVPAGLMARVPRPSVSIVPIDKSSVSSDPSPVQIIEPAPSNSIKFSPRVEQNEQLLSATQRVHNRKSDEHERRPSPLINNAPFSANATTNSHLYAFPRVNDSNEPPVFGKRHDERFNNHYKKEPISSPFPNAIHNDSDRESKHKSVQREENQTQSSNANRPDYYRSNSITIGLLQHDEPGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4K3</accession>
    <name>G3B4K3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LIP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114003</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686620.1">
        <property type="nucleotide sequence ID" value="XM_006686557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4K3"/>
    <dbReference type="GeneID" id="18247210"/>
    <dbReference type="KEGG" id="cten:18247210"/>
    <dbReference type="eggNOG" id="ENOG502S2P7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011938870" evidence="4">
        <location>
            <begin position="16"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="466" mass="50829" checksum="205832380DEF790C" modified="2011-11-16" version="1">MRLWALFLILSLAVAAPTTLKPPSEDDFYNPPDGYEDEELGTILKWRTPPARIRSIYFPVNVQNTWQMLVRSEDEYGNATAIVSTIFEPYNANSSRLVAYNVAEDASSIDCSPSYTFEGGGGIGTIIGKAEMILIQGALELGYYVVSTDYESSIGAFTAGPLSGISVLNTIKATLTTSNTTGINPDCEIVLWGYSGGTIPGGWAAAMQPSYYEELTGQLKGAALGGWVTNITATAEIIDGTIFAGLTPNAITGLAKQYPAINDAINEYITDKTENEDFNSAPDYCLLPSVLHYAYDQFFTGPDPWAKSGWSILSEERVKTVLNANTLGIDATKEYFPEIPMFVFHGRKDEVVPFKDAQRVYDVWCDAGIESFEFATSNSTGHILEVIEGSGAALKWISDIFNGVPPIKGCKQTSRSTNLLYPGAYKGYYEILTALIENVAGTKIGPSDSENVKRWLEPELKKRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B504</accession>
    <name>G3B504_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_122040</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686343.1">
        <property type="nucleotide sequence ID" value="XM_006686280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B504"/>
    <dbReference type="GeneID" id="18248877"/>
    <dbReference type="KEGG" id="cten:18248877"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000907">
        <property type="term" value="F:sulfonate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044273">
        <property type="term" value="P:sulfur compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="75"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="370" mass="41853" checksum="86A9BE56CA1F1E41" modified="2011-11-16" version="1">MSSAAAAVRKFQIQNNHITLSEEEIAKSNFKDFIPSWEQNKTYPPLEFFQHHDRGTFADPELPNLLPKDGDYTKKSITPKLGTEIDGVQLSQLTDEGKDELALLVAQRGLLVFRNQDFTDHGPKFAVEFGKYYGPLHIHPVSGAPIGYPELHIAYRNKDYANQGNYFKNKTNSIAWHTDVSYELQPPGITFFSVLEGPESGGDTAFADTIEAYERLSPEFKGILDGLYVEHSSVEQASFVENSGPIKSRRDPVKNIHPLIRVHPVTGKKILYVNPQFSRRIIGFKEEESKALLAFLYDHIANSHDLQARAHYEANTVVIWDNRRVVHTAVNDWDDTDATRIAVRITPQAERPIADLKDLNKEDKNRLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B532</accession>
    <name>G3B532_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_122928</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Utilization of purines as secondary nitrogen sources, when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B532"/>
    <dbReference type="STRING" id="590646.G3B532"/>
    <dbReference type="GeneID" id="18248934"/>
    <dbReference type="KEGG" id="cten:18248934"/>
    <dbReference type="eggNOG" id="KOG4145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038797_0_0_1"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000078">
        <property type="entry name" value="DAL2p Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="196"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="37133" checksum="2B4B8A375DB5E3B5" modified="2011-11-16" version="1">MVKVLTPEQFTQQVVLQYTDVIGEKLGGKVLEFSDEWFAAAENLIKPKPPIRDATRFTHAGAWYDGWETRRHNTAEADYVIFQMGVASAKLIGCEVDTAFFSGNHAPYISVEATTLSDGDDVKTAKWDSVIEKVECGASQRHFFARDHITADSYTHVRLRMYPDGGIARFRLYGTVLPILPKDLSTVVDTASVKNGGVAIKVSDQHFGSADNLLLPGRGHDMSDGWETTRSRQPGHVDWVVIKLGAITKVQEIIIDTAHFRGNFPQKINLKGLKASDGDDVSVESVGWRTLVEDSKTGPDKEHTFQVADGESCSHILLTIIPDGGVKRVRVLGTIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B543</accession>
    <name>G3B543_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 36, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_106443</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B543"/>
    <dbReference type="STRING" id="590646.G3B543"/>
    <dbReference type="GeneID" id="18245885"/>
    <dbReference type="KEGG" id="cten:18245885"/>
    <dbReference type="eggNOG" id="ENOG502SAUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_997550_0_0_1"/>
    <dbReference type="OrthoDB" id="4081130at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27815" checksum="69A8B027B47AE08D" modified="2011-11-16" version="1">MFGRSYSSIPPLRANKKKSEPRIRYLFYMFVLASLTVYFGAKRVDRKKIKTSFGSEKELDEYEQTTGIKRRTSLVSGNLAGKYKFYSVPYVEDNALVVKLQQALEPTKVKIIDPEVLIQQETEDNTRRYSFLLQDLKSKNKPLPSGLITALIRNEVSFYMNTSQGIYDTNFILKNYPRNTNEASKFETDVGYIEKVLVLKNEVLESLPKAVSDRDARSVNDVISYFETVGKADVVESLDDVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>G3B564</accession>
    <name>G3B564_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Plasma membrane ATPase</fullName>
            <ecNumber evidence="17">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_122984</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Cell membrane</location>
            <topology evidence="2 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="17"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B564"/>
    <dbReference type="STRING" id="590646.G3B564"/>
    <dbReference type="GeneID" id="18248939"/>
    <dbReference type="KEGG" id="cten:18248939"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000011">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="810"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="840"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="49"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV63149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="900" mass="98063" checksum="D2EC8AAF8F4A4F10" modified="2011-11-16" version="1">MSAATEPTKEKVDKALSDDEDEDIDQLIEDLQSVKAGLEESDDEVDEGSFKAVPDELLQTDPSTGLTADEVNKRRRKYGLNQLADESENMFVKFIMFFVGPIQFVMEAAAVLAAGLEDWVDFGVICGLLMLNAAVGFIQEYQAGSIVEELKKSLANTAFVIRDGSLVEVQSSEIVPGDILQLEDGTVIPADGRIVSEDCFLQVDQSAITGESMAVDKKHGDACYSSSTVKTGEAFMIVSATGDSTFVGRAAALVNKASAGTGHFTEVLNSIGTILLVLVIVTLLVVWTACFYRSVRIVQILRHTLAITIVGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLHEPYTVEGVEADDLMLTACLAASRKKKGLDAIDKAFLKSLISYPRAKNALTKYKVLEFQPFDPVSKKVTAIVESPEGERIVCVKGAPLFVLKTVEDDHPIPEDIHENYQNTVAEFASRGFRSLGVARKRGEGHWEILGIMPCMDPPRDDTAATVNEARSLGLRVKMLTGDAVGIAKETCRQLGLGTNIYDADRLGLSGGGDLAGSEIADFVENADGFAEVFPQHKYNAVEILQSRGYLVAMTGDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEIFLGLWIAILNDSLDINLIVFIAIFADVATLAIAYDNAPYDPKPVKWNTPRLWGMSIILGIILAVGTWITLTTMFMKKNGEIHGIIQNWGAIDGILFLQISLTENWLIFITRAQGPFWSSVPSWQLSGAVLIVDIIATMFTLFGWWSPRWTDIVTVVRTWIWSFGVFCVMGGAYYLMSESSAFDDFCNRRKTKPTHDSRAFEDFLVSMQRVSTQHEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B565</accession>
    <name>G3B565_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_106978</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B565"/>
    <dbReference type="STRING" id="590646.G3B565"/>
    <dbReference type="GeneID" id="18245928"/>
    <dbReference type="KEGG" id="cten:18245928"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_3_1_1"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="807"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="852"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="892" mass="102270" checksum="CA3A1436AB5437A1" modified="2011-11-16" version="1">MKLKRSKTVAFHEITPEYPDTAYQNTYYHQDEYNPNPYDYNYDMRMMPTRQLTFNGDNYMTNQLRDVDDDGDLDPFGDEESLFSEMSNEVNRQKSIRVKAGDLLDEDEDDLDDYKPKLNYSKTLKRARLVNGNYVVDCSVPKTLLETYGKKITDGGKEMSLLRYSACTCGPSNFSAFKYSLRQDMYTPKRDTEIMCVITMYNEDEILLARTLKGVFNNISNLTNRNHPDWGEDSWKKVVITIVTDGRSALNERTEKLLSALGIYQDTYAKSKINNKSVKAHVFEYTSTVGIETINENRIHLTVNDNPVQFIFCLKEKNLRKINSHRWCFQAFAPILQPKVVMLLDCGTVPQKDAFFHLWRSFNDPNVAGACGEMKTGLGPNKSLLLNPLVAAQNFEYKISNVLDKPMESVFGFISVLPGAFSAYRYEALLNVNGKGPLEKYFKGEFLHHSNKIDENDDDDEKELKEKSYREVGIFTSNMYLAEDRILCFELVAKKGCNYILRYVNEAKAETDVPETIEDFVLQRRRWLNGSLFAACYSIFHWTKIWKSQHSLLRKLVLQVEFYYQLVTILVSWFSLASFFLVFDILTSNLGSKTIDFEVGKYLSIVALWLYVVAIICTFVLGFGNTPRGTKKFYLAISITFAVLMLYMLFAAVYLAVSTVNSILKNNHFTALMLVSNEKFRDLVISMASTYVLYFVAALIYGEPSFMATSFLQYLLLSPTYVNVLNIYSFCNINDISWGTRSDPQARDLGQAKSTGEKDGDVLMMVSGGDELEVNDKYMNTLEELRVVPDKVEKINARKDKDDNYYALIRTITVLVWVFSNLILIAIVLEIGGMSQVMQVTSYTMISNNSEVFLSIILWLVAGLALYRFIGSVLFLVFKVFRPLKWKIRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B599</accession>
    <name>G3B599_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114488</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B599"/>
    <dbReference type="eggNOG" id="ENOG502RPUT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715708_0_0_1"/>
    <dbReference type="OrthoDB" id="4005225at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="417" mass="49346" checksum="C1EA4FCB6279C44B" modified="2011-11-16" version="1">MKTRLTFNIKLIRSIITQYRQSHNRPQNDRSIIDEALNLFAPKQAPKNTSNYKPSILSSVAYGPVSEQYQTKITREPQDVDAFKVRTDFSTGRLVNFLDVVSLPRDMLDLNNKILKSTDSEFRQIIGEIRDQEQLVYIFKFLYLQDKLNLSKLTTIVLNKNLRNLSLLPFDLKHPEDSMLNWPALDYTKLRVTLLRKFQTMHKPLHIVKNLEQSFDHDYLPSMRSKELPQFYERTIWKYYFEYVSHMNKHKDESYFIHELNDLYHSFTIWESSKLKSLPISTEILKVHKSMNRLQQLFFKICSQESVNRLINSQLQKNKYSDLLNVLKKISINYKFYSFGELEDTSIETRATYYMVIDSLEKLLVHKIVPFAKGEDVSELVSELNEIKKIITKFEASDDIHENNWDDKLVLLSSFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5E0</accession>
    <name>G3B5E0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Mitochondrial respiratory chain complexes assembly protein RCA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_106846</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of the 850 kDa m-AAA protease complex, a heterohexamer composed of YTA12/RCA1 and YTA10/AFG3. Associates with the prohibitin complex, composed of PHB1 and PHB2, inhibiting the activity of the m-AAA protease complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5E0"/>
    <dbReference type="STRING" id="590646.G3B5E0"/>
    <dbReference type="MEROPS" id="M41.003"/>
    <dbReference type="GeneID" id="18245920"/>
    <dbReference type="KEGG" id="cten:18245920"/>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_23_0_1"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097002">
        <property type="term" value="C:mitochondrial inner boundary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF14">
        <property type="entry name" value="MITOCHONDRIAL RESPIRATORY CHAIN COMPLEXES ASSEMBLY PROTEIN YTA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="406"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="816"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV63195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="845" mass="95039" checksum="CA06D64AED6914CA" modified="2011-11-16" version="1">MDTFFRECDNFKNAKLTPPDVLLDNLVAEFKEAHPEVTPLTREDILYYYHICYDLSNGYTFLQDIKIEDSKVQLMLYSFLDVEDFEDLSSPISSVAQELSLSEDLVTNWFDIFKLLMDIPFPKEGEVNRCPISPREYNGFQIGIEAVSEQINDTVEKLSLGNFFNRESGNKEGSTKSSSPNNNSTSEKQQNNKKKDNNKPPFAFEIDLTPGRLFNIGFVVVVLGYLWARVYSERFVEVTFQKFTTDFLEKGLVSRLLVVNNKTVTIVLHDSAKGERSAEYYFTIGSVESFENALKQVQDQLNIDQSARIPVVYTTSGSTAKFLINFVPTILLLSIIYYMGKRASNMGGMGGPLGFAKSNAKKFNQETDIKVRFKDVAGMNEAKEEVMEFVKFLKSPEKYEKLGAKIPRGAILSGPPGTGKTLLAKATAGEADVPFYSVSGSEFVEMFVGVGASRVRDLFKMARENAPSIVFVDEIDAIGKARTKGNANGANDERETTLNQLLVEMDGFDTSDHVVVLAGTNRVDILDKALTRPGRFDRHITIDNPELSDRKDIFDVHLKKIKLRENVDHDLSGRLAALTPGFSGADIANVCNEAALIAARYNQTSVDLKHFELAIERVIGGIEKKSKVLLPEEKKIVAYHEAGHAICGWYLRYANPLLKVSIVPRGQGTLGYAQYLPPDQYLLNTKQLVDRMIMTLGGRVSEELFFKSVTGGAHDDFKKVTQIAQSMVLRYGMSPAIGMVNYADTRSQDNLTKPFSDETNKIIDEEIERIVSECYEKCRDLLQERRTEVELVASELLRKEFITRQDMIRLLGKRPFPENNDAFDKYLDSKPPYQDLQQPDEPANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5G0</accession>
    <name>G3B5G0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_135048</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5G0"/>
    <dbReference type="STRING" id="590646.G3B5G0"/>
    <dbReference type="eggNOG" id="ENOG502QR4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_416171_0_0_1"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF6">
        <property type="entry name" value="TRANSCRIPTION FACTOR SEF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="604" mass="70602" checksum="13AD6302FCA1488E" modified="2011-11-16" version="1">MITKMEKISKGKVTKSCARCRKHKTRCDSIIRNPLPCSSCAKRNLECFLDIISSNPKRTSNDVLEKLDMEVNSLKESVDHLIYKKSILINLLIKQNPSISEIQNCLELDDYDIKDEELSSSSGDFSISSDVSVAPVSLTKDEVTFHFDNYFKNYHRFLPILPDSLYKEANVNQIYDESKLLFWCIVLTSHLNTDNSKQYLNLSKHVKKLVVEMCWLNTPRSVYVLCSLLVLTTWPIPLSPKEKMNDNLSIKYLSLMRNLSLQLGLHRLEFINEFSHKTNMTITKEINMNNLIRERIYKFITVNSNYWLINLGLLHLNFNGFQEDYVINKATSMNQNTADISEEDRYINSLLKVSIVQQRLHENLNNNNQMQSKLISLNMFEVILNDLKKDTSAISKDNLIELSVEYSKLQLYLYSLDSSLKLSLNDYRVFIYKTLTSCYRVIDLFTNEFPNLYSINQLPIHYKFIVELVSLILERIFYTPLLKSVEDYEILKSKFKTIHLLITKNNESNWNFFNSRLLKIIAKYNEILGHNLLGFIKDSKSLYILTKFNTHQVANMNYEMTWSIYSSTKGKTNFNDFNDREITWDAFGIKDKQLIEYLDNISLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5X5</accession>
    <name>G3B5X5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114622</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687121.1">
        <property type="nucleotide sequence ID" value="XM_006687058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5X5"/>
    <dbReference type="STRING" id="590646.G3B5X5"/>
    <dbReference type="GeneID" id="18247512"/>
    <dbReference type="KEGG" id="cten:18247512"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_35_0_1"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="301" mass="34220" checksum="17D175DB425FC699" modified="2011-11-16" version="1">MSTTTFKTTKLSNGVEIFYRESGCKSKPILLLLHGFPSSSRQYAQIIPLLNDKFHIIAPDLPAFGQTKLPEDFNLSFDALAETVSLLLDELKITKFSVYVFDYGAPVGFRLALDPKYEVSSIISQNGNAYEDALQEFWDPLRIVWELVEKPSLTPKESSQLESINAELTKLFLTYEPYHSQYFDGEEDLSRVDPEGPVVDFQLLSEYPNTTHNQLTLFTDYRNNVKKYPVFHQYFRTSNVPILVIWGVNDFIFPKAGQEAFKRDSKNVKLVDIPGGHFAGISHAPEVAENIVAFAKEYNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5X7</accession>
    <name>G3B5X7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-alpha-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114625</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5X7"/>
    <dbReference type="STRING" id="590646.G3B5X7"/>
    <dbReference type="GeneID" id="18247513"/>
    <dbReference type="KEGG" id="cten:18247513"/>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014184_0_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="113"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="260"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="355"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="438" mass="49090" checksum="882FFFD6360F29C6" modified="2011-11-16" version="1">MGACVSKSSDAPAGSGAQSKVNTNLKASGQSHTNTTIARTRQSEAVSGPVVIPATKEHNNSSDSSNDDSTRYNEKNQLGNSESAGSGLPTGNNNQAGNQLNKEVKVLLLGSGESGKSTIVKQMKILHQNGYSKEELLEYKPFVYKNVMDCIKSIINAIVDLEPQLIRKVEDASEKDKDDTLLSYNDLNDILDYEVNINSKDPFNEQIALKINKAYSNPKVKEFIKYHSADFYLIDSSNYFLSDIMRITKKNYIPTTNDILRTRKKTSGIYDFRFSMGPGLPIHMYDVGGQRSERKKWIHCFDNVTLIIFCVALSEYDQVLLEENSQNRLEESLTLFDSVVNSRWFARTSIVLFLNKIDVFAEKLPYSPLENYFPDYSGGNNINKAAKYILWRFTQVSRSGLNIYPHVTQATDTSNIELVFAAVKETILENSLKDSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6I5</accession>
    <name>G3B6I5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_94223</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687270.1">
        <property type="nucleotide sequence ID" value="XM_006687207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6I5"/>
    <dbReference type="STRING" id="590646.G3B6I5"/>
    <dbReference type="GeneID" id="18250372"/>
    <dbReference type="KEGG" id="cten:18250372"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="162"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="578" mass="65815" checksum="3277F6EAD537E558" modified="2011-11-16" version="1">MLKLSLARAGKSVFHKSPLRTRGADIVQGLKFSSSKAFPRHRTKFPTPLKVTGGLGITGAVLYFTNQIFHDTTKNTISICERVGVVTVATFRCFKLYKDALDAEYHTPRDRELALKRTHKRAAYITLKALETNGGIFIKLGQHITALTYLLPEEWTSTMIPLQDRCPQSTIEEIREMFKSDLDVSLDEMFSDFSVEPVGVASLAQVHMATLRNTGQKVAVKVQHPSLKKFVPLDVKLTQLVFALMYKVFPEYPLTWLGDEMQSSIFVELDFTNEARNAQRTDEFFKNRRSITALRIPQIVSANKRILIMECVIGSRLDNIQYLKTNKIDPAEVSSCLSHIFNSMIFEPGASLHCDPHGGNLAIRALPKTQSKNGHNFEIVLYDHGLYRDIPLEMKRDYSHFWLAVLDKNVPEMKKYAEKFAGIEGEQKFKIFLSAITGRDPNTAMNYDISSRRTEQESASIQTQLHSTEGALEDLMSILSHMPKIVLLILKTNDLTRHLDEDLKSPLGPERTFLILARYCAETVYLEAKAQIPLSTKKYSLGWLSQTISAWWSYQKRLNSLLVYDVYMMFANFRKSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6L7</accession>
    <name>G3B6L7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114802</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6L7"/>
    <dbReference type="HOGENOM" id="CLU_3032168_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="55" mass="6169" checksum="DB4E17250C526D70" modified="2011-11-16" version="1">MGVSGMSGVSGKYYHDAPHVKLRGKISKLISWSRRTRQLQAELMKANSDTFFGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6M5</accession>
    <name>G3B6M5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114289</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6M5"/>
    <dbReference type="STRING" id="590646.G3B6M5"/>
    <dbReference type="eggNOG" id="ENOG502S791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106738_1_0_1"/>
    <dbReference type="OrthoDB" id="2148716at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="149" mass="16623" checksum="AECEF6A7C0B1042D" modified="2011-11-16" version="1">MSSSILSEREAIIDTVYRATLGIDTNDAQLFGSACLQNEELTFVMGDVVVNGWEPFFGYTSGHLFTVTTTHYLTSPRVEFKEEGAAQLTVQCVAYHIKPENAFKEDNKAYINASSQTLDVFKVGDGVWKIKKWNISKNWSSGSPANVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Q5</accession>
    <name>G3B6Q5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114304</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Q5"/>
    <dbReference type="GeneID" id="18247364"/>
    <dbReference type="KEGG" id="cten:18247364"/>
    <dbReference type="HOGENOM" id="CLU_1626811_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="1">
        <location>
            <begin position="39"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="163" mass="18409" checksum="EAA9299FCC341AC4" modified="2011-11-16" version="1">MGLLGKVQRAKVITKSMVTGFTSNNLFKRSVMFVIEDGKSEPDPQRTQELISYTYNDQGLFGVCECLQEYLDYRGSDWSRVYKAIIVFEQIAIRGSENALMFTENIDTKFKELEAYSGAGKDSINAAAKRLYDFLQDEDLIAETRKNVQPSGVVFTGGQIYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B720</accession>
    <name>G3B720_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114386</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B720"/>
    <dbReference type="STRING" id="590646.G3B720"/>
    <dbReference type="GeneID" id="90982234"/>
    <dbReference type="KEGG" id="cten:90982234"/>
    <dbReference type="eggNOG" id="ENOG502S5GM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120591_0_0_1"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF1">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="20593" checksum="8F532828D71C2E55" modified="2011-11-16" version="1">MEDLFDKQIDPRLSHLPQLSEFFQYVTVSKLLNPAFIQKLNSMFVTNDDGYEYKLELVVENQRGLKIFGIPMFSSNSLIPMLDPSSFQLLNGQNLKVIDNNLNNLPLPDLNWQWHWECWYVLMLNDVDDQGWIYSKINFNSHHWKGKYYFGNFIRRRVWIRLRHRSLSEMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7H0</accession>
    <name>G3B7H0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial distribution and morphology protein family 31/32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_131645</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7H0"/>
    <dbReference type="GeneID" id="18249547"/>
    <dbReference type="KEGG" id="cten:18249547"/>
    <dbReference type="eggNOG" id="ENOG502QQJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016236_2_1_1"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="524" mass="59887" checksum="75477A499F145D01" modified="2011-11-16" version="1">MGERGAIGAGAMSAWCWAGVSSAFLHQRNLSPKEQLLKNANNWVSRIRIRAKWLLKRSNRPFNTDDYSAFFSWLVISNALLIILATTTFFSLLIFTINTVFAQEFVARQLGEFITKNSKLSVVFENAIVPGWKDGKISFQKVSVSRRPKKSRKFIKGTSTAEQALLDDVVEYDDGNYTQYDLTIEQVNMTLSFNKWVNGHGIIDTLEMHGVRGVIDRTHVVWDPSDSATNYKNVYHPGDFEIDNFKIDDMLVTLYQPDGFRPFNVEIYNMSTPRLRKHWLFYDLLNSDLVNGSYDGSLFTIHKRQRVDEIDTVLAEALGGGGKDTSILNESNFRLQCCRINSLNLDHLNRGLEGPFGWITNGKVDMIGDFVIPINPPDDILSYLRTLKDNKNRYHDKLKSQDPDPRILLNLSIKLNNVRASVPFQTPELSYINYALIRPIVAYINSKNTYIELHNQIVKTLSDFEGSWTVYDSLLMDDISIEVYNNFVNYVADEESRLVRMKKVSFWSAQLLLQLLLLTIGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7K5</accession>
    <name>G3B7K5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_124576</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7K5"/>
    <dbReference type="STRING" id="590646.G3B7K5"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_3_1"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="116"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="207"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="294" mass="32343" checksum="A207461E45E6016A" modified="2011-11-16" version="1">MPHERKDHLQQGADVSPYKSLVAGSISGAVARAITAPLDTVKIRLQLQTAPLKDYLGVSHTFKNIVRNEGVIGLWKGNVPAEIMYILYGATQFTSYSILNKALTQAQDNVPILRFSRPTHSLIVGAGAGVSSTLITYPFDLLRTRLAANSSKELLSMARSIRQIGRHDGFSGFFLGIRPALLSVASNTGLMFWTYELARQYSKTYNTIPFIEGICGFFAGAAAKSITFPLDTIRKRMQMKRFSVGANTISSIRDILLREGIFGLYKGFGISIFKTAPTSALSIYVYEYSLSVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7K7</accession>
    <name>G3B7K7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115100</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7K7"/>
    <dbReference type="GeneID" id="18247718"/>
    <dbReference type="KEGG" id="cten:18247718"/>
    <dbReference type="eggNOG" id="ENOG502RQ0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923038_0_0_1"/>
    <dbReference type="OrthoDB" id="4087010at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="302" mass="34011" checksum="0752AE3680CEEA7B" modified="2011-11-16" version="1" fragment="single">MAELISNKSVYSRDEFNWESNKMKLMNEVDNIILSFNLSPYQDLTKPPIKNTKTSSTKAASAAPIVAQEPPPRPPPIPLTQEPFKQKIEMPKLSKTQRRMSLDLMQTRPQSTTNPFIIHTRTNSLSKPALTSTSTVNVLTKAEIGKLQDNPPPQKVNDPRKFNLTSIIPKRRVAKEPVSNTTNTEVTLSAVDKRNRRASLVGENLPTYIKDQLSLVGGNKKQLNKKQSRLQNLLSNSESLYVHNKDSSSLKSDTRTGTSDYNTSNHTESDDDKEYVSPNSLTRYYEDNDEDEDEVDFVNVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7M9</accession>
    <name>G3B7M9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_115112</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7M9"/>
    <dbReference type="STRING" id="590646.G3B7M9"/>
    <dbReference type="eggNOG" id="KOG3507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179456_0_0_1"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00615">
        <property type="entry name" value="RNApol_arch_Rpo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023464">
        <property type="entry name" value="Rpo12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="73" mass="8053" checksum="04212E234518E4F0" modified="2011-11-16" version="1">MSSPQREGFTAPSSISHAAQGYVASKSLGVKYYCAQCGSSFSLNKSDAIRCKDCGHRVIYKARTRKMVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7S0</accession>
    <name>G3B7S0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_115772</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688476.1">
        <property type="nucleotide sequence ID" value="XM_006688413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7S0"/>
    <dbReference type="STRING" id="590646.G3B7S0"/>
    <dbReference type="GeneID" id="18248006"/>
    <dbReference type="KEGG" id="cten:18248006"/>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026244_1_2_1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="15">
        <location>
            <begin position="55"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="419"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="256"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV62306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="454" mass="52230" checksum="41A4C9562377F037" modified="2011-11-16" version="1">MASTKVDIARQVPSAPPADEPAARLLPGEHTLPASWWTSEKVFELEKRSIFNKSWLFCIHSSRFNKAGDYFRFTFAGINFFVIKSKVDNQIKAFHNVCRHRAYPVVRKDKGSSTVLGCKYHGWSYNSDGKLLKAPHFNDVEGFVKEENSLFPVNTHVTEQGLVFVNFNNDPESVIPFDKWFEGLNSELNEFDFSDYEYHMSYELDGQFNWKTLMDGYQECYHCPTAHPGLSSAFKMETYKVVPKNRYCRHYAQIVREEQPESEPEPEPEQSSWFGMRKQAQPQPSPQKKPKKANPGGEFNGLWVYLFPTNGINCYSPAWYSIRVLPVSPTHTILQYDIFTKKGLDEDTKKEFVDFLQLVELEDFNLCQLTQKNLNEGVYSSGYLHPLKERGVLFYQNLVRDMVKEHFALEQAAGKPINPAIISNKKANKDVQELEEICNQLECGSSSGSSELQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7T8</accession>
    <name>G3B7T8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136245</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7T8"/>
    <dbReference type="GeneID" id="18249955"/>
    <dbReference type="KEGG" id="cten:18249955"/>
    <dbReference type="eggNOG" id="ENOG502RQ9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1019406_0_0_1"/>
    <dbReference type="OrthoDB" id="4096449at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="273" mass="32994" checksum="87B5D066B76A2ED4" modified="2011-11-16" version="1">MASIFHNIRSGKPDDISLINYEELEQKFHIHKYYPKYFHNEQASTPDIKDLLFDKPIYSKANEHVKNWVNPGIRQTYETELDLDSGKLHIRKENVEQQNQNLGDLKQERKQLREDHRQERKQLHEEQKQERRNLREERRGSRVDQPDPKKDKRREKLENKWLMKERLRLIESKQKRDDPVMFKNPWGNQESLEMYINTQHNPETERKNSVTSRLISLMSNTSDDLKLTKTNSFDQTKSALTSNRKKSLFRKRYSEQLGTYTTKHSRKEREETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7U2</accession>
    <name>G3B7U2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2433 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_131682</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688491.1">
        <property type="nucleotide sequence ID" value="XM_006688428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7U2"/>
    <dbReference type="GeneID" id="18249553"/>
    <dbReference type="KEGG" id="cten:18249553"/>
    <dbReference type="eggNOG" id="ENOG502QSJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_532076_0_0_1"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="243"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="473" mass="54274" checksum="B7A1A7B7C5A67345" modified="2011-11-16" version="1">MKVTLLADVQGNWDEVNELQTEPDEVIIHSGNFGFWDSDTILNCDFNYLKQLISFSSILDKDMIDDINDKININQVPNQEVIEDIKQKIVGQYDYLDDYISGKKSFRVPIYTIFGPMDDPVLVEKLVNGTIQIKNLNLIDHTKGYSIQSPGQPDIKIYGLSGRFKFLNLFNSGDYTNKINGKFGELWMTLLQISEFYQLNSNSLNSINIFVTYNSVMKNPILEYLAMVTNANFTVSQGLHFKFPIIGNEMSFLNSIENFKLKFSKFRIKFGELFKLIKGDLMELDGDTSKSLETALEILDVIPIIHTNQIIPLTLKDTDVKPDNGILEGYETSKNGHKTSKDYDTNAMLNKINELYFENFYNLWHFNLCDFKIGDEKNVINLDYANGKVNLHHCYSSGFDFNFKTDQKDLGDEDVDHLIETNDIEEDLEDDDFDGFQLPTRGRGKGRGRGRGRARGRGRSRARGRVRGKFRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B811</accession>
    <name>G3B811_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_95213</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy; may act as an adapter for ATG8 that supports mitophagosome assembly. Negatively regulates the proteolytic processing of ATG32 via the i-AAA protease. Acts as a negative regulator of the m-AAA protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. The mitochondrial prohibitin complex interacts with the m-AAA protease, a heterohexamer composed of YTA12/RCA1 and YTA10/AFG3. The mitochondrial prohibitin complex interacts with ATG8 and the interaction may support mitophagosome assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B811"/>
    <dbReference type="STRING" id="590646.G3B811"/>
    <dbReference type="GeneID" id="18250489"/>
    <dbReference type="KEGG" id="cten:18250489"/>
    <dbReference type="eggNOG" id="KOG3083">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_0_0_1"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00057247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00063239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="276" mass="30440" checksum="C42DAAF925884628" modified="2011-11-16" version="1">MSSRLSDIFSKIAISLGVTITLAQSALYDVEGGKRAVIFDRLNGVKQGVVGEGTYFLIPWLQKAIVYDVRTRPKTIATTTGSKDLQNVSLTLRVLHRPEVMSLPKIYQSLGLDYDERVLPAIGNEILKSIVAQFDAAELITQREVVSARIRQELSKRAEEFNIKLEDVSITHMTFGKEFTKAVEQKQIAQQDAERSKYLVEKAEQEKKASVIRAEGEAESAETVSKALSKSGDGLLMIRRLEASKEIATLLANSPNVSYLPSGQGSENNLLLNVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8J0</accession>
    <name>G3B8J0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_98894</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8J0"/>
    <dbReference type="STRING" id="590646.G3B8J0"/>
    <dbReference type="GeneID" id="18250811"/>
    <dbReference type="KEGG" id="cten:18250811"/>
    <dbReference type="eggNOG" id="KOG2485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_0_1_1"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="129"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="369" mass="42344" checksum="2B65A6200CD0C9D4" modified="2011-11-16" version="1">MSFVPRRIFPGFNITLANFKGHHQKALTKFGHLAPQIDYILEVRDSRAPIATTNVLLERVLARKPKVVLYSKKDLSVLSTPLLEKWHNKHNEEYMVIDARSKQDAKRIIDRMTKEYNKMNPPPPLGMRLMIVGMPNVGKSTLVNTLREVGYNYHLTDTISTKRRKVAKTGGQPGVTRNTSEIIKISQWPEISVHDTPGVFLPTVKNSETMLSLALVGCVNSSFVDPVIQADYLLYLLNLQDEPGARYSEYMDHPTNSVDELLFNIAKTRNKLKKDDSYDELGMANHWLNLWRQAKGKQYRGLFELETIIEVGGKQVRSMFEEEKERVRSMNVHQKIVDSLGEDGTGMSKKRSRTAKDREFDIRNRLFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B904</accession>
    <name>G3B904_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115264</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B904"/>
    <dbReference type="STRING" id="590646.G3B904"/>
    <dbReference type="GeneID" id="18247796"/>
    <dbReference type="KEGG" id="cten:18247796"/>
    <dbReference type="eggNOG" id="KOG0007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013259_0_1_1"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="378" mass="42973" checksum="66504DA954384F9A" modified="2011-11-16" version="1" fragment="single">MTGDGIPEDITVPPPDVRAVIDKTAEYVLKNGDSFETRLKANADSTTKFPFMFSTDAHYPYYQWKLGRHQVETKTPASTTSTKKLPEPPPLEFLSELPTVSPYDLTIIKLTALFVAHNGDKYQQELSHHQISRGNKAQFEFMNTSHSLYPVFQVFLHQYKRTIEVLLQNSSFVPLLPDSYHRAKHSKLNQVQHDTQKKERLARQTRYASVDWQDFTIVGKIEFDDIDKVTELAMPLKREDLIYRSLEAKAKAIEMPPVAVPATAGPDPELEAVSTVPKGMKVKSAGESRLKRKDKEPTIKCPITGKAIAESAFDEHIRILLRDPNYEQQKKNYIDKNFRYGSNLTNDEVYQNIKRLSRKRGSAPVPGTTVKRVGPSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B906</accession>
    <name>G3B906_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_125017</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B906"/>
    <dbReference type="STRING" id="590646.G3B906"/>
    <dbReference type="GeneID" id="18249070"/>
    <dbReference type="KEGG" id="cten:18249070"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="176"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="370" mass="42535" checksum="D017F0F45D1D6755" modified="2011-11-16" version="1">MNSVKVLFSSIDNFIPNQDPPADPPADEASAELSQIYEDNEGENEAESRDLSESESPDPHNPSASDVSSVHKLGEEDESLNPHYSLHVLFQLLLRLPHLVVIKPLAFFWRLLLHPFSLILKSVDFDYAYHVDVQEKMDLIKHENILSNSIKSPTASSKYILPPPQRLFPLVRNPGKARRRKTLILDLDETLIHSLSKGSPRSLSGHDSNIIEIKLNSVATLYHVHRRPYCDYFLKEISKWFDLHIFTASVREYADPIIDWLENEAASDEKIFKKRYYRNDCTYRNGVGYIKDLTKFFPVEDLKNVIILDNSPVSYALNEDNGVMIEGWINDQNDKDLLNLLPMLHSLSLCIDVRFILGLRQGEKVFESYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B942</accession>
    <name>G3B942_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF171-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115920</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689102.1">
        <property type="nucleotide sequence ID" value="XM_006689039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B942"/>
    <dbReference type="STRING" id="590646.G3B942"/>
    <dbReference type="GeneID" id="18248081"/>
    <dbReference type="KEGG" id="cten:18248081"/>
    <dbReference type="eggNOG" id="KOG3925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061859_0_0_1"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="358" mass="40433" checksum="2F3271667B1AAC21" modified="2011-11-16" version="1">MAKRKAEIVNKPTKKPHKSSPEVQFSICLPSSLISYANASNLEQITNIAYQVAKAATIYNVPEIIILDVPTIDAQYEILESKANKAVKIDKKIKFNEILEPPVQQQIVPNQPQNVQENHNNHELFESLLQFFITPPYLVKAMLKDNKYTKKFKYAQTLPKLSTLPFMGNNGTHNDFKEGLSIPKKSPGNKKQRNKLKVTKYVNIGHAQPFELTQEVPVNVRVTVDLKNKTIVSPLHAYGVIGYKSSFGYHTRIARNFNEIFTKSAFPTGYTSSIYVNCANYFSSEPADTTNNIQLNSSENNRVLLVFGNPKDLEFSFKQDKSLSVPSFTDLFDQKLCIPPTIKVEDAVLIALTKLYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9M6</accession>
    <name>G3B9M6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_125275</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9M6"/>
    <dbReference type="STRING" id="590646.G3B9M6"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009000_0_0_1"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="855"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="985"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1039"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1081"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="277"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1158" mass="132120" checksum="BDEC5E89912E9852" modified="2011-11-16" version="1">MEVQPLCRICRGEHTDLEPLLHPCKCKGSIKYIHQHCLMEWLKHSNKSVKKCDICNTPYQFRTIYDPKMPARIPLSSILLKLMSSIGKTVGKGISILLYIVCVCIQVPIFFKFMGRLCTWGIDGRLPPENPKFIEALLYGESTFNSISFDNPADLTFHKLRHFLDHTYSSGVIYILVYVLVHLALFVEHEWVVRDEGYTKMLMKRIGKEPKSKLADMFQDALNGLRQEARDGNANAGDVVDRIELIAHAINDLNGPNLQRRRQDELIAELQENTRRFRDVDENEAHTDVPMDAEPSNAVGAPIHHNDGDNHEDGDGDENDNDDNNNNENNDTNNNDNGNDRLQAQEEFDRMMDDVLNDGEDGEDGDENNVFAMLGLNLNMSTPILLMIMCDAVISVYLFITYLIPQSLGSALVGANAVLFQVAKTVVLERPLKLMDFLLYIFYDMVYVPTIEVFSDLLRLTQHQPSMVERTITIVTGYLFIGCIAYMVMKGLSKNQSPVVGTPRRVYSALFECFATLKVFFIFSIEIFFFPVYCGWLLDFCFAPVLLDNFQVTSHEYLVLFTSVSSYFSANYVRITLYWAYGTLYMLSFALFIGMTRNKILRPGVLFFIRSPDDPNARLIHDALVKPLGLQLSRIYLSGKVYTAFIFIGIGSVTWGLRYLLNPELLSSHKNVLLPVKLYAYGDLVISAFAVLALITNKGLISRYVEIYWKRAFELSCHKLRLSHFILGKPIPQERGYVVYRSWRDSILGTKQPDYSNPVTYKEALQMFQTTDAACFFVPNGTYIRVPDNDTVSRKYIKHLFVSVTKDDRLLSVNDIVEESVEDPEDDSNDEETTTEDNYTVVYNPPHLKVRCVELIIMLWVFAVLLIISLFLTAVVLGKPVTKAISVVTGFGDFLAVRGSSGALKSIEKFINRNNWKLADITSLSIGALMELMTLAYYHNHYVAINELDHVDVWNNLFLFNNENGGNNNGNNDRLAINVRIGRNFAIPLNAITAASTFSSALLSTLWMVNAHVFVVDVPLRIYKDIDVLPFSDFYIDRWAIAGHLLISPWTIWPNIRLFFSRDLRGVETFSFKEVLHRYDLYQNLVKFCVLISCAVFITYKMHHQTYETSDLLVAPIAFGGFVVVHSFFRLKTLFNFYDQQIKNEKYVRGRALENIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA20</accession>
    <name>G3BA20_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115446</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA20"/>
    <dbReference type="STRING" id="590646.G3BA20"/>
    <dbReference type="GeneID" id="18247876"/>
    <dbReference type="KEGG" id="cten:18247876"/>
    <dbReference type="eggNOG" id="KOG4003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_0_1"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="230" mass="25804" checksum="D2BEB023D82935A2" modified="2011-11-16" version="1">MNKPALVVIDLQEDFLPSDGSLAVAGGRSIVEGIIDLLDVQKFPWAAVIATQDWHPHDHISFASQHSVEPYSQLEFTHPLGEKDETGSVKTLTQTVWPDHCVQNTFGSSIDAAFLTQFNQVDGKVPKAIVQKGYLKDREYYSCFKDTWKLHKTEMEDTLRKLEVTDVIFVGLAYDFCVMNSAVDCSQSGFTTYVIKSLCKSVFPENISQTDDTYRNGGVKILESIDDYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAA5</accession>
    <name>G3BAA5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_107494</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687563.1">
        <property type="nucleotide sequence ID" value="XM_006687500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAA5"/>
    <dbReference type="GeneID" id="18245955"/>
    <dbReference type="KEGG" id="cten:18245955"/>
    <dbReference type="eggNOG" id="ENOG502RN1R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025401_0_0_1"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="52608" checksum="ADE61B6E2ED3D0E2" modified="2011-11-16" version="1">MSVTVDQHQTDGHSKTKIVFISVLFVLSLTMFVLQTEFTSQAYTRGFKEPIILLIVTHGSWWTLWPLQVLSVAVYRVISRARRAIDPSKPGYQPLSSTTELLPTVVAPAPINPNSASPPPPTINYWLYFKKAIVKQFHNIYHTSIIIYEYHVNDDDRIHGINQLIDQHPHISSTPSITACVVSFVQTPSIQYILWKTFVLVLLLTVAGFTWYGSMALTYAADVTAIYNCSAFTAYIFAIPLLNERFSWLKANSVLIAIVGVFIVSYSDSSDGADTPYPYRFWGNLAISIGAVLYGLYEVFYKKFLCIPPHLSKLITPKRQMVFANFVMSLLGLYTAVILLVGCILVDILGIHKFNLVNYDGAGVIWGYIAGSIVSNLSFSASFLSLISLTNPVLSSVSSLLTIFLIGVVEWWLFDNVLSTSQLVGDVLVIIGFVLLTVASWNEISEGEDSDEMEVVSNYSFAISTSDDSQPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAC1</accession>
    <name>G3BAC1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_124038</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAC1"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011607_0_1_1"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="72"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="481" mass="55447" checksum="A589D9EE2C83A8B7" modified="2011-11-16" version="1">MKLLFPKIKSYHQLVAGILILWVITFFIHERFLPFYVANRCQWDQLTLSKQPEHHGFHKQHEPQVFEGITNILFIADPQLIDSHTYPGRNSLLLKLSQHTVDTYIKKNYRSFVRHLDPDYIFFLGDYLDNGRSSGDKYFNQQFRRFKNIFPHKKYGFKKDRNFFINVPGNHDIGIGDAVKLESRKRFSKKFGRLNTITTINDVDFIALDTPSLMSDNGEINGDARAFIDKQFGRTISKENPRVLLSHVPLYRDPSEKPCGPLRESPTFRLSKGYQYQSVVDAGLSSEILDLIQPDLVFSGDDHDYCDIQHSESTREVTVKSISMAMGIWRPGVQLLSFVNADEEFQYKTHMCYLPRPYYNIAHYVFMAAVSGLVLLYWNSSQSAIVGYTMLPLHNMNSKKLSDFIQDQDNENAAGSSPYIMPLPSYTNTKESPRTLQSRIRQSFDSWGLIRKRFHAIAFARQAGSVSALVVAIYVIFCKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAE2</accession>
    <name>G3BAE2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_115498</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAE2"/>
    <dbReference type="STRING" id="590646.G3BAE2"/>
    <dbReference type="GeneID" id="18247894"/>
    <dbReference type="KEGG" id="cten:18247894"/>
    <dbReference type="eggNOG" id="ENOG502QPM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012173_2_0_1"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF9">
        <property type="entry name" value="GLUCOAMYLASE, INTRACELLULAR SPORULATION-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833543" description="glucan 1,4-alpha-glucosidase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="11">
        <location>
            <begin position="64"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="519" mass="59349" checksum="E019E17A7C0BEACF" modified="2011-11-16" version="1">MKFSLWLLAVSVPLSTALPLGLKQYFFNLLVDIRSSDPFPVDPTFSDNVNKTTLDSWLADEYDVAWNNLLRNIGNSSTCLDPNIFPGVIVASPSKVKPDYYYQWTRDSSLTIRTLIHYLQDSVNKSDSDPRFQEYQWLVENYIWNNFHLQRLPTMSGDFDSGNTLGEPKYLVNNSQFNQNWGRPQNDGPGLRISSILSFVSLELPSQTGLNTTFIFNEIIKPDLLFVANNWMKESFDLWEEIKSLHFFTSSVQLKGLLDGIQFINSNSYLNVDQEVVDTLVTNYKDLKKFIESYYISTKTNYVLESPALFPHTRSGLDSAVLLGAIHSHDMNENDKLIPFDIDSNHILNHLVKIAGDMKSRYPINHHLDFSNAVGIGRYPEDVYDGYGTSEGNPWFISTATAAELLYKFAYKLVTAKEDLIITAANKDFFKLVLQLDDTQDFVVIKYKSAVFNDLIENLLKFSDNFLVVVKDHVDLKGGVSEQFNKYHGFMEGARDLTWSYSSLLNAFRWRGKVMKLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAE7</accession>
    <name>G3BAE7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_107261</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAE7"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001765">
        <property type="term" value="P:membrane raft assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="496" mass="53960" checksum="C4D953E9B928CD99" modified="2011-11-16" version="1">MGNLNVDQIVPYEIDELQQQNEKKINQINVTRAFADLPVPFSIYSALEKYLLMLIIAMIGFWGTVSPPSFFPAIPTIESYFNVSETVANLSVVSYLILQGVAPTFSSNISDSIGRRPIVILCLLIYIGATIALSQTNVFWLLVLLRCVQAAGIGPTTSITAGFSGDICTEADRGSFVGIVMGMQLTGQAFGSIIGSGLIHSYGWRGIFVFCAIGSGITLIGVIFLLPETVRSIAGNGSVRPKRVINIAPILLLKPFSTRLTNQVETLAPVTQLSLLSPFRILFRSHIIYVLFSPAIKFAVWSMTLTSLTLLEGDGYDYSVLKVGYMYLPQGVTCLIGSVITGRLLDWSYKRSKKAYDEKHKHIQESESPGFNILPSRIYISIIPSVLQFIGIVIFGWCLQFKLNIGSIIVGTCLISYSSEAALTISSTVLVDMYPTNASASVSLMNLTRCCISALGVGVLSKMTSSMGIGGCYTFWGAVGLVADMVMFYAVCFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAJ8</accession>
    <name>G3BAJ8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_94326</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAJ8"/>
    <dbReference type="GeneID" id="18250384"/>
    <dbReference type="KEGG" id="cten:18250384"/>
    <dbReference type="eggNOG" id="ENOG502S1RG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769459_0_0_1"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="193"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="360" mass="41269" checksum="632CA85CD3B6B7E7" modified="2011-11-16" version="1">MSENKYPSIHRQRASPNAKAIKIKDPKKSSIFNSDTNSSDYSSPKRKKQRFLENLKQHNKLPDTFKDATSSSGTWNYIPTSDSEDSDGLDDLLINTNGIVSENQNSSSRPKTEAKDLAESTELTPPRPQPLASTPRKTALPAKQDVLDTIFDQQVDLEEVKTRFESMNIPPVTNSKFELRHRTDKYLDSIPKFLKGTKPMSYFYDLAKESRMAAPHETMRQRDKYNIRWEIFYGGYYGLKRQMYVASVILDTYRDLITKTSSKNATVAFWGPEDFCKYVLANEIILRFIMEDYECSFSRAEEIIKETSEYGTSVTDSIDFDDDVTEETNTLELPEVVPKSKPEPTKLIKISDLFDDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAL3</accession>
    <name>G3BAL3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="17">3-dehydroquinate synthase</fullName>
                <shortName evidence="17">DHQS</shortName>
                <ecNumber evidence="17">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="17">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="17">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="17">EPSP synthase</shortName>
                <shortName evidence="17">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">Shikimate kinase</fullName>
                <shortName evidence="17">SK</shortName>
                <ecNumber evidence="17">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="17">3-dehydroquinase</shortName>
                <ecNumber evidence="17">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="17">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="17">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTEDRAFT_108220</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 18">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17 18">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17 18">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17 18">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17 18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="17"/>
    <dbReference type="EC" id="2.5.1.19" evidence="17"/>
    <dbReference type="EC" id="2.7.1.71" evidence="17"/>
    <dbReference type="EC" id="4.2.1.10" evidence="17"/>
    <dbReference type="EC" id="1.1.1.25" evidence="17"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BAL3"/>
    <dbReference type="GeneID" id="18246013"/>
    <dbReference type="KEGG" id="cten:18246013"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_1_2_1"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001256">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17 18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 17 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17 18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="20">
        <location>
            <begin position="75"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="23">
        <location>
            <begin position="189"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="19">
        <location>
            <begin position="405"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="21">
        <location>
            <begin position="1275"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="22">
        <location>
            <begin position="1525"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinate synthase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate dehydrogenase" evidence="17">
        <location>
            <begin position="1270"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="17">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="17">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="active site" description="For EPSP synthase activity" evidence="17">
        <location>
            <position position="826"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="17">
        <location>
            <position position="1195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="43"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="870"/>
            <end position="877"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGV61433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1558" mass="170480" checksum="6D8CB1CFC4C17EE4" modified="2011-11-16" version="1">MANIEKVSILGSDSIHIGYGIQDHIVGEILATQHSSTYVIITDTNMAKTSPYAKLSANFKHQLSVKKPESRLLTYTVPPGEDNKNRETKAAVEDYLLQQGCTRDTLILAVGGGVIGDMIGFVAATFMRGVRFIQIPTSLLAMVDSSIGGKTAIDTPLGKNFVGAFHQPKYVFIDVSFLETLPTRQFINGMAEVVKTAAIWNEDEFTRLENFAKTFIEVVSNTQVQLSSIKQDLIKTVLESVKVKADVVSNDEKELGLRNLLNFGHTIGHAIEAVLTPEALHGECVSVGMILEAELARYFGVLSPVAVARLSKCLASYHLPISIDDEGLLQKVGNKRKNINLDILLKKMSIDKKNDGSKIRCVLLESIGKCYQLKAHQISKQDLGFVLTDETLVHNFDANRIPTSNVVIPPGSKSISNRALVLAALGEGTVRIKNLLHSDDTKHMLAAVSTLKGAAISAEDSGETLIVKGNGGKMFTTGDQLYLGNAGTASRFLTTVASLVGINPETNEKHVILTGNARMQERPIGPLVDALRANGSLVEYLNSQGSLPLKIEAGRGLKGGRIELAATISSQYVSSILMCAPYADEPVTLVLVGGKPISQLYIDMTTAMMRDFGIEVTKSTTEEHTYHIPKGVYKNPAEYVVESDASSATYPLAFAALTGTSVTVPNIGSASLQGDARFAVDVLKPMGCKVDQSTHSTTVTGPPVGTLKPLPHVDMEPMTDAFLTASVVAAVAVDGSQSTSITGIANQRVKECNRIEAMVTQLAKFGVKANELPDGIEIHGIDYKTLKSPTAEVGGVHTYDDHRVAMSFSLLAGLCPEPVLILERSCTGKTWPGWWDILHTKFNVELDGHEPEKTLNNTNDLRDRNIIIIGMRAAGKTTLSKWISNHLGYSFLDLDDIFVERFKDIREYIKEHGWEAFRKEEAAIAAEYVGSQHKRFVISTGGGIVESAESRKLLKKYVEDGGIVLHLHRDIEETVTFLSADTSRPAYIDEIKEVWNRREDWYYECSSHHYYSPHCATSEEFENLRSVFVKFINSITGLSSVQVPTKKSYALEVTCQSTKELKKDFEEISVGVSAVKINIDYLKAVNKATVCEQICYLRTLTSLPIIFSVKTESQGGKLNDADLDLVESLYDVGFKLGVEYADIQMDLPGELLHKIVSNKRFTKLIASYRSESDWISAEWVNKYNLAVALNADVVKLVGVAKQFQDNFTLEQFRASHSSIPLIAYNEREAGKLTKITNTIFTPVSHDLLNSNELTVPESNYAYSLVGGYTSLKFWIVGEPVSHSRSPPLHNSAYEKLKLPYTFDRFESSDAAKVFSTLIENVDDFGGLAVTMPLKIDMMKYVSELSVSAKVIGAINTVIPLASHPGKYFGDNTDWVGIKNSFVRDGVPNITNMPVNGLVIGGGGTSRAALFALHDMGCKKIYMVNRTVSKIVDIKNTFPSEYNIEILDSMDAVSKADPVSIAVSCVPADKPLDSSIAEKVSAILENGIAAKVGDFVPSLLDAAYKPAVTPMMELAKTKYHWNVIRGVEMLVNQGEKQFEIFTGIVPPYDAIHDAVLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAR7</accession>
    <name>G3BAR7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_125615</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAR7"/>
    <dbReference type="GeneID" id="18249111"/>
    <dbReference type="KEGG" id="cten:18249111"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53249" checksum="B433070A627CB114" modified="2011-11-16" version="1">MTSGSYELPRKVKDVIVIGGGAAGVGATLGLLRDEDKYSSIRVFERRPQGGGLWTHTPASGSIDVPSLDPHTSVQPDSNLHWPSAVYDNLVTNVPYEMMSYLDFKWPLNTPLYPERQKVAQYLQGVAQTIDKYIEYGVSVDDVVQLPDLRWKVTVRPTNSTTTQEYIVDAVISACGHYDIPRIPDVEGLKEWNTKFPSSVSHSKLYRNSAAFAADSKIIVVGNSASAIDIANQLAEELPDSIQVYKSVRTFHDKGVRNPQVIEVPQISKFLADTKAVELVNGQTIVGVDKIIFATGYLKSVPYLKTINNLDKPIITDGNRLNGIYNHIVPYNYPGLAFVGIVLYGGPMILTELQGAWLSRLFQRDLQLPSYDEMVAWENNWAQKSGPNSAKFHELRNPDDVLYYNSLVRDIKNSRRPDGRYPDYMSQEHINIRASFDLLKKTYVAFSKINGASTGGISTFRKDANISLVESPLALGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB51</accession>
    <name>G3BB51_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_95032</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB51"/>
    <dbReference type="STRING" id="590646.G3BB51"/>
    <dbReference type="GeneID" id="18250469"/>
    <dbReference type="KEGG" id="cten:18250469"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="317" mass="35532" checksum="DCD1A7EA65A499CD" modified="2011-11-16" version="1">MSIKLNTGAEMPLTGFGVWKVAKSSCADTVINALKAGYRTFDCAADYGNCVQVGEGFKQAFESGLVKREDVFITSKLWNSYHDPEVVEKALDRILSDMQLEYLDLFLMHFPISFKYVPFEETYPSGFGTKSEIELADVPIIDTWRVMEKIYKAGKKVKAIGVSNFNGGLLTDLIKQAEVVPAALQIEHHPYLQQSQLVRFAQHKGVAITAYSSFGGNSYLELDNPAAKSSPNLLEHATITAIADKHGKTSAQVLLRWATQRNIAVIPKSNNPNRLKENLEFNDFNLTDEDFDAIRELERNLRFNDPKDWAGPNLCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBC0</accession>
    <name>G3BBC0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase CBK1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_125739</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBC0"/>
    <dbReference type="STRING" id="590646.G3BBC0"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_2_1"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21773">
        <property type="entry name" value="MobB_CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000828">
        <property type="entry name" value="Serine/threonine-protein kinase CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="172"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="484"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV62148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="564" mass="64586" checksum="6478E0B4E18CE940" modified="2011-11-16" version="1">MITTSPTFVSSSRFDDMLRRQQESMDSHSSLMFRPPASNFIQLNNNSSSNVSDISQHSGNSVLNSSVPVGNSPYQQPAQLSPQSSFARQPAAVSKLSHDKASAIKLKLENYYQMAISHAIERNQRRLDLEHKLSSQETGSSEERKNRQLHSLGRKESQFLRLRRTKLSLEDFTTVKVIGKGAFGEVRLVQKRDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYYSFQDSQYLYLIMEFLPGGDLMTMLIRWQVFTEDITRFYMAECVLAIEAIHKLGFIHRDIKPDNILIDIRGHVKLSDFGLSTGFHKTHDSNYYKKLLEKEPTPATNGHGSTKGRNSMMIDAIHLTMSNRQQMQTWRKSRRLMAYSTVGTPDYIAPEIFIHEGYGQECDWWSLGAIMFECLIGWPPFCSETPHETYRKILNWPESLQIPEDIHLSPESEDLIRKLLTGAETRLGRYGGADEIKKHPFFRGVDWESIRRVDAPFIPKLRSITDTRFFPTDELVNVPDSPALSKAMEQQNNGKQAANIKEDLPFIGYTYSRFDYLTRKNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBC8</accession>
    <name>G3BBC8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_131568</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBC8"/>
    <dbReference type="STRING" id="590646.G3BBC8"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="181"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="516" mass="58289" checksum="5E58513D4538D2BD" modified="2011-11-16" version="1">MMRLNNGSSSSVASKDKELPPVPPKADGSLLNVKTLNRKNFKKLQLHHDLDSTIPPNLEHNSPESGPLKNKRTLLNLNLGGNSNFQNPGFVNSSASGHRNLDPDSVSSTDNIINQISTLELAHQPHKSKFIRKKQTVISSISPTKSTSSMHSPSEPGGGDTGNISPIYSTTTSFKFNSKDLVTLKNLGSGNSGTVSKTLHIPTQRIMAKKIIPIESNSLIQNQIIRELKILHECQSPYIIEFFGVFINNNNTVVICMEYCNCGSLDKILGLLRPRQFPLVVLKKLSYSMLRGLVYLYENHKIIHRDIKPSNVLMTHKGQFKLCDFGVSRELTNSLAMADTFVGTSTYMSPERIQGLEYGIKSDIWSMGLMLIELASGRSIWHEDFDDKNNTNDNNDHHSQSSTSDDFTSNPGPEGILDLLQRIVNEDPPCLLNLINPVTKQKYDPELCQFINYCLIKDDKQRKSPWELLSLQDCTFLQDVKKPEYEKEVRTWAKMIRNLHKEKQDQQDREKDKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBG5</accession>
    <name>G3BBG5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115654</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBG5"/>
    <dbReference type="STRING" id="590646.G3BBG5"/>
    <dbReference type="HOGENOM" id="CLU_1992330_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="125" mass="13908" checksum="7007DAC7ED590746" modified="2011-11-16" version="1">MDTLLEKLRSSAAKSSDTKSSEDTGSATSRDKRVDRRRKALSFYSSPSVDQLEDNSKNGSELSFNDYESVNDLKRRLTRRRKDGVGGNHSSSSVNSDTTLLRTQAMLSRLRQEELKSGELSVSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBG7</accession>
    <name>G3BBG7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_125809</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBG7"/>
    <dbReference type="HOGENOM" id="CLU_1885493_0_0_1"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="135" mass="14670" checksum="43073B40029095D0" modified="2011-11-16" version="1">MSLQTNKNGPVAKRQSSISNFFAAPGKKPQKLASNSQIANYSSLTTPEKKLGLKRSDSILSRASQNDGFEDIQSSDTSFDSPEINNFRTKVLPEKQLSQSTAGSIKAPRLMKPKAPQRPLSRSSGTSSCGFETYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBI3</accession>
    <name>G3BBI3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Growth regulation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115015</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687716.1">
        <property type="nucleotide sequence ID" value="XM_006687653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBI3"/>
    <dbReference type="STRING" id="590646.G3BBI3"/>
    <dbReference type="GeneID" id="18247674"/>
    <dbReference type="KEGG" id="cten:18247674"/>
    <dbReference type="eggNOG" id="ENOG502RXS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028899_0_0_1"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39368" checksum="F42217F2BED13FC5" modified="2011-11-16" version="1">MTDNIITQVSQDNNFDSIPQPYDETSAIDYNSKIHLNIRGISFTITRDELMNLPESILLCLFPNGVFLDSRGQVITNLTEEDIVYVGFDPQCFQYITDTFNDAHLELDRLSSISPQSTGMKYSNDALHVLNTKPAIIVLREDLDYYVVPPIPGLNEESMRFLKIEVSKHLLKSTFVFSGLGYDVHSPQSEASLGPAEKHLFEMLCSSGFDPTSLWGSRSMEPSKCLLLSLSLVRLKNHPDPTPPESPNLVPVTSNASTTSRSRSRIASLANSASRAASRSLSRKRNDHSNNNKLLLFWKKPARKCWWSHESVDIPITAPHLFPNYGEKSMTVKVHMRRVWTLELSVVGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBI9</accession>
    <name>G3BBI9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_131102</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687720.1">
        <property type="nucleotide sequence ID" value="XM_006687657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBI9"/>
    <dbReference type="STRING" id="590646.G3BBI9"/>
    <dbReference type="GeneID" id="18249498"/>
    <dbReference type="KEGG" id="cten:18249498"/>
    <dbReference type="eggNOG" id="KOG4720">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012712_1_2_1"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="507" mass="58605" checksum="A24C2B63CDF018CB" modified="2011-11-16" version="1">MSTPSVYCFVSAGSVHCIPVNAFNGFSKHLDGSPQPTIQIDHHNSVVNTKQLTPVEENDIHLKIKHKNLLYNLNNPSLSDIESDSNDTNDESEYISGVIDNYLAHALYFPDYSIELTDNISDNYAQIREFLCKIFSKTWVHSEKITVQRLTGGITNMLLQCTYTPNNEIVLMRAYGPGTNFIIDRHREFISQLVLHSIHLAPTVHARFKNGLIYGFLEGRSLEPSELKHENLYPLIAQQLGNWHSKVEISKVHQGVEKLREYTRSSKRRSFDQPRPKDLHLRKEKERRIKKRYISNVWELIEDWINIVPIIPPLIESFRENSSSEVTEDNLRETIMTEFKWLKSTLESRSNSPVVSAHCDLLSGNIIIPNEELISTPLTELPPLSENPIQFIDYEYMLPAPRAFDIANHLAEWQGFNCDRSAIPEPSRSNKTLVRWVKAYLNDDDASPELVQGLIDEIYCYYGFPGFYWGIWAAIQSELSNIDFSYADYSKLRLQEYWDWKQSFLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBS0</accession>
    <name>G3BBS0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_136158</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688392.1">
        <property type="nucleotide sequence ID" value="XM_006688329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBS0"/>
    <dbReference type="GeneID" id="18249944"/>
    <dbReference type="KEGG" id="cten:18249944"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="15"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="601" mass="66883" checksum="B75B87334F698C62" modified="2011-11-16" version="1">MVSFRQQMKGFPVYQILVICLMRFSEPLSFTSLFPYVYFMIRDFGIAADETDISKYAGYLSSSFAFTQFIFTIQWGRLSDRIGRKYVLLIGLFGTSLSMLTFGFAPNYWVALSARTVMGAVNGNIAVLRTAIGELVTERKHQAVAFSTLPLLWNLGSVVGPLIGGSSFFTRPKPNGEAAAMAAVVSASGFAEWHDQFLDRHPYALSNVVVAVFLWFGMVIGFLFFEETHPQVKKQRDVGLDLGDAVLRWCGLTPKVRPWNKPEKSSTIEVGVDSEALVGSSESIGLLEDIDSDADMDPVQAPPQQLYSAIDDESEDDISIESVAMVGPLSRRMSNAIVKRYSSKSTITPQLSRTFSRLSGIAVDSDNDYDDAPLSEALTPRVVSLILASFLLAFHSIVYGEFLPVFLASSVRVDRLQFPFRITGGFGFDSDFIGTLFSTTGMCGVVVVIVVFPWLDRTFKSIHTYRATQLVFPVLYCMLPLYIFTLHQYNPKFGPNFTKVAFYCNAVAYQAINATAFPQLVLLVHRASPPRHRAFINGAALSMNSLARFIAPMTWGILMSYLDRKELGGFTWWILAMMAGVAMIQSFFLKEYDEDLKDPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC01</accession>
    <name>G3BC01_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116817</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC01"/>
    <dbReference type="STRING" id="590646.G3BC01"/>
    <dbReference type="GeneID" id="18248457"/>
    <dbReference type="KEGG" id="cten:18248457"/>
    <dbReference type="eggNOG" id="KOG1706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_1"/>
    <dbReference type="OrthoDB" id="4089008at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="414" mass="45727" checksum="99204C6123253DAA" modified="2011-11-16" version="1">MSKGKVCLAYSGGLDTSVILAWLLEEGYEVVAFLANIGQEEDFEEAEKKALAIGATKFICVDVREQFVKDVCFPAIQANAVYENVYLLGTSLARPVIAQAQIQVAEQEGCIAVSHGCTGKGNDQVRFELSFYALKPDIKVIAPWRDPEFFNRFAGRNDLLEYASEKGIPVAQTKAKPWSTDENLAHISFEAGILEDPDTTPPKDMWKLTVDPTDAPDTPETFSVVFDKGLPVKLVVGKKVFTDPVEIFLEANALARRNGVGRIDIVENRFIGIKSRGCYETPGLTLLRTAHIDIEGLTLDREVRALRDQFVTISYAKILYNGMYFTPEGEYIRAMIAPSQKTVNGVVRASCYKGSLQILGRSSDTEKLYDATESSMDELTGFSPEDTTGFIAIQAIRIKKYGEAAREKGETLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCA0</accession>
    <name>G3BCA0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper resistance determinant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCA0"/>
    <dbReference type="GeneID" id="18248202"/>
    <dbReference type="KEGG" id="cten:18248202"/>
    <dbReference type="eggNOG" id="ENOG502SCEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133919_0_0_1"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="74" mass="7329" checksum="0610406369B2B845" modified="2011-11-16" version="1">MACSLAECVCAKKSTCSCGAKPALQCSCSKAATENVAPAAGDACSCGKRAKKACTCGAAGDCAREGETDFTNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD46</accession>
    <name>G3BD46_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ribonuclease T2-like</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_116963</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573</strain>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD46"/>
    <dbReference type="GeneID" id="18248524"/>
    <dbReference type="KEGG" id="cten:18248524"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="18">
        <location>
            <begin position="285"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV61304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="384" mass="43133" checksum="7C3855BC5A5B7C4D" modified="2011-11-16" version="1">MLINPLIGFSTLGSVFFGAPDDLGTTNSCPFVPATCTNSTPIENSCCFESPGGILLLTQFWDYYPPIGGNETFTLHGLWPNRCSADNTYDQFCDPSLEVHNPKEILSSFDPALLSDLEEYWKNFNGHDESLWEHEFNKHGTCVNTIKPNCYSSYKPHQNVYDYFRVTVELYKKLDTFQFLAAEGIVPSNDKTYTKSEIQSALDKNFGGKKVYFHCNKYNGLQEVWYYHHLQGPLTGEQFVPIDASQSSRCPETGIKFFPKGSLGHIPPPPKHPSDLPTGYLKIGNGCAISSGKFFTKGTCATFRVKKAEFGGYNLLSSKGTCFVEDNALKCNRSKNTKNQFNVKDGKVGYNNVFKWCVDGTNDQKDIVLSDGTCQEFELQFEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDF1</accession>
    <name>G3BDF1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FMNH2-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_137414</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDF1"/>
    <dbReference type="STRING" id="590646.G3BDF1"/>
    <dbReference type="GeneID" id="18250070"/>
    <dbReference type="KEGG" id="cten:18250070"/>
    <dbReference type="eggNOG" id="KOG0139">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_10_1_1"/>
    <dbReference type="OrthoDB" id="5356974at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000020">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase YdbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="254"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="418" mass="46450" checksum="119146CEECA6DBEE" modified="2011-11-16" version="1">MSSNTERAEISRNEAITEWQNQTPTSEKEWVSRAQRVAQILNIDAAERDEKGESPFKEIGLLKAAGFVNLLGPQKYGGGGQTWELAYKIVIEVAKADSSIGHLLGNHYSWFWSAVYFGTDAQREKWIKILTENDSYIGGAVNPRNSDLLAKPDGDDIVFNGKKYFCTGSVVSDHLILEGVLPSGEHVFAYVPGDHPGIKYLHNWNSIGQRLTESGGVVVDNVRVKWEDALGFSPSGDKLVDDVYSTYILPAVQLVFAGVHIGVAIGALETAAGYTRDYTRAWPYGGDNKEKAVDEWYIREGYGALAAKVWGAEALYREVAKLSSDVLHSDRKSLTERRRGEIAVKVAATKILGAETALEVGSKIFELTGARSGLRNFAFDRFWRNVRLHSLHDPLPYKKREVGSFFLLDEIPTPSWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDV5</accession>
    <name>G3BDV5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_95839</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDV5"/>
    <dbReference type="eggNOG" id="ENOG502S5V9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368802_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="755" mass="87440" checksum="7B0359D3ADAB0C29" modified="2011-11-16" version="1">MSQPARKRNRKVVVCLSCRKRKNKCDRRRPCTSCIKLGLHDSCSYVVDEFSISSNPEVFYGTIYLKQDPVPEPTALASVLVSSNLYPFQILDPKDPTATIISQYWAYKFGIEKFNQTLISSSFIGLNSLSRKHLEMNYNMNNSLDYCEVESGLISIYETKQKVHPQALQRGVTYHPDPLLRTYSFLERLKKVVPSQAQLMKYQSIFFAKTHILIPIFDEVSLEEATKRIFNLENATKNKIVEVTITSKTDYAVIASSLLMLRYTYLDSIICKHFDPDLDEHVCVEIMEVVEECFNLHGIIKRPSLPLLQALLLYHFCRDISPEIQDSFLVDQTLKNQILELCYTLGLNRDPEVYTMEHMDAKTVHLRRKIWFFTYYSIACDSMMYWRVSKPLIYDYDTKFPRFKADCMNVRNATNEKKGIDGMGYAKIITKVVNESLKPAQRVNSEFRGVTLYEYANSLKIFFWNYSGSYESIHDSDVSGSFTFLKVRSFILGRMLTALLQFSAYLKLEEEGSLEESKESLIGCVFTTFDELGKVDGDSFKPKSALYLEMFTSVYNPWIIKLLYMIICISLSLLIRIKYSMLTMEEHGKDNDILYLRMKQWFRMIKVVMLKRVKSLISFSKEYAMANMLVKITLKNLNSTLGVGKTLPVDSEKAKRCRLKLCLADVERMMSSFQPPEVMHEADYLANLDVFTVSDILKSDCDCDSDSKLAVFIKYDKLWIARTLIDMYYDEEYVKHEGEAPNDLFNFDLTPSQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE40</accession>
    <name>G3BE40_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aries arylalkylamine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_110459</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE40"/>
    <dbReference type="STRING" id="590646.G3BE40"/>
    <dbReference type="eggNOG" id="KOG4144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061829_0_2_1"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="225" mass="25249" checksum="FDEC638AF706C724" modified="2011-11-16" version="1">MSDFPPNLSIRPLTIEDVDQCIALEAKGFSKNERATLQKLKYRLTVCPELCSGLFIRDYKYKYNAINLPSVAESLEKKHEVVKRSGDDDDLEDLPMSSSVIKETLVGHIIGTKMSSARVTNEAMDLPTDNDDTTGHIEGSRYIGIHSLVIDPEWQGKNLGTLIMHDYIQKLSNQDLGDKVSLLCKDKLVPFYEKIGFNNLGQSECKFGGVSWIDMSMDLIPEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE67</accession>
    <name>G3BE67_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_127730</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE67"/>
    <dbReference type="STRING" id="590646.G3BE67"/>
    <dbReference type="GeneID" id="18249257"/>
    <dbReference type="KEGG" id="cten:18249257"/>
    <dbReference type="eggNOG" id="ENOG502QVVM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_8_2_1"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000100">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="502" mass="57235" checksum="F70322E689FE9D15" modified="2011-11-16" version="1">MFDNLKVKSKGSKIEPADPPVSPGAKPTKKQIYQARQNYGVNLGACFVLEKWIYHGLFIDDTAVELEATKKSVKKLGKDDTRKKFEDHWNSFMSDSDWDWLESHQVTSVRIPLGYWEVDGGKYTKNTKFEKYAKDVYKNAWSIFKEKFIEKAGTKGIAVLVDIHGLPGGANGDSHSGEKEGGDAEFWSSQGLQLQVCDMLKFIASDLKKYDNIAGIQVVNESVFSNDTKRQRYYYGAAINSIREADKAIPVVISDGWWPDQWVKWVQEKQSSGNIGVVLDHHCYRCASDDDKKKSPSQIIDGLNNDLLTNLSDNSKGVDIMIGEYSCVLDGQSWDKDNSSSKRDQFVKNFAKRQIELFNERANAGSYFWTFKFEAGSGGEWDFKTMSDNGVIQSPIGFKGKSVPDDRKRDEILDHEFNNHKSYWDNSNKNEKYEHDRFKDGFLTAWSDSKAFAEFNGSVIGRREAWKDARLDEHIKQKGKGKHVWEWEHGFDSGLKSFKNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE68</accession>
    <name>G3BE68_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_127731</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE68"/>
    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_1_0_1"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="316"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="560"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1131" mass="127480" checksum="2C17071EA3EEC488" modified="2011-11-16" version="1">METRDQEIPFSKWPDPLKRLGRIFSQINANLTFILSHSRSTIPTYEYFQKLVPDLTIFDLASIKYFLPPGDVFFDYVDKEDLLANEKVGYTKEQGYNMKQPDTIDKLYEDIKNANENGSSQILLFTFDDMKVDNIGALSNSRRAPWKRTNTESNSFFNHRDLITQKLTQPQLSGIINTRNAKFQAGVSHFVQEVGTNTEELLVLDKLNADVVSFVPSEPDLEDPVQKMTKRQRLENTSVSESLDSQGMVDILKNSSIYKDQIEFEATFTEARPATFKPFDLEMYDIHPALAYGVKKYKGIDMETMLYSHQTEALEHILDYTKTHVITSTSTSSGKSLIYQIPILNSILWDMENGNTNHRASTAIFIFPTKALAQDQKKHLEDLIKHIPMPKNGSIRVDTYDGDTDTKTKGTIRRFANIIFTNPDTIHASILPNHEGMSYSDSSGGWQYFLHALKFIVVDEIHVYKGTFGINVSFVMARLLRVLSHSSSSHQVKFISSSATVLNPESHFRVVCAISPEDNVVHISNDGSACCEKKFLIWNPPPLMNKRVNNITESARVLLSLLGGSKFIKVIVFCPIRQVCELLMKQIRSLLITSEYADLGIKEGDIMAYRGGYSKTDRRNIEQKMFNGEVRALVATNALELGVDLSDLDVVITCSFPVSKSNMHQQFGRAGRGRNAKGSLAIFVAGAIPVDSYYVKHPEELLDKSTYEDLCVESLIGVGMHKLIMENHLQCAAFELPIDIDQDAKWFCNYESTPKKVQIFRTACAEKLNQDKLHRYRTSPDYLPWPASKVAIRAVESPAYAVVDITNGRNIVIEEVEESRTSFTLYEGGIFLHQGLPYLVKDFNSDKKYAKVQRVTVDWVTSQRDFTDVDPHIIEYIRCLKSPMREVSDIPAYFGTIEITTIVFGFFKVNKKNEIIEAVEVKNPPVRYKSKGFWLDIPKPVLDAIVEKSLSPAGGIHAAQHCLMNILPLYISGSATELLTECKAPEKEFARRQTKRKRPARLIFYDSKGGPSGSGVSAKAFEYIDEILLAAYDRVKDCDCEWGCPKCVTASFCKEGMTVMSKPAAYIILGSLVGRELSELVQEVPDGPELNMPEISVETVQPASSVVKMAKDVEIVEIKRATKPLKPIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEM7</accession>
    <name>G3BEM7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_109949</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEM7"/>
    <dbReference type="GeneID" id="18246158"/>
    <dbReference type="KEGG" id="cten:18246158"/>
    <dbReference type="eggNOG" id="ENOG502SAH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098734_0_0_1"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV59930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="246" mass="27918" checksum="D211499AD7EBCE63" modified="2011-11-16" version="1">MLLSSVRHYASHKGSYKSPDSSIETDEIISENNPWSPTLLTDRVKVRKPGYVRSVELPENLRLSYQPLYEAPGSKYVALLKRLTISVGVLGCYGAKLFYDSPHFDDYYAVSTLAACSVPAMVVQYKTREYVTRIFRLYDKNKPQTLENLVNDEQLIVEKLNFTGGKTFNQLVRVSGNDSLKLVSTPKVPLLASYAVWQDKEPESGTVRKHYIVDDIGGMKMDRLWGIVEKNSGEDNGRYIDYNKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF01</accession>
    <name>G3BF01_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_116003</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF01"/>
    <dbReference type="STRING" id="590646.G3BF01"/>
    <dbReference type="GeneID" id="18248118"/>
    <dbReference type="KEGG" id="cten:18248118"/>
    <dbReference type="eggNOG" id="KOG2460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018649_2_1_1"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="575" mass="65618" checksum="37FD895A59854CA5" modified="2011-11-16" version="1">MDSPLSITVGARMSAFLNSAEDFHKYRKRLNKTILRLRHELNLVTRDTKNYKDKERISKISSEDYSNDERFGLILLLTAERDLVYSLEIKSMMEISSEGSSSYKNLMVSRLKKSVSSTKQLLQVVENETNELKIIEVYVYAALNEGSLAVNKRKWQSALNAFSIARCALEYLYSQQTDQEQEQFNKTVINDLIETLVDPSLALSVSQIEELDMSDLKSTARRHCHDKTLPYLQTVVELIKKKDPEFVSQISSSIKLIDSITWRSHEASLYNDEIAFKLMELTKPEVNEYDNLEAFDQLISGWSGVLELHQADLNKNEDEDDSEKIQNRAVLLTYINYSLLFTRIRRDQILVGQLLGEFEEVSKTRKLVINKDITRLYSSSIRTIDEIKELPGVYNDDDLMESLDTMSQFYSYSILVRLSNSFLLNNKYLESLKVLNTIKEKIGINGLSYKVETFPYSVSSNDNLEQFKADINKTFLKTQILAQFSFELNKNPHEAVIENMHQFPGSSKLVNVGTSPVIKPILSKPVLFDVAFNYINYPGGSSKSSSVEPQSAPPQTAGEEESKKKLGLFGFLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF26</accession>
    <name>G3BF26_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase-assembly factor COX23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_111501</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF26"/>
    <dbReference type="STRING" id="590646.G3BF26"/>
    <dbReference type="GeneID" id="18246287"/>
    <dbReference type="KEGG" id="cten:18246287"/>
    <dbReference type="eggNOG" id="KOG4618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153383_0_0_1"/>
    <dbReference type="OrthoDB" id="4096032at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="133" mass="15716" checksum="D3A2D774C5E53B5B" modified="2011-11-16" version="1">MPEPTKETAKEAPNQSTKPKTINSSEQKPSYDYVETRKDKVDFTKGGVDNYKFYPDNPNSHHHKYNWVNKEPSKFYDPCEQSRQASINCVLRNQDDRSVCQAFFDAYTECRRDFFKKKKEDRQKGKGGWGFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF37</accession>
    <name>G3BF37_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_110524</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF37"/>
    <dbReference type="STRING" id="590646.G3BF37"/>
    <dbReference type="eggNOG" id="ENOG502QUUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_3_1"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="10">
        <location>
            <begin position="750"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="867" mass="98455" checksum="619060C7E3560F8C" modified="2011-11-16" version="1" fragment="single">DWDRGGNTKSNSLTPLYSLSKKYIEANPGAVCLIQVGSFYELYFEQAETYGSKLGLKVATRKTSNHNVPMAGFPVIQLQKYVKILVQDLQVNVAIIDQFPGEETIGDKMIHRKVSRIVTPGTLVDETFMNYNENNYLLAISFPTGCNKQPHDPDMPVGISWIDLSVGDFYVQQTSLSELISDISRVNPSEIIISKEFINEDLPAWYSGLHDLRKYFIRYHKTAYNDLKLSFKSNLNGIRKLIETFSVREEAAMNMVLSYINVNLPERNPSLDLPMKYWNEKYLQMDSRTRDALELIERNSGTSGKSLTVGSLLNTIKKTVTPSGTRLLTEWIKSPILDIDEIKHRQEFVKFFLNNQYQATIIEKLLNSIDDFVRSAQRLTLGTGDTIGNLKSISSGLQTSDELKQFLTSNRPSEFEDLIDNFLMEFKVPSEIATEINDTFEVVSLPGVEGVLEEDTITELESNTSRSQDMVQFMVKKDHNDELKELHESLAIMKDKESILFASIRDKFLEIDDKLTVQIKQQHAKFYDVIYVNGKSKSIDLINKEFQEHIRDKRKNMVLFKSNDWKFLQFEISQQLEKIQELENQIINNLKEKTVQKVVEIRRLSKLLDFLDVTLSFSKLSHEFNLCCPQFIQGNQLVIEEGRHIVVESSLKNIGSNFTSNNTKLNRNSKQWIITGPNMGGKSTFLRQNAIIVVLAQIGCFVPASKCQMDTVDKLFTRIGASDDLFNDLSTFMVEMVEVSNILKNATKKSLAIVDEVGRGTSGREGLAIAYATLVSLIKVNKCRTLFATHFGNEIKQLLDSDSTTKQSIGFFKTGVVTEKQGDQIHLTINHKLEEGISERSYAIEVAQLAGFPKYSLKIANKAYKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF60</accession>
    <name>G3BF60_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_128081</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF60"/>
    <dbReference type="STRING" id="590646.G3BF60"/>
    <dbReference type="GeneID" id="18249280"/>
    <dbReference type="KEGG" id="cten:18249280"/>
    <dbReference type="eggNOG" id="KOG0458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_4_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="147"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="575" mass="64987" checksum="F5C817B53953F2EB" modified="2011-11-16" version="1">MDDDYSDDGSVEFSEDLLNDQEYDQLLDTLPVLKQKLAKFDKGSQINELVLKESLYDHYFEVEEALEDLKVSHKLKRTYKFSDYLSSNFNTESPDEKVLNAQKKAFDDFNKLNIKTSKKEDKISKILDQSLKVDIKSELATNKQFKKPHKSFVVIGHVDAGKSTLMGRILLDLNIVDLKTVNKLIKESESIGKGSFALAWVMDQTVEERSRGVTIDIVATNFETETTRFTAIDAPGHKDFVPHLINGLCQADLALLIVDSITGEFESGFQLEGQTKEHTLLAKNLGIKNLCCVINKLDKEDWSQHRYEFIKDQLTDYLINEIGFEQSDLSFIPVSGLSGNNVIKRQDIPEFKWYEGQTLSAYLETIDVPKPSVDEIIKEPFNLVINDIIDNSNSEFTVVGKILSGVIQINDSVSFLPINEIFKVNKINMGGNFVKFSVSGEIVELSFSKKQFKEKTFEDVIIGDIVSNSTDIKPVKSFTCRLSLFNLQKPLLVGTPFVLFRNNFNIPARLTKIIEIDNSKKRKKHLISKQSALVEVEVEGERLLPLTIFETNPHLGKVVIRREGITIGAGTVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFD4</accession>
    <name>G3BFD4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116050</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690204.1">
        <property type="nucleotide sequence ID" value="XM_006690141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFD4"/>
    <dbReference type="GeneID" id="18248145"/>
    <dbReference type="KEGG" id="cten:18248145"/>
    <dbReference type="eggNOG" id="ENOG502T5ZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058653_0_0_1"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22702" checksum="6DD4097EE4AE0B37" modified="2011-11-16" version="1">MNCFDDSYISHNLHSFDFTHNIDYLDDDTHIPDEVLIKCYKQSKYDISIIIPSTAPLRLQNIAWRRLYKSLRKLPEVSPRVINWHKQLDINWCFGPSYSHEDLITPPEKVEVKAAPIGIPDAYPLLYTVSNSSSDTLTDSDSLLSNSPTSTCSSHSNLSVYHGMKKKRVKFNFIVNSREIINGISIDYDFLDDSILND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFF4</accession>
    <name>G3BFF4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein KRE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116729</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFF4"/>
    <dbReference type="STRING" id="590646.G3BFF4"/>
    <dbReference type="eggNOG" id="ENOG502SFZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2003620_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031452">
        <property type="entry name" value="Kre1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17056">
        <property type="entry name" value="KRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442834" description="Protein KRE1" evidence="2">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13231" checksum="69A8A25CB5A2D8AF" modified="2011-11-16" version="1">MRLFISILFALQLIFFVHADATTTTNTLVWATGTISGKLTTYQSIYRQKFTSMYEEVSSPVSGSMGLGSLSGQVGQIRTYDQTTITATNGASPGRSHPSILAVSGSTQGLIFLPLLAGAFLLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFK1</accession>
    <name>G3BFK1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese and iron superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116055</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFK1"/>
    <dbReference type="STRING" id="590646.G3BFK1"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057349_0_0_1"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="265"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="38593" checksum="8C108491C529ABAD" modified="2011-11-16" version="1">MLKSHICNRVLRAPTAFRAVRAVSSYTLPNIHLLEELNVNKQDFKGLFSHSTYNQLWFQRGEKLIEELNELLIENQVNPPNNLNELISLTINKPQLQKIYSNSSLLFNLQFFLEGLKEANETYEFQQLNEGEIFRNPDITEVSSNIPQNEAFKDWLSASFGSITEFKNLLLNSAKAIKGDGTTWLVAQPNVSESSLKSNFTGLFNESNEPKYTKLSVMNTYNAGVVDDSIRSGQLFKLQQQKKAKLVMEQEKEGTQVKQTPETENYLGTVEEAEFTHSFSDKKIIPLLAVDASLRNYLLDYGVFGKQQYLENVWNCVNWSVVEQRLPPRFIANFTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFN9</accession>
    <name>G3BFN9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">I-AAA protease complex subunit Mgr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_126892</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFN9"/>
    <dbReference type="GeneID" id="18249202"/>
    <dbReference type="KEGG" id="cten:18249202"/>
    <dbReference type="eggNOG" id="ENOG502QR67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871878_0_0_1"/>
    <dbReference type="OrthoDB" id="4087899at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013911">
        <property type="entry name" value="i-AAA_Mgr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08602">
        <property type="entry name" value="Mgr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="336" mass="38162" checksum="3C414E3D348AB7CD" modified="2011-11-16" version="1">MGVYIPPNNNNGDQSGDQNGGNPRKPTPVELFLREKLNFGTNPSFGLHFWGPLVPPPDNRTALKALTAAQFFLGLGLISRSFALRSSRLLRNGRVPSWSLSFKKYTYGLVGLNLIFNSGLETTRLISPFDPWQQERQYYTDLALRNGQPVHWWFGPKNYVPMTIDAFVEEQFVTQAVHRLKSQNAQDLGQFSDTVQAAVVPPHPAAASRPILQISSISRLLDHEKFTQIYNNIRQENEAIANNLLTNQLKDESEINKGNRLDLMMEGKYQFVVDENYPKPPIVLGNRRLETDDDLDAVWDYYDPWAELQVETDISIRLIPPSRFGEEEDVDEVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW33</accession>
    <name>G3AW33_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dityrosine transporter A Q resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_128854</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW33"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_7_1"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005275">
        <property type="term" value="F:amine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001765">
        <property type="term" value="P:membrane raft assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF21">
        <property type="entry name" value="DITYROSINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="464" mass="50724" checksum="C21BD1DB9C4A39E3" modified="2011-11-16" version="1">MAVKDLPSEKNSSVKEETFTNTRRNIILAVVTCAGFLGPLAGNIYIPILPLMSEAFNVSTSIINGTVSVFMAVFAFSPLVWAALADVGGRKSLYMFSLLIFLVANILLTFLPAHIGALYTLRVIQAIGSSSVLSVGAGTVADITPPTIRGKTIATFMLGPQLGPIIGPILSLATTNGQWRWSFGILSIFTIVVYIAILFLLPETLRYLVGRGECYEGKSYFVKPKLYEKKRTAEDAKYPKPPKLSPLLYFKLARYLPVLISSVAGGLLFASFYGISVTFSRVLTNDYHFSNLHVCLSYLCPGIALIIGSMISGRLSDKLRRNRIAKGISFIPEDRFPIQLIGFLVAIAGFTGYGWTCEKHSHVVSIFVTVFISCFGTTWVLVTNLTYLTESAEGIPASNVAFGNFMRNAGAAICSGIITKLVERMGYGWCFTGLAFVNLGGATFMILLFSKGKHWREKYGYLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW74</accession>
    <name>G3AW74_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like protein ARP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin-like protein arp6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_128878</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW74"/>
    <dbReference type="STRING" id="590646.G3AW74"/>
    <dbReference type="GeneID" id="18249346"/>
    <dbReference type="KEGG" id="cten:18249346"/>
    <dbReference type="eggNOG" id="KOG0680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_1_1_1"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="399" mass="44483" checksum="26F3B4EEE7F6AF51" modified="2011-11-16" version="1">MTYLVVDNGSYSVKAGFAESNEPTIQHNAISKAKDGSLYIGSDYISTNNHSGLIFKRPHEQGHLTSWETEKPVWDYTFDLLSKKDINPTDLGLVLTETPFQLPQLSMNTDQIVFEEYGFGSYYRCIAPSLVPWTYAGDPDFSLVVDCGFSATWIVPIIYQSVYWKGVRKLPIGGRALNGLLREIISFRHYDISDEPVLINTIKESTCFMAQDFGAALKKKLAHECEFVLPDFKTTTTGYVRQSGQRGAGDLQSLVLTDERFVVPESLYRPEIIFDNAPSTSAILQTAPIKNLTDLVVEAIMTSPVVARPLLSQNITVVGGTSLVPGFSTRLEDELAKELPSDWKVQVVSSGDHKPDVASWYGGAELCQSEIIDKVTISKQEYYEHGSNWCQTQFGFRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWH0</accession>
    <name>G3AWH0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_91705</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWH0"/>
    <dbReference type="STRING" id="590646.G3AWH0"/>
    <dbReference type="GeneID" id="18250103"/>
    <dbReference type="KEGG" id="cten:18250103"/>
    <dbReference type="eggNOG" id="KOG0779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_346811_0_0_1"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="253"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="775"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="814" mass="93245" checksum="539521163B0AF7AD" modified="2011-11-16" version="1">MGSSPPESPIESPHHGPTPIPEITPSESKMKIVRDIYGSILSIDDCQAQENPATHLVICSYTFNKKTRPTDGLTSHLNVSPNRQFMYITKSAAIKDHTVINMFKHVEQVLICRKEGILVVLNDNGGYVFFRHDRYSEEFYDFIVASYSSVEDASIEDVHNKMTGIDESRSSEKQSEQEPHTYRFSKDLEKKASPSFPRIPPEVMYSSEDAVPILARKTRSRMVSPETISLVPLESPAPFVPPLQYKFPDGKPFIVTQSDFKTLYNNDWVNDTIIDFFIKFEIQQAVHNGNMKQEDVYAFNSFFFLKLMSNPENFQDRELIGYYQNVTRWVSKIDLFSYQNLIIPINESSHWYGCLIVGLPDYLERAKTLKELNESQAHDYVGNSTDVVEPEVHSIFESRFKNKVNIFVFDSLGQKHVRIHHPFKNFLMEYCKDRYGIEMERSDIVFRSTKVPKQNNFNDCGIHVIYNIRKYLNARAECLSIWNKGSSQYKAFFKSSERAGMRKELIQLLLKLHNEDNPDKNKEEAGPENSENGVGSETDTGTNVEAGSKVSKESSSTADDRCINVDSGNEKGCGSEDDEIEVVQVKNLDNVRQHRIKARGRNGTNRLFVTIANGVNLKADTYGVDQKKSSNECIQELVDGIGERSNWETTERETDDINENLSNQALKESRISNDISAVAVQILNELFPDPRETFTSNQILEITKFIKDINHLTFKRDSQKVEHLKKAFRETYDRLDPSRPMNAEFKITFDTALSKKTSETNHDDSDDTDALHETLSINSGSHTEGVLRTDKAYSPSRRWEYTETQPRDKRQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWI7</accession>
    <name>G3AWI7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_128943</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWI7"/>
    <dbReference type="STRING" id="590646.G3AWI7"/>
    <dbReference type="GeneID" id="18249353"/>
    <dbReference type="KEGG" id="cten:18249353"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="199" mass="22127" checksum="0CC42D1B6F75CAD4" modified="2011-11-16" version="1">MVPPSAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGRKVELALWDTAGQEDYDRLRPLSYPDSNVILICFSIDSPDSLDNVLEKWISEVLHFCQGVPIILVGCKSDLRNDSQTIELLRQQQQQPISSSEGQSVAQKIGASNYLECSARTGEGVREVFEAATRASLKTKEKKEKTKRKCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWK3</accession>
    <name>G3AWK3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_101051</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWK3"/>
    <dbReference type="STRING" id="590646.G3AWK3"/>
    <dbReference type="GeneID" id="18245433"/>
    <dbReference type="KEGG" id="cten:18245433"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049076_0_0_1"/>
    <dbReference type="OrthoDB" id="2264563at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043633">
        <property type="term" value="P:polyadenylation-dependent RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016713">
        <property type="entry name" value="Air1/2_Saccharomycetales"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018162">
        <property type="entry name" value="PolyA_pol_Air1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="316" mass="35567" checksum="8127CB3AFB549023" modified="2011-11-16" version="1">METTTNTRPPTPKQGFADQIQSLSFDQVNDNADELIELRGSGRYFGVVDPQTGKTINNKQSLGPICANCHKRGHIRAKCKTVVCHKCGVVGDHYETQCPSTMICARCGLRGHKAIDCSNKARKKQYCRTCDLFNHDDDNCPNIWRSYLLNKQPQQHSLKDVQLPVIYCYNCGDSTHFGDECKEARTSRVPNLSGSAFSGSNLPQQLRKTYFDRLFDTKLPQRPQVRRPDNGYKNSNNRAQFKPYNNNPIVSNNSYNLNPKRRFDNGPQDNRNGGPIRNQARRGGAGGRSGGNDPSRPAPTRSGFIDRKKSGFNNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWN2</accession>
    <name>G3AWN2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_96597</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWN2"/>
    <dbReference type="GeneID" id="18250616"/>
    <dbReference type="KEGG" id="cten:18250616"/>
    <dbReference type="eggNOG" id="ENOG502S73R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128832_0_0_1"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="156" mass="17600" checksum="D2C8794DA4096C25" modified="2011-11-16" version="1">MGLELKDGESLHANIKGTPEGYTGTTKLKSTKTSYVLLLLTIIICLLIFHFRNKIAEFHDRLRTKRRMRYANLSQGFQDDLESGLNSDAFNILSGNSNDHRQGLEENAKAAIYQLMQQKSLTFDEARLEYTKSQFGEHNIDSNGVPLDPKTVTFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWS3</accession>
    <name>G3AWS3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Auxin efflux carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_117682</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWS3"/>
    <dbReference type="eggNOG" id="ENOG502QU6H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021924_0_1_1"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="56533" checksum="B83E08E962EB9AFC" modified="2011-11-16" version="1">MAVALGSIIYSAVKPIFKIYIITGIGFILAKRNVLTVSTCRDISDAIVTAILPCLIFTNIVKNLASSDIKSVGIIFFTATVLFGVGILFAYITYIVTRSPKRWLGGLLSVGLFPNISDLPIAYVQTLTNGGMVFSESEGDKGVAYVCIFLAAQAFYQFTLGLYALIQWDFRDEDDDEKVIGSGSDTASARHTHDTISSNASTPNADSYDDALSISSSLPSNQMVEVPLPTNLGEETYRTGSQRLSHRIGTASLLPIRSRDLRSMKSQDIGDVINEYSEYDRLNDNSNLSGVQRMITLGSDTIGPAIMVGGESLSKPLTNASKIEVVTSKVRQRLYSILKNTLAPVSISLILALAVAMAPPLKALFVSSAFSIPDAPDGLPPLSFLLDTASYMGQASVPLGLLLLGATISRLDLKGMPKGFYKTVLGIVLFRLVLLPMVGVGLVAGLNRAGWYDGNKLIRFISVLEFGLPNATALVYFTAFYTDPNSEDHIQMDCLAAALISQYAVLFITLPFLVSFTIKVTLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWV2</accession>
    <name>G3AWV2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112338</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683883.1">
        <property type="nucleotide sequence ID" value="XM_006683820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWV2"/>
    <dbReference type="GeneID" id="18246477"/>
    <dbReference type="KEGG" id="cten:18246477"/>
    <dbReference type="HOGENOM" id="CLU_2426791_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="91" mass="9896" checksum="20620C329ACC184B" modified="2011-11-16" version="1">MSTSSLELNDANATVGLTTPQLHDGEVAGDVSDTSGFKKEAVNTVFDVALSIDTEAKQLLETLVKNDDEITDRLESISVKIRKIRSQMDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWW8</accession>
    <name>G3AWW8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112347</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWW8"/>
    <dbReference type="STRING" id="590646.G3AWW8"/>
    <dbReference type="GeneID" id="18246483"/>
    <dbReference type="KEGG" id="cten:18246483"/>
    <dbReference type="eggNOG" id="KOG4510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="48"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="220"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="427" mass="46805" checksum="D962A0BCA95B6FAE" modified="2011-11-16" version="1">MSQPSMAVPSLNPAFEEIPFPSLSRPRSGFKTLSRLYTDLVNNDEVFGFTLLILGQMFNTVMLTTCKLLVTDDNPIHPIQILFVRMAITYICCLLYMLITRSVPYAPFGEPSVRKWLLLRGVVGFFGVFGSYFSLLYLSMSDSVAITFLVPLITGFLAWILLRERYSLVEAMCGLVSLCGVMLIAKPHFLFGSEADKEAGSADDSVESSSTEKRLLATGVALLGALAAASVFIILRKIGNSAHPLISVSFFSMVTVVISSISIIVIPSISFAIPQDSYQWSLFFTIGIAGFLYQFALTAGVQRVKASKASLVVYLQMVFAIALDVIIWHHFPGFLSILGILVIVGCTLVVMKYKSKPAAGDLERGTHQPLSQDDDGYKPEDIQLQDFVIDDEDDENENVNFSPSPESATPDVELNSVKDSGAIKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX79</accession>
    <name>G3AX79_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_100544</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX79"/>
    <dbReference type="STRING" id="590646.G3AX79"/>
    <dbReference type="GeneID" id="18245390"/>
    <dbReference type="KEGG" id="cten:18245390"/>
    <dbReference type="eggNOG" id="KOG3336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067902_1_1_1"/>
    <dbReference type="OrthoDB" id="2507562at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="217" mass="24772" checksum="0205860356082320" modified="2011-11-16" version="1">MKLFESSHDFHYPWDQVTAANWQKYPNELSSHVVSVDILNRYIDPATNVLRTERLIGCKQPIPKWLSMLVGGQEYSYVREISEIDLSTKTLVMKSTNLTMNHLLQVNETVTYRPDHELPNSRTHFTQKAEITAFASFSRVCDKIEEWSVERFGQNANTGKQAFESVLKTLTAKWEESGVFVVDIGTSLLNDLNHVTDKTSTVLAEVSKLGNVFKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXP5</accession>
    <name>G3AXP5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112535</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXP5"/>
    <dbReference type="STRING" id="590646.G3AXP5"/>
    <dbReference type="GeneID" id="18246565"/>
    <dbReference type="KEGG" id="cten:18246565"/>
    <dbReference type="eggNOG" id="KOG4411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037269_6_3_1"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40749" checksum="FEB23F08C52DBDEA" modified="2011-11-16" version="1">MGGIRYLGMTAGGGYAATLEIAREDVNKILESQDRSSYLLAQYMPEPTRDAFLAIRAFNLEINKIAPKQSSGPSPLGVSAVDLKFKFWSDLLTRIFTNPDSDTNIGEPIAFLLRDALRNNLNLELSCLHQFLQSRRHFLNSSGFNSTDDICAYGEGTYSQLNYLTQGLLLSPGISPSAISLLEHSRRLQGLVSDVAAHIGQATAVASMVLGSKYYASKNSVTVPVDVMTRHDVSQEQFLRLAQGHDQDMAATRQSLQNCFYDVAVVANDHILTARQKLQEIREETAKVVKSNPNDKLLQKNHRKWRHGIPDVIFLPFMVSIPTTLYLRRLEKNDFDIFAPAMDAKEWRLAWTSFRGYYQRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXR4</accession>
    <name>G3AXR4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_112546</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXR4"/>
    <dbReference type="STRING" id="590646.G3AXR4"/>
    <dbReference type="eggNOG" id="KOG2283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="89"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="355" mass="40656" checksum="10A2CA1E20839693" modified="2011-11-16" version="1">MLMKSLIRSIVSLPKIAYQDEQDIKYDLAYVQHNVVVSSGPVSSSFKKWYRYPIEDLVKVLTYNHKKNWHVWNLRGEGKGYNEADVLGQMSYFPFPDHQPPSFYLLMQVVESIDRFLSQSPENVAIVHCKAGKGRSGTVACAVIMYESYKHGISMSAHEVNELYTLRRMRPGSGKGVSIKSQFRYLQYWQNYLDASEDKQKAIMLVNQVNSPIMVQFTEVKLTNTVRYLTNNSENAAEINVVLQGYNPRKDVECGVELVQIWEYNNKDDTVQIEGRDVILRPGHHINVAHVCDYRVFVNGVLFAWFNVSLETEIDTLKGDFAVKFKEFDGFKGTTHRGAPLFETLTISWKVAVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXW2</accession>
    <name>G3AXW2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_112571</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXW2"/>
    <dbReference type="STRING" id="590646.G3AXW2"/>
    <dbReference type="GeneID" id="18246588"/>
    <dbReference type="KEGG" id="cten:18246588"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="20"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="373" mass="40144" checksum="34ED680C4B9FD106" modified="2011-11-16" version="1">MFSKTIRAFSTSSTSLKNIKIGLIPGDGIGREVIPAGRAVLENLPSKLGLKFDFVDLDAGFELFQKTGTALPDETVKVLKEECDGALFGAVSSPSVKVEGYSSPIVALRKKLGLYANVRPVKSVEGIGRPVDMVIVRENTEDLYIKEERTYKAADGTRVAEAIKRITETATTRIAKMAYDIALKRQAIREASSATGLHTSPSVTVTHKSNVLSQSDGLFREICRSVYDANLGLYDSIAYREQIVDSMVYRMFREPEIFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGENFAIGEPCHGSAPDIEGKGISNPIATIRSTALMLEFMGHTDAAATIYEAVDANLAEDSIKTPDLGGNSTTQQVVDDIIRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXW3</accession>
    <name>G3AXW3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_133119</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXW3"/>
    <dbReference type="HOGENOM" id="CLU_642487_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="427" mass="49819" checksum="E3FEDFA60F90F4A1" modified="2011-11-16" version="1">MMTCPFNFNKLFVSAPPKRCSSEINMSFDDLPVEVIKIILDYLDQWSLVQMLTCNSYIFQMTKPKLYQDILVYDIAFHRRLNLSKGFTSLPKELQFMNPENYTILSTRNFLDLISRYTFEPNLVNTIYFYHYVPSKQLFSQCAKFGCKIKIKDRDVDSDNSTTRCHCEMKIGNTNVDIEGSLDYVLPELGMSFPEDLKHITSFKGLSLRHANDLNCYKKFFSESTVEFSFKPNVDLRQLIKSHDIRFQPEKLSLERGSWIAFDKLQTASTQSLRLSENEWLNKNWPSLKTVELGENLMKGYAQEFWKSAPEDQLEGVCCNCKSCEYDDSSFLDFTKMNSVKFYGWKSSSSIEYYLVLKSSECRESLLSETENQMVKIPSYISKLPSLKTVAFSDRLYWVKHYDRTMELIPVFEDFGTSSIYLSEAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY25</accession>
    <name>G3AY25_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_102253</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY25"/>
    <dbReference type="STRING" id="590646.G3AY25"/>
    <dbReference type="GeneID" id="18245539"/>
    <dbReference type="KEGG" id="cten:18245539"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_1_1_1"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="163" mass="16839" checksum="1D770F2652EC68B7" modified="2011-11-16" version="1">MSEVLAQEYTPGFAPFFGFAGCAVAMVLSCAGAAIGTAKSGIGISGIGTFKPELIMRSLIPVVMSGILAVYGLVVAVLIAGGLDPSQDYTLFKGFMHLACGLSVGFACLASGYSIGIVGDEGVRQFMHQPRLFVGIVLILIFAEVLGLYGLIIALILNTKGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYG3</accession>
    <name>G3AYG3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_129299</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYG3"/>
    <dbReference type="STRING" id="590646.G3AYG3"/>
    <dbReference type="eggNOG" id="KOG2043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002149_0_0_1"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031906">
        <property type="entry name" value="RTT107_BRCT_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16771">
        <property type="entry name" value="RTT107_BRCT_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="90"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="209"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="309"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="709"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="810" mass="92070" checksum="B843E73611A11C9C" modified="2011-11-16" version="1">MFKGLNALIVKSEGFQDPKKVDRLQLSIENNGGITYIKNAHDSEDYLEKTQEFIEYSTARDSMIPITTPDWVHKSTATGKALHVTKFNPDPKSFLKECFICIGDDIPNSDKEIIYGGVKAFGGMYLDMLTSYTTHLITTDLENDKSILACSSEVDIKIVTPNWIDDCFKMGRKVSEKEYYLEVDNLADNEQNQLIINECQANVDNMLSFNTSFFNDKKFYISADYMLSKNLRGAINALILKNGGKISSKFTDSIDTYIGKYRHGKEYNASVKNSGIIIGNLQWFYTVVLTNKWILPTNSQLLHYPIPSKPLTAFKNLKISVTNYSHEARYYLSKLITIMGGTFTKNLTKDNDFLIVGKPTGNKYYAAHDKWVVDGEQLVKTVNHLWLEECFANWQVMDHVNPKYTHLGYVSGHGVTRLIGRTKLKTKVLRDWIDFDVDDSMDDGILQPSVEEETDYSNEDEEKIQEERTEGCTKPKNRRITKQEKNKNMKKHLKSKKESLAVGVNTSTPPNKRGRSAKTKAAMKLHDDMEDLVKHQKMLKSSKNLTGYMRELEHTSSKRPNSQDKENITPVSKKQKAFTPEKTASQLSMVAIMTGCESEVDLTREDIANLKNYGIKISSGAGKINCLIAPRILRTEKFLSSLGKVDFILHPRLLIDLKYLLGRGESPEIEIQDYRLDKIISVSEANEQLGYSDEELEEVNGIEQILHSPRGQLFEGYKLNLSANLNGGFEVLSRILLSHGVEELKLVNKTISSQKNLLESDGDKILIVNKTKDAKLIKSLPKNCTFVEWDWCVKSIFKQKIEPFDKYIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYL9</accession>
    <name>G3AYL9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_92225</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYL9"/>
    <dbReference type="STRING" id="590646.G3AYL9"/>
    <dbReference type="GeneID" id="18250174"/>
    <dbReference type="KEGG" id="cten:18250174"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_5_1_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01053">
        <property type="entry name" value="LSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="554"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="887" mass="101709" checksum="5953CD68BEB9D4F5" modified="2011-11-16" version="1">MEGSLHDQERHFLTSPGAPTLTSCQVQEVASSPDIPQSTSQWRLFDMLKISSSPKLKEKPIEPTKQHTDPANDIIVSNCICCATLLSHPQISSKFECSICHTVNLLKDFQDYYMKDSHVPHTISFRYVKRVAEKCLADAHDNQHKTLHEIFEPLSNYLYTAFQNYGCVNNSFKVKKSSSKIHYSTSNINYEDIQKVFDLLTKLPTKRPLYNALQGCSTLLRRIPVSFGEDARNYCFLLIMFQIPLLSHALTHYESKSNPPCTRMIDSPEIKALCYDVIKRVLGILSNIKSVRVKNYITSWFSRYSSSDFVSKVDLINVYITFHMKKYFYIANNPEHRRKLSIPSPGNNVDEEYFQNSSFKEQIEQMNSGSSPLPTGPLNFGRTKSKKSKDSTTKIRIYQYGNDWHLKTASIVLQSFLEAYNIRADSLHVSIFYNSLVDYVNLKMDFDSWISNKKFKDQKPGDNPELSVVIDYINGNQNSFASSATFFFSKYPFLITLGNKISILEYEAKRIMERKAEEAFINSLDRRVPLDVYFRVRVRRSHFVQDSLNCILANQQNLKKSLKVQFVGEAGIDAGGLRKEWFLLLTKAMLSPETGMLVNVEESNYHWFNLVPINNVDNYYLFGAVLGLAVYNSTILELNFPIAFYKMLLKIPLGFSDFEQLHPDLSRNLFKIKSLSDEELNMLDLSFEISIFDLFHNVVNRELVPDGKNIQVTSKNRDLYIEKYAKFRLTDGVAEQTDSLLKGFCSVTSGNGLSLFSPEEIQLLLCGNEEGKLDLEILRSVTKYLGWKDSEEAQNSQLINWLWEYLNELSYKEQKKFLSFVTGSDRIPATGIQNLNLTIKKAGSESERLPTAHTCFNELEIHRYATKEKLYEKLSMAIQGSSGFGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYV1</accession>
    <name>G3AYV1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_92280</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYV1"/>
    <dbReference type="STRING" id="590646.G3AYV1"/>
    <dbReference type="GeneID" id="18250178"/>
    <dbReference type="KEGG" id="cten:18250178"/>
    <dbReference type="eggNOG" id="ENOG502S4M0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261914_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013888">
        <property type="entry name" value="RNase_P_Rpm2_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08579">
        <property type="entry name" value="RPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1136" mass="132592" checksum="DD6D9B68A05F2759" modified="2011-11-16" version="1">MVFCSFIRCKYYPVHIKFFQSSSSYLHNQSLTRFYRKYTRIYKDHDPHPSRQSNSYLNISAGHYGLYFTIFNRDAEKHSSNSIDIISFDPQLQFMSPTTPSVFTKFHISGLNQHMYNNMSELKSQSKSLRSPSSLVSKRAFSTFVSSNGAQASSPLVTSVEDAHKSEPLEYDDFESFKTTQISKINSLFEEEDYNLIFPIYQSLKRNHMGLGSTELYNKVLSSLLLREFDNSMQLEDIEIRLTNLLTVYQDFLFFANEQMKPDFSTYNIVIGGLLKGSLDSVTYNKSKNLPTILYNQSFIKSQEFALIALELLHSVKDVQQLDLNKIYPLKFEVLNQFPNLVNKELMTLVFNNLLKNTDQFQYYNQLIRLTSKFQSTGVLNSDEDCYNFIFHVYNSYQEMAVGSFTKEQDYIVYESLVTELIKINNLEVATKFLDSILLSFKSSYKAEDKEGISNLLSGYLSEISNHNLTEAYKLMKEFNAVNFIPELSMSLNNELIDKFIGYYYSLETSKNNANYESVCAQQQDVYYNIWDIVNYNLIRQDFQLNHGLISLVVDLNDYDNIYKLTKILLINEELIDLQAFKKLLDYFASGMSYNFNTYYELILKLIEHQAQFYNDYGKINDYFSEVVDYLTISSNEFVVHNLINSPLIEEVFDKSDLVDDKIYGLIKFSKFLLDFFETNEVLEEDLLKILNYQSILINQLEDPDLTYVNLDEDLGNFKTRLSQSFGTNQSLLGQQTKSMIQSCKYLDIEVSDKPVVKVVPTVNLVPLLNINYGLGVKKFIEHFNQGYKFDDQTLFALISKEFLVNHLKRINVNKFVKLYISAGNSDLVETLVNENLDKINIAILKNIESMDDGLFSLYLDKLLMSSNKYLFEVFNSIDYTLDDIQMGKYLQLLMKHEQYQQIVDIFECNDELVNNESNLAVYLNSLLVTKQNDKFNLLVKSRFNSRESLQRLLENHDLKMVVDDYYLLSNFESNLFAPQKFKDVKDLTNQIFNQLSNEKNLRELYQLNSKLINVNQQMVISRLLAKIRDYKLGYDLLFKFCQISNIHKFSVLNLKRIIETLTKFEDVVKLNVIFNKFLHKNMSSYLKFEFFEILITSNKDKVELLKLFKNSFASLNCEINLIKIDKFVIENNISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ24</accession>
    <name>G3AZ24_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_133418</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ24"/>
    <dbReference type="STRING" id="590646.G3AZ24"/>
    <dbReference type="eggNOG" id="ENOG502QT8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_323371_0_0_1"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="STB6-like N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="962"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="766"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="964"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="989" mass="113831" checksum="AB7864AB8CC60AA4" modified="2011-11-16" version="1">MAPTKEFDPPRDEELLPSVPLPELITYILPDFSAFKHFQRDFEQSNEFHLIEYTKTTGFDIYLVEQWVNNRSIGSLISTYTGNTNNEVRVVKLTVVKKPSKFYPIRFQEYLSELVTNHAKLKQMNLPPEDSENQESEVRNPSVGGSNEEYLFITNITSLPSHLSLIPILGGDIRVVEDEFVVNSNLKRLRCSGRSISLITPKISDANEDKFRRMYRIYNLNVPIKFAVRELINIIQTCLFYFDLLDARYCDGLLCNKTEEAIINWWNLIGLPHFNIRPNHSDGILPSRTVAAIISLTISIKIRLQIFGGCDVPKDPFDFENFMISIGEFQRQVKLEKKRKLDIETLGKLFYITSQKINPDREKHKIDYEAGDISIENISTNSFATGAIFPSTPQKKNKSYTKEIRKLTSAVKNTVQDRISTVNKPDDGIKTEASPNKTSGRLRERLAKLGESSNPSEVETLNLELLVNNHLVGRTLKRLWYGLSEHKTDASLLLDKDPSVRKDLLTSPRLTSVRSFDHHSHHPTSPTQMTRPQSPPNHGHGSHHHSHLDPHGSHHHSTNKLYKFVSLRDSIANTQKIYYETSRYSRGLNRMKLGLQRNLLLPQQKKLYPNASALRRSHTQKFNPNLINSLSTVDALLKIPSDNSDDAKKPNFIIKEQPPKKCSAPNSQDIIVRFDKGLNRRNSFPFVQDSGETNLNLLELTYEGGAEICKKSTLVRRHSHSILQEYDSDLITLEKVSVNYLNDMKCLIESDIYKKSLQEENSGMNNSTLEKKYKNLDSDLQKLKSNNKQLCTSKAKLHNEDLPSVIEANMRNLSPNIDRLVYESRIIIKRINELEQNSKILKAKSKDQSYTKINNIVNDLIYSHRFHRVFKNQEERTEILLKLTGGNEEMVQMVEREINHEEESAGFFRIFVMFLWEMIILIFQLFKFDRSKMNLDRIRQTWVKLDPNRKYINRAYEFVGYEPTGSSESGSRSSRRGSTFSSSGTVNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ70</accession>
    <name>G3AZ70_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112882</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ70"/>
    <dbReference type="STRING" id="590646.G3AZ70"/>
    <dbReference type="GeneID" id="18246720"/>
    <dbReference type="KEGG" id="cten:18246720"/>
    <dbReference type="eggNOG" id="KOG2944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_0_0_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="162"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="324" mass="37026" checksum="C5AA9C41C950E1AC" modified="2011-11-16" version="1">MTTIDNSFIINHSCLRVKDPKVSIPFYENNFGMKCIRRLHFDGFSLYLLGFETEANKDKSWGAREGVLELCHNHGSEDDDSFKVNNGNGTENRGFGHICVSVDNIQVCEANLLANGAKFQKKLSDGRQKDIAFVLDPDGYWVELVEHQRNKTEAKTDLSTYKFNHTMIRVKDAKKSLDFYKNKFGMKLLSTFDFPDARFTLFFLGYDHANNHEENSIDKKVRHFQESLLELTYNYGTEEDTDFHYHNGNSTDNGAIQGYGHIGVSCKDPATFCKQLEDKYGDELDWSVQWGKGSLTPNLAFIRDPDGYSVEIIPLDIFSDDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZB8</accession>
    <name>G3AZB8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112918</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZB8"/>
    <dbReference type="STRING" id="590646.G3AZB8"/>
    <dbReference type="GeneID" id="18246735"/>
    <dbReference type="KEGG" id="cten:18246735"/>
    <dbReference type="eggNOG" id="ENOG502QT02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_6_2_1"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="48990" checksum="F612C465742A01BB" modified="2011-11-16" version="1">MAANSLQPAQHHHSFTESDVETENTKLDSHASPPQKPYSSWNRLHHKASHKLVNNFLPAYFVNVMATGISAAICYHFPYPAAWLRVVGLILWALGIFFFLCGTVLMVISASTVRGNLVKFHTDPKVAPFMGCFAMGYNSMVNMLYFVTGPSFIIGIFVLWWVSVFLCVYTAVVIFYFTFLVKTSTKKHFSPENFHATLLLPIVALTVTSSAGQLFAMDLPHRNLQVLTVVVSYVLWANAMAMSFIVLSLIFYKYLVHKIPNTTMVFTTFIPIGFLGQGAFSILLCGNNLHQLVPAMAAKLAGLEFTHNMGQTLSEAATSIATVLMVVCSLTGLFLISFGYFNTCIAVASVLTKVLTKNPNPEHVCTSGPFEGMIRFNKGFWAMTFPLGTMAISNSELGKMYGMETFKAVGAVYGVATVVVTVGCCLGFLYHLARDVVECFTEEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZD7</accession>
    <name>G3AZD7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Increased loss of mitochondrial DNA protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_101352</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684644.1">
        <property type="nucleotide sequence ID" value="XM_006684581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZD7"/>
    <dbReference type="GeneID" id="18245462"/>
    <dbReference type="KEGG" id="cten:18245462"/>
    <dbReference type="eggNOG" id="ENOG502RZTE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117796_1_0_1"/>
    <dbReference type="OrthoDB" id="5299849at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19228" checksum="672A211027AC42E4" modified="2011-11-16" version="1">MKFLTSRSLIYIRTIFLFTGAFWVSTDPKSLIHSNFVLLLAEAMQLPIIPVDKKSPSNGLIAMFMTITALSDLIPCMADNVQYFETVVPTRLFGFFCLCAYTYLIEDRIFSNSVVFVYSFLEIWLNLLIFNNLRDEKYVRLKEYINEHGEEMQQEASEHVRVIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZF8</accession>
    <name>G3AZF8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E set domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112947</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZF8"/>
    <dbReference type="STRING" id="590646.G3AZF8"/>
    <dbReference type="eggNOG" id="KOG3205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138077_0_0_1"/>
    <dbReference type="OrthoDB" id="4005750at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="162" mass="18486" checksum="ECF0BB2ED038D1AC" modified="2011-11-16" version="1">MSKNTIKSRDELLDMFRNELIELIAMTIQCEGHPEVLEYSQEMENIPQKLFFILPEYSTYTLTIKYRVTAKPLVKLTYYQVVKKGGIPFKSRKEEIANTAVTNDDTNPHHTVTFPPDDIPGGTFIRGTYPAVSTFYAEGKPIFSTEWAIKVVKRGTQPSIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZL5</accession>
    <name>G3AZL5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphotransferase</fullName>
            <ecNumber evidence="14">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_112485</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573</strain>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="14"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZL5"/>
    <dbReference type="STRING" id="590646.G3AZL5"/>
    <dbReference type="GeneID" id="18246540"/>
    <dbReference type="KEGG" id="cten:18246540"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24087">
        <property type="entry name" value="ASKHA_NBD_HK1-2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="15">
        <location>
            <begin position="27"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="16">
        <location>
            <begin position="226"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV66103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="481" mass="52922" checksum="E3FDA81D0AB1BFE5" modified="2011-11-16" version="1">MVHLGPKRPQHRKGTFTDVPEQWMEQLHEIENLLTVSAETLRTITTHFVSELEKGLSKAGGNIPMIPAWVMDTPTGKETGDYLAIDLGGTNLRVVLVRLAGDCTFDTTQSKFALPESFRTGSADQLFDFIADSLAKFVEEQYPEGCSEPLPLGFTFSYPCSQSKINSGILQRWTKGFDIDNVEGHDVVPMLQASIKKVGVPIDVVALINDTTGTLVASMYTDPEAKMGLIFGTGCNGAYYDVVGDIPKLEGKFPSDIPATSLMAINCEYGAFDNEHAVLPRTKYDVQIDAESPRPGQQSFEKMISGYYLGEVLRLVLLDLAEEKGLFFKGQDLSKLHKPFIMDTSFPAHIEDDPFENLSDVQELFDTVLGIQVTLPERKVIRRLAELIGERSARLSVCGIAAICKKRNYKKAHCAADGSVYNKYPQFKERAAKALRDIFEWTEDEDPVVIIPAEDGSGVGAAVIAALTEKRLANGLSVGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZV5</accession>
    <name>G3AZV5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_112989</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684936.1">
        <property type="nucleotide sequence ID" value="XM_006684873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZV5"/>
    <dbReference type="GeneID" id="18246770"/>
    <dbReference type="KEGG" id="cten:18246770"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_4_0_1"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="138"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="243"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="334" mass="37077" checksum="240D01AB53E52A64" modified="2011-11-16" version="1">MTHVDPKPSSQTPSGGIPAITGSINHTNAIHVFPEHLQPWKPTVISYGSSFLSTTIGFPMDTIKTRMQTHPEFKSYFDCALKTYKAEGINGFFRGIWAPLVSSSFSKSINVSLFTQCKPYVHNGLFPYDDSDIHPFVRNIPTCFLSGMVAGAGVSVFACPFEFTKIFAQISKLVERNTVSKASNGSTLATFKKIIKYEGPMGLYSGFRYHIVRDALSSGVYYSVYETMKYTMNTVINKDATKNSPISVVLAGGLSGVTCWIVVFPIDTAKSLLQKQVVSNIFCKKDRLQPKPVKRPKITISRNMYRGLGISVTRSFIVNMVFFSTFEFLMGHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZX2</accession>
    <name>G3AZX2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_129554</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZX2"/>
    <dbReference type="STRING" id="590646.G3AZX2"/>
    <dbReference type="GeneID" id="18249388"/>
    <dbReference type="KEGG" id="cten:18249388"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021752_0_0_1"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="274"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="163"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="663" mass="75797" checksum="C0A5DE9669AF977F" modified="2011-11-16" version="1">MNHDDDLTASHWDDILSPSTHTSYNAASSTYLDPEFNGFQDLSLGDPDNTTTHHDDTEPESSEEDSHQAPSAHHEVQESSYAVDSVTESPNYNHSSAYDTARSELEQMHELKKEERAKQKSKLMDELASNDDFDHQLEQSVMAATPGDNFDSLFNDAKSPIKFDLSADVKSKNGKSKQFKRPRKFSSQKNAKNLKSTPAKENENLGPLGSTDNKSTDNLSMKSANAKEELVKESEAPLYDLSKDAQREQQARTPAAIAAIKAHNGEHDPSKPKNHLEITVGDPMKVGDITNAHIVYRITTKNKNLEPSTFPQQTEPFIVTRRYKDFRWIYHQLQNNHMGRIIPPPPSKQTYIGRFNESFIENRRLSLEKMLSKTSSIPDLSNDPDFIMFLTSEDFANESKERERISGSGASLQNNDMLDNPADTSSANNGFMSSIFSISNKPQEPEEFFDTKKHYIEALESNLQNFYSAIELIINQRIDIVNIIEQITVAIQELTDLEISKKTSDTLAAFNEVQIKLKDNLDRVNLQDHLTLGFTIEEYLRIIGSIKYVFDQRLTIYESYQNNLSDLNKKKTSLTKYKSRNQVDKISQLNFEIDKLQTKTDSFEKRFKTISDTIKQELENFELEKIDDFRNSVEIFIESSIESQKESIELWETFYERQSLSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZX5</accession>
    <name>G3AZX5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">homocitrate synthase</fullName>
            <ecNumber evidence="6">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_113002</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="6"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZX5"/>
    <dbReference type="STRING" id="590646.G3AZX5"/>
    <dbReference type="GeneID" id="18246775"/>
    <dbReference type="KEGG" id="cten:18246775"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_2_2_1"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV65265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="405" mass="44791" checksum="1A05DF072598C4C4" modified="2011-11-16" version="1">MSSNPYGPNPSDYLSNVSSFELIESTLREGEQFANAFFTTEKKIEIAKALDDFGVDYIELTSPVASEQSRRDCEAICKLGLKAKILTHIRCHMDDARVAVETGVDGVDVVIGTSSFLRQYSHGKDMNYIAQSAVEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGGANPRQVYELVKTLKSVVSCDIECHFHNDTGCAIANAYTALEGGAKLIDVSVLGIGERNGITPLGGLMARMITANRDYVLSKYKLHKLRDLENLVADAVQVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILNPSDFGLTRYIHFANRLTGWNAIKSRVDQLKLDLTDEQCKEVTAKIKQLGDVRQLNIDDVDSIIKEYHSSIDDNKEPDAKKQKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B053</accession>
    <name>G3B053_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_129595</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B053"/>
    <dbReference type="HOGENOM" id="CLU_094334_2_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022592">
        <property type="entry name" value="Nucleolar_19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10863">
        <property type="entry name" value="NOP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="162" mass="18175" checksum="7805EC45A9D5AED1" modified="2011-11-16" version="1">MSRREEIKKKELLQLQFQQQLQHNTTMIQSWLPSSSQKMAPKPRQQFFDLPIIESGKSLNSIAEANETQRLGEFLDADSHKAFSRNKANGPPSGAMNTLMNKIKSDRRKKTETIRTPIGKNRVKPLAPIVNVGGTASASDSDSDADLRSDNRPTTKKPKLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0E8</accession>
    <name>G3B0E8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113106</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0E8"/>
    <dbReference type="HOGENOM" id="CLU_2721980_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="72" mass="8071" checksum="206E6A338F5E9700" modified="2011-11-16" version="1">MGGALPYASSNGSESGLRSRGLLYMFSLSGHRSTCAHQLPIDVTSNAKAYYRKRKFQNRRLRIFAISTPYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0F7</accession>
    <name>G3B0F7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_102877</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0F7"/>
    <dbReference type="STRING" id="590646.G3B0F7"/>
    <dbReference type="GeneID" id="18245589"/>
    <dbReference type="KEGG" id="cten:18245589"/>
    <dbReference type="eggNOG" id="ENOG502RYK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052853_0_0_1"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="304" mass="34482" checksum="5F04F6F6481344CB" modified="2011-11-16" version="1">MAPPSHHLHPQAPAQQAQQPPTGGINSVLEYDLTNMSTFLSWCAFGMLKQNRNPTKDFEGLVNSVLFATRLPKSTIIIALEYMNQRFSSKGINTLSESEIFIKLIVGLILGNKFNDDNTFTNRSWCGATGLQISVLNEEEMTWLQEVKWNLNVVNFESNIITLEECWKTWLEKYTPKDVSVSTYSSPVYSNPSIPSSPVSPDYNVYYPSSSPTLPYSNSSPTKYSDAMWNPQQPVPHLAVQSLPSNANVNHHQHQHQHQHQNSIWSYTPNYPNNLPISHQPIQYLNSNFVGYTNPYYTFNMASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0K4</accession>
    <name>G3B0K4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="12">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_113173</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573</strain>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="12">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="12"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0K4"/>
    <dbReference type="STRING" id="590646.G3B0K4"/>
    <dbReference type="GeneID" id="18246841"/>
    <dbReference type="KEGG" id="cten:18246841"/>
    <dbReference type="eggNOG" id="KOG1506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_0_1_1"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="15">
        <location>
            <begin position="120"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="16">
        <location>
            <begin position="242"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV65554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="385" mass="42093" checksum="9F6583AE64CBD77E" modified="2011-11-16" version="1">MSATEERFLFTSESVGEGHPDKICDQVSDAILDACLAADPLSKVACETAAKTGMIMVFGEITTKAQLDYQKIVRDTIKHIGYDDSSKGFDYKTCNVLVAIEQQSPDIAQGLHYEKALEDLGAGDQGIMFGYATDETEEKLPLTILLAHKLNAALASARRSGELAWLRPDTKTQVTIEYKNEGGAVTPLRVDTVVISTQHAEEISTEDLRSEIIAKIVNKVIPANLLDDKTVYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVNAQLAKRALVQFSYAIGVAEPLSIHVDTYGTSKYSSEELVAIIKKNFDLRPGVIVRELDLARPIYFKTASYGHFTNQENPWEQPKELKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0W2</accession>
    <name>G3B0W2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_134124</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0W2"/>
    <dbReference type="STRING" id="590646.G3B0W2"/>
    <dbReference type="eggNOG" id="ENOG502QX5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027584_0_0_1"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="399"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="487" mass="55326" checksum="5E6A5B4EA31AE96D" modified="2011-11-16" version="1">MSVETSMYNNQIDPSFQPAHLRSGSFNELLNSFKQSVSSEQTRLRSRKRSYNDLIRTDSDASIEPIDNVANKRSKTAPPQSPSPVSAKTVEVIDVFDKNTIKRPRSLSPSKKTRSPTPSSPTLHTRKSSNKVTKPQVEKTKKSNVTLPSFSTVLRENVENLKPITPTTSLDYFDTYKPNDENWRYGLLDTMTKNKTYNMNHYTVSNNHARPVFDSKISKPILPPISFEPERKINFPYESNYTYLNQTYLYDVEKYPEYLELAESLVQLSNSSTMPYHRVSKPAHFPPLYPHQVVEPTSPKDNEEAAFERQQREQRAYEQQHYHQQYLPPYQSSYPPYPAFMASPSATVVNILPPSAYPTYIPEQPVTPPKKHTKFIPITPPSSKSTKSKAEPLKSPTKNHPPRVCISCGSDQSPCWRPSWSSKEGQLCNSCGLRYKKTSARCLNNSCKKIPAKGEWSLMQTKGVTTFDDGSEGYGCLECGNKVEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B190</accession>
    <name>G3B190_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113669</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685980.1">
        <property type="nucleotide sequence ID" value="XM_006685917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B190"/>
    <dbReference type="STRING" id="590646.G3B190"/>
    <dbReference type="GeneID" id="18247076"/>
    <dbReference type="KEGG" id="cten:18247076"/>
    <dbReference type="eggNOG" id="ENOG502S52G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100674_2_0_1"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="198" mass="22171" checksum="8A1B5C03FAD1C1D2" modified="2011-11-16" version="1">MLRQLTRSSNMLSFRGSSMGLVRSLTTKTSIVEHTTGRIITLTDPNRPEIGDYPNPPPVLAQSKDPYAKYDDQQNRRNFNDPVNIDDDYYDMWSPDYFQPVSDKTALKHNGVFFGLFISFGAVIAYFQLNPEKPAMPRSFPGNGLAKSLGSGSDEDDGFYQVKPDLEAEKELGFLPADGDLSASIESYKKTHADFIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1C5</accession>
    <name>G3B1C5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_121150</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1C5"/>
    <dbReference type="STRING" id="590646.G3B1C5"/>
    <dbReference type="GeneID" id="18248827"/>
    <dbReference type="KEGG" id="cten:18248827"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_0_0_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000053">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000156">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="435"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="135"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="210"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="768" mass="87455" checksum="D7766BE861634EC0" modified="2011-11-16" version="1">MSSSRTSPISVKVVAAESLYKRDVFRQPDPFAVITVDGSQTKTTKTAKKTLNPYWNESFKFSSSEDSILVIQVFDQKKFKKKDQGFLGVVNIRIGDVIDLSLPNSEETITRDLKKSNENLAVSGKIIVVISHNPSGANGASSSPRSSALANGSTTPTPGPPPAAGTASAAGTAANKQYSSFEDQYGRLPPGWERRTDNFGRTYYVDHNSRTTTWQRPNLDQSETERGQQREDTTEAERRQHRDRTLPGESSAGSSATSGNVTVNASGANTPVSPAAAVSMAATGATTSGLGELPSGWEQRFTNEGRPYFVDHNTRTTTWVDPRRQQYIRTFGPNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKVIYFRSQPALRILPGQCHITVRRDHIFEDSYQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHDMFNPFYCLFEYSSHDNYTLQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEFYRSLKWILDNDITDVLDLTFSAEDERFGEIVEVDLKEDGRNIEVTEENKHEYVEFITEWKIYKRVEEQFKAFISGFNELIPQELVNVFDERELELLIGGLAEIDVEDWKKHTDYRGYQESDQVIQWFWQCIKEWDSEQKARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGESNQLPKSHTCFNRVDLPPYTDYESLKQKLTLAVEETVGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1E7</accession>
    <name>G3B1E7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_104283</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1E7"/>
    <dbReference type="STRING" id="590646.G3B1E7"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_927850_0_0_1"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="267" mass="31084" checksum="D9EFDC98B1156684" modified="2011-11-16" version="1">MLQFLRLNHSKAGTLYEVLELPRTCSLTEIKLQFKKLSKKYHPDLNNHLEDEDKKVNSDQFMKIVDAYETLKDKHKKAEYDRSLSTNEWENSYYGESRNSGGSRLNRTRHRVHSFNDTDESTSTFSGEHKNYGDRFNVPHFNYNEHLSKHLKFEQRIINKKLTKQERDAILQQLTKNADLSDVSEELITKHLMRQVNRKAKGESILYRSTSNMSSSNPFMYQKPSTVQYGVHENETDYDDGSTLKAMVIIGGTTGSLFLALKWYLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1W6</accession>
    <name>G3B1W6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-arabinose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_120152</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1W6"/>
    <dbReference type="STRING" id="590646.G3B1W6"/>
    <dbReference type="GeneID" id="18248756"/>
    <dbReference type="KEGG" id="cten:18248756"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="325" mass="36713" checksum="86ACE921A0896AA2" modified="2011-11-16" version="1">MIKYDLSTDVKITLNDGNVMPTLGLGTVHEGDAPDVKNQVVAAVRAGYRHIDTAWYYGSEKYVGEALKQIQEEGIAKREDLFITTKVWPSFHHHPERSIDDSLKELGIDYIDMVLQHWPICLSGDANGLPPTPFDNKGKLIYDDDPVNGTGYIKFYNRLEDYKFNTEKVKSIGVSNYSISRLELLLKNRKRYIPVVNQIEYHPQLPQKDLVNFCENNGIIVEAYSPLGGTGAPVLRAPMINELAAKYQVSPNEIAIAYHILEGRSVLIRSSNLGRIKTNIKLPPLTLEELASLYDVGVKRPTRYTNDPWGYGLGFKWWEGDTLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1X4</accession>
    <name>G3B1X4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_92786</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685358.1">
        <property type="nucleotide sequence ID" value="XM_006685295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1X4"/>
    <dbReference type="STRING" id="590646.G3B1X4"/>
    <dbReference type="GeneID" id="18250230"/>
    <dbReference type="KEGG" id="cten:18250230"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="32"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="483" mass="54168" checksum="E82B06B7F712E1CF" modified="2011-11-16" version="1">MTGKKHIILNAFDMGSSGHQAPGLWKHPKDRSNDFDKLEYWTNLAKLLEKGKFNALFIADVLGGYDVYEGNLDAALKSGAQVPLIEPGSLIPAMAAVTDHLAFAVTFSTISEAPFHFARRLATIDELSKGRVGWNIVSSYLESAATNLLNGEPLPPHDERYARAEEYLDVVYKLFLSSWRDDAVVLDKENGIFTDPERVRKINHDGNWFKVPGPNIFRPSQHQRLPVILQAGTSRAGKEFAAKHAEAVFINSFTPEDLKAKIHDIKTIAKEKFGREEDSIKFLNLLTIVVGETKQDALEKFKDYSKYGDLDGSQALFGGWTGIDLSEYDYDEELTNVESNAIRAAVNNWTKRSPGDPPNLKKTRRYVAEKITVGGLGPVIIGDAQSVADELERWVEISGVDGFNLTYTISPGSFEDIVELLVPELQKRGLVWDDYPDDVSTYRESLFGTKGPDPKFVRPSHPAYKLRWKEGESKEDFERRINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B226</accession>
    <name>G3B226_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_120265</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B226"/>
    <dbReference type="STRING" id="590646.G3B226"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020128_0_0_1"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="588" mass="67511" checksum="25B65B52326CEE41" modified="2011-11-16" version="1">MDIDSNTSHVKSSSNETNGSKSEPEVVEVSLHSESKQPVKDSNVNISDTIAETSGRLIILYDKPKYKHVRKQVEQLSILGETDIFEVNDFGSFEASEIKNKNYRYLNICIEYNDEFESNLRKLNEFLLEHNSFVSQFKEIGYHVHFDNKKWSEYTEFEREEYSKLIESLMQHKDKVTQVSIINKYEINTIYLTEKNDLTKLGEEIQDDIKNWQNLKVLDYGENCIRFFPGVKFPDSLEVMNISGSYCIETLTGFKMPDNLKVLIASHNSITSIDNLKLPSNLTTLDLCDNKIYFLNYTEFPDSLRSLNLSNNRIDNIRGIEFPRNLEFLALAFNPIDNIKGSKFPENLKYLDISCIPSDSMTGLKFPDSLETLNLQESMTNTRGLKLPNFLKHLNLGNNGVNSINPLKLPNTIETLYIGGNNIKTLNKVQFPMHLRELYLGNNYLTTLKNVVFPPGLEVLDIEMDPNVEENDKRIGTLKDVIFPPQLRVLKLGYQGIKILENFEFPPSLEELDLSYNDLKLIKNVKFHENLKSLNLSGNQELIEIDQVLIPNSLVDLKIPSQLIPNLPGYIIERANNKDLIITKSLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2Q5</accession>
    <name>G3B2Q5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113515</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2Q5"/>
    <dbReference type="GeneID" id="18246999"/>
    <dbReference type="KEGG" id="cten:18246999"/>
    <dbReference type="eggNOG" id="ENOG502RJPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024079_2_0_1"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053102">
        <property type="entry name" value="VPS_Associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48220:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442496" description="Vacuolar protein sorting-associated protein 62" evidence="1">
        <location>
            <begin position="22"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="50832" checksum="E26E57F41219C2E4" modified="2011-11-16" version="1">MIAPSAVISLCWLVLSTSVAASAVPYWQIDKGYIHETLTKDTANINSMLRKAPGQFRHLPPIVDNPTPFQRSIQDGEVPDYILEYAPVVHLYSEERYLPYDIGKFVTHFHVEYDNGTTVPGTEANMNLKKLSELPEEEDYFLTSNSDFDSDPEWITGIKNKPSLATGEIKDAPAVLIVVDKGNGWVDAYWFYFYSFNLGPFVMGSGPYGNHVGDWEHSLVRYYNGEPVIVWMSAHGGGQAFYYHNLEKYESNPNHPILFSARGTHANYVSVGQHPHDLPYAILSDFTDRGPLWNPTKNYLAYTFDGTRVYPATTNRNPHHVGREKKYHNWLKFWGRWGDRKLPDDDNRQRYSFIGGYKYIDGPRGPLMKNLLRIKPCERHKWWNFWAGCNVRQNIKWGIGVESEGYNCGNVFISIKPNWLRKIIQHVTWGGFFCYAADIFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2U5</accession>
    <name>G3B2U5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113539</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2U5"/>
    <dbReference type="STRING" id="590646.G3B2U5"/>
    <dbReference type="eggNOG" id="ENOG502S7AZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162803_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="13581" checksum="FAB1BCE94A03CA03" modified="2011-11-16" version="1">MSGKDYSAPTGAPPEWSNSKPSDNYAPPSHPPSGQSAGDRGFGGNQQGYGGQQGYGQQGYGGQQGYGGGYQQQQGYPQQGYGGGYPQQPQGGYYQQQQPMYVQQQSGGSGSGGCLAACLGALCICCTLDALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B385</accession>
    <name>G3B385_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114139</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B385"/>
    <dbReference type="STRING" id="590646.G3B385"/>
    <dbReference type="GeneID" id="18247282"/>
    <dbReference type="KEGG" id="cten:18247282"/>
    <dbReference type="eggNOG" id="KOG3856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093901_0_0_1"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="138" mass="15877" checksum="F71336F5692E2FCB" modified="2011-11-16" version="1" fragment="single">MADKDEYTTLKTQLTKEILKKQELSNKLTKLEDLIYDRENEYFNESAYGNIVKGFENFSKNTSNNNKKRIIYTEEDHIFSLASTQYIKSLMKRQGQSLKEDYDDYEDGVEPPDANGVAVHTPGSVGGTPGRKRKIRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3E6</accession>
    <name>G3B3E6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S19/S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114179</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3E6"/>
    <dbReference type="STRING" id="590646.G3B3E6"/>
    <dbReference type="GeneID" id="18247304"/>
    <dbReference type="KEGG" id="cten:18247304"/>
    <dbReference type="eggNOG" id="KOG0899">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_1_0_1"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="90" mass="10064" checksum="5AC946A187EECE80" modified="2011-11-16" version="1">MRVSLSLLGRSAWKGPHVVPLPISEAIKTGAPIRTNARSCTIIPQFVGLKFQVHNGKEYVQLEISDDMVGNKLGEFVATRKKFTYKYSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3G7</accession>
    <name>G3B3G7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_134734</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686472.1">
        <property type="nucleotide sequence ID" value="XM_006686409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3G7"/>
    <dbReference type="STRING" id="590646.G3B3G7"/>
    <dbReference type="GeneID" id="18249812"/>
    <dbReference type="KEGG" id="cten:18249812"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_4_1"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF119">
        <property type="entry name" value="ROA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1018"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1057"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1094"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1127"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1160"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1239"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="30"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="681"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1265" mass="142144" checksum="2E9831E387DF1DC2" modified="2011-11-16" version="1">MSYDVLRIDPSERVSLKVRKLSVAVKLRKRQAKDVESMVGDEVGSSHILQNISFDLPQNEMMAIMGGSGSGKTTLLNTLSQRLNVTNKKLEFSGSVNFYKREHLVEPHHHIRNSYLLQDDFFAPGLTTWEFLKFQADLQLNKTSKQQKADLINQLLEILEISHLKHKVISTFTSHINFSGGERRRVSIAAQLLKRPSVLFLDEPTTGLDTSSSLKLIQVLRQLSSSTLGVTVVLSIHQPRPEILELFDKICLLTRGGRLVYYGSLAYSYDYFMKLNLLSTASQAQPSAYIDRIMALSVKDSSSRENELKTAQKIAQLVECWSDEHLEPVSPVDFGTNLKVFETPRNMKISLVSEIWVLTKRTFIMTYRDHYGLGSMVGISLTMATICGWIFYKPHPDLAGIRSYTSSLYVMMEILGFLPLFIEIERLWEYDGLLFFREYTENQVSIIGFIVSRKLGKLLLEDTTICLGFGFISYFMFGLRLSVELGGATTLHYFWNYLAVTVLIYLCGMSSALAFFAISSSFPICAIYQNVFYQLQNSACGYFINAATMPVYVRWTKYICYFWYGFGALTSNQYTNWEGACPYDDEARCREYTGRYQLDVLGFPENWIAVPISILVAWYWGFNVLAAIGFKFRNYDVSMAKQKQNTIGDEEETHTTTFSEKDVAPTPTHDLDNEERQDVNLQLDGIVLDALSPVLALKKQQPYRILDTITANFDHNCVNVIMGPSGSGKTSLLNFISNRLSKSSRFQVQGSIKLNGVQTITSSQLSKISGYVTQYDSSLIPHLTVRETFYYQARLRLPAPQHSRIPVVINTLIRQMGLVDCADTLIGNEFLKGVSGGERRRVSIGIQLLSRPKVLFLDEPTSGLDSTTSVSILNLLQNLTREHGTTIITTIHQPSEAIFAQFGSLLLLGRGGHVIYTGASSGAEAYLQTVGFHKPAGVNTADYILDLVSHGIDEDKETASLRITKLVQEWQVRAEVDFAAGAMVDVKRLRKLQLPLRTRFRAIFARQLLSSFRSRDALFSRSFQVVALAVVHTLFFAPLKNTKEGIDNRLGLIQEVLNFYFIGLINNFSIFPIERDIFFSEYRDGIYNNLEFQVVYLVIESAVELITCVIFSALIVFVVGLPRTPATFFGMLLTCFASINVGESLGIIVNCVLAHVGLAMNILSSIIILAVFMGGTMALYMPQFFRAWNYINPLKYGVGICAELSFRGLHFRCDEGCSLSSGDAVLDYYGLANHLPTSVGALVGCLVVYRLLAVMACEVKIRKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3I3</accession>
    <name>G3B3I3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_105373</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3I3"/>
    <dbReference type="STRING" id="590646.G3B3I3"/>
    <dbReference type="GeneID" id="18245806"/>
    <dbReference type="KEGG" id="cten:18245806"/>
    <dbReference type="eggNOG" id="ENOG502SD63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153329_0_0_1"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.160">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="103" mass="11903" checksum="80F264AD7B1163A5" modified="2011-11-16" version="1" fragment="single">LENIDTHVEQILQKFQDVFDVAVIQDKSKELLAVESLAMETDALSIIRFCEDLLGITRSLRESWCLDSIKVNPVQDKQVEQAEINRIFSKFNQLTDSISKYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3L8</accession>
    <name>G3B3L8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translocation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_122481</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3L8"/>
    <dbReference type="STRING" id="590646.G3B3L8"/>
    <dbReference type="eggNOG" id="KOG0721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014210_0_0_1"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000114">
        <property type="entry name" value="SEC63 isoform 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="113"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="645" mass="72390" checksum="8ACF274711BD3418" modified="2011-11-16" version="1">MASEYIYDEEGDVWPYFVLAILTFILVPLTVKYLARIVSKSDPVSYNKSVKGSISDNHDTLKLNHNSIKTFQKAQTSDRILNKTLVVLIVGWAVVFYVATNLTKLADMSGLFDPYEILGISSSASDKQIKSHYRKMSLKFHPDKMPKDLTEVEKEAFEQAYIRLTKAYKALTDEVTRENYLKFGHPDGRQDTTHGIALPKFLVEGKFSPFMIVFYFILVGVLLPVMVGSWWSNVKSHTSKGLHVDTAALFVKYLTDKNPGKVITPFSLLDLLCGSHEIKHDFNHLSLVQIKDLLTEYMKRETNSDAKLELDKLKIVNVVPKLIVGFIEIAVVFRQSDVVLVALDLEKSIIQAVKPTGKYKDLLQLPYVDPQVVEKQTVKKLGKLFTKDVDAAEVLGIKDEVKLAKAKEVAQKIASLRIIQSEFVVPGEKVVPPVSKAHLSLKFLIKSPALKSCPDLNPDLLKDEETIEYMKDPSSINSTQPQLPFSYCPYFPNDIVNSWSGVLINQRDNKLVEGSSIIKLTNADLSNVSLDQDAWIKGNNVVIGTLNVPLTQPTPQAVGTYPFRLVLKNNAYFGVDVDLPLFLEVKHPAPSAIDKDKLMGISKKDEDSDEDKEEETENDDDDESIFTDINTDTEDEDEDETVPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3M3</accession>
    <name>G3B3M3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell division control protein 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114254</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3M3"/>
    <dbReference type="STRING" id="590646.G3B3M3"/>
    <dbReference type="GeneID" id="18247337"/>
    <dbReference type="KEGG" id="cten:18247337"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_18_1_1"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005825">
        <property type="term" value="C:half bridge of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="162" mass="18887" checksum="1AF05D97F5B16B17" modified="2011-11-16" version="1">MSSAAQAGQKRLSNLKTELLNEQKQEIREAFSLFDMNNDGCLDYHELKVAFRALGFDLSKRQVLDIIHEYDTDDRNLITYENFFQAVGEMIVNRDPLEEIRRAFRLFDDDGTGKITLRNLRRVAKELGENLTDDELRAMIDEFDLDEDGEINEQEFINICTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B490</accession>
    <name>G3B490_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_104592</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B490"/>
    <dbReference type="STRING" id="590646.G3B490"/>
    <dbReference type="GeneID" id="18245730"/>
    <dbReference type="KEGG" id="cten:18245730"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_4_1_1"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="95"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="327"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="408" mass="43107" checksum="2EAF20B80A7355AF" modified="2011-11-16" version="1">MTESLFESFESPATSPLSSQGSTQSHSGAPLWNDAGTAAETNTSTTVITTSTTMGAPLQPPSPSRESPADVPDNDSYPGTQDEILPPVSPENGNALINYRLLISSKESGCLIGQSGSVINSIRQETDTKAGISKLLAHTQERILTVSGTLDNCSKAISYFSQALIEAQQHEADAASTASAGPMPSSVEEYPHFPLRQLSIHKNIAGHSTVLRLLIPNSQMGTIIGAKGARIQRIQQVFGVSMIASKSFLPGSNERLVELQGSVPELYAALRVISRCLIEDFGGVVGTSYYVPRPRRPDVPVVAPLPVSAPAAPGTGPASDSSSSPARLVTTSMAFSKDIVGALIGKSGSRIQGVRKISGAIIGISDELEGSSERIFTISGSTYAVDKAKALLKHNLEREQQRREGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B496</accession>
    <name>G3B496_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_121786</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B496"/>
    <dbReference type="STRING" id="590646.G3B496"/>
    <dbReference type="eggNOG" id="KOG0569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="480" mass="51981" checksum="7C3013A131C18493" modified="2011-11-16" version="1">MSSFTGHLVATVAIMCLGSLQFGYHMSELNSPESIISCSVSKPGSVPFEDTWFGEHQFARCIPMSTEQVGLITSIFSIGGLIGSLYVGTVADKIGRKKTSMLHCVIYFFGSSLNGLSQNYGTLLVGRFVAGLGAGAALVVTPVFINEVSPPDAKGFLGSMNQVSVNVGILLTQVLALRWCNNNDWRWLLLTGSILAVVTLVLIFVYVDESPMWLVNKGYPHEALRGLHRLRGGEYHSVRSEVSSWSQPGEADQLLDEEMGRETANSPAPKPTAVSLDVYLKSPEFNPSKIVATGILILQQFCGINSIIFYGVSVLISIFPSHSIIINCMISVTNAVVTFVAAGFVDRLGRKPLLLTSVAFMGIATVLMGFGILTTNPLASIIGTFTYITFFAIGLGPIPFLLVGEVTQPRAKASAQSWGTTMNWVATFIVGFLFPILKSSWIGGGVYFIFTGMCILTFGFIKTQIPETKGKLSYEEVWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4I2</accession>
    <name>G3B4I2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_93344</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686151.1">
        <property type="nucleotide sequence ID" value="XM_006686088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4I2"/>
    <dbReference type="GeneID" id="18250278"/>
    <dbReference type="KEGG" id="cten:18250278"/>
    <dbReference type="eggNOG" id="ENOG502RQFI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_424502_0_0_1"/>
    <dbReference type="OrthoDB" id="4026295at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="645" mass="68491" checksum="AE0610F545AB393D" modified="2011-11-16" version="1">MAIELSEKDELLQHQLDLELNKPIQKKSRARAFANGALASFTGLLVVLYFLRQSPAVECFSPFAIFASVFAPVAPAPITVEVFEVSPDLTLSADAYVLNTTVFNQTLSDGIAFDYEAPVDFNFTGAFLTLNFSNEALVAGKPVVAEISVDDTPVWRTSTPYSKLNTITQSSTVKNVTELLSLFTEDKSISINFLEGSAAATDVVLVLSLYNDTLTAAPVAKTPITVEDILSAHGPADIIFPLTNAGKPFKLPTDSFSVTLPQLESNVTVAKVSLFASATEEEITYFKNDIGKIGEPASSGPLRYINVYVNDVYISSIAPKPALFHANEVSDNANITSLWQPLADVGAFQGLTYEVDLVSVLPFLWADDANLVVEVVSPVGAANKAPGVPPVLAHPVIPGENVITTGSWFVSGNLLAWESSLISSAVGEVLIGESSEKDSGVVVEPPMASPFAPSIKTEIVKSFIDAGIISELNFTLLDNSTANYTVEFNSSTHSILSKHSKSIKTIAGPPGSGAGTSTTTSTLTLITGIKNNFAILDVASGIAVFTKNETLDFPLNYNESAVDKKVAFVPPSTSSKLTFSIGSKAKLSINGLKTSSYKVKESASLDDIIGTTTDVKVEIETVGELPYSREVEATNGVITKDTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4V1</accession>
    <name>G3B4V1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_97903</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4V1"/>
    <dbReference type="STRING" id="590646.G3B4V1"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003502_1_0_1"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="185"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="334"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="488"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="667"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="857"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1178" mass="133745" checksum="49031E89A795F80A" modified="2011-11-16" version="1">MGKRSSVTSGHAKPRVSAAAAVDTAGSSSKPVHDSRESESEQESESDEEKPQKISHPPSKKQRKQISAQEIQVARETAELFKSNIFKLQIDELIKEVKLKDANIDKIEKVLHKLHDLIRMIPATENLTLEELEARFTSKKVVIPFPDPKPSKVNYKFSYLPPEDVSLVGSFGLKTGVSQNHGMSVDMILTMPKELFQPKDYLNYRALYKRAFYLAYLTDHLIPLTKKHNLPVKISYQYFNDDILYPCLTIESIKTDNPDDLCFHKTKFSIKLIVGLPFGVFENKKLMPNKNCIRIQSDSEELPPTPLYNSSILSSTAFDYYLKYLYTSKKATESFKDACRLGKIWLNQRGFSGSVNKGGFGHFEFAVLMSALLHGGGLNGNKILLHGFSSYQLFKGTIKYLATMDLSSGYLSFSSLIGENIASKFNPNEGFNVPTIFDKNLKLNILWKMTSYSYNLLKHDAIQTLELLNDVVKDRFDPILLHNSNHDQLRYDMLLNITIPDDLIEQFGPLEKITFLTFENFIMNKLYVILKMALGDRATQVVVKLEKFQNVFAIHKRKINSQTNNFIIGLMFNPDECEKLVTKGPDNDDHEEEVIKFRNFWGAKASLRRFKNGTIQNCVVWSIKESEPVTLSIIKYSLDHHLYKDISSNISTELPAFNKKLPIPLLPSGSNQPVISTSSFANLKTSFESLTRAISKLSLPLSVKSMFPASSSLRYTSTLQPVPFAVSNPDFWNEVILQFESSAKWPDELFALEKVKSAFLLKTLDELHKETAYKAFITQDDTIPFNSHITILRVLTPEGFGFKIRVLTERDETMYLRAVSNADKQKARAQDIYLKFNQKYIGVVKHSRTVSTLSHHFPFYSPTVRLFKIWLDSHLLLSHFSEELVELIALKPFVDPAPYSVPHSVENGFLRILEFLASWNWKDTSLILDLVKNDVGGDSYNELDSETFNKLSDKLTIQTQQMIEDNFTKIRKNDPTGIKTQFFIGSKDDPSGILWSNELTLPIASRLTALARSATEIIRSSGVNEINLNLLFVPVLQDYDFIIDIKSHKLSTSAGVLPSNSFKNLINNQTFFPDDIASKYDLTQAYIDDLNRKFGNVIIFSSHSYSFLNNDGHNIITGLFVPATLTKKKFRVNFGINLKPVQDSKDKDTEEVIINKESILDQIRLLGGDLISEVKIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B551</accession>
    <name>G3B551_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_98312</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B551"/>
    <dbReference type="STRING" id="590646.G3B551"/>
    <dbReference type="GeneID" id="18250759"/>
    <dbReference type="KEGG" id="cten:18250759"/>
    <dbReference type="eggNOG" id="ENOG502QQ2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010539_2_0_1"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="666" mass="71602" checksum="8D04589B760F5D74" modified="2011-11-16" version="1">MSISNPPRTSGSQRIPVPWHLKADIPQVTLRGTIAGLVIGTVVLISNFQFGLQTGWVSMMSLPSALLGFAIFKLSPFSNDFTDVENVYVQSIAVAVGTGPLAYGLIGIIPAMEHFLTSDESGLGRTLHFSTTDLIVWSLGLGFFGVFFAIPLRKQVIVKEKLPFPSGNATGILISVLHGTSLLEEEFKSDAPDVESNEPEEQNQVSLAANDANYKSNIRSLSITFVASAVYTIVSFFIPILKSLPVFGSYASEAFLWNLQPSPAYIGQGIIMGLPTVSYMLFGAILGWGVLSPLAKYQGWAPGEVDDWKTGSQGWIMWISLSIMISDSLVSFMVMAARSVSRLVGSARRAHSQYQPLLGDRGGDGDNASVATSYDTGLDPRHLVSDKASFVGIAVSSIICAISLKFIFGQLVPLYTILIAVVMALFFSILAVRALGETDLNPVSGIGKLSQLIFAVIVPSNHPSKILINLMAGGIAEAGAQQAGDLMQDLKAGHLLGASPKAQTIAQLTGTVYSIFLSSIMYKVYNSVYEIPSKMFRIPTAVIWIDCARLVTGEGLPPNAWVFSLVFGVIFGVISLLKNIIPKESKNHKYLFYLPSGVAVGIGIYNTPNFTLARFIGGLVTYIQMKKTGSSNQRVHMIILSSGLVLGEGLFSCFTMLLTSLGVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5T5</accession>
    <name>G3B5T5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Poly(A) polymerase</fullName>
            <ecNumber evidence="12">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_94065</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="12"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5T5"/>
    <dbReference type="STRING" id="590646.G3B5T5"/>
    <dbReference type="GeneID" id="18250356"/>
    <dbReference type="KEGG" id="cten:18250356"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="18">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="17">
        <location>
            <begin position="205"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="16">
        <location>
            <begin position="352"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="531"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV63297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="560" mass="63494" checksum="238127FE11D28F8F" modified="2011-11-16" version="1">MASRIFGVTPPISTDNPSPKEITLNDQLIAELKARGSFESEQATRKRVEILNLFQKLVQEFVHKVSKSKNMSEGMAKDAGGKIFTFGSYRLGVYGPGSDIDTLVVVPKHVTREDFFSVFESIVRERPELEEITSVPDAFVPIIKIEFDGISIDLICATLNVPQVPLNMTLDDKNLLRNLDERDMRALNGTRVTDEILQLVPKPTVFKHALRCIKMWAQARAVYGNVFGFPGGVAWAMMVARICQLYPNAVGAVIVDKFFNIYTKWNWPQPVLLKPIEDGPLQVKVWNPRLYTNDRNHRMPIITPAYPSMCATHNITSSTQKVILSELVKGVDIVGDIKLGKRTWSDLFQRHDFFFRYKFYLCIVVGTKANEEEHSKWSGFVESKLRLLVQKLEATSGIEIAHPYVKDFNDSYDINDLEPFEVVNSYGILSGASVLNKLQKVEPRTIHGSEKEGDTPTKTLHLMKLFIGLDVSLNKSNDSTSKQPKKLDIQYPCSEFYNICKGWLGFQEGTHFIQIKNVKLYELPDDVFEEGEKRPIKQSKKRKADSKGDIQKRSKSAVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6B7</accession>
    <name>G3B6B7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114736</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6B7"/>
    <dbReference type="STRING" id="590646.G3B6B7"/>
    <dbReference type="GeneID" id="18247557"/>
    <dbReference type="KEGG" id="cten:18247557"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_0_1_1"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="242" mass="27287" checksum="8DEBBDF16951971B" modified="2011-11-16" version="1">MPRLELYSPEGLRVDGRRWNELRRFECKINTHPNSSDGSSYVEQGNSKIICMVQGPMEPKLRSQMDVNKANIEVSISIAHFSTFHRKKRSKNEKRIVELKTAIENTFENSIISHLYPRTFIQINIQVLAQDGGLLAGMANAATLALIDAGIAMYDYVSCVSAGLYDQYPLLDLNTLEENDMSYLTIGVIGKSEKLALLMLENKMPLDKLEPVLGLAIAGGHRVRELMDEEVRSHGKHRSQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6H3</accession>
    <name>G3B6H3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_114781</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6H3"/>
    <dbReference type="STRING" id="590646.G3B6H3"/>
    <dbReference type="GeneID" id="18247574"/>
    <dbReference type="KEGG" id="cten:18247574"/>
    <dbReference type="eggNOG" id="KOG1338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017135_0_0_1"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="18"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="522" mass="60896" checksum="E8EDD3D394D583C0" modified="2011-11-16" version="1">MVEFGASTINYVKWLKQNGVHFCKDCRIKDLRHKNEGRGIIAAQDIEEHDTIFEIPRSVVLNLETCSLVKERPGVREGLESLNQWEALIIILLYELKVKKEHSRWTPYFGVLPILDEENYTFNQLMFWSDDELEYLKPSLIIQRIGKDIADGMYNKLFPRVIKQLKLVELNDTTLWEYHKIASLIMSYSFDLERLNRDGVVNDEEDEDEDEGNEEVGNEPSYKNSPVSSSDEEYPDSWRNDSFLKSMIPIADTLNADTTLHNASLEYLQDKLVIRAIKLIKKGEQVYNTYSDHPNSEILRRYGYVERQGSKHDFGEITLASIRDHFSQCSNPIMHEFFDEIMDLFYRIIQEESSEEEVVEFVLDSYDCFASSEVIIELTILLQCLTIIGSIHSLNSMETLTVDSKFQLVRRIHRKCISLIESRKLTKLFLANYKAILGNRMSEYPAIASEDFPGSFKFTRQNMANVVLKSEYTSLRNCLDVEKTFTIDDIKYQFIDDDKLIRNIVKRKFDLPIPNSPKRNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6M7</accession>
    <name>G3B6M7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_122573</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686765.1">
        <property type="nucleotide sequence ID" value="XM_006686702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6M7"/>
    <dbReference type="GeneID" id="18248908"/>
    <dbReference type="KEGG" id="cten:18248908"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF15">
        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="63727" checksum="5FC4D0F0CACD8CD3" modified="2011-11-16" version="1">MTLPWFIPQLRNVEFEDDDDNSVINVIEKSKIGIDISDTKSDISEESTIAIKEYRDEANRPWWKFFDEFEYRYTTTESKKHDWWRWFEKGTSKEEKKLILKLDASLALYAFIGYWIKYVDSANLNNAYVSGLQEGIGMKGNDLINTQVLFTVGQIIFELPWIFLLPRVSLPYALFVCELVWATFTLVTYRAENPATLKAFRFIIGAAEACYFPIIHYSLASFYTATEIGRRGALFYCGQFLGVLTSGLLQAAASKIPNPGDSLSGWQWMFIIDGIISFAVAFLALIMHPGTPLRCYSIWLTDDEIKLARSRMKKNGSDVSPTVKSFFDKGTWKAILSSWHFWLLSICNMFGFNTNSASSGSFSLWLKSLDRFSVARLNNLTTIPPGLGLIWILIVCVGADLTRKRFGFIILSFIMNFIANFILALWHVPETAKWAGYLLAYWSWSQSSVFNPLISDILRHDNNQRAIEWMAIYIIGLQSSAWINRLTFPTVESPRFKKGFSSCAAFSLCFVITVSIIYVFYKRDEKKNALKNGIYIYDSSKGESPPTLEEKLERDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7F5</accession>
    <name>G3B7F5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115724</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7F5"/>
    <dbReference type="HOGENOM" id="CLU_1964735_0_0_1"/>
    <dbReference type="OrthoDB" id="4026706at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="128" mass="14577" checksum="4861FD1D9C447D2B" modified="2011-11-16" version="1" fragment="single">MAYSLSTSSLSNLMKPQAHQRSYSQTSLKSPIRRDSSDRKTLVDQFYSISESQVIHKQELTTVPYTSIDREVKSDPELTNYLLNIDTIVKDLNHDKLDDAGEEELGDDEQGISSKLSRNQDKKLLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7L3</accession>
    <name>G3B7L3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115103</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7L3"/>
    <dbReference type="STRING" id="590646.G3B7L3"/>
    <dbReference type="GeneID" id="18247719"/>
    <dbReference type="KEGG" id="cten:18247719"/>
    <dbReference type="eggNOG" id="KOG0302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025272_1_1_1"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="424" mass="46997" checksum="845748AD9F20A1A9" modified="2011-11-16" version="1">MEEDEGQASSSIYLPHKSKPLGPDEVLEADPSVYEMLHNVNMPWPCLTIDILPDNLGSERRKYPASVYVTTATQAARAKDNELITMKLSGLAKTLVKDEDDEDDEADDEDDEHVDPVMDSETIPLKSTTNRVRVSPHAHETGEYLTALMSETGEVMIYDLKSQYKAFDTPGLTVPKASKRPIHTIRNHGNVEGYGLDWSPLINTGALLTGDCTGRIHVTSRTSTNWSTDKTPFFASDASIEDLQWSTGENTVFASAGCDGYVRIWDTRSKKHKPALSVAASTTDVNVISWSSKLSYLLASGHDDGSWGVWDLRNFGAEAPSPVAHYDFHKSAITSISFNPLDESIIAVSSEDNTVTLWDLAVEADDEEIATQRKETQELYDIPPQLLFVHWQRDVKDVRWHRQIPGCLVSTGGDGLNVWKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7R1</accession>
    <name>G3B7R1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_109322</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B7R1"/>
    <dbReference type="GeneID" id="18246101"/>
    <dbReference type="KEGG" id="cten:18246101"/>
    <dbReference type="eggNOG" id="KOG3625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001517_2_0_1"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000242">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="18">
        <location>
            <begin position="51"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="19">
        <location>
            <begin position="142"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="20">
        <location>
            <begin position="718"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="17">
        <location>
            <begin position="1030"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV62299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1511" mass="171105" checksum="C1A29B6FFB93AB39" modified="2011-11-16" version="1">MNSKRILLRLSDDGEPISNTADNTGANTGVLILPSVPLPPNYTPGDVIFQLDLVMNAASRVSKNGTVYSNVTDGTVPFVRDSYRQFPIECSFHKDIRVSIPIYKSGVYNFYIGFEDPEGQPQSTKKFYFNVPPNLRIKDSFVAFNSINIQSVVSKWIGPLSDWDAFFGEVSYKGYNMIHFTPLQERGESNSPYSILDQLKFDPGLFESNAQAVKFIGDLMEKYSLMSLTDVVLNHTANNSPWLADHPDAGYNEVTAPHLRAAIELELKLFEYSDNLKKLGLPTEIKSGADLDAIMEGVQANVFVPLNLWQFFVFDKQKVLSDINDFYQNGEVEPVAIPGDVDINNLKQLSQYVLKICNKNASVVLEDRFSNQLDAAKFLGILSSLFDNKIGDIEFNTLENKASSIVDEINLDLYAAYDADVTTIKNSVKDRIRYLRLDSGGPQLGEITSDSALIENYFTKVTNPDGQVFHLANNGWIWGGNPLVDFASSDSKAYLRREVIVWSDCVKLRYGEGPEDSPYLWERMTKYTEQCARVFNGFRIDNCHSTPLHVGEALLDAARNVNPDLYVVAELFSGSEEMDKIFVEKLGLNSLIREAMQAWNVAELSRLVHKHGGRPLGSFTWLPLDEYAYPATEEPKDSKLPIPRVLTNVSPHALFMDCTHDNETPAQKRSVEDTLPNAALVAFCSSAIGSVFGYDEGYPELLDVVGEERQYKYVPDQGIRDVKKKLHHIRNLLAGESEDILQDHEMYIHHEGEYITIQRHNARTGKGWFLIARTKFGEGDSHQVLDPVRLVQTKVKLEFAHSLSKTGDYEKDSKYLTAIPTKLQSLEMPAIEYEGDTSIIKVTDDFIPGSIAVYSTYIPGVDIKLDEFVKTGGIASTIDLDLYDLNAILYRCEPEERDFSGGQEGTYSIPNYGNLVYSGFEGWISVLKKVIWQNELAHPISDHLRDGTWALDYVVNRLDKYATNSKGLGKFLDWLRSRVDAIRDVPYFLRPHFFALVVGTAYEACRFRSFRLLSSQIQGATNFVQSLALTSIQMVGKMNNTSLFPFEQIPCLAAGLPHFSNDYMRCWGRDVFISFRGLLIVAERHEDAKRHILGFAKTLKHGLIPNLLDAGRNPRYNARDAAWFFLQAIQDYIKEVPNGIEILDEKVSRRFPLDDTYVTYDDPVAFSYESTIREVIFEILQRHAKGIKYREANAGPNLDSQMKDIGFNVEINVDWSNGLIFGGQQFNCGTWMDKMGESTLAGNKGYPGTPRDGAAVEIQGLLKSALRFVNELGDKFSYDKVERADGSSITFKEWEDLVQSNFERCFFVPTSADDDQKYDIDPSIVNRRGIYKDLYRSGKPYEDYQLRPNFAIAMTVAPELFDAGRGYSAIKQADQIIRGPVGMRTLDPSDWNYRPDYYNSVDSTDFATAKGRNYHQGPEWVWCFGYFMRAYLKFTYKKVADEQVLFGDLNQKIQGHIKWIRESDWAGLTELTNKDGELCGDSSPSQAWSTSCLLDLYYDLWKRHYRVFDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7X2</accession>
    <name>G3B7X2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115135</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7X2"/>
    <dbReference type="HOGENOM" id="CLU_2483139_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="87" mass="10057" checksum="5AF6711FDC77E143" modified="2011-11-16" version="1">MEGTTQAKSLEIKEWCLVNRALVSICFQKETRFMSRLGRDMEHWEHCTVVLVSVSGPSRKCGFDYYRCVGLTTTCVWAYGVIPYVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B816</accession>
    <name>G3B816_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115794</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689030.1">
        <property type="nucleotide sequence ID" value="XM_006688967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B816"/>
    <dbReference type="STRING" id="590646.G3B816"/>
    <dbReference type="GeneID" id="90981709"/>
    <dbReference type="KEGG" id="cten:90981709"/>
    <dbReference type="eggNOG" id="KOG3246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063260_0_0_1"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="130"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="331" mass="38474" checksum="20D3627A25F5D7DC" modified="2011-11-16" version="1">MSVVLDEYKGFCIDYNCSTTKPEPIITTGIDCFVEHNASFKEQIEETEDIPVQLQNNKSNKKSKQEKKLQKQQKKQRVTERKLRREHPNGSELPTPNHSFNPILTTNKIKKIYSKLQTKEETKLFQYESVALYSTDLDQLLPGEWINDNVISLIYEYLNQTYLQKFQKFIKLISPAVVQLMIYTEYEIITKSDFEKGKFIFMPVNETEDGDHWFLVVVNILENSMLVYDSMEGDSGSENQNLLNILATKLFKTGIIASRKLNILRMKTDQQSNFDDCGVYVIMISCYLTHMLLNQPINFDLSNIKYNALKGRLDVLEIIDDLNTQINKPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8A9</accession>
    <name>G3B8A9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_94616</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8A9"/>
    <dbReference type="STRING" id="590646.G3B8A9"/>
    <dbReference type="GeneID" id="18250421"/>
    <dbReference type="KEGG" id="cten:18250421"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="221" mass="25055" checksum="E8E5B7C5269C443B" modified="2011-11-16" version="1">MSENITLYTAGSPNAKKVSIYLELLGLKYNIKTVDMGNNEQKSPEYLALNPNGKVPTLVDSSTDTTISESAAIMTYLSDKYDKDRKFSYEVGTKEYYKQLEIAYFQVGGIGPMEGEAMLYILFSSDDVPVAKERYRNETRRLYGVVEEYLKRNAANSPYFVGDHISIADVCVVTFLPILPRLGIEYDEFPLVRKWLKHMISIAEVVKGFNVPNPPPIWPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8B7</accession>
    <name>G3B8B7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_94621</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688807.1">
        <property type="nucleotide sequence ID" value="XM_006688744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8B7"/>
    <dbReference type="STRING" id="590646.G3B8B7"/>
    <dbReference type="GeneID" id="18250422"/>
    <dbReference type="KEGG" id="cten:18250422"/>
    <dbReference type="eggNOG" id="ENOG502QTCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008719_5_1_1"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF24">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="595" mass="68100" checksum="B377EF13B886C28C" modified="2011-11-16" version="1">MGITSASVTQRGKKNRCRTGCLNCRQRHKKCDEFKPRCGLCSKRGESCVWPTTKKEVTQDSFRFFKAARDATKETTLGLKKYSSRLQETLQTTSPTSPKSASSMSPRLQNLIDMVSHEVDKTTEKSPPKQDTSPASDSLSADLMAPFLNYSHLHRTFRDYMFTNVVNSKPEEPQEADFRNILQSPMPEFLNHSNSSKNLQDLLNDDDSLYMFSQQMPTHLEDEANALVKPVSLTDTDKISLYKTYLYQVAPWLDMFDTASKQFGTTVPLLAAKSDALLNSIYAIASRQTEQTTKDYPPEIAINLYENSLKLLIPTVNRTLDTSIITTCVILCVFEMMSSSPKKWRYHLEGCAALFKMHGINGFCDELERGLFWCYARMDVSSAVIGEQSTIIPSELWLPYNCSVYESKKVFNEFGNKEDMYANYMVYLCSRVLNLIANAKEDYEKDWEFLWGEISDWYEDRPFEFKPLVSFNSSPFPGILFVNGPAISANQMYHMAIILLIQNKPRLHKLVYSDHIKSPIWHAKQICAISLYNEHPGCWNNSLQPLWIAGQLLSSDQEHEVVLNLLSKIEATTGWQMNFRAEDLKKHWRQEAAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8K3</accession>
    <name>G3B8K3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dipeptidyl aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_124841</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8K3"/>
    <dbReference type="STRING" id="590646.G3B8K3"/>
    <dbReference type="MEROPS" id="S09.005"/>
    <dbReference type="GeneID" id="18249059"/>
    <dbReference type="KEGG" id="cten:18249059"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_0_1_1"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF160">
        <property type="entry name" value="DIPEPTIDYL AMINOPEPTIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="10">
        <location>
            <begin position="228"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="9">
        <location>
            <begin position="696"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="905" mass="103296" checksum="4681676BAB8FABB1" modified="2011-11-16" version="1">MTRNPPVEEYEMTDNLLSADISGSASVDTPTGPEAESDSDQDSVTSTIFDQLASTSDETDFHNDEVFQTVLQQYKGVTKSPKMCLIISGIGFLVWVVSLIVYANVSVSDITSKWKWQTTVQMSGFNVTLSPYSPQRKNLTMTSMRNGDVLPTFKYVRWLNRDQYPTSKSGAGYFMTRGPKGSYVLQNQKTAETDMFIENIQFAYENNFFYVEDVILNPARPINDPSAYHVLVTDSVRQWRHSSFALYWLYRPATDEYIPIQPANLVQSRSLIKLHFVEFSPDGQKVLFGVNHDLYVYTLETKEITTITNDGSPDIFNGKPDWVYEEEILSSDRSVWWSPDSENIVYSCINNTGVFEYEIDYYVKDANDIGMTYSLESEHKLNGVSQYPIKKNYKYPKPGTTNPVLGLKNFNFKSQKHTILKPRSQWSDFILYDASWIDNDHFLVKISDRTSSIQSKQVLTISTNKFKEIDEVDAAIGFGGWYDKYSTIVPVNGGYLDKIVHKNRTHLAFYETPLARAPRMLTSSSTWDVLDSAPVVYNANEQQVYTLANIKGSMDVHLIGVTLDSKVEFVLGNDKEGKYSFTSDRDGQYILLEYGGPEIPYQKIISTGDLNVHDNMNDYLSEVKMVSFYDDTKKAVDSYNLPTKVFRTIQVNHVPINVLEILPPNFNPKRKYPLLVNAYGGPGSQSVTKNYEVGFEEVVSCQLDAIVLKIDPRGTDGYGWETKTYGLKHIGHWEPKDIITLTSEYIHKNKLAIDKEAVAIWGWSYGGFTTLKTLETDKGKTFKYGMAVAPVTNFLFYNSFYTERYMKSPKDNQNYLTESLISDYSAFKSLNRFLIMHGTADDNVHIQNSLWLLDKFNSNGTENYDVHFFTDNDHGISFHNSDVIVYDKLFHWVQDAFSGKFIDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8T6</accession>
    <name>G3B8T6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_126397</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8T6"/>
    <dbReference type="STRING" id="590646.G3B8T6"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731909_0_0_1"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="4">
        <location>
            <begin position="21"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="357" mass="39743" checksum="B5B36C0DE2FF32E7" modified="2011-11-16" version="1">MSHSPPQNCSRILYTVEVAQASGVTNDFYSNIVSWSKTAKQVAVGVNKTCSIWKLNKNCKTPISFECPDVITCVSCSYEDLVVIGTEAGKIYVISQSDGRLRATYILDNIPIHTCTWFKNNKRFLVGDSSGNVYMIKTIHKQGILILKKDFTFKFHQQLVCGIVLNSDETQVAFGCGDCTVTVWKLEKYRFPVIKFILPHTSAVKAMGFCPWAPSLLATGGGYSDRTIRFWHTNTGTLLNSYFTNSQITSLNWCHSRRELVATFGPGHGGSILEVYKFPSMKPVKRNLLEPLFIRVSGASASPDGRYLCVMCSDSTIRTYKIWGNGSNQMVHNGFDVFESSLISLAEGLNHPSPVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B993</accession>
    <name>G3B993_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_125063</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688011.1">
        <property type="nucleotide sequence ID" value="XM_006687948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B993"/>
    <dbReference type="STRING" id="590646.G3B993"/>
    <dbReference type="GeneID" id="18249074"/>
    <dbReference type="KEGG" id="cten:18249074"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_0_1_1"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="220" mass="24490" checksum="80E7A392E6D8A9BF" modified="2011-11-16" version="1">MGLSRRQLRLLMVSGFSLFLMYIMYSSKGDNPSSLSDSRESANSIISANPNAKIDEAINNKISKLYQQEQAEKAAEEKAAVDAAAGIKVTEEIDAIEEDFDPVKELMQIRALAPMIVFSKSYCPYSKRLKKLLTEHYEITPSFFPVELDKHKHGKLLQEHLAKISGRATVPNVLIGTSNESKGGCDDFLNLHESGKLATMLNEWGNKKLSVKRLETPSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B995</accession>
    <name>G3B995_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_125064</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B995"/>
    <dbReference type="STRING" id="590646.G3B995"/>
    <dbReference type="GeneID" id="18249075"/>
    <dbReference type="KEGG" id="cten:18249075"/>
    <dbReference type="eggNOG" id="KOG1728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_2_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="155" mass="17711" checksum="CBAA8702DCC8495F" modified="2011-11-16" version="1">MATELTVQNQDAFQKQPHIFTNPKAKANKKTKRWFKDVGLGFKTPKTAIEGTYIDKKCPFVGDVSIRGKILSGTVVSTKMHRTIIIRRDYLHYVPKYNRYEKRHKNLAAHVSPAFRVQEGDTVVVGQCRPISKTVRFNVLRISASVAKSKQFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9C1</accession>
    <name>G3B9C1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_107683</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9C1"/>
    <dbReference type="STRING" id="590646.G3B9C1"/>
    <dbReference type="GeneID" id="18245975"/>
    <dbReference type="KEGG" id="cten:18245975"/>
    <dbReference type="eggNOG" id="KOG1438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_1"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="10">
        <location>
            <begin position="87"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="367" mass="39196" checksum="2F17A8E83C5B1D6A" modified="2011-11-16" version="1">MNEDSSVLTPYIKKLIEHPPTLTPEDLSKVLHLVFEGQASEIQIAAFLTALRGKGLDHESEYIAAATNTVMKFSHPIAAKDVPVDGYVDVVGTGGDGQNTFNVSTASSIVAAGMGIPVCKHGGKASTSSSGSGDLLKSLGVDLLKANKHTAVKVLSDSKYTFLFAPAFHEVMAKVASVRKKLGVPTIFNILGPLMNPAPLSSRILGVYKKPLGEQYAKSVLQLTANDPVHKKSMVVYGHIGLDEISPVGITSCWIVENGQITYKEISPKDFDLPEAALDLVKSGTPEENAVVLMHILKQDSPEFKVHSDNKDNHPVLNYILMNSAALAVVYGLTDSYVEGVKLAKNSITSGTALGALESFKDTLNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9U4</accession>
    <name>G3B9U4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_135903</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9U4"/>
    <dbReference type="STRING" id="590646.G3B9U4"/>
    <dbReference type="eggNOG" id="KOG0243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_33_3_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000019">
        <property type="entry name" value="Kinesin-like protein KIN-5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="3"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="734"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="394"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="785" mass="88922" checksum="AF2D97498A9F4F31" modified="2011-11-16" version="1">MSNIQVVVRCRERNQREVKAKSQVVVELASEQYSISQPTITINPCQNSQISQKILNSLDSKTYTFDQVYGPLADQELVFKKAVNPIFKEFLNGFNVSILAYGQTGTGKTYTMCGKTEIHNKTPIEIDKHSGIIPRVLCELFSHLNSNNDDYFIKCSFIELYNENLRDLLNDDVDDSNFGTNPGASSNNKKGLKIFENRNGNSGIYIQNLTEVNINSLNSGFRLLNKGINKRKVASTKLNDFSSRSHTVFTINLYKKDPNDSETIKHSKINLVDLAGSENVSKSGSINQRAKEAGSINQSLLTLGRVITSLSEKSLHGNDVNLNHIPYRESKLTRLLQDSIGGKTKTLLISTISPAKINLEETLSTLDYSLKVKNIENKPQLGQDFDLIMKQILIKDLSNEIIKLNKDLISTRSRNGIYMDENNYNSLLEENASNKNELTELKSKARILSSKVQKLEDEIKFKEIEEASLKHSDSEDCLNLIRSITNSLALMKANFNNNFNQISEDIDESLKSLPNILNDLMKNLSNDELFNKFKNNQNELNNKLKNLNDQFQNHLVSYYNDLDVSGMIEQFFKESVENQVKELQQSFMLDLNKVFNSQHSSLNSLYKDSFNKFTNTLISGSFNNVQQESKNWNSHSNEVYKKITSNMSDYQSNIKNSHIFNQDRLLNASTNVKNSLTNCINPTLDAFTKGFTNDVNKLMNETPKIHNMVNSSIGHLTSNNDKFQQIDNLLGSDNKISPLKANDQKLNRSPSKTPNKHMSAASKIPTLKDKENGEVIHNLKKRKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA18</accession>
    <name>G3BA18_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_107566</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in rRNA-processing and ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 90S pre-ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA18"/>
    <dbReference type="STRING" id="590646.G3BA18"/>
    <dbReference type="GeneID" id="18245963"/>
    <dbReference type="KEGG" id="cten:18245963"/>
    <dbReference type="eggNOG" id="KOG2321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009923_0_0_1"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000537">
        <property type="entry name" value="Ribosome biogenesis protein ENP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="13">
        <location>
            <begin position="372"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="12">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="522"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="613"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV61990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="693" mass="79530" checksum="98480A5BACEEA6A3" modified="2011-11-16" version="1">MVLKSTAVGGVSVYQVAGTNVSRSLPDWIAKKRKRQLKHDSEYQSRIELIQDFEFSESSNKIKVSPDGQYAMATGTYKPQIHVYDFSNLSLKFERHTDAENVDFIILSDDWTKSVHLQNDRSIQFQTKGGVHYKTRIPKFGRCMSYNPFICDLLVGGAGNELYRLNLDQGRFLNPFVVESDLGINALDVNKTHGLISAGLEDGTVEFWDPRARQRAAKLYVSDQLEESCEISALSFRNDGLSFACGTSEGKSLIYDLRASTPTIVKDQGYGFEIKKIIWIDENSSDTNKILTSDKRIAKIWDRNSGKPFASMEPSVDINDVEYIKDSGMFFMANEGISMHSYYIPNLGPAPKWCSFLENVTEEMEERPSNSIYSNYRFITRDDVTRLNVAHLVGTNVMRSYMHGFFIDNELYERVNLIANPNSYRDQREREIRNKIEKERESRIRTTGAITNTKVKVNKELASKLEGRTGSQAAEDIVNDDRFKELFENPDFQVDEQSHEYKQLNPVSAGVKDITVDNPRGLTAAEESDEDRIHDNEHGDDSESESSESEEDKEDEETTKQRQEKVKKEMERLRRKQDAKKQEEKFLNEMKVVSNEGPQQKVADSFASQVNQINKVSKQKRTDQEGTRLQRHARGEVEFTFNPGNKKSDRRVKFNREKSDDDIDEETKAQLKGRTKQRYSGRRSASRNQFRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA69</accession>
    <name>G3BA69_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114836</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA69"/>
    <dbReference type="HOGENOM" id="CLU_3014005_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="56" mass="6106" checksum="BFFCB902E8FC6F36" modified="2011-11-16" version="1">MRTSKSSNINAIEAQLLTHEKSTISGNNPTRTSSSFLDKGKKIQLPTLPASHFSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAA6</accession>
    <name>G3BAA6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_124012</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687564.1">
        <property type="nucleotide sequence ID" value="XM_006687501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAA6"/>
    <dbReference type="STRING" id="590646.G3BAA6"/>
    <dbReference type="GeneID" id="18248996"/>
    <dbReference type="KEGG" id="cten:18248996"/>
    <dbReference type="eggNOG" id="KOG2889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039466_2_1_1"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="205" mass="23597" checksum="3214B38E130ECF12" modified="2011-11-16" version="1">MQPAYNDKRRVSGYAHILETIVRNRIKDSLFYKQHLYLTNEQTILQVIVDNVKYVGGLDSSNRPSPFLCCLLRLLEIGPSAAVVGLYLKQPEFKYLTILTLIYIRLTQPPTEVYQVLDTYRSNYTKVRVLLSSPEMVDGVPVNYGIIHIDEFVDELERSDRVVGVVMPRLESRRRLVARGMIPDRVYHVQTLDEPESSDFSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAC8</accession>
    <name>G3BAC8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_108761</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAC8"/>
    <dbReference type="STRING" id="590646.G3BAC8"/>
    <dbReference type="eggNOG" id="KOG4592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012622_2_0_1"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="7">
        <location>
            <begin position="3"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="7">
        <location>
            <begin position="191"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="460" mass="52252" checksum="2E0BA1F64E079ABC" modified="2011-11-16" version="1">MRYSGIMNPKDKDFVTRFQLSQIVTEDPYNEDFYAQVFKVIHPNPNQVSQEQEQQNNSIAQAYLDQSGHRLGGRHKRADVALQRMQQQVQRAVTVAKERPKLTQYAREGALGKISIGSGKKPRQQLELFSKAVQMEIEKQEEEAAVPVASNSNEVKSYTKKDIMSILENIITNLMTIESESRLSSGVDTTPLWESLRILEQPSPKVNDESEVNPFIQCLNHEKALKIVSRLFKFLSREQILTIATLIMSNLENLNVVKAGSYTKYEDNKIPPKTARLIETHSLTFTKAFMTAVQDFKFNEIIGLLVILIEHNNVSYISTTKVGLSIFTTLLSRAELIRGEGSISATDLSEWSSCYDELFTSLESRIASIFPPQQETEDINESYVWQFLATLALGGKLNHQRIIVDEVRDQIFSVMNRAKALDSSDVNNFYKKQNILNNLNMFLVVMGLVADENEIKELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAD2</accession>
    <name>G3BAD2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_109776</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BAD2"/>
    <dbReference type="GeneID" id="18246141"/>
    <dbReference type="KEGG" id="cten:18246141"/>
    <dbReference type="eggNOG" id="KOG1920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001477_0_1_1"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="436"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="834"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="957"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="1130"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1214"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1214"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1344" mass="152779" checksum="6664062E2B5F6E8F" modified="2011-11-16" version="1">MRNLVILNKGNIVPSSQYYPETGPENVSYKAVFDVVSDSITFALTLINEGIIEIQQYLKTGDVNLLANFPISDPNSSLISFTHFVEMSQLILIYDNGDIISITYDLSNLDPDSSIIEIVGSIDVGLKTASWSPDEETLSLLTQENNLILLSRSFEPIVEKMLNPNDIKISKAKHVSVGWGKAETQFRGKGARALEREKEALKHAGLDLKDDSSQFRDPTVAQIQQGTISEFDNSSCKISWRGDCEFFSVITKEEVIIEDTDEMYARRVIRVFNRDGELDSVSEAIDGLEHNLAWKPQGSLIASTARHITEEGNAQLDVIFYERNGLRRGEFNTRLDSSFESISDIQWSSDSELLAFQLYDRVQLWTTKNYHWYLKQEIFVNQTNEFNTVSFIQFHPEKPLHLMIGTSMEGVSIVDLAYKVSSGPTILGDDIGISLVTDGSQIKLTPFGIANVPPPASFRELDIGSFNINDSAISKNNEYYALSTSSGDVILSYMRVNSLKSKHPKVVSTISRSEFLGPDEFIKQVAFINNSLLGVLVDGVNYSKVIIYDVSNLKNAVFLDAFDFETKVVLIRARSDFNALILESITGSVSQIDESLTITDVVSFPQLCRDLEVVVNATGTLTAFGISANGKLFANDTQVAVGVTSIKVTESHLLFTTAQSKLCFIHLDSATDNYKYDIFNSEFENQLVDERIRQIERGSILVSIIPSTYSVVLQAPRGNLETINPRIMVLSGVRKFIQAKDYKQAFLACRVHRIDLDILYDYDPSLFLNNLESFVKQIEKVDYLDLFVSGLHEEDVTLTKYKDTLKESDNSELMNEFQALQVNGIENHRKVIENKDKNIYNKDSKVNKVCEAVLAVLQKPVYFDKYLQTILTAYACQKPPNLSDSLKLIGTFKSAEQIEQSVIHLCFLSDVNKLYNTALGLYDVKLSLVIAQQSQKDPKEYLPFLQNLHIQPSKRKEFLIDDHLKNYEKALDWLYQLGDKSKSEFDDYVIEHTLYKKALYIYNYENNKERYNETLHMFAQHLRNEKNYAEAGFSFESLGELEEALECYIFSKNWKEALSIATNPSFAEDKLVESCESLSDGLVQDHRYSEAGFIQYNFLNNVNEAMRLYCKHYNYDMAILLAVKEKQPELVESIVDSQLNEGFGSVAELLADFKGQLNSQLRRLRELRAKKAEDPYGFYGIPNEDLDVPDNVSIAPSETSTAPSFFTRYTGKTAGTAKTGASRRSSKNRKREERKKAKGRKGTIYEEEYLIRSVGRLIDRMEQTQPDAIKLIEALIRRNMKEKAYQLQKNWLELVEFLKQNCEEIYKMEERDRERIDDSGEIYLIPEIPVPKINDFPISHTLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAV3</accession>
    <name>G3BAV3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="10">ITPase</shortName>
            <shortName evidence="10">Inosine triphosphatase</shortName>
            <ecNumber evidence="10">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="10">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HAM1</name>
        <name evidence="12" type="ORF">CANTEDRAFT_114925</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="10"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688699.1">
        <property type="nucleotide sequence ID" value="XM_006688636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAV3"/>
    <dbReference type="STRING" id="590646.G3BAV3"/>
    <dbReference type="GeneID" id="18247636"/>
    <dbReference type="KEGG" id="cten:18247636"/>
    <dbReference type="eggNOG" id="KOG3222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_1_1"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000009">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="192" mass="21150" checksum="D11B4FB42ADF6CBD" modified="2011-11-16" version="1">MSTITFVTGNKNKLKEVVAILAGETDGKSNVGKFTIVNAALDLDEYQGTVEEVTARKAKTAAELINGPVMVEDTCLGYDAMKGLPGPYIKWFVNSVGLTGLVDMLYKFEDKGAKAICTFGYCEGPGKEVRLFQGVTEGKIVDSRGHTNFGWDSIFEPNGFNQTYAEMDKSVKNTISHRFKALDKLREFLLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAW5</accession>
    <name>G3BAW5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UNC-50-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_109401</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAW5"/>
    <dbReference type="GeneID" id="18246109"/>
    <dbReference type="KEGG" id="cten:18246109"/>
    <dbReference type="eggNOG" id="KOG3012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066239_1_2_1"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="322" mass="37001" checksum="D0B7D8CD2AFAC2E0" modified="2011-11-16" version="1">MSKRFNLPYTTQDLFPPDLSMPSFSQTRPDSISGSSMVSSLPFTPVPNSYSTSSTFANGTSSSNSTQSLHKMFKRFFKPKTLDFETAMWEIFQLIINPRKMYRSQYYYKQYQTSGKNNYARDDPSFLILLTLFLSISAVAWGLAYSPHALDILKLIVYMVVIDFFLTGIMISTISWLVSNKIFSNSWGVTSQNRYNVNYIEWSFCFDVHCNSFLIIWCLLYLVQFILLPIITIKKSFMSLLLANTLYFVSIGYYFVITFYGFNSLPFVNTQSINSNNQNDSPVRTMQLILVVGILPALAVTWFLSLCLKINVACIMIDLYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBC4</accession>
    <name>G3BBC4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_99222</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBC4"/>
    <dbReference type="STRING" id="590646.G3BBC4"/>
    <dbReference type="GeneID" id="18250837"/>
    <dbReference type="KEGG" id="cten:18250837"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="18">
        <location>
            <begin position="72"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV62152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="448" mass="49966" checksum="7AD651C6991140C1" modified="2011-11-16" version="1">MAMHPGGPSIIMKYAGKDASKLFNRLHPSNVIETFLDEAHVVGEIDMPPDSAISEEEIIAEKLRIENLKRLPKVNQIYNINDFEAVARAVLPPHAWAYYNGGSDDEVTMRENHYAFHKFFFLPKILVDVRNVDISTTMLGTKTSAPFYCSAAALAQLGHPDGELSISRGCGTEDVIQMISSTASYSFDEILDETKPGQSHWFQLYVKPDRKHSIEMLKKCAERNVKGIFVTVDTPMLGKREKDFKFRYGEDGPNDDDDPITSYDDPGLTWADIDAFKKVSDIPIAIKGVQRSEDVLLAVEHGVDAVVLSNHGGRQLDFSRAPVDVLAEVMPILRAKNLDKKIEIYIDGGIRRGTDVIKALCLGAKGVGLGRAFLYANSCYGEEGVKKAVQLLKHEIALNMKFMGVTKIEDLNSSMIEKRDSYGFHRDSIYDANYETMRPIGLKDIPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBK3</accession>
    <name>G3BBK3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_115024</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688733.1">
        <property type="nucleotide sequence ID" value="XM_006688670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBK3"/>
    <dbReference type="STRING" id="590646.G3BBK3"/>
    <dbReference type="GeneID" id="18247679"/>
    <dbReference type="KEGG" id="cten:18247679"/>
    <dbReference type="eggNOG" id="KOG0273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007609_1_1_1"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="327"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="523" mass="57374" checksum="30671EBA1DD285D1" modified="2011-11-16" version="1">MSLSSTELNYLVWRYLQESGNELAAYAFDKETSCSEFEKNKATEVFSKIEPGYLVNLVQKGILYSLTEADARDETTRPEILTFFGSLLKEEKFIELSKTLPTTNDADVEMRPAEANGGVKHEISDVFHTQRVSPTIQFDQSSFSKWHPSTNVLAYVKADSSLLISAISGDKIAESAFLKGPGLENVCDLTAVSWSPLGNLIATANLVGDLSLWSPDGRLRNIAKGAIPHEEGTKPEVILDIKWSPNGQYFLTGGSNGKICLWNGSTLKLIQTVTHSSKASSEGWSTCWLDDLRFTVSCKSNTIKVNLIDNSNDFTDANTVIKTIGELRGHEGPASALSFNNASKLLISYSNSDNLIKLWSSNSPASESTVLRDEHKILPVVLLSWFPQELNSDLISVSINGTIRTWSLDKESPTDSVNIFRDDSCYNFDDKEPLKNNGSIVYAAELSPDGKWLALGDDAGRVSIWDVSVSPRCKGIFDQHDFDGSILNAESGNGISFISWNQGSDNLSVSFHGAPSVIINWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBK9</accession>
    <name>G3BBK9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_124405</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BBK9"/>
    <dbReference type="eggNOG" id="KOG1240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001696_0_1_1"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1099"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1488" mass="168565" checksum="0012CF6F20A59B5D" modified="2011-11-16" version="1">MGARLSLLAPSAPTVAISSYVDIFDNIQYVELINNSRFLKTIKAIDLNTGDAIIIKILIKPSNNVNSFNINLQEYTELMVKEASLLDQFNCYLPTNKFIETDRAAYLIRQLVKTNLYDRLSIRPFLEPIEKNFIAFQMLKIIDNLHSNLHIRHGDLKLENFMVSSSNWIMLADFASYSKPVYIPEDNPNQFSFYFDTSDRRVCNLAPERFYNSGSESEKLQNFDENDHFTGKNQITEQMDLFSLGCIIGELYLDGEPLFTLSGLFRYIKKEYTPDLSGIPDAHVRDMILKLISFNPNQRQSAKQLLSEYQNLIFPQSFYSFLYDFIRRLNDNNEFKGNENDRHVTPSDNRIDYIHKNFDKISYNLKFDYSVDALTGSMGMNLNLPGMPKNYQIRKTSSFQDIGESQQSSLIILNFVFSLMNTLKQPASKIKACELITALSERVNDACKLDRSLPYLCKLIDEYIERFSFKGYDGMSLPGISMDENTKTESYSSKVVVAALDAIATILDSCSYISPLNVSMTSEYLLPKLVKLISSDNDVKESELVKIKLASCVPHLAEVANRFWMMAKTFKTKPLGSVHEGEQNGANQGNASVSKENLYLVFEEISSLLLTDPNPKVRAALVDNIKPLCRFFGVDKTNDIILPHLITYLNDPDIELKLHFLKSILFIGPYVGVLSFEQYLLPLLLQTLSDSEQLVVLEVIEIFVNFVSSRLINPASEFNALNIYKELLSNTVHFFLHPNEWIRQSVLQLVLSINANLSNADRFCFLYPQIKAYLTYDVTNINWDSLYPCLTKPLTKVMYQMLLNWASAGTEKSLFWKQESMTMTSPSKFTTFSKNLGKSVFVPSRSNGNSFSIPNRTSLAHSSIPLTHDDKQWLLKLKAVGLEEKDFWKPFMLRAYVLQVSRGMSLHIANSVGTFSDVNAVEIKPRNIFFEVSYKSEVVTSASNGLSSNVPQDSITKTPKTGRSGSNSLVLPNFSKVTASIQTIQENVFGELELNNDSHGHGNLQSNKYLTTSGDSNITHKVISSNDEKVIISNMKHSYQGLNPHILHYLQNVDFELSINSFSEFGDPVKINEPKSADWVPEGKCISLINTNSDPRSPDSLVCIAVNPSSEFFVTGSESGILKVWDSSKLEKNIMVKTPSLTAQFKSAIIKVCFMKNRNIFAVSTIDGRIRLFRVDVSRGKNKKILKYSKLVLIRKYDLHGEYATLILFNYDNIKTTMIVATSKSRILSFNVITMKREFELQNPLVHGVPTSVILDSRKGWLLTGTDKGLLCLWDIRFSVLVKSCKIISRSSSVGTQIKQLILLSPDFRIDSSCEYFAAIGGTSDPVITIWEIPTLECREILSPYEPNPTVQHYSIEEIKDSSNSVKDILNELPLDLEQARINDNLGYMKMYKHISGVYIVNSISSGRLIFWKLDELERSISNSGYTFTRTMLNQRMGFTNEKASKTLTKDHQNPVKNLDVINDIGFVSIPYEIVVTADRGGVLKIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBP9</accession>
    <name>G3BBP9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115669</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBP9"/>
    <dbReference type="STRING" id="590646.G3BBP9"/>
    <dbReference type="GeneID" id="18247959"/>
    <dbReference type="KEGG" id="cten:18247959"/>
    <dbReference type="eggNOG" id="KOG3458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081931_1_0_1"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="169" mass="19094" checksum="4D11CFF339FADB99" modified="2011-11-16" version="1">MLGEFNIARHEWENVDKNPLPADIPEVEEVGATSAPLLSAAYFIGARCKPYNDDFLLCKDANNGGTVECLKEGRRVTRCAVSVLSDLNKYCFDEFKLNYECLEQNNHNLGACRNSEKIFNKCVFANLKLTKQIPGVKEQIHLKENPIYTGTSNDKKISKEFLKSKESQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBT1</accession>
    <name>G3BBT1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_136164</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
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</entry>
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        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
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            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">DUF1000-domain-containing protein</fullName>
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        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Kuo A."/>
                <person name="Sato T.K."/>
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                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
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                <person name="Lindquist E.A."/>
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                <person name="Lapidus A."/>
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                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
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        <source>
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        </source>
    </reference>
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        <text evidence="1">Belongs to the PITHD1 family.</text>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="30"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="243" mass="27353" checksum="99BB7C39B6D54328" modified="2011-11-16" version="1">MSCEDQHLNSHHHGDDDGHHGDHGHDHSHVAPVPTNAAQSLLSKIDTPHVTALNLANPPEDLQKLFKKPQNKYELKPVVASDCDSQLIINIPFLNGSVKLFSLIIRTNGDKYCPKTIKLWKNDKNIDFDNASTKKPTFQIEHPHVGVMYNEDDGTMPESLDSDIEFVEHFLPRHIFTGVQSLTVFVEDIHNNDDEDETRLHYVELRGEFTELSRDPVITLYESAANPADHKNLTVSGSQANIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBW7</accession>
    <name>G3BBW7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_95564</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689313.1">
        <property type="nucleotide sequence ID" value="XM_006689250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBW7"/>
    <dbReference type="GeneID" id="18250516"/>
    <dbReference type="KEGG" id="cten:18250516"/>
    <dbReference type="eggNOG" id="ENOG502S81P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318556_0_0_1"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="764" mass="89761" checksum="3F3C9A937A53537B" modified="2011-11-16" version="1">MTSVRGKRQRRSYSCGPCKLLKIKCDLTLPCSSCQKFSREDKCQASPPQPPTESELRIIEERKQRMSRRKKSTSTSSPDNTTNNTTVGAADDFQSPVSDPDTSFIVTKVRLQHPNLSMSSKSQSPYQDSSYSDVSGLRDIQGYFEQRHVSFSLISDSWFTLKLYFRRSGEPIFGNLATELAKSFTIDQEDVNLLKFIYPNKEALCQLLMGHFKGFKEDLFYMMDYRLLVRTMLEISDKLHSTEYNTPLVINSIDARTLSLLLPVLASGLVTYPHIVINPRYKNSDILSSWILISKKLREHFKKTDSLLDITYLMVWYFEIDNYYHSEGMLNENHYEYNNLLSNLLFDRKYMEHIISTDLDFSTLGEERETEFRVILSYWLRVRVIELNVLYFQYKSSLLRSNHILKNSIVPDDKMLKFVYGFQGFQSDDIMTSIYCTARHYYNQFNSVTSHACIREVVSSYLKVYGNSHSVTGKEIDQYELSIKNNRPIKIDYETTSMYFKSQIFILSFVKWLTFLKIEQGYFPSLRFVSYLTSMSASLNHYIFLDNELHQQSQGTESLISVLPQFHSYYPLEYLMHACMVQQIFLLSLKVFVNREDNTDNIVDLKELYDKMYNKFMVFSNKFVKDFNSVNFRPRLYRAFINVFVDMNTVHDLIEFDSQLEIEEFFQLISKHIPDIRFYIDSYFGCKSTMINYLSKLWYLFSYIRKSKRSDVVKITSKINFTNELIMSYQDKFTGFEISVDKIEDYIHTVVDPVIGQNPRESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBY0</accession>
    <name>G3BBY0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_116124</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBY0"/>
    <dbReference type="eggNOG" id="ENOG502RPTF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024940_0_0_1"/>
    <dbReference type="OrthoDB" id="4083013at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="400"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="570" mass="65816" checksum="9CA18D07AED270CE" modified="2011-11-16" version="1">MKESHKPKHKRMSSPKTAANPSSVSASTKVSPEHPPPSTSGSGTLDSQFIDNITNIIFTQTSNSYFPLDISLSSVSDEVAQVLKKFNLPCQKQLSITNKSLSDKLVPRLVKLDPSLKLDYSKFISHPGNLFVKNLSKTKLNHSKMFKFFNSHSSYRSLGELNIFNQTSTNDDDVFAILRFDNYLDVEFLLTKKFTSNPFHVNPNFQLYLNKYISKKQRKLIHEEFDEFNNYNSLVLENLSGFFPPGFEFSLVNLQSFFDKFRIFGNIQMIYFPVNLINANSDFVPADFGFINFEVSENSNLNILKCVYYLNHLTYEEFNDFSESTIAQHDLTSDFDANGAGTTNGIHISISQHKHNHYLYQFCPTLLSLANGVLSVSYIDMAFHSAFLNNFARYSNYQETNIYVNNFPTLFANNDAQWERFWQRFGAIKSAKIIKPQFYAKEDQSVGKIGFVFFEDFKMALKAIIITNNKLVSIDNSSYLIKTSFALQKLHRDRRKKSGDSLDQQLEAPAPYYYEYPERDEDDRSYTYSMPGPMGQFHQPFHQPFFFPVAQSVPFYPYYNYPSYHVYNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCE3</accession>
    <name>G3BCE3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116880</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCE3"/>
    <dbReference type="STRING" id="590646.G3BCE3"/>
    <dbReference type="GeneID" id="18248484"/>
    <dbReference type="KEGG" id="cten:18248484"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1294232_0_0_1"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="213" mass="23492" checksum="FBDD8D97162923AB" modified="2011-11-16" version="1">MSKRPSEQDPDPEKKFKHDNVESVGNNGHVDDGNGDGDGDGDSGNGNESTSSSTSASTSSPHQSAPKQASQTDISLTASSALSALQATSPPVPTTLPPASKPEHGSDEWHRLRKESHKEVERRRRENINGGIRELAGLIPTSDTNKAQILQRAIEYIKRLKENETNNIEKWTLEKLLTEQAVSELDASNTKLKQELERAYREIEQLKRELSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCJ4</accession>
    <name>G3BCJ4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_110647</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCJ4"/>
    <dbReference type="STRING" id="590646.G3BCJ4"/>
    <dbReference type="GeneID" id="18246210"/>
    <dbReference type="KEGG" id="cten:18246210"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_57_1_1"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442896" description="ABC transporter domain-containing protein" evidence="13">
        <location>
            <begin position="19"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="806"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="976"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="380"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114671" checksum="6E40DDF386B15845" modified="2011-11-16" version="1">MKFASAVLHAFWAVCATATSIEIENVQQFQTSFDRIKRGAIVNDVFEISPSLKPLTKEPEDKCPPCFNCNLPNFECTQFSQCNSFTGFCECRDGYGGNDCSEPLCGSLSDGNENRPKRKDPVCACKPGWGGINCNMCEEDNVCDAFVPEGLKGTCYKSGIVVNKLHQMCDVTNKKIVAILDGKIPQATFSCNKTAGSCDFQFWIDQKESFYCDLDKCAFEYDLAKNTTHYNCEQMACKCLPETMLCGEAGSIDISDFLTETIKGPGDFTCDVGDKTCRFSEPSMNELISSVFGDPYITLHCKSGECIHKSEIPGYDLPDKGRLTWSNLLLIILVAVVCVSLVAGSLYNISQSALFKPSGGYEPVNGELNVLNENFTPTVLSFENISYKVRNGAQVLNGINGLVKPMECLAIMGGSGAGKTTLLDILAGKNKDGHIQGDIYVNGNRLSPHDFKKIVGFVDQEDHLIPTLTVYETVLNSALLRLPRSMTMRAKQTRVIEVLSELRILGIKDRVIGSDFQRGISGGEKRRVSIACEMVTSPSILFLDEPTSGLDAYNARNVIECLVKLSRDFERTIVFTIHQPRSNIVSLFDKLILLSEGDLIYSGDMIKCNDFFSKNGYTIPLGYNIADYLIDVTVDHKKLIKVNSTSTGSDLENLAGLESEEQDLHSRFLSTRTTSDLDTTSEWAHLALHRDEYNSYNKISGDDEEETVIQVQNKLPTLFKESVLQSELNDEILALKNSPLKFEVNAQYKKASFITQVSVLSSRTFKNLYRNPKLLLTHYILSLIMGGFCGYLYYDVKNDISGFQNRLGLFFFLLSLFGFSSLTGLHTFASERIIFIRERANNYYHPFSYYLTKLLCDVVPLRVLPPVILISIAYPLVGLTMEHNGFLKAIMVLVLFNVAISIEILIVGILIRDPGTSTMTGVLVLLFSILFAGLFINSEEIKSQIKIFEWISLFHYAYEALSINEVKDLILKEKKYGLSIEVPGAVILSTFGFNVSAFWDDIVYLVGWLSAFIVLGYIFLHYLAVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCJ6</accession>
    <name>G3BCJ6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_111981</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCJ6"/>
    <dbReference type="STRING" id="590646.G3BCJ6"/>
    <dbReference type="GeneID" id="18246335"/>
    <dbReference type="KEGG" id="cten:18246335"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_6_2_1"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="13">
        <location>
            <begin position="46"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="246"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="50128" checksum="4316C4A8C545734D" modified="2011-11-16" version="1">MSQQAPTIDFDKIRSSSDGSVSGMMSSAFEEVVVNNPYFAAGGGLMLLGTGLALTRQAVIRSSGLIYRQLLVDLEIPSKDKSYLWFLEWMSQYKHRSSRHLSVETNFVQHNNGAVTTKFSLVPGPGKHLIRYKGAFMLVNRERSGKLIDMTNGSPFETVRLTTLYRDRYLFSDLLTEAKTMALKIREGKTVIYTSWGPEWRPFGQPRSKRLMGSVILDEGLDKMIIEDVQDFLKSGEWYHNRGIPYRRGYLLYGPPGSGKTSFIQAVAGELDYNICILNLSEKNLTDDRLNHLMNHIPDRSILVLEDVDAAFNKREQSSEQGYTSGVTFSGLLNALDGVASAEECITFMTTNHPEKLDPALLRPGRVDLKVLIGNATEYQVRNMFLKFYENDEQNCDIFMKKFKELGLKDVSTAQLQGLFVYNKRDPTAATAMIETLKRPNDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCN0</accession>
    <name>G3BCN0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116901</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690050.1">
        <property type="nucleotide sequence ID" value="XM_006689987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCN0"/>
    <dbReference type="STRING" id="590646.G3BCN0"/>
    <dbReference type="GeneID" id="18248497"/>
    <dbReference type="KEGG" id="cten:18248497"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_3_0_1"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="188"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="372" mass="41334" checksum="386CC113A8DBE362" modified="2011-11-16" version="1">MLWIFYILPLVYCQQVFNFNTDLHDYYVNGQSMLEFHKNLVDIPSVKPSELAVAQYIEQFLSSNGLTVELHKAAENRYNVYAFAGDERNSKILLTSHIDTVPPFFPYSIDGSRIYGRGSCDAKASVATQVFTYLSMLQSGDVVPGDVSLLFVVGEETDGVGMKSVGHSYNASWEIGIFGEPTELKLGVGHKGILMCYVNVEGEASHSGYPELGISATEILLPVLNDFLTSDWPVDELLGPTTLNIAQISAGVAANVIPPFANASIFFRVSSDLEALDKKVRSKLDGIEHLSYDIPFESAPVYLDYEVPGFESIILAYATDIPNLYHHNLTRRYLYGPGTIHVAHSDHEYVESKDLVDAVDGYKKLIKYNLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCZ8</accession>
    <name>G3BCZ8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1766-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_137348</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCZ8"/>
    <dbReference type="eggNOG" id="ENOG502S4T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069853_0_0_1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13455">
        <property type="entry name" value="MUG113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="232" mass="26901" checksum="E86DEEB5D0744660" modified="2011-11-16" version="1">MSQCLGTTTKGVRCKIPAPHGYCHYHKHQISPGKQYPEPSPGFIYIYTLNKFFNKRENNWFKVRNLPNTPPKHKDKWISYELRKSPYVFLKVGMTTQSVKKRIKQWEDKCHHDIMLINPHTDKVVYTNKLSHLFKRLAVKDKQKTYSSLTDEGAFYCSGNLAQAEGEIHKRLWSKYGKGSVSCKGCSDNSTRTNELFVNGFNIHVEWFLIPKKEISVVYDTVDGICTTYSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD60</accession>
    <name>G3BD60_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UPF0005-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_95703</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689461.1">
        <property type="nucleotide sequence ID" value="XM_006689398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD60"/>
    <dbReference type="STRING" id="590646.G3BD60"/>
    <dbReference type="GeneID" id="18250531"/>
    <dbReference type="KEGG" id="cten:18250531"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="251" mass="28172" checksum="D92D587B58AFE388" modified="2011-11-16" version="1">MSYQPVENQPPPYGNPEPRVDGDNIPDDFKYSVNVASCELPIRQMFIRKVYALLSVQLVMTLVVGLIIKSNSAIQSWCLNNMWLFIVSVVGALGFGIGTHVMARSYPTNLILLSGFTLCESYGIGLTCSMVKSDVVLQAVMLTFVIFVGLTLFAFQTKYDFTSWQGALSMGLWFLIGWGFIMIFFPQSKMANLIYSGIGALVFCVYIIVDTQNIMKTCHLDDEIPATMMLYLDILNLFLFILRILDSRSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDF6</accession>
    <name>G3BDF6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_137418</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDF6"/>
    <dbReference type="eggNOG" id="ENOG502SQPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098504_0_0_1"/>
    <dbReference type="OrthoDB" id="4026289at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442852" description="PA14 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="32"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="247" mass="26207" checksum="3D518CD804422051" modified="2011-11-16" version="1" fragment="single">MSIWFTINVLVIVQFLCAVATADTIGGCRPPSVDKGLYAEYINTTLDEYPFSNQSEATAALSAIDNSEAGLSWGGVTSQNFNFATPADSAVYAELYGKTVNVGYFGLRLSGYFYATTTGDYTFDISNADDTASITLGAGVAMDCCGSGPLTGNLDENAYYIQGSGSTTATETVTLTAGVYYPIKIVYYQEGGPSSFTMSVTYPDDITHTSDIDWYSSTDNSTSCPYSVTTTVTWTGTDTETVTVTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDK7</accession>
    <name>G3BDK7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116376</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDK7"/>
    <dbReference type="HOGENOM" id="CLU_2512406_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="85" mass="9513" checksum="67C2F09494864D51" modified="2011-11-16" version="1" fragment="single">MVMYVYYCTDYVIEAVAIPVPILMPPELKRSTSVVQKADNNGFTILGLVTLRPTFIPVNYISKSPLFQREHVSSGTPVQIEPKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE13</accession>
    <name>G3BE13_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase ECO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Establishment of cohesion protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_99855</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE13"/>
    <dbReference type="STRING" id="590646.G3BE13"/>
    <dbReference type="GeneID" id="18250883"/>
    <dbReference type="KEGG" id="cten:18250883"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039183_2_1_1"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="13">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="14">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="261" mass="29346" checksum="8B5EE9FC7E5D51A8" modified="2011-11-16" version="1">MKFKKSTIKPKNPKAKVQGSLGFKSGESHLNQTKTCPECGMTFYKLVKKDQEIHQQYHKTFVNGVTWQWNIDPKKILGEYTIQTATGLKKKNAKVKVISVDKQSDSQIRRVDDTLKMVNLELNAPSGSDAWKTSKSSLVTPKAFIAVLDSHIIGICTTEAIEDPEKQSRWMILRTQTIVPKQCNRSAKLGVSRIWVAPLWRRYGIASRLLEIVLTNSVYGVKLTRSQVAFSQPSTNGGLLVQKFNGIVHKSGEMILPVYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEA2</accession>
    <name>G3BEA2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nonsense-mediated decay protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116559</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEA2"/>
    <dbReference type="STRING" id="590646.G3BEA2"/>
    <dbReference type="eggNOG" id="ENOG502S5VM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049919_0_0_1"/>
    <dbReference type="OrthoDB" id="5361617at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45930" checksum="90E04C979F4F0905" modified="2011-11-16" version="1">MSALNNDDPGSLHHVDELVGPTTQSLHSKDDPQPTTKRINLILDPSAFTKGIGNIKRWYKDEYIQSRSEHIKDTKVILNLYIPSYTLHEFDYLQRGTSMTAFFARKSIRFIDELYENNQTSQDITPKFQVNLSIEAPFERGPRWKDCQEYQVIRPKVKDFPNFKTKFDSSLARRKAEDFGDLTNDINTKLSTSASSKVNDIQYENSESFSQAAATSEDYAQIPAKLRYLVSSCIFKKFIQPNDFTNVMEEWKVVSEDAITQVWMRSFGVDAMNVNEAELLIFKSYDVNRLFNPHKDFTLEDNVKPNSIFQEIIDTSEYRNKELGDPFRGHRSFRKRSTKKDQPNQIEKPISVDACEDPVTQQSFDYISYAPRKVEGELWKAPNDTSSRSRSRSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEK1</accession>
    <name>G3BEK1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116643</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEK1"/>
    <dbReference type="HOGENOM" id="CLU_2721985_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="72" mass="7521" checksum="69B23314658E3485" modified="2011-11-16" version="1">MPVHASNGPGENANIEVSTPKPQFKSKISLGASVVAHRLLAPPSMHRGHTPPRSRSKRALAKTEAGLGGLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEM2</accession>
    <name>G3BEM2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_115959</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEM2"/>
    <dbReference type="STRING" id="590646.G3BEM2"/>
    <dbReference type="GeneID" id="18248098"/>
    <dbReference type="KEGG" id="cten:18248098"/>
    <dbReference type="eggNOG" id="ENOG502RZ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_1_0_1"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000051">
        <property type="entry name" value="Glutathione-independent glyoxalase HSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="25"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="235" mass="25031" checksum="10645711D67FA189" modified="2011-11-16" version="1">MPSVLIALPSYHGPFFNDGTTTGTFAVEVIHPFEAFKAKGYDIDFASRTGSFGYDDHSLTEDFLKGDDKAILEDPNSEYNITLKKIKKASDVNPKDYDIFFAVGGYGASFDFPTATDVVKVAEDIYANGGVVAAVCHGPAIFTNMKDPSTGKPLIAGKNVTGFTDEGEKLFDTDKPLVKYNLDTMEGVAKKTGANFKLPGAPFDDFTVTDGRVVTGVNPASAGSTARAAIIASQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFC6</accession>
    <name>G3BFC6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Golgi apyrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_126815</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFC6"/>
    <dbReference type="STRING" id="590646.G3BFC6"/>
    <dbReference type="eggNOG" id="KOG1386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010246_3_3_1"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="185"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="73949" checksum="C5149FA07F99A0AD" modified="2011-11-16" version="1">MEIPDSKYKYGIVVDSGSSGSRLQVYRWPDPKYVAKNTKEPSILQSPPKITQEPNWSMKTTPGISTYSNKVKKIWPDHFKKLIKFAEEIVPKDKQSETPIFVLATAGMRLLTPKDQKKLLSQTCLELKKNSKFVIHNCGDHIQIIDGETEGIYGWVGLNYLMNQLENYDGKDAAHESIGFMDMGGASTQIAFVPSYAEDIKEHREDISRVTLRNVNGLTQEWNVFVETWLGFGANQARKRYLSQLVELSKINSNVGTSLNDPCLPKNAEISYDHDGTSYKISGIGDYEMCIRTIYPLLMKNVPCKEEPCLFNGVHAPRLNFDKDKFVGISEYWYTANDVFQSGGEYNYRIFNERVKKYCESNWADILENSGKGEYSKLDPDKFLKDACFKASWVINILHEGFDLPRLDLELPKEDVVEGEEKEITKVHVPFKSTDAIDGNELSWTLGKMLLYASSEIPSKEKDGSNIGVYPSEISGKKFVPAGGFIDGKGYDSDDDDNDKGFLLPLLVFLLLMFLVYNFAKGKVAFPKHRRFNQAKKLFFEMISKVPGLNNVLEAQLRYNELNRNDMDITLEEGALGSSQSSPNLTQLRTRSAINLSEGDNFAEGTINPQTNFLNKPFAMPKKSPFFQSQNNSRESLQRSVSNMSVQKSRNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFF2</accession>
    <name>G3BFF2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_110712</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFF2"/>
    <dbReference type="STRING" id="590646.G3BFF2"/>
    <dbReference type="GeneID" id="18246215"/>
    <dbReference type="KEGG" id="cten:18246215"/>
    <dbReference type="eggNOG" id="KOG0477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_0_1_1"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="481"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV60675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="853" mass="96092" checksum="6E11545A879A6E29" modified="2011-11-16" version="1">MSSPTRNPRKRQVDEDDEVLSDHSSPIPSSPPLPSSPSRPFEDEEEEIHDDIQDLNPSDEEDGEDLMENIEGDYRINEAQDQYDLGDGNIDDEEYEELDAATRRRIDNQLNRRDELMSRGGRSRSQAFLDGDDDGDDEGRLDQYGLPIQRRRRRQLEEEGDGMDELEEIDPFNEELSLESLSDIKAPSITEWILQPAVSRSIARELRSFLLEYTDEKGRSVYGARIRSLGEVNSESLEVSYDHLAESKAILALFLATSPAEVLRIFDIVAMEATELHYPNYSQIHQEIHVRIINFPNLMSLRDLRESNLNNLIKINGVVTRRTSVFPQLKYVKFDCLKCGAVLGPFIQESHTEVKISFCTNCQSKGPLKINSEKTLYRNYQRITLQERPGSVPAGRLPRHREIILLSDLVDTAKPGEEVEVTGIYKNNYDGNLNVKSGFPVFATIIEANSINKKEISNQNMSLFSEEEEREFRKLSQERGIIDKIISSMAPSIYGHKDIKTAVACSLFSGVPKDINGKHSIRGDINVLLLGDPGTAKSQILKYVEKIANRAVFATGQGASAVGLTASVRRDPLTSEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISVSKAGIVTTLQARCSIVAAANPNGGKYNSTLTLSQNVDLTEPILSRFDILCVVRDIVNEESDERLASFVIDSHMRSHPNTELGDDFMGEDDEVMEIDTPSKSSRQRRLAEVNKQKEKEISPISQELLGKYIAYARAKVHPKLHQMDMDKVAKVYADLRRESLATESFPITVRHLESILRIAEAFAKMRLSDFVSQSDLNRAIKVSIDSFVGAQKVTVRKKLQRAFMKYTLPTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFT4</accession>
    <name>G3BFT4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_96170</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-glutaryl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-glutaryl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11875"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87828"/>
            <dbReference type="ChEBI" id="CHEBI:87829"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-malonyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-malonyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11878"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87831"/>
            <dbReference type="ChEBI" id="CHEBI:87833"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-succinyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-71 and Arg-74) that bind to malonylated and succinylated substrates and define the specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689940.1">
        <property type="nucleotide sequence ID" value="XM_006689877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFT4"/>
    <dbReference type="STRING" id="590646.G3BFT4"/>
    <dbReference type="GeneID" id="18250586"/>
    <dbReference type="KEGG" id="cten:18250586"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_1"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061697">
        <property type="term" value="F:protein-glutaryllysine deglutarylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="242"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="307" mass="33719" checksum="36A39A743BA70A3E" modified="2011-11-16" version="1">MSTRLNKSMMEFQDHLRHSKRIVALVGAGLSASSGLPTFRGSQGLWKNFNMIDLATPDAFYIDPGLVWQFYSYRRHAALKAHPNSGHLALARLSQVPSVEFVTITQNVDGLSIRAGTPRHKLHEIHGSLFDLRCTSFGCNYVDHDNFVDPLTPALGGTEEEFDRSGRKRSMHGDEDTDGASVSPEFTPVKQLDDSELPRCPACGDLLRPGVVWFGESLSLQLLNRIDGFIEQGPIDLMLVVGTSGTVYPANGYVDRVRYKGGKVAIFNTDIEDSVVDGQQEGVWGFRGDAAETLPQALDPLISQVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFW2</accession>
    <name>G3BFW2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_132437</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFW2"/>
    <dbReference type="STRING" id="590646.G3BFW2"/>
    <dbReference type="GeneID" id="18249622"/>
    <dbReference type="KEGG" id="cten:18249622"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_4_1_1"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="334"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="477" mass="54289" checksum="CDC8D907078B3979" modified="2011-11-16" version="1">MELVHMRMYRLVDGKNLPIVESHVIYSNSGSFQLTAVSTRTMINRTIGTMEGQKHSNIDTHTGEVQPTATDVTLNPTSEAFLKEYKIRSSLERLIFHYAQRPLSKFSIQGLIEQSESLSPNFILQNAQNTVEYLLAYNARRLREFRRLPYLVVLNPSVAESYNGYLNTMSSLITASLYPPATLEENHAFAEKVLDEFINIHSDTLPSLSRGFNEVLHLVSTDRIKQFLDEHLRERISMRLIAHQHIQLSKALKEGTYVKGGKYNGVIKELDIYSVIKKNAEVVNDICLMKYDQAVEIRVDNNLYSNTYWSRAEPDLKASKKSDKVLFPYIEYHLDYMLTELFKNSFRAHIENKVHEPVNVTVSVSHSPLYLEVRIRDRGKGIPPAVLKHMFDYSFSTYESQEGEAYKTLNQPPGLGGNTVAGMGYGLPLSKNYIEIFNDTIPKDLDVENDAGRVKGSLTIQSYHGWGTDVYLKTVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWC2</accession>
    <name>G3AWC2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_91670</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683767.1">
        <property type="nucleotide sequence ID" value="XM_006683704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWC2"/>
    <dbReference type="STRING" id="590646.G3AWC2"/>
    <dbReference type="GeneID" id="18250099"/>
    <dbReference type="KEGG" id="cten:18250099"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017832_0_0_1"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="831" mass="93788" checksum="3CA01287685BC274" modified="2011-11-16" version="1">MTMFPTSDWVYIIPPYLLHTSLGAKLHRQLALISSELANSNAMPTCSPHYEAVPESKPIPQYHFSADPTIHNIIRDKLIYKFQIIGILGTSPKPPSELSDEEVYELFETFEHKLLADETMAKTASDTASDGSHPGSNTRHKKLSIESDTFGEVSLSTGVPLKYQKYLSYSLRDLLLHTKLEQNGKLPSQTRFLKVDDTYFDYSLPSSWVSLIPSSSLNSINRRVSIDCTHGDGYAQVEVATLKDPQANLEAIPSTYFNFITNNPVTPSSGIFYYEVEIVQECTQATDMAPLLANSDTSLASKNASQFCVGFVKRFLHHGPRNPSSPPPATLGYDANLVDLETIKDELVFSQDKMIQKPLDLSIEALIDDKPGEMKASFALDLGDSNFYNSIKGSESAQRTTILSMNRRLSSLSRQSIAELDSGRIDTEVTFSTNKVRESKSEKILKSDVVGFGINYIDNSLFITLNGVLLRTISKQELMSSNPLNDNLFSSSNPKGDSVYPMIGFKLNDVSINDKTDIAPTKLTVRGNFGFKDFKFNINHWVNLYKRDNEKDLNLRLLQQSQTAASSSDPNDVFEGQLLNVHDNSALLNRLIKGYLYTEGYTETFNALASDLKELSDITATKNEPNNDSKVIERSHAQERHALKMCFLQNRFDSILEILNSKYERFFSDKAGQILIFDIKLYKLIHCLKIYVEKLLNLGSREFEFEYDTNLSSSELYTQALNLATSIQKEYANNEEQTDKIRSAVVLLLVKDIKGYNNLPHIHVVLEKYQDKTAELFELVNKRILKGLSFNQTSNLESIVTRVDRNVEELTLTHCDNKFSLINFERDQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWS1</accession>
    <name>G3AWS1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112318</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684100.1">
        <property type="nucleotide sequence ID" value="XM_006684037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWS1"/>
    <dbReference type="GeneID" id="18246467"/>
    <dbReference type="KEGG" id="cten:18246467"/>
    <dbReference type="HOGENOM" id="CLU_1461123_0_0_1"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="185" mass="20609" checksum="B9B6E9F6AA207366" modified="2011-11-16" version="1">MSLAISNSSTSLYNLSNCLSEESTLLEDYKLVQEYLSFVVDDYLEDPHPTMDPIQQDDIQLPARSPARLLNQKPIEIPDSPDLGLSDSSSIDYNSYGSDRSSRSSIFSDHQTELQPQPSPTDSPEGLSDEEMLVLYGYVDVEQEQVVNKVHDVITISYSHNGNDHQKSSQLKVVDVQVRAPGAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX19</accession>
    <name>G3AX19_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_117826</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683924.1">
        <property type="nucleotide sequence ID" value="XM_006683861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX19"/>
    <dbReference type="STRING" id="590646.G3AX19"/>
    <dbReference type="GeneID" id="18248599"/>
    <dbReference type="KEGG" id="cten:18248599"/>
    <dbReference type="eggNOG" id="ENOG502S75H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086812_4_0_1"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="152" mass="17551" checksum="422D110A814AB4B5" modified="2011-11-16" version="1">MALFDRFCFYYYLIHIPVTVLIDSSVVVTPVFRFQEWIIDFHVATNKDILMTSKPLWFKGFVWIELLFQLPWFVYAMVAQHSVTWHLLNVVYGVNASLTTFACILYVIGEGPLHGLSDTETWKLVGVYVPYVVLPLVILAGSFRRIRASTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX37</accession>
    <name>G3AX37_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_132937</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX37"/>
    <dbReference type="STRING" id="590646.G3AX37"/>
    <dbReference type="eggNOG" id="KOG1861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015513_0_0_1"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="172"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="386" mass="45163" checksum="2C043C55A63CCF0A" modified="2011-11-16" version="1">MKTSSEGTSETPDQRWPSSLEKFVSDSFVKSGALNPHEKLIFHQQIKELLEKAEAQNKVFSNNWEMQKLPIFHPGLPLDLCSNISFSSPESSVKRKKESQNKKRATLSPPELTPKMHDSEHKKPQNKKYDSDHKKRQRLERFSSPDLPSKPVLSTETTKNGAIVGRSQVIEKRYLRLTSEPDPNSVRPQAVLQQAVTRLLDLTNTKPYSYIKDQFKAIRQDLTVQHIKNDFSMYVYETNARLSIRNNDLGEMNQCVTQIEYLFDSKQERNSRLNRLELEFMCYRILYMLMVGNHSEIFKIKYKLLKKQYQHPEEVDMLRYAQLAFDLQNSMLTSNFYSFFQIAEKFKTMELGSILIQNYLIEKEKIKTLDILAKSYKKLSEDFAMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXA3</accession>
    <name>G3AXA3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic binding protein-like II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_112072</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683988.1">
        <property type="nucleotide sequence ID" value="XM_006683925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXA3"/>
    <dbReference type="GeneID" id="18246345"/>
    <dbReference type="KEGG" id="cten:18246345"/>
    <dbReference type="eggNOG" id="ENOG502QRHZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061316_1_0_1"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="87"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="307" mass="34306" checksum="BFF475A2D3194EFB" modified="2011-11-16" version="1">MPATLRVAYVPEHFSTPLFLAQEQGFYGNITIQFVPVIEGSGRLIKMLNTKEVDIAIGLTEAFISDIAKGNEEYKLIGTYVESPLCWAVSTGYDRSDITQLSDLQGKRIGVSRIGSGSYIMSFVLGLQEKFASPFFSDHPVLSNFKNLRDSVNLKFGSAGDGELSDSDAFMWEHFTSKKYYDTKEIKKIGEIYTPWPSWVVNCNSKLLEAEKPAIKQFLTGVRKGIEYFWAHQDEATTHIATHLDYSKADAEKWIETVKFNNSVGDEPINRKTVVDNTAKVLQTAGVLTDSDDVITQRLSQGVVFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXK8</accession>
    <name>G3AXK8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_117219</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683666.1">
        <property type="nucleotide sequence ID" value="XM_006683603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXK8"/>
    <dbReference type="STRING" id="590646.G3AXK8"/>
    <dbReference type="GeneID" id="18248555"/>
    <dbReference type="KEGG" id="cten:18248555"/>
    <dbReference type="eggNOG" id="KOG1991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004196_0_0_1"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF28">
        <property type="entry name" value="IMPORTIN BETA SMX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1000" mass="114745" checksum="FFE94071821923EF" modified="2011-11-16" version="1">MDRETLLKALAGTLDASNYQLRKESEQQLRFFEQQPGFTAYLLDLCMEPEVPQGVQISATVLFKNRISSYWVSSTERSETFSIKDDEKPIIKTKLIETLVKTIKNSRIRSQLALAIHSIVNAEKWDNLNEIIKTLLSSGEVDQINAGLICLYQYTRAYRWSHLESSNPILDDITTELFPTLEVLMDNLLANDSAVSDEMMYLVVKIFKFSTYSVLPTYIQDQNNLGKWCRFQIMLINKPLPDSVMQEEVLEERASIPRIKAVKWCFGNLHRLLSRHGGGFSTRNKEDNQFAKFFLSTFVPEILKVYWNIIENWSAKRIWLSEGSLYHMISFLEQLIENDAWSLISGEMEAILKHVILPPLQATDETVELYEDDPEEYVRRFFDINRESNTSDVASISFVYRLSSKKFAETSSLILGIISDIFDRRAKNRNDVSIAKEVEGALRVLATISYKLDKKQSPVHGQIDQLIYAYVYPELSEDSIAKAPYLTARACDTLAMFIYTYQDTSVLQQIFTGVINCFQKHDHLPIRLTAVDALRTLVDNDAVADHIAPQVPQLMGSLIEMTKTFESDTLTSVMESFVEKFASSLEPYANDLSARLTEQFLRTANELLEMQSGSNSGNVDIDKEYQASGILKTITTLVVAMSTSPSVASSLEHVLKDSVVFVIQNAQIAFLPEVLEILESLIFATQRMSPLMWELYQVCMDSFDTYAYEFFDNFSTYFESVIFYGFTSEDVTIENKQVQSLITVCFEVLRSEFVEPIFAHSAFELLELIILALNQRFKPFLVTFLPEIFQIFDNLKAQEAFDGYMLHQLSIARIFFATSYVDPITTLQFLNEKQFTPSFFKLWIEHSDDFQSVHGCKLQILSCIAFLCDGELSLIQDQDLIGEITDLLISNLEVLPHAIKTRQDIQSKEYGVRQFLNEDEDGEYTGEYLADDYDAEAELEAMKQTPIDNINVYESFVTKMQLLQQQKPQAYQEIVERFSDDQKIIVNRVFETFNKIRAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXL3</accession>
    <name>G3AXL3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_91956</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXL3"/>
    <dbReference type="STRING" id="590646.G3AXL3"/>
    <dbReference type="GeneID" id="18250136"/>
    <dbReference type="KEGG" id="cten:18250136"/>
    <dbReference type="eggNOG" id="KOG3228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068312_1_0_1"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="206" mass="23296" checksum="CBC231FC3A1AF335" modified="2011-11-16" version="1">MTTNHRPTLESKKGKKRPIGDSVVHARGLSQQTELKYRSDAPFYNVNGDEVKRFNGEVNAQTKRLKTERDEESSGSVNTKYESRDPDEVDDNTIKEDASVDDNDPATSNSEAFDDDSDSDSDSDSDEDSEALLAELANIKKEKEEQKKLQDQRLLDANPLLSTATKKSWRKSAFRSDKDNTTKDSKFTTNSVDSDYHQTFLSKFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXP3</accession>
    <name>G3AXP3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_91982</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXP3"/>
    <dbReference type="STRING" id="590646.G3AXP3"/>
    <dbReference type="GeneID" id="18250140"/>
    <dbReference type="KEGG" id="cten:18250140"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030821_0_0_1"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="266" mass="29278" checksum="5B94BB92A6102980" modified="2011-11-16" version="1">MVTTQSYTQRAEIHPSPVAQRLLRLMDSKKTNLCASVDVRTTSELLSLIDKLGPYICLVKTHIDIVDDFSYEGTIVPLLELSKKHNFMVFEDRKFADIGNTVRSQYVGGAYKIAQWSDITNAHGVTGAGVVQGLKQGAQETTQEPRGLLMLAELSSKGSLAFGEYTDKTVEIAKTDKEFVIGFIAQRDMGGREEGFDWLIMTPGVGLDDKGDGLGQQYRTVDEVVSTGTDIIIVGRGLFGKGRDPDVEGKRYRDAGWAAYQKRCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXP9</accession>
    <name>G3AXP9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_112537</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXP9"/>
    <dbReference type="STRING" id="590646.G3AXP9"/>
    <dbReference type="MEROPS" id="A01.067"/>
    <dbReference type="GeneID" id="18246567"/>
    <dbReference type="KEGG" id="cten:18246567"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442749" description="candidapepsin" evidence="17">
        <location>
            <begin position="22"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="18">
        <location>
            <begin position="99"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV65668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="585" mass="61708" checksum="A28BA291F0923BD4" modified="2011-11-16" version="1">MKLGPLTASILASWHVGMAAATQVETTVVPTEQPGFFALNFEIQRGNSKTDMGTERTPRLIRRMLSDEEQASSPLFERGRKVWRRDFFEMTLENADTFYLTELEIGSNGDKNQVLVDTGSSDLWVMAHDVDCHAESSSASTKKRDLGLHVGDIFVHPHEDSISPTKTEKLQGKANANSILSAFGITTDSPFGGSGGSGSGSGSAVAVAVATDSGSTTNTCTSYGSFNTANSESFTRNSSAPAFSIRYADGTSAEGIWGYDDVKISNATVNNLSFAVSNDTSSNIGVLGIGLAMLEVTYSSGTSNAYTYENLPARLASQNIIAKNAYSLYLGSSDSKTGTVLFGAVDHAKYSGTLQTVPIVNTLESYGYESPIRLEINVDEISLTNSDSVQVNSNGYTALLDSGSTLSYFPQSLLEKTASTLGLDYSNSVGAYLIDCDVSGDTSIDFTFSGINISCPISHFVVQVTSGTCAFGILAQSSSSDYLLLGDNFLRNAYVVYDLEDLTISLAQVNHSDEEDIEVISSNIPQASSVVSAATAANSGGSESTASGSVTLSNSDTDSSRDSGAIRMVPKLMTAAAFVGVILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYD3</accession>
    <name>G3AYD3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_118584</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYD3"/>
    <dbReference type="STRING" id="590646.G3AYD3"/>
    <dbReference type="GeneID" id="18248652"/>
    <dbReference type="KEGG" id="cten:18248652"/>
    <dbReference type="eggNOG" id="KOG2434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010579_2_0_1"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="76362" checksum="1106D81CDBB43686" modified="2011-11-16" version="1">MIMSIHDPLSRKRPLDNANEESPNNLDNHQGPMNKKVREDDFNDKMYTIFVKTALEKLEHNRDTNQIESLTTKISLPRDNSESITTANFKVVLKNLISNVSKLDNESCNQLILSIIDYKWINVQDSEFKDIYSQFLLVLISSIPKYLFKVLNKICSEFKDVDNHSNHLHHSIMKNIVKYNPTILNKFPSVFQRNFPHYLASDSQLLSNYILNLVKALEYCGELQYDVWLLVIECCIKLDVELQNDLDDLDDEEIDELINGVEESDKGGNGENNSDDDSDSDADSDDEKDPEIDSGSDSEDENMGDEEYLINPMTTTKDIRLLVNRLDSIIHLLLKSASESFNAEQLNDGNGVYLFNTLSSLFRSHILPTHFTKSIQFLLFHITQYQMELSDSFLVLLIDITFNPSQILETRLKSMQYLSSYIARAKCLSKNQIVFVVSYLVGWLNKYIEEREFEINLSNSNDKSVGGMERFKLFYSTFQGLLYIFCFRYKLLQVEIKGDFEWEGEIDKFFQRVIITKFNPLKFIDETVCFIFANIATKLNVCYCYSIIEHNKRERMLHTSTDTKDNNLSLPASIGNFKQKQEFLDLEGYFPFDPLVLPLSKKLITSNYIEWSEVNPNQDEEDEDSASGSNHHTSSEEEDFEEENNNDGSSSSSDDNDTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYF2</accession>
    <name>G3AYF2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112701</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYF2"/>
    <dbReference type="STRING" id="590646.G3AYF2"/>
    <dbReference type="GeneID" id="18246644"/>
    <dbReference type="KEGG" id="cten:18246644"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081897_0_0_1"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="303" mass="34586" checksum="26CF631C647FC335" modified="2011-11-16" version="1">MSDGLTTEFSMMSLALYVAYRALRNNETPVACIMVDKNIQKVLSVGYNGTNDTLNGTRHAEFIAIDSIFDQFIPKEKHGDAEYVRSFFSNVILYVTVEPCVMCASALKQIGIKRAVYGCGNDRFGGNGTVLKINDDEIDGRRGNYKSYGGVLRSEAVQLLRNFYIQENDTAPKPKIKSNKQISEKKYTPNIDFFNLYTSDEFNDFYTCCDPNLFHVDHEVFYEITPNGDSYSLNEYISENTVNMLPDLPQLFGGHSSFDVVEDIETFCSLFYDIKHQKVDFSKTIQTVEDLTKYEKKRKLDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYG8</accession>
    <name>G3AYG8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_112721</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 11"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYG8"/>
    <dbReference type="STRING" id="590646.G3AYG8"/>
    <dbReference type="GeneID" id="18246648"/>
    <dbReference type="KEGG" id="cten:18246648"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833525" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="451" mass="49571" checksum="FD1450B3C5A9E1FB" modified="2011-11-16" version="1">MRASYVRLYSAALVLLSTLIEGLYLDPDNFTSLQEATALISDGILDYYAGTTKGGTIGTFVWPYYWWEAGGVWGGMIDYTILMKNDTYTSLIKEAMTYQTGDDNNYIPLNQSTTEGNDDQGFWGLAAMGAAERNFSNPSDPSKAWLTLAQAVFNTMSARWDESSCGGGLRWQIFQWNSGYDYKNSVSNGCLFNIGARLARFTSNDSYIEWCERVWDWMYGAGFMTEGTWWLVYDGAEIDGNCTNMTKYVWSYNQGLMMSGAAYLYNYTEDPKWLERTENLLVGAKVFFDDDVMYERTCQGSNNCNQDQRSFKAYLSRFMGQTAVMAPSTYDVVMNYLTTSALAAARSCSGGSDGHTCGLDWTNTTGWDGTWGLGEQLCALEVITQLRVGDVDPPYTADNGGSSLGNPAAGYGTVVSDATPLTLGTKDKAGAGIITAVIGVSIVASTVWLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYS3</accession>
    <name>G3AYS3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112794</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYS3"/>
    <dbReference type="STRING" id="590646.G3AYS3"/>
    <dbReference type="GeneID" id="18246676"/>
    <dbReference type="KEGG" id="cten:18246676"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="667"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="698" mass="78596" checksum="B5ECB07AE584E7CB" modified="2011-11-16" version="1">MSSPFGVDFGNSNTVIACARNRGIDIIVNEVSNRTTPSLVGFGTKNRFIGESGKNQQGSNLKNTVENLKRILGLNYNDPDLEIEKKYFTSQLVENEDGGVSAKVRFMGEQTEFTSTQLAAMYLNKIKDITVKETKANIQDICLSVPIWYTEKQRRAATDACKIAGLNPVRIVNEVTAAAVGYGVFKANDLPEDEPKKVAFLDIGHSSFQVSIAAVKKGELKILGSAYDKHFGGRDFDLAIANHFAEEFLTKYKINIHENPKAFYRVLSSAEKLKKVLSANSSAPFNIESLMNDVDVSSSLTRDELEEFIQPLLERIHLPIEAALKDANLTTDDLDSIEVIGGCTRVPSIKARLTEIFGKQLSFTLNQDEAIARGNAFICAMHSPTLRVRPFKFEDFNPYTVSYYWDKEDDDDVDHMVVFEKGGLFPSTKIITLVRSGDFELEARYTNKEELPAGTEETICKWEIKGVNVSEGEKTIATKLKLRNDPSGFYTIESAHTFENKLVKELIEPSEEDSEDKEPEYREVKKSVKKDDLVIISHSSALTDAARNEVTEKENSMVMEDKLVAETEDRKNALEEYIYELRGKLEEQYKDFASEQEKEKLTGLLLKAEDWLYDDGYDSSKAKYIAKYEELASIGNVIRGRYLAKEEEKKQAVREKQEAAQAAFIAEKLAAQRNTQQTPNQTKEEEAPKEEQDIEMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYV0</accession>
    <name>G3AYV0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_101956</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684508.1">
        <property type="nucleotide sequence ID" value="XM_006684445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYV0"/>
    <dbReference type="STRING" id="590646.G3AYV0"/>
    <dbReference type="GeneID" id="18245518"/>
    <dbReference type="KEGG" id="cten:18245518"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_4_1_1"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="54"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="311" mass="35439" checksum="E0CCF2A4A18C02A1" modified="2011-11-16" version="1">MTPIAHQTAISSFNSNHTSYDQFRPDFDPISVDKFLQDLGLIENQSPKTDKVILELAAGTGKFTKNLVDHGWKDNLIIVEPSKGMLESFEKNFPGIKTHLNSSYDIPAEDASVDSVIVAQGFHWFADRDSLKEIKRVLKPSGTFGCIWNYDGPSPSQVDVGSKTHYLLDNSLSTKVHIPEGADSMDISNSTIGLHKWNVHLVDYIYSFDVDVPQYRTGVWKKVLMDNEYFKPIEVETYFYKISSIPKHSVFQYWLTRSFITKLSDEEKVKCEKTINEIIDKYVTDDDKIQENGNIYLQRVLGTHSIVAFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ55</accession>
    <name>G3AZ55_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112877</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684854.1">
        <property type="nucleotide sequence ID" value="XM_006684791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ55"/>
    <dbReference type="STRING" id="590646.G3AZ55"/>
    <dbReference type="GeneID" id="18246716"/>
    <dbReference type="KEGG" id="cten:18246716"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_2_1"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="226" mass="25817" checksum="DA24ED83F791E395" modified="2011-11-16" version="1">MTVSIEPNTDDKVLRIFFIRHGQTDHNLKKILQGHVDVDINATGEDQADKVGQMLKIVKFDHFVSSDLIRCIKTTKEIIKYQDLDDFRTTYNLREREMGKVQGMYIKDALAQYGDGFRNMGETSEKLLERVNKEFDTILKEAIIRGNKNVGVCTHGGVLIQFFNHLYKDKHYKMNTKLLPEDLRVPFNTSVSVIDLDKATGEGLIQAFGDTTHLGADLKVNNQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZB6</accession>
    <name>G3AZB6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_119188</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AZB6"/>
    <dbReference type="eggNOG" id="KOG1517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001136_0_2_1"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="84"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1262"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1376" mass="155820" checksum="DC9A417BEB0E417F" modified="2011-11-16" version="1">MPDSPLVYYGPRNLQPLNHAMRHGFEFEYNSETFLTSLANTFYIYFDDKRHNTNGNPVTPAIKASAEYAKHYQAIADWKIMKERQKTVSAMLMLCLNLGVDPPDIMKTYPCAKLESWCDPTAFSDTKKAIETIGKNLQSQYETLTLRTRYKQSLDPSVEDVKRFCNTLRRNAKDERILFHYNGHGVPQPTSSGEIWVFNRGYTQYIPISLYDLQTWLGAPVIFVYDCNSAGHIVHNFKKFVQKRIDDDNEGNHDISSPSPTSSYLDCIQLAACRSNELLPMTPDLPADLFTCCLTCPIDISIKWFIMQSPLRKSYYDQLPRNAVGNVVIPGKLTERRTPLGELNWIFTAITDTIAWTSLSRPIFKRLFRQDLMVAALFRNFLLAKRIMPLLNCNPISDPPLPETVRFHTMWESWDLAIDQVLSQLIRSQTIPQSVSSPVTTTMATTNSPINSTASPGQHSTFFEQQLTAFEIWLKFSAPSTKEPPEQLPIVLQVLLSQVHRLRALILLSKFLDLGPWAVYLSLSIGIFPYVLKLLQSPAQELKPVLIFIWARIMAIDYKSTQQELCKDKGYNYFYTILNGSPSASGSGPLINDDHKAMSAFILTLFIKDFKNGQRLCFSVELINNCLRYMALSENPLLRQWCCLLLSQLWRNYPDGKWIIYKDGYLSKMLSMASDPIPEVRTAIVLGMTAFLSDGSRQQNQPQSQGQQLQQQQHGAANDMRRDELRQQDLRLANIVLGLLGDGSAMVRKEIIFFINKFVANYHQFFLVVAFNQLEEEVVLIDNSNQLNDFRKKSPAYGSIFSSVWKALLILAEDPHLEVKQLAETLIDTVMLQLNESELGPLVRDMQMYLLSKSSINISASLVAKRQISSASMVSRKNNTLTINGARRVASASHADTSSVHSESSLAESLTNRLKGLSLAKLVSSLHINDDTELNNFTRILNSSPVSSNYHAEYRPKPPRFTPRDVSADVHLSEESGFFEYSCEYFQEPQMSKSELDEPGSQEYIERLWRRNRNEAIIQETQPQKQMAIRGDWGRSPVVLDNKTQPKLIKFTQFEKNLVVCDDKDNVTVWDWETGKVVNRLSNMNPAGTKITDIKFLNEDDSPLMLAGSSDGVIKIYKHFTSDRTKPELVASWRALTDLLLTAKSTGLICEWQQSRGSLLVTGDVKIIRVWDAPRELCLVDIPARSTSAITSITSDQVAGDIFVAGFDDGSLRVYDRRLDPRESMVRTWTGSSHPNQHQQQRSRVASPIRNIHMQRGGYRELVSGAADGSVHLWDIRSSDSVLSFANTEKSLRCLEVHEHAPIIATGSKSVNLWTSSGDLVYNLKNPHESSTYLGGRTSNYLSGVALHPHRMMVASNYNQDGNINVYTCVDIIQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZC1</accession>
    <name>G3AZC1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_119196</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZC1"/>
    <dbReference type="STRING" id="590646.G3AZC1"/>
    <dbReference type="GeneID" id="18248688"/>
    <dbReference type="KEGG" id="cten:18248688"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_1_2_1"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000074">
        <property type="entry name" value="Metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="213"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="674" mass="78232" checksum="3DB83D3C6EA2F8C3" modified="2011-11-16" version="1">MSEIDYDNLISKLSLPRWDHTPSQVLQKAEDLIRIQDECLNKFAAVENPTTENALAPYLQTVQEIWFSEGQLTFYSSVSPQKDVRDASNAVSKKLDKYSIEASQRKDVYKVFKKLAEAKHSDPETTRYLDKKVLGYQRNGMELPDDQQEVLKNYKLQLSELAIEFKRALNEIDEYIAFTREELEGVPDDVVDQFQIDGGKYKMTFKYTDFFPVMKYAKNQDTRKRAYIGNQSKCANNGTILLNMLKLRYRVAKLLNYDHYSAFVLEERIAKTSDNVLTFLHDLRAKLTPLGKQQLQHMKELKYKDLRSRELSPQDDFYIWDQSFYDNLLLEKEYQVDHKKIQEYFPLDLTIKRMLSIYETIFDIKFHKLANLPVEFTWHSEVKQFAVFQNIKSGNPSFVGIIYFDLHPREGKYGHAANFNLGPGFEKGDGTRQYPVTALVCNFTKPSKDKPALLKHSELKTFFHELGHGVHSILSKTKYAKFHGTRVPRDFVEAPSQMLEYWIWSQDELKALSSHYQTGEPISDELLGQLIKSKSVNRALLNLRQVFLGLFDMKCHTIDNEEDLETFDLLSTWNDMRGDISLIPADAIRTPGYASFRHIALGYSSSYYGYLYSQVFAADMFYSLFKKDPMNIQSGLRYRDVILSTGNSREIMESLEELLGRKPTNTAFLKELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZC6</accession>
    <name>G3AZC6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92409</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684635.1">
        <property type="nucleotide sequence ID" value="XM_006684572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZC6"/>
    <dbReference type="STRING" id="590646.G3AZC6"/>
    <dbReference type="GeneID" id="18250195"/>
    <dbReference type="KEGG" id="cten:18250195"/>
    <dbReference type="eggNOG" id="ENOG502QVCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022730_0_1_1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="472" mass="53146" checksum="4B140749A486DC2E" modified="2011-11-16" version="1">MPTEKQYFPLDGYTKSFWLGLEDQEEFSSHRTTRELPSEVDVLVIGSGYAGASTAHYLLHQDPALRVALYEARTACSGATGRNGGHVKPYYHRNYDLYLQMLGEKGAAEVVNSEYDHLWAIKKIVDDNNIDCDFFLTRACDVYPDKEDSRVARDLEAAKSMLANPHIYPEMKKQFQIFHGAAARMISKSPQTDIAFTYPAASCWPWKLFISILKMCVAKGLNLQTNTLVTKVTSTDNGKWVVHTPRGTTICGKVVYCTNGYTKGLLEEFSNTIVPQRGVCCSIEAADKDHTPHLTNTYGLFTSRPNSDYLINRPDGTIIVGGRDESLIKPNGDISGWFDCVDDTYVDEVSKAEFKDYMKKRFSTWENTDSDVSKIWSGILGFTNDYLPYVGELDVIGKKGCYIVAGFHGHGMPRVLFSAKAVATCITQNKKVHELEYTIPKGFFVSKERIEKPNVYEQGIHKFVKEHYDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZF7</accession>
    <name>G3AZF7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112946</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZF7"/>
    <dbReference type="STRING" id="590646.G3AZF7"/>
    <dbReference type="GeneID" id="18246749"/>
    <dbReference type="KEGG" id="cten:18246749"/>
    <dbReference type="eggNOG" id="KOG0416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_7_1_1"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000016">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="190" mass="21759" checksum="1037474D46F3DFCD" modified="2011-11-16" version="1">MSSPKRRMEKDVMDLMMSDHDVQLIDDNIQQMYVLFEGPEDTPYKGGTWRVRVELPDQYPIKSPSIGFINKIFHPNIDESSGSVCLDVINQTWSPMFGLLNVFENFLPHLLRYANPSDPLNTDASNLMSRDEQLYTQKVREYVAKFAQNITNDHSDWQDDNDKDVDEDELSDVGSLSSDDYDAVAGDIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZH8</accession>
    <name>G3AZH8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101294</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZH8"/>
    <dbReference type="STRING" id="590646.G3AZH8"/>
    <dbReference type="GeneID" id="18245456"/>
    <dbReference type="KEGG" id="cten:18245456"/>
    <dbReference type="eggNOG" id="KOG3057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133964_2_0_1"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="82" mass="9724" checksum="F412F1589352DCA8" modified="2011-11-16" version="1">MAIDPETFKFDTPQFDPRFPNQNQSKNCAQAYVDYHKCVAVKGEDFEPCKIFWKTYTSLCPLEWVERWNDQKEAGKLPFKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZJ9</accession>
    <name>G3AZJ9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101819</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZJ9"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_2_2_1"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="69130" checksum="E4FDD841312DF19C" modified="2011-11-16" version="1">MSQLEKTSLDESQPENISLPEKTLDNELGKETTSLNVESIKSDSDHGTFSGEYHPDDVDLLAPELTIDDSPTLLENFKLKVYKKPKNYYDQIATRKSVFEGPDPNIVKTYFPTSKWENFKAFDPYFRWTYAEDKAVTRKIDYKILPIVCALFFCLNLDRGNLSSAVAGGILVDLKMTTDDYNLGNNLRSIGFIITEIPSQMLAKKFGPDWWMPLQVIIWSIIALAQYWVNDKKAFWALRFLLGVSQGGFIADSVSYVSYFYTRQQTGPRLAAFWSLISLSGIISNLLAVGFLKVTVQGKASWRWLFMFDGIITLVFGIAALFLMVPGPTQTKSKLFPKGFFNEKEEKIITNRLIRDDPTKCDMHNREGITFKQFLKTLLDYDLWPLLVLSLTYQIAYYPMSAYLNINLKALGFGTDQILYLNLPIYVFEAFTIVAITLISEFFNERALISIFPQFWVLICVVVEFTSAEKISNWGQYAVMFFLISMPNIQPILTSWISRISYSVRARTISSPMSNIGIQLAQLISNNVYRSDDSPYYHRGNKALVGVTVMNIVLFALTKVYYIYRNKYKKGKWDSMSDSEKETYLQTHRNDGNKRLDFLFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZT0</accession>
    <name>G3AZT0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_97168</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZT0"/>
    <dbReference type="STRING" id="590646.G3AZT0"/>
    <dbReference type="GeneID" id="18250662"/>
    <dbReference type="KEGG" id="cten:18250662"/>
    <dbReference type="eggNOG" id="KOG0448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011752_0_0_1"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="119"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV65232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="774" mass="88463" checksum="5C8D38B35519ADEF" modified="2011-11-16" version="1">MKQLHYNENKLALDNLINKSIDLIYELANENKARPIFYPMSNTVVRADKSLKAFEKEKPKVSDADDGVDFKILKLNLQMSPHDLTNGLNNLDKSSISILLEQKLNQQVKFLLSLKDRIDDTSSKVFVTGDLNAGKSTFCNALLRRKVLPEDQQPCTSVFCEIIDASKDNNSVEEVHAVPHLSTYNIKDETTYQIFTLDDLEHLVYEQEKFSFLKVYLNDVRPKEQSLLRNGVIDIRLIDAPGLNMDSYQTTQVFSRQEEIDLIVFVVNSENHFTLSGKEFISSAAGEKQYLFIVANKFDNIRDKERCKQKILEQVKNLSPDSYKDAQSFVHFVSASDAFNAPEGGGDGDGDGPDNDDGFSNPDFDQLEASLRNFVLEKRAISKLLPAKNFLINILKDIRILSEVNQAQYIKEKEQKLHDLKDIIEPKYDGILNQSIVINDTILKLMEKSSSSIYQFTKDELNDSIDNLGDSQIVPYQGIQFAYAYAQETQRRMIDSIISAVNKCEEHSKMQTSARVEEIIKYGQETLGDEFLNDKKFQPELMFTRRRDLIKKNLIQPIELGDFFDPSIESCLSWIGLPNDLVSRGVGFLSDYNPTSIITKLPLTAITLREQLPAQLTLHTLYSSSKILTVGTILRKLYSFSHVLTPQMMKRVAGPVLLGFLGFSVYYLINDIPNAFPRKQARKMKGQIQDLEYVHNNADRISKECRKVLNYPLRQVMNNFQTSIDKRGQEKITLEEQIKNSELSLNYFNDLIEKIDYEFKLIANVNLENVNTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B080</accession>
    <name>G3B080_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Longevity assurance proteins LAG1/LAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_113057</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B080"/>
    <dbReference type="STRING" id="590646.G3B080"/>
    <dbReference type="GeneID" id="18246806"/>
    <dbReference type="KEGG" id="cten:18246806"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028277_4_0_1"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="166"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="413" mass="49125" checksum="18B3329578304A64" modified="2011-11-16" version="1">MTSSNLAPPNSNQVHRRRGSSIGNIDLGDTSPALSTMKTSKAQRRKSSDRMAQLSEKTTTDSQLLRKFYLSYRELTYRQTWIQPLIVLVLSVFIYLISNPEGQIHQFLEVCILPSYKIPGTDQYGKGKYDFYFVFYYAIFFTFFREFCMCMILRPLAHYFKITKESRVKRFMEQTYAIIYFGAAGCFGLWIMSKLPLRWFQTTPLYETYPHKTHDFWFKIFYLGQAAFWVQQSVILVLGLEARRSDFVEFVFHHIITIALIWNSYRFHFTWMGLTIFVCMDISDFFLGMSKTLNYLNAPGGEAFFVFFVFVWIYLRHYINLKVLWSVLTEFRTVGQWELNWETQQYKCWISQPIVFFLIAALQLVNIYWLFLILRILYRYINVGEAKDERSDDEDEADDEADDEEDRSEKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0A6</accession>
    <name>G3B0A6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance rate of mitochondria protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113071</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685206.1">
        <property type="nucleotide sequence ID" value="XM_006685143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0A6"/>
    <dbReference type="GeneID" id="18246812"/>
    <dbReference type="KEGG" id="cten:18246812"/>
    <dbReference type="eggNOG" id="KOG4147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117792_0_0_1"/>
    <dbReference type="OrthoDB" id="937at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16573" checksum="311AB784FE0E670F" modified="2011-11-16" version="1">MDTEEPLTSNVRPATDAVLTIRIIKSFPYRNVRNHIIHSINLKETTPQQLYEQMKQIINTTGGLRPYRNMEYDTLKLYTKAHGTKSMNLVINFENDKEFTILSPDVNPSQTLYDLGVENETEISLFKLSDYLAYKENPEEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0D6</accession>
    <name>G3B0D6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_97280</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0D6"/>
    <dbReference type="STRING" id="590646.G3B0D6"/>
    <dbReference type="GeneID" id="18250673"/>
    <dbReference type="KEGG" id="cten:18250673"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="288" mass="30376" checksum="309466E537C6ACFF" modified="2011-11-16" version="1">MDLDRTYLQTSAWKSNIFKGKVVFVTGGAGTICKVQTQALVLLGADAAIIGRNEAKTIKAAEELAKLRDGAKVVGIGNVDVRDVQSIANAVETTVEKLGRIDFVIAGAAGNFLSDFNHLSSNAFKSVVSIDLLGSFNTIKACFPQLRKNKGKVIFVSATLHYYGVPFQAHVGAAKAGVDALSNALAVELGPLGITCNCIAPGAIGGTEGMSRLTPPGQRPTETRVPLQRLGSTRDIADATVYLFSPAADYVTGTIQVVDGGLWHIGNMMGDLYPDVIISQGEDEHSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0U1</accession>
    <name>G3B0U1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein HSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113574</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S5B/HSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0U1"/>
    <dbReference type="STRING" id="590646.G3B0U1"/>
    <dbReference type="GeneID" id="18247026"/>
    <dbReference type="KEGG" id="cten:18247026"/>
    <dbReference type="eggNOG" id="ENOG502QWEK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_589245_0_0_1"/>
    <dbReference type="OrthoDB" id="4074002at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040752">
        <property type="entry name" value="HSM3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041335">
        <property type="entry name" value="HSM3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18794">
        <property type="entry name" value="HSM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18795">
        <property type="entry name" value="HSM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein HSM3 N-terminal" evidence="10">
        <location>
            <begin position="61"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein HSM3 C-terminal" evidence="9">
        <location>
            <begin position="325"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="478" mass="53966" checksum="E4A29BB2D91B4E20" modified="2011-11-16" version="1">MWLEFALFSFPPHSMVSAITNPYTHPDISDALSEAASNVFHQLDQGIVHKTDLELFNRLLINSTVPQSFVESLIPAIDQAVKAPDYYETDPDFVLIAIYETLLSKLPPATVLEYYPIHFITENIQYANQFSLLILKIITRNHSQIELVSNGLLHTILSLYLKDADVMIPIASAIQNLVLVLSDDHNIISELNTAKFKELFANAKTSGDSVLISRLLDLMVVLAPAVQFDLGFPIGGDVLLDLLKIDFYQNLINKENTHIFEAISTPVNRILALYNTRTTDAEIESFLATEIANLIASITFAFPDWELPGLKSYNLYLDLASDVLLLSKINPAKFDDDLLEFVVDYSLFSTKYFRILLNLVKSQKALHFLVQHDKITASLIKNLSLDMLFDLLVELTSTDFGVHYLLNSLPSIVTDFIINDSAISSDVYIAKLEVFEHLLFQDHDLTIWNDQLVDAYKLMKNGRNIRHEARVEIADEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B131</accession>
    <name>G3B131_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_104061</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B131"/>
    <dbReference type="STRING" id="590646.G3B131"/>
    <dbReference type="GeneID" id="18245677"/>
    <dbReference type="KEGG" id="cten:18245677"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014602_2_0_1"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF56">
        <property type="entry name" value="MEIOTIC PHOSPHOLIPASE SPO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="7">
        <location>
            <begin position="1"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="623" mass="69773" checksum="B10FDC4B53E6A385" modified="2011-11-16" version="1" fragment="single">LSEYENSYINQRHRSTQLSLKHVLKRNCIPGFEASQVLDSLSPVNIAIAISGGGYRSMLTAAGVLAAYDSRTPGSQNPGHLGGFLQATSYIAGISGGSWVVMSVAVNDYKPMVQLKDEELHAIEGRLLIGIPDFDPGFKGNSPKSEHIETREDGTVSSVLSYFGFNKKKGTEPRFSTKLLTMMENKNQISGENKIKDIYNFYESIHNQVRSKKKSGSYISFTDYWGRALNQKLFTSFTSRTFSSLKELPSMKSFAQPFPILCAVLKSPIQKETSQKSHLVEFTPEEFGSWDSYMPGFIKTKYLGSTIKNGFPVDGCKMGYDDVGFLVATSSSLFNNVFLYVYNYLMKVNHEEKTAIQTILSTFGLSSNYTDSSIPQHHPDYAIYSPNPFSEYEEAEDSISSQQHMYLADGGDDGQNIPFQPLLQPARNLDLILAFDMSSDLYNFPNGSSLTKTASRFHNSDATMEINTFSISGYKQAVFPKVPSAEQIKQLPNTPMFLGCDLIFDYPRLEGSHIKQVDGNFLPPLLVYTPNRHISYASNTSTFQLSYNHSEINQMFQNGYELATANNSTDFAACISCAAIKRKVDKMHFRQLPKALTMGLDLPEYCHQCLNKYCWHETRISTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B168</accession>
    <name>G3B168_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ClpS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_113651</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B168"/>
    <dbReference type="STRING" id="590646.G3B168"/>
    <dbReference type="GeneID" id="18247068"/>
    <dbReference type="KEGG" id="cten:18247068"/>
    <dbReference type="eggNOG" id="KOG1715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_0_1_1"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="104"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="171" mass="18159" checksum="21A4CA9DDD832138" modified="2011-11-16" version="1">MLRQFVKPCARLVSRRAVLPVVRFNSTAADAATASPKAAVDPKISAIVDQISTLTLLETSSLIAELKEKLNISDIALPAAGAAAPAAAPVEEEVKEAPEEKTIFSIKLESFDPKSKPKVIKEVKSLLGLSLVESKKFVESAPKVLKDNVAKEDAEKIKATLEGVGAKVTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1K8</accession>
    <name>G3B1K8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_92700</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685275.1">
        <property type="nucleotide sequence ID" value="XM_006685212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1K8"/>
    <dbReference type="STRING" id="590646.G3B1K8"/>
    <dbReference type="GeneID" id="18250222"/>
    <dbReference type="KEGG" id="cten:18250222"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010370_1_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="243"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="631" mass="72478" checksum="117AC816EA435ADD" modified="2011-11-16" version="1">MEIPLKSQAKVSLTDIRKLDNSKYHIDNDDTLDTYDDEHQLNKLTRTYSETEVNNFDEETGHRLYDDELFRPKRTYMDQETESGISRLYSRSHGRPFGIEDEYIPGLNFSDMVYKWSDTPDLSRTNSTSSFLDLDDLHARVSPKKIFQGSLTSMSLKRMKTSQSDFDMILDSLPSNFNDMPYSQRKKVVKSINENVDYSQFSVYMKNYFGKKTLAGRLLSSTTDLKKIVPLNVDEKGARVMEYTLGKVIGFGAWGTIRECFDNNQNPYAMKIVSNKKMSVINLFKREIMIWEQLNHPKILKLFKYLETEDSIFCLMDRIKGGTLFELVSKWGVIEGNEDFSEDAQSLGGGPIRPVRSAQSISSFSIPSSRRVELVINFTRQIVKGVQYLHNSGIVHGDIKLENILVDKTKEAEDDWQMIICDFGMSRFYRSRSSTEIRSKSSMSEVRKPYKGESLHSRLLLNELNEKSRSRNNLSIKSMSRSNSPSKSEPTSSSSLESIKKYVREMKAKELKRQSQVDLDLPDSHIGSLPYASPELLLPNPPPLGPSADIWALGILIYTMIMGRLPFQHFYEPRLRAMIIKGKFNRKDLENVLKDHEWVNGLITGCLESDITKRLDIDLIDDMIERNTNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1R5</accession>
    <name>G3B1R5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113280</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1R5"/>
    <dbReference type="eggNOG" id="ENOG502T5JW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171955_0_0_1"/>
    <dbReference type="OrthoDB" id="4086878at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11213" checksum="8AC1E784D0AB74F6" modified="2011-11-16" version="1">MAPKVAKAYQPPKDRISKSRVFSSAVITLLVLGLLLLWGYNFLWAIRVVRFNYYGSLLLNFVIAIGSLIANATISLRVLRYLNETLIGDKIDADHKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1X2</accession>
    <name>G3B1X2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_120163</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685356.1">
        <property type="nucleotide sequence ID" value="XM_006685293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1X2"/>
    <dbReference type="STRING" id="590646.G3B1X2"/>
    <dbReference type="GeneID" id="18248757"/>
    <dbReference type="KEGG" id="cten:18248757"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="540" mass="59148" checksum="2E784F9E63F73486" modified="2011-11-16" version="1">MSDLEKEISPSGSVQELRDAAHHNALVTEVMDKQITKWEAMKRHPYACFCILTMVWVLISTSFESQAGGTVISIGVFREDFGHLVDGSYVLRSTDQSILSGVPLATQIVGQWLGSWLADKFGKKWVIYGGMLTSCAFVGMEFAATTMGVFIAGKTLNGFSLGVIQASCVSYVADISPLPLRGLSTALCNISFSIGPLVVFIINYCVANFKTRWAYRAMLSSQWGFAAVSLVLMLLIPESPTYYILQGKVDKAEQAYRRLLGDPVAAVNQVTVVKETVLEAEKISEGSTYLDCFKGVNLKRTMVSCVPFMSTSFSGVAFTGSYTTYFFQLSGLDEQKSFQYTCGAQAISIGGCIASLFIVDRFGRRNNLIYGLLSICLCDLIIGATATASDSKPEVLNVCIGFMMLYGGIYNAGLGSVCYPICAENPTSALRTKTVALGLASGNLFSMMWSFVIPYVFNPDQANLGGKTMFIFFGISVLIWVHIFFFQTETAGRSYDEIDEMYASGIPLRKFQHYTSKLANIDVGLTEEEKAVQVKHVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2F4</accession>
    <name>G3B2F4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_113448</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2F4"/>
    <dbReference type="STRING" id="590646.G3B2F4"/>
    <dbReference type="GeneID" id="18246963"/>
    <dbReference type="KEGG" id="cten:18246963"/>
    <dbReference type="eggNOG" id="KOG0455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_0_1_1"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="11"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="149"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV64660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="360" mass="38479" checksum="2FE839EF54E3D9F5" modified="2011-11-16" version="1">MAKSVNVAIIGSGVVGSAFINQLKNLKSPIDFKVVYLARSSKEAVFSKDYSPVDLSTYKSATSNPVLPLAELADYLSAAARPTILIDNTSNESIANFYPTFIKSGISIATPNKKAFSSDITTWNDIFSSSAQPHGGLVYHEATVGAGLPIIGPLTDLVLTGDKVDKIEGIFSGTLSYIFNEFSTTDASNNTKFSDVVKVAKSLGYTEPDPRDDLNGLDVARKVTILARISGLKVESPTSFPVESLIPKPLESIQSAEEFLQKLPDFDADIQKLKDDAFADNKVLRFVGSVDIKTNQVKVGIGKYGFDHPFASLKGSDNVVSIKTERYPNPLVIQGAGAGAEVTAHGVLADAIKVAQRIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2N1</accession>
    <name>G3B2N1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_103630</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2N1"/>
    <dbReference type="STRING" id="590646.G3B2N1"/>
    <dbReference type="GeneID" id="18245645"/>
    <dbReference type="KEGG" id="cten:18245645"/>
    <dbReference type="eggNOG" id="KOG2289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022618_0_1_1"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="197"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="445"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="535" mass="60088" checksum="9A8FB5A89A425E20" modified="2011-11-16" version="1">MNSIHSSPVNPFSNQNDYDRYEDKKFQHQQYPYDESPTLHQNPFENPPVSYIPDKAQPPIPDYDEEKKLKHNERQRLKQLRSRPRFHYTRLPYFGILVTIIQVVVFIVELAKMAKLTGSAFQTKPYFNPMLGPSTYVLINMGARYIPCMNGVEGITTDPSIQYPCPNSTSVDTDVCSLNQLCGLSGIPIVDDAYDPHQWYRIITPIFIHAGFLHILFNLLLQVTMGFSIERAIGSVKYAIIYLLSGVSGFLLGANFTPNGVASSGASGSLFGIVATNIVMFIYCGKKNTNMYGTKKFGLFLCIMFGEIVVSFVLGLLPGLDNFSHIGGFAIGVLSSILLLKDPFFVYEDGIITYQSHLSIWQEFANNWNPYYNFEDKIVSRFYIWCGVRVLCFALIFVYFALLINNFFGKSILPEENSCHWCKYISCLPVNGWCEQGELSVQTNSADDNSQSTTASATTSTPTSATSTEPDSIDNTGFSEPNKRETVLDSVFESSTFENSTPLLGRHEESIHASLALFIIMGLFTFTALKFKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2Z9</accession>
    <name>G3B2Z9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_105554</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2Z9"/>
    <dbReference type="GeneID" id="18245820"/>
    <dbReference type="KEGG" id="cten:18245820"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="475" mass="52752" checksum="6A430E953C48F528" modified="2011-11-16" version="1">MNSEVDPAESARVARKIDWHMLPILCILYGINYVDKAALGWAVLFTFKQDLGLVGTDYSWVSSIFYFGYLGAQYPASYCLQRFPAGKVIACTTVGWGAIMLGHIGCKNYAGILVCRFLLGVFEAPISGGFVLFCSLFYTRKEQVGRTMVWGSMQGIFNVIFGFVSYGLGHAHNSSLKEWQLIYLVLGLCSFVIGGLWFAFIPDTPGKARFLTEDEKVIAIKRVSKNMMGTATHDWKWSQTLECLMDPKTWLMVAFILFSMIPNGGLTNFGSLVLADIVHNNLESIAVGVGSSFFSAGQMLIFSIFAIKYNNFRTIGMTFPMLLAIAGLSAVYATETHGAKWGRVFAYWMINSYAVTWPFTLSMLGSNYAGHTKRASMSMILLIFFAVGNIIGPFCFTSADAPKYTKALATNLGCFCACFVIGVGLRVYLMYANKVRDKKYGVVDAEINEDKRLEGILNGMKDETDIKNKSFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B347</accession>
    <name>G3B347_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 5'-monophosphoramidase HNT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidine triad nucleotide-binding protein HNT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_114113</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B347"/>
    <dbReference type="STRING" id="590646.G3B347"/>
    <dbReference type="GeneID" id="18247270"/>
    <dbReference type="KEGG" id="cten:18247270"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000013">
        <property type="entry name" value="Hit family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="12">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="10 11">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="149" mass="16698" checksum="3AF24FE407848832" modified="2011-11-16" version="1">MSSASCIFCKIIKGEIPSLRLIETKYTYSFLDIQPTADYHCLVIPKFHGAKLHNVPDEYLADILPVVKKLTTVLGLDTNNTPDGEGYNILQNNGRIAHQVVDHVHFHLIPKTSDSTGLGVGWPAQETDFDKLNKLHAELKEKLAKYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B364</accession>
    <name>G3B364_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_105553</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B364"/>
    <dbReference type="STRING" id="590646.G3B364"/>
    <dbReference type="eggNOG" id="ENOG502S2ZP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051199_0_0_1"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="273" mass="31170" checksum="DF03830791A1DF7C" modified="2011-11-16" version="1">MLPLVAAQFYPLTKNGEIPLALEPYQEGQNIYMDCISRQIDTGEHKQDSQDRILYVPFPPCKETGLPLMFKYNVNEDLNCTISFTDELYHLFQLYIHEDVPFNCRVPLSTEQNYLEKGGAYIPLNFNFRGEIHDSHLDIDESMNVIFVKPRKNELNTLISSIAFSSSTNATRIVIGEDLTLKLAVRWFDNLNAMDSVTLNYRERNGLPFVDGFYSFPVNILPITYTAFLGYMTLVAMVSGMITLAFAYNIISIKFAKNKYLAIDHEAGVAKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B392</accession>
    <name>G3B392_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_122256</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B392"/>
    <dbReference type="STRING" id="590646.G3B392"/>
    <dbReference type="eggNOG" id="KOG1008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005843_0_0_1"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="431"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="825"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="804"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="910" mass="102066" checksum="B8C2C88E2122E71F" modified="2011-11-16" version="1">MSGTIIRANWDNGQHTQHFVAVTPLGDEIILYTTDADTISPTVSRGGFDNISCSTYSQFQHGFTAVGQINGTVGVLDMTDNSSTVIRLRPKQSRPCNAVSFSHSLVAAAFDKGRQDTSLQIWSLDSESRQMPVHSYVPNEAVLSALFYPDRPDHLLCGSYKYLREFDIRAEVPAFQLAAKCTLDLAVDPFQPHNFSSSGEDGSLALWDRRMLTRKNRESPVLQFNKLLDTSRKNARPCLRYSPVRRGEFSSIFNGELIRRWHTGVAQSAQLYRPDHDSLFVSLVLDVKADYSRVISFDYSPDARAATSTSFVCMRQSGSVFRMPAVECIESLDFNSNNEFSIVGPEGAFTRFLDEPAPGPPSRANDLSLSADLNRFREENTPPVVDGDENTEIDDENTDNIENGHDLNDHAAVWNMLGTSDMLRNDICWTIRRRAVLGYSHDCELNIRVLESIDDIDNQLALRNTWKWLSLAKKSLDKGTMVSHGVDLGFLGVIGIWNGIEKLTNPKRFNTDGPLSEQFFAQTIKAIVSSKGKKAAAIHIPSASEHKAQRKLCLIVSGWYFSDEEFDERLEILVSLGFYEKAAGWAVFHGHIDRAVSILSSSPKERLRIIATAVAAYLAYRDSNVNSPWKDQCRKMASELDNPYLRAIFAFIADNDWWDVLDEHSLPLRERLGVALRFLSDKDLTVYLHRLADYVVTKGELEGLMLTGITGRGVDLLQSYVDRTSDVQTAALMASFGSPRYLVDRRIDHWIDSYRGLLNSWSLFKTRATFDVHRTRLSRTSTGVPTLSAVPKQVYLQCPRCSKNLSTRGQSKPKPQLPPRRATRNDTNSCPHCGAQLPRCSVCLLSLGTPVPFETSVTPASASLIENRFREWFSFCLSCNHGCHAFHAEEWFAKHYVCPVPDCSCQCNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3A1</accession>
    <name>G3B3A1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_114146</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3A1"/>
    <dbReference type="STRING" id="590646.G3B3A1"/>
    <dbReference type="GeneID" id="18247287"/>
    <dbReference type="KEGG" id="cten:18247287"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_2_1_1"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="93"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="547" mass="60651" checksum="DCFE9702E2CE0769" modified="2011-11-16" version="1">MLVEAASRLNVRTRILDKGLSPAKQINASEVHVDGSFTDYKSIKELALQSDVLTVEIEHVDVAALEQVRVETGIKIYPLPETIRLIQDKYLQKEHLIKHDIQVVESVALNENSREEVLKIADKLGFPLMLKSRTLAYDGRGNFVVKTKDSIEEGLEFLKDRPLYAEKWCPFVKELAVMVVRSIEGEVFNYPIVETIHKDNICHLVYCPAPVNASVMAKAEILARNAIKTFPGCGIFGIEMFVLENGELLINEIAPRPHNSGHYTIDSCVTSQFEAHIRAITNLPLPKNFTCLTNSSVHSIMLNVLGDKEHNKELQVCRRAMELPNTSVYLYGKTSRPQRKMGHINVVDTSISNCERKLDYILGEATSYEVPVEGDQKPLVSIVMGSDSDLVVMSQGADILKKFGVPFELTIVSAHRTPIRMQQFAMQAQGRGIKCIIAGAGGAAHLPGMVAALTSLPVIGVPVKGSTLDGVDSLHSIVQMPRGIPVATVAINNSTNAALLAIRILGTDDEKWLNEMNQYMLNMESEVLTKVERLERVGYEKYFSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3D7</accession>
    <name>G3B3D7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SsDNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114169</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686694.1">
        <property type="nucleotide sequence ID" value="XM_006686631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3D7"/>
    <dbReference type="STRING" id="590646.G3B3D7"/>
    <dbReference type="GeneID" id="18247300"/>
    <dbReference type="KEGG" id="cten:18247300"/>
    <dbReference type="eggNOG" id="KOG2712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144950_1_0_1"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="106" mass="12314" checksum="B7ADE8FE3349BD07" modified="2011-11-16" version="1">MSTKRKDETSEPSETVIPLDNYKQVTVRRFKTMNLVDIREFYVDKVTKEKKPGKKGISLTEEMWKKLMASQHQIQEALDQLNSEPPAKKVKQESISKKTVNDSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3F1</accession>
    <name>G3B3F1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 12">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_114183</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 12"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3F1"/>
    <dbReference type="STRING" id="590646.G3B3F1"/>
    <dbReference type="GeneID" id="18247305"/>
    <dbReference type="KEGG" id="cten:18247305"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
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        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
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    </dbReference>
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        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
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    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
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        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
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    </evidence>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023004"/>
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            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00034128"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00048403"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV64386.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="416" mass="47159" checksum="D78EE05445D41995" modified="2011-11-16" version="1">MVEPTQEVATTTPVKEKRRFVGRKATPADGKSLVKTSRSKVISRVMNQIPEDILNNKDLNQAIKLLPSNYNFEIHKTVWNIRKNNAKRVALQLPEGLLIYSLVISDILEQFCEVETVVMGDVTYGACCIDDYTAKALDCDFIVHYAHSCLVPVDVTSIKVLYIFVTIHIDEKHLINTIKLNFTAGTNLAVFGTIQFNPTIHSVKAKLEHDEEHPVYLIPPQLKPLSKGEVLGCTSQRLDKNHIQGMVYVGDGRFHLESSMIHNPDIPAFRYDPYSRKFTREYYDQEQMVQVREDAITVAKNAKTVGLILGGLGRQGNPVTVGNLEVKLVQYGYKVVRIILSEIFPQKLAMFNDIDAFIQVACPRLSIDWGYAFNKPLLTPYEAMVMMEADKKWDTFYPMDYYALDGYGRGKQPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3H4</accession>
    <name>G3B3H4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114211</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="6">
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            <end position="60"/>
        </location>
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        <location>
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            <end position="198"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27166" checksum="73698B2BAAC6724A" modified="2011-11-16" version="1">MKIVPGDALDIQQMKTTIGPGVYKNPKTQNIIPAAAGYLNVKINKKNTNQLAYIESKSKRYIPKANDFVVGIVTGTIGESYKVSLQDFSANVLLSMMAFPNATKKNRPNLKVGQVVYARVSQDIPEIDIEIECIDPATGKEGGFGMLDESGYIFEVGLNYANELLFNPSSVYLEKLASKCKFEVAIGLNGKIWIKCGDGLVYEEDQLTEAGANDFRYTLAAATYLKKCQKVPKSQVDAVLKESFKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B414</accession>
    <name>G3B414_CANTC</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_121753</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006686163.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cten:90982143"/>
    <dbReference type="eggNOG" id="ENOG502RPUK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428252_0_0_1"/>
    <dbReference type="OrthoDB" id="3981301at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="639" mass="71043" checksum="88E0E109E45C8A1D" modified="2011-11-16" version="1">MSSLPNATYLSVTPNSSGGERVHRHRRSAAISGDFDNFGLGLFSPSSKPNNKDDDTDAHFNFNNDDDFAKSVSDFSFPNSKNYDNFMVSTPPRYFNSNGRKNLHSPIKLNQKRAFNKKSSNSNLNSNHPNTPKTKFFLTEETNLNNDNVPDAVIDLDEVLNANLHIGDYIHRCQKEKDDVFFDDEYLSSPFLKPLSSSPYTFSPSISLPNTTLLQQPIQENINDDIENSHDDDAVIGIDENEVLYNPPNIAGEVYSNSSTNSSCSSLKRQSVEKIMSNSSRDSNTSPPIVNHNIVNSTPKRSGAKANRYQSFYDQSFKLSNALKSSESVNLTKPNSPKHVNMTLYMSSNNSSTLHTPPHQPQSQPQGLSQAFGQPKFYKESSRLLAHSSSLPVLQSQRGMPKYQRHGELRTRYIEINKLSPPPSIQSATSGSPTSSPSKGTLPKFIQKDNRIEISVTSPQQQTTSNSPISIISDTNSTMTSNISTVQSTDHSSFVSDSKEREKERALQTPPMIVVSNEKDSNDIETVRNSPVFMSSGSKPSSPTKRTPRRPLTPNEQKVIQETRIPPFKANMHQKSAKKPSEFKVPAPKRINDHSKSKSLSMVLTDLAPKLSKSTSTLGDDSSIKSNKSSKLISWFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B469</accession>
    <name>G3B469_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113831</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686105.1">
        <property type="nucleotide sequence ID" value="XM_006686042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B469"/>
    <dbReference type="STRING" id="590646.G3B469"/>
    <dbReference type="GeneID" id="18247137"/>
    <dbReference type="KEGG" id="cten:18247137"/>
    <dbReference type="eggNOG" id="ENOG502RJBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_710016_0_0_1"/>
    <dbReference type="OrthoDB" id="4019110at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="467" mass="52656" checksum="3168D05CCF65BD96" modified="2011-11-16" version="1">MSFQSHGKKDVRIVSDLSRFEFESPTPRNRSRNTTPTSLDEKPSVIDLDHEFKPKNTTDLPSSFFDSDIAPPDPGPRSRRTLLEIAEANNALPKVRDNNIDYSDIYQYYEKESNASFAAEPSRNPDFAPYPSSIKGGHSGNAPPLTIPTASNEYNNSKTPFTNQTSMPSAATPQFTNNGFSNAHNYKDKDLPPIMDPTQYYQHNHNGSSLIKSIDANSMTSKQKLMEDHLVKSVMHRPLFKIPARKLLKNDDFYEEKDITITLNFVLYFFEMIVSIIIVTLSSVLLNTDDNISVGIYRFFIADSSIALIVSLLFISTLINFEKRNGSFYVTVSLILSFVSFVITISTILPSDSCATSSICSVRKANSAFIIISMFLWLCDLVSFLTILYISRMNLLTDLNFDFADKGLQAEYNASVSSGYNEKDNDLIDPTSGQPLREYYLNEMGEMFEMTNDFDVRGKTKIIVYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4I5</accession>
    <name>G3B4I5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_130224</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4I5"/>
    <dbReference type="STRING" id="590646.G3B4I5"/>
    <dbReference type="eggNOG" id="KOG4288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055314_1_0_1"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="253" mass="28662" checksum="C77B69A3E3E8DC27" modified="2011-11-16" version="1">MSIAVFGGNGFLGRKICEYGIRNGFKVTSFSRSGIPPLKSNQHLQQVKWESADIFDDSTYKSQLSEFKTVFHSMGKIFEDESYKKDISSGGLNLNFVKKLIVGSNPMDKTIHNSYNGLNKESALKLAFAYYKANKNGKLVYISADKGLPVIVPSDYIRSKREAETELLKSKLNSLIIRPGIMYDEDERNNRYILVNGMKQLHQLKQQALGNDLSCVNNTIRPILSTDQVCSRIFQNLHEDNTVITLEKLMKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4P0</accession>
    <name>G3B4P0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114023</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4P0"/>
    <dbReference type="STRING" id="590646.G3B4P0"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331789_0_0_1"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="66"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="206" mass="23001" checksum="40491F5BA1B55058" modified="2011-11-16" version="1">MRSAYPTPSSLQSIHKPHLHSLNALPPNCSHGVRTTHSITKVSYQSHQFCRFIFTPHKPFCAMNTLKLGKTAPRGLKNIYMPTRRAFSYTSTLRAVEEVTSVNQFKDLIADDKVAIVDFYATWCGPCKAIEPVMEKLSERVPQASFLRVDVDQQAEIAKEYGITAMPTIKFYKDGEVASTVVGANLKAIIDSIKTYTGVDLMKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4T2</accession>
    <name>G3B4T2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metallophos-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_104725</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4T2"/>
    <dbReference type="STRING" id="590646.G3B4T2"/>
    <dbReference type="eggNOG" id="KOG2863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005893_1_0_1"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="13">
        <location>
            <begin position="264"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="406" mass="46596" checksum="8D8947E854D4C311" modified="2011-11-16" version="1">MAIKTLKIAVQGCCHGELDLIYSKLIGKKVDLLVITGDFQALRNNTDLNAIAVPSKYKSLGHFHKYYSGQKRAPIPTIFIGGNHESSSYLTELKYGGWVAPNIYYLGEFGCLWYKGLRIVGASGIFNYSSFLDNRIEDVPLPYTPSTIRSVYHMTPMNYLKMMLIQSELNIDIVVSHDWPQYIYHQGGLDGLLKKKPFFKDDINSGRLGSPLLKNVFNHLRPTYWFSSHLHVKFEVDVPGHQQLQKTKNTDEIDLDMGMDDTEEEEESSSSSTHFLALDKCGKHRRHLEIFNVSVDKNHISFDKDDFYYDRRAIVINKLMGRFVVSDKGKQIKPKELLDSSYTIKVLRVLNQEIEEELNSLSVNPEDFKVPFNFKVIAPSGLISPDLQFWPNNQTEEYCTKFDISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4T7</accession>
    <name>G3B4T7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor IWS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transcription factor iws1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_93373</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4T7"/>
    <dbReference type="STRING" id="590646.G3B4T7"/>
    <dbReference type="GeneID" id="18250284"/>
    <dbReference type="KEGG" id="cten:18250284"/>
    <dbReference type="eggNOG" id="KOG1793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045275_0_1_1"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="10">
        <location>
            <begin position="210"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="397" mass="44998" checksum="A4CF330C4AC95EF2" modified="2011-11-16" version="1">MSETEDINDMFKEEDVNDQFPDIDPDLNSDGNEDDQPIDNDKEVVSSNENDIGEYDEDVYTIQAHRNTEGATKQTKKKNIRRSKVTRTSEPVGAPAPVADYGDDNEQPTDEFANEDPASRKRRLLEEKMTAAIKKTATKRRKADEDDLERMQDDKIDYLKDKMIKAANSDAEKNLQGSVATEKLKMLGEVINVLSKADLAISILDNNLLEAVRLWLEPLPDSSMPAYQIQKELITALVDLPIKTDHLVASGMGKVMVFYQRSKRTEANLKRIVDKLIGDWTRPILNKSDSYKDRSIQFQEYNKTKFSNKLSSSKPKTQEAKTLYEESAERRNRAAIPAARTTAYKIAPKVNPEVLQRKFNGGGNSDERFKRINQKLNLKKKINKKSGPSIEGRNLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B586</accession>
    <name>G3B586_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114483</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B586"/>
    <dbReference type="STRING" id="590646.G3B586"/>
    <dbReference type="eggNOG" id="KOG0554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="148"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="482" mass="54916" checksum="8AB650EA7576A629" modified="2011-11-16" version="1">MFVRTVAWVSTLPRTIQQMLEHPPAVGSRLQVAGHVKSIRKFKNIGFLDLSDGSTYKTLPIVFRHPDQVLAQYDLKVGQSLEISGDLAESKGVQSFEVTFDPADDSHHLKIIGNVQDSYPIQKKETSLQFLRSIPILRHRTSTLASVLRLRSFLEHELNVFFAEHSFTKVTPPMITSSDCEGGGEQFTIEPLNPKEVVKDGMAVKHEFFGKPAYLTVSTQLHLEVLAPSLNRVWTLTPCFRAEDSNTNRHLSEFWMLEAEISYISQLSQLTRFTEVMIRHLTSQLSNNREDVLNSRYNKADRELIEVRWNSILAENDWPVITYDEAINLINQVKLKGRSKGRLAWGDSISTEDEKWLAGDHFHSPVFITDYPKSQKPFYMPHSKNYNISAPTVACFDLIFPFIGELIGGSLREDNYEVLVAEMNRRNMDLVEMDWYLSTRLNGSVPHGGFGMGLERLMLYLSGLENVRDVVTFPRAPETCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5A6</accession>
    <name>G3B5A6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_98341</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5A6"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="130"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="573" mass="64215" checksum="C67119D3629437AC" modified="2011-11-16" version="1">MSYHSNNSSSLELDDDNQPFAYKTETNTDARSETETYQSLYDKGIASNIPDKDLNAPPVSNPIFPEEYRLETETGLVKVETLHSLGRRQSIISEKEEDHEEYDPEIEFVTFKDRDPENPLNWSLKIRTLYTLIFSLLVIQAAYGSSSLAGGLPLIDEKFGVSTEVSTLAVSLMVLGFSVGPLLWAPLSEQYGRRPVYFFSFMLYVIFNIPVALAPNIGTVLVCRFLEGCFSSSALTIVGASICDIHNETRGLAIAFFSFCPYSGPVLGGIVNGFISVYSSRYDLMCWVNMAFAGVMWIAVSLVPETYAPVILKRRAKKLRKETGNEKIMTEQEARPMSFNELLNEVFYRPMKFVIQEPVLVLVCAFIALIYALLYAFFFAYPVIFGKLYGFNDAKVGLMYIPILIGAFLALLVTPLLEKSYNKMIRRRKPEPEDRLVGAMIGAPFPAISLFILGATSYKHIIWVGPASSGIAFGFGMVLLYYSLNNYILDTYHKFAASALGTKVFLRSSGGAAFPLFVTQMYNKLGLQWASWLLAFVSLGMMLIPFAFYRYGRGLRAKMCKEDYSANLQMVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5E3</accession>
    <name>G3B5E3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_135034</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5E3"/>
    <dbReference type="eggNOG" id="ENOG502SCJR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309934_0_0_1"/>
    <dbReference type="OrthoDB" id="4016549at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="663"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="950" mass="107368" checksum="F1086EA3D837B875" modified="2011-11-16" version="1">MAQANATLTYLPMDLISRIQGRFPTGPLSGFDPDASKSYDPIWKSLLKFQPPTTSNIESKDNTLPIPAYSQYLTELLNAMVNGIESQRPMFESSIFTLTTSIPTLKQNEYFNSKRYPDNYLSKILIDNFEQIQSCILTYSNLNVSSHLTKFLVNLIYSLQFWEVYHLINYLPNFKSFLVLLDFDIVETYETLIRPPKNYLEKNLYQGFQYPFPYPFYNFSYHTLKDNVEQKYADVHITPYIDIRLRKNPPNRRYKKKTQRLKQQGYTASKYDEKIKQEPAKISETIQIGNQKSSYAANEINESVTQQPEFNRMAPSTEDMQSSPFTATPALNFPYSQQHNFGYQLRPLQPPPVQMNYGQPGVFGVSQGMYLPPVAKAQGLYPYMPFAPMKPNDQIQSQPSSQIPSPLQQEVQPIQPQVPLMATSSAQTKPQISPMQPQSHRETQLQNQPERQQLDHSLDQSEIKSAVPNAQPVPCAPPQSQPEVPIVSPVQTQTTTLPQTSQVVDSGAGDKREVVHTETYDSSSVSHDPPSGHKSPKQAPALRWRQNYVAPQEHVRPEVQEDVHKPLPQGALEDVFQNGSTNVTLKSGSGRNDAGVFQGKFSEIEQSSSATLKQENDIYGSADASGDYDSSDISSDEEPYEKAIRNPDRPIVKYKPRATQVIHQCHLLDPTSYTPCLKIFYGKNELLRHQEFVHATRKKIYKCLYCSRNGSKIQSYPRHDSLARHIRRKHGVTGKENKLAVNYAKENVEIIEDPNRTSQGELLEITTRPLPHPQFLNEDFTLKPNYAGFLSFNTRERLNKKDPKDTESSDYGNEGAVSDSRASTSPDEGNLAANSGTENHTAPPTGKYTYPGGTVPYSYMASQFPYSQQQIPITNQMGSSQQFNPSGGYLNLPQMHKPPVQNSVRMPTSTPTSDQRSVPAPGFQGPIISFASNYYTAKEEERDEKKQNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5F2</accession>
    <name>G3B5F2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_130718</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5F2"/>
    <dbReference type="STRING" id="590646.G3B5F2"/>
    <dbReference type="eggNOG" id="KOG4438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025461_2_0_1"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="13">
        <location>
            <begin position="29"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="14">
        <location>
            <begin position="312"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="198"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="376"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="495" mass="57741" checksum="DF4540FAD2B00DAB" modified="2011-11-16" version="1">MSRPSQLFRNRNSTIHRRRTSLLHDDHHLSFPILDAKEISHVLQACDFDVLEDMIQRPNGQFMSSLTEKLLDTFTSASVEILNEQVKQTAKKDKFEANGDAHTNGASSAKNENNESSDAPVNDDTTQSLGVVVFARKAGEFFQTCGIYDFSLIDMVRPEPYRTRRILSAVVNFIRFREDRASEIEGLATSAYDGLEVLRQTEVENIELSNKINIMKDRLERNIDENGKSKPTLKEVNVYNSKMENELRKLKKVQESLTEDHFQYKSDKSRLIQNLEDINYVMLNQSKQIELLKDYDQVDVNSLHTIIDQLRSSATESSEKLSSLELQNRNISITIDSFNVVENDLKNLFRILEEVFHDVEKEEQVSDTLTRIQETMDQQNFESTDLQRQIQQIKRQLINIREKTEKLETQSEEKSKKSQETIDQLKIEYDDTIKERNLKDQELEKLRDQISHIQNDMKVRKMELEQEINNSEMAVARLNSHLRLYLTEMNKKIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5F7</accession>
    <name>G3B5F7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114522</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5F7"/>
    <dbReference type="STRING" id="590646.G3B5F7"/>
    <dbReference type="GeneID" id="18247463"/>
    <dbReference type="KEGG" id="cten:18247463"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021544_4_0_1"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="444" mass="50451" checksum="CF2886C377EEADA9" modified="2011-11-16" version="1">MKVIDLLDHDPSASVHSLPSEVSIKLTEISKVIFKSKKATLLTGAGISCNAGIPDFRSSEGLYNLVKEKYPKTVVKGQDLFDISLFRDELTLQVFCTFMEGLYASSLQAKPTETHKFIKLLKDKNKLLRCYTQNIDGIESKVNLTTGIKSSEFQTEETNRRLVNSSFNKNWKNLDVVQLHGDLNQLTCTQCFSNFEWTKKYQNMLSSGDNPECSNCFQKYQERLYSGKRLTGNIGILRPGIVLYGENHPQSEILAQGLNTDIKSRPDILIIMGTSLKVDGVKKLVKSLATSIHEKGGKVIFINKTQVSSSQWDNYVDYQVLCDCDNFIKVLKQEIPDLFLTQEQLDSKRLKQLEAKRIKQEAREEKKIQVKKDPQVLVKTPPPTPTKRKPARPVLKRRDFNSERSVKFGLKYELPSPPTSFNNDVVVTNQESDFTPNKKIKTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5I6</accession>
    <name>G3B5I6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_130738</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5I6"/>
    <dbReference type="STRING" id="590646.G3B5I6"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_0_1"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442538" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="17"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="79"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="327"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="665"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="885" mass="102285" checksum="393B1BCABD60F020" modified="2011-11-16" version="1">MQIFAIFYWFCLVISAKQYLFKSCEENGFCKRNIDYCRNKLQTKISNYFIEDAIEVGSEYAVISGLLTKKLPNSDVKLPFQLSFLENDNIRFTLDENRNVDLNINANRFKASEHVLPHELRLKDSTSITIHDGAEKILLLYKDFKIEVFVNETLQMTINEDKFLNLEHFRNESDNQQQLLPEESDFNMFRDNFKDSTSDKLPLGPESIGLDFNFVDFHNAYGIPEHSKGLKLEEEIYRLYNVDIFEYEVDSNLPMYGSIPFLLVSKPRLSMGLFWINSADTYINLSKPKSGAKTHWMSENGVLDFIIFFGESPAEVNKKYGEITGFPTLPQLFALGYHQCRWNYNDQKDLLEINSLFDEHQIPYDSIWLDIEYTDNKQYFTWNSNFPDPSGMLDELDLTGRNLIIIIDPHIKKGSKVSNHLQKNGLTLMNSENDTFYGHCWPGESLWVDSFNPGSQEYWDELHRLSPENKVFFDNTNIHLWNDMNEISVFDGPETSSPRDNLQYGGYEERSLHNLNGRKFHDMTYSSLSKRLESTQRQRPFVLTRSFFAGSQKSAAMWTGDNMSKWEYLKLSIPMLLNNGVAGMPFGGADVGGFFGNPSKDLLTRWYQTGIWYPFFRGHAHIDSRRREPWVPGEPYTSIIRDAINLRYTLLPEFYNAFRESSISGMPILKPLFYESQKFSKNYDIEDEFFLGNSGILVKPVTEETTKEVTIVFPDSEIYYDFTNGKISSRYHTQSVKVPVTLSDIPMVIKGGSIISRKMRYRRSSKLMNHDPYTLVVAPSSTNSASGSLYVDDYESFDYKNGSFLVANFELKNGKLTNKVTGTFNAPRRIEKILILNTHATKVEHDGASLRFKSIDGNLEIQNPGLHINEDWNIVIKKDLVHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5M6</accession>
    <name>G3B5M6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTEDRAFT_94029</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5M6"/>
    <dbReference type="STRING" id="590646.G3B5M6"/>
    <dbReference type="GeneID" id="18250352"/>
    <dbReference type="KEGG" id="cten:18250352"/>
    <dbReference type="eggNOG" id="KOG0454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_1_0_1"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="21">
        <location>
            <begin position="10"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="22">
        <location>
            <begin position="549"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV63265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="780" mass="86300" checksum="508105C1278D3694" modified="2011-11-16" version="1">MTNSAKTLYDKVFENHIVHKDESGSYLLYIDRHLVHEVTSPQAFEGLKNAGRSVRRVDCTLATVDHNIPTTPRTNFKDVETFIEQEDSKLQVQTLEQNVKDFGVTYFGMSDSRQGIVHIVGPEQGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTIIQAKSKNMRIFIDGDLSKGITSKDLILHVIGVIGTAGGTGSVIEFAGLAIENLSMEARMSICNMAIEAGARAGMIKPDETTFEYIKGRPLAPKGEQWDKAVKYWKTLHSDDGAHFDDDIHIKSTDIVPTITWGNSPQDALPITASVPDPTKVSDPIVKSGMERALKYQGLIPNTPLKDIPIDKAFIGSCTNSRIEDLRAAAKVAKGHKKADNVKEVLVVPGSGLIKAQAEREGLDKIFEKAGFKWREAGCSMCLGMNPDILDPEERCASTSNRNFEGRQGARSRTHLMSPAMAAAAAIKGHFTDIREFDYVDVDEPVMTIGENEDKELQAAVYEHEKEQLNNDSESVEEQLYDIPKEPEAKKHKPVAEENPDGANTSNVEAMSKFTTLTGITAPLDKANVDTDAIIPKQFLKTIKRTGLKNGLFYESRFVKDEHGKDVETDFVLNVDPYREADILLVTGDNFGCGSSREHAPWALKDFGIKCMIAPSFGDIFYNNSCKNGLLPIRIPQEDILSKLHPLAKAGKKLTVDLPKQQIRNGETDEVLIEHFEIEEFRKHCLVNGLDDIGLTMQKEEYIQKYEELRRDIYSFLEGGSKLIKPIKGTKKSKFGVKAQEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B607</accession>
    <name>G3B607_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_123505</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B607"/>
    <dbReference type="STRING" id="590646.G3B607"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025144_1_0_1"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF27">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="422" mass="48675" checksum="838416470B30BD0A" modified="2011-11-16" version="1">MFHPIESVTDPENQIPTFKGFTSNANTKIDISKMGKLKPVLPNDAYVSCTVFDQSGNNIAISKRYPKMQFLKDHNLHPRDLRKIDTSLVDVAPQIMIRPPNTILVNLSHIKALIKEEQVMIFDTSSPEIATKLGLFIYDLESKLKAPNNMPFEFKVLETILINVMGYLEAELKVHIQNCGAILSELESQVDRKKLQDLLIRSKGVQSYYQKVLLIKQALETLLDNDEDLAAMYLLKPRTAELKGHTEEIENILESYYSHCDEFVQHSGSLVHDIKATEEIVNIILDANRNSLMLFELKVTIYTLGITFATLVPAFYGMNLKNFIEESQYGFGAVVAFSILQGLFLTMLNLKALNKVQRLTRMGGSSRSKKMGETLNMSRRDVKQEWLYVWMKYMKMKRTHYHYPTMKERFAIWRMMNDNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B672</accession>
    <name>G3B672_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_123607</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B672"/>
    <dbReference type="STRING" id="590646.G3B672"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="174"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV63399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="453" mass="50184" checksum="024C22D06E51B141" modified="2011-11-16" version="1">MDIVAFYQDNNENSDENAFKKFNYDRNFSASSVNNSITPPGTPGAVPNQNSSGSVRNVSTPSQDHRSRSSSVNANTTVPAAYEHQFIPSRPAPRPPPPGSTPSMTSTSTAVTPEQHANVPVSPSSQTSPRGKSLDAKQAALIAQKKREDKKRKNQQILAKLQSICTKGDPNTLYTDLMKVGQGASGGVYIAHEVSNKSSTVAIKQMNLEQQPKKELIINEILVMKGSKHPNIVNFIDSYLYKGDLWVVMEYMEGGSLTEIVTHSVMTEGQIGAVCRETLKGLKFLHSKGVIHRDIKSDNILLNIDGNIKMTDFGFCAQINEINLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMMIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPEALSYDIRKFLSWCLQVDFNKRADADQLLNDKFIVESDDVSSLSPLVKIARMKKASEREDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6E0</accession>
    <name>G3B6E0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114749</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687236.1">
        <property type="nucleotide sequence ID" value="XM_006687173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6E0"/>
    <dbReference type="STRING" id="590646.G3B6E0"/>
    <dbReference type="GeneID" id="18247564"/>
    <dbReference type="KEGG" id="cten:18247564"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_1_1_1"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="110"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="175"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="253" mass="28913" checksum="5F29BD2D3FB3A4EC" modified="2011-11-16" version="1">MAVINQPGTQIKLTNVSMVRMRKGKKRFEIACYQNKVQDWRSRVEKDLDEVLQIPQVFINVSKGQAANNEDLLTGFGTTNQDAIIAEILDKGEIQLNEKERSANLRQKQNEFLNIISTKCINPKSKRRYPPSMIQKALNQLKFHLNPSKSAKLQALEAIKLLVAKQLFPIVRAQMKVKVILVNRVKDQVYDRYIKPMLDAIEDEHQTDKVFEVISIIDPTNYRAIVDVLQGENAKIKRGEGTIEVLDMAVVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6E3</accession>
    <name>G3B6E3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_123725</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3 12"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6E3"/>
    <dbReference type="STRING" id="590646.G3B6E3"/>
    <dbReference type="eggNOG" id="KOG2144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_1"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="391" mass="43513" checksum="E46F47F4B3C31C53" modified="2011-11-16" version="1">MEAKTPQEKYDLITKGLQEVLNADIIKNVLENENRPLKVYWGSAPTGKPHCGYFVPMIKLAHLLKAGCKVTVLLADLHAYLDNMKAPLEVVGHRAKYYEFIVKAILKSIKVPVEQLHFVLGSTYQLKQEYTMDLFRMANIVGSNDAKRAGADVVKQVTNPLLSGLIYPLMQALDEEFLDVDAQFGGVDQRKIFVLAEENLPSLGYKKRGHLMNRMVPGLGQGGKMSASDPNSKIDIIETDKNIKKKIASAYCAPGDVNDNGVISLVENIIQPIQELKAEQWGYFNFPISRPEQYGGDITYTSVEDLKKDFAAEKLSPVDLKAGVTVQLIGLVSPIRDEYEANAEFRDVEAKGYPVAQPKQKKEKKVKNKGSRYPGVGEVAAKLEETKLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6J0</accession>
    <name>G3B6J0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA/RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_135286</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6J0"/>
    <dbReference type="STRING" id="590646.G3B6J0"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_583928_0_0_1"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="10">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="11">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="468" mass="53005" checksum="AB254A56DBDE747D" modified="2011-11-16" version="1">MATLMIRYHPFQQILTFSLKDMCFVEDPEQSVSLCDWDDLITVIGSNVVLDIRREIYSSLEYTTSAGISRNKNTAKLAGGFLKPDNQTIILNSQIPSFMKKFELNDINGMGGKAGDQILRRFNVPPDVNSIEYLNQLPAKDLSVEEYPNLYDIVQGDFSQPLRDRVEIKSMMSRKQMMAKNPIKTVYDSIDWIKTFAGDLCNRLEDLDEESGVLTRPRTVSVNIHIKGSSNSKQCSIPVVKDLKKLEALIIASCMTLIVELLNSMFDLARLNSVEKLDFKNIHPYNKIDIPHIHNIACIISNLAKLENSIDVFTTSDKSSANKKLFEQFEQEQKKNVESQTADPVVQPKMNKVYINKLFQKYEQDQSKEPVTQKKEPSAPNKAPTKTKRPSAAPEKVPISNPSSKKPKYNILDSLKNRTNKSSSPGPTSRDVDPSSSTYYCDICRDSFPDSQEHKDYHFALELSKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7G9</accession>
    <name>G3B7G9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_107500</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7G9"/>
    <dbReference type="eggNOG" id="ENOG502S764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107661_2_1_1"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646">
        <property type="entry name" value="YALI0F00814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17974" checksum="FA411DB022B79F94" modified="2011-11-16" version="1">MNQDSSYSSNNDDTVTVDEVVGASTGFWGLQTVPSQQTNFTAHRRPTRLDLFENNQKLDIRAHQRTYEGAYTRTAIGSLAFSIMIIKLFSKEFLPIGTIYTLYGMVVFIIGVYKSRSVDFYYNPNKGTEYFRTSGTSVIILTAISLVCYLTLFVLIMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Y1</accession>
    <name>G3B7Y1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115144</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Y1"/>
    <dbReference type="HOGENOM" id="CLU_2793752_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="68" mass="7451" checksum="A3C32899803C15AD" modified="2011-11-16" version="1">MARPRGLAIGKSANSGYRPSVSGYDHKHLTIVQTLIPGLFRSSGAYCILAHIQAQQLNNVWALSKLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Z8</accession>
    <name>G3B7Z8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrograde transport protein Dsl1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_135634</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Z8"/>
    <dbReference type="STRING" id="590646.G3B7Z8"/>
    <dbReference type="GeneID" id="18249893"/>
    <dbReference type="KEGG" id="cten:18249893"/>
    <dbReference type="eggNOG" id="ENOG502QR7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023998_0_0_1"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021876">
        <property type="entry name" value="Dsl1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11989">
        <property type="entry name" value="Dsl1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrograde transport protein Dsl1 C-terminal" evidence="2">
        <location>
            <begin position="579"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="690" mass="79832" checksum="BD11DC4F7E44C2E2" modified="2011-11-16" version="1">MIRGLRQQYDERLNHINKKLLDYQKGIDSFAIINDSNFQRPNDSKSTLSELDESLTVLNQNLSHLNELWVIKNLIKEIEAYMADINEVVLSLESLYINFENLLGKLSKLDSNLVVKSEVSTKTAELMDDLWVYLQEIFQKYMPSSDKLKPTIDGVDVGEFLSLVEKFSSISEKIDVNELLAENKVIWESYLLGLAFKKLTLIDTDLHIEDTDGSVLSVLGSILSFIRFINAINVQSLKNLYQPKLSNKLINLISENINILVDSSTNEYITLVEIIKVVEGTHWRLSLNLTLENYDSKMKTIYNNWIMDNYIDKIRQVFKSADFTKVSEIKWEIDGSRFDNMRDQITTMDKRLDVTMSNESKVESKADEQEGGWNSWNDEWDDNEEDPIQPTQEPQEHKGEGWDDWNEWDEDKDSQSIQAPSTQKVSLSALQEQPNPVLNTIRTTIKVSSTANKLVEVLNDFLIESQANLDPLISTILSVSTITYPSSSTSFLLYNDLQYLAKNMDNERINGFAESLINRRMNEVAKTLVQILVKIKQEENNHIILTQLASWFDSIFQTELLNSNFFKFKDIVYYAIDFVCNWVSNLIISIDEVTEYKSQNLTKLIDELNGFFNQKLLLLNETKSLESMERLSNVRFLINNHLVDIIERFYHGDFYNISTGELISVIESCFIKSELRDNYINEIVEFRNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8J2</accession>
    <name>G3B8J2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_108590</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687916.1">
        <property type="nucleotide sequence ID" value="XM_006687853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8J2"/>
    <dbReference type="STRING" id="590646.G3B8J2"/>
    <dbReference type="GeneID" id="18246044"/>
    <dbReference type="KEGG" id="cten:18246044"/>
    <dbReference type="eggNOG" id="KOG3237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061887_0_2_1"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="246" mass="29566" checksum="A1AED71F0589EA54" modified="2011-11-16" version="1">MAKLVHNIQKKQHKERSQTKDRERYGLLEKKKDYRLRAADFHKKQAAIKALRNKASQYNPDEYYHAMTRKRTDDRGIIVSDRGNESLSVDQVKLLKTQDSNYIRTMRLNELNKIDKQKQSLAFKAKGKHTVFVGSKQEQERFSPEEYFNTDKDFLSRRENRPRIEQLESNKKIIESNIDEVVRERLNEKKVKQYKLLKSRMEREQQLKQVESRMEQQKELMKKGNKKKVVDGSGNIHFKWKIQRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9B1</accession>
    <name>G3B9B1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115303</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9B1"/>
    <dbReference type="STRING" id="590646.G3B9B1"/>
    <dbReference type="HOGENOM" id="CLU_1726613_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="152" mass="16970" checksum="D1C9C6119AA9267C" modified="2011-11-16" version="1" fragment="single">MQQQQQQQQQQQRLQQGASNQQMQQRNVQGQPVANLTPQERSQLQMLKAARTQQQQQQQMRMTQQQQQQLAQQIGLNGSPVMANPSANNMNSSKLDYEQRKRMLLQKQQLQQQQYRQRMGQNPPPGANSGTSSTPGSGSGSSSASRSGSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9J8</accession>
    <name>G3B9J8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_125219</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9J8"/>
    <dbReference type="STRING" id="590646.G3B9J8"/>
    <dbReference type="GeneID" id="18249088"/>
    <dbReference type="KEGG" id="cten:18249088"/>
    <dbReference type="eggNOG" id="KOG2760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015433_2_1_1"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031558">
        <property type="entry name" value="Vps36-NZF-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16988">
        <property type="entry name" value="Vps36-NZF-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="613" mass="70693" checksum="FFC8ACFF837F19E7" modified="2011-11-16" version="1">MTSTVPSAAINVWQPVNINRSNRPVLKDDEEIVYIRDNVGLYQGRVKIVNRQSGRVYLTNKRVIYIDNKDIKKSMAVDIDRIYLAATIDGFLRSSPKVKLYVNVEEDSKGGSKSVSLFKSLDWVCKICSFNNHLDSNYNLNNLPRCVSCGIPPQTKYIESLQNREEETSNGLEERRDDQCTKCTFINHPSLRYCEMCGSELKSSIPEDLRAKLHSSSAPDINDEQGSFNRLDIVLEGEESYSGDAKYVKLSFRTGNEQQFYTMLNEILEKRRWEELQSRGGVNQGAVKLNNVEESVRIKESGIYRLQLISEQTRKQNEMTLSSSLEDLEQLMYKAQDLLKLSSSFNSFIKPRVQYNVKLSALTVSKTSKIYHEELARHLSEYLTNYKLVKSSAMITLPDLFADYNRYLILTQGFGMELVTSEDFGTSVECFEKLSLPVVLREYDTGLKIVRPKFNDDYSAIIVNHLKNQEVQFKFNKLKQSILQSFDQSFDQDDYFKTGYKYFKGSTVSEISEHFTWSNDITIEELKKLVEDGLILIDKTISGTFYFINKITNYDFDQEREHDEQLKQEVESQLIKEQAQLEASNWGSLEPIEFQDVEYDSPAMKELKGLKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9Q7</accession>
    <name>G3B9Q7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115403</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9Q7"/>
    <dbReference type="GeneID" id="18247851"/>
    <dbReference type="KEGG" id="cten:18247851"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016485480" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="20"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="360" mass="42456" checksum="FA41A6706A53294F" modified="2011-11-16" version="1">MKLLIILFLFVTPIICSLGDQLPEFMHCNDQCKSYLCLQKRISSISSKYTMGDFDSKNNVHFPFKQLFGWQCPADCDYKCQQIITDIRISQGAPIVKFYGKWPFKRVFGMTEVASVVFSLLNFLINYHNFRKINPQRKRSSGPVRTMYGQYLVLLSISMVGWTFSMLFHTRDLPITETLDYFGASLIILFNFYIIIIRYFELFKNNLLPFQIAIGTIYGLHLVKLSHDWDYNYNLVFHSVIGIITLVLWVLHSVKVSRIYTNNYPILSNSIQLLPFETKILMKLNYLSLSKSKYIPLLPILLNLWMFGSMFFEICEFKPILKVVDSHAMWHLATFFPQIIWYDWNMWDLELYKRVTELSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9V4</accession>
    <name>G3B9V4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTLH/CRA C-terminal to LisH motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_99081</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9V4"/>
    <dbReference type="STRING" id="590646.G3B9V4"/>
    <dbReference type="GeneID" id="18250822"/>
    <dbReference type="KEGG" id="cten:18250822"/>
    <dbReference type="eggNOG" id="KOG2817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041709_0_0_1"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH/CRA C-terminal to LisH motif" evidence="1">
        <location>
            <begin position="184"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="563" mass="65188" checksum="2DD6DEF30D5F6952" modified="2011-11-16" version="1">MSTTLLDNLATESTSFSEAGEKYLSKILDDTHSFVGELKSMEQDLVQQLEQESQGAHPDPVSLESLKNSDLWYKQSIDSLKGYNGQINKFTKHILHNSKYNINLDGAYTYPLNLDNIPVEYLKGPTPGASHDDLTLRDVKMENQKELMKAIVLHLLKIGQSDLIKDMLNDTTKDIRIDEDLLDKFQLLNQIVDGIVLNHDLSKALSWFKQKHESAGPHSNFQEIEFKFHILEYTLLLNRKPNSSTDGGLDSALEAYMYSKQNFPRFFDAYLPEISPLMSLLLFKAQDDVDSSHPDDYARKHMMSLLSDFMIKMKSSFNKDLEQRPSKRNESRFVEEILKHFSSIEQNQNLFQSLSNEFISYYCKDLNLSNDSSLFQSVLSGFINLPSFYKYNQIQRRFSKVRSSSMKEDFDIDTINAIGTSEVLDDPKDKPRPPSIQSKHFNIISPYSFDMPFQLSDSNRFLFDYHPIFICPVTKEQLIPLTVDEVEIELEKKAKRPKLEVSKNDELLKSMHNPVVVLKHCQHVALKESIWQLSKRGSEIFRCHYCYKKHRFSEVTEAYFIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA51</accession>
    <name>G3BA51_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_115474</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA51"/>
    <dbReference type="STRING" id="590646.G3BA51"/>
    <dbReference type="GeneID" id="18247887"/>
    <dbReference type="KEGG" id="cten:18247887"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="59845" checksum="C11F6A1978D69DF4" modified="2011-11-16" version="1">MALNSYQPNSLQIINMSFKEHFSEHSSKWYVAIPAVLVLYLVLSSIQARIFAYKRGCKAPAYAKGGRFGLVLLKNAIKAKNEGTLDRFSEVSLGATMTSKISLGGVVPVILTRDPENIKALLGTQFNDFALGTRHAHFKPLLGDGIFTLDGQGWKDSRSMLRPQFSREQVAHVRSLEPHIQLLRKHIQKFGGKEFDIQEYFFKFTIDTATEFLFGESVDTLKDASIGEVPDIEFAAKHQFADSFNVSQVYLSTRAYSQIFYFLINNKEFRESNSRVHDFTNYFVDKVLESDPEKLSEMSKGGYTFLYELAKQTRDRTVLRDQALNILLAGRDTTAGLLSFTFYELSRNPVVWETLRTAVLQEFGSGTEEDISNISFETLKKCEYLKWVLNEALRLYPSVPNNFRVATKNTTLPKGGGKDESAPIYVGKGTTVAYSIIATHQMEAYYGRDAKVFKPERWATQNKLGWAYLPFNGGPRICLGQQFALTEASYVVVRLCQMFSQISTTDTVYPPKKNIQLTMCLQDGAHISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAL4</accession>
    <name>G3BAL4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114907</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAL4"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="408" mass="45366" checksum="B776F796C4AC2EC8" modified="2011-11-16" version="1">MLTTYSMFNICGTFFKAVVNGSSAAAVVSSRGTPSTFQSAACMCHAMQHKRSLSLFNGARHYFLSRESEDDDLELENPYIQYPVVTRDQMNRVAIDKYKFDFSYASFSFHSTKGESAIHSLSDLSDPTSLNTLLPRRRPHGSPADTLSIKAGDDAMLVSPTVLGVADGVSGWESKGEHCSSGVWSRSMLETLSRLLTEYKIAHYPHNLNKRDIDQIIDDSYLHTSHLMDLQNLNGSSTLVLCMLSGEYLKMISIGDSKLFVIRDGQIVKTNEEQLISELCPKQIGTQTLTQLPSEMAWVDAMKLQENDVILLCSDGITDNLYEDEINKYLNEYLNEQNLGLRQAAQKLLSKAKEIAFDDYAFTPYNEKVNALPKEKFGNKSSCGGKLDDMSICLARVVPNQNGGQVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAM3</accession>
    <name>G3BAM3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_135398</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687611.1">
        <property type="nucleotide sequence ID" value="XM_006687548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAM3"/>
    <dbReference type="GeneID" id="18249871"/>
    <dbReference type="KEGG" id="cten:18249871"/>
    <dbReference type="HOGENOM" id="CLU_1864864_0_0_1"/>
    <dbReference type="OrthoDB" id="4084707at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="165" mass="19220" checksum="46C54EDFE8538C44" modified="2011-11-16" version="1">MDESTKLQVYQKLSRELSKEIDEEALNNMGMFEKIEVVTMLMVKLNFLIIRYSIPFSKMLYVKFTSNQMYVVNNNNFNKLLGLAIRMMSRADSSWSQTTREVSSVSEVYESESEYENDIDDIKYENQINFGPLNLTPIGVWQMYNQGRAGLTTLFNSAEEFARQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAT5</accession>
    <name>G3BAT5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_125639</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAT5"/>
    <dbReference type="GeneID" id="18249116"/>
    <dbReference type="KEGG" id="cten:18249116"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_5_3_1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="69885" checksum="D1F7B90FA3A79482" modified="2011-11-16" version="1">MADNAQHGGDLPVPNTSGSPHPSAPGASYMSYLPNNTFGTLRPATLLRNLLEPEDENEVEEIEHFKYKQVLDRKLTVKSIIGLSFSIMGVPFGMSSTLWITLVDGGNVTMLYGWIIVSFFSLCVILSLAEIISKYPTSGGVYHFSALLSNERYSLISSWYTGWLLLIGSWTYIVSIQFAGAQFILSIFGLKNSYYKEDIMLVLLVYYAMLLFSGFINWKFPKYLEKINRACIIWSLGTTLAIDFLLIFFAKRTHSIKEILTTFDNSRSGWPDPLAFIVGLAGSAYTINGFGLIFSMTDEVKNPERNMPKGVISSLFITFFNGLIFILPVLIILPEMKLLLDETPEIMPIDLIFKFSIESYVVSFLLVMLLIVTVLFQAIGSVTTASRTTYAFARDGGLPYKERWLSVDSVEEDVVPKNAILLSMGISAVLPAIAVISESAFNSFMGSCVMTLTLSNGVPILCLMLNKRRKVKGGAFRLRKVGYIINGLSCFWVVLVCLVMSMPPVIKGLTWSRMNYASVVTVGFLAFATLGYKLWGQKSFEGPKVDTDYFELHNLNAPGRSNLNSANDSFVVIDDEEDNTFEADGRKISYEPPKPVSPSYRGSISSGSNKFEVGDNDDTEVLFDASREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB79</accession>
    <name>G3BB79_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_135458</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB79"/>
    <dbReference type="GeneID" id="18249881"/>
    <dbReference type="KEGG" id="cten:18249881"/>
    <dbReference type="eggNOG" id="ENOG502RDG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031875_1_1_1"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="14"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="460" mass="53324" checksum="EC14383C4448A214" modified="2011-11-16" version="1">MTGFLKVSGTKIVDQTGTPVVLTGAATGGHLNMENFITGYPGHETEHKKVILSKIGQEKFDYFFDKFYEYFWTKEDANVNAKGFERLDRLVDTCAANGIYTILDLHTVPGGQCQQWFSDSPTHFSWFWDFKVFQDAIVHLWSQIAHYYKDNQWVAGYNPLNEPASSDHSKLVRFYERIEKAIRGVDPHHVLFLDGNTYAMDFSQFPDQPFSNSVYAIHDYTLYGFPRGLIGTGFVEPYQGTEAQKAQLQKQYQRKVQYMKQHGIPVWNGEFGPVYASSFRGDVDPEATNRVRYQVLKDQLEVYKHGDPSGDGSAISWSIWLYKDIGLQGLTYVSEDSKWFEVFGKWLQKKKKLGLDAWGNDIDPEYQKLYTRLGEHIKANVPEKYHRVMYPPIMDIDGYVNRVTREMLFSQYCQHEYADLFVGMDFDELDELAASFKLENCARRWELEEVLRGYSEESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB97</accession>
    <name>G3BB97_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_124306</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687695.1">
        <property type="nucleotide sequence ID" value="XM_006687632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB97"/>
    <dbReference type="STRING" id="590646.G3BB97"/>
    <dbReference type="GeneID" id="18249018"/>
    <dbReference type="KEGG" id="cten:18249018"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_8_0_1"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="325" mass="37461" checksum="75C353829A6066CA" modified="2011-11-16" version="1">MPIRLQDDLEGQIASPRLSDDSKSIFTKLLNAIRIYNVPLINFVIMSVLGFFLLKLTTKYTALYMKNSLITIIVTNLVLFGISETLAQSILGYRPAEPLISFKVDYAHNHMLSFNSNDISAGTIFEPYTDEDDNLSSSAITEDQEVERFIDYVQQDNESVISTGDDGFSMRPYYPDMNTNGNRPTSMEQLTYYSFNRLAGFMVWGFVMAFAQCWWYKFLQIYAKDPKFIEVLRKVLTDQFCYSPISLFCFFTYGTMVLESGTWEGTKEKLSKIYLKTLMINYSVWFPVQFVNFLIVPRNFQVPFSSSISVLWNCFLSMRNSANST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBA7</accession>
    <name>G3BBA7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_94424</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBA7"/>
    <dbReference type="STRING" id="590646.G3BBA7"/>
    <dbReference type="GeneID" id="18250397"/>
    <dbReference type="KEGG" id="cten:18250397"/>
    <dbReference type="eggNOG" id="KOG3347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_3_1_1"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="208" mass="23390" checksum="913137FD9D20F709" modified="2011-11-16" version="1">MSRRQLPNIIITGTPGCGKTSHAEALQTRLGKPYKHYSISDLAKSRGLIESYDETLDTSVVKEDELLDSLEPELESGAVIIDWHVCDIFPERLVDLVVVLRTDNSHLYDRMVARGYKDNKIQENLDAEIMEVILQEAQESYNPEIVVVLTSNLEEEKLDNVDRISQWISSWVEDHPTGVTNEFEGSQSDESSEESEGESGDSSDSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBN5</accession>
    <name>G3BBN5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Acetyl-coenzyme-A carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_125826</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BBN5"/>
    <dbReference type="GeneID" id="18249131"/>
    <dbReference type="KEGG" id="cten:18249131"/>
    <dbReference type="eggNOG" id="KOG0368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_5_2_1"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="101"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="260"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="737"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1527"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="1867"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1273"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV62193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="2271" mass="254641" checksum="05CC9BE9CF5EA3C3" modified="2011-11-16" version="1">MAITAPSLHSLTNPFSRLIHPRAAARVFFVHTHLPTYSSLLTFPRSIHLRMSSSATDTSQSNHYTQLHQGLPTHFRGLNSVDTAEASKVTEFVKAHQGHTVISKVLIANNGIAAVKEIRSVRKWAYETFGDERAIQFTVMATPEDLDANAEYIRMADQYVEVPGGTNNNNYANVELIVEIAERTDVHAVWAGWGHASENPILPEMLAASPKKIVFIGPPGNAMRSLGDKISSTIVAQHADVPCIPWSGTGVRDVQIDSETNLVSVSDETYAKGCCVDAEDGLKKAREIGFPVMVKASEGGGGKGIRKVDDEKDFITLYKQAANEIPGSPIFIMQLAGDARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPVTIARKETFHQMENAAVRLGKLVGYVSAGTVEYLYSHSQDKFYFLELNPRLQVEHPTTEMVTGVNLPAAQLQIAMGIPMHRIRDIRTLYGVDPHTSTEIDFEFKNEASLITQRRPVPKGHTTACRITSEDPGEGFKPSGGTLHELNFRSSSNVWGYFSVANQSSIHSFSDSQFGHIFAFGENRSASRKHMVVALKELSIRGDFRTTIEYLIKLLETPDFEHNTITTGWLDELITKKLTAERPDPTIAVVCGAATQAHLQSQSERAEYVSSLERGQVPNKNLLKTIFPVEFIYEGHRYKFTATKSSSESYTLFLNGSRVVVGVKSLSDGGLLIAIGGKSHAVYWKEEAAGTRLSVDGKTCLLELENDPTQLRTPSPGKLVKYLVESGDHVVAGQAYAEVEVMKMCMPLIASDDGVVQVIKQPGSTLNAGDILAILALDDPSKVKHALPFEGTLPDLGLPAIQGTKPIHKFLHDAQILKNILNGFDNQVIMKPTLASIFKVLKDKELPYSEWTLQISALHSRLPPKLDESLSTLIDKSKNRNADFPARQILKQIHKVLNDPETDFSLTEVVKPLTDIAERYANGLVEHEYSFFSGLINEYYQVESLFSGHMAREDDIILKMRDEHRSDLNQVVNIVLSHSRVSSKNNLILAILDEYQPLLQSSSNIANQIRDSLKDVVELDTKGTTKVTLKAREILIQCSLPSIQERSDQLEHILRSSVLQTSYGEIYAKHREPRLDVIQDVVDSKHTVFDVLPQFLVNADEWVAMAAAETYVRRAYRAYSLGPLSYHFHDKLPIIHWKFELPSLDSSHFTAIQQVKTEAPNNMNRTLSVSDLSFTMDPNQKQASRNGILVPCSHLDDADEMISAGLDHLQVGGVSIDLLEKVNYYNVFNVIVHSVEGYDTEEEILAKVNEHLADLKDDLRSASIRRISFVFANKIGIYPKYYTFTAPDYTENKVIRHIEPALAFQLELARLENFDIKPIFTDNRNIHVYEAIGKNAPTDRRYFTRGIIRTGVIRDDVSISEYLISECNRLMSDILDALEIIDTSNSDLNHIFINFSAVFNVLPEEVEAAFGSFLERFGRRLWRLRVTGAEVRIFCTDPATGNSFPLRAIINNVSGYVVKSELYMEVKNAKNEWVFKSIGQPGSMHLRPISTRYPVKESLQPKRYKAHNMGTTYVYDFPELFRQATTAQWKKLTKSTKIPKDVFTFLELIQDDNGNLTAVDRDPGSNKIGMVGFQCTAKTPEYPRGRQFIIVANDITHKIGSFGPEEDEYFNKCTELARELGVPRIYLSANSGARIGIAEELLPYYKVSWNNDSDPSKGFNYLYLSTEDLEALNANGKSDTVVTEKIVIDGETRHVIKSIVGAEDGLGVECLRGSGLIAGATSRAYKDIFTITLVTCRSVGIGAYLVRLGQRAIQIDGQPIILTGAPAINKLLGREVYSSNLQLGGTQIMYNNGVSHLTASDDYAGVLKIMEWISYIPAKRGMPVPILETEDTWDRDVEYFPPKDEVYDVRWMIEGKELENGDFEHGLFDKNSFQETLSGWAKGVVVGRARLGGIPIGVVGVETRTIDNLVPADPANPDSTEVKIQEAGQVWYPNSAFKTAQAINDFNHGENLPLMILANWRGFSGGQKDMYNEVLKFGSYIVDALVDFKQPIFTYIPPNGELRGGSWVVVDPTINADFMEMYADVDSRAGVLEPEGMVGIKYRRDKLLATMERLDAKYADMKAKLKNLPSASDEYTKLSVELVAREKNLLPIYAQISVQFADLHDRSGRMLAKGVIRKELHWREARRFFFWRLRRRLNEEYCLRLLKEQLETDSKLERVARLKSWMPAVDYEDDEAVSTWIEENHSKLTTKVEELKKEKSYNTVRRLLKEDPSNTMNILKDYISSLSDQDKAKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBV9</accession>
    <name>G3BBV9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear fusion protein KAR5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Karyogamy protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_110183</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the KAR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBV9"/>
    <dbReference type="eggNOG" id="ENOG502QVCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1997912_0_0_1"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="118" mass="13534" checksum="31C784ADE55015E7" modified="2011-11-16" version="1" fragment="single">MEELGSYSHINLESYCVKNALREALNNCQKHGVESLDLETKKSSALSLTLCEMGNLRLKPPEVCQNPISVNDCISSLEKVPQYWTLFSGNYREIRKICFEESLPFEKDQILEVYNNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBX1</accession>
    <name>G3BBX1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTEDRAFT_116119</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573</strain>
            <strain evidence="23">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBX1"/>
    <dbReference type="STRING" id="590646.G3BBX1"/>
    <dbReference type="GeneID" id="18248177"/>
    <dbReference type="KEGG" id="cten:18248177"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040829_0_0_1"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF174">
        <property type="entry name" value="GH06923P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="142"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV61010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="388" mass="44140" checksum="BADBC85B23C6D746" modified="2011-11-16" version="1">MPRLEEWEIKKYWEIFQGLNPIDNKLDGTRVSPILKNSRLSDDKLSKIWDLSDIDSDGKLDFEEFCITMRLIYDLVNNNQGSIPEELPGWLTPASKSHLIQANRAVNTGDNNFSSNNSSSNDTEGDEEFLSDDFDWYISPTDRSSYEAIYNSNSDNYGRVRFESLEGLYSSLSKVPRTDISSAWNLVNPKSFETIDKDQVLVFLHILNQREHGKRIPRGVPVSLRATFSKEQPNYDLNAVSITRPQRSNVSSNGPKGFATDYLSKIGQSNVVKDSGTDFSATEGTDWEEVRLRRELANLEDLLERANRETKTDEGVSDELTIVKHEFELLLNYKEEKLQSLQTGKVNSADLTDVRNDIELIESQVNLLQGVLKEKEAELTSLQNQLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC10</accession>
    <name>G3BC10_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_128346</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC10"/>
    <dbReference type="STRING" id="590646.G3BC10"/>
    <dbReference type="GeneID" id="18249298"/>
    <dbReference type="KEGG" id="cten:18249298"/>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_2_2_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="2">
        <location>
            <begin position="27"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="378" mass="42227" checksum="B8D692A9B9A592E6" modified="2011-11-16" version="1">MQMKNALLHVEHERRYLHNKLQELKGNIRVYCRIRPPSPGVHPQQLAEIEYPADDNDVDESLCQAISISKELPSSEYLQGQTQARNKTSYTFKFDKVFGPSHQNSQVFDELSQLVQSALDGFNVCVFAYGQTGSGKTWTMSHPGDGMIPLTIHKIFDDISDLKQNGWEYSVEGQFLEIYNETIIDLLANGSGDTKYDIKHDDINGKTTISNLRTIRLNSAQEALMLFNKSALNRSTASTNSNERSSRSHSIFVLNIKGFNAKIGTSCEGCLNLVDLAGSERLNNSQAKGDRLKETQYINKSLSCLGDVIYSLGQPKNNHVPYRNSKLTYLLKHSLGGNSKTLMFVNISPAATNFNESLNSFRFATKVGNTKRGSGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC47</accession>
    <name>G3BC47_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_128404</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC47"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="564" mass="61727" checksum="1716F9F509134B7F" modified="2011-11-16" version="1">MTEHTNLTFKDQIKGFPLVQILVISFIKLAEPIAFTSIFPYAFYMIRDFGVAKSEAEISTYAGYLAAVFAFGQFTSAIVWGKFADVYGRKIVLILGLLGSSFSILLLGFSSNFWMAFLARGLSGLLNGNSGVSRSVIGEIAPHKHHQGLAFLSMPVAWNIGGVFGPLIGGTLSHPFRPDTPPSSAWGRLNWDYPYALPNMVIAAILIVEALITYFCLKETHPTLQYHDDPGINRTKRLLRGLGLIGQELGEIEVVEDEETLLLVKSKSSETVNVLEDGVPTADYGINASTSFLRGLGIGSVQSQSEFVEDAEDENTIFLVKSAESGQSADLETDLEPFEWRSILTPKVLNPILAYFIMQSHFTAFDEFLPIFVSYPPAYTDTGARVSQFPLHLKGGLGYTPKRAGDLLSSSGFFGMFMVLLVFPTIDRKFNRNTVFLVALGIFPLLFAILPYVLLFLPQQLDGDLTTKYADQFLYAFVFIRVMVASSLMTLAMVSINSNAKKEYRGIVNGAAISAASLAACISPLFTGRLMTVGQACNVAGLGWWGLGIITTLGFIQGCFIRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC49</accession>
    <name>G3BC49_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_137258</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC49"/>
    <dbReference type="GeneID" id="18250047"/>
    <dbReference type="KEGG" id="cten:18250047"/>
    <dbReference type="eggNOG" id="ENOG502RQI5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482369_0_0_1"/>
    <dbReference type="OrthoDB" id="1747213at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="58160" checksum="6222353101162C0D" modified="2011-11-16" version="1">MYNLFQEKLKQVFSSSKGTFTLNLHKWSHTSEYIFSHVQYMDEKFDTFELPLGLVNLELVDGNVDVALVKNAFLQELKGKISFVTTNFELDPKAKSIVSFLMGNGDSIENDLDLAICVNCDDRVLQCFPSFVLESYHCFLKELASPLELEKLMGTAVLFSQKVEFMFQLVIQENAPKALSLDSYNFKPPKDIDDIYKTHLKDTNSSNIIFRTRALVNMKKYLVDPNQFTPYQWQLLEFLSYISVFTYKLVCDHTRTPSSHQLLQHLKYELFLFNQMFEMFPSKFNLLSRGIYKVFEEYFIKVEAYHKSLQTKADILMATYLSPDSRRFLQASDVQSIRTEVFKNRYPISTIDSTFGEDESLGVVDGFVMEAFQCSGSLSPECFSFESFPSGRCPTRDLVGFWKKNHLDFPTLAAVARRVLPIQTGTGRGLGEFKANFDRILTSVQQSQLCSIESFYFVYCLSREIDLICASSGDTRIEQFQHSCHKPTIVHKSSISARDLHLPQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCE7</accession>
    <name>G3BCE7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116883</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCE7"/>
    <dbReference type="HOGENOM" id="CLU_1855009_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="138" mass="16268" checksum="8F78B4719231AA05" modified="2011-11-16" version="1" fragment="single">MPEGCCNMPNRAFRIRENLTRQQRKTRHLQGKKEVKQTEKRVYATWFYSKRRISQMAVRRVQEYVASNMVTELNRQARAQDRSIIISPVSGATSVQIEETHNVREDSCHEDFGVHQPWHSSAQTFSLRKDRLKPQPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCM9</accession>
    <name>G3BCM9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_111013</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BCM9"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_3_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
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        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
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        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="ABC_transporter_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
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        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="938"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="980"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1066"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1168"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="278"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="607"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="943"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1260"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV60205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1522" mass="171281" checksum="D941506F9B322EC3" modified="2011-11-16" version="1">MALEASAPAPELASYSFYQCADRGGWYLLDPQYYDLSPCVVQGLLMGILGVGSLLAGLHQVSVLYRKKITSANRVSPFFYVKLGLVLIQIIFQLNIRSNYPKNDLIGTVLNVNLASTIVVLAIHYLENFKVTIPNAVVLFYWFFTVVLNLFKILNLYVRSKIHTNSGVFTILMVVNAFLILVIELLVPIKSLVPLKDAKRISPYDRANIFSKITFVWMGELIQRGYYKFLTEKDLPPLPKELKATTNSDIFYKNWYCQNTPNPSILIALVKSFGAHFAMGSVFKFTQDCLAFVQPQLLRLLIQFVNDYSQAQKTDQPLPLTKGFMIAGGMFLVSVIQTSFLHQYFQVVFDVGMKIKSSLVSVIYNKSMVLSSETKQESNTGDIVNLMSVDVQRLQETVSYLQIGWSGPFQIFLCLFSLHGLVGNAMWAGVAIMVVMIPFNSKLATYQKALQKTQMKHKDARSRLTSEILNNIKSLKLYGWEEAYLEKLNYIRNEKELKNLQRIGVFMSITVMIWNFAPVLVSCCTFALYIVIEKDKPLSTDIVFPALALFNLLGFPLAVVPQVISNVTESQVALGRLHKFLHGSELQPDAIIRLPKVEEIGQVAVSIEKGNFLWSKPKDDKNNKVALSNINLSAKKGHLDCIVGKVGSGKSSIIQAILGDLYKLQGEVKVHGSIAYVAQVPWIMNGSIKENILFGHRYDPEFYQHVLKACALTVDLKILSKGDETLVGEKGISLSGGQKARVSLARAVYARSDVYLIDDALSAVDEHVGKHLIDHVLGPKGLLKSKCKILATNNIGVLSIADNMHMVADGKIVENGSYDEIQSAPDSKLFHLIKDFGKAKEQPSEEELNEEAEKQKSKSQELLVDDEVTDIQLESEDELDVQSLSGASLVTLDESLEDELDAKEEDDEELAKRKEHFEQGKVKWDVYLQYAKACNPKVVCIWIGVIVFNMWLNVASSLWLKYWSEVNTGAGYNPDVPFYLGIYLLLGFINSLSILAQNCIVWIYCTIKGSSKLHNLMAIAVLRAPMSFFETTPIGRVLNRFSSDVYKVDEVLCRVFGMFFSNSFKAVFSIMVICFSTWQFIFLVGPLVVFYVMYQQYYLRSSRELRRLDSISRSPIYANFQESLTGVNTIRAYNEIDRFRYINELRIDKNMRAYHPSVNSNRWLAVRLEFFGSIIILGAAGFAIFALKSGSISAGLVGLSVSYSLQITQTLNWIVRMTVEVETNIVSVERILEYSRLDSEAPEVIEEKKPGANWPQSGQIEFNNYSTRYRPDLDLVLKNINLSIKSHEKVGIVGRTGAGKSSLTLALFRIIEAAEGNITIDEINTSVIGLKDLRQRLSIIPQDSQVFEGSIRSNLDPFAKFSDDAVWRALELSHLKDHVLKMFEEYREQRDSEEEVKDEEEIIDPLEVKLTEGGSNLSVGQRQLMCLARALLIPSHILVLDEATAAVDVETDKVLQQTIRAEFKDRTILTIAHRINTILDSDKIIVLEKGEVAEFDSPENLLKKKDSLFYSLCKQGGFVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCU0</accession>
    <name>G3BCU0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_136699</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCU0"/>
    <dbReference type="STRING" id="590646.G3BCU0"/>
    <dbReference type="GeneID" id="18249992"/>
    <dbReference type="KEGG" id="cten:18249992"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003731_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000004">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="20">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="18">
        <location>
            <begin position="538"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="19">
        <location>
            <begin position="1110"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="377"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="705"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="770"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1004"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="836"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1008"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1060"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1079"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV60209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1256" mass="138235" checksum="35A4BE19D67F187E" modified="2011-11-16" version="1">MRKLKVGIRTQLIVLVTFACLFSLLILAVVCGVYFSNNLSDLRAERLEVISQLKTSQVTQALDYLLYQIYWLTTRDAITTPLSSYKAGNNSNTVFDQAQDTLDQFVTSSESFAAARLYNLDLTVVAESTNNASSVSQPSMDYLYPLQANLSVPSQINSLSNQVQSFFMTGPVSNNSDADSTYFVGLTYAVYANTSIILSTPAIAGYLSVIANANNIQQAVNDSESSNDYTVLALAPVFDSDSSTNNTVDDIIGFQAVFPVAGSSLNSDTVYNINSSSAAKAALLHDSGASTKQKNIDGKSVAIGYSTLDLDSPKYWSIIVEQRISTFDAPVRKFTKIIIGVSIGIGGFVCLITFPMTVFFIRPITNLKYATEAITRSKRERERGVEKPESSGSTGNTNSPPPPYYSTLIRRFNNKDKEEEREHLIKEKEKEKSGPNGSAKGSSNGSNNKRNSVLSAGTGGSNSVYSTGIRLPSRIPDSKKIFKDELSELTQAFNIMREELEKQYTHLEDRVKSRTKELEASKIEAEAANEAKTVFIANISHELRTPLNGILGMTSIAMDEEDTSKIKDSLKLINRSGELLLHILTELLTYSKNTLNRSKLEKSSFQILEIAYQVQSIFSKLASDQRVFFKILMKPSLMRKLILYGDSNRIIQVVMNLVSNSLKFTPVDGKVNVTFRLLGEYDQERSNQSDYNQVYVVGHETAANTLSKSNPYDGRPPKMPPTTNEAAFEQSSASSVDADGDDNDTTSIVTLSTTQYQDAVFKSQFKRDMKPLPTVPADSSDTESNFDTDRKLSSSESDDTAPTLPSKDNVLVTSNGHATVSPKLLPPPNMRDKFISTASTSGTGTTTKRPSISSINSSLNSNELVKNDKVYRIKNFYKPKTWVLQIEVTDTGPGIEPALQEKVFEPFIQGDQTLSRSYGGTGLGLSICRQLAKMMNGTMTLKSTLGVGSTFIFTVPLPQVGEVLVPEEDMAEFCEDEFNPKSKMNRKVAFTFNHEDIINEVSEAEDTGYSNEANASSRSELHSTGTPLSTSSPKDSVGPLDLSKINPPNITIELPSPGRKSSEESASKKHYFEKPHLIARSSTGTANSSNGSDKMDLHNNYLLHDLLHLKILVAEDNLVNQEVIRRMLSLEGFTNITMASNGAEAVDNVKESIEKNDVYDLIFMDVQMPKIDGLLATKMIRSNLHYDKPIIALTAFADESNAKECLNSGMSGFLAKPIRRTNLRKIITEFSPILLSETVTTPQTHQSDERRLGYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD35</accession>
    <name>G3BD35_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_137374</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690123.1">
        <property type="nucleotide sequence ID" value="XM_006690060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD35"/>
    <dbReference type="STRING" id="590646.G3BD35"/>
    <dbReference type="GeneID" id="18250064"/>
    <dbReference type="KEGG" id="cten:18250064"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="OrthoDB" id="4025884at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="500" mass="56420" checksum="190E9D67B5AD9A92" modified="2011-11-16" version="1">MAYSREAKILVVGSGVFGLSSALNLVQNGYKNIEIFDRINHDKTKYNPLNGSDCASGDINKLFRIYYENKTLYSKLAISALDVWEQWNKDIQKLSEEDKSRFIDDDLELVRMSGAMRLNSTSALSAVELTNLEGFNELGLRDLQYNINSKKDTQRAKLVGLSAKLDVIDDWKQRKKVTTISGTLDGVGRMLKADKACFYVKILLEQQGVKFHYDDAGTFISPITDGCEIKGIKTKDGKSHFADLVIVSAGPWSTSLVPALEHHARASLANIVYLEIPKSRQDLINKYSEYPHIQWKTTSSEFDRNKNHSDGEGGFAFFPPTKKEGILKVNTRQLKYWNPVKVDGKYVSVPKTLGDEKLPKSVIQEAKDILMAIAPDVVSLTGIKVTSKLLWYTDAINSDFVIDFVPGYKNLIVATGGSSHGFKFLPVLGRTVVDRINGVSNDYTELFRWKSTDDIVQDNYGLKQDVEKQDYRKFDNAEFLEQQDLIYTEEDLKRLESVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD41</accession>
    <name>G3BD41_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_116958</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690515.1">
        <property type="nucleotide sequence ID" value="XM_006690452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD41"/>
    <dbReference type="STRING" id="590646.G3BD41"/>
    <dbReference type="GeneID" id="18248521"/>
    <dbReference type="KEGG" id="cten:18248521"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="332" mass="36680" checksum="72E4A52F2627E8C7" modified="2011-11-16" version="1">MSKVFITGVNGYIAQHLLAQLLEKGYSVVGTVRSEEKGQELKKSFPPLEYEVVPDIAEPGAFDKALQKHHDIVGFFHNASPLILESDDIENVIIVPAIAGTLNALEAVKKYAPLVKRFVFTSSNAAIVSPTDGKDSVVTEESWCNLGRNDGATGLMGYKISKTFAERAVWDFVEKEKPNFTFNVVHPTFVFGPQAVASNAKLPLNHSANFVGKLIKLNSDDPLPPSAGAFIDVRDVAKAHIFAFETELTKLRLYMYDVKFNTQRLVDIIRANFPQLSYLPKGDASKVAEYGNLPQIQNEKTRSLVGPFISLKQSVIDTIQQLIDQHPEYVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD95</accession>
    <name>G3BD95_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_109984</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD95"/>
    <dbReference type="GeneID" id="18246162"/>
    <dbReference type="KEGG" id="cten:18246162"/>
    <dbReference type="eggNOG" id="ENOG502RY5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035993_0_0_1"/>
    <dbReference type="OrthoDB" id="4024574at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442811" evidence="1">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="413" mass="47196" checksum="A89513E22BDC8AB9" modified="2011-11-16" version="1">MLLFRFLFAWLSFVGFGVSDKICGGSTLIPFSGFKIVRQYKLSISGMKPSSQQFISLVHCSAGKADYQKTIKVDSITQIDWKKPFCIYKPRLGSYNPDHPHDTVRNLAAKMMPGGLNTSMETQTSASTTGTVFGYLRDKFDKILERVTGNNKIVQYTGERTNRHIQDIEGATLQASMEWESRNLVCYKLARRRKYSKLDLSFYVPSTFVGGLFECGVSPEQKRKMFQEFKMPNTVRSFDVECEPEISRPLMPLIADYSTNQWWDVSKNIFSPSAFQNIPYLTTSDRFDLRFSVYGSPDTSSANWASKIRVNEDYDYSGLDPHLFSEVVASTSDFIFKALKPIDFTTLIKQNEELTNYKIAGKPIAESDLIINALKKLNLDQKMGILLSLQPSKFLEILQRLQNKWDSLFKHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDH4</accession>
    <name>G3BDH4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nonsense-mediated mRNA decay factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_136783</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDH4"/>
    <dbReference type="STRING" id="590646.G3BDH4"/>
    <dbReference type="eggNOG" id="KOG2162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015710_0_0_1"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="83"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="249"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="834"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="853"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="883" mass="101287" checksum="771D8193258F27A5" modified="2011-11-16" version="1">MSVKTSPVQDVTYDSTALNQIKHFKLQLTNLLNQSFTDPALLLGLNSVILPKFTDWTTKDFDNYYKLLEVDCVSNQVEFNTIKFLDTLWMNFHYPIIKFFKLKHKEMSPIDSQALSKNDPPKLRTVEIRKINDFFIKFTKTTYGFYSDILQYFSTNFQNPLLPSSFLKHFNYELNNRARETHSPTLQANLLYVMHKCLLCLGDLLRHRSFIETNYVLPNISIKNYFQFKSKTGFATGKLLEYYHPSSVMYNLCIQLLPALNEPYNHLGMIHNMSNDKMTAIYWFLRANFTRLSGYKLGLTNLNNLLVQPWVKLDLSNLLRARSPNHGSITNDQLNLMLTSIICYHYLPEKYRLPGNRILGNLKVGKLEFIFLSLNFNENVFQRSQKFTCGVPLEDFYLFQLTLLICFTRLMNTPSFSKFVNMYLEFYLKSLNEPKESTITKNSSALMCIRLLLNWLSSQNKRFLSLSNVKLLGEVMNKMVGDYTVDDLTTKPIRNYYFAEDIMFKDFKLVSHQLKDFNDNHLFEANNIDLLNNNFSSLVVDGVPIFLDNTFIKENQFKSDDAFIQSEVQKYENTSRVLAVLSQFYDLFQDKFTFNGNFVMKKYERKIKIMQQKPHGSIHRNKHPEPQELDQSHGEIIISSIEGHTKPPVNHDSSGSEEENGHAIQNVIDDESQHEESDNDMMPDTSIDEIEEFIRHHTTQLQSQMQQEEILTSTSNPAPPSTRGNSDSWEAEVAATPVTSQTSTQENYSTANSGTQSPATSFPIGAMSMAPGSAMHTFANMAPPNMVPYSGTGLLVPGPNLIPYAYPSAVPAQPGMPPVQAQYWQFHYSQPPPFPGQFPPPKMGMNPNQQPIFQPPFPPNSQFPPPDQSYPPNANFDSGWHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDI3</accession>
    <name>G3BDI3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leo1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_109977</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDI3"/>
    <dbReference type="STRING" id="590646.G3BDI3"/>
    <dbReference type="eggNOG" id="KOG2428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052544_0_0_1"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="367" mass="42746" checksum="B8809FD2A4972F7E" modified="2011-11-16" version="1">MSEEELNSKRGLSNEEDKEDDLGLGLDSDSDTSLKSGQDNDGSDNNSEDESEEEKELKTFDLSVPRHAITSKPEDDVYHLKMPLFVNVDAHPFDPVDFKENIELNARNRDINIKDSKLKKNDLIREKLTNENTIRWKYSNENDEIIKQSNCHFVEWDDGSLSLKIGNEMFDFKSLPLYDNILVRSHDDLEILQASTILTKTSNLLPTSTGTSTHKQLANAIKFLQQKDKILNTITDSDPLEVQRNADENERKALKMKRQLELKRRLQEERLGRASPSLEKESYEEPSYERFNRTYNDEYDDEDDFIDNDEDDEEIEENEEDELDQAAERLRQVKEAGKSKYEKAGEAEDVNELRRKRRRIIDSDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDM4</accession>
    <name>G3BDM4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_116388</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689553.1">
        <property type="nucleotide sequence ID" value="XM_006689490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDM4"/>
    <dbReference type="STRING" id="590646.G3BDM4"/>
    <dbReference type="GeneID" id="18248279"/>
    <dbReference type="KEGG" id="cten:18248279"/>
    <dbReference type="eggNOG" id="ENOG502SCR7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1510398_0_0_1"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="178" mass="20245" checksum="E32872F6FFAF6F4A" modified="2011-11-16" version="1">MSVTEGEGIIPSYITELTSNPVIRIRNIHPELTEDDLSGLLSQISPVEFVKFDADKKSVAYCGFQENWSENNAESIKKFDGRKAMGKILIVEDPLKPKTVKSLQDRLGPLPGARERGFRGPKRRDNRGPRGPRDSRDFRDPGDIRQKQRGRREPPKPKKVPKSVEDLDRELSEYMNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDN7</accession>
    <name>G3BDN7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_110574</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689560.1">
        <property type="nucleotide sequence ID" value="XM_006689497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDN7"/>
    <dbReference type="STRING" id="590646.G3BDN7"/>
    <dbReference type="GeneID" id="18246206"/>
    <dbReference type="KEGG" id="cten:18246206"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_1_2_1"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="41"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="281" mass="32548" checksum="601C06E3BE284143" modified="2011-11-16" version="1">MATYSKKDFNTKHYNDARPSYPPAFYETLMDYHGSSRDLAVDIGCGSGFVTFALTKYFKKVIGTDISEVMVEQCRADPRTQKSDKLEFYVGAAEETPSVIKENSVDLLTGAECCHWVDHPVFFKESWRILKPGGTLAFWFYKDPIFVDFPAANDIYDEFCYESPEYMGPQYEQPGRALLRTLMKEIDVPEDLYTDITRVEYEPLRDKTPNTLYIAKRINLAIFKEYVTSWSAYHNWMKAYPDKKDVADQFIDKLASTLGWDDDFEFTVVWATVYTFAKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDU5</accession>
    <name>G3BDU5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116437</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689597.1">
        <property type="nucleotide sequence ID" value="XM_006689534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDU5"/>
    <dbReference type="GeneID" id="18248304"/>
    <dbReference type="KEGG" id="cten:18248304"/>
    <dbReference type="HOGENOM" id="CLU_1731226_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="151" mass="14276" checksum="F71C322FB77646F8" modified="2011-11-16" version="1">MSDALSLYSSIADGASSVAGATSNFGSSLHAGSHASAHVSSVGAEASSDVESLIDSISKGGSITDDFSSASKAASKALASLSEDASDLGSGSAVAETSLEVSDSASSKTAGSKSKSSSGSSTSGSETSGGFGATVQAPVFGSLAVIALALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDW8</accession>
    <name>G3BDW8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_132176</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDW8"/>
    <dbReference type="GeneID" id="18249599"/>
    <dbReference type="KEGG" id="cten:18249599"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="28"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="477" mass="53345" checksum="D4FD673828FA98F0" modified="2011-11-16" version="1">MKYADITKDMVLTPEAEKRILRKVDMIVLPFMTVMYGVQFMDRSTLGYSAIMGVKDIGPMVGTMYSWLTTGFYIAYLAWAFPGSWTLQKFPLVKTLCAYIFLWGFVLAMHAAVFTYPAIMVCRLFLGIFEAPLLTGLSLMGNNFYRKDEQFKRMAFIYAGTGFGNILGSVVAYGIEKDATNWVLTSWRSLFLILGVVTMVLAVAMVLVVPDLPTQAWWLSEEDKLLTVERIRDNEQGFGTKDFKWHQVKEAFLEPRAYLFAMLAICIELPNSGITAYGSILLNTEFEFDTEKALLMKAPTGVVQLFGLSLIGILNSKRLIKHPTIVALIGLCFALMGGCMLCFSKNKYAALAGFYLIGFSPISMVTALTGLSADIAGRTKKVVCNGIYLVGFCFSSAVGPQTFLASEAPNYPTAKYCLVGFYIGAMFTIAILGYYNYSVNKKRDSERDALGDAYKKVENSAFIDMTDRENKDFRYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE20</accession>
    <name>G3BE20_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="6">6.3.3.1</ecNumber>
            <ecNumber evidence="7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CANTEDRAFT_116475</name>
    </gene>
    <organism evidence="27">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="6"/>
    <dbReference type="EC" id="6.3.4.13" evidence="7"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE20"/>
    <dbReference type="STRING" id="590646.G3BE20"/>
    <dbReference type="eggNOG" id="KOG0237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005361_1_0_1"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000011">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="25">
        <location>
            <begin position="117"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EGV60437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="791" mass="84512" checksum="CAC9E832247A0E81" modified="2011-11-16" version="1">MSSTQLNILVIGNGAREHAIVWKLAQSKSVSKIYVAPGNGGTQVSDKVVNVPELSGSPKCFEALAKFSLEHQINLAIPGPEQPLVDGISTVFTKIGVPVFGPSEKAAVMEGSKAFSKVFMDKHNIPTARFKNFTSVEDAKKHIQEIDYNIVLKADGLAAGKGVLIPETKQEALQGLDEIMVAKNFGSAGDEIVIEEYLEGDELSILTITDGYSFFNLPAAQDHKRIGDGDKGLNTGGMGAYAPAPIATPEVLAKIDSKIIKPTIDGMRQDGYPMCGVLFTGIMLSPTKEPKVLEYNVRFGDPETQTVLPLLTEDTDLAQVFLACAEHRLDSAKIELKPNTFSTTIVMSAAGYPESYPKGDEITVKTPLPADTYVFHAGTAEKNGKIVTAGGRVIGSTATGSTVKEAVEKAYAGVEYVKFEGKYNRTDIAHRAFRDAEVASKKAGVTYEESGVSVDKGNLLVEKIKAKVKSTARPGADSDIGGFGGLFDLAQAGYKTADTLLVGATDGVGTKLRVAQIMDIHDTVGIDLVAMNVNDLVVQGAEPLMFLDYFATAKLDIKVAADFVSGVADGCIQAGCALVGGETSEMPGMYAPAIMIPTKDKVLPFVEKMQAGNVIIGLKANGLHSNGYSLIRHLIESSTDYDYTSPAPFSTTGKTLGEEILTPTKIYVKQVLAVIKEDLTLGLANITGGGLVENIPRCLPKHLQAVLDINTWEVPEIFKWFGQLGNIPYADILKTLNLGIGIVLVVEKHNVEEAKRILVQQGEEPIEIGVLVEKSNADDAGCIVNNIDGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE78</accession>
    <name>G3BE78_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116531</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689692.1">
        <property type="nucleotide sequence ID" value="XM_006689629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE78"/>
    <dbReference type="GeneID" id="18248347"/>
    <dbReference type="KEGG" id="cten:18248347"/>
    <dbReference type="eggNOG" id="ENOG502SDX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598510_0_0_1"/>
    <dbReference type="OrthoDB" id="3162794at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="457" mass="52839" checksum="2DCEF4EB224FEF9B" modified="2011-11-16" version="1">MIEDFPSEVVELVLQSSCQNALVNLAATNSRFNRLVKPHLFKSIEVNSQKRILSEKPEAVRFHAVQVTSIYNLKVLMKNLVSNETNCHLIQKLIFKQLPDLPEDFLINYFFHIFPRLVNLAEFKWYSTYNLDLTIVNLLPNIKLSKLNGNFKNFNNFNYDFRNLESLSLSGFKDFSNVSINLSTFINLKFLKISKKNLILYEDNLDNLFTNTSCLDLFALCLENLFLTKRDIELLVDKISFSGLKTLKLINCYELLNGQNSLLTSINESGASLQYLELDIWNNELNNEQVYKFLTSHRQLASVKINLNISENLIKQLTTLISQLNPVCLKHLEITFTIRSHNKINFLNHTDQKEILELLNSFKNLSTLKFPIFSANLGDLTFDLPCLDALQLNLIDYFKFKNCLIDLDITQLSVTGFNSLMKTLNCPKLQYIIIKLFEFHIYDVNTKVVSSLPKLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEP4</accession>
    <name>G3BEP4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115972</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690170.1">
        <property type="nucleotide sequence ID" value="XM_006690107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEP4"/>
    <dbReference type="STRING" id="590646.G3BEP4"/>
    <dbReference type="GeneID" id="18248103"/>
    <dbReference type="KEGG" id="cten:18248103"/>
    <dbReference type="eggNOG" id="ENOG502S8MB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132731_0_0_1"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="150" mass="17245" checksum="906D343F8E96A00D" modified="2011-11-16" version="1">MNTKLFTRSISQLTKQIYLHPSYKISFGKAENSLAIGSFATPDLTREAFVPNPQFLPKLNQLIGERVHEDFTFIMEASVNANSFMPIYDLRDVPRYGRIPEIDSVFGYLQVSDKGEMLKGTYQNNDMYQLYNSTGLIMLSDFLLEEVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF61</accession>
    <name>G3BF61_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_137126</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF61"/>
    <dbReference type="STRING" id="590646.G3BF61"/>
    <dbReference type="GeneID" id="18250039"/>
    <dbReference type="KEGG" id="cten:18250039"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015387_0_0_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="89719" checksum="A7522FC2EA2D68C6" modified="2011-11-16" version="1">MDKTFNLRHNRKTVFYGLIVVWLVSVNLWLYGYKSVGFAASEASIYDHEYGTPTTISAQPSSVNVDVFHDTTIKNMAQAVGIKDTRSIDAHSSVYDSLLAKHQLSDILTNLDFTERCDLYFKNLFGQNRNWFVNPSEDLPLDHRHEFDYESFKHNVYDGMKEKYAEGSHKKVDDVDYNDKKVAKAVESLVKAEYKQFWDKTMGIEQKMVDYLSHLRIFNKCYITNDNKYIMDKANKLLTKEATKIDHSKFQADSAEKLINHKSFGSCSELESRIYKWISFSYPIYERWTGDIFLTPPNMRDFVKYPEVFKPTTPKFNELTDDVTKSTLTGNKPCFFNNFKNKLNGKGIVLSIKDSHVDDTVKLIHLLRALNNHYPIQIVFYDSINDESKIKIVNAARKKMIDLPASFNKVAKNFPPGYFNFQDGGLPKQEVWFVNTYNAIHNNYKDKFRGFANKFLATLFNSFEEVMLIDADTVLVQNPSYYFNLKNYVSKGAYFFKDRTAPEFRPTGDTKFFEKITPSILDNLMFDIPIISQKTLGLEFFQGMGHFMESGLVLINRNLHFNSVLTMVQLNFFNPVTTRVYGDKEIFWLGFATTGDEDYHFNKFFAASVGALTPQQDRLNGDGTEKKSQEVCSAHPGHINGEDGKTLIWFNSGFKFCGQSDVVKYEDEVKKQEHLKFLKDAQSMREYYEGPIVLKNAIIPPFKNKLETWAENIIEEPRQGWHMEKGYCNSYLWCAYSSIGGLTNDGGDTTQTGQVFDFDKDSIDLFKYYGDVWVGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF78</accession>
    <name>G3BF78_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_110363</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF78"/>
    <dbReference type="GeneID" id="18246188"/>
    <dbReference type="KEGG" id="cten:18246188"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001765">
        <property type="term" value="P:membrane raft assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="469" mass="50940" checksum="9C0EF5A423674CC1" modified="2011-11-16" version="1">MATATITTHTTIPYSVFSPKQKYVLMVILSMAGFWSTVSSTIYFPAIPTVSSYFNISSGIANLSVVAYLFFQGIVPTFSSNAADTVGRRPMILLSLLIYVAACIGLARSNAYWLLTVLRCVQAAGIGPVISISSGIAGDVCTAAERGGFVGMVGGMQLTGNAFGGLLGSGLISSYGWRGIFVFCAIGSGVTLVVISLVLPETLRQMVGNGSIKPQSVVNIPPIFVFKRLRRGWTNQIESLGPRKNLDVLAPFKILFNYQTLCVLFAPAVKFAVWSMALTSLTVLEGDGYNYTVLKVGYIYLPQGVTCLLGSLITGRLLNWSYRRSKNLHDEKYKEVPEHERPVFNSLRSRLYVCFVPSVMQFTGMIIYGWCLQFKMNISSIIISTCLISFSSSAAISTVSTVLVDMNPHHASAGVSLINLTRCWMAALCMGVLSNMTAAMGLGGTYTFWAAVGLLADTLMFYVAWYKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFA0</accession>
    <name>G3BFA0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116028</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690194.1">
        <property type="nucleotide sequence ID" value="XM_006690131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFA0"/>
    <dbReference type="STRING" id="590646.G3BFA0"/>
    <dbReference type="GeneID" id="18248133"/>
    <dbReference type="KEGG" id="cten:18248133"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_15_2_1"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="95"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="239" mass="26906" checksum="34F61B7B236C885F" modified="2011-11-16" version="1">MSETKVILHWLNHSRANRVLWLLELLDVNYEVKVYKRNSKFRAPKELEAIHPLGKSPVIEVIKPGKQPEVIAETGCIIEYLINNFDHSEKLVPSTDKGKAEVNYYLHYTEGTLQAVLTSFMVLYSARNFAPFGIGALVGAVTSQVNKAYFGTEVIKNLNYLENIAKGHDGGYFVDGKLTGADVILSFPIAELVMGNQRDGLFEKSPQELFPYLNKWSKLVLADPAYKRAIETIDEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFQ1</accession>
    <name>G3BFQ1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_111568</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 13"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFQ1"/>
    <dbReference type="STRING" id="590646.G3BFQ1"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="351"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV60076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="386" mass="44124" checksum="E160EFB763B3ECF0" modified="2011-11-16" version="1">MSTDGEFTRVQIFGTVFEITNRYTDLNPVGMGAFGLVCSAVDKLTGQNVAVKKIMKPFSTSVLAKRTYRELKLLKHLTHENLITLDDIFLSPLEDIYFVSELQGTDLHRLLSSRPLEKQFIQYFTYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDLQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWSVGCILSEMIEGKPLFPGKDHVHQFSIITELLGSPPPDVIDTICSENTLRFVQSLPHREPISFSERFAHCNHVEPEAIDLLARMLIFDPKKRISAADALSHSYMEPYHDPTDEPVCQSKFDWSFNDADLPVDTWRVMMYSEILDFHQIVGDNGQAPQPDELAQLQHEGIQAPSNGQSQSHEQRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFS0</accession>
    <name>G3BFS0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_128247</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690548.1">
        <property type="nucleotide sequence ID" value="XM_006690485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFS0"/>
    <dbReference type="STRING" id="590646.G3BFS0"/>
    <dbReference type="GeneID" id="18249292"/>
    <dbReference type="KEGG" id="cten:18249292"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="217"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="621" mass="69243" checksum="3EAE4EBA3A28737B" modified="2011-11-16" version="1">MSFDTQIFCRQPRTVGLINKYSDVESFPKPAAECRSAVYSANGKYFGYTQPTEVVVFSTETNKVLLKIELSDVFDIAFSPNGTYLCMWRKPVMLNKESGVWSKNVKIFNIANARIIMEWSNKHQNGWKPQFTQDENLFAKGTFNQKEIEFFDMSNAANVEQVTSAAFRYKPELPYQSFSISPGLNPYLAIFTPEKSGKPANVSIYNIPNFNQAVCSKNFFKAEQCQLKWNSLGTALLALASIDHDTTNQSYYGETNLYLLGIAGSYNSRIDLKKEGPIHDICWSPTAREFAVIYGYMPSETSFFDARGNLIHSLPTLPRNTILYSPHGKYILVAGFGNLQGTVDIYDRQDKFRKVVSFEASNTSVCSWSPDGRYILTATTSPRLRVDNGLKVWHFSGRLIYYREYTELFAVGWKPAKVEDFPAISKSEPIPGPEASAREYLEKKQSAASSSAKKPAGAYRPPHARNGDSAPKATSLYQRELASSNQPSTFTPGIRQRAVPGAAPVVAKESKTAAKNRKKRETQKKKEEEDEAAATAAATAAATSAESTPKPEEAQPEAGAVVGGVSSIEEKRIRSLLKKLRAIESLKMKQAYGETLEDTQISKINKEDEIRKELDNLGWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW63</accession>
    <name>G3AW63_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_117349</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW63"/>
    <dbReference type="STRING" id="590646.G3AW63"/>
    <dbReference type="eggNOG" id="ENOG502QS8N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044602_0_0_1"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="433" mass="49865" checksum="639854A8B12DA936" modified="2011-11-16" version="1">MRHRVTILNHEQNHDNIIGSVNSTYLHLNDVNYTREDRFSMEFKNKFQYIKQLRISAGNFDSPVFHYNTMGLTIYAVPSTSNKHDFFSEINPFLMNLFKIDIQDSNWILSKNALLLHIPQYEMSPMNKLLMELTNIKVQTDVVDFLYDSDKLVVSFINTDRSAIIKSSDPSVYEEIGIFLIDDNSTADDMILSGLRVVLGEESPLFKTLFHIKPRFRSVSTTSEVIRNGLHPKVKTTISSKQAHPSDPDVMDCKLYYYLTLSKSLFIDKYDLGDNFKFVLNFGNNDLELPEYKINEWGNEVLLEVSDWSKDMYLNLHSRYQLPSQSHSTSKQVQVDSPIVFFGCDDTSERNILQHNPFINDFPIGNKYAQFFTNDTIFYESITNAKLQVDIPVPNKDFELVGLITSVSLAVGLLIIILQLLNTKTTITKKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWW4</accession>
    <name>G3AWW4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trs120-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_117749</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AWW4"/>
    <dbReference type="eggNOG" id="KOG1953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002231_1_0_1"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="370"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="616"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="782"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1213"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="723"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1352" mass="152606" checksum="B7903C73573BC21E" modified="2011-11-16" version="1">MLSNRYNYVAPARVKVLVVPINHPTPAEFDGFVATLRAGSEIRLLDITPMSQLKYFNPQSFPSGKLLYEISTSVPDNESIFLHDFEPSRKTFIVLGVGKYSPDVDTDGEKFNSQLKKLYPSTIVQNTIMFDTPDDIIKVLNPSNNHSMKSCFYFNSTKQNLTLMETIMCEVSRNFLFHLDEYATSYQNITLRSPVSITNSQLLAKTINKAQKRLSSGGTGSLKVSFNNNGTVTGQMDAKNKTQVRNNGRQSKLMASFYLLAGKYVDALNNFTDALLYLRKSDDSVWLASALEGVGVVIILLNHISVPYQLPNAVLATVLSLSKGKIRDMSIDNVARRVSNDSLSRVPSNSNSPNGHAITSPRPDLGLVAVPELIKRITIKVDSFFQNSTDDFENTVPDIVYIESLLRQINFMVAVFNRGIDVNHEFYTGLVNGTIKPNGHRTNPWFTAADILHEVDKIFSLQLVDLNLVDQCRIYCSIASTYNELGMYRKKAFMLRTLLVEITESAPGNGATGSEQVKEIIELLFFDYGIDLNDQESKTNSGSQWRSIQLQLLKIAIHIFESLGDHRYLVKLYNLALTKYLHCLPPDDQLRLKQKLEDLKVSNPDLPLPYWDPFLVRSVKFIPNSNKNELVPFPKDSLPKSSGNEDAHAPFIFNPFEKSTAQTFSNEKLLIKDELYQLKVTLQNPFSFELEVSDISVSSADDFPLETVRMALGPANEGLFNGRPKLNGLNSPVPSRSLTQSKFSVNNPKSRNEKALADSKSASAPGLNTFDTNGTTSYNSTTSHVVSLIVPANSFEVFTFPFKALKSGEVCLDGLHISIGKCDSSKFYIVKDVKYDISNKIKPIKDKKPKDSEDSSSSKATSEQITRSVLNLNVIEPQPTLSLVDLSVTNGWLMLLEGEKYKFSIRLENSSKEIINYLSFSFWDSTIQMWTSRLSNSVVGNQLSALEIYELEWLLIKLKSFKILNKREISEKYNTIKPNQEIRINYEVTGKKNMTESKIILEYANKKADNPKNSFLKSIEVPLNLTVIPSIELINCDILPLFSSTLNGFKSSSANEKEALKNLGDLKLFMKNIDGNKDISDYCLIILDLRNSWSEELSISINFMSGADQVFKINDTLRPRKAARYLIPTRRVGFKDLDFNKRIPSLRNKQYVKDYSISEAEDLEMRQSFWLRENFLSRISGKWSNSVRHGTISFRSIRLTNKMVNSLMYSRIKITHHILNEEDLSCVARSGVHLALQTEQFYIMRTVITNYSDQPISGILRHLPYPLINSSQNYSQIPHKDQLNIDKKILFNGLLQLKLPEVVEPNQSLTVDLSFTILERGEYEWGSLLDAVSDSIEAFKVTSRESVYVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXJ2</accession>
    <name>G3AXJ2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_91559</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXJ2"/>
    <dbReference type="STRING" id="590646.G3AXJ2"/>
    <dbReference type="GeneID" id="18250088"/>
    <dbReference type="KEGG" id="cten:18250088"/>
    <dbReference type="eggNOG" id="ENOG502QQ1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025632_5_0_1"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV66398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="421" mass="48284" checksum="4A8D59F440F69002" modified="2011-11-16" version="1">MFGLRAFKCTKHVIGDRASFSAVRWQSSKSTPGNIDFYTIRDPKLRDIIESSSFGSEKTRPLDSNSQSTTQSKKPAPLKSSPLISNTKYDNTSTSSTQAENRATSYETFTTKIKQDIMEKVDKLPSQKEELTMNITKSFKKYMDRLHPTVLQATKTLNDVTGYSAIEQLRLTIDHLENDLKAAKEKVKEAKSNYMAAIQERSLSQKEVNELLTRKHTWSSEDLERFTQLYRNDHVNEQNEASAHEELNKAEQMVDSVQLKLTQSILTRYHEEQIWSDKIRQASTWGTWILMGFNVLLFFTATLVVEPWKRRKMVDSFDIKVKSAILEFSQEQRGKMDTILTNQAQNSKVFEDTSKSGEPYSIRLPFHTWATFKQACISNYKALTSPLTTTLIFDKTDFGLFVSLVSIFSCTIASLLTIYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXN2</accession>
    <name>G3AXN2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_118124</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXN2"/>
    <dbReference type="STRING" id="590646.G3AXN2"/>
    <dbReference type="eggNOG" id="KOG2751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024219_3_2_1"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="158"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="296"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="479" mass="55029" checksum="CAFB3B085FFC73A4" modified="2011-11-16" version="1">MSETFYCQRCNNRLRLHESLLSLNTVQVNLLRDKGNPQLNHYTRHSQVLDDADDLDPTQFISSEKLQFYNKLSPNKTVPVIERNESASHDKLTSVSTSLTSNSFVMLSENSDNEHNEDDELSSNHHEEDHADGPISSRLRLLAKVFELLSTSTEVDHPLCQECSALVIENYKHKFDQNQKEKEYYLSFLKKLRDQGELVEGADIDPKLAQAIEEYSKLEAQESTKIAELQQLEHTKTKLDEQLRQLQKEFDALQSGELNEILATRNGLSLELNASTARLGQAKAQYQHHLDHLDRLRKLNIYSQFFDISCDASNQFGTINGFRLGYRVPWSEINTALGQVMLLMVFLVKRLKLHLRGYKLVPMGSQSQIIKLVDEEDQTVRKSTLNLYSSNEFSLGKLFNFNKFDVSMIALLEVLEQIHQTLKKLDPELELPYSISHRRDTIGGKSIRVTSNSEWTDGCKFMLTNLSWILRYTSAHTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYE2</accession>
    <name>G3AYE2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endoplasmic reticulum chaperone BIP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_102381</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYE2"/>
    <dbReference type="STRING" id="590646.G3AYE2"/>
    <dbReference type="eggNOG" id="KOG0100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV65832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="681" mass="74568" checksum="8A0012E392F21255" modified="2011-11-16" version="1">MIFKSNKTLGLSALTMFYLIFLVVLPFFSHKSSMALASENDTESYGTVIGIDLGTTYSCVGVMKNGKVEILANDQGNRITPSYVAFTPEERLIGDSAKNQAPSNVENTIYDIKRLIGLKYKDKTVQKEIKSLPYAIKEKNGKPVVQVEFNGEEKTFSPEEISGMILTKMKSIAEDYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLNVLRIVNEPTAAAIAYGLDKSSEEKQIIVYDLGGGTFDVSLLSIEGGVFEVLATSGDTHLGGEDFDNKIVKYLARVFKKKHDIDISSNKKAFSKLKREAEKAKRTLSSQMSVRVEIDSFVDGIDFSETISRAKFEELNMDMFKKTLKPVQQVLEDSGVKKSDIDDIVLVGGSTRIPKVQELLESFFDGKKASKGINPDEAVAYGAAVQAGVLSGEEGVDDIVLLDVNPITLGIETSGGVMSSLIQRNTPIPTKKSQIYSTAADNQPTVLIQVYEGERSLVKDNNLLGKFELTGIPPAPRGVPQIEVTFSLDANGILKVEAADKGTGKSESITITNDKGRLSKEDIDRMVQEAEKYAEQDKEVKEKIETRNSFENYAHMLKNQLKDTTETGLGSKLEDDDKETLDDAVKEALEFIEDNYDTATAEEFEEQKQKLIEIAAPITSKLYAGAGAGAGDEAQFGDEDSDDDFDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYP8</accession>
    <name>G3AYP8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_112777</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYP8"/>
    <dbReference type="STRING" id="590646.G3AYP8"/>
    <dbReference type="eggNOG" id="KOG2299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_1_1"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="79"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="38267" checksum="605CA78CE4D985DA" modified="2011-11-16" version="1">MKRSLSISGDIDDHGISSQMKKQEQKDCQSQDELGNESDIEGESLFDGENWLPPPLRDISDNFNSIMYSSHIPKVGDTPLILGVDEAGRGPILGPMVYTVAYCKEDYESDLKRYGFDDSKVLKHEFRLGLYKLIDQKDHELNQKIGYLSSILSAKDISSGMLRVHQGNYNLNEQAHDATINLIKALVEKKVNIKRVYVDTVGPPEKYQAKLSNIFSSYNIKFTVTKKADSLYPIVSCASIIAKVTRDLYLHYYNQKDPLLRGTEMGSGYPSDPRTSRWLKEQINPVFGWHFGVLRYSWQTAKDSLDKNKAVEVDYEAETFTQPFKFGLSCFGTKTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYV2</accession>
    <name>G3AYV2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92281</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684510.1">
        <property type="nucleotide sequence ID" value="XM_006684447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYV2"/>
    <dbReference type="STRING" id="590646.G3AYV2"/>
    <dbReference type="GeneID" id="18250179"/>
    <dbReference type="KEGG" id="cten:18250179"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408316_0_0_1"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="653" mass="74612" checksum="6D071B1157A45945" modified="2011-11-16" version="1">MKDSLGNDIHGEIPSIGESKLSIDHLPPELLVEIFSKLELFQLRSIRLVCKKWNSVVSDPIVWEKSFRTKFGNDEIFPSFSGTSSWLVEYLSRLSNAKRWKKAPGQHLTYQVINEETGHNDSCLTNFYSDRFLSYSRVNNNVSICTLHNGKNQTFIPGNHYAVRSYSVNWNYLVFGTREGGLYIKNLITSTSSGNRSSVKEVIPDQNGPEDHEIIESIHLSQEFDKNKVKPDIITGSSLGVVSTYNLDGALVHSWKVGATIIRVFSDFKKHIIAFTSHTISIIDYTSHKVEEVTIDIQIGPETIIDIDFGDNNIVICSENHIRVVDYSDPTIFIRRLDLGFNIKRGKLQQLGHRTRRDTSLVGKDGLYYANVLDDDTVIVWNVRESTETIKIRCKFQTEFKYKELNFNRGIPPNGRDRDYTVNAVELNSSVIIVGGFNGYCNVHDIFTGKFLRECSIKFPKKYPYMYNYQIPVKDIQLNERFNITNGIILCADLVQYFQFGDSDRDNTKTEKKKSSIGEAVKKGHTIKKTIKDQLDDYDLEEYKKDELNKMFTKYNGSEFSSQEELSIAIALSKSASSPEQGDQQDESESLRRALELSRNQTISTEESDDEELLRVLELSKHDMVISPTSLQSANEEEDEELRRILELSLADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYV4</accession>
    <name>G3AYV4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_133367</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYV4"/>
    <dbReference type="HOGENOM" id="CLU_1255823_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="220" mass="24228" checksum="8BA8F2470252099C" modified="2011-11-16" version="1">MSPHCRNEFCGRRLKLKLHAHVPVFSRNCGYPVVLTLFCTKQCFAKGDFDLPTPQDLAHSLNLYETSDDTASLKFIAINYGENVTYYWPSINLTKVEYDSSGFEVLLEISNSTENENPPSSDLTKRAQRTCYNSNKSYKITGCSNCGKFKGYLSAHNCKSKGNKGYSCLEACKCVLNAPDGHCSSTQCDEYCGAVNAFATAEGGGCWTGKCKTETVHAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ32</accession>
    <name>G3AZ32_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_97062</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684567.1">
        <property type="nucleotide sequence ID" value="XM_006684504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ32"/>
    <dbReference type="STRING" id="590646.G3AZ32"/>
    <dbReference type="GeneID" id="18250653"/>
    <dbReference type="KEGG" id="cten:18250653"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="595" mass="65339" checksum="63C58358A22296F6" modified="2011-11-16" version="1">MVLFQSINNFADPQGGIGLPSARRRRLYIPPSTNYPLFSYGDGDDQRSFLSLIETGSHITDLDDDNSDAASVSTSRSLPSSLSSVNTDHESLRSWLLEESQRSYSAAQSEDEDNLSNHSRYSRTSLLSSKFSTHDFGSLHTSYSKELSVICQYSFPLIITFLLEHLFSIVCLIVVGHLGKDELAAVSLGSMTTTITFAVFEGIATALDTLCPQAYGAKNYELVSIHVQRCLLFSLVAYVPCAIAWWYSSVYLKYIIDSDNVLKMTESFLRILTLGGPGYIFFEVSKRFLQAQGIFEAGTGILFLSAPINIFLSWFLVWNEKFGMGFNGAPIATVINFYLMDILLILYVMFIDGKKCWFGLASVSDLCKQWGNLSKLAIPGIVMLESEYFAYEIMTLMASYMGTVDLAAQSAVSSIASLTYMIPFAISIAGSTRVANFIGGHNIRGAQIAIRVTLFVGLVAAFINCLVLFSLKSHIASIFTSDTDVKSLVIDLFNPLVSVIQIFDGLACVSSGILRAEGSQRIGGYINFLAYYAVAIPSSLALNKLFDLKLFGLWLGIGGGMILIAISEILVIVNSDWDHIMMKAELLNDAAFDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ76</accession>
    <name>G3AZ76_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_129454</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ76"/>
    <dbReference type="STRING" id="590646.G3AZ76"/>
    <dbReference type="MEROPS" id="C19.079"/>
    <dbReference type="GeneID" id="18249382"/>
    <dbReference type="KEGG" id="cten:18249382"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017549_2_1_1"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="103"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="478" mass="54716" checksum="ADF9EC93DBE9A28C" modified="2011-11-16" version="1">MVFTIKIKNAGKVQDVTLEDTDTGADFKLKIQHQTNIPTDKQKILIKGGKLNDDSVVKDLNLSQPVMVLGTPNNNINKVEIPKQVFLEDLNQNQLVKVSDEPSGLVNLGNTCYFNSSLQSLYRIDDIREGLKTANSTNSFVNSLKRLFDMMSKKQERINPTLFLASFRENFPQFSEQDNHGFYKQQDAEESFSQILNVLLESIHMKGKLTINLKTESKCLALPEEPVVTGQEDALKLMCHIDIKTNFLRDGLLNGLKETLIKHNDTLGSDAEYEITKTITKTPKYLIVHFVRFYWRRDTQKKSKILRKVQFPFELDISEMLDESIKPTKAKFRDDLRKIEKDNFEMVRDFKKAKKDDSLSPLQQQEEDQLKLESIKSKFEDDFNSLLKEHNIDEQLDSLTENPSSVYKLSSIITHAGSSADSGHYQSFAKDEGDLEDEHWWKFNDEKISRVSRDKIEQLSGGGESDSALLLIYKASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ85</accession>
    <name>G3AZ85_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112896</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ85"/>
    <dbReference type="eggNOG" id="ENOG502RMSE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_657243_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="383" mass="43522" checksum="427800C09E60D372" modified="2011-11-16" version="1">MSSQMQFTSVHSETLKKIRFYDEQTADHKYKMMSAVVSVLVVGFYTWRYLVLRHTRLTSSKYVVSGVLLAVWNFLMSVFADSLVLRLGAVENYYENMEASARSGSESESEFLASHQFWASDVRSLLVMIEGFVLVKVFLNTGCRMIEHIKDNVDEGQDLEKASNSSTDHQHLIPSKTRTFAPRKVARHAISFTIILAIMTMVLPKSLLLNSTSTIYSTPRITIKSDHLFWSISSIFISTAISTVSASAQYRKTCSFAFTGYCIILYQGLIVMATHGQMFLFHDMVLNMLSSIAHLASQDYKFEDHNINVFTSMLMSFFSHINESDCLHRLCGQSEQVEAMVKDLIYFRHVFGNCLTVMSASGFVLLPLILWIILVESTTYEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZK2</accession>
    <name>G3AZK2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_91922</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZK2"/>
    <dbReference type="STRING" id="590646.G3AZK2"/>
    <dbReference type="GeneID" id="18250130"/>
    <dbReference type="KEGG" id="cten:18250130"/>
    <dbReference type="eggNOG" id="ENOG502QSDX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014759_0_0_1"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1009" mass="115177" checksum="E60A5AA4C4588A59" modified="2011-11-16" version="1">MSFYDSNLKSKEQSSGGFHDQRSFNFSQRAMMRSKTIPIPSPLNLRSSPNDFLDGEQIRLKPIDLDYKDSKQLPCLPIGPDSSYNLQRPSHYQRTHVQPTPSTTYDSGISQANSPSLLHLNAQNQSHSQPHSPKVISPICTICNFFIDEDLLELSCNHICHRDCFINNILTCKKCPDNHSSLAPSFSDLNPQPLSNSISHTSHEYTSPTFCPVEVPMTPSDQMIPDPLYPPTHTLKQEVQQRDPQDSQEDVNGRLGYPKPSQSYLQQDRLSQQQSQLLSPRSSFNKNLNKDLFDSLMKPKVKFISEHEDCKVKVDSQVNDDYCLNYLISVKPPTFYNCINEDKNLVLKNQILEEIKFGILNNIINSNDENVIDFNSLGKLVIFEIIGISTNGTNWDQVRLLLFESCLILVDLKGEVLIGKISIDQDILNMTRFVSGIRLDLNNDTIPELQICCEIPLIISRLEYFFKKLLEKQFVSETSLFQLTTNGWGLIKENYSNLPVDIIRFQNCIENSLDIPESLLAKSMPSPELIPLNLILSITLLQSSSISNNEYRTKIISFLDRVRKDLRPIDRLSLIFVGIDGSGFPCKKGSFIGSVEPNWSGWDSIYNEVKVQSNLNSQHKPILTSHWDEMQLTLEKCKDLFPFLNCNSNNTTKLVVISCNDYEPTLVNNEKLNTVKTHFKTLLNDSDKNLSVDFFRVGDSYTPELEFGQKICSQPSLIFNDILKIPHSSSLRRFNNLDEFSDEFLSILKSSYHQICLPAISLDISKIIGTRDIVSFHKIEVNGKMLEIENFSNLKIFFNNITVNCEETIMLKLRLNMTKLKSENLDYNDKVVDLPLLSYMPSWLHESDDYKVLHTQIYQNQQASTFNSFLDGSLTPPSTNECSAFFTSDFPVKSRKYVRKEIEIEIIKGLALISQNQMLHNQDILRHLIDFIYNRKRLFEETESSSLSESTKSSNSSLKQSKFSPHATELSSNNYIDSLLHKLGNLMEMFNVNDPSVLTACKDFKSLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZP9</accession>
    <name>G3AZP9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TMS membrane protein/tumor differentially expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112513</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZP9"/>
    <dbReference type="STRING" id="590646.G3AZP9"/>
    <dbReference type="GeneID" id="18246553"/>
    <dbReference type="KEGG" id="cten:18246553"/>
    <dbReference type="eggNOG" id="KOG2592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029574_2_0_1"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="480" mass="52211" checksum="BF1546D76E75AC41" modified="2011-11-16" version="1">MGALVSIPLAGTSTLVSSAASCFGAAACSAFCTSIGGTFQSSILTRITYAFLLLFNSLLSWIALSPYVVHKLEKASFGFINNNCGAEGGQCISFASVHRINLALGALHLLLAGLLINVKSTTNPRAAIQNGWWKLKSLLYVVLILVNFLLIPDGFFVFYGNHIAIIFSTIFIGIGLVLLVDFAHAWAETCLEKIELEELTGDGEYNAGFWKKLLIGGTLLMYVSSIVVTVLMYGFFANKGCSMNITAITLNMLFAIVISGLSINQTVQESNPHAGLAQSSMVVFYCTYLVMSAVASEPDDMNCNPLVRSRGTRTASIVLGAFFTFIAMAYTTTRAAANSAFFDDEESTEMASGLISSQPSGRNEMRYQAIKQAVDEGSLPESALNQLSLYDDEGTAADEERNSVKYNYALFHVIFFLATQYVATLLTINVKQDEVGDFIPVGRTYFSSWVKIISSWVCFALYGWSLVAPVVWPDRFGVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZQ2</accession>
    <name>G3AZQ2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_129123</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZQ2"/>
    <dbReference type="STRING" id="590646.G3AZQ2"/>
    <dbReference type="eggNOG" id="KOG0344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_4_1"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000759">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="150"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="337"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="525"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV65639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="556" mass="62478" checksum="B7371051944BC393" modified="2011-11-16" version="1">MDIFRVLSRGASLRKSKQYSADFSLPTQGELSTETRKEKTLQHEIDKETDFFHTKRSTNIEPQDQHQLATDEPANVVTEVPEVPPLQISTEEDAATFRKINKSKVSGNDIPMPIGSFEDLISRYDINKKLLDNLLRSEFVEPTPIQCESVPAILNERDLIACAPTGSGKTLAYLIPLLQKFTATPPVKNSGIKCLIISPTNELATQIFQNLDILSRGFNLKLGILSKQLANKLTEKSVNSDKHDILVATPLRLIGLIKSESINLSKVQNLVVDEADKLFEQGFLQQTDTILASLNSKNVQKTMFSATIPSGVEEICQAIMIDPLRVIIGHKEAASNTIDQKLIFTGNEEGKLLAIRQLIQDGEFKPSIIIFLQSIIRAKSLFHELLYDKLNVDVIHAERTPKQREEVIKRFKNGDIWVLITTDVLARGVDFKGVNLVINYDVPQSAQAYVHRIGRTGRGGKQGKAITFFTKEDNKLVKPIINVMKQSGCESGYSEWMENIDKLTKKDKQLLKKNQITRKGISTVPKVVSHKRKQKQQMIEASKRRKHMETEEAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3B005</accession>
    <name>G3B005_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_113022</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B005"/>
    <dbReference type="STRING" id="590646.G3B005"/>
    <dbReference type="GeneID" id="18246789"/>
    <dbReference type="KEGG" id="cten:18246789"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_1_1_1"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23811">
        <property type="entry name" value="UBCc_ScCDC34-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000063">
        <property type="entry name" value="CDC34p Ubiquitin-conjugating enzyme (E2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="241" mass="27581" checksum="630F592A849A4A34" modified="2011-11-16" version="1">MSSKSAAAILQRQFRDLTDPKSGIPSFHIELDNDNIFLWNIGIIVLNQESVYHGGYFKGQMRFPSDFPFSPPTFRFTPAIYHPNVYKDGRLCISILHQGGDPTSDEPENETWTPAQTVESVLISIISLLEDPNVSSPANIDASVELRKNPEAYKKKVLQEVEKSKKDIPEDFIMPESEMYAFGNGSSSNKDNEHDQVDEDFWYDTEEESFDEESLMDDMEMEEDNEDDEEEENDDVDIMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B033</accession>
    <name>G3B033_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_119522</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B033"/>
    <dbReference type="GeneID" id="18248707"/>
    <dbReference type="KEGG" id="cten:18248707"/>
    <dbReference type="eggNOG" id="ENOG502RJGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160155_0_0_1"/>
    <dbReference type="OrthoDB" id="3989460at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="106" mass="12140" checksum="FFDE98A1FEDD9E89" modified="2011-11-16" version="1">MSDPESDGDLHPIELIAHSVLSGPLDSLNENFDSLHQSQVILLTRLKLIEERLQKFEDAHSTIDKKDVSAVLQRVKTIRKRLHATKKRMDKIDKRVDGMGERLDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B052</accession>
    <name>G3B052_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113038</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B052"/>
    <dbReference type="HOGENOM" id="CLU_1895928_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="134" mass="14735" checksum="BB36F182B19C6912" modified="2011-11-16" version="1">MSLPITLPSLARTNSNSRDFPRSVPTQSSISDRFRPSLVEMYKFHDSISTSTNNSIFSNSSSISSIASQRDNSIGSIVIPSKSLTPPPPVSHKMTAYSPITRSASSSNLPVHKVTINSLLKERDESKRRKLNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B055</accession>
    <name>G3B055_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92541</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B055"/>
    <dbReference type="STRING" id="590646.G3B055"/>
    <dbReference type="eggNOG" id="ENOG502S12N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078573_0_0_1"/>
    <dbReference type="OrthoDB" id="2405700at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038910">
        <property type="entry name" value="Hua1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="258" mass="28042" checksum="0687DD2D594BAEF9" modified="2011-11-16" version="1">MGPDDYDTSLPPPSYEEAVSTPVHTGTTTTNTAVRPAMPPPQPPPPPRPSHSSPASQSPAQSQLNDLYTANSKLPFRYPKGFFCNKCSNTGYRKRGKYCHNCWDQFYLKKHAYNPNPGLAFRYPRGFYCERCNNTGTKVSSGRTCQDCYERFAPRNNYSMMSTSGSGLLGLLDPFARTTTTFAVPAPAGAYGAPQAYGPPGGYMSGPPPPPLRVLPGDPRLGGVLCGRCRGSGLVHFFLDEEMCPVCGGMGRILNVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0L6</accession>
    <name>G3B0L6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113178</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0L6"/>
    <dbReference type="STRING" id="590646.G3B0L6"/>
    <dbReference type="GeneID" id="18246843"/>
    <dbReference type="KEGG" id="cten:18246843"/>
    <dbReference type="eggNOG" id="KOG3372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068714_2_1_1"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="189" mass="21172" checksum="FB9DEC4B49C601CD" modified="2011-11-16" version="1">MFNLVTRAQAISNHAITCTAIIAALVIVSSFFQLQLDQVWSLNTTSISNVQAGASLKGSFQYGAKNGKQKENSIIKFDLDADLTPLFNWNTKQVFVYLTAEYPGKSDGSSNKVTYWDKIITSKDDAVLSLKNHRAKYSVWDVENSFRQRDAELKLEWNIQPHVGPLIFGQTSATTPFTFAEVKTKKDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0T1</accession>
    <name>G3B0T1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative MoxY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_93034</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685600.1">
        <property type="nucleotide sequence ID" value="XM_006685537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0T1"/>
    <dbReference type="GeneID" id="18250249"/>
    <dbReference type="KEGG" id="cten:18250249"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="OrthoDB" id="4023354at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="569" mass="65240" checksum="3918D20809B40A34" modified="2011-11-16" version="1">MTGAEYTIKEEPAFTPRKIKIIVIGAGASGLNFAREVYQNVPSADLALYDKNPSIGGTWYENRYPGVACDIPSINYQYTWAPSTDWKKYYSSGPEILAYFKKVAKEHGLDKDVHLNCRVVACKWIEEDKKWEVTIQRGEDPNDTFIDSAEVLINATGVLNKWKWPAIKGLENFKGPKLHSANWDTSLSLKDKRVGVIGSGSSAVQIVPNILPQVKSITQFVRSKFWITAGFAQKFAGPKGSNFEYTDEQIQILQKDPKKYLTYRKNIESDLNKRFRSVLKGSIEQKEARAFAEQEMKTKLAPKPEIAEKVIPQDFGVGCRRPTPGNGFLEALCDEKTNLVYDDIDEITETGLRTKDGKHHEFDVLVCATGFDVSWVPHFPLIGRGGKDLRDEWKEKPETYLSVSVPNYPNYLIFMGPHAPYAHGSVLPMTEAIAKNFIKIIQRVATESITSFEPKQEAVQDFINQRKTFLQRTIWNDPCRSWFKQGTYDGELMMWPGSRIHFFEIMSSPRWEDYNLTYELDNRFSYFGNGFHVREFDNRDLSWYLGLLGDKDEEPEYSDEYLKEFLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0Y0</accession>
    <name>G3B0Y0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113597</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685945.1">
        <property type="nucleotide sequence ID" value="XM_006685882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0Y0"/>
    <dbReference type="GeneID" id="18247037"/>
    <dbReference type="KEGG" id="cten:18247037"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034490_0_0_1"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833545" evidence="8">
        <location>
            <begin position="17"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="99"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="538" mass="57856" checksum="81321EC934CF74F9" modified="2011-11-16" version="1">MKTAFFLCYLASYALGLHPVKDFRVSDLKVSSSKQRVVSANSNAVSYKKADDTENELSVVGSATATVVTTSSLPSSAPTIALNADVQMVFSDTTKSIYYLTSQVIDNNTNYNETFQLLLDTGSSVSWVYNESCTSDACTQQTVNKFDDFSQNLHILSDFSLTYSGQSVSGDLINGKDNDIKLVFSNFELSNFTFGIASTVPDLFDGFNVSGILGIPSSTAKGDDKNLIYQLNQGQLIDSQMFGLSLVSSNQTVEYTDDDGNVLSLPSNYGGLIVFGSKAIDDQSNFIESGSNISFTPIVENDNDYWLIDLKNIQVDNGTVVKALNSSDSSRKTIIDTGTTGFVLPLTDANTLHEKLFGSDLVTDNNGNYAFPCDAEDQKFTFTINDHDFEISVSDFKGEQYTTQGLTGNCASMIQGLNSQHWVFGAAFLSKFYTVFDLDANRIGFGDARITSYSLQQSNSAGTSAVYTGAITNSSVSSTSTRSGSSIVSTSSSSISSHSHSNNSTSSTDDDNESHNSGAVVAYSGLTLLMSLISHIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0Y6</accession>
    <name>G3B0Y6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_104139</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0Y6"/>
    <dbReference type="STRING" id="590646.G3B0Y6"/>
    <dbReference type="GeneID" id="18245689"/>
    <dbReference type="KEGG" id="cten:18245689"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027451_0_0_1"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12397">
        <property type="entry name" value="RRM2_Nop13p_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034226">
        <property type="entry name" value="Nop13/Rnp24_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="93"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="197"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="360" mass="40933" checksum="5C3D890AA49C28FA" modified="2011-11-16" version="1">MSDKESKDEKRQRKLEKKQRKAQEKADSTTSDLEEIEIDLSADIPLNKKQQRLLKKGKLNLDKIRKKHPAPKPATDEGADGEETQSKPERSKFGVWIGNLSFDTTREDILRYIKAKTDVEEDDIVRFNLPKKQNKIKGFCYADFKTEDQMNQVIKLSETNLNGRNLLIKNAQSFEGRPEADKSDNKLISASKNPPSRILFVGNLSFDTTEDLLEEHFRHCGEIIKIRMATFEDTGKCKGFAFVDFKDEAGATAALTSALTRKLINRPVRMEYGEDRSKRTPKRFLDSERSNARERTAGESNDHHEPTGETASEPVYRPPVKRPRREYEDKSRVKSSVALANAQRASAAIVPSSGKKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B136</accession>
    <name>G3B136_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_104213</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B136"/>
    <dbReference type="STRING" id="590646.G3B136"/>
    <dbReference type="eggNOG" id="ENOG502SDEV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_9_1_1"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="77" mass="8646" checksum="5B52E7CA119CE831" modified="2011-11-16" version="1">MTTIAPEKFIGSSLRVELSDNRVLDGVLTVVDPFGNLLMSNVYETNKSNRREVGLVSVPRATISKLYIDKRTYQSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B152</accession>
    <name>G3B152_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="12">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_113640</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="12">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="12"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B152"/>
    <dbReference type="STRING" id="590646.G3B152"/>
    <dbReference type="GeneID" id="18247059"/>
    <dbReference type="KEGG" id="cten:18247059"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_3_2_1"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01060">
        <property type="entry name" value="Membrane-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="394"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="510" mass="59164" checksum="675E2B34F72B3B06" modified="2011-11-16" version="1">MNEEVKSRYRVKKKKKTQDVNHHLLNHAATIKNSQMNQMHKRKRDLLKRINYTHTFTVLVMPVVAIVYLSRYAVSVIPQNIATLWFSVAYFNLTMLAFTCGYHKFFTHNAFITNSRVLQYYFAIFGTSMGLGSIKWWGSLHRAHHQFTDDTNKDPYSIKRGFYYSHLGWIIKRPKIESFYNSFIDHEFVKGAIDNDIFDVDVIDMEFDELDTQRKQYNERIKRLILWQHEVYFLLFITTTIIIPAVITRFYCNDSVLNGIIYPGILRMFLCQQCLLSTESICHFGEIKVSLPTQPFNDNNSAINCNNPLISILTYGQAKQNFHHEFPHDYRNDSSKFSFDPTKWFLFTLSMLGAIDNLSVTPSDLITQLRIQQRQKVLNKVKSQLNWGTPISKLPLITPQEFKRFIATSAHEDRIYIVISNVIHDITPFMEQHPGGLPLLKASHGKDATKAFFGGVYSHSTAAQNLLATMRIGYLDNGDEEEVWNKIVKEEGEVQDKSHRQEAYKSAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1F9</accession>
    <name>G3B1F9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_121207</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1F9"/>
    <dbReference type="STRING" id="590646.G3B1F9"/>
    <dbReference type="GeneID" id="18248831"/>
    <dbReference type="KEGG" id="cten:18248831"/>
    <dbReference type="eggNOG" id="KOG1946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046065_1_0_1"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="129"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="252" mass="28666" checksum="14F5D0105A2FAF76" modified="2011-11-16" version="1">MTSEYKPKEYLPTIDAILGVADLEKVSVKKIRRALQELFAINLDEHKSSINELILERYHNLADERKQQNDKSEKQRREEMIKQDAILALKLSKEMSVPVRNALNRKKPSKVTKTKKSTSSEDKPKRKSVFQREVQLSAPLSEIIGVTSAPRGQVVKLLWQYIKGNKLQDPNSGRTILCDEKLENLFKKKKVDSFAMQKDLVKHMFYDKELAEKKEAAEAAAAAYSSVEPSASPVPSSRSPEEDQFSESSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1J9</accession>
    <name>G3B1J9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_92694</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685270.1">
        <property type="nucleotide sequence ID" value="XM_006685207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1J9"/>
    <dbReference type="STRING" id="590646.G3B1J9"/>
    <dbReference type="GeneID" id="18250221"/>
    <dbReference type="KEGG" id="cten:18250221"/>
    <dbReference type="eggNOG" id="KOG2316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_2_1_1"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="637" mass="72964" checksum="EE26ECAF38C29A44" modified="2011-11-16" version="1">MKFLALISGGKDSFYNIHHCITQGHDLIALGNLYPKNTQQDEIDSFMFQTVGHDIIDNYAKCLDVPLYRQAIEGRSKNQELEYSRTEDDEIEDLFKLITTIVKNHPDVQAISCGAILSHYQRTRVENICDRFGLTSLAFLWQRNQDQLMREMCDSRLDARIIKVAAIGLDAKHLAKSIKELYPYLVKLNKMYDVHICGEGGEFETIVLDCVFFKHKKLNMIDMRVVQHSSDVFYLKFGIEVVDKKEEARIPFASAIVPSLLENSFQEVLENSVISEEFYPAVSSNSTPYQLSSKVCSVGNNIFISNLVDSSNTIQEQLSNIFIRLEEFLKDANLSLNDIQHITLLLADMDKFSEINGIYSSKFIDLYLPPSRICIETSLPDPYQVQLSCRCIIKETNTKKGIHIRSRSYWAPQNIGPYSQARVEEQKDFNFATISGQIPLIPSSMELLSSGNETIALTIQHFDRIRALINVQEISTILCFVTHELNLDSLKQIWHTYCQTDSHQSLLEKLIILNVSRLPRNASIEFGGETFKSVEDLLEEDEEIEKTDHNDLIIWIKETFPDLILTQLKDSVSVSIFTDSATDLNKLMNDLNGFIRVYCSGEDFKKLDNFGEFMPVSQVMNFQMRNYKYAVSVIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1N1</accession>
    <name>G3B1N1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113253</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1N1"/>
    <dbReference type="STRING" id="590646.G3B1N1"/>
    <dbReference type="eggNOG" id="ENOG502SDB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062460_0_0_1"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33221" checksum="EED87C5EF89CEE72" modified="2011-11-16" version="1">MSGTPVLSYKKPSTQKDVKATAAYTTISSMPKDAGTMSPNVGVANASGTRKVSSRRKALQEFYHIQQQRKQQEQAQVQEQEQKVPVEAEVDPINLEDPVRFQEYVKTTPIQDILKLRNSIGSELNSHNSEKKSIIYDNYYELIKLNQTLQKLSTPVVPAKDDNGEAFTGLKDLDETGPKIDEHYILSSLNDLKDFLDTKANVYNDSFVNVITNLQAKYQTPDSESVSSVRGVINDGEDVVVFPESVEKLDLVNEINLVLSSSSTGEIAPKIDAIMSKLDANKDELLILQLNDVKKSALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Q4</accession>
    <name>G3B1Q4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113271</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685310.1">
        <property type="nucleotide sequence ID" value="XM_006685247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Q4"/>
    <dbReference type="GeneID" id="18246874"/>
    <dbReference type="KEGG" id="cten:18246874"/>
    <dbReference type="eggNOG" id="ENOG502RPID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109474_0_0_1"/>
    <dbReference type="OrthoDB" id="3991133at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="204" mass="24610" checksum="AB8E7E73D01C123C" modified="2011-11-16" version="1">MIARQIPLILKSPINSPVSMAYLWSLSDDKKRLACLYKRFYRLRNLIDHDRRNVSRYKELIRWKFAKENYNTRRSVILGKPEEPISEIFTRIFNTLTFVHNSTVILPENMIDKKAYFYKDTRQNHRIEKQIILTICRMQYVTPNELKYRSDFSWFPEVRKEIEDFPENATKRQMAKSTSNPSYIGFADYQKNLMLLNEMYKLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1S8</accession>
    <name>G3B1S8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_133830</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1S8"/>
    <dbReference type="STRING" id="590646.G3B1S8"/>
    <dbReference type="eggNOG" id="KOG4775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261453_0_0_1"/>
    <dbReference type="OrthoDB" id="4070448at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="1">
        <location>
            <begin position="662"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1168" mass="138371" checksum="AC0944739DC343E4" modified="2011-11-16" version="1">MPPSERSNQLNEVIHGLYEVFFGSQTLSESQCFQKLSTVSDQLLWLLEYKEANVTKLELKGTYNKYFSDELSLNMYHIHKYEPDSIIFSQSTIFDTIRNTHLHPLEESHLSSMIDQLNVIKDQYSSLEGYSKIVQGLEKLVHFYSQLVSESEVQLVRFLNKNFNNELRQLSNLQLQLEELDIYLEESSTREISSYIESLPIHTTRPESPSTSLDNHSMYQGFQNKSGFESSDTNFKNLVYLFLQISSFKFKSSPSDHDFSSNIKLMLAIYRRNCHINWMEIADYQTLEWKLNTFHDFLFGMIQEDLDERHVLKAVCERIFATQTFFPELATDELPNSSAIDDSHPSFSRSSIILPREDEEELLANVERLLPQLNEFNFNFDPSFPKSLKLFISLLDPNQELTTDSDLQYLNDLIKTINAIVDYENDEAVNNGGDIYNASLQFYNLHMSLSIDNVNKSPSSTLLMKYCMCQVKHDTCTITNTLQKWNLKTLNISQLNYTLDHDWGYYQSSKVVRSVFEAWLGSFDRHKRMSLAASEYHSKSIQVKILFSKWIPKSVSIKSLIERESDHCRTKAFKKWKDRYTKTQEQVSRACEVRRSKVTQTVFEHWKTRNETLMTMTFKSQSLRETHETKLDALVLSYIFNNWFVKMNRSSSNQGSGLGLQDLTDKLKLLSVREKDFLLRRFYHIWKNKHDMEAREREVISNNSKFLSRYFFSKWEHLYKLRFISNDFQNQRNSKFKTNAFSHWKGSTEINSTASAFHRKKLLRRIWNTWKLKTLARRFPRNKLEVAKQRSSPVSNNEFIYTQLQITFKKWYLVFKCNQLRSNNELTLKSLAFTQWRGKSMRNIDMIHAARTFKEKSLIHSYTMAWYNVLEFQQRLPSIADTFYVKSYWKILQSKSELYSVTLKNLKDVHIDKYALRAKYSIESQILVHSVLKLWKEKRQQRFDDLADLKITYLHRRITVPNTLKKHLVKWISTFNRRQMKSSTLDQRCQMFLKRSRMKRFFLDKWIKKVSHVINLSEISDSFGSRLLHKKHMVIWYDKYLNKGRYLEEIAQELIDQKELKIQREVLSEWSMKYIKFITRHQQSCNLFTRRWETARLKSIFDLWVYKLQDEGDDPSQVSFDSSSPTKRANVFLDMSTDSIILSESPLAFKRKAPTKYSPGKQLQSQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B209</accession>
    <name>G3B209_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_97451</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B209"/>
    <dbReference type="STRING" id="590646.G3B209"/>
    <dbReference type="GeneID" id="18250685"/>
    <dbReference type="KEGG" id="cten:18250685"/>
    <dbReference type="eggNOG" id="KOG0276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005507_1_0_1"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="321"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="663"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV64577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="889" mass="100328" checksum="59D959408964B7FE" modified="2011-11-16" version="1">MKLDVVKQFSIRSERVKGIDLHPTEPWVLTTLYNGKVEIWSYATNSLVKSIQVTDLPIRTGKFIARKNWIVVGGDDFQLRVYNYNTGEKVVQFEAHPDYVRYIAVHPSKPYVLTCSDDLTIRLWNWENNWKLEQVFEGHQHYIMSVNFNPKDPNTFASACLDRTVKIWSLGSPTANFTLVAHGSKGVNYADYYPQSDKPYLITCSDDKTIKIWDYQTKSCIATLEGHLSNVSFASFHPELPVIISGSEDGTIKFWNSNTFKLEKSINYSLERLWCMSVLSNSNLLAVGGDSGYVIAKLGNEEPLYSMDSNNKLIYAKTSEVYQSILKPTITEGLKDGDSLSLQQRELGTIEIYPQSLAHSPNGRYVAVVGDGEYIIYTALAWRSKTYGKALELAWNSHDFTNNSTFAIREGPLSVKIFKNFQEEFSLSLIYQADKIFPGYLLGVKSDGCITFYDWESGKLARRVDIDDDILDVVWSDNGELLSIITAPSSSGAAANSDSNTGSTKTSYETYFLTYNHEIFQEALDNDQLDPEEGAESSFDVLSTLPSSEAILSGKFIGDVFIYTTSSTFRLNYYVGGEVINLGHFDHKYYIIGYKSGSEGKLYMIDKSFNVISWFVNSDVLELQTLVMRGDLEQFATEEIEDESGEPIPDVSNITEDQLSEEYSNLMKDFNKTEMNQLSRFFEKLGYLSLSYSLSQDFDSKFQICLTKNDLSQAYKLLLESQNENLSSALGNASKWKKLGDLALNQWKIKLALDCFWLAKDHASLLLLLSSTNNVKELTKLAEECETTGKYNIAFQAWWIIGEKEKCSKLLQKGEKFTEAAFLSKNYSLSSEIVSESVDAWKSKLSSINKSKVSNRLIADFESQAPADSLIDLKEPKQVITEAETKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B236</accession>
    <name>G3B236_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1689-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113370</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685846.1">
        <property type="nucleotide sequence ID" value="XM_006685783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B236"/>
    <dbReference type="STRING" id="590646.G3B236"/>
    <dbReference type="GeneID" id="18246921"/>
    <dbReference type="KEGG" id="cten:18246921"/>
    <dbReference type="eggNOG" id="ENOG502S01E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087023_0_0_1"/>
    <dbReference type="OrthoDB" id="4010386at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012470">
        <property type="entry name" value="Pup1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07954">
        <property type="entry name" value="DUF1689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="290" mass="32610" checksum="3979D9A65D9F0E2B" modified="2011-11-16" version="1">MSTNTESNDNSNGTSQASVPLSPENPLTKVLTPAQFNASVHFYEADQQLTPQDRTEIKKDFERILPRISIASNVASLVGFFSLTVFKRLSNPVQDLTANPNPLKPRSFIHKPFLSFLCGLGGLVLGGEIAGKQQFNSQIVRLQGIPEKERQLGVWKTIERHQSSMFYLYYRRTSEDPSYILKDPREFTATQKHEVHYHPPSPTSSSKVFRKDDDRQVIDPVTKDLTVWERVRVANGYGTNPNNSLETSDTSIDSTAEFDGGEIVTTEDESERTIVPTSAWERIRKSSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2J0</accession>
    <name>G3B2J0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_120534</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B2J0"/>
    <dbReference type="eggNOG" id="KOG2993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000626_3_0_1"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1590"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1597"/>
            <end position="1611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1714" mass="194341" checksum="B77B117E413E6B5C" modified="2011-11-16" version="1">MSPQWLPQNIQKRLLLYVLQQLSLFSEIDLPNLEEVSLNNIHLKDISIDPEKVGKLPGCNLRYGQLGSLELNGGVMGGVNIEVNNLDIVIAPNLDINEDITKSVQLSLAQSTADLAQTIMLNQSEVLQMGSLEDTIELQDPTCIQPDVAIDTSNSDSSKSSASSASSPTIPKPSALGGVMARAVDMALSRLQVSIKNVNIKLLSELTDIVIKVEEATLSTVSGTRTTHLKGVSVITLRPACSPGDCEASNNESKDSTSGTKEEDSDTSSDDDNDEIDSSLMDSMVFTHEEASSIYMSATSQSFKPDRTEATPTLCDKDPNKSDNVIMYMDSLDVEFEGLSSISNVFVEIEKLTLSCSPLVPTVLSVINGISRSLKLKIYQKRKSTTSTYQSNPRFPQYASQSDDINETYDKDFEDEDDKHNGPDSSTSGDQQQLFNRLHIGEIILSVTSALNLSGEFLSPNNNLYLSVQNFNIKQKHDTLIYGGLETFQIIKTTDGKAENVLEFEQSVSEDGEPPKADIRFEMFSKISSDFKINEFTALISKPGKVNLDSYSLGHISELVDSFQIINSHLTGLFANYENYKRLSNNDIKPNVKKNKIDNHLVLQTAHMTMHLDLSSDCRICVQILPIFVNSLNNEMKCQRVIVEHHRDGGVDKIASISNIFLSTKAQDFKTFISHNHLFSRDINVISSTNVRVSKINVDLSFTLLKHIILSFGTFNGNLKSIPKRYNLVSMNSGSVYNPKKLKKRVNVTTTSTKNTAEFNVTFEEANFSLNEINKQFGSLLGRAVNISLFEFNGEHNFVLKGVKLNRVSGDLNEKIFYNYEERSLTDISEPLVLGQLKKNGSTELKCQRFVIEFYAHWQKLFENPNEEIKDDLNTFTKDTTEELKKTDVRIQLKDCFFGVTPNTLICKSYLNASRVNCDLMLGGEQLYIKTTVRELSLLLIDDLKELRSVSINKKYRYSVNPLDFFLKRGFLNIGNIANLHIGITYNFNIEKLLEKSSNKNIYNKLSALDIKVNLDECILETCGDSFYTFIQLINDLKIPLVLKNEEKFKVNLEHEINLLEGIDELERPNPSKIDSSIEDQHTDNDKDFEIGIDNLSVDNNYFSKNKSSQKQTVDPVSISVNVGKANLYMYDGYDWKETRKVIKGVVKKVEKESSEAGEDHDSNDETVDDHLEIIQETLFQSIHVTLPKGIDPSQLTQNINKQVTENADDGNTDGTGYKNLKLKRSNRYKMLIELKSIDVIVNVFTLRSPDEEPIPVHKEYEVLNEIELVVDLVTIYDNLLNSTWNKYLSYMNSIGEKEIGKNMIKFNLTTIRDPVSLNFNESILRISILPLRLFIDQDTNEFLVRFFNFNDKRFKLEKLEEDIYVKKIEIRNDIKIKVDYKPKKLNLIGLKNGEFNELLNLIHINGLTINLNHIKLYGIKGGDQIFARLFEYWLPNIQQTQLVNLFNGVEIFKPFFSISESLKNVVLLPITDYHDLNNQKFLKKLNKNGKEFFKITSYELLKLGYRLTNGTQNLLEHGEEILGGTGSKLRNHKVRQRKTSAGDTHLKFDNADIISEDETEEEAGLLENSIRLNKNTKRLESRNIYHNPHTKKYSEIEEEADDTGDSSEEEIEETKLVSLYSNQPKNFKQGIQLSFNSINKNYNLTKDEFLKLIERINESETYEDSLKIILKKSPLLLLRPMIGTTEMISKTLIGLSNEISSTEHLESKDKYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2K1</accession>
    <name>G3B2K1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF676-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_134010</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685502.1">
        <property type="nucleotide sequence ID" value="XM_006685439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2K1"/>
    <dbReference type="GeneID" id="18249756"/>
    <dbReference type="KEGG" id="cten:18249756"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027968_1_1_1"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="4"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="453" mass="51228" checksum="7375D1410BA42A81" modified="2011-11-16" version="1">MVEYHLVVLVHGLWGTSSHMAYVKSQIEQEAKSRATKEKIVCYITGSHSGFLTHDGIDVNGKRICDEILAKTQDLTVDKDKVTKFSIVGYSLGGLISRYAVGYLYSIGFFDNIQPINFTSFCTPHVGALNPGTSWGTRIYNYISPYVLAHTGFQLFLGDRKKDKLPLLVWMSDHRSAFFKALSSFNNLVLYANVINDKRTAWYTAAISSRDPFKSMINENASAYVLEFVDGYAPNVVDISKPLEFKSELNDNVQPPIVKRGKRSLWRKFNWLKLIYAVVVFPLWILYALGLAGVQAFRNHRRVGAFFKDRANSLVHLYEGTKSDTDSDDWTLESFEKGVSQRMEDQTDTFVESVFTAMNGDSYKNYQASTGSTSGETGSLVNLSGKEQDFKLGLNEDQVTIINNLNKLNWNKFPVLIRKTKQTHRAAVYRTDDPAFSEGKVVVQQFAQQAFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2R4</accession>
    <name>G3B2R4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Opaque-phase-specific protein OP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113522</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685546.1">
        <property type="nucleotide sequence ID" value="XM_006685483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2R4"/>
    <dbReference type="GeneID" id="18247003"/>
    <dbReference type="KEGG" id="cten:18247003"/>
    <dbReference type="eggNOG" id="ENOG502RAFC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061591_0_0_1"/>
    <dbReference type="OrthoDB" id="4017194at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442816" description="Opaque-phase-specific protein OP4" evidence="1">
        <location>
            <begin position="21"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34857" checksum="B657775122E5D04F" modified="2011-11-16" version="1">MRLFTFLFALILACGISVQAAPTTVDSGLSVREITMVQESVANINDYVKKRDGLAAEEKSKRESQIVTDVLTAIKDTNLAVPILEYVINDSTLEPIAVNTISYLIKNDYINIDTLLKALNDSGLAVSVIQDLISDCNFYAEIYSLALGYISDLADKIGDYIKGLFRREYMMVEITPKMAPLQRRASEEEILTSLMESLKDSGLANQVVEALVVDPAFYSFGADLIKKLIEDNDISLSSLVADLLDSGLIPSLIKAFLNLGTFDTIITNALAAAFGKCDGSSVTSAITSATTVASITTTPISDIPLPTGSTGVCRKKKRSYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2X4</accession>
    <name>G3B2X4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF689-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_113559</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2X4"/>
    <dbReference type="STRING" id="590646.G3B2X4"/>
    <dbReference type="GeneID" id="18247020"/>
    <dbReference type="KEGG" id="cten:18247020"/>
    <dbReference type="eggNOG" id="KOG4020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067152_0_0_1"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="210"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="9">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="9">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="9">
        <location>
            <begin position="295"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="9">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="332" mass="36766" checksum="CDF6C8E05016E6FE" modified="2011-11-16" version="1">MPGNVLLLIHPTVVTNESLVVQTKQSLADYRITQHIIDRVANNKVEITDKFDIIYYLNPNTGTDERGLPDAVISKFFGLLNEEGGEVVGDLPQDQALDVLMNGFMIENGKWVKPKPVKMAVMSLKKKPEKSEGKSLDSKLNKFKKLGAVSPVPSVGLTDTSANSSDEEEESNKRKLEKTKLTYFSDSDEDDEEIDENELVEASSPNYNLIVPRKCDTSGKKRRKACKDCTCGLKEQEEMELQNQSLLQTSLLSKMVRSATEEAMKIEEKLKNKVQFTETDMSEIDFTIKGKTGGCGSCSLGDAFRCDGCPFLGMPPFKPGEAITIDGFGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B355</accession>
    <name>G3B355_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_98074</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B355"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_2_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="47"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="537" mass="60149" checksum="D2F846DF6907355A" modified="2011-11-16" version="1">MSSTNYRGVLDVEATKSDEVAKSFKRDLERSVTEDLNRSLSTRLINMIAMAGIIGTGLFLGTGKTLAAAGPLSMLLCYAIIGGIVYLTMLSLGEMATLIPVSGSFTTYAKRFGSESFGFAILANYWFNDAISVASDLTALQIVMEYWTDFHAWIVALIFWVFLLFLNVFHVRFYGETEYWLATLKLVTIIIFFIVSIIVNAGKNPQHEYIGFKYWSLGDAPFVNGFRGFASCFVTASFAFGGVESIMISGGELKNPVRSTPKIVKIVWIRIFVFYVLAVFFIGMNVPYNYPSLSTGGIITSPFTIVFQMAGAKAAGSFMNAVIMTSVISAGNHALFAGSRLAFTLGTQGYFPKFITRTNRWKIPYVAVLLTWIAGGLAFGASFIGAGTLWTWLQCIVGVSNQFAWLCIGITSIRFRQGLAKQNKTHLLKFKNWTHPWGPWVVVVLVTFIIFVQGWSAFAPWDVSAFFQSYLEVGVFPFTFIVWWVIRKGKDRFVKSKDMDFETDQYVETQEEKEQNAYADSLTGWAKFKYNFVDNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B391</accession>
    <name>G3B391_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114141</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B391"/>
    <dbReference type="HOGENOM" id="CLU_3014003_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="56" mass="6662" checksum="96FCEDB2E917F8B7" modified="2011-11-16" version="1">MSFRTRITQLFKSNNTSDRKDRYPGKDHEIESLKRTPKPMEKKGFSSSTQEKMRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3B1</accession>
    <name>G3B3B1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_105339</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3B1"/>
    <dbReference type="STRING" id="590646.G3B3B1"/>
    <dbReference type="GeneID" id="18245802"/>
    <dbReference type="KEGG" id="cten:18245802"/>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_1"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030312">
        <property type="term" value="C:external encapsulating structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="335" mass="35713" checksum="7854E76F9574BA30" modified="2011-11-16" version="1">MAITVGINGFGRIGRLVLRVALSRKDITVVAVNDPFIAPEYAAYMFKYDSTHGRFDGEVTSEGSDLVIDGHKIAVFQERDPAAIPWGKAGVDYVIESTGVFTAIDGAQKHIDGGAKKVIITAPSSDAPMFVVGVNEDKYTPDLKIVSNASCTTNCLAPLAKVINDKFGIEEGLMTTVHSITATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVIPELNGKLTGMSLRVPTTDVSVVDLTVRLKTPATYEEIAKAVKDSSEGELKGILGYTEDAVVSTDFLGSTYSSIFDEKAGILLSPTFVKLISWYDNEFGYSTRVVDLLEHVAKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3E3</accession>
    <name>G3B3E3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA dependent ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_122352</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3E3"/>
    <dbReference type="STRING" id="590646.G3B3E3"/>
    <dbReference type="eggNOG" id="KOG0387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_7_0_1"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000039">
        <property type="entry name" value="DNA repair protein Rhp26/Rad26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="277"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="611"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="895"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1010" mass="116137" checksum="C21CFE47B616C17C" modified="2011-11-16" version="1">MSELESLGVQIVDQDDLETSITKKANEVLLAKDKQLEQKRLEKTMADAEKVHKKIGILERRLADPRTKISHRKQIRQEIDWFTLNELVPLQEDLKEIEGRLAESSKQLEEMETNITKPLDNDRLPDETERDYLVRIGKITAFGNQTAFEEDGGERSHVHLRQPGVGPADLIDDTDFTYKDEEIEAIEEDEIHPTAEMEEKNIDDGDERIYKRRYAAWVARRSAMRAAAGVESESDSPEWTKPHPTIPDSKLDDRFKLPGDIHPSLFDYQKTCVQWLWELYNQKTGGIIGDEMGLGKTIQVISFIAGLHYSGLLEKPVLIVVPATVLNQWVNEFHKWWPALRCVILHSIGSGMGQKIDENKLEQFLQQEEGATGKVFKGVRTQINAQQVVNSVMESGHVLITTYVGLRIYSKHLLTKSWGYCVLDEGHKIRNPNSEISLLCKRVKTANRIILSGTPIQNNLIELWSLFDFVFPGRLGTLPVFEQQFSLPINMGGYANASNLQVQTSYKCATILRDLISPYLLRRLKHDVARDLPKKEEMVLFVKLTHYQQQMYESFLESEDLRAIMKGKRNMLMGVDVLRKICNHPDLVNGNKSSEDYGNSKRSGKMEVTRKLIQLWALHNHKMLIFCQTRQMLDILERFLHRITKIDGNNMETGEPFEYLRMDGTTPIGKRQYLVDRFNTDPKISVFLLTTKVGGLGINLTGADRIIIYDPDWNPSTDMQARERAWRLGQKRDIVIYRLMITGSIEEKIYHRQIFKTFLTNKILKDPKQRRFFKMNDLHDLFSLGDQDDSEQTSNSSRSVIKKQAKTDDDFVKVAKIMGVSRLDSFEEGEHKDDEEQIMEGIFQNPNVHSRVQHDDVLDDKNNDGVEKEVNKIVDQSVKMLNESRKATRRNRVGVPTWTGKFGTAGKSKRGPESPRAPKALSSSTILENIKKKKKPDMVSERPDLLAELVEVLERNGRMSSNKILIALKNRVDVKNTRDILLVKSMLRKICHWNAVDKVWELMDEYVSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Q3</accession>
    <name>G3B3Q3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114276</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Q3"/>
    <dbReference type="HOGENOM" id="CLU_199937_0_0_1"/>
    <dbReference type="OrthoDB" id="4025683at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="66" mass="7443" checksum="B5A4C87E9B1CA0C9" modified="2011-11-16" version="1">MSLIKLNKKKSSLSTSSASSNSSGECYYAPHTNSFAKFDEKKDYFKRCNKKCEKKCPSSVSFCLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3R7</accession>
    <name>G3B3R7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_134298</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3R7"/>
    <dbReference type="HOGENOM" id="CLU_2037759_0_0_1"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="121" mass="13394" checksum="4C8203D699D72160" modified="2011-11-16" version="1" fragment="single">MFKKMDIPITAEKVRTSGQRLTGDCGPLKRSADKEGMAGAIFHGVGEGRICFMEAAAIAKRKDLEVKPLTKEEVFEVAGPWFGMIIVVDNHVSNKFTIETLGWKPIGPISIMHITKNHWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3T2</accession>
    <name>G3B3T2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_113763</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3T2"/>
    <dbReference type="STRING" id="590646.G3B3T2"/>
    <dbReference type="GeneID" id="18247108"/>
    <dbReference type="KEGG" id="cten:18247108"/>
    <dbReference type="eggNOG" id="ENOG502SG70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169147_2_1_1"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="61" mass="7101" checksum="FD7A406A64871C75" modified="2011-11-16" version="1">MAPDPQRIIKLQQRYQTTHKPLWLRGSNSRMLVYPYYALFTVGTVVSLYYSVRGVLGIKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Z4</accession>
    <name>G3B3Z4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_113931</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Z4"/>
    <dbReference type="STRING" id="590646.G3B3Z4"/>
    <dbReference type="MEROPS" id="M67.973"/>
    <dbReference type="eggNOG" id="KOG1556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="13"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="309" mass="34692" checksum="415C6DD89BAA0B25" modified="2011-11-16" version="1">MSTNESIFLNKTVTVSPLVLLSVVDHFNRVAQDSNKRVVGVLLGDNSSDTIRATNSYAIPFEEDDKNPGVWFLDHNFIESMGEMYKKINAKERLIGWYHSGPKLKPSDLKINDVFKKYTTNPLLLIVDVQPRESIGIPTDAYYAVDDIKNDGSAAERTFIHVPSIIEAEEAEEIGVEHLLRDIRDQAAGSLSLKVTQNYQSLLGLHQKLADISKYLDKVYKQSLPINHTILGKLQNVFNLLPNLNEGSMMEAGNDPKNSTNPLNTAFTVKTNDQLMMVYISTLVRSIIAFHDLIENKLENKMLNEGKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B407</accession>
    <name>G3B407_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_97928</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686220.1">
        <property type="nucleotide sequence ID" value="XM_006686157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B407"/>
    <dbReference type="STRING" id="590646.G3B407"/>
    <dbReference type="GeneID" id="18250726"/>
    <dbReference type="KEGG" id="cten:18250726"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_0_1"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF68">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="318" mass="35030" checksum="C51219F7C97688FC" modified="2011-11-16" version="1">MTASTFETPIGKGIYTPVPTFFTGENYELDLESQIAHAKFLYSSGINGVVTGGSMGESIHLTRQERLEIVKAIRSAVPSDEFKIISGMPYTNIPDTIAEIKALKDAGANYTILLTPGYYGNSLTTQQGIIDYFTLVGDKSALPIVIYHYPGVSNGTEINPETFEVLSKHPSIVGVKLTHFNMDKYVLLTGRVEENKANNFRPFTGLGQILVPSLAIGAFGAIDGLSGVFPKSMLKLFELFNNKQYEEAQKLQFLVTRANQMVFSLNLIGVKHALNVIHGFGDSNVSGRPPLNHQVDLKVWNKYEDDIKKLGEFEKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4K2</accession>
    <name>G3B4K2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_105617</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4K2"/>
    <dbReference type="STRING" id="590646.G3B4K2"/>
    <dbReference type="GeneID" id="18245824"/>
    <dbReference type="KEGG" id="cten:18245824"/>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006447_1_0_1"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="362"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="454"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV63966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="864" mass="96149" checksum="D9E1D3F0EB010859" modified="2011-11-16" version="1">MSASVISTDSRRSTGQPERIGNYQLGKEIGKGSFATVYKCINLKTNQAVAIKSVVRSKLKSKKLLENLEIEISILKSMKHPHIVGLLDYEQSSSHFHLVMDYCSMGDLSYFIRKRNQLIKTHPVISSLLDRYPSPEGSHGLNQVLVIHFLKQLSSALSFLRDKSLVHRDIKPQNLLLCPPSHSKEDFEANHFVGLWELPILKIADFGFARFLPSTSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVLYEMTVGKPPFKAANHIELLKNIEKSNDRIKFPSSSKVPDSLKKLVRSLLKYNPTERISFNEFFNDQLIVDELDSVDKPLETSQLDENLFISEYISPIPKITNKIEPLTKLSSHEDKVNPHELRNTTASSKENRDEEIKKIINKNSPGPEPMSESMRRNAGSNKFHDSLIKNDSALLEKDYVVVEKRAVEVNAIADELAQAGSGAVAIRRSSSTSSGGSGENNSLKYASPHFKKYSTRSNSGTSQRRPSLSDRRISISISPSNALSKAIGLASNRLFGYNNQISEEANRKILLDGAASGFGESSAFFTSPNFTNQLLSHKFNLPTSSSLQAQGQGISQIQSLSADEVVLLRLESLATKAHAINLFADVKFTQLIPSPPSNDDDLDDDLLHQNDILPPKMIKTISEEGVVLYVKTLSLLAKGMTIASEWWYSQVEVERSNSDSQINTRSHGSSPSPTPSLNSNINISVRINELVQWIREKFNESLEKAEFIKLRLQEVDSILESESGEQGSDSNLTSMVSNLSVSGNKAVAEKLIFDRALEMSRNAAVNELVKEDLKGCELAYSTAIWMLEALLDDDLESSNKLDTEDKQMIEKFVVSIGNRLSVLKRKLDFAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4N6</accession>
    <name>G3B4N6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_105038</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4N6"/>
    <dbReference type="STRING" id="590646.G3B4N6"/>
    <dbReference type="eggNOG" id="ENOG502QRAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013663_2_0_1"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000328">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="336"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="465" mass="53557" checksum="09476EAF3E97AA36" modified="2011-11-16" version="1" fragment="single">MVTKSDHSNPLAVTIPYQFTSADDYPTEVLANRFQAWRYIIKDLVSYLREYASVQEEIVRQQIRLQQAVAHRSGPTSSNKEVDISEINRYFLPIGNGSIQDLPTILTKYHQQNVATTNKTLKEITTVIVPKLEELRKDLLMKIKEIKNLQNDFKNNLSKEVNETKNLLNQYYQAVDISSKLEHGSVHHSGDAAESFKYDPYLVKIKLDRQLKKQLQEENYLHQAYENLQESGRKLESIIVIELQNYWGNFLNMLSAEHASFSNFLLPNLNNGFLAKESTFEWDSFIAKNLPSPSISVNAVGNSNSSIKNGTFIDLNFHSRKFSDLTINNYSSPLNMSVREGYLERKSKFLKSYSRGWYVLTCNFIHEFKTSDRKKDQTPVTSISLDNFQVNDHTKNNGKSDNSYKFILSSKPNGIIHRSQTWAFKTDSYENMIGWYNDINNLVSLPNAAARARFLSKRLNLNNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5I4</accession>
    <name>G3B5I4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_98388</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5I4"/>
    <dbReference type="STRING" id="590646.G3B5I4"/>
    <dbReference type="GeneID" id="18250770"/>
    <dbReference type="KEGG" id="cten:18250770"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001499_4_0_1"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05500">
        <property type="entry name" value="Bromo_BDF1_2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05499">
        <property type="entry name" value="Bromo_BDF1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000003">
        <property type="entry name" value="Bromodomain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="199"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="383"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="503" mass="58101" checksum="1B52D167553AD424" modified="2011-11-16" version="1">MVPAPTPQPEPDMNDLPDNPMPKHQAKFALNTIKNVKRLKDAGPFLKPVDIIKLNIPFYYNFVPKPMDLSTIEKKLTVSAYEVPEQFIDDFNLMVSNCIKFNGENSPIAKMGKNIQAYFEKHMLNFPPKEANESELSTASKRRIESQSSVPSIASNRPKRNIHPPKPKELPYDNRPRKKKFAADLRFCNQILKDLISKKHFSYNFPFLQPVDAVALNIPNYSDIIKQPMDLSTIQSKLANNQYENGDEFESDVTLMFENCYKFNPEGTDVSMMGHKLQDIFQKKWINRPIPKDTPQNSDNEDYSDDEFSDDNSDVDESVLSNIPAIKFLEDQLIRMTQELDKLKKDHLLKIKQQREQRRKSRASGKNRKRSGSMAHSTGGKSKKIKLIPQIQVTYEMKKQVSEQVPNLPDKKLQEFIKIIKDDVDLNDEEEVELDMDQLEDKTILKLYNFLFDKKPAKAKKMELTTNYDKLTKLKNQLSLFDEGMRAESSDDDDMSSESSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Z1</accession>
    <name>G3B5Z1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-protein ligase E3A N-terminal zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114635</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Z1"/>
    <dbReference type="STRING" id="590646.G3B5Z1"/>
    <dbReference type="eggNOG" id="KOG1816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1524948_0_0_1"/>
    <dbReference type="OrthoDB" id="193703at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20410" checksum="9C2012CFD584F05D" modified="2011-11-16" version="1">MHQLDTSAKVENFKLNFRKCTNENCINASSQDNSLGLCGSCYGPLYSQLYDPENVKLQSRIERRYVLQLNKGCEFTNCINSECKRNTIEPQSLKLIMKYVNERLMSYISTPALPVNKLKPVHPNKFWFCVTDSMNLKMDLFRAFADNYDPNVVIQGIRKIHTPTHELLQSWLKSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6F5</accession>
    <name>G3B6F5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_123756</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6F5"/>
    <dbReference type="STRING" id="590646.G3B6F5"/>
    <dbReference type="GeneID" id="18248977"/>
    <dbReference type="KEGG" id="cten:18248977"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="343" mass="38130" checksum="D325A1F1680BD49E" modified="2011-11-16" version="1">MEYVVIGSGIIGLYTALNLLERFPHKASSILVVAEFLPGDESNRFTSPYAGGNFSCISGSDSATLEHDRYTYTNLKRVCDLLGGPECGLDYCYSTEYFDEMPSGPKIKSIASYLDEYRVLAPHELKGAAFGIRFRSFSFNCPVFLVNLKKYLQTKGVQFKRQKLERLEDAFGDGVEVVFNCTGLGAFSLKGVDDKAVYPVRGQVLLVKAPHITENTMRWGKDYATYLIKRPYSNDQLILGGYIHKGNWSTDVLSEQTRDILERTSELIPELFSKNPRGPRADDLEILRGAAGLRPGRDGGVRIEREKVYGKTVIHNYGAGGYGFQAGLGMGRDAVALLRESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6I6</accession>
    <name>G3B6I6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94224</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6I6"/>
    <dbReference type="GeneID" id="18250373"/>
    <dbReference type="KEGG" id="cten:18250373"/>
    <dbReference type="HOGENOM" id="CLU_624024_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="439" mass="49916" checksum="60615931A78C43C8" modified="2011-11-16" version="1">MGNKANKKKTKEDTRILGPRHITSPSDTVVKRMTNRPQYRSNYAGFPLSFQVPSAPSDQSVSNLLNNVSHLFTKPMVYIDRSMGSLCPRFVSPSTLEAKALMKAPGETTRFKGMLGTTVKELDYTIEEWLGLLGVGYDQLINTMKFNMRLYNSIKEPDEILRCPVKDDGTNVEILHAHRRPATSLKRLGNEQLEDLCKKYGIRVFGIGKAKRTIMLTQLDLVFNKPYSAEDSFPIFEFMKGYTGGHPDISVIKHIIGMFPNMKEFRSKLDDMSHQLGVLKLDGSGNVLVCEVNWLQNILDKQLVDLDSMENKLEKFNWMFKGILDKFQGSFKREINLVKTEIELIVSSLDSTRSHIYRLKSQIVELRNKAGRYKVFVQGKKKAKKAVSKKPNLPRTIGDLRAATQASLAEIVEYYGLSSSSRDRSCLFQQILEFLHISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6V9</accession>
    <name>G3B6V9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_93806</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6V9"/>
    <dbReference type="STRING" id="590646.G3B6V9"/>
    <dbReference type="GeneID" id="18250329"/>
    <dbReference type="KEGG" id="cten:18250329"/>
    <dbReference type="eggNOG" id="KOG3409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_0_0_1"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048626">
        <property type="entry name" value="CSL4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21551">
        <property type="entry name" value="CSL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component CSL4 N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="98"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="273" mass="28852" checksum="0EA35AB9344F4CDC" modified="2011-11-16" version="1">MESILGHKVVPGQYITPLYKTHGDGVLSFISGKGTTVSQIEHNEKVVPIIVSTVVGILVSQPDASDENKITVSVLSSKYTATGANPDTIDISPVTNNLPKENDIVVVRVTKLNVKQAYCEILSVESSGNVIEDSGLGVNGDIAHQSLGAGGGAQALNNHSTIASSLTAGINAMAGELGESFKGVIRSQDVRSTDRDKVKIIESFKPGDIVRALIISLGDGSNYYLSTARNDLGVIYAKSENGAGDSMFPIDWEHMVCPKTGVVEKRKCAKPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6X4</accession>
    <name>G3B6X4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_130589</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686835.1">
        <property type="nucleotide sequence ID" value="XM_006686772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6X4"/>
    <dbReference type="STRING" id="590646.G3B6X4"/>
    <dbReference type="GeneID" id="18249460"/>
    <dbReference type="KEGG" id="cten:18249460"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_9_2_1"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="228"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="572" mass="63737" checksum="B175385BFCA11E65" modified="2011-11-16" version="1">MNKSIYELATIASAAATAAKGSIRIVCADTSRVLNSDIVKCVTGKPLEYVVNPTSSGANASRSMYKDLQAKSLANRQSHRNYCTKPSKRSQNYSTNALDGQINPSLDPLNEEKIATKPKVVGSKPEKSALESSEVPSSRLARMFHYGSLAAGMGLGMAQHGIKHYARTDRTGPSEGLSFKSLLLNPQNIERLAKKFSQMRGAALKIGQLLSFQDSAVIPKEIQAILLKVQNSAHYMPYSQLNRVMTEDLGANWRSNHFTSFDDIPIAAASIGQVHNAVTNDLSKVVVKVQYPGVVNSIDSDLNNILMLLTASSLLPPGLFLDKTIANARVELKWECDYIREAQNLIRFEDMVKDYPEFKVPKVYHKLCGTHVLTMEKMEGTEVIKGNWDQETRNWIATNIMKLCLLEIKKFKFMQTDPNWANFLFNDKTHQIELLDFGAARDFGDEFVENYVAVLRAAIRKDRQAIEDISVKLGYLTGLESQRMVDAHVDSVLVLGEPFSPQNNGGKTFDFRNQTVTDRVRGNISVMLSERLTPPPEETYSLHRKLSGVFLLCSRLNAQVPCEQLFADIIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Y3</accession>
    <name>G3B6Y3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114355</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EGV63529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
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    </dbReference>
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        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="368" mass="42093" checksum="9C5B3D076BB565FB" modified="2011-11-16" version="1">MAPKKANDKNKAKAKSKSSEDKTFGMKNKNKSKKVQTQIAQMKAGVDGGLEKKREADAKRRAEEKKAAEQAKKEAAALFGIQQAKVPFGVDPKSVLCEFFKKGVCAKGNKCKFSHDLNVGRKDAKKDLYTDARAEKEEDTMDNWDEEKLRSVIMSKHGNLKTTTDKVCKYFIEAVENAKYGWFWVCPNGGNECMYRHSLPPGFVLKTKEQKKLERLAAESAPKITLEDFIELERGKLDRSKFIPITLDSFQVWKAKKRDQQAREERKEREKRKRTGREIVMDLFADKYYSEEDNKDEWDLSEFRESLPEVESDVKDYGNAAEEHDDIDNDEETDTNGTLINGDVNDTTKYNNNGNTQKIVESKVEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Z6</accession>
    <name>G3B6Z6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114370</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Z6"/>
    <dbReference type="STRING" id="590646.G3B6Z6"/>
    <dbReference type="GeneID" id="18247393"/>
    <dbReference type="KEGG" id="cten:18247393"/>
    <dbReference type="eggNOG" id="KOG1493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115512_0_0_1"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="136" mass="15650" checksum="5D5350A999425599" modified="2011-11-16" version="1">MKVQVLEWNAVASWHWDLKVDDSGVADELCGICRVPFDGTCPSCKYPGTDCPLILGDGCTHNFHLHCILKWLEQDTSKGLCPMCRQVFVYKRIKNMGTSEELHNLQVLIEGHKAMRERENEENEFDSFEDDVRMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B728</accession>
    <name>G3B728_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palF/RIM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_106660</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B728"/>
    <dbReference type="STRING" id="590646.G3B728"/>
    <dbReference type="eggNOG" id="ENOG502QTQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006001_0_0_1"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="321"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="501"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="510"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="695" mass="76608" checksum="843B40B7729D8728" modified="2011-11-16" version="1">MRKAVSRIIPGRSKSFLDGPSTGPAPASGAGPVQTPNTASSSPFRIDFNSVSDFYIVLDKPHNSWLPGDEVSGQIILITKKNLANIVITLSLVGYVKINGLSHSKLRPVKHSLFNHTIKIYGDDLQPTERSDGLSSGLYKGEHRFPFIVKLPNKRIYTSIDFGKGSITYLLKATMSDSNMVYAQSNTPGDSNPSSPGLLAKTKNLKILNNSNYSSEKLINLINPIDVSTLLPPKTKRLIIKDPRYNRRLSRTQSSNSTINTFNTFGTFSSNNSDPNENTNSNSNSPRDQEMGESLENQPDDHNETPTTPHAPSNSVDYASKPNTIKVSLAIPEKGYLRGELIPVKLNINHLRKVQDVNGIIITFVRVCRLESGPDGIYDSFRKDLGQKVIPIYVDPINFKAEISTNIRVPADCFPTISGCPLVSFQYFVEVLINLSGKSVSLVDNEQTKSSVVSETGRQSPIYSSTVSDFNHKATSSFINTDKFKHSKKFLQLTSEVVIGTHRSQKDSDSSASVSNPLSSDIPLETPPSRGSSLRSESSPIVPAAQSHAAQIIPQPLFNVIPEAMEINHFNGRAPDYNEIHNESGLLPFPEQPAMSEKDQMRAHERSLLPSEPFLSVNDVESRESVSPIMENAQLLEPSTPPQETNGGTDFNFFSNEQSPNNNEQEDQYSQIDYVPNYERSNNDPLVEGNSTSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B730</accession>
    <name>G3B730_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="4">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_106646</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="4"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B730"/>
    <dbReference type="STRING" id="590646.G3B730"/>
    <dbReference type="GeneID" id="18245905"/>
    <dbReference type="KEGG" id="cten:18245905"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_1"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF2">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="52"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="590" mass="65516" checksum="7E3D6549CC28342E" modified="2011-11-16" version="1">MFKATNILFQRAAPAAKKYANLLRDPSKKYSPFKTVHLPDRNWPNKTITKAPRWLSTDLRDGNQSLPDPMTVPEKKEYFKKLIEIGFKEIEVSFPSASQTDFDFTRYAVETAPDDVTIQVLTQSREHLIRRTVESVKGAKRACIHTYLATSDLFRDVVFNMSKDEAIAKAVEATKLVRSLTKDDPEMQDTLWTFEFSPECFSDTPTDFAVEICEAVKNAWEPTVEQPIIFNLPATVEVASPNVYADQIEYFCRNITEREKICVSVHPHNDRGCGVAATELGVMAGADRVEGCLFGNGERTGNVDLVTVALNLYTQGVAPELDFSDMESIIAVSERCNKIPVSARAPYSGSLVVSAFSGSHQDAIKKGFEKAAKRDSQKWAIPYLPLDPKDIGRNYEAVIRVNSQSGKGGAAWIILRSLGLDLPRQLQVEFSGAVQDTADLLGRELKSDEIVELFKERFMAERTSVLNLKEFDIFRNKDSDDSSREINASLDINGKTISVYGKGNGPISAFIDAISSRFGTYFEVIHYSEHNLGTGSQGKAATYIQLSYINSNGEKVKKWGCGVHSDVSEASVHAIISVVNSLIESKEIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B763</accession>
    <name>G3B763_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114424</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686903.1">
        <property type="nucleotide sequence ID" value="XM_006686840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B763"/>
    <dbReference type="STRING" id="590646.G3B763"/>
    <dbReference type="GeneID" id="18247420"/>
    <dbReference type="KEGG" id="cten:18247420"/>
    <dbReference type="eggNOG" id="ENOG502QZAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067849_0_0_1"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="351" mass="39688" checksum="5A12742F8F99FB1E" modified="2011-11-16" version="1">MTTVSRKELKQLLKSFHEALEYWAKSLETKKSMEEIKSAQVSDPLDELTKLSKLIKAHVTKVGIIFKPDILQKQVESSYNTLQKLSESNVLLISLAAQLDPNQLSRIFYDEIIDRIKQILLSNTYLVQQLMIIEKTIEANDDGEQVPVSPLEETDGRLVSVGKIWSCCDGLAKVVADGKIGVLNSKFRQSIDLIEDGLEDFAEWVENPEAFDDEDPFGFTDDEESDEDDGATPPETDENKQELKDYGKLWLARFKLVRLLLTSISKSLPSVTSGDTINIIYQAQKAIVSNVDKLIVDLMMSSRIDADTESYAGEITRNCRNLIKVVRDVNKSNEAKVKWCDTWDTKFNKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B773</accession>
    <name>G3B773_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115045</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688746.1">
        <property type="nucleotide sequence ID" value="XM_006688683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B773"/>
    <dbReference type="STRING" id="590646.G3B773"/>
    <dbReference type="GeneID" id="90981619"/>
    <dbReference type="KEGG" id="cten:90981619"/>
    <dbReference type="eggNOG" id="ENOG502RZDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1165700_0_0_1"/>
    <dbReference type="OrthoDB" id="4085867at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014841">
        <property type="entry name" value="Rad33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08730">
        <property type="entry name" value="Rad33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="228" mass="25966" checksum="7E7E6DD827EE4206" modified="2011-11-16" version="1">MAKRRGTEVSTKFLSINPQYEEEVLEVYAILTEEVEDLQLKQLRTVFKRLQIPKCFTADILQSIDHFYESNGTLIKHRTPKSDIVLHMVTTFTISSRLVNDSDIIDIVDVDKLISYTSKLLYYRDNYTHIKNTWRLFVETVLGSAPSVSELLEFKLNLVDLKKIKSVLGLDGSGKDTLSDVLLIDMLSCCSSDESGTIYNFDFSRATHGLFINIKDFACILGNLGEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B784</accession>
    <name>G3B784_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115052</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B784"/>
    <dbReference type="STRING" id="590646.G3B784"/>
    <dbReference type="eggNOG" id="ENOG502RZK4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053570_2_1_1"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="257" mass="29815" checksum="5DB84664A78CB922" modified="2011-11-16" version="1">MSLFAKTQTLINQLESTIDERKQLFSLKLEPSTNDNFDLINLLDKISKNLNYLQDDCKDSGNYQRLETTVDRFNSNIDSLSHDTSIQIDEYKFKIKTRREPVVKEAKSVRFQDDNDDNEENLRNELMGTRTFRPYRDVPDADSEFDDASETSQDSNLNNQQMFAQHQQQLLTQDDDLDVLHESVKIQKSMGLNINQELDEHLIILNDLENGVDVAHRRVRNTNNRLNEFRSKVQENGSLVTIIVLTVILILLLVVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7E1</accession>
    <name>G3B7E1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Multifunctional tryptophan biosynthesis protein</fullName>
            <ecNumber evidence="6">4.1.1.48</ecNumber>
            <ecNumber evidence="5">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_115713</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573</strain>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two components I and two components II.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="6"/>
    <dbReference type="EC" id="4.1.3.27" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7E1"/>
    <dbReference type="STRING" id="590646.G3B7E1"/>
    <dbReference type="MEROPS" id="C26.959"/>
    <dbReference type="GeneID" id="18247980"/>
    <dbReference type="KEGG" id="cten:18247980"/>
    <dbReference type="eggNOG" id="KOG0026">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039523_0_0_1"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="15">
        <location>
            <begin position="9"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="16">
        <location>
            <begin position="217"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV62832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="493" mass="55099" checksum="FA6B225AC81B3588" modified="2011-11-16" version="1">MTTDKKRVLMIDNYDSFTWNLYQYLNQSKYCDKVDVYRNDEITIEQIENDIKPDLLFISPGPGHPSTDAGISRAAIDYFKGKIPIVGVCMGLQCMFEVFGGSVTYAGEIVHGKTTTIHHDGKGMFTDIPQSVAVTRYHSLAGSLSSLPDCLEVTARTETSPQIIMGIRHKKYAIEGVQFHPESILTEEGHVMIDNLLKINGAYWADSQKIPVKENILNKIYDQRRKDYDEIAQLPGKSLEELQEYLDLGLAPKLINFYHRLNSTKENSRNIILSEFKRASPSKGVINIKANPVKQALTYASNGCSAISVLTEPNWFKGSIEDMALIRKSIDSVENRPAVLRKEFIFNQYQILEARLQGADSVLLIVKMLEPVLLAQLYDYSLELGMVPLVEINNDEELKTALTLGTKEPMVIGVNNRNLVSFDVDLNTTTNLLDSIRSNGRDILVLALSGITSVEDVVQYKKQGVDGYLIGESLMRAEESGHAAQFLADLCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7H7</accession>
    <name>G3B7H7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115743</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7H7"/>
    <dbReference type="STRING" id="590646.G3B7H7"/>
    <dbReference type="GeneID" id="18247996"/>
    <dbReference type="KEGG" id="cten:18247996"/>
    <dbReference type="eggNOG" id="KOG3295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075696_1_0_1"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="202" mass="23102" checksum="D13F40A9D4CD1CA7" modified="2011-11-16" version="1">MAIAKNLPILKNHFRKHWQERVKVHFDQAGKKAGRRTARLQKIAKESPKPVDSLKPVVRCPTVKYNRKLRAGRGFTLAEIKAVGLTPKYARTIGISVDHRRVNRSDEIYDLNVARLQEYKSKLVLFDKKTTKEEIAKFADVSIKSTFPIAQVPVETAPRAVEVPEQSAYRTLRLARSDKKYKGIREKRAKAKAEAEADKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7P1</accession>
    <name>G3B7P1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115749</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7P1"/>
    <dbReference type="STRING" id="590646.G3B7P1"/>
    <dbReference type="GeneID" id="18247999"/>
    <dbReference type="KEGG" id="cten:18247999"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020262_1_1_1"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="171"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="347" mass="39185" checksum="70654A943B700C6D" modified="2011-11-16" version="1">MLSALFCCSVDSKEDTDGNYNSKPSSNSKYSQSKIDNSKDLTHSNSNPNKRPKNKKEKMDKDDSSINETETIANTNEEPTATPLHPNQKHDSNGNSNITNSSSDTSEPPTVGSSSSHQQDKVIIAQAGSEDLVDLDLEDMDEDSMMDLTKFQVDQYRNPETGWLLGKKAPHFKNKKCLILDLDETLVHSSFKYLRTADFVIPVEIDNQIHHVYVIKRPGVDEFLEKVGQWYEVVVFTASVSKYGNPLLDKLDIHKSVHHRLFRDSCFNYENNFIKNLSQIGRPLGESIIIDNSPASYIFHPQHSVPISSWFSDTHDNELLDLLPFLHDLSEQNVDDVSLVLDVMLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7R4</accession>
    <name>G3B7R4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Patatin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_126019</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7R4"/>
    <dbReference type="STRING" id="590646.G3B7R4"/>
    <dbReference type="GeneID" id="18249144"/>
    <dbReference type="KEGG" id="cten:18249144"/>
    <dbReference type="eggNOG" id="KOG2214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009031_5_0_1"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07230">
        <property type="entry name" value="Pat_TGL4-5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000036">
        <property type="entry name" value="Patatin-like phospholipase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="216"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="247"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="638" mass="71967" checksum="F8C0E6860DD18CF7" modified="2011-11-16" version="1" fragment="single">MSSASNGYQLNSDISDLIEEIIEKFDRPPTYNSIFNKSGEYKTTTSAISGTILSYAQSIPILNKLFPITNEKQQLTNSLLEQQKLATTYSKWYDVSLQLDELMGNNAWKSNPESPYYDFELIHHNINEMRTARLNRDYKLLLYLIRTKWVRNFGNIGDVSLYKSSFVGTKKLIEDYITECKLSLDYLVNGSDVDLDDRYLLGMLIQTRKNIGRTALVLSGGSTFGMFHIGVLVSLLEVNLLPRIISGSSAGSIIASILCCHSYEENKIIIQSLSEREFEIFNSGLDEEGILHEKKNQFRTLLKSVGHFLKYGTVFEMGSLKKTIIGFVGDLTFREAYNRTGKILNITVSPASLHEQTRLLNYLTAPNCLIWSAVCASCSLPGFFPSTSIYEKNPRTNKIQKWNGDSSIKFVDGSVDNDLPIMKLSEMFNVDHIIAVQVNAHVVPFLKISVSNPGGYLEDDLTTKFKGILNNAYDFFTCELIHYFQIFNEMDIYKNLSTKLISLLSQSYSGDITILPNYKLSDFTKVFSNPTPQFIADFIIRGARSTWPKITLINNHCGVEFELDRAITLLRGRTISSNSNSTFGNSLIVNPINLVQCNNSPTTEEWNQLTTTKSLGSSSARWDPVTPDRKRVSSLMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7S2</accession>
    <name>G3B7S2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_99329</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7S2"/>
    <dbReference type="STRING" id="590646.G3B7S2"/>
    <dbReference type="GeneID" id="18250847"/>
    <dbReference type="KEGG" id="cten:18250847"/>
    <dbReference type="eggNOG" id="KOG2697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_0_0_1"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000002">
        <property type="entry name" value="Histidinol dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="20">
        <location>
            <begin position="204"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV62308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="849" mass="91815" checksum="2F17D9D4D824B772" modified="2011-11-16" version="1">MTFPVLPKVDSTTSTDINDYAFVGKVLVPFEGLQVSKFLLSTFPTQVDVLVDASDALISVDQAVEVLNSGVQTIFISDSQVEELIKTSGLPSYRFGIKTQEPEKFTDLDASLVVSSKVANLKAVNQDDNRSVYFDGVVDEASAIKLAQADYIPIISTKKLTKKSDTSNISVGRLLTSTLTTDRPDGLFTTLITSGAPSYTALGVVYSSEASILESIATGEGVYQSRKRREELWYKGKTSGATQRVISISKDCDSDVVKFVVEQRDGFGFCHKDKNYTCFNDGSLYSESTGKGLGRLDHTLVKRKEAAPEGSYTKRLFNDEELLVAKLKEELDELIEAGKANDKQEIAWEAADLIYFVMVWCVKNGVRLSDIEKNLDIKDLKVTRRKGDAKAAYLKKPEPKEEPKQELSYKLTTITAATTSPDLIQQALTRPNQKTSDIMKLVLPIIKNVQENGDKALLELTAKFDGVQLESPVLNAPFPPELMQISEDMKEAIDLSMKNIETFHAAQLPKEEVMSVETAPGVVCSRFAKPIENVGLYVPGGTAVLPSTAMMLGVPAKVAGCKNIVIASPPARATGKLTPEVVYVAHKLGASSILMAGGAQAVTAMAYGTDSVVKCDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVIADSNADPDFVASDLLSQAEHGVDSQVILIGVGLSTSDLAGIEEAVATQASVLPRREIVSKCLAHSYTLLVDTYEEAFKLSNDYAPEHLILQIEKAGSYVPDYVDNAGSVFVGKLSPESCGDYSSGTNHTLPTYGYARQYSGVNTATFQKFITSQEVSEEGLKSIGKAVMTIAAVEGLEAHRNAVHVRMEKLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7X9</accession>
    <name>G3B7X9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_115142</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7X9"/>
    <dbReference type="STRING" id="590646.G3B7X9"/>
    <dbReference type="MEROPS" id="C54.001"/>
    <dbReference type="GeneID" id="18247738"/>
    <dbReference type="KEGG" id="cten:18247738"/>
    <dbReference type="eggNOG" id="KOG2674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021259_5_2_1"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="71"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="408" mass="46115" checksum="BE480AF3EF3DB856" modified="2011-11-16" version="1">MASMSTKDIPEQHSLETPLEDAPPERSGLSFSFSELWQHIPRPTSNPGNETEVIVEKPPKIIMGQSYKVEDEFLLQVEALVWLTYRTGFEPIPKNPNGPHPLAFVQSMVFNKNPLSTNVHSFIDNENFTTDVGWGCMIRTSQSLLANTYKRMISEDAQQEIQLLDQFKDSEAAPFSLHNFIRVANESPLQVKPGQWFGPNAASLSIQRLCNLVNSKENFGLPGLSVLISENSDLYDDKVQEFLDKKKQSLLILLPIRLGIDKTNEFYYSSILQLLNCKQSVGIAGGKPSSSFYFFGYDNDELLYLDPHYPQGTNAGYNSYHTPRYQRLTISQLDPSMMIGILVDDLQDYNTFKAECLEKNNKIVHFAAKSAINEIQAPASEVNADFVDFVDDFDEDDIVEDEDLDRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8A7</accession>
    <name>G3B8A7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_107892</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687896.1">
        <property type="nucleotide sequence ID" value="XM_006687833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8A7"/>
    <dbReference type="STRING" id="590646.G3B8A7"/>
    <dbReference type="GeneID" id="18245989"/>
    <dbReference type="KEGG" id="cten:18245989"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="497" mass="57517" checksum="DFC405754BA20DA4" modified="2011-11-16" version="1">MFDSILLQLTAVLAVVLIAQQLYHRYLARKWACGDILKVDQDYFGIWQARKLFADRNDGVDLQEQRNRFNRYHTETFRETLIGRELYYTSNLENIKAIVNFQFNDFSIGYRYPAFKPLLGDGIFATEGHKWKVAKEVLRPQFVREQIRDLDHLEVHIKNMAAIINNTHGQVFDIQDLFLRLTLDASTDFLFGESVSSLTKSEYEMGKYTFESAFNKVQKYIFARSILQSLYWTYNPKDFRECLNVIHTFTDTFVQKALSLTPEELDAKSKKNYTFLYELVKITRHRKTVHDHLLNIMLAGRNTTSALISSLMLELARNPECYEKLKKDVFENFGDGSDLSCVTVESMKKCNYLRYCINEALRMYPSVPQNFRCAKTATTLPRGGGPDGQDKIFLKKGQAVFMSFYTLQRSELYYGKDANEFNPDRWATIKNPGAFMPFLSGPRICLGQQFAIAEASYTILRIAQMFPNIKSFETEYPPRISANATMKLRDGVMVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8E4</accession>
    <name>G3B8E4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_126227</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8E4"/>
    <dbReference type="STRING" id="590646.G3B8E4"/>
    <dbReference type="eggNOG" id="KOG1578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_3_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="256" mass="28664" checksum="F5A183DD8B32E161" modified="2011-11-16" version="1">MGRENILKYQLEHDHETDLPQTSSRKDLDVKIRNSHFPFTLSKDSTIQDYLSNNKFFVDSINHNHSPEVFALNGKGQQPHTLWIGCADSRAGEGCLSVLPGEIFTHRNIGNIVNSSDISSQGVIQFAIEVLKVRKIIVCGHTDCGGVWASMSNKKIGGVLDLWLNPIRHIRAQNRTLLNSIEDPKEKATKLSELNVISSVLALKRHPSASMALKNGEIEVWGMLYNVSTGHLQEVEVPADEFEDLFHVHDNEDLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8R3</accession>
    <name>G3B8R3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_108495</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688581.1">
        <property type="nucleotide sequence ID" value="XM_006688518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8R3"/>
    <dbReference type="STRING" id="590646.G3B8R3"/>
    <dbReference type="GeneID" id="18246033"/>
    <dbReference type="KEGG" id="cten:18246033"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442882" evidence="6">
        <location>
            <begin position="22"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="406"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="467" mass="52516" checksum="BCE4F65339452537" modified="2011-11-16" version="1">MVSLSKALFSSLLSLPLDVYRQVANPDLAATSQYNIVKYLSGAGPFLEFSGYGISTDLPDNCTLEQVQLLMRHGERFPGLSAGLGYEAIIDRLQSYNQTIVGPLAFLNDYEWFVPDQGLYEYETTPANSDSPYSGFETAWKAGATFRSKYNSLYNDSQILPVFAGASARVVQTADFFTRGFLGANFTKDYYVYNVISENATQGFNTLTPRWGCTNYNSSANSAFVKEFPTDYLDTIVDRLVDENDGLNLTTADIQSLIQICGYELNAKGASPFCELFTQDEYVTNSYQNDLSFYYSAGPGHNLTKYVGWVQLNASLALLKDDDNEQKIWLSFIHDTDIELFHSALGLFDTIEPLPNDQVRFTDTYHHIDPIPMGARVITEKFSYSNDGESYVRFIINNSVKPIKGCSSGPGFSCKLSDFEEYVEERFGDFDMEDVCAPNPDYPQDLTFYWDWQGNEAYNITAPRIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B908</accession>
    <name>G3B908_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_115896</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573</strain>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B908"/>
    <dbReference type="STRING" id="590646.G3B908"/>
    <dbReference type="GeneID" id="18248073"/>
    <dbReference type="KEGG" id="cten:18248073"/>
    <dbReference type="eggNOG" id="KOG0788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023050_0_1_1"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001355">
        <property type="entry name" value="S-AdenosylMet_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5013990382" description="S-adenosylmethionine decarboxylase beta chain" evidence="18">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013990381" description="S-adenosylmethionine decarboxylase alpha chain" evidence="18">
        <location>
            <begin position="90"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="14">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="14">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="14">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="14">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="17">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="16">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV62924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="428" mass="49060" checksum="425BAC74452769AD" modified="2011-11-16" version="1">MVAPAYTDDSYVDHELSANLDSTSAFEGPEKLLEVWVWPNEAEVKSHSNCEDGLRSIPLKNWVDILDLVNCKILSMKSSKYMDAYLLSESSLFVFSHKIILKTCGTTTTLFCIEKLFEDIRHYVAKKVNTKEIFKVFYSRRSFMFPERQQSVHKDWKKEVKLLNEYFINGKSYVVGDFASDDHWYLYTGGQKDDECKAPGSIRDQTFEVLMTDLDPGKAEQFVTSRKPGFESFVKNGFEEDDLGHEFGFKTIKSTKLNSIFNDYDQLNKQVGGGSAQHLPSPKEDGGFESAGQFLPFNFVHDAFSFTPCGFSSNSISSNNGSYYYTLHITPESGWSYASFETNFPFSSISNSSINIVDVLIKILKVFRPGRFSVTLINEIDTKGDETELSELFNCDRRLCDLNYKKNERVLYDLESNYKLLYLNFEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B921</accession>
    <name>G3B921_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_107757</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B921"/>
    <dbReference type="STRING" id="590646.G3B921"/>
    <dbReference type="GeneID" id="18245977"/>
    <dbReference type="KEGG" id="cten:18245977"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_0_1_1"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000011">
        <property type="entry name" value="SEC14 cytosolic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="97"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="300" mass="34404" checksum="8F9FC02247A03C64" modified="2011-11-16" version="1">MATEEEILASYPQVSAPTDQSGYTSNLTEEQEQVLKQLEAALKELGYTKRLDKASLLRFLRARKFDLEKTKQMFVSCEAWRKEFGTDTILTDFKYTEKPLVAKMYPQYYHKTDKDGRPVYYEELGKVYLPDMLKITSQDRMLKNLVWEYESFTNNRLPACSRKFGCLVETSCTILDLKGISISSAYQVVGYVKEASKIGQDYYPERMGKFYCINAPFGFSTAFKLFKAFLDPVTVSKIFILGSSYQKDLLKQIPPENLPKKYGGQSDVSEQELYLSDIGPWREAEYIGPEGEAPKSIDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3B948</accession>
    <name>G3B948_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_126477</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B948"/>
    <dbReference type="STRING" id="590646.G3B948"/>
    <dbReference type="eggNOG" id="KOG4269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398474_0_0_1"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="218"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="487"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="78113" checksum="372EFF9896F211AE" modified="2011-11-16" version="1">MSSPVVPYSQYSQVSPATGYSYRGGLDYESESIRTPITTDFTSHDSIYNIRSSNVMISNNSSYSVNRTMVNEDDGALFIKPEEFQTIALTVISTISNGNTQVQASTSSKRLDDIFITIAVNDRSTGKEMWRIKKSLNQLIAFDNEIRPTVEYFGLPVLPDKSLFFSTTPNKIDVRISGLQNYFNTLFVMPHIPHLILFRICKYLSLDFVNPLDEFKSGSRKEGYLVRKYKGLGTSWKVRWCQVDGPVLELYDQPGGSLLEQINLKHCQIGRQSNDSVAEDKGYRHAFLIMESHKSSKLSNSFPKHFFCAENDYERDEWVNALIDMSLVVDSNSTSTANSIKDDIAGYNVNFQTPRNYGSDYQDEPDYTNKTKSPVPSNVSYQTMDSLEKEKPTDKKGKKRSIFPFRTKGSNPNSSTSQLFDASNLVDSDLSNAIASSPNANSSFTSNSSHQNGTSATVVEDSSIQSYLDKMGLDEQVNKSIFGRELVQAYEISHHNFLGREVPSIIYRCIEFLLKTGAVYEEGIFRLSGSASTIRQLKEAFNKKFDLDLFENELKPDMHTVSGLLKTYLRELPSPIVSDKGYSDLRNIVMNNGNTAATSLKFKDYFNNLNNLDRVYYDTSYIVLKFLKEIINNKDSNKMNLRNVCIVFVPTLNISLDVMSLLLIDFNCIFEDGDPIPDNQREVLDLNIPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9D1</accession>
    <name>G3B9D1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115944</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9D1"/>
    <dbReference type="STRING" id="590646.G3B9D1"/>
    <dbReference type="eggNOG" id="KOG3176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071893_2_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="82"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="9">
        <location>
            <begin position="182"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="235" mass="27386" checksum="867362F0C96D4423" modified="2011-11-16" version="1">MEVDDILRNFDTEVGQRSQKPKVDLYTSLSRVMLNERMAPEILPYQKDLLDEVLSRITNQQQLLLDSHEYGDVNIDSGIITSDYKLQLMIMETDIERLSYLVRLYLRVRLSKLETFTIHYIRLTGERDDTKATLLSDEEQEYLTKYMGLLQSLYNNSILKKIPRELTYLDEVESDISMVTTPDVDEMVFIKVLRDETITIPLEDEDELQLEKDAVFVVKYGLISGYLNIGDVILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9M8</accession>
    <name>G3B9M8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115382</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688099.1">
        <property type="nucleotide sequence ID" value="XM_006688036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9M8"/>
    <dbReference type="STRING" id="590646.G3B9M8"/>
    <dbReference type="GeneID" id="18247842"/>
    <dbReference type="KEGG" id="cten:18247842"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1220085_0_0_1"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="240" mass="26052" checksum="360933A788E57D0E" modified="2011-11-16" version="1">MAYYYYKFEWPLEDSVESVQVTGNFDNWSRANPPLAKDSNGFAGIIKLPAKQKLIFKFVINGTEWKLGPHYKTASDESGIENNFIDEDELSLYEEFEKESTVEPESASESTESDSGGKEHEIHQVLTGASSFAAVSIPSNSSKFEDLAEADSPPVTPTETPVTGSDPRPTTSSAVTGGGTVMNLSDSNSTLNKPDELRIPGSYPISPVAKGGDVTNTPSNTSGRFKKDGLVSKFRGLFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9Q4</accession>
    <name>G3B9Q4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_131403</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B9Q4"/>
    <dbReference type="eggNOG" id="KOG1823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000327_0_0_1"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="830"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1618"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2204"/>
            <end position="2511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2481"/>
            <end position="2523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2493"/>
            <end position="2508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="2523" mass="289380" checksum="0D2A631984453509" modified="2011-11-16" version="1">MVAHTKADKSKHKVNNKTAKRKKLTQSSRKHAFKSFKDRVDSIKIEPNLNLSRRVYDDVEDTSSHFISTLHHWKEVNLSGNFTSFTDDIKSVCQSLPQVIYHQQSIFDSLYKHLEKYDAHSVQALLEVLSQFIHDLGSDFMVHYEKTLRLLTTIALDIKANDLQNNTNASNLLEWIFNCLTFIFKYLSRDLVQSFEPSFEILLPILCMNKQQYISRFCSEALSFIIKKMDSKQLSQVVRYLLVEKIDLIMENITFKDSSIVLFSEAITSSGESFHSKASIIYERLIETSFTNLNSNIIISGVLANLFQHGSQKSVEQFISITLKHMTYSLETSSHLSEENLTQIIEIFITLVFSESGKKVLAWEPIISMAYQISDKILEMNKDLNIDAFLFSLSTLTRNCDLLTINKSFRKLFAFLMKYQNGSRVIPFVDSTLKICEKKLLNLGLTTIFQEFINNSSTNESILRQLSLFLMKNPTFQVVIPEETCEYLTKSLDLKVSKHENLLNIYWKLNVVKFNVKNVKQLPLAEFVQSLKTGSLFIGDFIGILISFTEPTETFIDYLSSNFDSLKISSVFLDAFSKVVTESSHSMKKNKILEIIGSVADNFSKDDTTLRLSSVDFIIKILTVKDLECPEFICSIKVIETIPLTLGNARDIQLRIRMLVNQFNSLENKSDLDCKIISNYFFGILNNRFQPCWAAVFENLPRIVGVCEKYLWKLSYQFVTFDYLNQDTDYLVYGDDDMLVDDSIPETDLSFNDDRITSSFNSLLENSYRHFRSGFQVLISLSQSFSTNMVYEERMRALAIECWHKIPELAESNNQSVSGLILDRTCSQDWGMKDRNLLLTTFTKFKSLKTIKDADRLYQLLLNILTSQRLVSQKLALDVILNYKIHSLSNYRDNLKNLLDDTLFKDELTKFITNEQDSSIEAEDMDVLMPLILRILFGRVQGGAKSNSKASRKNAVINILPSLNQEHIIAFLKLGYDKIGFKDLNSISMDDFSNIKRINGFVALLYELYDVLGFNFANALSTSIDPLVYSISVAQLRINTAGEDNFEAEDEENINDDEGVQEDVNDSRNEIKSAKRIRQLGLRCLNTLFKNFGELYDWPKYFNSIYSNIIKPRLNNFDRENLQQPSSLTMMMVSWLKLPSISKFLMVDDLKPSRAIISLLENRKAKDPVVAVALGFAIDCLQSPFRETEDDSFITLLAILVESLLKNLPDIIGSTLDIEVINKSVTILLLLIDGDYIVDDSTRNSLIDSLCKVFNKPPNKVALDDREKILLSLSILINDYNGSLDDFFQYYKILSRSFRTYKEKSIRTNLVEVFKSLGSKFTDLIIVGELLDGMNSYAINSSSNRLGEPNYEAVLKAYKDINDTFYLTLSPVQWLPILYCALFFINDEEELIIRTNAGYVLNHFIDAYSSRQTIVEASELIELFKTIILPEIRDGLKLTVEAIQTEYINVLAYCVKNSKHFTDLDDMRVLLFEHDQEASFFANINHIQLHRRQRAIRRVGELRENLEAGSISHYILPIIENYAYNTDEKMRNISNEAVTSLGLLIRNVSWNQIKSFFKRYIAKLRVSPPENLRTCVHVVVEVSSSLFVSLPKDESLVDTFILGDIMPILQKILNERNDETIVNRIVLSEALVNLVKCLPETKIDEQLPGLLTSTCQVLRSRSEELRDSSRKSLCKIASSLGAKYFKFLLQELKSALTRGSQIHVLSYTMHSLLVSIMDNLVHGDLDDSVTLIVEIIMEDIFGAAGQEKDAEGYTSKMKEVKYKKSFDSGEMLTANISLTTFNQIIDPAKLILQERISLKMQNKLDELLRRYALGLNHNEESDSRNILILSYQINRQSSGIFEETNGKKNQCIGDKLNFETTGHFMVKLNARPLKIQSDFSQYKFTLQRFSFELLRAAISRHSSLLTVSSMQQFIPLLEEGINSGHEGLISTCLRLLHTFVQLPFPDETNQVFKKCARKALTFIKDSPNTTNEVCQSSLKLLTTLIRHKSDVNLKDSAISYVLERILPDLEEPKTQGLAFNFLKAVVSQHILLPEVYDVMDVVSKIMIVNHNREIREIARSIFFQFLMEYDQGRGKLEKQFKFLVNNLGYATQDGRQSVLELINSIVEKSGEELLNKVSSSFFVALANILVNDDSSRCREMSSMIITKMMQNSSESKLEQIEQYLTAWLKQDQNTILTRCALNVYKVYFNQFGLGKSGDIDDLVFQKLKEVFEKSDSQTSSDVSNAEDVEWQLVYSCLNIFATICNKEKRKVVGEAYKGIWKTIINTLLFPHSWVRLSSSRLIGVLLSNLDKCSFKISDYEVQTIAYRLLHQMSAPGVSDDLGNQIIKNLVLIAMRWMKNNTQFIHNQAHEDNDSVEKNEIRKSKKYELANEFLIHRACSTIRQDSHNSLSSKKSTIKLCAMLIQIFDDEFVVSVSEELVLSLYNYVDTNSNGNVEPDLVEIAGECLQMLENKMGSSTYSQVYADVQRTIYLRRQERRTRRAQLAVTNPDISARRKLKKHEKSREKRKHEKDENGYYHSKRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA00</accession>
    <name>G3BA00_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114829</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA00"/>
    <dbReference type="STRING" id="590646.G3BA00"/>
    <dbReference type="eggNOG" id="KOG2239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057806_2_0_1"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="8">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="179" mass="19828" checksum="CC3171F2B3AFF4F5" modified="2011-11-16" version="1">MSIEEIPQGADIQVISKNEKKARDAIKKFNLKQIKGISRVTFKQRGNLIYAIDTPEVYKSVSGTYIVFGEAKVDDINQRFADQAAAGEDDHEGHDHSHEGHDHSHEDKSPESITADLEKASLGGATVEEEDDDEEVDDTGLDPKDIEIIIEQTKVSRAKAVKALRKHDGDMVNAIMEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA54</accession>
    <name>G3BA54_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_108032</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA54"/>
    <dbReference type="STRING" id="590646.G3BA54"/>
    <dbReference type="GeneID" id="18246000"/>
    <dbReference type="KEGG" id="cten:18246000"/>
    <dbReference type="eggNOG" id="KOG3493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156193_2_0_1"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000052">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="73" mass="8441" checksum="86EBEC6841B9FE03" modified="2011-11-16" version="1">MIEVSVNDRLGKKIKVKCLPSDTIGDFKKILSLQIGTNHEKIVLKKGNQIFKNHITLDDYEVHDGFNFELYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA68</accession>
    <name>G3BA68_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114835</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA68"/>
    <dbReference type="HOGENOM" id="CLU_2460682_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="89" mass="10078" checksum="E0A2980310F33B0F" modified="2011-11-16" version="1" fragment="single">MTIQRLQTDIDVLFRVRAAVEEVVKKKSGGGTTRLWRRKCRYTIELVTGVWSECMGPFKKQTVVPGTRQTQRGFSSIMLSTHFSSKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAH0</accession>
    <name>G3BAH0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_108298</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAH0"/>
    <dbReference type="STRING" id="590646.G3BAH0"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020879_1_0_1"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="353" mass="40866" checksum="29D54388465BBBD7" modified="2011-11-16" version="1">MSRRSTRRNYSERVGSQTEDEVVDGTQLTLLPNGDDDEVDEEDELEVTRCVCGNDDLNSDTINPAMASLLQAEYQIKVDQGLFIQCDKCSVWQHGYCVGLFTNDDVPDKYWCELCKPDLHIFIHESSDSNRTLYRPVNEKRKKLIAENDKFTKRKFTRKDRRSYDYDEQLQKALRESAKESGIPIEEQTRRNERSRESNETNNEIGDEEDEVEGEEEGEEDDENSEIKKEAAKKKSLKRAKRKEGSRAKPKKQKTDSNNSNGSGLSKEELINQSSKPRFVNDKSSIYELRKRISAILEWLSRSQLELGDEKELKSSMTNDVTLIENYEENLGLMQSLTVKILNWEEKYGKYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAY1</accession>
    <name>G3BAY1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_135429</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687650.1">
        <property type="nucleotide sequence ID" value="XM_006687587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAY1"/>
    <dbReference type="STRING" id="590646.G3BAY1"/>
    <dbReference type="GeneID" id="18249877"/>
    <dbReference type="KEGG" id="cten:18249877"/>
    <dbReference type="eggNOG" id="ENOG502SCC0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133356_0_0_1"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV61480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="116" mass="13448" checksum="24B74B0418AA69AD" modified="2011-11-16" version="1">MSKQVALERELAQLTQINSVVGKLVSTIQTANSDIHKVHGSINNTNELLFKWVQILSQTTYTKDIISNSNWNGEDIDLDKKLTEEAELKRQLNELERENEQLADRLEQDDTKRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBZ1</accession>
    <name>G3BBZ1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136617</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBZ1"/>
    <dbReference type="HOGENOM" id="CLU_1089890_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442633" evidence="1">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="255" mass="27890" checksum="495EA2AFBEF21CA6" modified="2011-11-16" version="1">MKFEFAFLILHACAASFPMMVPTGQIVDLTGLWDPSTISRHSTVQVSSVSAWDSFSSTDLSHTVYLVNDLEEIPTVYTDKIDPQNRFVAVANKESCFYDPEQESWVKSQYDLNVKYYPHTIDHGTCLDMSMGQGGSLTSAIGITFSASVDLAASFSLKVAELDLSLLLDFLDSEFIFAPSVSIKTSVSCDTKQGEYGRILTTLYLAEAPANNLTKIKFVEGWGVLETAGSVVTAPIKLVTSRVPSSICHRSEVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC23</accession>
    <name>G3BC23_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116830</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC23"/>
    <dbReference type="STRING" id="590646.G3BC23"/>
    <dbReference type="GeneID" id="18248466"/>
    <dbReference type="KEGG" id="cten:18248466"/>
    <dbReference type="eggNOG" id="KOG0746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033361_2_1_1"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="388" mass="43516" checksum="21E6D2B7A59FB2EB" modified="2011-11-16" version="1">MSHRKFEAPRHGSLGFLPRKRAARHQGKIKSFPKDNKSKPVSLTAFLGYKAGMTTVVRDLDRPGSKMHKREVVEAATVVDTPPLVIVGVVGYVETPRGLRSLTTVWAEHLSEEIRRRFYKNWYKSKKKAFTKYSGKYAKDPASIERELARINKYASVVRVLAHTQIKKTPLSQKKAHLAEIQINGGSVADKVAWAQEHFEKTVSVDSVFEDGEMIDAIAVTKGHGFEGVTHRWGTKKLPRKTHRGLRKVACIGAWHPANVNWTVARAGQNGYHHRTSINHKVYRVGKAGDESSGATSYDRTVKNINPMGGFVRYGLVNNDFIMVKGSIPGTRKRIVTLRKSLYTNTSRKATEPVNLKWIDTASSFGKGRFQTPAEKHAFMGTLKKDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC31</accession>
    <name>G3BC31_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_111192</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC31"/>
    <dbReference type="STRING" id="590646.G3BC31"/>
    <dbReference type="GeneID" id="18246256"/>
    <dbReference type="KEGG" id="cten:18246256"/>
    <dbReference type="eggNOG" id="KOG2035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_5_0_1"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="359" mass="39658" checksum="8141698429DD8F3B" modified="2011-11-16" version="1">MSLWVDKYRPRRLDALSYHAPITASLKALASTGDFPHLLVYGPSGSGKKTRVYATLHELFGPQVEKLKIDVKTFTTSSNRKLEFNVLSSPFHLEITPSDMGNNDRVVIQDLLKDIASTEQVDFSNSKNNGTPKHRFKVVIINEADSLTRDAQAALRRTMEKYSANIRLIMISNTTSNIIPPIKSRTLLVRIPAPSVADITAILADVATKESVHFTADPVQSGFLSQVAANSDQNLRRALLSFETISMSNASVACDGQNAVVTLDWEVIIKNVSSSIYTNRSVSNLAKTRVVFYELLAHCIPARIILKGVLFELLRLCNNHSKAQQLVEIGSMFDERLSLGSKAIFHLEGFVAKAMVALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC65</accession>
    <name>G3BC65_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_99650</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689344.1">
        <property type="nucleotide sequence ID" value="XM_006689281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC65"/>
    <dbReference type="STRING" id="590646.G3BC65"/>
    <dbReference type="GeneID" id="18250871"/>
    <dbReference type="KEGG" id="cten:18250871"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_1_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="114"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="219"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="314" mass="34320" checksum="3B0234137664AFFC" modified="2011-11-16" version="1">MPDPQSQPLAWLKDPSNASLIAGGVAGAVSRTVVSPFERAKILLQLQGPGSNQAYNGMFATIFKMYSDEGWRGLFRGNTLNCIRIFPYSAIQFAVFENCKNTILAKWPRPSHELTSAERVVASSMGGFLSVLATYPLDLIRARISVRTASLAKLDKGKLMKPPGVWATAREVVVNEGGVLALYRGMVPTSLGVVPYVAINFTLYEKLRESMSQSSRDFSNPGWKLAAGAFSSFVGGVLIYPLDVLRKRYQVSSMAGGELGFQYRSVGAALVAMFRDEGFTGAYKGLTANLYKIVPSMAVSWLVYDTLRDSIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC76</accession>
    <name>G3BC76_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_116160</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690238.1">
        <property type="nucleotide sequence ID" value="XM_006690175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC76"/>
    <dbReference type="STRING" id="590646.G3BC76"/>
    <dbReference type="GeneID" id="18248193"/>
    <dbReference type="KEGG" id="cten:18248193"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035525_0_0_1"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF22">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ASH1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="170"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="574" mass="65119" checksum="AE7CD75726B85105" modified="2011-11-16" version="1">MATKRKSTSTTGSARKKAKSLPSVEEFQNFYSSSLKLIYDLRDDANERVLVTPFIKLPPKKLYPDYTDIVSNPITISDIQRKVTKGKYSGTDAQEFLDDFKLLLDNAALYNEPDSWVVADASKVYEFVREQVAQFVDDVVGESSHELTNDDLLQAAEQLLNSVIEHEFPEIGVISGPFMDNINKKEYPDYFKVIKNPTSFNKVLGELDTSIIIPEDPVDENLERLYEETKLIFSNAQSYNDPNSLIHQDSLKLEELFEDKFQELRTSFIPEAKPLKFKIPAVAAIPEKPEPKKRGRKKKVVVESEPEESENDSDEDDIEDEEVLEEGAPAPEVKEEEEAPPIPTLESNVMGRTQTLGSTDEVFIKDAYIASSASTVSQILSQTQEFNNYRASQPVSRYQLIKDTLFSNATDSLSTLIEYKFPSNGYCTQSYTFSLPSDSSSYITMKFNLHDYLFGLKEEDIRNGQSFAGVASDEEFQCKLFVNDNEVENGSDSDDTSDVNRLRLSYDLKLSFGLNIVTFECKVSPSVSKLIKKSSTKPEESEEVAGRHTRHQLQQMKRSWEVEKYTFFIICNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCF1</accession>
    <name>G3BCF1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ras-related protein SEC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_116885</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle</location>
            <location evidence="14">Secretory vesicle membrane</location>
            <topology evidence="14">Lipid-anchor</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCF1"/>
    <dbReference type="STRING" id="590646.G3BCF1"/>
    <dbReference type="GeneID" id="18248489"/>
    <dbReference type="KEGG" id="cten:18248489"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000961">
        <property type="entry name" value="Ras-related protein Rab-8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV60819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="203" mass="22583" checksum="F5642BA763058913" modified="2011-11-16" version="1">MSGRAPSRSYDMIMKLLLVGDSGVGKSCLLLRFVEDKFNPSFITTIGIDFKIRTIESKGKKIKLQVWDTAGQERFRTITTAYYRGAMGIVLIYDVTDARSFENVDNWYQTVTQHANEDAQIFLVGNKCDDSEGRQVSTEQGQELAARLNIPFLEASAKSNINVDSIFYELASIIQDKNVDAEPEKKSTGIDVSKGALSKNSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCF8</accession>
    <name>G3BCF8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_96267</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCF8"/>
    <dbReference type="STRING" id="590646.G3BCF8"/>
    <dbReference type="GeneID" id="18250593"/>
    <dbReference type="KEGG" id="cten:18250593"/>
    <dbReference type="eggNOG" id="KOG0128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333463_0_0_1"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12299">
        <property type="entry name" value="RRM4_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="614"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="709"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="884"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="909" mass="104639" checksum="6B38A59BAAB37AF0" modified="2011-11-16" version="1">MDIEELQQRVQEQPFELSQHDTLISALRLHKTTKVLDLYQARVNKLEYFTLRHDEINEILEDLMAIDDKNTRIELVDGFYNLLIREYPTSSYWLRYLDFASQVKSHSELHEMYTRALNDTVHDFENSHLIWNKVLEFFTEIPEGSTPGSDQIQMWWKLHIKRLSYPHNKLEQSFSDTSEFVSVYFPDKYDEFMTMASEVHGTTQRSQIYYEKHEVHLTSKHKDPDFWARYLADVGKYSTDLRQVSTLFYRSLMSAVSDWVPVWTAYIFLLYSKDDNTKFLMDILPKFVCSFPGAFHPYVEYIRNMELFDEPELYDRIRDRIEYMKLLNPTSQGWQLIATTILSFENRVESPRLLGDVKRFFTGAVADNSVVSAEDNAHSVEKICISIYESRGLLEEAKHLVSKLTLVFGGESAVWIYALRFFERNHFKYEDVSRFLHTAIAAAVEMDSPVQLINEALLYEQVYGTRISLQKAVVRANIVYRTINEKKAESEDEDTQWNQSAVAEFVSTPGVTTRKRPLDTHEPIPKKVKIDKPTRNREELSVKVTGLPANVPECTVEQFFQDCGVVRNVVVFHSGEGCEAVVEFEDNQAIFAALTKSHKKLENQEVLVKRMSHCILWVCNFPPSMDKTKLIKVFEPYGTVIDVRLPFQNSQHRQRRFAYIEYAEGEQARAAVSQLNGKMLHDDLNDSTYKLVAKFSDNSAERGPPVFKRQIYVGNIPYDTTTAQVREFFQVYGRVENVTLPISTQTKERGHMNSGYGFVLFQSETSIAQALTADGSSFRDRIIKVSASKPSQVDIVNELRPFNHQSSLALYQVPKTATREQLSLYFKQTTGVKPTRITIFPDKEAAAVQFASTSESGKAGLAIQSHQFNSTFLKADSLDTLTSSVPREAPVPSPGPKRNYFIPASVQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCP0</accession>
    <name>G3BCP0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116904</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690058.1">
        <property type="nucleotide sequence ID" value="XM_006689995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCP0"/>
    <dbReference type="GeneID" id="18248499"/>
    <dbReference type="KEGG" id="cten:18248499"/>
    <dbReference type="HOGENOM" id="CLU_1189778_0_0_1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="233" mass="26596" checksum="139936FC31043B71" modified="2011-11-16" version="1">MFSRDSKTRRPLSQSLSLTNLHLFTRSREPSLSHTKSSAPLQNITNTAINTSRSRPAKQRYSSLFDKENETRQRLHKRFSVNFKQVEDSDSDDETIKSINTSPFTNNDMMSLNLSSITLEDEEPSKDKPELSKSELPKDDKRMSRMSNLSSILEFVHQINYDVAPPFGDPAKSKVFEEVQIGQFNATSDYHIKLVHNAMLFQYDEADIVDPLGLDDIDYAAVFAAPYHEELSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCW1</accession>
    <name>G3BCW1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_136711</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCW1"/>
    <dbReference type="HOGENOM" id="CLU_034005_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="577" mass="66456" checksum="27D2B0C7E34E7357" modified="2011-11-16" version="1">MMVRLLSFTRFDHDGRGLKREGNVSSILKNRTSTNGLIMVFDFRKEQAAQRTFFSTFKSSVRGCIGVTADFQSYHYYSIFDKTSALAKYDGTLDNEVDYFNYSTIFGKEDRCFGNPQGLVKSGGLTSLTSDLDLYEFFTIFGKCEEQYSTDYNFYDFYSIFENHKTKKHQKTQNSYKNNKLEENYYDFFTISENEKQPYSTDYNFYDFYSIFENQNTKKNQKVQNSYKSYKTENCCYSLTSDFNGFNFYNLFKDCAQSASGFELYDFFKFFEEKVPVSGSKVYEFYTGSQKKSGYSLEKLKSEFVYLPKSNFSSKVFLSIWESSSFPKSVRLANGEIVTETLGKALLPKCQSVSLPTLNSLPSLQKVPKDYGYTYIFKLGAVLANRSLSSLHRLDVHLRNSCSVYLPDNVSTFNFQPKPEMVSMQTYWKSSKRTQYSLELVSTSKEMFLALKESTISEMVWEYFSDDDMSIASLSPSILEASDYGKDVCEKFSSSCSSLMALSPLIPETDLSLVEQREAIRQILDSKPKLMILPAPDGDLEGKAVDKQHLSPFRKVFSKLKPRKLFALFASIRHSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD19</accession>
    <name>G3BD19_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pheromone alpha factor receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_137362</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD19"/>
    <dbReference type="STRING" id="590646.G3BD19"/>
    <dbReference type="GeneID" id="18250059"/>
    <dbReference type="KEGG" id="cten:18250059"/>
    <dbReference type="eggNOG" id="ENOG502QTV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038593_0_0_1"/>
    <dbReference type="OrthoDB" id="5402633at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038038">
        <property type="term" value="C:G protein-coupled receptor homodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14939">
        <property type="entry name" value="7tmD_STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.920">
        <property type="entry name" value="Pheromone alpha factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027458">
        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009:SF1">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46476" checksum="C40F3FA6F3EB35BF" modified="2011-11-16" version="1">MDSYLLNHPGDISLNFALPLSDEVYTITFNDLDSQSSFSIQYLVIHSCAITVCLTLLVLLNLFIRNKKTPVFVLNQVILFFAIVRSSLFIGFMKSPLSTITASFTGIISDDQKHFYKVSVAANAALIILVMLIQVSFTYQIYIIFRSPEVRKFGVFMTSALGVLMAVTFGFYVNSAVASTKQYQHIFYSTDPYIMDSWVTGLPPILYSASVIAMSLVLVLKLVAAVRTRRYLGLKQFSSYHILLIMFTQTLFVPTILTILAYAFYGYNDILIHISTTITVVLLPFTSIWASIANNSRSLMSAASLYFSGSNSSLSELSSPSPSDNDTLNENVFAFFPDKLQKMNSSEAVSAVDKVVVHDHFDTISQKSIPHDILEILQGNEGGQMKEHISVYSDDSFSKTTPPIVGGNLLITNTDIGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD89</accession>
    <name>G3BD89_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_111960</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD89"/>
    <dbReference type="STRING" id="590646.G3BD89"/>
    <dbReference type="GeneID" id="18246331"/>
    <dbReference type="KEGG" id="cten:18246331"/>
    <dbReference type="eggNOG" id="KOG2702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067202_1_1_1"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="223" mass="25107" checksum="99187B16A02CA8D3" modified="2011-11-16" version="1">MTVDKYLASDIDMLAQRVLKLGEAYDGTNRIIITISGIPGSGKSTVAAKLMLQLNKLTSDVVMLSQDGFHYYRAELHSMPNPSEAIARRGAAFTFNVVRFVELVRKIKYDLNSTIYAPDFSHTLKDPEENKIPIHPHHKVVILEGNYVNIAHGDWKFIGEVATERWMVTADPSLVRDRVIARHLKAGISKTYKDACHRVDTNDLVNAYFILQNSPTPDVEIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDD7</accession>
    <name>G3BDD7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_110622</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDD7"/>
    <dbReference type="STRING" id="590646.G3BDD7"/>
    <dbReference type="GeneID" id="18246208"/>
    <dbReference type="KEGG" id="cten:18246208"/>
    <dbReference type="eggNOG" id="KOG2767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_1_0_1"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="6">
        <location>
            <begin position="239"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="401" mass="44641" checksum="8ADA46D5AD183852" modified="2011-11-16" version="1">MSFINICRDNTDPFYRYKMPPIQSKVEGRGNGIRTAIVNLAEVSRALGRPPTYVLKYFGSELGAQTNESQDRYLINGAHDANELQDSLDGFIKKFVLCASCKNPETEIQVKKDILQRDCKACGHLSLIDPRSKLSSYIMKNPPDGGKGKKGKKAATATANVVGGGKTIADLVTDQKNDDESGETSLVVDENDDDDFLTKKINAEAAALADESIEVNDDDWAVDMSKEAIEARAKLDGLTLDSNAEFNQLGEWLLEESKDSKEDLPSDIDIYKKIVELEILDKAETIQVLAQTLFDDNIVEQIEEHLGLLAKLIKQEEENSKAFLGGLERYIGLENTSLIEKVPKILMALYDKDLISEEVIISWGSKVSKKYVPKEVSKKVRKAAKPFVKWLQEADEESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDL5</accession>
    <name>G3BDL5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_116383</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDL5"/>
    <dbReference type="STRING" id="590646.G3BDL5"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="69"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="324"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="381" mass="43572" checksum="3244F87479A925F8" modified="2011-11-16" version="1">MNQEPHIMTASSTGEVNIASTTPIDEVVMTSGSSGSGADDDKPSSSQSKRSKHLDKDTTTKGKYTLNDFQILRTLGTGSFGRVHLARSIHNGRFYAMKTLKKERVVNMKQVEHTNDERRMLKLAQHPFIIRMWGTFQDCHNLFMIMDYIEGGELFSLLRKSQRFPIPVAKFYAAEVFLAIEYLHDLDIIYRDLKPENILLDKNGHIKLTDFGFAKEVIDVTYTLCGTPDYIAPEVVATKPYNKSVDWWSFGILIFEMLTGYTPFYDPTPMKTYENILNGTINYPDYLPPDILDLLQKLIVKDLTLRLGNLQNGSDDVKNHPWFKEVIWERLLSRDIETPYEPPITSGVGDTSQFDRYPEDKDLDYGISGVPDPYGDMFNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDU2</accession>
    <name>G3BDU2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136864</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDU2"/>
    <dbReference type="HOGENOM" id="CLU_093529_0_0_1"/>
    <dbReference type="OrthoDB" id="4088947at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="260" mass="30529" checksum="27051B05AAC792A5" modified="2011-11-16" version="1">MFSRMNMFRTYRPRFLTRWLSSNGPHPLPPNPRINLRPKPLQLPTIFGLIVFSSTFTMGYYSAYQLGDFFLSDETSRSIFLPLWINFNYFFKSSYSESNLKYLDIENFSFDTQSVNKRIKFKILNLLVNNKTIAFRHLLHWANVELVNHNTSYRFQVNCPSISGLKFVATKPIDNCSITELEVTTNWAIKLINLRFFLLNQPTLQFTDISYSFVGEYDVFEDTHVGKVKVDGIVENNDIKFRNVSLVLHKNNQEIEYKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE33</accession>
    <name>G3BE33_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116497</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE33"/>
    <dbReference type="STRING" id="590646.G3BE33"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55851" checksum="E472E085BBB86B53" modified="2011-11-16" version="1">MSLEQEFKEAPLAAEDETKSNNDVNSNSSEQLVQELADEYGINQKKLMWKVDVCVVPGFCLLYFLSFLDRVNISNARLYGLEEDLNMTGDQFNIALALFYVPYVAFELVSNYSLKFIRPHIWLSSCIFLFGCVTIGMGFAKTFGQLVACRVLIGMTEAATFPGLFYILSSFYANFEAQRRFSIFFSCTCLAGGASGAIAYKINDLNGVHGLVSWRWIFIVEGAFTAGLAFVLFLIVADFPEDARFLKANEKTFLKKKLAIYSGAESGYEITNKVSDVVKCFKDYLIWLPALAYFGFIIPSYGYAYFSATIIKEMGYTAVSANQHSVYPWLAAFGFSVIIAFTSDHLRIRLPFVILCLVVAITGLAMVLGATDYPKVRYGGCFLIASGLYSGMPVLVCWNSVNFGGHLRKSVGTAWQIGFGNIGGIIATFIFLTKDAPVYRSGMAVCISSACFAIICSTAYFFAVRRLNSIKQTDTYVEKFNALSERDQILAGDKNPNFRYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE36</accession>
    <name>G3BE36_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_116498</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690361.1">
        <property type="nucleotide sequence ID" value="XM_006690298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE36"/>
    <dbReference type="STRING" id="590646.G3BE36"/>
    <dbReference type="GeneID" id="18248334"/>
    <dbReference type="KEGG" id="cten:18248334"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006421_2_0_1"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="533" mass="60544" checksum="2D514B7C26B66A36" modified="2011-11-16" version="1">MGLLSFKKKKESLFDLSPFPNLPKNYKLLNMIGEGAFSTVYKAKNLTNGNSYAIKIINKSNLNEKQLENVTNEIDIMRNLNHKNLLKLIEFYNYHDFCYLILEYCNGGEIFNKIIEYTYFSEDLSRHVFIQLLKAVNYLHQNNVVHRDIKPENLFFNRIKLFRRSSEEYKATLRSSDDETKLDEGAFMKGLGAGTIGVVKLGDFGLAKKLTPLISQTTPTTNTRYINNLKTPCGTAGYTAPEVITANQDIDKQNYYSKAVDIWSLGCLLYTILCGFPPFYDDDSSKLTLKILNGDYTFLSPWWDEISDEVKDLIAKMLVINPNNRITIDEIFNHPWIKDEIFSQDYFNINSKFENNDLTVSKTPIDRVEHIEHRSGSSNSDTVGTLVLDPDDPLSEQPSPYNLPTSAVDIPKPIPIPAASGHSTNPLLSPRATAIKSVFNNPAMNEFSGLKFNNKAIFNIEEEQKDILTNLHKLIIKSSIPNTISSSNSDSDDEDYQTRQSSIISGDRSNEKFQLNMNDSNLISRRRSTKTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BET1</accession>
    <name>G3BET1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_137066</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689800.1">
        <property type="nucleotide sequence ID" value="XM_006689737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BET1"/>
    <dbReference type="GeneID" id="18250035"/>
    <dbReference type="KEGG" id="cten:18250035"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="182"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="371"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="9">
        <location>
            <begin position="780"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="98290" checksum="3B8FA75D0A27651F" modified="2011-11-16" version="1">MTDSRSTSTSAVVSSLLANLALFGCFLGGFLLLRVKFKRIYSPRSSFKIGPEESQPPELSIDPISWIFKLLFRTQSQVIQYAGLDGYFFLRYIFMMMAIFFGGVFTYVILLPINATNGNGNEGFDQLSISNVKDHNRYYAHVLVGWVFYGAVMAVIFRELFFYNSIRCAALASPKYAKKLSSRTILFQSVPDALLDEKQFFKMFNGVKRVWVVRNLRKLDGKIRRRTNLVHKLEAAENSLLAKAYKRKLKSEKKKVLVEDPGNINSYVPEKKRPRHRANGLFKSKVDTIDYCLEEIPKVDAEVKKLQKAHKTSKPKNSIFVEFENQYTAQLAFQSTIHHNPLRMKACATGMEPGDVIWANLRLFWWEANVRTLIAIAAVTAVIILWAVPVAFVGVISNITYLTNKLPWLRWILKLKKKLLGIITGLLPTILLKVLFAVLPVFIRANGRVAGCATVQQIELFAHDTYFGFLIVNSFIVVTLASSASSVVTQIIDNPTSAMQLLASNLPKASNFFISYIVLQGFTISGTTLFQVVSLFVFYFLTTLLDKTVRKKHTRYTTLDGMTYGTTFPVYINLVCITLAYAIISPMILIFAFLAFLLVFLAYSYNLTYIMLPGPDVRGMHYPKALFQTIIGIYLGQVCLLGIFVVGKGWGPIVLQAIGIGFTAFCHYTLNQSFGHLLSVVPIDVMKPLDGVSETPSYNGQTDYKTKVLDVRRYRHHQSQPDKHLEAAIANENKVNSQVKQDLIKEDAEINQNETVYSVTPVLADRDMKKLESTNWFVRFIRPDVFANYRHARRLLPANYNVEPDEVDDRHAYSSPNVAQTLPTIWIPEDPMGLSKIEIEKAKAKSAISMSDQNAGFDTKGNFVYTGPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEZ8</accession>
    <name>G3BEZ8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Threonine dehydratase</fullName>
            <ecNumber evidence="14">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_111687</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="14"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEZ8"/>
    <dbReference type="STRING" id="590646.G3BEZ8"/>
    <dbReference type="GeneID" id="18246306"/>
    <dbReference type="KEGG" id="cten:18246306"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_6_0_1"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="15">
        <location>
            <begin position="389"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="15">
        <location>
            <begin position="491"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV59975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="572" mass="63299" checksum="B956EB63B129452E" modified="2011-11-16" version="1">MWKNTVSKLLRVGRAVHTTKPALNGASVRKLATNASAREKFPELHDSDFGPDGNPDYVKLILTSRVYDVVDKGGSPLNFAVNLSQKLGTNVHLKREDLLPVFSFKLRGAYNMIANLHAQKNSHLDGVIACSAGNHAQGVAFSANKLGIPATIVMPTATPSIKFKNVSRLGSQVVLYGDDFDSAKEECDRLSVLNNLTNIPPFNHPYVIAGQGTIALELTTQLRLDKLDAVFVPVGGGGLIAGIAAYLKKIAPHVKVIGVETYDANALYESQKSNELESLNSVGVFADGTAVKILGEETWRVCKDIVDEVVLVSTDELCAAIKDIFEDTRSIVEPSGALSVAGLTKYIRKNKDVDHHDKTYVPILSGANMNFDRLRFVSERAVLGEGKEASLVVSIPDRPGEFAKLQSVINPRAVTEFSYRYNNTDSANIFVSFNLASRENDLEKIIETMKSEKYGFEVEDISKNEFAKSHGRYLIGGSFSHSKPEKVARERVYSFEFPERPGALFRFLRSLKPDWDITLFNYRNHGNDVGKVLCGIATPEETTEEDFQEFLKTLGYRFIDETENVVYRKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF23</accession>
    <name>G3BF23_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_116017</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF23"/>
    <dbReference type="STRING" id="590646.G3BF23"/>
    <dbReference type="GeneID" id="18248127"/>
    <dbReference type="KEGG" id="cten:18248127"/>
    <dbReference type="eggNOG" id="KOG1599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048151_0_0_1"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV59992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="304" mass="34424" checksum="5D764278D3EC0E36" modified="2011-11-16" version="1">MQSQLVSSSYGKGNVKFLKVKKDPSNPQIQDVLEANVKVLLRGNFDVSYTDADNSPIVPTDTVKNTILVEAKNTDVWPIERFAAHLAKHFISKYDHISGIEITIVQAKWSKYEVNGKLHAHSFKHEGPETRITVLDYTRASKQLKITSSIKDLTVLKSTGSMFYGYNVCDYTTLQPTKDRVLSTDVDASWVYDSKYLRTLDDVFSYADKGLFDDAYNGARKITLDKFALENSASVQATMYNMSHEILLQVKEIETVTYQLPNKHYILFNLEWKGIKNNTDLFYPSPDPNGLIKCTVGRKVSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF33</accession>
    <name>G3BF33_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pro-apoptotic serine protease NMA111</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pro-apoptotic serine protease nma111</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_132335</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF33"/>
    <dbReference type="STRING" id="590646.G3BF33"/>
    <dbReference type="eggNOG" id="KOG1421">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003212_0_0_1"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06786">
        <property type="entry name" value="cpPDZ1_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10827">
        <property type="entry name" value="cpPDZ3_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF8">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="265"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="752"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="959" mass="107705" checksum="4BDB6F0428C9EE95" modified="2011-11-16" version="1">MTNPSLSTKRRRSEISTGIPSETDPKRFNGQIKSDMEEDTQSYYSDTDSQIPSTITKVVKSVVSIQFSHVANFDTETAIVSEATGFVVDNQRGLILTNRHVVGPGPFWGYAVFDNHEEAVVKPIYRDPIHDFGFLQFDPSDIKHMELSQLELRPDLGTVGTEIRVVGNDAGEKLSILSGFISRSDRNAPDYGSLTYNDFNTEYIQAAASATGGSSGSPVINEDGYSIALQAGGPLRALKCIQQQLPITRGDIQVEWQLKPYDECRRLGLTPEVEAKQRELFPEKIGMLVAELILPEGPADGLIKEGDTLISINDEPICTFIKVDEILDESVGKDLTFVIQRGGTELTQTIKIGDLHAITPDRYVEVAGASFNTLSYQIARCYCMPVRGVYINNASGSFELSPFEKNGWLLESVDDKPTPDLDTFVEVMKSIPDLDKVVITYRHVSDMHSELFRVVYIDRHWCSTFRLAQRNDETGLWDYKTIQENPIPPTQPTPKYAKFIDIPFIDESRSECSKMVRSFVQISAYCPISLDSHPYKKLIGHGVIVDAANGYVLVSRRNIPHDLCDVLIIFAESIDVPGKVVFLHPHQNYAIVKYDPSLITADVRTPKFGSKPLKRGETSLFVGYNYNMRLVTEDVKVSGVSSLNIPAAVYSPRYRGTNLQCILLDSKLSQECYTGILCDDDGTVRAFWLTYLGETNREVDADKTYRMGLDVTDVLEVIELLQKNEIPKHLNIIDAEFTSATVFQGRTRGISQEWITKFEEACEDEISFLVVDRIVASPLDQAPIPLKTGDVLLSINDKLVKEMRDLNIMYESDNIKFKVVRQKKEIELVVPTVDTDALNTTHVLFWCGASIQAPHHGVRQQMERIPSEVYITSRGSGAPAQQYDLAPISFITHVNDKETKDMVSFINVIKGIPDQTYVKIRLVSFDNIPIAISMKTNYHYFPTSEFKKLDSKWESIEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF41</accession>
    <name>G3BF41_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arginine, lysine, histidine permease Can1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_99998</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF41"/>
    <dbReference type="STRING" id="590646.G3BF41"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="40"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="543" mass="59789" checksum="6316397E46BF2831" modified="2011-11-16" version="1">MSDYEKGPDLITSTGSPSGKFHQGEKDLNVQVQRQLKPRHISMIAIGGTIGTGLFVSTGGVLAEAGPVSSLISFIFIGTLVFAVIQGLGEMATYIPISGSFTQFTTRWCSPALGAANGYCYWFSWAITYALELSVVGQIIFYWTDAVPLGAWIGIFFVILTSANMFPVKFYGEIEFWISFLKVIAVFGWLIYALCIVCGAGKTGPIGFRYWRNPGPWGPGILEENINTARFLGWLSSLISAAFTFQGCELIGIASGEMKSPKSLPKAIRSIYIRIIVFYLLSMFFMGLLIPYTNPRLGGDGYAVSSPFVIAMDLAGTKVLPDIFNGVLLITIISAGNSNIYCGSRILYGLGQAGVGPKFFTLTTKHGVPYVAVIITSLFGLLAFLVLSENGSTVFDWLLNITAVAGLISWGWISVTHLKFMAILKQRGISRNSLPFKAVLMPYLSQYATITIFVLVFLQGFSCFWNITASGFFTSYISVILFVVAYIAFHFYFNGFGKRTFSKEAFWIPVEECDIDSGVREIDEYFVEPEPTNLWEKIWAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AVZ2</accession>
    <name>G3AVZ2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_101113</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AVZ2"/>
    <dbReference type="STRING" id="590646.G3AVZ2"/>
    <dbReference type="eggNOG" id="ENOG502SF7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074843_0_0_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="322" mass="37011" checksum="903E1CA61F36C77F" modified="2011-11-16" version="1">MSEPGASTSPNAHVDIPRGSSDLQDQVLPSTVSGYVGDQVSDPSAEIDKHQQSHIPNEDQSSEEPTALSSSSISSFYGSNKRRIEYTPFDPESLRSETHKKRVPGKFIDRFWEPLDETTAEEFDKILDICLNKAIERYKVVGDLLAHTWTSDHETSFKRRLQTTKLPRRVSIHSTNPQNDENKYVLNHDILNRRKTFLETYLSAELKQLKDLTKTYNKIELNYKSDLEYLKEFNKTVEANESKMSQEVYTKKTTMNLKYSDTSNLDSDVTSSNVRFTPREDDEVNELLEKLDSGLKRVSGNSKDLIDFHERLQNFQDSLDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWD9</accession>
    <name>G3AWD9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112240</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWD9"/>
    <dbReference type="HOGENOM" id="CLU_2757546_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="70" mass="7771" checksum="FF7906A1519E9697" modified="2011-11-16" version="1">MAVQTGIKFDLSTLQGSLLIAVGILFRVKSVQNIVTRRRLNPWQAIPLVVGELLKWAAGVLIFVAFSGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX08</accession>
    <name>G3AX08_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112378</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX08"/>
    <dbReference type="STRING" id="590646.G3AX08"/>
    <dbReference type="GeneID" id="18246501"/>
    <dbReference type="KEGG" id="cten:18246501"/>
    <dbReference type="eggNOG" id="ENOG502S6Q4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2378341_0_0_1"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="95" mass="10554" checksum="3310612C39E65DEC" modified="2011-11-16" version="1" fragment="single">MSQSEDQVPRSPPEASPAPDNDNVVEKNHPNPPSDAFSPTSIVLAKVKGYPPWPAMVLDEMILPDHILARRPKTVKLPPKRKNQGPVLILPVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX71</accession>
    <name>G3AX71_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_96694</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683962.1">
        <property type="nucleotide sequence ID" value="XM_006683899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX71"/>
    <dbReference type="GeneID" id="18250623"/>
    <dbReference type="KEGG" id="cten:18250623"/>
    <dbReference type="eggNOG" id="ENOG502SCYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040309_0_0_1"/>
    <dbReference type="OrthoDB" id="4010961at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="432" mass="49563" checksum="CC68BC1672C4F4C3" modified="2011-11-16" version="1">MRSLSLPTGSALRGWGTVINIIGGAYIGGLIVCFGSLYFLYHDANERQPIPFELSFADQKTAVMAINKDDALKSPRYAVKHYRRLLIELAKKENPKLEFDESDPKNQYRAPFLDSHTLVHKKSNTFANFYIDIVSRYAKALLAKGQLEISVETLQKLVNDDEIFFRLGDAERLSQCGRLLARISPTVDEKESLLKRCITMIGSTFSSIHVDENYLLQNSSRITDELISCLNDMAFAYAKESTHSSLSRHQKQDYLSKALNIYLSNLKTVQQVQHSVVSGQKNQTNYPLFNCNEENLQMLVNEIRSHVSEIMWSKGYKQNAISWSEEVVDDIYYINSSSKRANHILIDVLANLTTMYHQIRNRTSEERCIQLQKGLSHYDSNESSWYDNLVGRFCRIIYNKGPLGVIEKALVERFGPPRRLLEIEEFEDEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX73</accession>
    <name>G3AX73_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_117905</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX73"/>
    <dbReference type="STRING" id="590646.G3AX73"/>
    <dbReference type="eggNOG" id="KOG1020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756490_0_0_1"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="2">
        <location>
            <begin position="76"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="366" mass="41679" checksum="E5CF27788AABA07C" modified="2011-11-16" version="1">MNDKVLNIIATELQNDEDGATKIKQIIVQNLFDFVRHEDKESRRRIGVETKSSSNENLDVVAFNGGGKAYVNDGICSSLIQRFISKILGLCFDPNHTFALISVQFCKLVFTLGYENPKLCISTFIGLEASESSIIRNKAHGVLRDLFNKHESLFDSSYSEGFKYAVEYRSSIADGLSTSRYYISILYSVVSKTVSARRKFITAINKSLQNYSSLDKQDHSQEFGRNFIYFMLQNLASVSFLTLEETYMIAETINNILSHQGLDLYDKVKALEENKSKKVVCIQSQAMICFLEFNSFLISKYGLNVERIANFKLERIDTELRSHPKVQRELVFDLDASDMKADLEEMSTVEAILGKFVSSMHFYNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXN0</accession>
    <name>G3AXN0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_91972</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXN0"/>
    <dbReference type="STRING" id="590646.G3AXN0"/>
    <dbReference type="eggNOG" id="ENOG502QRVJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016176_0_0_1"/>
    <dbReference type="OrthoDB" id="5426978at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="794" mass="87737" checksum="AD3CA87F2CAFEE58" modified="2011-11-16" version="1">MTSQVALKSERISEPQADSKIKLSPSSSEHLPPRTTDDSPYPAPSSNTHGADATADATADANGSPDFPPGSPKPFVHVTGNQSRKRSKVSRACDACRRKKIKCNAQYSTSLQKVTQICTNCSKNQDECTFSRVPLKRGPSKGYIRDLEERAETKLTRNRIVLPPLGSANSGAALPTVNTPLSHSPLSSTPPQGLASGPFWKVPYEMPQGTGHHQNLSSSSSRRGSVDSAASSLSSVSGSGQRSRLPSINATDASMVSDSDDDFYSASSYRHSRRSSASLSPRNSVSSLSSLNGRILKVNLANGTNSPTASLPPVQQFHARSNSHPIMPPLNSPYTPPSPARTVPAGLDQDIKTYYAKFHPPFPILPFNETYILQVVESYAVNVKQDDPVISLFAQAIHQLINYQFVSINDTINLVYKISSIYPFSNFGIQLHDNVLVLFFSSLILVNYSVLLSGNIYSLSLSMTLSVFNDFKILENFNDLVATTSINSFDPGAVDNIKLYLPKLYLCLVVMDQFYALSFGIKTLVPPQNYGPLVSNLSLLIPADVSNRPLFQSVDLMADLLENRDKIIFKTGKDFKLSSDIWGRFNEAFNFNYHSNYHTLFLKLVKSKYESINFLIEIATLFRSDSFVSSSSSNEECQEVLNDHILKLVRLIKTLTTNLTSITDFINKSINKFELVQPVLNISINQIFKLIKLCKLVIDSLVQSVSGDLYHRIYKINSDLLSCFNNLNVILSLNMNVLSTSSLNLIKNKVSGFAMNFNFPTLAPNSSNNLMGWKYDLFSSILPFVEREDVDGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXZ9</accession>
    <name>G3AXZ9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_118328</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXZ9"/>
    <dbReference type="STRING" id="590646.G3AXZ9"/>
    <dbReference type="GeneID" id="18248632"/>
    <dbReference type="KEGG" id="cten:18248632"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_2_0_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000257">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="149" mass="16606" checksum="169DAA494B7CD86F" modified="2011-11-16" version="1">MAEKLSEQQIAEFKEAFSLFDKDSDGKITTKELGTVMRSLGQNPSESELTDMINEVDINNDGSIDFPEFLTMMARKMKDTDSEAEIAEAFKVFDRNGDGKISSAELRHVLTSIGEKLSDADVDQMIREADTNNDGEIDIQEFTKLLSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY17</accession>
    <name>G3AY17_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_129211</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY17"/>
    <dbReference type="STRING" id="590646.G3AY17"/>
    <dbReference type="eggNOG" id="KOG2440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011053_0_0_1"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005741">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:monosaccharide binding"/>
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        <property type="term" value="P:canonical glycolysis"/>
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    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
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    <dbReference type="GO" id="GO:0006002">
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Phosphofructokinase_I_E"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 16 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="167"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="557"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="16">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="16">
        <location>
            <begin position="557"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="315"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <position position="352"/>
        </location>
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            <name>substrate</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="359"/>
            <end position="361"/>
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            <name>substrate</name>
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    </feature>
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        <location>
            <position position="416"/>
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            <name>substrate</name>
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        <location>
            <position position="444"/>
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            <name>substrate</name>
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    </feature>
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        <location>
            <begin position="450"/>
            <end position="453"/>
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            <name>substrate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <begin position="685"/>
            <end position="689"/>
        </location>
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            <name>beta-D-fructose 2,6-bisphosphate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="723"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="730"/>
            <end position="732"/>
        </location>
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            <name>beta-D-fructose 2,6-bisphosphate</name>
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            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="816"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="822"/>
            <end position="825"/>
        </location>
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            <name>beta-D-fructose 2,6-bisphosphate</name>
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        </ligand>
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        <location>
            <position position="903"/>
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            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV65749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="930" mass="101176" checksum="FED5D361E0133419" modified="2011-11-16" version="1">MTAPSIIGSSSFSFYVPNQDYLKQCVDFYTACVGFGVHSRKESCVYLVSENGKLSIEVVAKSVDLRAVESLFILQCINLNDLIKNLQLWKKPVQISPNELFPNECFTVDPLGKVIGFTLTGNPLSTVPKVAKLTPLDHLSTSSTMSHSISNTNLAGTAGLTAGKRRNVAVMTSGGDAPGMNANVRAIIRAAIYRGCKAFAIMEGYEGLVKGGPEYIRELNWEDVRGYLSDGGTNIGTARCMEFRERPGRLQACKNLIEAGIDALIVCGGDGSLTGADVFRAEWPSLIQELRDTNRIDEEQYNSYKHLNICGTVGSIDNDMATTDATIGAYSSLARICQAIDYIDATANSHSRAFVIEVMGRHCGWLALMAGIATAADYILIPEKPASSKDWKEQMCKIVSDHRGRGKRKSIVIVAEGAITNDLEPISCEAVKDVLVSELGLDTRVTTLGHVQRGGTAVAFDRILATLQGVEAVEAVLECTPDTPSPLIAIDENKIVRKSLVDAVRITKSVATAIEAKEFDKAMSLRDSEFIEHLSNFMAMNSADHNEPVLPVEKRKKIAIINVGAPAGGMNSAVYAMATYCMSQGHTPYAIHNGFSGLARHESVRSIDWLEIEGWNSIGGSEIGTNRNTPEETDIGMIAYYFEKYKFDGLILVGGFEAFASLNELEKARMSYPAFRIPMVLVPATISNNVPGTEYSLGADTCLNALTEYCDVIKQSASATRERAFVIEVQGGNSGYIATFASLTTGAQASYVPEEGIELSQLELDIRALKESFASEKGLAKAGKLILKSSNASKTLTSQVLADIINEEADGKFDTKTAIPGHVQQGGLPSPIDRTRAARLAIRAVQFIEEHTDTIAPYKYSSDFPFDDKTISATAAVLGIKSSHIKFSSIRYLYDFETELGRRMPKKIHWARVRDIADNLVGRTRLTRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY44</accession>
    <name>G3AY44_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_92094</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endosome membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY44"/>
    <dbReference type="STRING" id="590646.G3AY44"/>
    <dbReference type="GeneID" id="18250157"/>
    <dbReference type="KEGG" id="cten:18250157"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011862_2_0_1"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
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    </dbReference>
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        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="13">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="505"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="505"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV65766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="781" mass="88671" checksum="7704DFAD3A8FB185" modified="2011-11-16" version="1">MSWFGNGTPSTQELDSKIEEATSESIPNGEFDVAVAFEITDIIRSKKISPKQCMRCLKKRLTNTYQNPNLLTSSLKLVDVCVKNGGYHFLVELSSKEFMDYLVDFIFKVNYNIHDGKVIGNQAKLDVGNLILGLIKNWKLFFKNQLQLNYVETCYNDLVRRGYEFPETDTSEYLNGVFIDSETPADWVDNDECMICYKPFSMMNRKHHCRSCGGVFCQEHSSHSIPLPSLGITEPVRVCDNCHFKLKYKLKENNNLSLSNNKHSRSASQNNVNHEGEDEDLKRAIEMSLKESGGIEVAQPSSHPPSNPPPKGDDEEDEEMKAAIAASLKEFQAQEQSYKQQSNTRAPQPILEEPKSEFYNNIFPFDKYSTPQSDPYQATSPSQYQYSSPPQQSSGPLTPAQHMEKHNQLHSEGLTQNEEDSISLYVTLINQIKTDKSRQSNVLHDKDLNDLHSKVIQIKPKLNRTLRSSIERYETFVALNNKISTITKLYDQFLENKLSQAYGNQTLYNPYPNQQYDENYKDQNGTSYQTQSQHGYSNGYGEQQRYTGYPGQDSNNQYSQPQSTGQYNQPQATGQYSQPQTTGQYNQPQTTGQYNQPQTTGQYSQPQAKGQYIQQQATDPLGQNTGQYSTSFSPQTPTAQPYPSQHEQFEESEPNYDEPESTTQSYNAPIETPSYSQEFTNISAYPPIENTGKLRSEPDYPPTSTYPEQNQYDTGSSIESTRSRFPPIEDVKAEYPQHPSASNISKLPQLPDSFSSPPPTSFTYPSSEETSKRVEEPLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY49</accession>
    <name>G3AY49_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein LOT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112635</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LOT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY49"/>
    <dbReference type="STRING" id="590646.G3AY49"/>
    <dbReference type="GeneID" id="18246613"/>
    <dbReference type="KEGG" id="cten:18246613"/>
    <dbReference type="eggNOG" id="ENOG502RY1I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087379_0_0_1"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="277" mass="31305" checksum="6959CCBDCDE9B4C5" modified="2011-11-16" version="1">MGSDPRLIYEYPNYENTIAFTEYQASSPEKFSLPDDDKFVLYAAGSNYSFLILDKDPNIQLFVHPEISSIQELPVDLFVLNTSFLVWCDSLNKGIEFPYQGILLHALQEPDKLYLQVSTSDLFQVQTQKESELVPTIELVLSPNSKMSRQQDSKLLSKVPDSVESVYHAMSKCSAMHFDSENEDQTDMANTGFDFAHSSLNPEFMEVSVPNSWVNEEPPTIHNTGDADDLECLEESHEEPEEAGMHVDIGFASIAGAIRRREHDEEDSGRAQRSRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY81</accession>
    <name>G3AY81_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_129246</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AY81"/>
    <dbReference type="GeneID" id="18249370"/>
    <dbReference type="KEGG" id="cten:18249370"/>
    <dbReference type="eggNOG" id="KOG1879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002668_1_0_1"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442700" evidence="7">
        <location>
            <begin position="17"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="8">
        <location>
            <begin position="38"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="9">
        <location>
            <begin position="253"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="10">
        <location>
            <begin position="406"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="11">
        <location>
            <begin position="1107"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1392"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1398"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1414" mass="161717" checksum="3F1E336BD658CE4B" modified="2011-11-16" version="1">MQRIILLLVWVHIALCVSNHGDNSLKVMLQTPEWSPMPFHLHLLESIAAIDESLYGSAAYSLVNDDYDEEFLLSAANDELVYQLVHDSAGLDPINKSLADLKTASKYYAPRIQTHFSSYLNDIQPKYRGKCDYDMFGTKLERKPTKQYSWLLSGDRIYCTPDDLFALEFSKRSDMSSQLLPFDRVIGQNSKAPLLILYGDLNHEGFNSMFNNLYQSAEAGKLRFVWRYVPSMGAPDLLPNYASTLDLKNSSTPSSIGDFGLKLASKVLSNNVSPREKYRMLNSILEDFPSHLVDIDSEVVDSDVADSAAANEKMGTSKESVGIYLNGAPVNGLELDAFKLFNRIEEEVNIIQEIIALGFNLDQARTLLVKFALHAAVKLSEFNSGSDENRYKVHENSFVAGAQTKRGGVVFINDIETDENYQEYTTVREKAYIDMIPQLAPGQFPPLKENIHDLIFVINLSNQEQLKVFFTFSKLILDRGIPQQIGVLPFGDSELDIKIAKYFYFLYDTTTSKEALAFLYKIFMRETDNEITELLEHISIQGYEFSPSVYLSTLEKFSITEPSIVFNGIITDLKSDWRRQMGSQIRKDVSALHNGLRANKIGFSMKKFLHQSAKSERNLNIIPKDSSGFKYKKVSVSLIEKSSRFRLRPSLVVKDDIEVWLVGDLSQSAAFNQLIQLFKLMSISSFDIQLRVIDLSKSQLLSKIKQGDLNEKDLDNLLVTLEKESTTLKRADPDSDMKQFVSEQGLPPHHSYILVNSRYFRIDNTFSLKQVESIISFEKSFRLSIFDSFLGKYPEIFESSKVDDFYDEKLGIMFHDWKDLLVTRIMKSFFVDDDKYVDDVARYDFSSMNMYNSFVIDNELEPLVDVLVVVDPLVPYSQQIVGIVKGCINLPFIRTRILLQPQSQYLHLPIKRYFKGVYPSYPIKFDSSGFVDENLSAQFSGLSDDVFSVDLLSPKRWVAMSKFAPKNLDLDYFKFSSLSSKDQEVVFELSKLLIEGFATDVTNASPPGGLTLKVSQGDKEADTIIMSNLGYFQLPIGEGTWNLTTGASPYFNYGLLSASSDPFDSSTVIHKQVPLNVFNLDGLVLRPRLVKQASSLSKAKPIQQDGINIFTVSSGHLYERLSSIMMASVRSNTQHPVTFWLLENYLSPNFKALLPKLAEEYKFEYHLITYKWPMWLRSQFSRQRTIWGYKILFLDVLFPIELDHVIFVDADQINRSDMIDLVKLDMGDAPYGFVPMCESKEEMDGFRFWKTGYWKDVLKDDLKYHISALYKVNLKRFREIGAGDRLRSHYQKLSSDPNSLSNLDQDLPNNMQRTIPIYSLPQEYLWCETWCSDSTLQEAKNIDLCNNPLTKENKLDVAKRLIPEWSAYDKDISALIDTIEVQESRKEYEINTPVFIEDKDEDGEEDDEYEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYA6</accession>
    <name>G3AYA6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_118523</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYA6"/>
    <dbReference type="STRING" id="590646.G3AYA6"/>
    <dbReference type="eggNOG" id="KOG1155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018320_2_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="8">
        <location>
            <begin position="9"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="378"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="546" mass="63854" checksum="2AED0F34CA1F7E79" modified="2011-11-16" version="1">METDESIDQLRTDLLKAQITLSNINLLQASKWCAEAINGLSNASNITQIPTLEFDPYDLQDYSRFILAKSYFDVKEFDRCAHSLVGCKSGNAVFLKLYSKILSLDKKMAEENDGSDLNSKLSKIIQEIESFNSSSNPNHFLYYLLGIIYNKKRNYKLAQRNLLAALKLFPYNWSCWQELINSIIDFDEAMELLNKVKSSKSSLNPSIMFNFFEVVLLQEFYQQSVDVNQTLEKLLSIFPNFNFLKIQKFLICYHSLDYYQAESIFDQILEDDPLRIDDLDTYSNMLYVMEKKSKLSFLAQYSSNIDKFKPETCCIIANYHSMKGEHEKAIMYYKRALILNKNSLSAWTLMGHEFVELKNSHAAIESYRRAVDINPKDFRAWYGLGQAYEVLDMHLYSLYYYQRATNLQPTDKRMWQAIGNCYEKIGKFDESLKSFKKALSIDNTNKPQESHGSYDPYICYKLASIYEKIASVKECYKYMKLCFDQELDWGITDETSKARLWLARYALELKKYEEAYELTKDLNHNNAHDIEEARAIAREARNRMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYE6</accession>
    <name>G3AYE6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Erg28-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_112697</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYE6"/>
    <dbReference type="STRING" id="590646.G3AYE6"/>
    <dbReference type="eggNOG" id="KOG3455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114589_0_0_1"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="147" mass="16822" checksum="2E53820711AD4C78" modified="2011-11-16" version="1">MFIGLQSILPVSTPNGGYLPHWLFFISVVSIFNSVQAYFSTDLSKKVYSNASPSEISPLGVRTFGTWTFITSIVRLYGSWYLVGNKQIFELCFWSFFVAFTHFNLEWLVYKNCKFDKGLAGPFLVSTISMIWMLSQKDFYLSADISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYI3</accession>
    <name>G3AYI3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_92197</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYI3"/>
    <dbReference type="HOGENOM" id="CLU_1309957_0_0_1"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="210" mass="23543" checksum="E7ED9DA19C28B098" modified="2011-11-16" version="1">MPMNQVYWKPPTPKSSRHKSFTPSPKESVTSRFERAIKADGKHYIIRPLTASRSLSASANLGDLGIDEGIDKSASSKPERQPQINQEDVSDMVIDIGLQVRDLVAETALQFVSVKDKLDHLSENINLLRQLHHEQTESESYHLRDSDKKMSMRHQNTRHLGRDGSKYHVSIDGESSGPSGTYIPMITSFIASTCFITPLVVFLIDISSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ04</accession>
    <name>G3AZ04_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_92321</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684547.1">
        <property type="nucleotide sequence ID" value="XM_006684484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ04"/>
    <dbReference type="STRING" id="590646.G3AZ04"/>
    <dbReference type="GeneID" id="18250186"/>
    <dbReference type="KEGG" id="cten:18250186"/>
    <dbReference type="eggNOG" id="ENOG502T5UX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1160996_0_0_1"/>
    <dbReference type="OrthoDB" id="4019261at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="239" mass="26799" checksum="70F82189478D97A9" modified="2011-11-16" version="1">MDTIDKLETISGLRKRKFRSKIPKFKFLSKLFNKKKAIIKELESILKSIKKIKKLKAETPEISTRGLSEKKDEIIESLLVKVFVALKDSELITPMLEFSLTDEQVRGGLVKTTVDLLKANVIPWEEIFTALKESGLAVEVVRFLLTDPETIEGEIDLILELIPRLIEEKVINLEDLLKILPHTYTTTTKTGTTTTETISFPSGGDSVLVELPITTLLTFFATNQTLVVPTPTPTVNGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ77</accession>
    <name>G3AZ77_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_112890</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ77"/>
    <dbReference type="STRING" id="590646.G3AZ77"/>
    <dbReference type="GeneID" id="18246723"/>
    <dbReference type="KEGG" id="cten:18246723"/>
    <dbReference type="eggNOG" id="KOG2456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_1"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="52"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="553" mass="60980" checksum="C9AF61034317CC0E" modified="2011-11-16" version="1">MSPSAEKTELHSTGSTRSTRSGKSSAPSTTTSNSPLKYTPVEEIPVKVKQLVNNFHEHHKLHPLQSRVNQLRNVYFAIKDNEDLICEALAKDFHRSPFETQSLEMCVLLNEILHTISSLHKWSRPEKVHDLTINVATQPVYIERIPFGVVLVMSPFNYPLLLTVSSLVGAIAGGNSVVLKLPESTPHFSSLLTSLLKDALDEDIFYVVNGAIAETTAVLDQKFDKIMYTGSTVVGKIVAKKAAETLTPVLLELGGKSPGFVLNDVKDSQLATVAKRILWGKFSNGGQTCVAIDYLLVDDAIKDKLIKALLEQAELMFPGIDSESDWTHLIHDRAFGTLIDTIKKTDGTIIYGGQSDEKTRFIAPTIIDNVKFNDSTMRQENFGPVLPIISYSDLTSVLKSVIQSHDCPLAQYIFTGGKTSRANPQIDQILTYLRSGGTLINDTLVHVALPNAPFGGIGNSGTGSYHGYFSFRAFTHERTTIEQALWNDFLLKSRYPPFSDKKAAFIKNSMAPQREWFDRTGNVKSTGPSIFYKVYDAIATATSIGYTAIANRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZC9</accession>
    <name>G3AZC9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative peroxisomal hydratase-dehydrogenase-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_102039</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZC9"/>
    <dbReference type="STRING" id="590646.G3AZC9"/>
    <dbReference type="GeneID" id="18245524"/>
    <dbReference type="KEGG" id="cten:18245524"/>
    <dbReference type="eggNOG" id="KOG1206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_18_0_1"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="12">
        <location>
            <begin position="319"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="577"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV66064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="893" mass="97646" checksum="F81C339F990A7865" modified="2011-11-16" version="1">MSEISFKDKVVVVTGAGGALGKHYCLEYAKRGAKVVVNDLGFKNGVSEAANKVVDEIKALGGIAVADYHNVLEGEKIIETAVKNFGTIHILINNAGILRDAQFKKMTPEQYQLIIDVHLNGAYKCTQAAWPYFRKQEYGRIVNTASPAGLYGNFGQANYSAAKSGLIGFAETLAKEGAKYNITANVIAPLARSPMTEGILPESILVQLGPEKIAPLVLYLTHEGVEANGQIFELAAGFYSQIRWQRSGGALFKPDSTFGAELVAKKFEEIVDFDDSSRPELLKNQNPHMVNDYLSLNEAARALKENDLSGAPKISLKDKVVLITGAGAGLGRDYALFFAKYGAKVVVNDFADPSKVVEEIKAAGGEAHGDQHDVGTQYTEIIDNVISKYGTIDVLVNNAGILRDKSFAKMTDKEWYQVQQVHLNGTFHLTRLAWPHFLEKKFGRVINISSTSGIYGNFGQTNYATAKAAIIGFSKTIAIEGAKSNIKVNTVAPHAETAMTLTIFSESDKNLYPPELVAPLLVFLASDDVPCTGELFEGGGGWIGNTRWQRSKGVVCKDKVVTPEFIRDNYSKIIDFTESSNPKSTGESSMEILSAVDPDEDDEDEEEEEDDDEEEIEAEPEFSYTDREVILYNIAVGAKAKELKYVYENDSDFQVVPTFGHLVIFNSPASMAFSKLLKNFNAMFLLHGEHYIKLEQYPIPTEAKVKTTFSPLAVTQKGTNTVVVQGSKSVDTETGELVFSNEATFFIRNCEGETKTYGERKTFATSLFTAPKSAPDFEATIPVSEDLAALYRLTGDRNPLHIDPAFAAGAKFDKPILHGMGTYGLSAKVLLDRFGAFDEIKARFTGIVFPGETLKVVAWKQGDVVIFQTHVVERGTIAINNAAIKLLGNKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZN7</accession>
    <name>G3AZN7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_112504</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZN7"/>
    <dbReference type="STRING" id="590646.G3AZN7"/>
    <dbReference type="GeneID" id="18246549"/>
    <dbReference type="KEGG" id="cten:18246549"/>
    <dbReference type="eggNOG" id="KOG2635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019988_3_0_1"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="14">
        <location>
            <begin position="280"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="194"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="137"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV65631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="539" mass="60636" checksum="03DBC097B436439C" modified="2011-11-16" version="1">MVVLAASICTRGGKALLSRQFRDINKDKITSLLSSFPSLISNSSSQHTAVEDDNIRYVYQPLEELYVVLLTNKHSNILQDIDTLHLFVSTISNLLRTIDEREIFDNAFEILSSFDEIINNGYKENLTLSQVQSFLEMDSHEEKIQEIIERNKEMEANEERKRRAKEIQRKELAKKNLENQFNRPYGFDEAAALNNHNQPSYQPPAIVDNSIESPSSGGYLNKPLTSRSGGLQLGKKPAGRSEASQPLLFNPATNTAVLPNSRSVSMTPTPVVNSAPKVPNNGILVTINEKFNAQLQRDGSILSTEVKGDLQLRINNEDLSYCKILLKTTEKSSEIQYKTHPNVDRNLFQQQHVIGLKDKTKPFPSNDQSLGVLRWRCAGKSDESKFLPILITIWCNPNGDSTDVTIEYELTSEFLENNTTNSSIDDIKIILPVQGDIHLKEENSQISYNIEDIGTVFNIGSISTDDPQGSFEFTVDTPDEDALFPMDLQFTVEFEEITDSDNSFGKVQVLDIVASQNEDEESLPFDLRENLATESYQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZZ1</accession>
    <name>G3AZZ1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_133580</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684958.1">
        <property type="nucleotide sequence ID" value="XM_006684895.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AZZ1"/>
    <dbReference type="GeneID" id="18249721"/>
    <dbReference type="KEGG" id="cten:18249721"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002993_0_0_1"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000558">
        <property type="entry name" value="EH domain-containing and endocytosis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="161"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="297"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="1270"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1192"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="641"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1311" mass="140465" checksum="FE6DF428306B677A" modified="2011-11-16" version="1">MSSSLQAPTLKVGLTPEEKRLYSQLFKSLDPEGTGVITGEKARTTFEKSGLPPAILGEIWQLADRNNLGFLTQFGFCYAMRLIGYTQAGNSPTPTLADTPGPLPKFAGLALPVAPAIVSSLQPQATNNSFMQSQPSAQVPQNTATYQSQPQDPIPPLNPTDYQKFSGLFVRTTGSPTKELSGASARDIFLKAKLPTDVLGQIWNLVDTENLGQLNMASFVVAMHLIQGLLGGSIKQLPPFLSDSIWQSAQPPPASSRQASYASVSSQSTVKHIPQQPPSYATQTSTPTDEWAVTPTMKSQYESIFANLDKAKTGQLNPDQVASFLMTSKLSQQDLAAVWDLADIQNTGVFGKLEFSIALFLVNRKVAGGSLPNIVPDGLIKAFGDDSASQTPTTYTSPVVSKATAPQQPPKPLTVQKTSIDELADVFGTPGPVTQVSPVATGSVPGSLQTRASSSDLTQSGELPKVRKNMNFRPTSSFGQSLLNKGGLSSPQEESPDLLGEDVHHGSPSKVPQPTSPPYVAAVQPEPPKSKTVNYDALRAVPPPPKRSTFQPQSTAGHTPPVQSPQELDRNLSSSSFVSPVPTGDINTSVPASGPPGTRNNDLLADPSTSAQFSQATSDIANISNQVKSLSSQTSQLHDNKSRATQELNKILTTKKEIESKLRILRTSYDNEVKQFKEVEGNLVNAKEETEALRSESSIAEAKFNALSTELNEKQVQMENLQKENGAVSERLGTVNAEISDLQNQLSIVLGENQKLSNQLSVRSSQVQVALVKKQDLESQLAQTLAANKRIQDEINAKAEEEAQALAHHQKLQNDLAEAKSFKPVQPEPKQSSSHFEGAIAGVVAGAAAGVGLGAVAKSILPDTQEPTTKSAEITEEEPTTESKGIATSSPSESKAVTSPEVSESVPQSVPVEALVDEVKEKAAPDFTGIEDNDNTEESKPETDSQYNKFDERTNTTIDSANSANGEGETPVTSPSPSEYQFPQGGMVGMPGVLVGVQRTDSLTSSVQNNAAMSVRDDNIEEFSDRDTIGVEEVANGSAAEEDKSAPSNQESDGDKLSSGVESFEIVNADDARDAEIDDKTRDSTSFVIKNPLTTDNAEEEFPPIKELDYDESDSSEDEDFHEAKDLSKGDLVAGSTAVATSKKDQFDSAFDDLEPAATEAEPEVVPGSFPVEDEPKDNFFDEFDNLEAAKAENEGEEEFGDNTDDFFNNDFTNSNMPDFSQSQQQPLTEAKTGNDEWEQLFAGFGNSQSAQNTPSQPVVNSFAPAAVSEPTNELVQELVGMGFDESTATEALQKEGWNLEAATNYLLDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3B002</accession>
    <name>G3B002_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Copper-transporting P1-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_102913</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B002"/>
    <dbReference type="STRING" id="590646.G3B002"/>
    <dbReference type="GeneID" id="18245590"/>
    <dbReference type="KEGG" id="cten:18245590"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_2_1"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000068">
        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="790"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="262"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1199" mass="132207" checksum="406FCC36E3B32AE9" modified="2011-11-16" version="1">MEHLEIYLRNIHCSDCEQTVRGIFASHYQLLDFRPSLPLSQQMSTTSAIYRQNRNQVDLYRSSHSPGASFEHIIKKITKKIKRAGFGVLSWEISVDGQLQQSSVDEADSENEPSSNQFNPVRGLYSKYKQKSFKKSHIQNCQKCRDELESEKEKRSDSSLNGSFTTVVETQQKEYRVVFFVGGMTCVSCASAVGEALGKAFQELHIESKHDEPSYSVNLLQHSAVAIVPNKQVINSLVNTILDSGFDCKILEVLPVERSINVKVTAAIGGITCSACAISIESAVHELPFVLDSNINTITKTGMFVMDDSDSNLESLKTTVEDCGFDFEVLNVTKINYVSGKKQSRTVNLEVEGMFCVHCPELVYDYLSSYGEVISVEDELTLSHPLLKFTYIPNQEKGLNIRKIIKDLNHLRSTDGDEAYTIDYSKQGPFTCNFIEPVSMDEHLRELAKKDVKTIALRLFLAAVVAIPTFVFGVVAMSLLPKHHAFRVWIEKPLWTGNVSRSTWILFFLSTPVYFFAADLFHRKAIVEVRSLWMHKNSFKRRLFKFGSMNLLMCLGTTIAYVSSIVLLILSSQQSSESMDALHTTYFDSVVFLTFFLLIGRLLEGASKSKTAEAISGLNKFKVSSATLVDRVPSGNNEYKYENDQTIDIKFLEVEDYIRIATGESPPVDCVIVENSAEFDESALTGESKPVKHSPGNQVFSGTVNVSNQAVIAKILSLQSDSLIDQILNTVREGQMRKAPIERTADALTGYFVPIIVFIGILVFIIWLILSYSGALPDSYLDVDIGGWFMWSLQFAIAVFVIACPCGIGLAAPTALFVGSGLAAKNGILVKGGGAAFQDAANTKVVCFDKTGTLTYGEIKVTDHQFCTDDEQMQSVAVQLARDLELSSKHPLAQAIKSFTSQFALTSNKIPAVETVPGKGLKGSIVAGDTDGFWNGLTGNVAILGNEALIDDYNVDISDEQKSILEEWKSEKKSVILVALLSEHKNQLLVMFACRDQIRHESKDIIDHLQNQLGIECWMITGDNCVTAQAIGSELGLDSEHIVSGVLPDEKQMHIKRIKGLRNTVIAMVGDGINDAPALAAADIGVALASGADIAVTSSDFILLNKSHPLTTLVTLFDLSTKVLNRVKFNFAWALVYNMIGIPIAAGVIYPYHNSRLSPVWASAAMAASSVSVVLSSLALNWYRPIVPKEQPKQAPEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B059</accession>
    <name>G3B059_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113043</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B059"/>
    <dbReference type="STRING" id="590646.G3B059"/>
    <dbReference type="GeneID" id="18246798"/>
    <dbReference type="KEGG" id="cten:18246798"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_1_1"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="145" mass="16952" checksum="C21BEF4CCB0A4A3F" modified="2011-11-16" version="1">MSLVVQEEGSFQHILRLLNTNIDGRIKIMYALTKIRGVGRRYSNLVCKKADVDLNKRAGELTQEELERVVTIMQNPTNYKIPAWFLNRQKDQVDGKDYHVLANQLESKLRDDLEKLKKIRAHRGIRHFWGLKVRGQHTKTTSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0C4</accession>
    <name>G3B0C4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113088</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0C4"/>
    <dbReference type="GeneID" id="18246819"/>
    <dbReference type="KEGG" id="cten:18246819"/>
    <dbReference type="HOGENOM" id="CLU_2190125_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833537" evidence="2">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="109" mass="10297" checksum="7F1E39E6102579E1" modified="2011-11-16" version="1" fragment="single">MKSSVFIAIAFTTLSVNAQNLAIRAASSGSVNASASEDSASEGSASARTSGSARSSGSARSSGSAARASDSSSSGGSSSSRESSSHGGVDSVTAGYGLSLAAVLAGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0C5</accession>
    <name>G3B0C5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Terpenoid cyclases/Protein prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_113091</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0C5"/>
    <dbReference type="STRING" id="590646.G3B0C5"/>
    <dbReference type="GeneID" id="18246820"/>
    <dbReference type="KEGG" id="cten:18246820"/>
    <dbReference type="eggNOG" id="KOG0367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_2_1_1"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="4"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="363" mass="40936" checksum="55B1A535F7908E87" modified="2011-11-16" version="1">MNQLLIHKHVKYFTLCLNMLPSKHQDQDNNKLSLICFCLEGLELLNGLGFSDVERAQFSDFIYNSYYTGNGFRAVMNPSGVYDIATMSSTFFGLQSLLVLRDTINEKVDRHSIMKFVQSCQWKTGPDKGCFAPTLNIDGTPFGDSDLRLCYMAVAIRRILKYDQIPPQQRKYDIDVPALIQYVLQRVNVSGGFSCVQLSESHSGFTFCALAMLKLLDYNLPEADSHQTLNWIVHRQVNHPEVLPGELELRHEDFGGFNGRVNKLSDSCYSWWSLGSLEILNHLDLSNLSAAAQFLLLNQDHRIGGIAKEFDSSPDPYHTFLSICSLALIKDKVDFEGNTQLSGLDVLLTAPTSAVEFLDSLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0J3</accession>
    <name>G3B0J3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_92634</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0J3"/>
    <dbReference type="STRING" id="590646.G3B0J3"/>
    <dbReference type="GeneID" id="18250215"/>
    <dbReference type="KEGG" id="cten:18250215"/>
    <dbReference type="eggNOG" id="ENOG502QRP5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010191_1_0_1"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0184">Conjugation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="622" mass="69285" checksum="61B2DD56953974B9" modified="2011-11-16" version="1">MIMEAPNYLDFKDRLAQVWCNRYSVILVVVLIKVYLFKQTLSEALKTLSQYSTEAVDEYNSASKKMQAVPEQYAAIVNSFVMSSINSIKSSSLYLILLFLKGLTEVLKFVVTLFLGTLICLISELVQGFADFAANVAEEVLSMINSIVKASTTIIQSAINGLSELVEDVSSGLNSVSNFFTGSNAVNATDFITKMDAAVSSLNNITIPSTVFDDINKLKTMVPDFDDLEDEALDSLTEPLTNLVDRLNVSVSFSLISSHNLNQTIGSQESATINSRVVAEFVDELESVLDHSFSVVLIVLVIASVGVMVPLAYKEYSNWKKKYKMYLAINDIGLRYRETPLEADEFRFLNIFNIYTNNVLYSLEKLGVRMNTKGIWLVSYCTSSYSIFLVGLAVAGLFTILLEYVLFRQFSSHLGRFPSETILNQASTSMSTNIELFVNNTNYFIQLQEAELNDELFGSFKNTSALIMASIDTFVQGLNSSLIEPFQDTPLSGPMSSVVYCFITRKLETIREGFEWVQNNLYISVPSLPDDISSDLTKLVNSSKPSVSADFNRYSSQTIALFQSTLFVELMFMVGVLAVWVVQLVAGIGLLVLRKRNVRIGDPKPLTAKQKLSYGLPFNELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B130</accession>
    <name>G3B130_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rh-like protein/ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_93101</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B130"/>
    <dbReference type="STRING" id="590646.G3B130"/>
    <dbReference type="GeneID" id="18250256"/>
    <dbReference type="KEGG" id="cten:18250256"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="18"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="521" mass="58556" checksum="B37D6CBBA66F8BD3" modified="2011-11-16" version="1">MISEESNLPIELAINSLYMLFCTMLLFFVLVGVSLFYSGLTQRRSALLQLAMPMLLTPFVLLEWYIWSYSLCYSSSSNHFIGDLDFAVLRQLRESAVLVYATPRGEILSINHFLFNGMFKIICVGFTFPGCIAERGRLLPMLLFLFCWSTIIYNPVTYWFWNRNGWLSTEFGTLPVTDFAGGNCIHVVSGFTALAYSYLLGPRNSKLLYNYRSSNNGFILLGTFFIAFGWCGFIAGCDYKFSTFSIYIMVNSLLAASVSSVVWMIIDFYYSSTPLDGNGHNKSERKISIISFSSGLMAGLVVITPAGGYVSSPTGFWKAIVFGVIGGISSNLATRLKFFFHIDDAFDIFAIHGITGIVGSLLTGIFGESSYGSKGGWVEGNFIQICYQILGCVVTATYVFVMSLLFLYLIDWIPGFHLRIDKTFNKRMREQKLSNTHLNVQASLSPTNNGFDHDTAVGSIDTKFEHGELEGGDQYELNGEYMMDFMEFIKVIRPEDYTEDYAGIEHIPSSNQMMDLNRKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B154</accession>
    <name>G3B154_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113642</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B154"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF36">
        <property type="entry name" value="PROLINE-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="36"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="539" mass="59489" checksum="7DC1B3B04E0F701D" modified="2011-11-16" version="1">MSKENKVEVVTSNLESTSNDDLDKRAELQRGLKPRHIQLIAIGGVIGTGLFVGSGAALSTCGPAALLTSYLIMSVVIYGVMLYLAEMATYLPLKGSSISTFATRYVDKSLGFAMGWNYWYSYNMLVPTEITAAGIVVKYWTDKVPVGVWITIFWLVIVGLNCLAVKYYGEAEFWFASLKIFCILGLIVTGIVIFFGGAPTHDRLGFRYWNEPGSFAQHLASGNTAKFLDVWTSIIKSAFAFIQGPELVALAAGEAKKPRQNIPFAARTFVYRVIFFYVLGALVIGVIVPYTNPNLLSGSGNGASSPFVIGIKNAGIKVLDHIVNAVILTSAWSSGNSYLYASTRSLLGLAREGYAPKFLDKTNKYGVPITIIPCAAFSLLAYLNVSNSSAEAFNWFSNICTISGLIGWVCLGISYLRFRKACSVQGIYETLPYKAPFQPYLTWFVIVFVTIVCITNGYAVFFDFNGSDFVAAYITLPLFFGLYFGHKIYMKVVHGYTRWYYPAEEIDLITGLAEVEAEDAAEPERIPKNFAEKVWFWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B166</accession>
    <name>G3B166_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_113649</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B166"/>
    <dbReference type="STRING" id="590646.G3B166"/>
    <dbReference type="GeneID" id="18247066"/>
    <dbReference type="KEGG" id="cten:18247066"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_3_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="113"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="368"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="423" mass="48386" checksum="371590649E062A01" modified="2011-11-16" version="1">MGHTNLNLLQKLHITKSAATQEVTQEVTVDSLNNVAAMDYYHSQQPHLPQQESHSTQPHGTQAPSMHTPVSVPTPVHVQTAQLPIDRTSEAIKRSLLPQRSTVSKGKYSLGDFHIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVIKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDSKNLFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVTLALEYLHSHDIIYRDLKPENILLDRNGHIKITDFGFAKEVNTVTWTLCGTPDYIAPEVITSKPYNKSVDWWSLGVLIFEMLAGYTPFYDSTPMKTYEKILSGKIHYPSFFTPDVIDLLSSLMTADLTRRLGNLMNGPADIRNHQWFSEVIWEKILAKDIETPYEPPITAGVGDSSLFDHYPEEQLDYGSAGEDPYFQYFTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1H2</accession>
    <name>G3B1H2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_121231</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685778.1">
        <property type="nucleotide sequence ID" value="XM_006685715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1H2"/>
    <dbReference type="STRING" id="590646.G3B1H2"/>
    <dbReference type="GeneID" id="18248834"/>
    <dbReference type="KEGG" id="cten:18248834"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
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    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="557" mass="60858" checksum="7C7AD5CF8F18B498" modified="2011-11-16" version="1">MEKDKKIQIRVMEVKRTELAERLGDAHISILPRKNLIILLCSMSLTLMLSFADQTGVTIGLSTIGKDLHCETTINWAGTASLLSNCVCQILFGRLSDIFGRKHVMIVCLFILSIADLCCGFAQTGIQFFIFRAFAGIGNGAVSSLSMVILSDVVTLEQRGKYQGILGASVGVGNAIGPFIMAGFIKSYSWRGFYYFVSPTMIANIAVVHFLVKNTKKENLDNILSTKDKLKQIDYLGIITAAIGLTLILVPISGGGSTFAWNSPLVIVMFIVGTLSLVGFVVIEWKIPELPMIPLHLFKVPSLCLLLASSFLFGMAYYGFLYYMPYFFNIVKQKSEVQSAVFLVPLVLCQAVGSIISGQIISRTGHYILTVIVGYSLWCLSNGLLILWSRTLPEYAEVLILIVMGTGVGFTFQPTMVAAQAQAKKSDRAVVISTRNVLRSFGGAVGIAVGSTIVSNSLLSEIATERGLSNLPDDYLEYLESNIYAKIEIKGLSAGQVNHVIGMYEKALRNYFYLLIPLIGVCLVSSFFIKDRGLQCIDEADQRKIVESSSSSVSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1H6</accession>
    <name>G3B1H6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113718</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1H6"/>
    <dbReference type="HOGENOM" id="CLU_1749397_0_0_1"/>
    <dbReference type="OrthoDB" id="4069694at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000992">
        <property type="entry name" value="SRP1_TIP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00660">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833528" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="149" mass="15966" checksum="31CFFF6CE67ADC74" modified="2011-11-16" version="1">MRLAFSTLLLALTSFASADHTTATSSESTVSVNSLDVEFLTKLVSDVSNHGAAYFMFSRTAGINIPKYFGSLVDELGSYSNDDYTTLLRAADFPITSVEHFATKLDWYSSRLAVSGINKKDETTSSDGAYKAFKIPIGLAVAAGMVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1I2</accession>
    <name>G3B1I2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_121249</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1I2"/>
    <dbReference type="STRING" id="590646.G3B1I2"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032568_0_0_1"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="248"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV64976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="593" mass="68599" checksum="BA23EE4400306847" modified="2011-11-16" version="1">MADPVPFYLQPYVENDRNEKFQWLTYGVVLIAFGLHGIIFHWIPIYLRKQRSESSNITPRYFTFLRGWELLNVSHKFTIPLLGSFYIQPSMFLLFAAYLAIMGVFSMSQVSDITYLPRLYVVAKRISKVSLSNLPLIYVMIIKNDLVTSLTGIKHDKLLFFHKWFSRTMFTMISIHVVLASRYWLHLGFPVMLVIPPQIFGFIAFGSFFLLNFASFKFIRRWAYDFFLVQHRVFSFIMLLFVLFHNSTNTTGAVVLSVHQLVIDNILCRIIAFVHTRQSPTKGKSTFEILDEDTVLVTVKLNAFPYSEMKWWRRFLPKWNTWKAGQHVYLTVPKVKWFQKHPFTIASISESGEMKFVIRVQKGFTKKLRNKILSKGAPAVDHEKNEENEDDDVVLKATFAGPFGAQYQPLITFDSVLFFGAGSGAAFSFPVCLDLLNTIQRRNSVHDYFGRNPSPLIKLVWAIKKSANVCWFRFVLDELAQYCQEGLLSIDVYVTQEKDRELYDISEGISVSQTGSSVTIYDVPNVKFHYSRPNIDGVIKHHVDHLKDGTNFRSMAVVSCGPLAFNHTIEKECQKQRWDMEAPDIYCYTESFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1M5</accession>
    <name>G3B1M5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92714</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1M5"/>
    <dbReference type="STRING" id="590646.G3B1M5"/>
    <dbReference type="eggNOG" id="ENOG502RQ1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098342_0_0_1"/>
    <dbReference type="OrthoDB" id="4008151at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="228" mass="27165" checksum="40E2DFB40F8834F1" modified="2011-11-16" version="1">MYTDTTMDPNAFYGLPTNYGWFYIPKKLYATDWTLPAVNEKIKQVYPDIESNAPSFQDIQDVIDDWCIEAKMATKPKPTKITKADKEELKHFMLYKSQLKPLMREQNRSKKRLAKEQDMMLRKSQKVQRAKERENAIEYVAKHGKFPEDYDFSQIKLTHAWNHYSAKFYKEAGASGQTKQNLSVQWKEMSKEKKEEYREEYIQHLKEGILYQRGELVPIKEKFKSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1P4</accession>
    <name>G3B1P4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113264</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685304.1">
        <property type="nucleotide sequence ID" value="XM_006685241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1P4"/>
    <dbReference type="GeneID" id="18246871"/>
    <dbReference type="KEGG" id="cten:18246871"/>
    <dbReference type="eggNOG" id="ENOG502S3HA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141740_0_0_1"/>
    <dbReference type="OrthoDB" id="4985585at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02228">
        <property type="entry name" value="cupin_EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="2">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="119" mass="13245" checksum="5B522B523C1D3967" modified="2011-11-16" version="1">MPMKYKPAVEGKAVKPPQIPSPGNNSFLGDIFTSTNEKDKQISCGFYKQEAGEPLVYTYDYEEMKVFLEVEGEYTITDETGYKVTVSPGDVFYFTNGATITFETTGYGLAFFTGLRPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Y9</accession>
    <name>G3B1Y9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_113329</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Y9"/>
    <dbReference type="STRING" id="590646.G3B1Y9"/>
    <dbReference type="GeneID" id="18246903"/>
    <dbReference type="KEGG" id="cten:18246903"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047421_2_0_1"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001086">
        <property type="entry name" value="GTP-binding protein GTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="38133" checksum="7A50D3634753876B" modified="2011-11-16" version="1">MEGMLLPNPKDSNATILLMGLRRGGKSSICKVVFHNMQPLDTLYLESTSKPTTEQFSSLIDLSVMELPGQLNYFEPNYDSERLFQSIGALVYVIDSQDEYLNAITNLSMIIEYAYKVNPKINIEVLIHKIDGLSEDYRLDCQRDIMQRTGDELLDLGLEGVQVSFYLTSIFDHSIYEAFSRIVQKLINELPSLENMLDNLVEHSSIEKVFLFDINSKIYVATDSSPVDIQTYEVCAEFIDITIDLDNLYISESPSNGASNGQSNGEPTCAKEVKSISYLNNGSILYLKQMIRGLALVASINNEDNDEFNNNLTLIDYNVNLFKSSLKKMWENSRIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3B221</accession>
    <name>G3B221_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SEY1</name>
        <name evidence="12" type="ORF">CANTEDRAFT_104397</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685393.1">
        <property type="nucleotide sequence ID" value="XM_006685330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B221"/>
    <dbReference type="STRING" id="590646.G3B221"/>
    <dbReference type="GeneID" id="18245716"/>
    <dbReference type="KEGG" id="cten:18245716"/>
    <dbReference type="eggNOG" id="KOG2203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011270_0_0_1"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="763"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="787"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="76"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="86"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="848" mass="98040" checksum="B7718AD321FE00B6" modified="2011-11-16" version="1">MSDTHRELQSRERSPTLPEPDLAASPSNSSHSSDSSFVPIDKQHLVDAIQVINEDKQFNDDLIQYIEKTVSLASIGENYHIISVFGSQSTGKSTLLNKLFNTNFDVMDESRRQQTTKGIWLAYCPMINSNKRLGKGNVENVFVMDVEGTDGRERGEDQDFERKSALFALSTSEILIINIWETQIGLYQGANMGLLKTVFEVNLSLFGKNKVSNKSDNHKVLLLFVIRDHVGVTPVENLASTVTQDLIKMWDSLNKPSEVETLKFDEFFDVQFHALGHKILQEDKFHDDIKLLGDKFVDSSSEDYLWKPNYHHDLPIDGWTMYASNCWEQIDSNKDLDLPTQQILVAKFKCDEIVNNLYEEFLVKYNELLNKESTKEFSHVDQVDFKEIGLLMRDLKSDYLEQFDLMASKYNSSVYEQKRHLLGEKIIGEYKELFSTYNKKLSNLILKEFKRELEKDLDGIENFIDKVNRLKLNTVSKLNDNLVLISIGEINFDDSTGTFIEELNDLISKQQVIELNAVITRLVKKLGTQLNKFIVFEVNSIGPESWDKIHNKFLDLIKASLSSYATRNGDYEFHLGISKETTNESITKFKFKSWCRFYQLIKKNLSKDNILNILKNRFEDTFRYDENGIPKLYNNEFELDANFNKAKSESLSLISFLTIVKLSDDSEILPEYDIFKEDLRKKYDEPVNFGDEDDEDPELDSNKFSHIISEIEKAEVLKKFKKEIDAKYIETKRSIVQHVTQIPYYIYIIIVVLGWNEFLAIIRSPVFFMLALLLGGGTYILYQLNLIKPAIQVGQRMVEEALTLGKQKLKELLLDDHEFHARNLEKMQGKTEEIELDDLTPQKTSPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B233</accession>
    <name>G3B233_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113368</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B233"/>
    <dbReference type="STRING" id="590646.G3B233"/>
    <dbReference type="GeneID" id="18246919"/>
    <dbReference type="KEGG" id="cten:18246919"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_4_1"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="22"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="405" mass="46894" checksum="36803162A43F1748" modified="2011-11-16" version="1">MSFFQDPNASSAALRKKKTLKKSINFSIMVIGESGIGRSTFINSLCGGNSIVPTSSTVDQDPFSKKLTLRHENVELEDNEGHKISLNIIDTPNFANSINCDDDFKVIVDFIRHQYDEVLLEESRVKRNPRFKDGRIHVLLYMINPTSHGLSEIDVKFLLHVNKLVNLIPVIGKSDSLTPEELKENKKLILEDLDSYGINHYKFNEYEYESDYIDEEIIEYNKYLNSLLPFAIIGANEFKPSNAEEDELLKLRVLNPLNSKPINIEMPEYNDFTILKNVLLITHLNEFKEITHEVIYENYRTEALSGKEFQYIDGERVSQPPSSKTDLESVSKDTTEDDYMLKEEQIKLEEERLKKFEERVHQDLINKRNELLQREQELKEIEKRLLAEGLKMNEDGDIVKIDAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2C2</accession>
    <name>G3B2C2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_120414</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2C2"/>
    <dbReference type="KEGG" id="cten:90982277"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="466" mass="52342" checksum="3C0623B054F9D8B7" modified="2011-11-16" version="1">MDLSDFSYVQWEPSTLASSITAWTSVNPAHTSGLEATLNSVISALPTATGYLDLVSYSQIYRGAEASMAVISAQEVLATATNSAVMAEASQAIFNNTLNLKKLDMDMNLYKYHLSVPANSIYFAIFTLVFLYVAGMSVISKYYWYNVTYICGYGLEFCGWLGRILAINDTSNNNFFILQFVALTLAPAFIMAGIYFLFAQMVVIHGREYSLLKPLWYSYFFISTDVLSLLVQAGGGASASIASKRHKNTKPGTDTIICGIVIQTVAMTVFLGFWFEFLNRVFFRHSGDVTVDSSFKKKSVKNFFKLLFNVKSTRAYKQDQLDPFYNPRFQHIRNSKLFGYMPLVITITVVVIYIRCIYRVVELSEGWRGYLITHEVYIMVLDALMVAIAGLVAIPFHPVWTLGRENVVRLATIRKRHDESSENQDELTSLQYSSNEAPVEKTVTAEKGITEVVLNKADNEVIADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2H4</accession>
    <name>G3B2H4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113467</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2H4"/>
    <dbReference type="STRING" id="590646.G3B2H4"/>
    <dbReference type="GeneID" id="18246972"/>
    <dbReference type="KEGG" id="cten:18246972"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_3_1"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="397" mass="42335" checksum="EA61D22E033EA410" modified="2011-11-16" version="1">MTKDDTTQYGFGTNAIHAGAPIDPHTGAVIEAISLSTTFGQSQPSKPIGVYEYSRSANPNRDNFEQAVAALEGAQYALAISSGSATTALLVQSLPVDSHIISGGDVYGGTHRYFTKVASTHGVTASFVPDLVDDLEAALRPNTRMVWLETPSNPTLKVTDIAAVKQVLQRHQDATGSRVVLVVDNTFLSPYISNPLAHGADVVIHSVTKYINGHSDVVMGVLATNDDSLAETYRFLQNAIGSVPSAFDSWLAHRGLKTLHLRVRHAATSALSIAQHLEAHPKVKAVNYPGLKTHANHGVVLKQHRDGLGGGMISFRIHGGADAASVFTSSTKLFTLAESLGGIESLIEVPAIMTHGGIPREEREANGVFDDLVRVSVGIEDTVDLLRDIDQALDKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2Q4</accession>
    <name>G3B2Q4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_103471</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2Q4"/>
    <dbReference type="GeneID" id="18245628"/>
    <dbReference type="KEGG" id="cten:18245628"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="11">
        <location>
            <begin position="80"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="583" mass="63986" checksum="8344E5AE91AC289E" modified="2011-11-16" version="1">MDITSSKKDELSTLTFDESRTSSSPYQRNPTKWERFKDSFKRYEEQSAPACEGYEELTDLEKANLKTANSPLKRELKPRHLQMIAIGSAIGSGLLVASGSALETGGPLAVLICWSLTGLSVFCTIHALGELTVTFPISGSFNVYASRFIDPSVGFAVAWNYFLQYLVLLPLELVAGSMTIQYWNTTINPDVWVLIFYVVVISINFFGVRAYGEAEFIFSSIKVVTVTMFIIVCIVIAAGGAPNGQAVGGKYWRDPGLFAHGFKGVSSVFVTSAFAYAGTELVGLTAAESQNPRVSLPKATKQVFWRILFFYMVSLTLICFLVPSNDPRLLGGTSSVDVTASPFVIAVVNGGINVLPSFMNAVILVSVISVGSSSVYATSRTLTALAEQGFAPKICGYIDNSGRPLVAIIITNVFGLLSFIAASNKQSEIFTWLMSISGLSSIFTWMSICLAHLRFRRALRYQNRTTDELAFSSQPGVIGSLYGVVLFTLVLIAEFWVSLFPLGQSPNAKTFFSNYLGFVVLVVFYMGHKVWSGNWTLFIRAKDMDIDTGRGENDLEALKAELAQERAVLQSKPLLYRIYHLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2R6</accession>
    <name>G3B2R6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_134055</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2R6"/>
    <dbReference type="STRING" id="590646.G3B2R6"/>
    <dbReference type="GeneID" id="18249760"/>
    <dbReference type="KEGG" id="cten:18249760"/>
    <dbReference type="eggNOG" id="KOG4347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003538_0_1_1"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="235"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="932" mass="107489" checksum="29F3EA356E119E73" modified="2011-11-16" version="1">MSFFENLRSKAVNTFNQVLDKNKGEKLSRDEKFCIDNHLPDGEVILAELAVELRISSEYSLIEYNSVPQGRVYLTNHYIVFWDAYDRRNCSFVLNLSAVKKVERVPTNSYGFALNLTTHSKLNIVLYLIGLRSESEKFAHSLKMTLKSNLPNIKKLQPFMQTCYSEYILAKNKISDENIEVVPPGGLGLIYKFPGNPKELRDKSKMKLWFDLFRADGRNLSLIRTNMFHKLIRVGLPNRLRGEIWELSCGSMYLRLDNPDEYERILEENKDKRSIAIEEIEKDLNRSLPEYSAYQNPDGIERLRKVLTAYSWKNPQVGYCQAMNIVTAALLIFMSEEQAFWCLNVLCERIVPGYYSKTMYGTLLDQRVFESLVEDTMPLLWQHIAKHDIQLSVVSLPWFLSLYLNSLPLVYAFRILDIFFQHGPKTLFQVALAILKINGEELLQLEDDGMFIQVIKNYFLSLDQSAHPDSPNVKYRSITKFQELLVTAFKEFSVIEDSVIEKHRNKHRDSIFSNISTFVKRTELRNLPRTPNLNQLTLGVVYDRFYSIVETYNVTLGSGKNTMDFEAFYRFMSEICDFMNNETTEDTRKIVRDFIHRLFSHWGTSSTSISLPELATGLDKLAEPDLMNAMSNFYELYTDSSKDRIDREGILKMSEDLLAITACWKDCFVLDEITQKEIENAIADVVYKQQKQQNEKQFESEKGELKLPTEVDIDKSIIESKQTERYLSAASTFIQRAFEYAQPNEEEVLIEDLKIEDNKITHNAALNPNAPVFLNLPTFRMVVLADETYELFFSKTLQNSVHADKPLDSKFDTMRNLRDMFDGLLADGREVATKVRRRMDSAASNALLANSDGASMKSGKSTRIQEVDEEERDDDFNTIALNDGDKDVLLGAEVGELKVTSNSTRPTTQVEQQKAHESEHEHESENLIEFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2T7</accession>
    <name>G3B2T7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_120716</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2T7"/>
    <dbReference type="STRING" id="590646.G3B2T7"/>
    <dbReference type="GeneID" id="18248798"/>
    <dbReference type="KEGG" id="cten:18248798"/>
    <dbReference type="eggNOG" id="KOG2228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007115_4_1_1"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001499">
        <property type="entry name" value="Origin recognition complex subunit 4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="429" mass="48516" checksum="F4EE76DFA44184B3" modified="2011-11-16" version="1">MDVPQTELYALMENTVRDHEGNSTLVIGPRGSGKTVLISQCLAQLEANYHGEYLVIRLNSFIHADDDSALREIAAQFARGLRSQGVESGPIETRQLTTTFSNILRILDNPDADDTMSIIFVIDDLETFTSGNKQILLYNLFELTQSSRTPICIIGTSTKFTTRELLEKRVRSRFSQRLVVINKFSQFDQFCQNCLNNLRLDQDQISTLENPQYGRQWNSHIDALASTDSCLRRVLSLNFNTSRNIKMFNNSAMLPVSQISTTSPYPLDSQFMGLIHNQIKNPIEAMFNALSPLELLLVVAAARFIEKSSLVTVNFNIAYQEYADMMKQYNIDKSIVRSSSVTTHNIPTNLKVNVKVWDPTVLKNCWMSLYRHGLLIDYTPNTAEGGKFTATSNRSFVLEDSRMLQLDLTLAEIGQLLPDDNGFRALTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2T9</accession>
    <name>G3B2T9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_113535</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2T9"/>
    <dbReference type="STRING" id="590646.G3B2T9"/>
    <dbReference type="GeneID" id="18247008"/>
    <dbReference type="KEGG" id="cten:18247008"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_1"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="99"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="528" mass="57756" checksum="5528FA99AD00424D" modified="2011-11-16" version="1">MSYDDIESATPDIVIGDSLPEEEYEIQYEHDVESDTEHIEEPEDEKKGKKSVSFAGIEEEFDEEQAKREFEEGGGLPEQPENPDFSELTPLSADIINRQATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKIYKCDNEDCPPPGCYRSFKSDKEIRPKCAVPGCPGTYKLVRHVSFVDCPGHDILMSTMLSGAAVMDAALLLVAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEHQKSILRFIKGTIADGAPIVPISAQLKYNIDAVNQFIVNYIPVPKRDFLASPRLIVIRSFDVNKPGAEIDDLKGGVAGGSILNGVFKIGDEIEIRPGIVTKDDNSKIQCKPIFSNIVSLFAENNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGAKGDLPSIYTDIEINYFLLRRLLGVKTDGQKGAKVRKLEAGEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEVNEKIALSRRIEKHWRLIGWASIKKGTALEPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2Z4</accession>
    <name>G3B2Z4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ethionine resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_104787</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2Z4"/>
    <dbReference type="STRING" id="590646.G3B2Z4"/>
    <dbReference type="GeneID" id="18245754"/>
    <dbReference type="KEGG" id="cten:18245754"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="587" mass="64249" checksum="3E49B77D0CB875B4" modified="2011-11-16" version="1">MSSYDQSNEFSHQFKHSDYERRNSVVYGSLGKGGLFIPKDFVTPRAIDSFVDENSVESDEQSPLIVAGPNHRRKSTIERDILRKEREVLKDNNIFVSSDTAAEDEDEEHIRRTFEEAVVANKIPVTTVSLELRHLLKSSIPLVLTFLLQNSLSTVSVLSVGHLGATELAAVSMGSMTANITGYAAIQGVATALDTLCPQAFGAKKYHLVGAYFQKCTALIFTFMLPILVVWLFFGYQLICLMVPDKETAKLSAVYLQYITPGIPGYILFECGKRFLQAQGVYHISTYVLFIAAPSNAIMNFYFVSKLGYYGAPLAVAINYWIMALGLLVGTVYFVKPEQTASGLHPLKCWNGLNVKEAFGAWDKLIYLAIPGLIMLEAEFLAFEILTLIASYLGTVALAAQSVGSTMASLTYQIPFAIGIAASTRIANYLGAGLAESAKKSTQVALSFGLVISAFNFIVLFTFDRQIANMFTSDERVIKAIEGVMWLIALMQVSDAVNANSAGCLRGQGQTKIGGIVNLVSYYIVGLPLSIYLTFYSPWKGTLDGLWIGSTVALTLIGVIQSYYALFADFNKLCEDARNRTGGDSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B435</accession>
    <name>G3B435_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_105448</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B435"/>
    <dbReference type="eggNOG" id="ENOG502SA5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133357_0_0_1"/>
    <dbReference type="OrthoDB" id="4092812at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="139" mass="15762" checksum="FD7AB4D637DFB780" modified="2011-11-16" version="1">MFVTLLILTVVLVGLVVLLPYWSKLVNYSYEPNQKSKARGRSGPSQLPQTSGYVPPDQQLQQETKAKATGLRKFTADDVPVKLKLNHLQTKRRKERLDVDRNPNNFDYDLDELINEVDEPISNSRTSNGESSVFSKDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B436</accession>
    <name>G3B436_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">37S ribosomal protein S25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113810</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B436"/>
    <dbReference type="STRING" id="590646.G3B436"/>
    <dbReference type="GeneID" id="18247127"/>
    <dbReference type="KEGG" id="cten:18247127"/>
    <dbReference type="eggNOG" id="ENOG502RZQQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081350_0_0_1"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029764">
        <property type="entry name" value="RSM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="247" mass="28732" checksum="4F0A628D58C5A1DB" modified="2011-11-16" version="1">MKIQSQAATVLERTSAYLKSGLLKNKPVWFDVVANHPPDRDLTRVPKTLLNSSYQDPMNRVKGNKTRLSDQELRTKNNKAHRIPKLKFVEDELRNLFYKRHPWEFSRPKVLIENEGNDNTQCDWSHMVQFNKPLDGESVVQRTMWLLKNSNRDLFESYDQARFEFYRLRMEEEMQSAVSREESGMFGAVFPTTNLQHGVQQEQVFVDDWAVLAAEKTTARRATAISKTAESKDATKSIFEEGEERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B439</accession>
    <name>G3B439_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF21-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_105118</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B439"/>
    <dbReference type="STRING" id="590646.G3B439"/>
    <dbReference type="GeneID" id="18245783"/>
    <dbReference type="KEGG" id="cten:18245783"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="64"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="329"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="71159" checksum="A1DB464CF7E94EC2" modified="2011-11-16" version="1">MSVKPSLSSYHARPVTLSGGSPVSGSILSRLMLVFTQMPKLVSALPIGIRSINHVKTQKHPALTAEQFYLNLAISATLVLLGGVFAGLTIGLMGQDEVYLKVMATSGDAHERKHARKVLRLIGKGKHWVLITLLLSNVITNETLPIVLDRCLGGGWPAVVASTASIVVFGEIIPQSICVRYGLEVGAYCSPFVLILMYVMYPIAFPIAMLLDHILGEDHGTVYKKSGLKTLVTLHKTMGVERLNEDEVTIISAVLDLKEKPVGTIMTPMDRVFTMSANTILDEKTVEEIFNAGFSRIPIHVPGESMNFIGMLLVRVLISYDPEDALPVASFPLATLPETGTDTSCLNILNYFQEGKSHMIVVSSHPGEPFGALGVLTLEDVIEELIGEEIVDESDVYIDINKNIKRTQPGPLAKRNLTSYLHTLYQRSSNGSKRNSLDNTRPSMDHPPPGDGGSPVHRVISKSEYQSRGGALLSNNSSILPALDSSKTWMPINPAANPLETSKSFVTIKRPDIEGVRNSVLQSPRSTPAHDEALDGPDYGVVHTTEEGAISHQKAISNNNGNGDHKFLLPSEREADISDFQHRLSLPENGEISHQKHYRTGGIIESVINVKGVHKTIIENVSDEDRDFEFDESEDRRLLGSRKNSTLKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B492</accession>
    <name>G3B492_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_121776</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B492"/>
    <dbReference type="eggNOG" id="ENOG502QYHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004492_0_0_1"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1205" mass="133954" checksum="94BDB668673626D6" modified="2011-11-16" version="1">MSDANSNPDNKTNFRFVEDVDWLLRDTAVTPTLANSSNVWPSPKSSPKASSLPGEVNPHLTTSISNSNDHVVSKTRPSVATIQEDSVLSSPALESSSRDRSNSNGVLSPSSPQLSSNSSTQGGFLSKIKTRFHRSPPMSPQMTTSGSSELFKDNFRLSRTTSNELSRTSSNQTTHTVASGNNTTGYGSSSTNGGPLSKISSWPSVHSGSSDPKLDEYVKFYSQKPLSRTNSRKSSISESASTTNLTDDERSGLSKFSFLRRRSSVSSASVPTAKLPLVSVATEYNRRPLTAVPDDDGTNYSAWLPKNWEEYKTPARVGTLQPILPEFKNLKPLKRVAFHSSTFLIDPPQQIPSRCPRRGNVEVLPNGTLKCHPLSEEDRKAMEKSHQGQGGGIVVGGTGALHFLEKSDKDKADEQKHDKDREKSEKDQAAAAGLPIIDKPIVHSRVGYTVPVEKMALDLMYTRCCHLREILPIPAILKQIPKDSMAPLPILQFRNPNPTMVEIQTFSDFIRIAPILCISLDGVNLSREQFKIVLSAMSAKTQLTKLSLRNTPLDPEGWSLLCWFLSRNTVLSKLDITQCPQLTVISTKPKKKKTQKEDELVRMTCNRENRTDMDWHLFIATIIARGGIEELILTGCCITDVDVFEKLVNRALSIKTNRLGLAYNNFSPMHMQVIFNDWLFKPFVRGIDLGFNDFSATNQYLKILLELHKQPDFAKKLEHSSLMFLSINSTNLRYCDDFKTILETVFLKLPNLKYLDLSNNPKLFATPESAKDPNEAVNYFVSKLPLFPQLVRLHLETNKLSPDAIVSLANVLPFCKHIAYFSLLGNKLDLAAAASLSHAVKNSKNLCKLEADFDDLPTYFKDRVGLYSMRNMENNIYHSNGGASEDNSHNEELAQQLNEILELKAAGELDLNSDIVRDFITKAKRIRTELRSAVNSMNNLQLKQQLSLEGKETLIRLIFIDSSIGKAMQLIDDKFSSEDMLYSFDGAESRNARRPTYEGDVEVPSISNGRSSPSSKTLFPPAISRTSSKTSLNHLDKEEGNMHRISSTINLAMDQMSDMSGDQIRKKIAGIDLEQLPAVIDFVQKLKAKGVDVTSVFKEIGKKKNDENDAADNSDNEDEGIDLGYITDKLKKLQNESPPSSSEDGKDSKESVSDPAHSKSNQEDFAEHTMTSTPMSMIDSKTLDASSGKEMNELYDEMLHKLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4H9</accession>
    <name>G3B4H9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_121570</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4H9"/>
    <dbReference type="eggNOG" id="ENOG502QS66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442765" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="7">
        <location>
            <begin position="40"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="332" mass="37311" checksum="67124AB08520C0C6" modified="2011-11-16" version="1">MGIISKIVFCCVTLLISMALMALKEKSLFATVKCKLPFPTYFISHGGPLLGDRNHFMTDKGAYDTLKAIGEEIIELKPDYLVVVSGHFQSDERDTIQISVNNAGKGYENKMIYDFYGFPDETYQQKFVSKSSPTLGLLVHEELTRSGFNAKIVDRGIDHGVWVPLRVAFGETLDIPLVEVSLPDSDSFSDSYKLGKALKNLRDELIWDPDTKKDIKGLIVCSGTSVHNLRDLQRSFSYPGQVMPYGKPFHELLQHTFEKSTPLTLAQNLNNLKKDANYSQLLYQAHPTLDHFLPFIVATGSNDGNSELETIYVNESFSLGWGMYKFNSRLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4I8</accession>
    <name>G3B4I8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="14">TC-AMP synthase</shortName>
            <ecNumber evidence="3 14">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_113868</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573</strain>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 14"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686572.1">
        <property type="nucleotide sequence ID" value="XM_006686509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4I8"/>
    <dbReference type="STRING" id="590646.G3B4I8"/>
    <dbReference type="GeneID" id="18247153"/>
    <dbReference type="KEGG" id="cten:18247153"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_1"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="32"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV64258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="377" mass="41231" checksum="66B26C32D4D20614" modified="2011-11-16" version="1">MSFDTKILKVNPETVVFKIGEDLPTITDPDTERNLQIAANELKNTSNVVGFPTETVYGLGGSALNDESVKSIYRAKNRPADNPLIVHVSSIDQLKRKLLPKDYIIPSIYSSLLEKMWPGPLTILLPVHEDSILSKLVTAGQDTFAVRLPSHPIARALIALSDTPIAAPSANSSTRPSPTLASHVYHDLNTKIPYILDGGSCNVGLESTVVDGLSHPPMLLRPGGISLEEIRRVGGPEWVNIILAKKVAGKNEAVRTPGMKYRHYSPSAPVILFLNCSDGEVAINNYIKKRDIADCKFALLRTRSFIPAKEISKTIIAERELGTTGGEISRNLFKMLREVDELGVDLIFVEGVDEIDEGLAIMNRLSKAAFETIIKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4L8</accession>
    <name>G3B4L8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_104587</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="GeneID" id="18245729"/>
    <dbReference type="KEGG" id="cten:18245729"/>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03369">
        <property type="entry name" value="ABCC_NFT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1187"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1276"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="328"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="672"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1009"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1363"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1642" mass="184087" checksum="98190344463A439E" modified="2011-11-16" version="1">MVESLSCPVWYYDDITVCSKDRYFNYLLPLITLCISAVVLAIKTSQSVLKRRKRIQLTDESRPLLAASSGVAKYNDDNDKDDIYKDIKSKHFDLTRLQNTDENGQPLGHYIEVPKDTTEKVRLVVEYLILACQLGGAVVVFFVPELHAEFGARNSIVRLVYWAYLFAIGSVRIINISKTHLRLPSLFAHTSVLNFFNLFPALLVFRSVLVKSYPTSVFVYYVINFVLSVSLFLLNFTSRFGDKPASVYVTNDNAMSSPETTSSIFSFISYSWIDKLVWSGYTTSLKMDDIWSMKGDDYSLSVLKGFEAAKSTTKFSVKVFSHFKFLFFLQALYAVLESFLSFVPTLLLKSVLEYVADPSSLPPNVAWSLVILMPIVKIGDSLVSGCSLFLGRRVCVRMRSVLIGEVYAKALRRKITVSKVADEKDEDAKSDKSIPEEDKEEVEEEKKTAELGAIINLMAIDAFKVSEICGYLHFFTGSILSVFICLFFLYELLGWSALAGAGILICLLPINYKVAIWLGNLQKKMLAITDKRIQKLNETLQSIRIIKFFAWEDKFFESIMKLRGEEIHQLFLRCISWAISSILWFLTPTLITLISFYCYTIIEGNVLTAPIAFTSLSLFTLLRGPLDQLADMTALVIQSKVSLDRVGDFLAEDETSKYEQLTNRPGPGSPTVGFEKATFVWNKSEEGSFKLRDIDISFKEGQLNVIFGPTGSGKTSLLLALLGEMDLIEGKVYLPGIIPRDELIVDPHTGLTDSVAYCSQSAWLLNETIKNNIVFGASFNQDRYDKVIDACGLSRDLQILSAGDATEIGEKGITLSGGQKQRVSLARALYSNSKTILLDDCLSAVDSHTALWIYENCISGPLMDKRTCILVSHNVALTVQNADWVVLMENGRVKTQATPSQLLESGALGADDLVKTSVMNSKNQSSSDLTALATKEARNTDLKAKSDIIDSKLKALNGAHTEEAEITDTIKADGKLVEEEQKAEGAVSSRVYIEYLKFFGSFQVWMVFLFLYGGSQGVYIFQSWWLRKWSMDSENSSSTSYVVSFAMSTIQPVYDGVKNNFVVQSLVSTTDAINSYKEENSSFFYMIVYGIIGMIYTIMASGRMLYTFYIGIDASNRMFVKVLTTVLGAKLRFFDKTPIGRIMNRFSKDIEAVDQELTPFAEYAFICLVQCVSTLFLITFITPGFLFFAFLISFIYYVIGLLYISLSRELKRYESISKSPIHQHFSESLAGIATIRAYGVESRFMKQNLSKIDTNNKPFFYIWVANRWLSLRVDSAGALVLFCAGVFVLLSVGKIDAGLAGLSLTYAIAFNESALWIVRLYSNVEMNMNSVERLQEYFDIEQEPPFEIPETEPRSTWPEKGEIEVEDVSLRYAPELPRVIKNISFHVNPKNKIGIVGRTGAGKSTIITAFFRFLDPETGRILIDGVDICKIGLKNLRQAITIIPQDPTLFTGTIKTNLDPFDEYTEAQMFEALRRVNLVSSEELQTAYNATASSSSSSAPEENVNQFLNLESSVSEGGGNLSQGQRQLMCLARSLLRSPKVILLDEATASIDYESDAMIQQTIREEFSNSTILTIAHRLRSIVDYDKILVMDEGRVVEYDDPYTLIANKETLFHSMCDNSGELDTLTKLAKEAFVSKKNAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4U5</accession>
    <name>G3B4U5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="11">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_121652</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="11"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4U5"/>
    <dbReference type="STRING" id="590646.G3B4U5"/>
    <dbReference type="eggNOG" id="KOG0042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_4_1_1"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000005">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000037">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="12">
        <location>
            <begin position="72"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="13">
        <location>
            <begin position="476"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="652" mass="71799" checksum="B5F71BF231F96BF5" modified="2011-11-16" version="1">MPTFSNILKSKLTQSALVGAGLVGGTVIYLDFIRSPNAPNLVNSYKPLIKSLPKPPSRDQLLENVENTKKFDMIVIGGGATGTGTAVDAATRGLNVCLLEQNDFASGTSSKSTKMAHGGVRYLEKAVFQLSKAQLDLVIEALNERGNMLRTAPHLCSVLPIMIPVYKWWQAPYFFAGCKMYDWFAGHQGLRSSTILSKETTSALAPMVDASNLKLSCVYHDGSFNDSRMNSSLAITAIENGATVLNYMKVDQLLKNSENKLEGVLATDLETGKQYNIQATSVVNATGPFADKILEMDNDPQGKPPATPQAPKMIVPSSGVHVVLPEYYGPQNIGLLDPSTSDGRVMFFLPWQGKVLCGTTDTPLKDVPASPVPTEEEIQDILQELQKYIVFPVNRDDVLSAWSGIRPLARNPDTLLNGSSGAGSTQGLVRSHLIHSSPTGLITISGGKWTTYREMAEETVDTVIKNFKFDKEIKPCQTNQLVLIGGEDYSKNYSARLIHEYRIPLKLAKHLSHNYGSRSSLILELYRQSDYNKLPITLAATKSFSPSEAVESEGNNLSYQNFDEPFTIAELKYSLKYEYIRTPVDFLARRTRLAFLNARQALSAVDGVVEIMKNDLNWDATTTEKMRSEAKAYIGTFGINSKDFDVKDFIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B519</accession>
    <name>G3B519_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-ketodihydrosphingosine reductase TSC10</fullName>
            <ecNumber evidence="10">1.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-dehydrosphinganine reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">KDS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_114429</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="10"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B519"/>
    <dbReference type="STRING" id="590646.G3B519"/>
    <dbReference type="GeneID" id="18247423"/>
    <dbReference type="KEGG" id="cten:18247423"/>
    <dbReference type="eggNOG" id="KOG1210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_3_0_1"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV63114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="313" mass="34746" checksum="96454F9EAF91DF77" modified="2011-11-16" version="1">MWFTKTHLPLENKLALITGASQGLGSELAAQLYEKNCSVVLVSRRANKLSEQVEAIVKKHGKKDTVTITYLAVDVCDYDQCVNMWKTLASDKRDPDYFFSCVGGAICKLFPDLTQAELSKGVQTDYLSTLYPVHAGVKQVIKSNETLERSAYKKRHIIIFSSAAAVYPLIGYSQYAPLKSALMSLSLTLRQELSPFNYRVSCVLPGNFQSEGFEEEEKTKPVITKKIEGASTPIAVDKCAQGILTSLDRGYDIVYTDLIGWVLGSASLGAHPRVLAFFQIIISLVFSMVAPIVSLFIDSDISSFFREQDKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B529</accession>
    <name>G3B529_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114438</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686915.1">
        <property type="nucleotide sequence ID" value="XM_006686852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B529"/>
    <dbReference type="GeneID" id="18247425"/>
    <dbReference type="KEGG" id="cten:18247425"/>
    <dbReference type="eggNOG" id="ENOG502QWBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="2">
        <location>
            <begin position="200"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38688" checksum="2ED2178040101658" modified="2011-11-16" version="1">MVEVLSIGLGGVGVIAAHALETSNENVHVTAVIRSDFDKVISEGYTIKQMAVGESAQREPSLEGYTPTHVVKSLEDAVALGPFDYIVVSTKAIPQTSNNVWDQVYELREKLIKTEDITSIVLIQNGLDIEKQWSKLGKSVNMISGVSYISSINTKGTINMWAPDAVTFGLFDPAAGNHSKLSQFIQLYTHSINSVEEDKNVRFTRMRKLLYNASFNTICCLTNSDVAVVFATDGVIDNIVRPLMKEIQLVANQDLKLHGSEQLLEDSHVEGMIKFTEETDVPFNYEPSMLVDLRNKRQIELQVILANLIQVYKQNNPEVDVKVSIPYINFLYYSLKVVQHKLAHGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B541</accession>
    <name>G3B541_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNK3P-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_122941</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B541"/>
    <dbReference type="STRING" id="590646.G3B541"/>
    <dbReference type="eggNOG" id="KOG2134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014938_0_0_1"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27743" checksum="7836A6F251C2348E" modified="2011-11-16" version="1">MNRRDIFSMLKHGKEAGKESVQAKPKIVREFHSSTIFSNNWKFTGTHLISNVPKDIQMPSSPVKIAAFDLDGTLVDTISGSKFARGPNDWKLWRNIDQSQSQVVPKLKSLVEQGYTIAIFTNQGGVLGVPQAKSYLNFRERVNSFVGHVQKDIEQFKPLVFASPKKPSAKKATLKVSPDEYHLVMRKPQVGMWNQLKREIGVEIDMENSFYVGDAAGRDTDFSDSDKVFANNLKIEFKVPEEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B557</accession>
    <name>G3B557_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_105845</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686935.1">
        <property type="nucleotide sequence ID" value="XM_006686872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B557"/>
    <dbReference type="STRING" id="590646.G3B557"/>
    <dbReference type="GeneID" id="18245844"/>
    <dbReference type="KEGG" id="cten:18245844"/>
    <dbReference type="eggNOG" id="KOG3495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187039_1_1_1"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="59" mass="6314" checksum="E6A62216D703FC16" modified="2011-11-16" version="1">MSAYKQAGISLNKAMSIAARTVRAALKPELKAGAERRGFTEAKVIKIEKGVQGEAKLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B594</accession>
    <name>G3B594_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114486</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B594"/>
    <dbReference type="STRING" id="590646.G3B594"/>
    <dbReference type="GeneID" id="18247443"/>
    <dbReference type="KEGG" id="cten:18247443"/>
    <dbReference type="eggNOG" id="KOG1316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_1_1"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="462" mass="51810" checksum="38A0E3B856E3FC75" modified="2011-11-16" version="1">MSKPTENRLWGGRFTGASDPLMDLYNASLPYDQKMYDADLTGTKVYTEGLQKLGLITSDELTAIHKGIEEIRNEWQTNTFEEKAGDEDIHTANERRLGEIIGKHIAGKVHTGRSRNDQVATDMRIFVRENLEKLLEFLSGFIGVLTKRARQEIDVLMPGYTHLQRAQPIRWSHWLSCYATYFTEDYKRLKQILVRVNQSPLGAGALAGHPYGIDREFLAKGLGFDSVIGNSLTAVSDRDFVIETLFWSTLFMNHISRFSEDLIIYSTAEFGFIKLSDAYSTGSSLMPQKKNPDSLELLRGKSGRVFGSLSGFLMSTKSIPSTYNKDMQEDKEPLFDALTTVEHSILIATGVISTLTINKQRMEGALTMDMLATDLADYLVRKGVPFRETHHISGDCVRTAEELKLSGIDKLSTAQFKEIDSRFEADVKEVFDFEVSVERRDAIGGTAKSAVLAQLEALEAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5D3</accession>
    <name>G3B5D3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 75</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114508</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687374.1">
        <property type="nucleotide sequence ID" value="XM_006687311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5D3"/>
    <dbReference type="STRING" id="590646.G3B5D3"/>
    <dbReference type="GeneID" id="18247455"/>
    <dbReference type="KEGG" id="cten:18247455"/>
    <dbReference type="eggNOG" id="KOG1508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31972" checksum="66430FD1FBDAF4C1" modified="2011-11-16" version="1">MPEDEEAKVIEANLLKLAECEKSMDQAEREAEIYRIKKTQGIFRDRRHILVNIPNFWYIILAENDDFSDYISVEDLKYLEYIADIYVHYKVTDGDADLKNPKDFSISITFKSDKELVPNQTVTKHFEVEVEDGEEKITSEPVEVQWPQELGTINPHLIKQRKGKDMSKEDKKNYRLGMKSFFSWFSWTGKKPGKEFRDGEDLTRLITDDLFPYAVKYYTEALPGADNDDADTSDPEELDLEDDEEEEEEEEEEDEDSKRKPEDQLGADSKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5G4</accession>
    <name>G3B5G4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II-associated protein RBA50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_123169</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5G4"/>
    <dbReference type="eggNOG" id="KOG1894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031074_0_0_1"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="274"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="50475" checksum="56DE784EF6233645" modified="2011-11-16" version="1">MDLVGEIVEKDVGEPTLPLPTDDLDIKKIEDIKKRRESAFTTRLKGRNGGPSVASKFKQNANSQLVSEKGLSEAEKIHKENMEKLGSMSAEEINQEREELLAQLNPDLIQSLMKRAEKREKHVEEPKHTHHEHRHAEGYGEWIGGMKTEFGVKDLTHLDKDDIEKALGISSLNIEDEEKTIKPPKKVRFDTNQEIAPDDYQLVNEDEGNDDVHFTKPKGTIKEYGKDLDLNDPEFYDQLHQKYYPDLPKETSKLAWMTEPVPVQKTSTYESISDMRFDFQGNLIELHAEQDQEKEIPTYLGLHHHSANPHLPGYTLGELVHLSRSVVAGQRCLSIQMLGRILHKLGLHKYNIMPISDDEQDKQFNESVKQLTRHFEKMMWDLIDELRVIESISEASDEKKSTNISVRNYAVEALWLWRQGGGRPKEEETTIDEEIAQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5K2</accession>
    <name>G3B5K2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_123234</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5K2"/>
    <dbReference type="STRING" id="590646.G3B5K2"/>
    <dbReference type="GeneID" id="18248947"/>
    <dbReference type="KEGG" id="cten:18248947"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049351_1_0_1"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44809" checksum="15975B4214B7CD97" modified="2011-11-16" version="1">MSFDPLSLFTPKQVDQVEPEVTVQHPHDDIFVQVSPDMAEEAEDYLIPIHILDLPMLKMKPPAHVLLLFLKLLAADEVWNFKQHQQNPRDSMALFQEKSVSLDLVHSSLAWLSSHSTRFNTMVKVGYLPMLSINLKKTNEYNDWLTRIISSDLKWLQKEEIDEIQKEASLRISENCGRTAQPDIIRKIKLDNMNQIQRDYLKLKEPSLTSDNLGLKTWGSSLILSQKLLNERSLLQEPILELGAGTGLVGIVCLLLGFKKVFLTDLEEILPNLKHNLLINQVDTEVEELDWNDPTGFLVKHSQINFKTIILSDPIYSSDHPALIHKVLKKFTGPQTHVLIQVPLRRNYEDVRETLWNLLDQSFTPIETSIELGADEFGDVEYCFKRLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5L8</accession>
    <name>G3B5L8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_106383</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5L8"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="519" mass="57965" checksum="EBF14FA69CDEFF06" modified="2011-11-16" version="1">MSFNDDILVEHANNQIFNEKPELSLSSISHYFGTRFSTLFDIPYKSQSSSVWVTMNPIPGLKQVDSRGWNFYFLGFLGWTVDAMDFFCVSATAPNIALTLNVSITQVTWGITLVLMFRSLGATIFGLASDYYGRKYTYILVCLLFVVIEIGTGFVKTYGQFLGVRALFGIAMGGFYPICATTALEDQPTKARGILSGLFLPGYNLGYIFAMAFFLAFEHTFKEGEGWRSLFWFSAGLPCILITWRFFLPETQTFIKLQEQKKILKEHDERAKVGIYKYLDKTIVTTIKTEWVLFIYLVLLMAGFNFTSHGSQDLFNTLLQKQLNIDSKTRVTIICVSNLGAIVGGLFFGQLNELLGRRLTIIICQIMAGAFLYPSFFSDHVPGIIGGYFFLNFAVMGAWGVVPIHLLELVNTNHRSFLSGVVYQLGNLASSASSTIEAQIGTQFPIGDKTGSYDYGLVMAIFCGAVFGYMIIIIILGPERYHRDLGIESDTNSIQRADDSEGASTVESKEVPEHVEQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5M3</accession>
    <name>G3B5M3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoin permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_135089</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5M3"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_2_0_1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="58818" checksum="85A673B590A8F400" modified="2011-11-16" version="1">MPTSKIALNVKTQPSSFSDGKLSSNASLDPIPIGSKDRKWKWPSMVGFWIAEAFSISMYQVASSAIVSGLSPGLSILAIFVGHIIISIPAMLNAYVGAQRGINFPISMRYTFGVYGAYFGVFVRGCVALLWFGTQTYQGGQAMALMISAIWPSFKHFPNELPESAHVTSSELLCFFIFLIVQMPVLFLTVNQLRYLFYIKIVFMPIFGLALFGWAVSSANGFGPLFHQGNRITDGTPVGVVFFRCVISVISPKATLALNIADFTRFATKPKQALWPQFVGLVVLVSLCGILGIVVTSAAYEVYGVLTWNPLEVSVLWDNRAAQFFSALMWSLAVIGTNISANSVSFANDLSLCFPKVINPRRGALICCVLSILTNPWQIQNSAASFTKFLGGYSIFLAPIASIMIVDYYILRKQVMDVHGLYILNGPYYFFKGFNIPAFIAFVCGISPNLPGLAWSIGSKNIPIGAVYLYSVSYITGFTVSGSIYYCICRYIPKLWMADIETVTDEIVSFECSSNSDITRPEKNVARFDEKDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B628</accession>
    <name>G3B628_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_130842</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B628"/>
    <dbReference type="STRING" id="590646.G3B628"/>
    <dbReference type="GeneID" id="18249482"/>
    <dbReference type="KEGG" id="cten:18249482"/>
    <dbReference type="eggNOG" id="KOG2114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001287_0_0_1"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="916"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1019" mass="117677" checksum="F2619D2E6D6E44EB" modified="2011-11-16" version="1">MSLPANWRQLQLFDVLPIRDPNFNTGDALYSSPTLSEIEATQNYMVITINGCFVKIISKQFTTSKSFMAYDTDFRISFLRSLPKSDLLVTIAEKQGSPSVLKLWDLNKLVYLEIDSSKEDPIDIVKRKFQTQVLIQNGDNSYPMSSFTFNADFTCLAIGYTNGKVLLVRGDLIRDRGAKQRLIYESPDPITGLHFNEFHELLYVTTTSRILTVPITGRNQGKPLNVLSKKTGVPLQCSVIDPGKQELIVGLDSSIRYYNQIGKSHTINFELRKKIIYRYTKNYLLMVSPMEDVSGSSRKMSTRVVMIDLHYKHISFSLTIPNVAINHVFEMWNDLYLLSSDGMLYKLHEKPINQQVELTLQRELFQLAYQLAKNSNLEVNVLLKICKLHGNFLYQKQDYEASISSYIKCLKYFTNENYVANDDEESLNDFIMTIITKFKDASNIHDLTEFLYQLYNLKIASNDHITLLLCCYCKLKQVDKIRGFIKEINLSDATNNADDSDINEGKKDFRNIFLDLDFPLIINLFKECGYFDEVIRLLYELNQPNLIVDIQLNDLKNPQRCLNYIQSLTIDDLLLVLIDHSKSLLDNLPIETTRLLINVFTGKYEPNQSTKILDSNNSKSDSSTTKEKSYERDEGMFPLNSYKAFLVYLSGKESEDDEMTISSLNGASEPTYLPPRPSLIFPSFINNPNEFVIFLEACIEAFDKYQGSTKDQKELLITLLEMYLSLSKKDKHNYEEWLNKAKQLVDQYSTLLDESSLLLVSHLYGVDGELKFTREEGFEETEFRTSQLSGDVKRCFEITKTYGNKKPQLYKMLLRFVISREEIFKQIDRQQFNFIINQLRTLKLASPLEIIQILGSTEFTTIGLIRDYLIETLDTAKQEITNNEKLVEYYEKESIKNSYKITELKTKPFVIQQNKCSACNLKLDFPVIHFKCKHSFHQRCLNDTYLSNNESLNATPTCSICINDIDSIQTLRDEQFRAKDEVELFESTLKESSDKFKVISNYLGKGVMENEFVQITNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Q9</accession>
    <name>G3B6Q9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gdp-GTP exchange protein for the Rho1p small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_122634</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Q9"/>
    <dbReference type="STRING" id="590646.G3B6Q9"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001251_2_1_1"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="187"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="4">
        <location>
            <begin position="559"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="875" mass="101100" checksum="FB3C47FC65CFF244" modified="2011-11-16" version="1">MSKKPSVYPAMLSRVARVFRESIFLTINTKDGLEYHDTFTGKMAVDIICRIIRTNDRNLALLLGRSLDSQKFFHDVTYQHRLRDSIHEVYAFNHIYSDSPISGTGVNGVFTILTDCYSPTCSRNSLCYSIACPRRLEQQARLNMKPQGGLQRAVSRLSLHDQDETKSLWHETVPKSVLDKLDKLEKMRQELIYEFIYTERDYVKDLEFMTDFYIMPLRNPSNNIIPEREREVFIRTVFGGVSDLLRLAKSISEALTRRQQQQKPVIQTIADVFLQFVDKFEPFIQYSGNKVFASFEHERQQQVNMRYASFLDAIEKRPESRKQDLSSFLIKGIQRPARYQLLLGGILKNTQPDSPDYPDLLKAKEEIEKILGKINIQTGESTDRHKIMVLHRLLGKQTLEDKYNFKLSYNNRIIYQVTLNRKRDNEKIDLYLFEHALLLVKHKIQNKREQYKVFEKPIYLPLLFVNSGYDIPTFRTVINSRINGSIMSESKAKVDSINTKLQINFMGLGSQQVHTTLNADDVANQNQVLSQISSQQKKIMAKYDIFSLSKYETRRFTGNNKINCAVPCYGGKKLLYGTDSGVWVSTVRTISITNNEKICSDPTLVISKEYVTQIEVLVEYSKLLVLSDKSLFEFDLSCTDSLDHAKNTRSGRLILSHVSSFKTGICDGKLLVCCIKQGNNHSINIFEPPNPFDKNKNRNKKYDIREITFSSDPISISFLRTRLCIGCTKGFEILSMEDGKKEPILDEADPSLDFATQKEIVNPLAIHRLGKDFLLSYSEFSFLINRNGWRTKHDWGIFWEGNPTNIALFYPYLLSFESNFIEIRDLKTTYLIRALIGENIRFLHSNEHEAMYACEEGGYDVIVSIDFLNLKPKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B703</accession>
    <name>G3B703_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Casein kinase II subunit alpha</fullName>
            <shortName evidence="11">CK II alpha</shortName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_114376</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Phosphorylates YTA7 during S-phase to promote transcription of histones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B703"/>
    <dbReference type="STRING" id="590646.G3B703"/>
    <dbReference type="GeneID" id="18247395"/>
    <dbReference type="KEGG" id="cten:18247395"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="36"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="327" mass="38429" checksum="34CE6E1A57BBD426" modified="2011-11-16" version="1">MTKFHSKVYTDVLASKPKSYWDYDSFQLSWNPTDSYEILNRIGRGKYSEVFLGVETTNGSYCVIKVLKPVKKKKIKREISILKNVCQGPNIIGVHDIVKNPASKTPAIIFEYVNNVDHRTLYPTLKDLDIRFYMLELLKALDYCHSMGIMHRDVKPNNIMIDHPQRKLRLIDWGLAEYYHPGTEYNVRVATRNFKGPELLLDFRYYDYSLDLWCLGCTLAAMVFKKEPFFFGKSNSDQLVQIVRVLGSEDLKRYLQKYNLKLAEEFDDLGFYNKKPWTKFVNSDNRHLVSEEFLDFIDKILKFDHQERLTAKEAMAHVYFDPVRNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7J8</accession>
    <name>G3B7J8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_109183</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687802.1">
        <property type="nucleotide sequence ID" value="XM_006687739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7J8"/>
    <dbReference type="GeneID" id="18246087"/>
    <dbReference type="KEGG" id="cten:18246087"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442799" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="492" mass="54683" checksum="3A4D8DD64CC36DC9" modified="2011-11-16" version="1">MVVLLDLVPIICATINGATMGVDQSMMNNLNIIDQYIEYFDLDANYEGLFSAAINIGSVVGGFFASQLIDLKSVGRKGGILISCLITFVGVALQTAAQNRAMFVIARIIIGIAVTVNAVAAPTYVAELAKPQNRGLVSGIYMSSWYFAAIITTGIALGTYTRSDSWAWRGISLWQITPSVLVLPLLAFIPETPRFLVYTDRPDEALKVLIRYHGNGERTPLVEAEFEEIRQTLQYEKESNIGWLDMLRTPGNRKRVWIIFWMGVFSMLCGTNIVSTYLGLFLDYAGITSTRKQIVINLTMQVVNLFFAIAGSYFTDGWGRVPILFWSTNLMAITLFLMGGLVKLYSDGHSTNGTNAVIFLVYLFSAVYSFSFTPLCVSYPVEIVNYSIRTKGMAFSQIVTFGFGFFNQYVIPLAMDAISWKFYIINACYNIVQAVIIYFSFVETKGLSLEEIDEVFDGVLHTDVRIGTAHYGEDEENVIVEAVDAEDKSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7N8</accession>
    <name>G3B7N8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_124631</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7N8"/>
    <dbReference type="eggNOG" id="ENOG502RF8B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099490_0_0_1"/>
    <dbReference type="OrthoDB" id="3999883at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442760" evidence="1">
        <location>
            <begin position="18"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="244" mass="27316" checksum="0FB1C2DD3F245E26" modified="2011-11-16" version="1">MPFELLLGAFMWPVIVARSVVYSPSKKITSFVPATVGLSESSNLSSYVVSKRFGSGSRIFDVYNTNNGAIPRGPVDPSEVLFWFLRSRLSRSAFRMYSSQTGSPQIGTKMEPMATIRAGFRSNILLISASKVPVTDLGWHVVHHDVDGIDAYRVFTLADGSTYQWTYKQKYLELVHNRGNFETEVRQRIGSVEIHGLNGFTLKVDESKIPLTLALASAWCSFIDMWSSKYSFGGVYWPDRSSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Q8</accession>
    <name>G3B7Q8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DDB1- and CUL4-associated factor 12 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_115761</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Q8"/>
    <dbReference type="STRING" id="590646.G3B7Q8"/>
    <dbReference type="eggNOG" id="KOG0265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_2_1"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23760">
        <property type="entry name" value="Beta-prop_DCAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="6">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="326" mass="35525" checksum="0E53C9B084B468BB" modified="2011-11-16" version="1">MSVVKKQKIANNLALSKVSDDVDSGKILYNRAVVLEGHQGPVYSAAINSELIVSGGDDKTINIWKLPTDDNDVNLGCIRGHKAAVTSVCWMNGNIVSGSADSTMAIWDGETGQKIRNYRNSTIINQVRYNGTLLASCDDAGTVKLWDFREKNSISTISTKFPVWTCCLSSSGNIFFSGIDPTIQAYDTRATDKSLWTTSSTIDSITSLDINNDNSMLVSRSTRGAVSTYNAKEFLPENVSRSSPYVYDGAPSGNEYKLIRACFSGDSSRIASGSDDKTVTVWDVVTRRILNKFEGHEASTLDVTFHPSENIVISTSLDGTLIVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7V0</accession>
    <name>G3B7V0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="6">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="6">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="6">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIF35</name>
        <name evidence="10" type="ORF">CANTEDRAFT_115122</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688773.1">
        <property type="nucleotide sequence ID" value="XM_006688710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7V0"/>
    <dbReference type="STRING" id="590646.G3B7V0"/>
    <dbReference type="GeneID" id="18247728"/>
    <dbReference type="KEGG" id="cten:18247728"/>
    <dbReference type="eggNOG" id="KOG0122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034595_0_0_1"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="197"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="279" mass="31207" checksum="57327283F6253B43" modified="2011-11-16" version="1">MSTQVINSWADAEDDVPAPEVTTNPDGTKTVVSYRQNQKGQKIRVTQKIKEIKVQEKVHPLVAKRRTWAKYGKEKNTPPGPDTRTTQLGEIVELKLGTQWKEMEKQEEEEKAQQSAQVISNQRIKCRLCGGDHFTSKCPFKGTLGDAGKDESSLSTADIVIDPSSPGAPSKFVPRHMRRDAEGNLPARDSSARDDSTTLRISQLNTLVDEHMVRNELLAAYGPLERVALVRNRDTGISRGFAYVSFATEQLAERALNDLNGKGYHSLILHIEWSKKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7V1</accession>
    <name>G3B7V1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_115124</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7V1"/>
    <dbReference type="STRING" id="590646.G3B7V1"/>
    <dbReference type="GeneID" id="90981632"/>
    <dbReference type="KEGG" id="cten:90981632"/>
    <dbReference type="eggNOG" id="KOG0283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011299_0_0_1"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="314"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="354"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="849" mass="94715" checksum="45BB0FD7ED9907CB" modified="2011-11-16" version="1">MTDHKSTPSTPSSTSRHSMISLKGSSPPGNSRNIFSKLLHRRSSTSSPIGPHSSSSTRASADISVQRSRSKRSDRSVSRTHSVRKADRSVVDDNDSLRSDETFNENDESDVSSVYSNLHHTGSTTFSEPLPGSSETSFEDVDRKLNELLVSGPAISESPWQGFNRDALNPPKYVKVMRRNKGSPKTVRRIFLAQELNDESDSDSVLDESPATSNMDLDGDAAANLDKAGEKPAEVDSSLSKEVFSMLFSRDGKYLAIAGRDSVIKVYKVLSSPLGRMEYQNHEEAHSKNKKKSKSQDEVYPYAPVFHQKPVRVFKGHTKSVLSIDWSKNNFLLSGSMDKTVKLWHVDRADCLATFQHEDFVTTVKFHPNDDRFFLSGSLDNYARLWSILEGSVAYGRNLGDEMLITASCFTPDGLHCLFGGFNGTIAMLETKGLHIIHSFDIKPGMPSLKPKTGKKVTSIQALVNEAHQDDDDLKYKWTYLITTNDSRIRLINANEKKLVTRFKGVTNTTSVEASISDDCRYILAGSEDHWCYVWENNNAIINNKLKSAVSEMLNGKRHLITDLESKHKKYYDFIIKNKLLKKLNAEQFLKDDQHSEFIANENSSYTSFHAHHSSVNAAIFAPSLTKKLLELSDDVVFDMIKRGRNCASADEFPKVNIPDQHEIDTGIAGFIMVTTDETGLIRVFRQDVAYDLRKGIIDYYKKSTRKECPTLTKSSRIVTKVKSPALSPSSSMSSVPNLVKHEPYLSTKRFDSRPPSKSISNGILNSQNGTFKIKSDAVIFEQNSQRIASSGVITPDYEPEVPFPSIKNSDSRSSVPLFVNTAVDSQTPEVMQFQTPVTSAPKTTTFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Z0</accession>
    <name>G3B7Z0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_124688</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Z0"/>
    <dbReference type="STRING" id="590646.G3B7Z0"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020992_1_0_1"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001151">
        <property type="entry name" value="RNA-binding protein PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="545"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="636" mass="68742" checksum="DB2C67751BB65E8A" modified="2011-11-16" version="1">MDLRNFTSNPNQLDIQRRPSLSSLSTTSGYGSSTYGANGHSNGATPQLNGHNSRTNAKNLSFGDINSSTATPNAWSSGENSLNDVAPWVEQQKQHQSKVGSLDIEKDKKDKKSEKSKDRNGDDGPKAIKDDDSFDDDHDDDLIPTAIVIKNIPFAIKKEQLLDVMTKLSLPLPYAFNYHFDNGVFRGLAFANFTSTDETSLVVNQLNGREIGGRKLRVEYKKMLPAQERERIEREKREKRGQLEEQHRSNSNASLASLMSTTSTTAATKNLSVNGSNASQPERLFMSLPSQTLTAPIPNDVNFNDIETLELYTQLVVFKDDNTKTIMELAYPPNLGIAQRKLLSSLCSWLNLLELYDNGLIIIRRKPGQSFQVLDIGPVTAEAPVAPTAAASSNPTGSMLNLNHLGQTNGMGSINVPGSIPPQGHGHPELLRSHSQSALPLPRLRQQNSTPIQGQFPQYSANSSSGSKSLYQSIQPFGFIPANQPNLLPTQLSSNSNFSPSTSAAAILRNGTTTSRPPYGDIRSTPPLNSFGTESPTPTPQQTHSSLFNPGSNSGSNSGTSPANPSSSQPSTPLQSHDINSRFAPFGQHPQAGGSLSSLPRHGDEFNDLSGKFNTISLNYDASTASNSGSGIWGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B803</accession>
    <name>G3B803_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_135637</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B803"/>
    <dbReference type="STRING" id="590646.G3B803"/>
    <dbReference type="eggNOG" id="KOG2950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024456_0_0_1"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="268"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="322" mass="37675" checksum="2A01A0DFD4479572" modified="2011-11-16" version="1">MSEEELEETVLGGSRRRRDKLKKSIRDEYSSDSSDSDQEPSKSPPTQDQQDSDSDMFASENDEKDSENPPTKKPKSPKKMDMSKFELEVGIDGIHEEEGSEADIEIEAFDLRQEEEEGYFDDDGNFVRHQELEDAQDIDDWVNADKEQIRKAKQAQEKHLATKTLTSITQTTAELLENLIGVLEPDETPMEALVRLAPAKRRRGKKNHNETNEDKHKKQLILKNQRSYEKAREELMRLYRRETGEDFKFNRGIKRPIDEVEQEDDFGDKIWEFKWDDSDEINGPYSEYEMGFWKNTYFENKVVVRRVGDMDFVHVSEVDFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B912</accession>
    <name>G3B912_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115898</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B912"/>
    <dbReference type="STRING" id="590646.G3B912"/>
    <dbReference type="GeneID" id="18248074"/>
    <dbReference type="KEGG" id="cten:18248074"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="158" mass="17606" checksum="0D3CC496A69F2FDD" modified="2011-11-16" version="1">MAALPRRIIKETERLISDPVPGITAYPDESNLRAFTVAMDGPDSSPYEHGVFDLELYLPDDYPMCPPKVRFLTRIYHPNIDKLGRICLDVLKDNWSPALQIRTILLSIQALLASPNPDDPLANDVAEDWKKDEAKAIGVAKEWTSKYAKSHTASGSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9J5</accession>
    <name>G3B9J5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94781</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688074.1">
        <property type="nucleotide sequence ID" value="XM_006688011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9J5"/>
    <dbReference type="GeneID" id="18250436"/>
    <dbReference type="KEGG" id="cten:18250436"/>
    <dbReference type="eggNOG" id="ENOG502S0GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266873_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1239" mass="138147" checksum="9CABDA87BAE1FE8D" modified="2011-11-16" version="1">MAGFSKPISAFRNGKTAPQKFITSPHLASEFKLYNIFTILDDLATVSGKTIRSANQHSRGCIGATADFQSYHYYAIFDGTSALAKYDGTLANQVDYFNFAAIFGKNGRCFGDIQSLVKSGDSISLTSDVDLYEFFTLFVKGKEQCSTDNSAHDFKSIFENHKTKRQQKIQNSNKNNKNNNPEENYYDFYNIFGKGREQYSTDYNFYNFYSIFENPKTQKQPNIQNTYKSHKYEKKYSLTADFNGFDFHNLFKQKSPAADFDDTGYELYTIFEEVECSLPKFEAVPEKPVEAHLPSSDRVVVPTQELVSFPKMKTLPKVELVLRKPEKAYLPKVDISMSKEALASLSNTDFLSEFGVGMKKIGNVYFPEHDVISFPKKVLKSLERLVPVPNLSSLPKVELALSEAEKAYLTKVKDLSSPKHALDSLSNLVSLPRVELMLKKPEKAYFPALELISSSKLDLKPLEKLKPLPKLTTLPKVELVLRKPERAYLPVLDSASLQDHALKPLEKLPSLPNMVSLSELEMRSEKLGKMYFPELDSLSKSIALANDDLMKLEKVSLPKLDSVSSAKIDLKPLEKLSEPEMDLEKLDKVCSSSKQTPASLPNLSSLPNVELVSKPKKLPSIQSPILDQLGKLVSLPKMNYLASLDMGLAKLGKACLSKIVNLSSSKRVLSSSPELAVLPKFDTLARPDSVYFPDRGFSKRDMDSISKGVLDRFEDSELTLLSRNYASVDVTGGVSTRLKFEGHKGPLGCSFESEALEFFPRFQYNGRLSATEGLIGSSFSLFLEAQWDNSVSMETISPPLASSDLSQSDAFQDDIVSIKNLSPSISESSDYSLDKEEALSQCYSLMEISPLSPEAGWELGDQYLDIRQTSEAKSGSDCLALNPSPLGNKVDTQKDASNDWILCLSPSIFDVPAFLSEALETEPLDSETLRNPVVIPAGYYELDGRSNIRYDFELDLRSSDNELSNGATDVGYARSNTHLLGYIPPLGSTDVSCSDGTDFSEDSVFETNEADDESSGTDYNSSASILEEDEGEEEEEEEEEEEEELQELVAIQPILSASLSILPPVVEESRFDIGDYDSYEEESSQDDRSQTPYSPSVVDNSTTGSPSFPEDQLLEDSIAGNSTAESDPRYFDRLREISPVDGPTLLISGQSVNLSSSDDFVRNKPPLRMPGNYRGVGRRQRNDLPDFNNLLYLNSYTREVALMDHKAPTELKEYRFYIGREPGEELEDNKAYHFTINSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAM6</accession>
    <name>G3BAM6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4112 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_107890</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAM6"/>
    <dbReference type="GeneID" id="18245988"/>
    <dbReference type="KEGG" id="cten:18245988"/>
    <dbReference type="eggNOG" id="ENOG502S45T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067862_0_0_1"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28264" checksum="369B7C90392A07E6" modified="2011-11-16" version="1">MLNYLIKSFLNRFFKLEYNFTVDDPYYEQVPINPQKNRFKKTPRRLPDNLSANDERLLKKFKTRAHRYDMAFSFIGVPFGTATIFQLVPVAGTIYTTYNSLQLLWLTRSFTNGFPIDLFLMCLLNILVDLLIGLIPIVGDLINIGFKANSRNYAIVRRHLFQISDYNNGIISKAAIRSNFVNNRFNWFKENEPVELKSLAAPLSSKSSSTTYTSTETGPVTRSRAARSVVSSATASTLGPEDIDLETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAR0</accession>
    <name>G3BAR0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Choline kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115538</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688257.1">
        <property type="nucleotide sequence ID" value="XM_006688194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAR0"/>
    <dbReference type="STRING" id="590646.G3BAR0"/>
    <dbReference type="GeneID" id="18247909"/>
    <dbReference type="KEGG" id="cten:18247909"/>
    <dbReference type="eggNOG" id="KOG2686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012712_4_2_1"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007521">
        <property type="entry name" value="Choline_kin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04428">
        <property type="entry name" value="Choline_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Choline kinase N-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="545" mass="62697" checksum="0465D2D81854D73C" modified="2011-11-16" version="1">MDITPASFSGTPRSRSRSRTRNSTANSRSTSSNRRPSLGSRRSLSSSSLTKLSVVPTNVDDAVVPSVQATLDNSLPLDFFKQDIWALIKTLKIGKWHKKQLDPKNIQVNRISGALTNSIYKIEYRDGYIKIPSLLLRVYGKNVDEIIDRESELEVLIKLCLKRIGPKLLGIFTNGRFEQFLEGFVTLTKEEIRHEVISQMLGRRMKDLHYKIQLEYKDYKDNVPMCWKLISKWLQIYETDLRQNFLQHGIKDEDIFLTEYEVFKAKVFEYRDWLFTKYERTGFASNFKFCHNDTQYGNLLLHESFNPGDIIVGEGTSTGVKNTSNKRDTSLVVIDFEYGGANFPAFDLVNHFSEWMANYHDPEKSYFLDESRYPTKLEQLNLIKAYIEYDFQYPSSNLKVDSEPDITKVTPAELIEFEIKKIYDECVFWRASVQVYWCIWGLIQNGPFKQKDIVEQLGATSLERGVDGTYTITTGLTSVELNESTIEDEITSADDEFNYIKYSQQKAALAIGDFISHGLFDQSSLSPQCQHLVKTLDSSVFGPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAY6</accession>
    <name>G3BAY6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_98697</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAY6"/>
    <dbReference type="STRING" id="590646.G3BAY6"/>
    <dbReference type="GeneID" id="18250796"/>
    <dbReference type="KEGG" id="cten:18250796"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_1_1"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="13"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="365" mass="39635" checksum="893F1131CB62080B" modified="2011-11-16" version="1">MITSHAVMIRQHGEPADVLFTQSYTIDDEHLAPNAVIVKVLASPINPSDINQIQGVYPSQPQKTTQYGTSFPSFVCGNEGLFEVVKVGASVTSVAPGDWALPLRVCSGTWRTYAEFSDDVLFKIPSPAQSTARGKTPLTLQQGAALTVNPLSAYLMLTHFVEPKPGNWFIQNGGNSAVGKFASQMGRLLGLNSISVIRDRPNLDEVKQQLHDTYGATHVITEEENNSREFSGVVKKWLSESGGSLQLGLNCVGGKSSTGVARKLQDNGIMLTYGGMSFQPVILPTSLHIFKNITSAGFWCTRIVEENLQLKKEILEKIISWYEDGELLEAASTASEYTGGDLASFYSERIADSKSGKQVVVNAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB43</accession>
    <name>G3BB43_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_125708</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB43"/>
    <dbReference type="STRING" id="590646.G3BB43"/>
    <dbReference type="GeneID" id="18249122"/>
    <dbReference type="KEGG" id="cten:18249122"/>
    <dbReference type="eggNOG" id="KOG2446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="549" mass="60679" checksum="A767F43C2226EA61" modified="2011-11-16" version="1">MSSFKLASELPAWKQLETLHKAIGQFNVAQEFEKDPQRFSKYSKTFENFDKSEILFDFSKNLVNDQVLDQLVELAKQANIEQLRDAMFAGDKINTTEDRAVFHVGLRNRALKPMPIDGQDTAPVVDEVLQHMKQFSEQIRSGSWTGYTGKAITDVVNIGIGGSDLGPVMVTEALKKYAQDGLDVHFVSNIDGTHLTETLKKCVPETTLFLIASKTFTTAETTTNANSAKEWFLAAAKDAAHIAKHFAALSTNAEEVAKFGIDTKNMFGFENWVGGRYSVWSAIGLSVAIYIGYDNFEAFLKGAEAVDKHFVETPLEHNIPVLGGLLSVWYNNFYGAQTHLVAPFDQYLHRFPAYLQQLSMESNGKSVTRANVFTNYETGTILFGEPATNAQHSFFQLVHQGTKLIPADFILAAQSHNPIRDNLHQRMLASNFFAQAEALMVGKSEDTVKAEGATGGLVPHKVFSGNRPTTSILVQKVTPASLGALIAYYEHVTFVEGAVWNINSFDQWGVELGKSLAKVIGSELDDGREVSSHDASTNGLINQFKKWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBB1</accession>
    <name>G3BBB1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115005</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBB1"/>
    <dbReference type="HOGENOM" id="CLU_2775713_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="69" mass="7657" checksum="24B94BFD0E0D968C" modified="2011-11-16" version="1">MTTGFQMPIVTHLCGDAQVHTMRCSPPSATFHHNRIEKLPDNRKGGVHQGFCVGLWVARCIKTSANPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBC7</accession>
    <name>G3BBC7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_136094</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688323.1">
        <property type="nucleotide sequence ID" value="XM_006688260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBC7"/>
    <dbReference type="GeneID" id="18249936"/>
    <dbReference type="KEGG" id="cten:18249936"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="547" mass="60548" checksum="BEFC35A93EC8A5F5" modified="2011-11-16" version="1">MLGQEKELDMRVPGTIHLVDLEGTMNVRHEEGDDIVLVPQPTDDPEDPLNWVKSRKRKLAFCLMLAVFSADILSTALSAVLLDIVADTGISLADLNTGVGIQYLFFGWSCLIWQPLGLNFGRRPVILFAGLACMLCTVWSAYVKSAGEWYVNRLLVGFFYGPIETLIEVCISDVFFAHERGGWIAWYCWTLFNIPFISGIVAGFISSRYGWQWIQFIASIIASGCLIILFFCLEETMFYRDPALELDAADSVPEAITSNIEDGSTKKDIVHVGIDKVNSSESSQPENNYKTKTFKDKLKLWGARSPQQKTNFFQSMWMPFYLLRFPSVVFAGFTVGAVLSWFNVVNATIASVLSAPPYNFGANMVGVFFASPAIGISVGAYFSGKVVDGFTVRKARTGKGYREPEFRLWLSVIPMVIHPFGCLLYGIGAAKGIHWVGLAFGLGAICSTFPIGSAIAINYIIDCYKEVSGVGLVTMILIRNTMGFGFSYAVTPWLEAVGTQNLYISLACIGAFFWALSLVMIALGKKFRKITATSYWKLVETYGLHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC61</accession>
    <name>G3BC61_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116146</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC61"/>
    <dbReference type="HOGENOM" id="CLU_2830972_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="66" mass="7670" checksum="B7467921F58A962B" modified="2011-11-16" version="1">MENSDLSVLVRASQELFKLHCGWTYCPRKQSVIISIENEEDFNEMVRQVSDILVCYSICLEFKPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCH3</accession>
    <name>G3BCH3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_111182</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCH3"/>
    <dbReference type="STRING" id="590646.G3BCH3"/>
    <dbReference type="GeneID" id="18246254"/>
    <dbReference type="KEGG" id="cten:18246254"/>
    <dbReference type="eggNOG" id="KOG3480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162151_0_0_1"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF18">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="106" mass="12331" checksum="F28AE6075EAD6AAA" modified="2011-11-16" version="1">MSLFLGGQAQFQNVDPEKIKLADIQFDAQNLMFKKLLSKCNTKCIAREYGEADLNTGEQSCVDRCAEKFFKTNRLMGETLQYNRQFNIQKMPDYQKVQSMLHQPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCL3</accession>
    <name>G3BCL3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_95650</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCL3"/>
    <dbReference type="STRING" id="590646.G3BCL3"/>
    <dbReference type="GeneID" id="18250526"/>
    <dbReference type="KEGG" id="cten:18250526"/>
    <dbReference type="eggNOG" id="ENOG502QUD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012168_0_0_1"/>
    <dbReference type="OrthoDB" id="5392646at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032741">
        <property type="entry name" value="Sls1_KH-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048748">
        <property type="entry name" value="SLS1_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14611">
        <property type="entry name" value="KH_SLS1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20777">
        <property type="entry name" value="KH_SLS1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 N-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 first KH" evidence="1">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 second KH" evidence="3">
        <location>
            <begin position="245"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 C-terminal" evidence="4">
        <location>
            <begin position="334"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="721" mass="82759" checksum="3EA7AB4D272EAE28" modified="2011-11-16" version="1">MFGLRTRTLATTARILNRGTSIDRIILDQLKDSSKLNKPSSFLILPSDHANMRMRDPRKRVINTKPQHPPQLKLASILLTDDIEEESTSSVIKLINNLRIYQNKVSDHSYKSVTSVLTKSFTSAQLKEYIRSYTSDPDYKGRKEGIAKKTKRQLCRIIISDLWNIQRSGKETSVEDFLTSRHVELQKKDLFLLLLNNGLLIRYLSRTGCKITFKNNTMSLRGTETQVSNANIILDYILVSSYQQTLDLSTIKRLFVQKFGDFDLNKLSSLFQIYFEELDNDHYRLSSLNQTQTQRAQRMLLWFLDYNSHIKQFVKIPSVYETKEFECLPFKEDESINWFNRLKSLFRLSSSPKNIFSSGFIDSQLKVFDDESLLNKTIDFEELNQVKSFLTPPEVNPQNSQPEAETDPLLNDSEISDLYNQLSQFPEDNHVVSKTQLVPPIFVITLGNVLFESTSKTTHRIPSADQDSLSSDKYIFNPSIPLLHDKVSTLPLFGNPELSLSDINEMRINDPHEYLVQLKFQPSLYDNESTDAPPVEVWINLNRFGKPEMNTLRVFTVENENTCFMPLPDKASDMKISSQLIGDVLKAPEAELEETSPDATEQTIESLLNETSEKYTKLKGQPGLETFLERSRLDFSGKVKPHIHETLRLQLSGKTVNYQYISTNYRRDLEFVYHGKLLQFSSIEGGSLGGRSSEVVLVGHDFDRDSLKELIEDSVAFINQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCX4</accession>
    <name>G3BCX4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_99722</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689445.1">
        <property type="nucleotide sequence ID" value="XM_006689382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCX4"/>
    <dbReference type="STRING" id="590646.G3BCX4"/>
    <dbReference type="GeneID" id="18250878"/>
    <dbReference type="KEGG" id="cten:18250878"/>
    <dbReference type="eggNOG" id="ENOG502S504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115063_1_0_1"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="84" mass="9203" checksum="DD3327BF579D644C" modified="2011-11-16" version="1">MKAVVSSGKAYFCTILSVFGVVILSVIAYLFQISHESMVGSTNDPENGPEVAKTVFGAVLVYLAFFLFCGFQVFLIQRESRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD59</accession>
    <name>G3BD59_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD59"/>
    <dbReference type="eggNOG" id="ENOG502SE6C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2885725_0_0_1"/>
    <dbReference type="OrthoDB" id="2122015at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007008">
        <property type="term" value="P:outer mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="69" mass="7900" checksum="9A1723C2EB16997C" modified="2011-11-16" version="1">MILNSIRKIFMSFRTEEEERLYSRAAFFNLLGFLGSCVAFSVLAQRLSRNPREIAHIARANALIRAIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDI6</accession>
    <name>G3BDI6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116358</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689523.1">
        <property type="nucleotide sequence ID" value="XM_006689460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDI6"/>
    <dbReference type="GeneID" id="18248263"/>
    <dbReference type="KEGG" id="cten:18248263"/>
    <dbReference type="HOGENOM" id="CLU_973178_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="286" mass="32670" checksum="4DEB52C97E8DE498" modified="2011-11-16" version="1">MVNAENEHELPSYSSADFAKMVQGPPGSLRFFRNRNGHFENVAASVSTKEAIELNKSKYFRGITSGSIGNSTLYSDRGKIKLHKEEVCDVILGTKGSTTARILTTDEDDIFYETSPVQECFDSIGTEDKPTMFPILTNGLIPDMNSPVEVIIEPTTKPLLPYNAMLDLSAINHNAKSMKVFGPLCNVIDYDPEELNDENALLNILNEEIVASMEAETENDHRSQSSDRSRIEEESWWYKVRSWFKEEEEAAFERYFNKYPWAKYFQRSLIENPISDLEDFENLFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDJ2</accession>
    <name>G3BDJ2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_116362</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDJ2"/>
    <dbReference type="STRING" id="590646.G3BDJ2"/>
    <dbReference type="eggNOG" id="ENOG502S7VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125051_0_1_1"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="111" mass="13448" checksum="3776FC7B5D7C9885" modified="2011-11-16" version="1">MKDPSKGSRVNGKSWKDEKGAFRVKSLGVTKQTAFTKRNAKRLQEDQYKTRLKDLKQEKEDAQKARITELKRRRELQAEKERYEMMATKMHKRKVERLKRKEKRNKLLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDV2</accession>
    <name>G3BDV2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pseudouridine-5'-phosphate glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_127580</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDV2"/>
    <dbReference type="STRING" id="590646.G3BDV2"/>
    <dbReference type="eggNOG" id="KOG3009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012201_0_1_1"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36398" checksum="83EFB5976F614F4C" modified="2011-11-16" version="1">MMKTIHHQKLAHITTRALSKTPSSSLPLIVSEEVQQALAQNKPVVSLESTILTHGFPYPENLSLGEQFEKAVRQEGGVPATIAFLKGVPHVGLSSSQLIELTENSKTAVKVSRRDIGHVMAKKLYGATTIASTSILSCMAGISVFGTGGLGGVHKEGQFTMDVSNDLVELGRNPITVVCAGPKSILDIGLTMEYLETQGVYVTTYNEFKDPIDTVEIPGFYARKSGIKSPNAFESFGEIADIIRHQRLMNLESGNLVCIPPPSDFAMDSGVIGKIIEDAYEEAKHLGIKGKEITPFLLLKIGEMTKGKSLDSNKHFVLNNIKCATKIASELTNVSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDV9</accession>
    <name>G3BDV9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Origin recognition complex subunit 3 winged helix C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116446</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDV9"/>
    <dbReference type="STRING" id="590646.G3BDV9"/>
    <dbReference type="GeneID" id="18248310"/>
    <dbReference type="KEGG" id="cten:18248310"/>
    <dbReference type="eggNOG" id="KOG2538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1019407_0_0_1"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="1">
        <location>
            <begin position="142"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="273" mass="31963" checksum="DF19BD0E3DE3D0AF" modified="2011-11-16" version="1">MLRHLPSFKKYIELLLQKHKQGLCEKSEIKMLLTDDHYLMKTFNNVKDQFVSFQSSIGATIEEIQHLSPNTDKFELYNLILSDRFHNSKLSKANKYKISNNFTTNTVFNEVFIISFHQCGQLPKLEENYDNLVLQLLRPNMRRILEQNMTDSAPYLDNELTRCSGSGNSELVMPKLFNLLVEAPSTVNHYEFFMAFKQSLNKDKVIKELKESIGKEASSRLTQILDNCAEDDKEWEKLIYSWFLSTCNELIMVGLFREKPRGDHFEKNIWKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDW1</accession>
    <name>G3BDW1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116447</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690338.1">
        <property type="nucleotide sequence ID" value="XM_006690275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDW1"/>
    <dbReference type="GeneID" id="18248311"/>
    <dbReference type="KEGG" id="cten:18248311"/>
    <dbReference type="eggNOG" id="ENOG502RR79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_966429_0_0_1"/>
    <dbReference type="OrthoDB" id="4012429at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="288" mass="33429" checksum="44309F59595A07BA" modified="2011-11-16" version="1">MYKSGVKALVRNASKRRPGLSQLRAQRDTFKPPQSVASSSTSSPPLKYVSVKEFPKAPSHVTSMDTKDLFESVNISIEPEKEDLSVNFEIPRKFSKQYQSSILNQRDLAMMKQLDVMMNTDDDKVIMESQIILGNLYSDRDSFSSYIPEHPLKKSLSGMINLNPHLNDIDDEYLWDLIPPDKFFGSKFYEKEGTFKEWEKEVMEEKNKLIDHLKVHEAEISDFLQKYGKNKSFLEKRNGRLRLNKSLIKAYKLLKSKNLHVKKMDGNDGEDLEFEFVIDDFDIKDNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE58</accession>
    <name>G3BE58_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_116517</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE58"/>
    <dbReference type="STRING" id="590646.G3BE58"/>
    <dbReference type="eggNOG" id="KOG1775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_6_0_1"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="97" mass="10315" checksum="F6BA25DEA0E7F650" modified="2011-11-16" version="1">MAEVATNPSVDVTGKQEEVTISTVLPLEIIDKSIGKVVTVLLTTDKEFTGKLVGFDDFVNVVLEDVTETDSEGNTDGPVKIMLLNGGQIAMISSTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEA0</accession>
    <name>G3BEA0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_99900</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEA0"/>
    <dbReference type="eggNOG" id="ENOG502T10B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104297_0_0_1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19551" checksum="BD45AA89F512E0BD" modified="2011-11-16" version="1">MSINNVVLKDNYSKLLGTSELPFVLASDGSEVIRFSSSSPRQSLSIVSKQSDNSVHINTKDGFIYLTTKRFIYITASQGDVSTFSVDLTLSPRLQFSHELKSPWFGPNYWEFIFFSTPTPSIASDGFPKNEYFKGQVKFNDGGLFQFVEVFNSILNDAVNNTQIDDQLPSYSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BED6</accession>
    <name>G3BED6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_116589</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BED6"/>
    <dbReference type="STRING" id="590646.G3BED6"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="170"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="329" mass="38439" checksum="5905919C7D2FDA14" modified="2011-11-16" version="1">MSKISAPSMGGFKLPLSDKGSFMRKASVFRSFVSADDPVFKPEAGRYHLYVSLACPWAHRALIVRDLLKLQDVIGLSIVHHNMDSKGWRFITKEPKDPKDLSEGTIDHVYGFERLSQLYYKANEGYEGRYTVPVLWDKKTETIVNNESSEIIRMLHEFKSVTGFDEDYYPETHQKQIDEINEWIYPYINNGVYKSGFAGTQEAYEEAVLALFEHLDKVEKILEDKYSSNKDSKFYYLIGDQLTEADIRLFTTIVRFDPVYHQHFKTNIRMIRHDYPFLNKWLQKLYWQKDSFKSTTDFDHIKKHYTQSHSHINPLGIVPVGPVPHILPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEE9</accession>
    <name>G3BEE9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116596</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689742.1">
        <property type="nucleotide sequence ID" value="XM_006689679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEE9"/>
    <dbReference type="GeneID" id="18248369"/>
    <dbReference type="KEGG" id="cten:18248369"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="73"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="567" mass="63002" checksum="BA0848EFB9BFE3A1" modified="2011-11-16" version="1">MTSVISIHSQLVEDHNQHVVHPPTFTSRAIKKYLKTRFTTLVASKKERSSYTWGQYFNPFRPLGELNRRQWMYFFIGYFAWTWDAFDFFSVSLNVDSIAIDLGKEVKDITWGITLVLMLRSVGAAIFGLIGDRYGTKLPYVVSLGLLVVLQIGCGFVKTYKQFLGVRALFGIAMGGVYSVALGTCYGCNPEPVKDLNQDYLSTINHDEVGISKNARGILGGLFQQGYAFGYLLVVVFNRAIVDNVNNDHNQAWRSIFWFSAGPPVIFIVWRLMLPETDDYLIKRAKMELRKRKIAEGNADPTAGPIQPTVREEIAEFVISGKKVLKTYWAMFLYTILLMAGFNFFSHGSQDIYPTLLKVQLGYGTDRATVTNSVANLGAIFGGFIFGHVSNFIGRRISIIIAAVLAGAMIYPWAFIKGSGINAGAFFLQAGVQGAWGVVPSHLSELSPPDYRTFVVGLSYQLGNLVSSASSTIESTIGERFPIVAPSGAPTYNYAKVMAIFLGCVVGYLIVVTLFGPENRNASFDIDRDEYVEEFDDHGIKSDEESLDEDHDNFSVTKPIEANVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEG3</accession>
    <name>G3BEG3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centromere protein S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_116603</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEG3"/>
    <dbReference type="STRING" id="590646.G3BEG3"/>
    <dbReference type="GeneID" id="18248372"/>
    <dbReference type="KEGG" id="cten:18248372"/>
    <dbReference type="eggNOG" id="ENOG502S7WI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100369_3_1_1"/>
    <dbReference type="OrthoDB" id="1872155at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10849" checksum="02306786E27DCB5F" modified="2011-11-16" version="1" fragment="single">MSKEEIESQLKSAVFLMVSRIVEQEVARLGVHSTPMFTASLVELTTNQLLNLGEDLEAFAHHAGRTTIKPEDMYMVVRKNETLAEILRQYEGKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEG9</accession>
    <name>G3BEG9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_137022</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEG9"/>
    <dbReference type="HOGENOM" id="CLU_1366077_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="203" mass="23144" checksum="82A9FB0A61DE7F3B" modified="2011-11-16" version="1">MILMQIPGKVKVKIRRIKHRHVGTHGGRRKGPPSYDDVLESKKLEIQSFETQSLTSAYDFQDKQTLNSIIDDKDEDFDLLPKFQDIIDESTEGTPHECDRGESLKVTDTGNDSLKDTGVSESVKSLIPTAASEVQPPSQVPSLHFSRPRFKSDVGKHQPHSMSTKHRAVMRNQKLVMLQHHQLRMVKLVVLIYMVYLLMGHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEJ0</accession>
    <name>G3BEJ0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_137034</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689769.1">
        <property type="nucleotide sequence ID" value="XM_006689706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEJ0"/>
    <dbReference type="STRING" id="590646.G3BEJ0"/>
    <dbReference type="GeneID" id="18250033"/>
    <dbReference type="KEGG" id="cten:18250033"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574940_0_0_1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="214"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="424" mass="47006" checksum="8E74AE7D670594AD" modified="2011-11-16" version="1">MPTKSKFTYKPMEKNSSINVKDLVDDMDNSSINIFKMYQRKHYLPYNKRISNMAWRIQNRKVLSSRRPSDPTCEDFDYVAHIRRIGQRDEFATTGARPINPSPPSLSYPHGGSNHGGSILSTSAGSAGTVSAAPPFKNSPPESLKSNRNFLSSYINSLESSLKNDYKLNDFDTASSAFPAAGPSTTSNSFQSITPPKSVGSKKSPGEEVAFGGPKKLLQCSNCQTKTTPLWRKSNNGDLLCNACGLFYKLHGVLRPLNTNSKQSPNQPIHPQQHSNLYNTLHGNAAKGPPPQAQQVPPTTNAGNLHSFSASNPFGNTLMNPSQGFNHFNDDHLSQSLPSFRNDSVISNTNTNLFNDLNLNPDMDLDKDDEIDRLLNMNLFQTDNFTIGLDKDGARKPEVLEMHDEIMTDPHDKQWNWLDFGPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEL0</accession>
    <name>G3BEL0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">CANTEDRAFT_116650</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEL0"/>
    <dbReference type="STRING" id="590646.G3BEL0"/>
    <dbReference type="eggNOG" id="KOG0313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000706">
        <property type="entry name" value="Ribosome biogenesis protein YTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="284"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="373"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="457" mass="50766" checksum="3234E6DD74212101" modified="2011-11-16" version="1">MRNISAMSEEKSQVKIKFITKEDESLAVSEAPLYVPISLKRYGLSEVVNHLLANDSESENPIPFDFLIDGKLLRTSLEDYLTKNALSSETFLTLEYTRAVLPPSYLASFNNNDWISSLDTINFSGKSKILSGAYDGVVRIYNMSGVIEKQFTGHSGSIRAVQWVSPTRVVSCGNDRQIRLWKNKEAGEIDDKADDEDPEEGTTIAILEGHKGPVVSLAVDSKINRILSAGYDGEVGFWSTNHKEMDKIQPLDYDANVLSSSSKKRRKMAVQDSTLRRRSPLSMLQSHKQPVEGITFDLTDSTVAYSVSQDHTIKTWDLVTSRCIDTRATGFSLLSVLHLPTKSLLVTGSSARHINLHDPRVKENDTELSVSKLVGHTNFVVGLSGCPYNDNMFASASHDGLVKVWDVRSVDPLYTITRNEPNSNSKIFDVRWDNEIGIISGGSDKKLQINKGSNLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEX0</accession>
    <name>G3BEX0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_115982</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689171.1">
        <property type="nucleotide sequence ID" value="XM_006689108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEX0"/>
    <dbReference type="STRING" id="590646.G3BEX0"/>
    <dbReference type="GeneID" id="18248108"/>
    <dbReference type="KEGG" id="cten:18248108"/>
    <dbReference type="eggNOG" id="KOG4209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1147054_0_0_1"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="62"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV59957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="242" mass="26194" checksum="03A216B1D31A52DB" modified="2011-11-16" version="1">MSEDTSMTGAEIVSQQPNTTVPDTFTDAETTTVPESTPIPAEPTPQTTETISPKVQEEVDSRSVYVGNVNFTSTPVQLEEFFHSVGVIERITILFDRFTGIPKGYAYIEFNSEEGAQKAISELDGKVFRNRELKVTAKRTNFPGMSRRARGSSGRFRGRGGYRGSRGGRGFVRGPGSRGRGRGRGRGGFMSVRGVLGNDDDGNGGPTEWNRGGRGRARGRGRERSLPDSQASTAPQPDSISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEY0</accession>
    <name>G3BEY0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_115988</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEY0"/>
    <dbReference type="STRING" id="590646.G3BEY0"/>
    <dbReference type="GeneID" id="18248114"/>
    <dbReference type="KEGG" id="cten:18248114"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_2_0_1"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="213"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="306" mass="33192" checksum="1CDC42586B221F17" modified="2011-11-16" version="1">MSDIGKKPGIQLYSKEYYAAGAIGGLIACGPTHSAVTPLDLVKCRRQVDSSLYTSNVQGWKTILRTKGDSIFTGVGATFVGYSFQGAGKYGFYEYFKKTYSDVVGKEYADKYKTGVYLAASASAEFIADIALCPFETIKVKTQTTIPPYATSVVDGWKKITAAEGIAGLYKGLTPLWFRQIPYTMVKFASFEKTVEQIYLYLGKPVSSYTPVQQTGVSFLGGYIAGIFCAIVSHPADVMVSKINSEKKPTESVGQAVSRIYSKIGFGGLWNGLPVRIAMIGTLTGFQWLIYDSFKVSIGLPTTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFD6</accession>
    <name>G3BFD6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116051</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689245.1">
        <property type="nucleotide sequence ID" value="XM_006689182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFD6"/>
    <dbReference type="GeneID" id="18248146"/>
    <dbReference type="KEGG" id="cten:18248146"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="252" mass="26973" checksum="479841D91BBB8F1B" modified="2011-11-16" version="1">MSTTYLIVGASRGIGFTYVKHLALNKSNLIIATARNENAAAKLEALGPNVKTILIDMQDPYSKFETSFKQLETLAPSGVDVFIQNAGISGPSCFAPPQEYEVDAYDEILAINIGGSAKSYKAAYPYIFKGEGTKKIVFTTSLLGQLGFPMAAQAYAVSKAGINHLGYQVALTNANSEDVLAKNSVTILLHPGIVDTDMTTASADNRDKVDASLFISQDESVTGTLALVDKLTSADNGKFFDYKGEELKYSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFP5</accession>
    <name>G3BFP5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein 78, mitochondrial HSP78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_126909</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFP5"/>
    <dbReference type="STRING" id="590646.G3BFP5"/>
    <dbReference type="GeneID" id="18249203"/>
    <dbReference type="KEGG" id="cten:18249203"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_1"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="122"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="523"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="696"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="336"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="794" mass="90004" checksum="AE5B57A5B1CAB1D2" modified="2011-11-16" version="1">MTITLTNIMSTMSIMRMRIMRMRIMRMRTMIMRITRYTITKPTTTPIYNLTGTLPTPTVLRALFSSSFPRNLQMSMNKEDSRPALEKYGQDLTQLAKDGKLDPVIGRDEEIRRTIQILSRRTKNNPVLIGNAGTGKTAIMEGLAQRILKGEVPESMKDKQIITLDLAAIISGAKFRGDFEEKLKSILTEVEQKQGKVILFIDELHLLMGLGKAEGSIDASNLLKPALARGKLSLCGATTIEEYRKYVEKDAALARRFSPVMVNEPTVQDTISILRGLKERYEVHHGVRITDGALVTAALHSNRYITDRFLPDKAIDLVDEACSTLRLQHESRPDAITNLDRQIMTIQIELESLRKEEDQLSIDRRKKLEDDLHVKEAELKEITDQWEAERNSIAEVKNAQTALEQARFDLEQTQREGNYAKASELQYAKIPELEKKLKELTAKDGAAPQANLLHDSVTSDDISYVISKMTGIPVTNLMKGERDKLLDMEVYLRQRVIGQDEAIQAIADSVRLQRAGLTSDKRPIASFMFLGPTGTGKTELTKTVAEFLFNDKNSVIRFDMSEFQEKHTVSRLIGSPPGYVGYEESGELTEAVRRKPYAVVLFDEFEKAHPDVSKLLLQVLDEGSLTDSHGKHIDFRNTIIVMTSNIGQEILLSDKNTSEDGKIEETVKQQITDNLRLHYPPEFLNRLDEVLIFNRLSKKSLRNILDIRLGEIRDRLIDKRMFLDVSDEAKDLLAQLGYDPVYGARPLNRVLQKQVLNPLSMLMIKGQVKDGETIQVDIKDNKIYVNPNHDPEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWB9</accession>
    <name>G3AWB9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112223</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWB9"/>
    <dbReference type="STRING" id="590646.G3AWB9"/>
    <dbReference type="GeneID" id="18246410"/>
    <dbReference type="KEGG" id="cten:18246410"/>
    <dbReference type="eggNOG" id="KOG3490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138052_2_1_1"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="112" mass="12652" checksum="8281A0779769DA59" modified="2011-11-16" version="1">MSSRSDRACMLCGIIQTYRKFVDEGCPNCESVLHYQDNDDNQIQDCTSPSFEGLVALGDDNKQSWVARWLRIDSFVPALYAVKINGKLPPHIVSDLLEQNVNYRPRDGSAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWN5</accession>
    <name>G3AWN5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase, mitochondrial</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA-splicing protein SPL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_112293</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWN5"/>
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    <dbReference type="KEGG" id="cten:18246450"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_1"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:tRNA wobble uridine modification"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Cysteine desulfurase IscS"/>
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        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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        <property type="entry name" value="Aminotrans_V_dom"/>
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        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002806">
        <property type="entry name" value="PRK02948.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="17">
        <location>
            <begin position="44"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV66578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="443" mass="48818" checksum="22F76DB2B25363BF" modified="2011-11-16" version="1">MLATTTLTPLEQTHVSTDISPPEGSGITLKNANRDDSEFGTRPIYLDFQATTPTDPRVLDKMLEFYTGLYGNPHSSTHSYGWETDKAVEKAREHVAAVIGADPKEIIFTSGATESNNMVIKGISRFYKKTKKHIITTQTEHKCVLDSARHMKDEGFDVTYLPVTPEGLINLDDLKNAIRKDTALVSIMAVNNEIGVIQPIKEIGQICRQNKIFFHTDAAQAYGKIPIDVNEMNIDLMSISSHKIYGPKGVGACYVRRRPRVRIDPIISGGGQERGLRSGTLAPPLIAGFGEAARLMVQESAYDRKHIDKLSNKLKSALLSIPDVYFNGPADVSKHYPGCVNCSFGYIEGESLLMALKDIALSSGSACTSASLEPSYVLHALGADDTLAHSSIRFGIGRFTTEDEIDYVIEAINQRVDFLRKLSPLWEMVQEGIDLNTIEWSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWP1</accession>
    <name>G3AWP1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112299</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWP1"/>
    <dbReference type="STRING" id="590646.G3AWP1"/>
    <dbReference type="GeneID" id="18246455"/>
    <dbReference type="KEGG" id="cten:18246455"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_1"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000092">
        <property type="entry name" value="Type II HSP40 co-chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="332" mass="36006" checksum="6E5F8776069C333F" modified="2011-11-16" version="1">MVKETKLYDILGVAPSASESELKKAYRKAALKYHPDKPTGDTEKFKEISEAFDILSNSDKRQIYDDYGIEAARGNAPAENPFAGGGGGGGHPFAGFGGPGGHSFSQNDAFNIFSQMGGFGMDEGGFSFGGGMPGGYGGGGMPGGFGGASRGGASRRPEPDTVTMPLGVKLEELYNGCVKKLKVNRKDPNGTRNSKTLEVNIRPGWKAGTKITFKNEGDYQPECQARQTIQFVLEEKPHESFIRDGNDLKMVIPLTFKESLCGFDKEVTTIDGRRIPLSRTSPIQPSSVNSYPGLGMPITKSPGQRGDLHISYKIDYPHYLTPEQKQIIQQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWS5</accession>
    <name>G3AWS5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_96620</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWS5"/>
    <dbReference type="STRING" id="590646.G3AWS5"/>
    <dbReference type="GeneID" id="18250619"/>
    <dbReference type="KEGG" id="cten:18250619"/>
    <dbReference type="eggNOG" id="KOG1962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087648_0_1_1"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="206" mass="23138" checksum="A6843B47836A724F" modified="2011-11-16" version="1">MALYYNLVFGLLVVEVAFFTVLSLPYPRKIRRTVLTTVSAPFRNEKFQIALKCILGFVLVLFIDSVNRVASVSNELQGSAIRGSAIVNDRSEIQARRFYAQRNMYLCGFTLFLTLILLRTYSLVTELLVTKDKVDALTGESELGETETKDSPSIVKLKEELAAKDKELESLKEKAKALANDYEGDEDIKTKPATDDSDSKLRARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWX3</accession>
    <name>G3AWX3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112351</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWX3"/>
    <dbReference type="HOGENOM" id="CLU_2885558_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="63" mass="7261" checksum="7FD7C84302D9F1D9" modified="2011-11-16" version="1">MYSYPKYPLHSELCYCSQPKSNLQQVRTSSTTLDTNTAKDLNSTPVNLQPNTNFWKTPFVFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX02</accession>
    <name>G3AX02_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112373</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX02"/>
    <dbReference type="STRING" id="590646.G3AX02"/>
    <dbReference type="eggNOG" id="ENOG502S416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142363_1_0_1"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833533" description="Long chronological lifespan protein 2" evidence="4">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="128" mass="14452" checksum="6495B780488A893C" modified="2011-11-16" version="1">MLSWILTTLTLVLVVQANFFDFVQNQFHTNNQGAPAPAGTFEMGVLNSNCKDYLCPETQTCVQGPRSCPCPFPSSQLRCVLPDGNYICISKPAGDFSVRYKDPQTNWKIDANDDTIRDCGWVNRHYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX17</accession>
    <name>G3AX17_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_132921</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AX17"/>
    <dbReference type="GeneID" id="18249653"/>
    <dbReference type="KEGG" id="cten:18249653"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000709_4_2_1"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="770"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1182"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1501"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="522"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="948"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1403"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="972"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1246"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1422"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1455"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1626" mass="180282" checksum="FBAD8D2336179CB4" modified="2011-11-16" version="1">MSKDDFFHQPLFQLSQTNLRDLERSVSPREIIPNNSDVSDLPQSNARFNDLIQGQIDLSLASSNNPTTVLELDLDGNIKYLSKNWEIIVGTKVKKMIQKPISSFIIGNNEDDLNVFNYAIEKMIKDDDSYKIQFITATDDKSIPDYEINITPNNSVEESETENDLQREYQPIGGFSSPLSFTENVVQHEDAIDIDDMDDEVETAGSDTSSKVSNNGGIIELEAQGILIHDSKTHLPTHSIWTIKPYVPLDLDLTIPSQLIDLLGFGSTIFENYLLELKESKTADETSVPQPQTVLCHICEQQIPAWFLEKHSDLCIVEHRTSEDLQLCHDLISDQKELILRIFESLYQQNVNNYSYAYNQVNSSSSSLGSSISSSSSVSSAVLDYKGLPLPNSSSNEQLNVTHFQSKPVLPIKKFPFGILSRLIELCDEALAINPIEINQNGEPRFSPNTEKSISMIVNFKPFETSDKAIKLIIQDTQSLINDKIDTLSRLYSVLKISEKIKKEVDELVLASVTDTVSRIKEQMNSSKSNSNSISNSTLNSPIDLNSPIHSGKLTPSSSRFSPRPSQARIHSPQPLKSPRTTSPQNLQPPPIITASSSEDSSNSPNYPSITPKDILLRGRSSNMEFSRSSNSISSLSSPRSRRNSKDITIEGFNELVLTKHKTSDSDHSSPMRSSPATVSSMPIPNSNVNIGHNHFYSPGHNLSSLQRNTPSSSPLISHSQIHNDSLERPDKAYLNISGTSKTVTKPPLSPLLVSQTPATKPSAGSIKDYEIIKAISKGAFGSVFLAKRKLTGDYVAIKCLKKSDMVAKNQILNVKSERAVMMKQSDSPYVAQLYSSFQTNNYLYLVMEYLNGGDCATLIKMLGTLGVDWTRRYVAEVIVGVEDLHKRGIIHRDLKPDNLLIDSTGHLKLTDFGLSRMGVIGRQRLQRKSSSSEHGVELFRRSLASTVTPGSPRLSFDGPVFEASNGGKRASSVTPFSLSPTVDQRNSISSPLSETRQTESRISIDQVPSESRSEPQSSDRSKKYDSPNLNPSLPRTSSETSFAIVEDDFHVSPSQSAKVTSYKLYDPQETSEIKFVGTPDYLAPETIRGVGQSEASDWWSLGCIMFEFLFGYPPYHSSTPQQVFTNILNGEIDWPKLSEEDFDEICPPAAKNLIERLLNVNPEDRLGYGGSDEIKRHQYFNGIDWDNLFNEIPSFIPQLDDPESTEYFDKRGADISQFPKDESESSDEDRGSNDDMKLRIRDDNLGSGTSESKGTTSTNSSSNSRRGSLSAGTKRERRSSKLTDPSEFGSFYFRNLNVLEKANKDVINRLKSEHLEHRGSFSSSSSDSTPIRSRGYSFGEKPNFSLNLNNSGSVGLGLASSFGPGSSSSTPVSATNSASGYFGPPLKDASPFKRPVSPMLTAFNRAPSPMKDLTGSPPSFKQHERIGSGHSSDDIPDFGKLSPNDPPAMRHRSSVNSLARNSFKDSPTSSDTEDNSRALMRVQKRRESSRRQMMNINELDILYCEPIPIVRHVIMNYFEKLGCIVVLVNDGDELIRRATGQVKFDMIFTALKLPKIGGIDAVKLIRHTNGVNSQTPLVAITSFAKEATQSGQFSEVLEKPVEFECLRQCLARSRSDEVFESDTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX46</accession>
    <name>G3AX46_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_91857</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX46"/>
    <dbReference type="GeneID" id="18250119"/>
    <dbReference type="KEGG" id="cten:18250119"/>
    <dbReference type="HOGENOM" id="CLU_387314_0_0_1"/>
    <dbReference type="OrthoDB" id="10654014at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="713" mass="81540" checksum="C216DE15E215C2D9" modified="2011-11-16" version="1">MTQLHRLCIGWGLRRGFSSIPSNSNQVISSILQLARVSPNHQWKQMVSTSDDLASLPKLEIPKPQKMHFRGSLHMDTPSEDTWSKICVYGVVNNLYLQETYKLGQKIIDFVPIAYRTLNNPHMSSKFDRSVTRDLMAWRPPPSWKKKFKESGIKTRPSVQHVIGFNFIQNPLSCLDNLFGSLGSDTAYNPDMTGFLGDILQELESLDGSQVALNPEYLFHQGTEFTLPPLGDASPVVTTLLVNSSVVGPRAREPLSTSMALEHYLTLVSRFGSSLYDILVRRSILVHSRGDHFSTLYYMLVSSEYVQFLVETSRVFNKLIESKQMVDSIIKNSARDLYHRQLGQYFAVLAFTKPQDTVDWCSTHVKNYIDIFDNLTDMEIKQFTKDFSTTLRFSSTSIDRVELESMRSYLKRIQVPEPPSQDQEECRAIAVDCVSVASYKATIVNSFEILTKRRTLVLQALEEYPGILSSLGRLVQINESEGIRQVTTMVSGMLQRPSEELDLTRTLGNFRFEDFGLLESEIPGASHLANLLAVNYHISRHYLKETECSPRERSKYCSIMQKYSQLGYSFYRYNVLLWLADSQLPIKTQIHLQQKLLSKTFKTLVYNNIKTPTDPVYMEMVKARASNRYIKLKLGQTGFDQYMGLLAITNQEEYVKKWINNCVAAIKQAPSATEFPQLLPQKPYDFVQTDTNPELDLEESFDFVLTGYYDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX49</accession>
    <name>G3AX49_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112428</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684135.1">
        <property type="nucleotide sequence ID" value="XM_006684072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX49"/>
    <dbReference type="STRING" id="590646.G3AX49"/>
    <dbReference type="GeneID" id="18246515"/>
    <dbReference type="KEGG" id="cten:18246515"/>
    <dbReference type="eggNOG" id="ENOG502T4TP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082179_0_0_1"/>
    <dbReference type="OrthoDB" id="4085072at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833535" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="4">
        <location>
            <begin position="50"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="236" mass="26313" checksum="FB842BF330EC7F05" modified="2011-11-16" version="1">MKLGIFLTAGLSMVQAIYALSLQGKIVGVLPEYKLQNAEQIVNGNNLPIRFTVELTSIDGEISHKMRALVNSKYEFIFNHVNPGIHDLSLVSHDFILDKDRFRIEANHSTITATDYYLNGNKGQASNVTDTVLVVSVVGERKYYEVRSGSVKEMLLNSPLGFIFKNTGYTIMFVATLVMMAGPYVLSIVNPEMSKRLAEIREEQGQGRGMFDPKPEAPKIEEISRSAPARGTKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXJ3</accession>
    <name>G3AXJ3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_112127</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXJ3"/>
    <dbReference type="STRING" id="590646.G3AXJ3"/>
    <dbReference type="eggNOG" id="KOG0727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="193"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="416" mass="46548" checksum="6CEDEF17CDE02AAA" modified="2011-11-16" version="1">MEELGIIDSSSVQAQFSPVGKLNPKLSNYDDNSDVYLKLKKLEKELDLLKLQEDYIKDEQRHLKRELIRAQEEVKRIKSVPLVIGQFLEPIDENTGIVSSTTGSNYVVRILSTLDRELLKPSSSVALHRHSNALVDILPPEADSSISIVSDDKKPDVTYADVGGLDMQKQEIREAVELPLTQGDLYTQIGIDPPRGVLLYGPPGTGKTMLVKAVANSSTASFIRINGSEFVQKYLGEGPRMVRDVFRLARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSTVKVIMATNRADTLDPALLRPGRLDRKIEFPNLKDRRERRLIFSTIASKMALAPEADLDSLIIRNDPLSGSVIAAIMQEAGLRAVRKNRYMILQSDLEEAYTAQVKTGSEQDKFDFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXT0</accession>
    <name>G3AXT0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_118208</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXT0"/>
    <dbReference type="STRING" id="590646.G3AXT0"/>
    <dbReference type="GeneID" id="18248626"/>
    <dbReference type="KEGG" id="cten:18248626"/>
    <dbReference type="eggNOG" id="ENOG502QTKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027285_1_0_1"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000111">
        <property type="entry name" value="Soluble cell wall protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442684" description="Glycoside hydrolase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="37798" checksum="71FCF1EF3E26B502" modified="2011-11-16" version="1">MLFKSIVTGALAATILAQPLQDEHQHQHQHEKRAVKVVTQVNTVVVTAGYGAADIPTTSIALSAATDVSINTDTTITPQNQPASFSNPTTFETKTSTSAVSTASASEAIGASGAKGITYSPYSDDGGCKSASEVASDVAQLSGYDIIRIYGVDCNQAANVLAAIGDNQKIFAGIYDVSDISGGVSTLAAAVEANGGWDKVDTVSIGNELVNGGSATVSQVGSYVAEAKSALTAAGYSGSIVAVDTFIAVINNPGLCDHSDYMAVNAHAFFDGYYTADQAGDWLLQQIQRVYTACGGSKRVFITETGWPSQGDSNGKAVPSAENQKAAIQSIIDTCGSASTLFNAFNDIWKAPGAYNAEQYWGILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYL5</accession>
    <name>G3AYL5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_129324</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYL5"/>
    <dbReference type="STRING" id="590646.G3AYL5"/>
    <dbReference type="GeneID" id="18249377"/>
    <dbReference type="KEGG" id="cten:18249377"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_1_1_1"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="160" mass="16333" checksum="647F3E236F73A13C" modified="2011-11-16" version="1">MSDLCPVYAPFFGSIGCAAAIVFTCFGASYGTAKSGVGICATCVLRPDLLVRNIVPVIMAGIIAIYGLVVSVLVSDSLSQKQALYTGFIQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALLLNSRANQDVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYX4</accession>
    <name>G3AYX4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inorganic phosphate transport PHO88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112831</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYX4"/>
    <dbReference type="STRING" id="590646.G3AYX4"/>
    <dbReference type="GeneID" id="18246695"/>
    <dbReference type="KEGG" id="cten:18246695"/>
    <dbReference type="eggNOG" id="KOG4554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099163_0_0_1"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="195" mass="21294" checksum="9F6E679B57FD6DDF" modified="2011-11-16" version="1">MFGMSPAVSNIVIMLAMMQVSRRLDLENPDILFYVRVIYITLQALTLGVYLFTKMKINAKNDLTTLKYVEPANPMSGQGETPVITTVKEYDLKQVDTQIKSVFQSLAMMGFMHLYMKYTNPLVMQSISGLKGALEANIVKIHLFGTPATGDLKRPFKSAPGLLQALSGATAGDVKTDKHSVESAEISGAGGIKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYY8</accession>
    <name>G3AYY8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_133394</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684539.1">
        <property type="nucleotide sequence ID" value="XM_006684476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYY8"/>
    <dbReference type="STRING" id="590646.G3AYY8"/>
    <dbReference type="GeneID" id="18249700"/>
    <dbReference type="KEGG" id="cten:18249700"/>
    <dbReference type="eggNOG" id="KOG1573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050259_0_0_1"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV65965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="328" mass="38756" checksum="2C7591FA54DA57A7" modified="2011-11-16" version="1">MTDLKVTKPSSKNGRLLDKIDDNVLLVNQLKAELKSKLQEKQGIPSETCDTENEPEDDWKQDTEQYKDIDPKSFRQYELACDRVKEFYEEQHEKQTVAYNIQARINFKTRVRAKMTIWEGLEKLNKLLDESDPDTELSQIDHALQTAEAIRRDGKPRWFQLVGLIHDLGKLLYFFDSKGQWDVVGDTFPVGCKYSKKIIYPDSFRKNPDMNNPLYNNKFGIYSKGCGLDKVMLSWGHDEYMYHIAKLNSKLPKEGLAMIRYHSFYPWHQENAYKYLMDDHDKEMLEAVRAFNKYDLYSKIDDAFDVEQLKPYYIELIDEFFPTKVIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ48</accession>
    <name>G3AZ48_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein RAD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_119056</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ48"/>
    <dbReference type="STRING" id="590646.G3AZ48"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="488"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="840"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="922"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV66007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1096" mass="125804" checksum="E105AA4072652698" modified="2011-11-16" version="1">MANTKSSYFDKLRAKRESQATKELPVSSELPQEALPVKEEPLFVEDSEDEFEDAISVQRSEDFTKFKDALTNVLGPLGDHIIEPLYQKFSGYDDKVLLAIDYHLRGDVKMKVPKSIPPITLSMDVKRKRTRGIQMPLTYNKRASPARPTESESKPTVTEWKRFLGTLFADAYATRPYLKSLSYLQKMSIRSLKPRVLTGKQKKRTSDTAVIRLYTSTPGDVSDGREIGRLKEDLTRILAPLLDLCIFEFEVTVALETTKRLMIGDEFYVKIDCFLTSGAFEKTKSPINELDTMKETRTNITNETEEESNLRLRKFAVAALFSRLQIRPVKAKDSLGATQVNSSDENPHQIIDLDSDEDDLENNELSLDELQTFYSENQQSEMLKALPNTTTPPAENFSLQLREYQKLGLSWMLAREKELDVLKSLNSSGSDLEESFTSQSIDELQLMEDGVMNPLWKTFRWPKLESKDVHSDVFYGNMYSGELSLQKPLIKSSLRGGILADEMGLGKTISTLALINSVPYDTRSSFHGDQYASQTTLIIVPMSLLAQWENEFDKANNNLNHKCIVYYGSSTPNLQSVLLNKTKHIPIVVITTYGTVASEFARLQNRGDLFDFPGMGLYSVKFFRIILDEGHQIRNRTNESSKAIFQLQSSRKWILTGTPIINGLDDLYSLAKFLELEPWSNLSYWKMFVSLPFKQKQAKQTLDVIKTILEPIFLRRTKSMKGDDGNPLVDLPPKEVVIEEVEFNNDENQVYSWFKDLAYKQFRDKLNSGESLRKHLWTHILRLRQICCHQDLIKSLITDMKEQNLLPEDTVEHDIFKDHTEMMEAKYKLYDKIDINNSECSICTKTPIDMSEISITTCGHTFCLNCVIEHLEFQKKKNQNRSCPNCRGPISTYKIFKVRDKKDFDFDIYLYDPSKVSSKVQALINHIVTLKDQNLTEPVIVISQFSSYLEIIETELLLRVGEKNIRCLKFVGSLSKIQRQEILEQFNNSAHYGNQITVLLLSLKAGGVGLNLTNASRAFMMDPWWSPSIEEQAIDRLHRIGQQKTVKVIRFIMKNSIELKILKIQQRKKQLGEVVAADEDEQRRVSDEEIRMLFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ65</accession>
    <name>G3AZ65_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112880</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684856.1">
        <property type="nucleotide sequence ID" value="XM_006684793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ65"/>
    <dbReference type="GeneID" id="18246719"/>
    <dbReference type="KEGG" id="cten:18246719"/>
    <dbReference type="eggNOG" id="ENOG502RYG1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037332_0_0_1"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="58951" checksum="1B7560FC3732CA26" modified="2011-11-16" version="1">MGLGFNTVSSVLILVSFVFLLLATISTPIVSSFSLASTSSFTYGVFGYCSDKSSDCTASSADYPYSLGSVQPRLDWLLDRDTRNHLASTLIIAPIACGFNFVCLIVVFVSHFFSSGILIFSIVFNILTFLLTALIAILVVLMFHPYVSWTGWILVGSAAATLISIVFLFLELRLSNSPVQSDVESINEMATFDNKFGAGPPVGAFMPPNSTAFNRGYSNLDNDSSISKDYEFKATGNQVNNQVSKTMTNSSIYNSNPQMAKDFTQYSNNSFGSRTAGSSHFEDAQVNFVNGPNTPISSKQQMAPTFVPNTATPTTNDTPESRVPHLPYPAGRPLNKPPYGGADMSVFEHHPEVEGHEPFTELNDDLPPQVEPANQYVHRGSQTSDLSDASSDFTSVSQRAINPRYNPQQQYGGPEYLPPQQQYQTSYPQQQPFQPQFQQQNPGYGGSPMMNQNIPPVTSHQQPMMNYGPPPPNQHRFMMARPQPTASDNALANNPDFAIGGVRKKPGMNKPNMGASRMGIPGMGGSKPGQGGAGTGRGPYGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZF6</accession>
    <name>G3AZF6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112945</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZF6"/>
    <dbReference type="STRING" id="590646.G3AZF6"/>
    <dbReference type="GeneID" id="18246748"/>
    <dbReference type="KEGG" id="cten:18246748"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="40"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="510" mass="54771" checksum="E32CB4ECC4E17FA9" modified="2011-11-16" version="1">MGIPKAWVITKRHLTDSVQVIGSLKNPNLFQTQGYINGRYVDSSSTQTFDVNNPASFPDPKSYIGTVQSMTADDFNTAVGHAETAFKTFRKTTAEYRSDLLRSLYNSYIKNQDDLAKLIVLENGKPYADALGEVKYAASFFKWYADIATTKTGDIINSTGTNKRILSLKQPIGVCGIMTPWNFPAAMITRKLAAYVAAGCTGVIKPASETPFSALAMGHLQEQAGFPKGVINILPSSNAAEVGKLLCEHPGIKKVSFTGSTNVGKLLMSQSASTLKKLSFELGGNAPLIVFNDVDIDSAVDGAIASKFRSSGQTCICANRIFVHESIYDEFSEKFASKLEASVTLGDGLDQGVTHGPVIHERSFAKVRSHIEDAVSKGAKIISGGNPRPDLGVNFHELTILAGVTSDMLITQEETFGPVCPLIKFSSEEEVLAMANDTDVGLAGYFFTNDIRRAFRVAEELEVGMIGVNTGAISEAALPFGGIKASGFGREGSIYGVDDYMVVKSMVIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZJ8</accession>
    <name>G3AZJ8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1680-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_91918</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZJ8"/>
    <dbReference type="eggNOG" id="ENOG502QYM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013148_1_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049049">
        <property type="entry name" value="Beta-AFase-like_GH127_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20737">
        <property type="entry name" value="Glyco_hydro127C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="1">
        <location>
            <begin position="33"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 C-terminal" evidence="2">
        <location>
            <begin position="538"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="637" mass="72926" checksum="16D4F713C35FCC48" modified="2011-11-16" version="1">MFSGVKNILGLGSTAPNIVYGKTDKDLGVERFVEDDFWKLRIRTVAANTLPSMHNVLMKTGRWEFFDFNWKHLKDIEPHIFWDSDIAKFLEAVCYALKYTEKDEQIYQTYVDWIDQIVRMAKKAQQPDGYLNSYFTQMDPKARFTNIMEKHELYCCGHLIEAAVAHHEATGSMELVDIMCKYVDLLYLTFGPGEGQLHGYPGHEEIELALVKLLRIVPKKEYFDLLNYFVEERGQNNTEFYNDELRRRNIDPDVYNPLADYDHMDSDYTHMLPAPKSYWYSQSEKPIRELEEVRGHSVRLVYYLTGVQGLAMLKKDDSLKKAVRRLFDNMIDKKFYIHGGIGAIDRWEGFGEDYDLRWDGYSETCASIGLVFLCERMLSDKLDKKVALAMERALYNDVLGGVSVTGKSYYYNQPVCGCGLTRQSWFVCACCPPNVARLFSSLEKYAVSVSDDSIAAHLYIGVSLKSDDLDFKLVSKYPNEGKIELKIDSKKPITISIREPNTAFRTSNSKYKLSNGYLTFGPRIWTSETITIEFDIPVEIVKPDPNVTANSGHLAVQRGPYAYALQKSGVSGDVSLDDIKISVNQKFEVSAEEYENAKYVSLTTTADGRTLNFVPYFITGNEHPGEDFRLWIKDGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B085</accession>
    <name>G3B085_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_113060</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B085"/>
    <dbReference type="STRING" id="590646.G3B085"/>
    <dbReference type="GeneID" id="18246808"/>
    <dbReference type="KEGG" id="cten:18246808"/>
    <dbReference type="eggNOG" id="KOG3158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078883_0_0_1"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="248" mass="26050" checksum="C60F8CE44BB52E18" modified="2011-11-16" version="1">MSALTPTVRWAQRSNASDETKNIVFLTIEVFDVKNVQVDLTSTTLTFSADSQNSDNKYEWKVEFFDEIDTENSKKNLGAGSHVSLLLRKAKKQEEYWPRLTKEKVKYRNIKTDFDKWVEEDEQDEKEEEPDLGMGGMPGAGGMGGAGGAGGMPDLASMMQGMGGGAGGAGGMPDLASMMQGMGGGAGGAGGMPDLASMMQGMGGGAGGDFDISKLASQLGGAGGIPDLGEEGEEGEEGEQVEEIAEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0F3</accession>
    <name>G3B0F3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_119727</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0F3"/>
    <dbReference type="STRING" id="590646.G3B0F3"/>
    <dbReference type="GeneID" id="18248724"/>
    <dbReference type="KEGG" id="cten:18248724"/>
    <dbReference type="eggNOG" id="KOG2267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026253_1_0_1"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="318"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="502" mass="58272" checksum="E28C34362BD50387" modified="2011-11-16" version="1">MFRQAKRRTAGRRNFDTKNVIYQSSKLAALYTSRLSFYDIPPLEEITLEEFESWAIDRLKVLIEIESCTARSKSFKEIEQIIKPVVNKYLPLSPLIEGKNDAQVLQERKKDHYSHYILRLVFCRTDELRKKFVKNEMLLFKIRYGNMQLSEKSQFIELHNDTLDWNYIGAEEKTELFEDLFNATSASIRTQMMLDNEKSTITGEQLRQHILRNESFIKLPFEKIPNLVGSRSILVRQGYGYIPTSFQLNLLVIEVQENLSKNLVKTFQAIPRLDEDDRLVPLLQALSKNFSSVQYDSNFGDESASDINATSITSNKIMSHYPLCAKVLQKSLVANHHLRFQGRQQLSLFLKGIGLNVDEALRFWSTQFTSGNTGISLEKFNKEYKYNIRHSYGLEGARINYKPWDCATILSKPKPNKSESHGCPYRDLKLEVLVDNLKDMGITEQSDLNVIIDDVNKNSYTVACTRVFELTHKKQLKPNENLHINHPNLYFDRSRQLEKAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0H3</accession>
    <name>G3B0H3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_113142</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0H3"/>
    <dbReference type="GeneID" id="18246833"/>
    <dbReference type="KEGG" id="cten:18246833"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="61"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="385" mass="40527" checksum="D701CAE8B0F6F7B7" modified="2011-11-16" version="1">MSLAWVASAATIPSGFQKRGDGYIKLGFDIQSAGHKNISPPGLSKRSGTDNLPLFQDSYFYKADIQVGSRNDAISVEIDTGSSDLWIIDTSAGVSTSAGTYDSSKSSTYQYVNNQFEIGYVDGSSATGNLVKDTVTLGSGSGGPVLKNQEFGDVTSTSLGQGIFGIGFPSLEAGHQNSNAAIYTNIPANLKAQGYIQKNAYSLYLDGVGDSSGTVLFGGIDHDKYSGDLVTLPVTNSDRLNVDVDSFGVGNSNISDGTSYTLDSGSTNTWLPASALKSLADAAGAIYDSNIGAYVFSDCNSIPEVSVNFNGISITIPSTDVSKTLYSNNGNVLAQCGLLFFENNNYPTLGDNFLRHAYVVYDLDDREISLAQVVSSASENITPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0K1</accession>
    <name>G3B0K1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92640</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685238.1">
        <property type="nucleotide sequence ID" value="XM_006685175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0K1"/>
    <dbReference type="GeneID" id="18250217"/>
    <dbReference type="KEGG" id="cten:18250217"/>
    <dbReference type="eggNOG" id="ENOG502RPY6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582650_0_0_1"/>
    <dbReference type="OrthoDB" id="4018768at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="580" mass="64721" checksum="3CBFBFA62AD9CAD2" modified="2011-11-16" version="1">MTVQVLGAAPVTSSRLDHLLILVDNIGAKSDLLIHSFHQSDAFASQICHYSTSISDMDVRIDDSHQVLKDNYQHMTEFHELSSRLYLFEHDLNHNDSTTNSHIYSHLCLEFDYLREKYATTATTSWSSSRDSPNSIHNPKNPPDGGNIQSTPQEAALSNSVSISNMNLKPIRCKPNKVYKKKSHYKISNLFNGPILNSPEELHSGLHSLHHDSTADSIHHGVNSSSDTLDNLMDVTFPQSNDTTPELELHDFDMDKPEDINVNPFDSKGSVFLSTIDCDFNDNESTLSDAPEMDFENFDSFLRRSRVNLSQDSYPYVVRKSVSDASINMTSVDPNIPSVHAMDGNADVSNDSPSKKKVSSFKFHNPIDNIKQSHECLSPTVEAIYSIPSSKSHDGERSNYESLLNKFITPETTPKKDSDSSFSLFNFINSPSATRKHSNSEQPQNQRNSIIGSSLSETFLQLMQTESSVQLVGKKTNTPILVQQKLGDGNSCGSNSRRRKREKLEELKSAPKTKPITIQNETNLKRYPPAFTSNSSSSSLVLNSNKSFIVNHGNMSIFKKPVVSSFSHRSLQEALTSNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0R8</accession>
    <name>G3B0R8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_102712</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685146.1">
        <property type="nucleotide sequence ID" value="XM_006685083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0R8"/>
    <dbReference type="GeneID" id="18245576"/>
    <dbReference type="KEGG" id="cten:18245576"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59344" checksum="59BAD3C983202314" modified="2011-11-16" version="1">MADDSNKSLEKEALNISEDYSSVSVNLINIEKADATLIFLDAHEQEFAGVELSDEEHSVITNKVHWYLLPLLIAVNTLLFMDKATLSYAAILGIYESTNLTDSLYDDLNSIFYTGYTVGQLLNFVLQKYNLRIFLTIIVFLWSVVVFLHAAAFNFGGLVVLRLVLGILESIVVPALEVSLFQFYTPTQRATIQPVFWIGCVGFPVVIVGFMAYGVLYAKDTIPPWKIFMIINGGITLVMSVIIYIFYPSDPSQANFLTDKEKFFLIKRVQKESKASITQHNIKRHQIIECLRDPITWLFALFSFLIMLANNLNYQQNLLYVSLGVSNLGSTLVSVAGGGFASAFAVFGAILTHYFPNNSFWICVVGCLPSIAGGIAMVTISWSNKLALLAMLVLAANTYFLAYIVGFGWSSSSCSGNTKRYFRHFIFCVAYGIANIISPQLWKGNQTNRYYAAWSVQIVLAWFGTPLVAGVITLILKARNKERLAYIESHPEALFGTVVKIDPETGKEVTEKVDIGSLDLTDLENKTFIYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0V3</accession>
    <name>G3B0V3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113583</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0V3"/>
    <dbReference type="HOGENOM" id="CLU_1786594_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="145" mass="15807" checksum="7A94238BEE070732" modified="2011-11-16" version="1">MASDSSRDTAIASASTPATSHNDKFDITGIPVSPKPLEIDSDYLDSNLNSLAHSPTYSIFSNESEVKLDLNLIQSNELNDKMLVDYLDLGISGARKAQFEMPESGSLAGIKKIKLEPSDGFELSASRQNNEIGDYSIFDEVINFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B106</accession>
    <name>G3B106_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_130022</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B106"/>
    <dbReference type="STRING" id="590646.G3B106"/>
    <dbReference type="eggNOG" id="KOG1687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_1_3_1"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="4">
        <location>
            <begin position="83"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="208" mass="23109" checksum="8A40BB57EFC202A6" modified="2011-11-16" version="1">MFSSINRRAVGLARRPNMALIAAGASRTISSKDLTPKTMPTDFPLMSQKAASAPVDYALTSLDTIANWARKSSFWPVTFGLACCAVEMMHVSTPRYDQDRLGIIFRASPRQSDIMIVAGTVTNKMAPALRQVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIIPVDVYVPGCPPTAEALMYGVFQLQKKMMKTSITRLWYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B116</accession>
    <name>G3B116_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113623</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685957.1">
        <property type="nucleotide sequence ID" value="XM_006685894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B116"/>
    <dbReference type="STRING" id="590646.G3B116"/>
    <dbReference type="GeneID" id="18247049"/>
    <dbReference type="KEGG" id="cten:18247049"/>
    <dbReference type="eggNOG" id="KOG2382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_53_0_1"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="66"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="321" mass="36054" checksum="143566A61647D309" modified="2011-11-16" version="1">MRFQANVIASRTITRGFGRFLHYDGTPSSYASNSADYLGDALDPNIETVDLAYDLYEAETKTSNSPLIILHGIFGSGVNHRTAGKILASKLKRDVYSPDLRNFGRSPHIKRLDYPSLAADVERFIENKNLEKPVVIGHSMGGKTAMALALRRPDLLKMLISVDNAPVAFSSTSSTFVKYIGAFKRATENYKFTNIKDVDKELAKVEPNQYIRQFLLTNMNRGKKDDVITSKVPLDIINDALHAGLIASWPYDPSVCRWTKGPALFIRGTESDYVPDEYIPDIGRFFPNFEIRDVKAGHWVISENPKDFVDTVVDFVVKHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1N5</accession>
    <name>G3B1N5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_113256</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1N5"/>
    <dbReference type="STRING" id="590646.G3B1N5"/>
    <dbReference type="GeneID" id="18246870"/>
    <dbReference type="KEGG" id="cten:18246870"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="336" mass="36458" checksum="43E15DCA53278584" modified="2011-11-16" version="1">MTTSVFVSGATGFIAQHVVQQLIQKGYKVVGTVRSTEKGDRLKANLKSDNFEYEIVKDIAEEHAFDEALKKHPEVTVFLHTASPFHFNVTDVQKDLLDPAVKGTTNALSSIKKYGPQIKKVVVTSSYAAVAPPIGVLGPEFTVDETSWNPTTLEEALSSPGLGYRGSKTFAERAAWAFLDTEKPTFTLNTVNPSFVFGPQVFDSEVSATLNTSSEVLNSFTRLSPTDDVPVVKGGYVDVRDVARAHLHAFESDVTGFRYLLSTGPFVGQDIIDVIRDNIPQLKDQVPKGVPGSGAEEIKKLNGVDNSKTAAKIGPFIDLKKTVVDSIEQILAVNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1N9</accession>
    <name>G3B1N9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_103596</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1N9"/>
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    <dbReference type="GeneID" id="18245640"/>
    <dbReference type="KEGG" id="cten:18245640"/>
    <dbReference type="eggNOG" id="KOG0434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_1"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="20"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="696"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1082" mass="124744" checksum="518AE38CAC2232B1" modified="2011-11-16" version="1">MAEKETANQFFNFPQEEENVLDSWDDMDVFQRQLELTEGLPPFSFYDGPPFATGVPHYGHLLTSTVKDIIPRYASMNGHYVERRFGWDTHGLPVEHEIDKKLGINCKEDVMKLGIANYNKECRSIVMRYADEWRRVIRRIGRWIDMDNDYKTLYPTFMESVWWVFKQLFEKDSVYRGLRVMPYSTGLTTPLSNFEAQQNYKDVNDPAVTVAFQIKGQEDTYLVAWTTTPWTLPSNIALCVNPNFEYVKIFDEEKQKYYILLESLLKSMYKKPAAAKYKVVEKISGKDLDGIKYVPLYDYFVKEFAEHGFRVYCADFVTDDSGTGIVHQAPAFGEIDFEAAMKAGVISEKRTPPNPVDDQGKFTKQVPDFAGLYVKDADKVIIKDLTEKGNMLLSTQIKHSYPFCWRSDTPLLYRTVPAWFVRVGEIIPDMLKNVDETHWVPNNIKEKRFSNWIANARDWNVSRNRYWGTPIPLWVSDDFEEIVCIGSIDELKELSGRDDITDIHRESIDDIVIPSKKGKGNLKRIEEVFDCWFESGSMPYASKHYPMEGKDSFHDVFPGNFIAEGLDQTRGWFYTLTVLGTHLFNTAPYQNVIVTGIVLAADGKKMSKRLKNYPDTKVILDKYGADALRLYLINSPVLRAETLKFKEEGVREIVSGVLLPWYNSYKFFKDSADIFKKENGVDFVYDPSSISTNVMDKWLLASIQSLIKFIHEEMSSYRLFTVVPRLLRLIDDLTNWYIRFNRRRIKGYSNEGIKDTQMGLNTLVEGLLILSRTMAPFTPFLAENIYLKLKPYFTEDYLNSLVVNPKHKDIRSVHFLSFPTVREELFNKEIEVAVGRMQKVIDLGRNIREKKTISLKTPLKELVILHADPEYLKDIESLQGYILEELNVRNLVITSDEAKYGVVYTVVADWPVLGKKLKKDAKRVKAALPSVTSEEVQEFAESGKITVDGIDLVKEDLQVLRGLPDTAAGQGHEVRSFQDLLIILDVKLYPELQGEGLARELINRIQRLRKKAGLNTTDEVQVEYKLVKDTIDFKTILDTQSDILLKSTKLPIQEFSDDKDKVIIDEEQSINETVFNLRLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2C7</accession>
    <name>G3B2C7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 21">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 21">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTEDRAFT_129867</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10573</strain>
            <strain evidence="24">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 21">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 21">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 20">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 21"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2C7"/>
    <dbReference type="STRING" id="590646.G3B2C7"/>
    <dbReference type="GeneID" id="18249407"/>
    <dbReference type="KEGG" id="cten:18249407"/>
    <dbReference type="eggNOG" id="KOG2550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_1"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 21" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 21" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="120"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="183"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15 16">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15 16">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="279"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="329"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="369"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="392"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="416"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056556"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV65207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="524" mass="56381" checksum="E9EB43D94E4B89AC" modified="2011-11-16" version="1">MTVLDASKATEYLKDYKSKDGLDIKSLIDSANFGGLTYNDFLILPRLIDFPASNVNLETKLTKKISLKSPLLSAPMDTVTEEQMAIHMSLLGGIGILHHNCTADDQAEMVKKVKKYENGFINDPVVIAPEVTVGEVKKLKEVLGFTTFPVTENGQVGGKLVGIITSRDVQFHDDDKSTVKEVMTKAADLITGKKGIKLDEGNALLRKSKKGKLPIVDEEGNFVSLISLTDLQKNQSYPLASKSYHSKQLLCGASIGTLQADRERLAKLVDAGVDVVVIDSSNGSSLFQIEMLKYIKETYPELQVVAGNVVTREQAALLIEAGADALKIGMGSGSICITQEVMACGRPQGTAVYAVSEFANKFGIPTIADGGIGNIGHISKALALGASCVMMGGLLAGTSETPGEYFYRDGKRLKSYRGMGSIAAMQQTSSNANASTSRYFSEADKVLVAQGVSGSVVDKGSISKFIPYLYNGLQHSLQDIGIQSIGELREKVYEGEVRFEFRTASAQLEGGVHGLHSYEKTLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2F8</accession>
    <name>G3B2F8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113453</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2F8"/>
    <dbReference type="STRING" id="590646.G3B2F8"/>
    <dbReference type="eggNOG" id="ENOG502RXU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="259" mass="29244" checksum="D1AE4C0317CED273" modified="2011-11-16" version="1">MFTRFIRHIHPLGPRYGAHMLHTTSPTAYALFKDLPRKESRPLSQLTAEVQPPQEQSQTDTTTTISFHDGPIVADPVAPAPGQPINWSDSFHGLGVAPFPREVSDVLLAPLNEEDIEIKPDGLLYLPEIKYRRILNRAFGPGGWGLAPRTESFITPKQISREYALVCHGRLVSVARGEQDYFGGEEKVATALEGCKSNALMRCCKDLGIASELWDPTFIKSWKKKYCDEVFGEHVVNKKKKKLWKLKRNKALDYPYKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2T5</accession>
    <name>G3B2T5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_92994</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2T5"/>
    <dbReference type="STRING" id="590646.G3B2T5"/>
    <dbReference type="GeneID" id="18250244"/>
    <dbReference type="KEGG" id="cten:18250244"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056878_0_0_1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071248">
        <property type="term" value="P:cellular response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="301" mass="34010" checksum="0C61922B60EE6CD2" modified="2011-11-16" version="1">MSVYNNNNQDVKPILPALNGQPQSVPQDINLPYQMPIQSKSPGNYPMGSYSMQNASYVNTYSQPQQQPLPPLHFYSTKNYVVDNTTGSNPPINTQSHPHVHHQPYPVLHYPSVSPVQTSSMPQYNYYSGPVKAQSSDSEHEGSGTGTDKFAIDYSSIINYTNSPSLKRKRRQHTYEQEGSTLPKLPCSVCGKVFNKPYNLKSHMRSHSTDKPYGCTVCGKKFARSHDKKRHELLHKGEKSFKCDGFLKDGKTRWGCGKKFARSDALSRHFRTETGWLCIKPLMDEAKHLESKDLINNLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2T6</accession>
    <name>G3B2T6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113534</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685564.1">
        <property type="nucleotide sequence ID" value="XM_006685501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2T6"/>
    <dbReference type="STRING" id="590646.G3B2T6"/>
    <dbReference type="GeneID" id="18247007"/>
    <dbReference type="KEGG" id="cten:18247007"/>
    <dbReference type="eggNOG" id="ENOG502S4PT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078856_0_0_1"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="175" mass="19766" checksum="7527ACBDCD974445" modified="2011-11-16" version="1">MLPESATKLLKSTRFLHLATSYQDVPHVSLMNYTFYQDNGDDYVIITTPANTTKYHNIKHNHRVSMLVHDWISAKPDDGNSSSGTSTGRRNSLYDLITNLNKTQLSSVSVMVDGEAEIVPESDGRHKFYHSLHMNNQNIDTQQLDNYVKADTTELIVVKVTGCKITDTDNNVVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2V4</accession>
    <name>G3B2V4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PIG-U-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113548</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685574.1">
        <property type="nucleotide sequence ID" value="XM_006685511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2V4"/>
    <dbReference type="STRING" id="590646.G3B2V4"/>
    <dbReference type="GeneID" id="18247014"/>
    <dbReference type="KEGG" id="cten:18247014"/>
    <dbReference type="eggNOG" id="KOG2552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030193_0_1_1"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442744" evidence="10">
        <location>
            <begin position="20"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="435" mass="49411" checksum="A21C3A1582E88078" modified="2011-11-16" version="1">MNQTHRILCIGVLVRFLLPTLFPSIPFKLSTVVELATPINSYTSLQEAFFYLQHSINPYDGGVNHHPPLLVAFFGLFKSQLPDSVFLTACNLLYSVVDVIIALRLASLNRWYNARVSKKTGEPVAPLSDALMVSFYLFNPLIILTNLSHCTLVFSQLFIIESLHQLTSNTNLARAMVSLGIATYLSGSPVLMVVPVLALAYVSLPKHKWENVYIQGTVVFFMTCGLLVFISAIWTSSVAFLDQCYGVIIRFDKIQPNVGLWWYFFTEMFDFFTPFYIGVFNLFSMIFIVPLTIRFFEYEDKDPKKASVKTGDAFLAVYLCYVWMSFLKSYPTVGDFGLAISLAPIFAATVLPYCKLVYITALTLLVCLILSPIFYYCWIVLGNGNSNFFYSINLVWGGVHILVLIDFTWGQLIREYCQEHDISPEQRHVIRLTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B321</accession>
    <name>G3B321_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114094</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B321"/>
    <dbReference type="HOGENOM" id="CLU_2120798_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="114" mass="12441" checksum="A7530182C21A2311" modified="2011-11-16" version="1">MRIGRSWDPGSRPSPAIGNMPKSVSNNNGIDGNDNGSVSQGIFVNLSAGKSYWVRCWPGVYQLSLELVGSSAFDQPVRDKCSLAAILRRTGEFVINSYRINVIYNTCLQREAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B365</accession>
    <name>G3B365_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114132</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B365"/>
    <dbReference type="STRING" id="590646.G3B365"/>
    <dbReference type="GeneID" id="18247275"/>
    <dbReference type="KEGG" id="cten:18247275"/>
    <dbReference type="eggNOG" id="KOG2396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026025_3_0_1"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="415" mass="48690" checksum="8334E4A75956961E" modified="2011-11-16" version="1">MAEKVRYYLEQAVPELEDLQKKGLFEKHEITMIMRRRTDFEHRIQGRGSTTRDFIKYSEFERNLEKLRKKRYTRLGKAGLVDTKPSISDWAGVRRILFVYQRGTYKYPKNLELWAQYLDFAKKNGAIKVVYKIYSRLLQLQPRNVDAWLSSAKYEFEINNNAKGSRVLFQRALRLNPESSELWLNYFQFELTYVSKLLTRRKVLGLLTEGQQREQMEKEVKEYHDKLNQDNALNGDGQDDNEIALPTEELRDELNTLPEADMNMLGNPETNPALKGDVALAIFDASLPELIKPKLFKRVEKLFVLINRFLDIIDKFDDLNQDYLYLHVLSMLQSEYPHELNTALIDITLPIRTVSRNEPDFAANLQLSVNKFMAYKLKTEGLEKSELVKAYVNYLEKFVEGDDGLMRAIIKKCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B387</accession>
    <name>G3B387_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114140</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686684.1">
        <property type="nucleotide sequence ID" value="XM_006686621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B387"/>
    <dbReference type="GeneID" id="18247283"/>
    <dbReference type="KEGG" id="cten:18247283"/>
    <dbReference type="eggNOG" id="ENOG502RQ79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122011_0_0_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="153" mass="16813" checksum="D2D66A96120E33CA" modified="2011-11-16" version="1">MSDNYSHPPEDPPSYTESTHQQQSVTGPSSPPLSDNITIPQKAPQYEGNNEYPPEKQQPPPNGKYDPMADPKVYKVPPQLVNITQANPQHLNPSYPQYQEREQQRLAQGHAPNPARWKHGAPLEPGKTNPSHKTGGSSFPGRGGATYNNAANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3E2</accession>
    <name>G3B3E2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114175</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3E2"/>
    <dbReference type="HOGENOM" id="CLU_2229433_0_0_1"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="106" mass="11739" checksum="67A1CD96E3B5BBA3" modified="2011-11-16" version="1" fragment="single">MQHSDMRTTGGGTQCASKQQSRLTKTEEGVPDKQVGGGRQPHKCKPRQEGPTTCHRAQSLSHALHLRWLTCTPAYGRKLMNFNSCITNSNSRSLKPLDAKAYQCPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3J8</accession>
    <name>G3B3J8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114236</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3J8"/>
    <dbReference type="STRING" id="590646.G3B3J8"/>
    <dbReference type="GeneID" id="18247326"/>
    <dbReference type="KEGG" id="cten:18247326"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="104"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="462" mass="50726" checksum="A93DD4F8FFAA2CF5" modified="2011-11-16" version="1">MAPSASKTAAKTKPADLTVPPSPLDAGNRSLKHYQSGLSPFRFRLRNRILPVVRKETQILANIQAKVRTPTLDFYFAWSANLASHTFYVLMLPLANWFGSEKLARDLVFVLGFGIYITGNLKDFLCLPRPRSPPLHRITLSSYTAQEYGFPSSHSANATAVSLIMAVKISELSCSTVAKIMLYAAIAVYYVSLIFGRVYCGMHGFFDVLTGTAVGTVLFLFRHWYGQWWDSVVVLDTAGRWGWFLPPVLVAAYLILVHIHFEPVDNCPCFDDSVAFIGVLIGLDLSHWLAYKTGYFATAGTVGSPLIVPFDFEHLGLVKTILRVAVGMTLVVSWKAVSKPVVFTVLPPIYKAIGVNLPRKNFEATAFSAQTNRQIRKASISNLDAEEAKFIGQAKDAVGVQDDIDYYEMIGSGGSEAPPDRSAGVFKSRYDVEIIGRLIIYAGVATASVWGFAVVNSTLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3R8</accession>
    <name>G3B3R8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_113739</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573</strain>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3R8"/>
    <dbReference type="STRING" id="590646.G3B3R8"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="30"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="441" mass="49794" checksum="13F1BAA99584E01D" modified="2011-11-16" version="1">MENFDKGSHLKKLINKINGQPESYGRKAQYIFGKTLGAGSFGIVRYARNLDTGEEVAVKIILKKALKGHEDTVLAELDLLSELSHPHVVGFRDWFESKDKFYIVTQLATGGEMFDRIIKKGRFTEHDASLVIVQVLEALQYLHHKNIVHRDLKPENILYLTPEDNSNIVLADFGIAKKLQSADDKIHSSAGSFGYAAPEVVMGLGHGKPCDIWSLGVITYTVLCGYSPFRSENVHDFVEEVKNNNGVVFHADYWKSVSKDARRFIIKALQFNPDNRPTVDQLLNDPWLIDVAKEHKEMDLLPQIKAKFDGKSKFKQAIELVMLNNRVSKLKDIQTEDDDDPNEINIFGDEGSLVSEEAIKDAQKNTAHPLISWGKFKQALPDAEMSKSSLSKPMTEDSKLNSPERKKDLTQGAFVQLVHVASKNKDRVSQFTDENRKRDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B405</accession>
    <name>G3B405_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose 1-dehydrogenase II (GLCDH-II)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113935</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B405"/>
    <dbReference type="STRING" id="590646.G3B405"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="247" mass="26355" checksum="2524DB559090D5FD" modified="2011-11-16" version="1">MALLQDKVAIITGGVTGIGRSIALGMAREGAKICVNHLPTDKQAELAEEMAQEVGPENFLAVPGDISKQETSTNLVAEAVKKFGEVNILVSNAGICEFNDFLETKPETYLQTIEINLNGCFFVTQAVGRQMKKQGKGGSIIGISSHQAHYTPTKAGILSLMQSCACALGQYGIRCNALLPGTIRTAVNEEDLADDEKRTYMENRTTLGRLGKPDDLAGPAIFLASDLSAYMTGSQLLVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B418</accession>
    <name>G3B418_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_105149</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B418"/>
    <dbReference type="STRING" id="590646.G3B418"/>
    <dbReference type="GeneID" id="18245785"/>
    <dbReference type="KEGG" id="cten:18245785"/>
    <dbReference type="eggNOG" id="KOG1098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_8_1_1"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="25"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="236"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="597"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="569"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="819" mass="93889" checksum="888EEC11D97C3EA1" modified="2011-11-16" version="1">MGKVQKKNSKGRLDRYYHLAKEKGYRARSSFKIIQINEKYGHFLEKSKVVIDLCAAPGSWCQVASQLCPINSLIIGVDIVPIKPLPKVITFQSDITTEDCRSKLRGYMKTWKADTVLHDGAPNVGLGWVQDAFTQSQLTLQALKLAVENLSNGGTFVTKVFRSRDYNNLMWVFSQLFEKVEATKPPASRTVSAEIFVVCKGFKSPKKLDPRLLDPKHVFEELPSGPQNNEAKIYNPEKKKRQRQGYEEGDYLLYHVMPLLEFVKNEDPINTLGDLNKLSVPSKEDEETEFKMVKKLKSFTPELQECIKDLKVLGKKDFKLILKFRKHARELLGLDEEEAESEIEVEPLTEDQRIDKELQELRDKHKQKSKREKKHKNELKQKEIQRMQMNMLTDMNIGIEGATSDSQGLFNLRSAEKTGELNKLIQGKKRMIFNEADRIRDVEIDVGDNEEVGTDDELDGLEAQLDDMYHSYQEKRAERDAKYRAKKLRGDEDDEPWDGIHSEEENDAEEKDYEMDDQSESDSDDDEHINRLIEEKRGKDGLSKSAKNFFAANSLFEDVNEDALLAAMAPKTSPVDVNGDDRKLAADSESDESDFASDSDSSFEIVREKNEVSEDEDSSDEETHKFKNLSEKEKNDLATVEAMTLAHQLALGHKTKHDLVDEGINRYSFRDNDNVPEWFIDDEKRHSKISKPITKEAAMAIKQKQKELNARPIKKVLEAKGRKKMRALKRLEKLKKKSDLINEDGAKSEHDKAEEITKLMKKLTKKQQIKPKVTVVVARGSNRGLSGRPRGIKGKYKMVDGVMKNEQRALKRIAKKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4C7</accession>
    <name>G3B4C7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_105821</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4C7"/>
    <dbReference type="STRING" id="590646.G3B4C7"/>
    <dbReference type="GeneID" id="18245838"/>
    <dbReference type="KEGG" id="cten:18245838"/>
    <dbReference type="eggNOG" id="KOG2913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049047_3_0_1"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29710" checksum="382046F2D6C12719" modified="2011-11-16" version="1">MPISQGAVQSLVNLAISFTPLFSYGLTSYQIYLKKTTSGFSIDVCLIMLISSICKVIYYMLEPYEISLFRQALIMIFIQVVLLKTCLRYLETPAKLYDAEKIIHSSSSPLEIVFNRLKYFDNFYKRPYNFWQWYQDHIVYWEFLVGFSLSLTVLALVFQSSSVFISTIGFLGLFSESLLPLPQILLIHRMKSVKNFKWILLLSWLGGDFVKINYLLFGTNEVSSIFMSAALFQTALDVFIVSQYFYYKNLESLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5B3</accession>
    <name>G3B5B3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_93947</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686967.1">
        <property type="nucleotide sequence ID" value="XM_006686904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5B3"/>
    <dbReference type="STRING" id="590646.G3B5B3"/>
    <dbReference type="GeneID" id="18250342"/>
    <dbReference type="KEGG" id="cten:18250342"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="105"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="572" mass="63494" checksum="DC5853807D048F46" modified="2011-11-16" version="1">MSQVTYESLLVNDPLTGYDDAKKYAEFVPKLEAYREKLINSIDPEYAIVLPKPIEELYADQFNAIKYLYDEKLLSEEELAITNSSGTDLAKKIASGELKSVTVYKAFAKRGTICHQLTNCALEIFTDEGLERAEYLDKYYEQNGTTVGPFHGLPISLKEHLFYKNKVCHGCFVGNIEDVSEVHGVTTQILENLGAVFYIRTNQPQTLMHLCSDNNYIGCTRNPYNLGLSPGGSSSGEGALVSFGGSVAGVGTDIGGSIRAPAAFSGCFGLRPSTKRISVRGGSALDAGQESVIGVAGPMTRSVDDIDMWMKHYINDGKPWLLDEQVINMPWKEVAPPKPSEFTVAIMYDNDLLKTTPPIARGLKETAAKLENAGVKIVEFKPIKSKLAYDVVHQMYTADGNIGTKACFQKSGEPIVRLTKNYLNYGKGSKGLTVTENRELNDIRNELRQEYTEFLVKNDIDFIISPTYANVAPKPKEIYNWSYTSLFNILDFPTLVFQTGLFQDPKVDKWDDSFKDYKFRSPSEELELTSYDPKEFVGAPIGLQLSGKRYTDEDVVAAGKTIVDILGVNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5B8</accession>
    <name>G3B5B8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-lactate ferricytochrome C oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_123073</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686972.1">
        <property type="nucleotide sequence ID" value="XM_006686909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5B8"/>
    <dbReference type="STRING" id="590646.G3B5B8"/>
    <dbReference type="GeneID" id="18248942"/>
    <dbReference type="KEGG" id="cten:18248942"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_3_3_1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="119"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="584" mass="63400" checksum="3EDB9AEA4D51ECDD" modified="2011-11-16" version="1">MFSRLRAAARTVRQYSTTQAPKPSSTAGRVGVISAAVVSGAAGVYFGSTYFGGRNDIYTRSTAPLDAVPPLQYADKNTYEVAIAEMKQVVGEDNWSVSEDEILAVSDLFFSTHRPPKPAENKPSIIISPADTQQVSQIVQIAHKYRVPIVANSGMTSLEGHTMHTRGPYSVSLSFSRMNKILEFHPDDLDVVVQPAVGWQELAEFLQDHEKGKRLIFGPDPGMGATVGGMASTSASGTNAYRYGTMKENVVNMTVVLADGTILKTRQRPRKSSAGYDLTRLFIGSEGTLGLITEITIKLHVKPVYEYVSIATFPTMKDATKTASTIVAKSGLQLNAIELLDTTMVGFVNAGGITDAKGRPKVFLEKPTLLLKIGGPTKESIHQDTKLVQQIAKDNGVVKFESSTSEEENALLWSARRNGLFSTIEHGQKVLDDPNDVQCWTTDIAVPLSNLPDVISETHDDLNRSGFKGKFATMGHIGDGNCHFLLLYNKKDYGKAQAAVDRMVERTLQFEGTCTGEHGVGVGKRRFLPVELGQPAVDLMRKIKYSLDPHAVLNPDKVVKLEAGDPLDELLEAGHVAESGKGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5D5</accession>
    <name>G3B5D5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase I associated factor, A49-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114509</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5D5"/>
    <dbReference type="STRING" id="590646.G3B5D5"/>
    <dbReference type="GeneID" id="18247456"/>
    <dbReference type="KEGG" id="cten:18247456"/>
    <dbReference type="eggNOG" id="KOG4183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034953_2_0_1"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="411" mass="46291" checksum="47B7BE8DA7627C0E" modified="2011-11-16" version="1">MAGTKRKANDDSYTNVAIKEYSQESNMVVGAFFNGLSVDSSTEFDVYKHKSKNQFELHGENDTLEYNAGSNEDEEAHAYTLAIYDPSTKSVELYESPMLNGRVISKSKRQYKGPKVKQLGIRNNLQRTALGEAFGTKKAKSAISNLERNRIDSDKLQDVELDIVDSVRESTQALPTKVQMDQDSSELRPTPRINMEATSSDDIYPVENIIPSPDWDAIRINSILDAPTTDSKLELLPFSSSDYIRHHIDAEDQTKLKFIYYLSILLGIYHNRRSRDKATLLTKFKTQPSEMLIDTILKTFTVSKSGKFGKSKDKSFFIDPHNEDKLLCYILAIIFHVNNFLIELQPLAYELNLKPNKLVNLCRIMGANVKPPTVGQAEALSIPKALMATSKLASLKAPVRLPDMSKRGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5D9</accession>
    <name>G3B5D9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_114510</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687376.1">
        <property type="nucleotide sequence ID" value="XM_006687313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5D9"/>
    <dbReference type="STRING" id="590646.G3B5D9"/>
    <dbReference type="GeneID" id="18247457"/>
    <dbReference type="KEGG" id="cten:18247457"/>
    <dbReference type="eggNOG" id="ENOG502RSH5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030508_0_0_1"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011938865" evidence="1">
        <location>
            <begin position="16"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="302" mass="34898" checksum="D385B74316515F11" modified="2011-11-16" version="1">MLVLKLLLCITFVVSYPVSLDLSQSLDFQVISSNVRTDTKWRFCHEHRWKERKVQLIQTLHHHATSKLPTLIGLQEVKHNQLMDLEEGLNHLTDGKDWDYFGVGRDNGKKKGEYAPIFYRKSQWELLNGTTEWLSPTPRLPSKAWGAADVRIVTITTFKNKETGIIINMLNTHFDHKSQLARGKSSKLILDWIHQIPNDHETFVSGDFNSQSSDASYKTLIQDLSDTRKVSRVKDTQMATYTGFEPEDPSTVIDFVWCAKDANKENSHTSVNKYNVLDTWTERGYRYSDHRPVVVEFSVKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5P1</accession>
    <name>G3B5P1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_106399</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5P1"/>
    <dbReference type="STRING" id="590646.G3B5P1"/>
    <dbReference type="eggNOG" id="KOG0536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046313_2_3_1"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="73"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="150" mass="16823" checksum="6EBE50951C09B11F" modified="2011-11-16" version="1">MGSNTLFPGPNSFQRVDRSDSLAPNSTAINARQRQKVVLEPGHSPLDWANLNSNSSQRYKLRGVPPNTPPPQYVTVTKDELKLHNRKDDAWTSINGKVFNITSYIDFHPGGVKQIMKCAGRDGTQLFNKYHAWVSADRMLSNCMVGMYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5T0</accession>
    <name>G3B5T0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114594</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5T0"/>
    <dbReference type="STRING" id="590646.G3B5T0"/>
    <dbReference type="GeneID" id="18247496"/>
    <dbReference type="KEGG" id="cten:18247496"/>
    <dbReference type="eggNOG" id="ENOG502RZ6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130029_0_0_1"/>
    <dbReference type="OrthoDB" id="4079278at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="161" mass="18150" checksum="2537D970172D4121" modified="2011-11-16" version="1">MFRNMMIGKLSIQREFARGIAMKGDVHLSNRRVMRKIKLGKARPAIFHQFETLVELSDGSVIKRRSQAPKDEIRMINDQRNSVLWNPNRSDLVAVDPNATGKVNKFNQRFASFSPSIEATSETSETNSTQKDGLIELLGQNVKEVASGGKLFDKKQSKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Y2</accession>
    <name>G3B5Y2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114628</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Y2"/>
    <dbReference type="STRING" id="590646.G3B5Y2"/>
    <dbReference type="GeneID" id="18247515"/>
    <dbReference type="KEGG" id="cten:18247515"/>
    <dbReference type="eggNOG" id="KOG2924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_0_0_1"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000003">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="376" mass="41385" checksum="EF0BF2F983B1F533" modified="2011-11-16" version="1">MSQADKIPGLASDAVLKQSAPVPDSFVEVKGIDYSKDSAYNMTAIDLIASMKTMGFQGSSVGDACDIINKMRSWRGKHKSELEEHDIKGEFDDEGYQKSTIFMGYTSNLISSGLRDTLRFLVQHKMVSAIVSTAGGIEEDIIKCLAPTFMGEFSLPGKGLRDQGMNRIGNLLVPNDNYCKFEEWMVPILDKMLEEQQEELEKNGADAFDNTAGVWTPSKFIDRLGQEINDETSVLYWAHKNQIPIFCPALTDGSIGDMLFFHTFKASPRQLRLDIVADIRRINSMSMEANNAGMIILGGGLIKHHICNACLMRNGADFAVFINTGQEFDGSDAGARPDEAISWGKIKADAKQVKVYADVTVVFPLIVAATFAAQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B631</accession>
    <name>G3B631_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="3 8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114676</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="3 8"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B631"/>
    <dbReference type="STRING" id="590646.G3B631"/>
    <dbReference type="eggNOG" id="KOG3396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072095_3_0_1"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000136">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="13"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="155" mass="17622" checksum="E5FDD98B87300D67" modified="2011-11-16" version="1">MPYTKEITLPEGYTFRRLEKSDYNNNYRETLQVLTTVGEISESKFNDLFENWNALPNIFHPHVITNEQGKVVATGMLFVEKKLIHECASLGHIEDISVAKSEQGKKLGYSMIVGLTKVAQQQECYKVVLDCSPHNVGFYEKCGYGNGGNNMYIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6C6</accession>
    <name>G3B6C6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF383-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114741</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6C6"/>
    <dbReference type="STRING" id="590646.G3B6C6"/>
    <dbReference type="GeneID" id="18247560"/>
    <dbReference type="KEGG" id="cten:18247560"/>
    <dbReference type="eggNOG" id="KOG2973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037769_2_1_1"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="96"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="289"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="367" mass="41983" checksum="C53863CD8D21CDD6" modified="2011-11-16" version="1">MPTQLEELVEFLHSPQPAVVSIALDNLVGYSQGSHQSVFAYNNYESVTDLKKLAQESGKVTVSQSVTILANLCTDTKVRDLIVEDADFLKFLVGSIIRLTNMSTDLMCILLTNLAKNDHITKVFDFDLEHTPEQAKVFKSTKAMDCLMDCFVKGFDRTLNRYASFDYLAYFFADISRFTRGREYFITEQSYDEVVPISKLLVFTEKYDSKIRREGVASTIKNSLFDASKHAELVNNAKINLLPYILLPIAGPEEIDEDDMFDLPEELQLLPSDKKREPLKGLICIHLESLLLLCTTREMREYLRGKATYALVREVHKVHMEDDNIVDLCDRLVQMLMRDEANEDEQKVEEVDMEEDDSDDDAIVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6T4</accession>
    <name>G3B6T4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_105866</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6T4"/>
    <dbReference type="STRING" id="590646.G3B6T4"/>
    <dbReference type="GeneID" id="18245846"/>
    <dbReference type="KEGG" id="cten:18245846"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_4_3_1"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="269"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="280"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
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        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="400"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV63014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="440" mass="50028" checksum="6E4E27990993FF05" modified="2011-11-16" version="1">MRLLRYYSILPKPNLEIRSIITNKDAYKDSILKRETKNLLHNLETVASQRPQELELIARLNSLKHKRAQITKSITPENKQTVLPQLADIKKSIKSLEPKVDELSATVLANAEALPNLIDPSVKSHQQVVEYLNVLETEIPSPLPEDDETLRVFDHKTIGERKGIFEFAKASKISGSSWYYLVGDGALLENALVQYALAQATHHHYQFVIPPTIVKNEVIKACGFKPKDQHNEQQIYEISDSDSSLIGTCEIPLAGYHANINFQVSEQFPKKYVGLSRSFRAEAGSRGRDTKGLYRVHEFTKLELFHYTTPESSALELEQLMEFQKSLIKNLGLKAKVINIPYNDLGAPAYKKYDIEAWMPGRNSWGELTSSSNCTDYQSRRLNIRYFDQEKNLKYVHTLNGTAMAVPRVIVAIVEQNYDPVTDQIKIPDVLVPLMGKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6V0</accession>
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        <submittedName>
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        <name evidence="2" type="ORF">CANTEDRAFT_93799</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
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            <taxon>Saccharomycotina</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="273" mass="30635" checksum="3544A90DD9254783" modified="2011-11-16" version="1">MSEIHQEAVKLNQQHFDAAKVHSYDRKDLTQTISKLAPYMLLSYPKLKFEPGFDYTILPKTSPIFNPIKTYMDFACGTGIVTQKLVPYVKNVIGIDINEEFLEVFSNRLGNSAKAYLLDLLDTSKEKQVEQFVASADIITCTIAYHHLGDYESITKKLVSFLKPNGHLFVLDFYNPDVEKTSSDRVKVSPAAKHMGSLKKSALQETFSDAGLSDITVDVNVTTKVWLEMKFILGHCTEALQEQAKLGRLAHKTVDGIEMYHAEVSLVLAVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B844</accession>
    <name>G3B844_CANTC</name>
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        <recommendedName>
            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_108011</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="55"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="197" mass="22988" checksum="523D8579A95B782B" modified="2011-11-16" version="1">MFLRPVSTPNVIRHTFSWDLWSRRCVPAAFYSSQAFSEAEITKAKQWHQQFTASSIPIKEFEVAYSRASGPGGQKVNKTSSKATVSLAPDRWLNPQFCYWIPAAIRSQLKTNKIRYETKTGGVLIQSDTSRNRDVNTTECLNKLLIEIKKVAYFEEEMTEEDKKKWEELKERSREKRLIQKKRTSDKKKSRSKNFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B847</accession>
    <name>G3B847_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Decapping protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_115810</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B847"/>
    <dbReference type="STRING" id="590646.G3B847"/>
    <dbReference type="GeneID" id="18248031"/>
    <dbReference type="KEGG" id="cten:18248031"/>
    <dbReference type="eggNOG" id="KOG2868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113008_0_0_1"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09804">
        <property type="entry name" value="Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="184" mass="21375" checksum="CF51CD77A6AB7EB8" modified="2011-11-16" version="1">MAKTKKPESGQQETLSRKKALELYKTTINFNVINRYDPAVKKLLYNTSYCVVYKFDDSTEQWNKTDYQGTLTLYLRSFQVSQQNFEPTLQSLQNLFCYGLILLNRNNPECFSIGLLPNNVTKHYFPRGVDHNGISQMDVELNDNLIIVKSLLGDIYGLWVFNEVDRMKLFKLLQFCLTTDSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8B6</accession>
    <name>G3B8B6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_131235</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687903.1">
        <property type="nucleotide sequence ID" value="XM_006687840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8B6"/>
    <dbReference type="STRING" id="590646.G3B8B6"/>
    <dbReference type="GeneID" id="18249505"/>
    <dbReference type="KEGG" id="cten:18249505"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000012">
        <property type="entry name" value="Transketolase, variant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="364"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="697" mass="77449" checksum="3F33867D9C725CF0" modified="2011-11-16" version="1">MTVPESLQNRSQTHQYVLKIFRVLIADLVQQFNGGHPGGAMDMAAIGIALFKYVMKYSPSNPDYFNRDRFVLSNGHTCLFQYAFQHLVGYSHMTMEQLKTYHSSELESYCPGHPENEFPGIEVTTGALGQGISNSVGLAIASKNLSATYNRPGFEVSSGHIFCMVGDACLQEGVSLEAISLAGHLGLNNLTVIYDNNQITCDGSVDLTNTENIKKKFEACNWQVLEVQDGSNDVDGIIEALETAKKSEGNPTLIIAYTQIGIDTSVEGQAVAHGAAFGQSEVDNLHTLYGFDPETKFFVPETVYQFFADVVPRGKQLEKQWTELVHDYSLQYPELALEFENRRLGKLPPNWQSFIPNSFPTTPTPSRKSSGLVFNEVAKNVNNFIVGTADLSPSVNLIWKGKTDFQNPRVKTSCGINGDYSGRYIHYGVREHAMAAISNGIAAYSPKTFIPVTSSFFMFYLYAAPAVRYGALSQLQVIHVATHDSIGIGEDGPTHHPIALASLYRSMPNMLYIRPCDSTEVAGAWEHAIEADNTPTIISLSRHNLEQYPQYSRKDKVRLGAYKFIENAGAVINIISTGSEMQFAVEASQVLAQKGIIANVISFPCQRLFEKQPLEYKRSILNRGKVPSVVVEAYAVNGWERYATAGINMSTFGKSLPGKMAYEYFGFNSERIAAKIEKYYEDWKQDESLRFEFQDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8E7</accession>
    <name>G3B8E7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_115841</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8E7"/>
    <dbReference type="STRING" id="590646.G3B8E7"/>
    <dbReference type="GeneID" id="18248047"/>
    <dbReference type="KEGG" id="cten:18248047"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="82"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="393"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="610" mass="68143" checksum="6970E4268D772ABF" modified="2011-11-16" version="1">MSAVSASKAKREQKRLEREAKKASEGKATKKTKKQIAKDAEEKDVDDAEAQIAKLKLQTDEDGISDRVTTGVLSSLVTSRDIKITSVSLLFHGKVLIQDSVLELNYGRRYGLLGENGCGKSTLLKSIAAREFPIAPHIDVYLLNEPAEPTEFSALEYVVREAEGELKRLEDLVEETIVKSGPEDPVLEGLYEKIDEMDPATFESRAAIILTGLGFDKVTIKKHTKDMSGGWRMRVALAKALFVKPTLLLLDDPTAHLDLAACVWLEEYMKRWDRTLILVSHSQDFLNGVCTNMIDMRMKKLMAYGGNYDSYLKTRTELEVNQMKQYNKQQEEIAHIKKFIASAGTYANLVKQAKSRQKILDKMEADGLIQPVVPDKVFSFRFADVDKLPPPVLAFDDMSFSYSGKPEDNLYENLDIGIDMDSRVALVGPNGIGKSTLLKLFQGILQPQKGRVIQHTHIKLGVYSQHSADQLDLTKTPLEFVRDKFSSVSQDFQYWRQQLGRYGLTGEGQTSQMATLSEGQRSRVVFALLALESPNLVLLDEPTNGLDLSTIDSLADAINAFNGGVVIVSHDFRLLDKVAKDIFVIENKTATRWEGSILDYKKKLAQAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8R4</accession>
    <name>G3B8R4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_126343</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8R4"/>
    <dbReference type="STRING" id="590646.G3B8R4"/>
    <dbReference type="GeneID" id="18249164"/>
    <dbReference type="KEGG" id="cten:18249164"/>
    <dbReference type="eggNOG" id="KOG2030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003612_1_1_1"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="527"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="9">
        <location>
            <begin position="837"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="790"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="942"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="270"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="969" mass="111050" checksum="49458A5FA900E2BD" modified="2011-11-16" version="1">MIVEFGNRIHFTDYERNIEPTPSNFVTKLRKHLKTRRLSSIKQIGDDRILVMEFSDGLFYLVLEFFSAGNIVLLDHDRKILMLQRVVDSNDDKFAVNETYNMFDRSLFEQEPEPYVKRQYEVEQINSWIEKEKTKVEDNQNRLKELANSHTPTKLKKSKIFSIHKLLFVNASHLSSDLILKTLNENGIRSSSSCFEFHDSEMLSTIVATMNQCEDEYVKILQGGEIEGIIVSKKNTNATEETAENLQYLFDEFHPFRPFKDGSLYKFTSIQGYNKTLDQFFSTLESLKNEIKIENQKQLAMKRLDKAKNERVKQIESLINEKNANIKKGDLIILNANLVSGCIDFINGMLEKQMDWHDIEKYIELQKSSGDDITNAIQLPLNLLENKIKLNLPDTDVDENVESSETSSSDTESESDSSSSDSDSDSDSDSDSDSDFRGTKKSKSKSKKTKSVPTISVWIDLSLSPYANASTFFDSKKSAEVKQLKVEKNTGIALQNAERKITHDLTKALQNESEALNKVREKFWFEKFYWFVTSDGYLCLSGKDDLQNDMIYYRYFNDDDFFVYSDIEGALKVFIKNPYKGETVPPSTIWQAGMFSLSNSESWSNKSSSSAWYLPGPGVSKKDIDGSLLRPGKFNFKGKKEHMPPVQLVMGFGIYFVGDDETTKRAREKRLVRQEEMGLQLSNDNKKQDIDQSLIREKIMEQERKEREKEAVVDDDEESQQDDAANDSSIVPSELDSGLQNLLIVNKRGKKGKMKKIAEKYADQDEEDRILRMEALGTLKQVEENRKKQIEVEQEQQNKNSKYENQDKIQQRKQKQDEKELRKYLLQDMADKQNEIEYLSIFDGLIAKPTKSDTIVDFVPVFGPWFSLQKFKYKVKIQPGNNKKGKSISEILTYFNGRKVDKSKEDNELDWPEEHEALKGAKANDLIAMVPVSKLKVVLPAASGKADSGKGKNGKPGQKVGGGKKKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8S7</accession>
    <name>G3B8S7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_136356</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8S7"/>
    <dbReference type="STRING" id="590646.G3B8S7"/>
    <dbReference type="GeneID" id="18249965"/>
    <dbReference type="KEGG" id="cten:18249965"/>
    <dbReference type="eggNOG" id="KOG2042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003224_0_1_1"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="971"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV62419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1055" mass="120533" checksum="CD7D4AF1467F3387" modified="2011-11-16" version="1">MSADDIRAKRLAKLGSRIPNPTASTSASNNNPTVVPESNELPVSSEPEKKKVSLDTTQRQKLPSVQPPTPVPKPVATVPPEQDIANWFTFHLKDIFKVSLVPSKDLVYVESVAHELQESGRLVSGDDLESIFMEVLSELGVPRPFKTTIDYLFHIYNESLRLRNRLSKKEPNLEKKTALVHSITQFSCNYGYICFQVGDMFINNDLQSLTNTFINSSSTMSGFLTDIVYESIEQDGLLDMLNLLFPAISSQLGRINLHDPSYNKYLVIFKTLVGIKQVAAVFSQVVGFKPPNSEEGLDFECKTLLGPLLRLSPLADKVGVSYFGEGFDDNNFTRINSAYDSINVEFKLIVDQLFEIVNKLIRGSPETRNSVMKWFADLVNVSHLRTGSHSDPAKLAGDGIMFNIFVILTRLSGPFLEYPLYSKTDKIDLNYLVNKQCLVDLKEETRVNSTLAESGEYVESFSSQEKPNFISDCFYLTLTYLNYGVGGISVKYDKLKNQIKQLKERIAMIENRQVPQGTNPMMMQFLGQQLPTLNKQLSLLNIKKHTVKALFNSRDLQLEIFDFIVGATVFITKVIDPSHQHPQTKLKIPIFKIDRVSQLDDQDFLRTKCPSPWKYFPEFFLEGMINYCKFTTHFRGCPLVRNDQKLQLFIEFAIILIRCPEILGNPHMKSNIIEILFIGSLPMQDGSPGFLADIFISNVLVRDNILYSLLDLYVMVEKTGASSQFYDKFNSRYYISVILEELWKNDVYKNQLTKYSTSNIEFFVRFIARMLNDTTYLLDETFNELNSIHNFQQEIKRRQGGQPGDEQEFGSTDDLLKNLQSSEKKAESYMGLSNKTMELFKLFTKHVPRGFMLPELVDRLAGMLDYNLEAMLGPKASNLKVEDPTKYHFNPREILQSLCEVYYNLAHEPEFVKAVARDARSFNVNWFYKAERILSTKTMTDSKTISRLVEFAKNAEKQRLEDENDELELGEIPDEFLDPLMFTLMEDPVILPSSRVSIDRSTIKAHLLSDSTDPFNRVPLKLEDVLDDFELKDKIEAFKRSKHNPQTSTPMEIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8W7</accession>
    <name>G3B8W7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115235</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8W7"/>
    <dbReference type="eggNOG" id="ENOG502S0YB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027158_2_0_1"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="409" mass="46612" checksum="55F0856972BD0B4F" modified="2011-11-16" version="1">MSQIQSLLDELEPKLFAESNVAKIWGVAQQKLDDPQPPIEYPEYSFNRYSYRPVDYWTAGFFPGSIAAVLERSEKYPHKYPHDKLHAVKLEYAAKWWTEGLMGQVPRTDTHDLSFMIYPAFLREYQRSKSPKTFESLKTAAHALASRFSPSAGVIRSWDTAVNKRYSFTDLDADFIVIIDNMCNLNMLYYVASQTGDLSLSTIATTHAENTLQHHFRHPEWSSYHVVNYESSTGKPKAKFTNQGYEDESTWSRGQSWAILGFAETYSWTKQKKFLDAAINCWEFFASKLPQDGVPPWDFDAPDPENRDTSAGLIAALGLLTIYETTKQQKYLESALKLVADIVRLSFVDGAKFNEDGTVDFGEYDTILKDATINNNPDTFKKLVGHGLVYGDYYFLSIGNKLLELGLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8X7</accession>
    <name>G3B8X7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_115240</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8X7"/>
    <dbReference type="STRING" id="590646.G3B8X7"/>
    <dbReference type="GeneID" id="18247787"/>
    <dbReference type="KEGG" id="cten:18247787"/>
    <dbReference type="eggNOG" id="KOG1446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044117_3_0_1"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="358" mass="39558" checksum="DB8F722073749ACA" modified="2011-11-16" version="1">MSKKSSSTILVDSQTLSSLMPRKTFDYHSGASITSLNFDDSGQYLISAGIDKSIQLYDVHKGIHTKDIQSQKYGAHLAKFTHKDLNCLYASTPEAVPQDEPIDHAIRYLSLSDKKYLRYFKGHKSQVVSLEVDPVHDMFITSSFDKSVKLWDLRTSNPTGSVEVGQPVLLAYDPHGIVFVTAKLPGYGGGDGVGELEFYDTKNVHQVPFLRSTIHTRPECTWTNIEFANNGKYLLLSTNTSEHYLIDAFSGRLLTRLVMQHPNYKLNSHYPVSHTSCFSSCGRYVIAGSSVSELSVFDLVGIQSSNGSATVKDSDNPSTLSPFKTISTNQGIPKLIAFNPKLFTVATADNSVTLWQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B958</accession>
    <name>G3B958_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maf-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115932</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B958"/>
    <dbReference type="STRING" id="590646.G3B958"/>
    <dbReference type="GeneID" id="18248087"/>
    <dbReference type="KEGG" id="cten:18248087"/>
    <dbReference type="eggNOG" id="KOG1509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_2_1"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="206" mass="22773" checksum="71980BD04FA555C9" modified="2011-11-16" version="1">MSVLDLSNYSIVLGSSSARRLSILQEVLKITKVTVVKPDFEENLPKSMSPKQYVQQTSHHKLLSILDANTFESPTIVICCDTIVDCNGQILEKPQTKVVQRQMLNSYRLHNAINVISSVHVAIVHGKDIHVAGDEVCTTLNFDSSTPQEVIEAYIESEEGLEVAGGFKFQEAGNVLFSSLKGDYFNVVGLPAKRTFDLVRQLLGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B997</accession>
    <name>G3B997_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115294</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688853.1">
        <property type="nucleotide sequence ID" value="XM_006688790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B997"/>
    <dbReference type="GeneID" id="18247810"/>
    <dbReference type="KEGG" id="cten:18247810"/>
    <dbReference type="eggNOG" id="ENOG502T3GY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585391_0_0_1"/>
    <dbReference type="OrthoDB" id="4078100at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024274">
        <property type="entry name" value="APC9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12856">
        <property type="entry name" value="ANAPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="462" mass="52280" checksum="189B43488EA84ABC" modified="2011-11-16" version="1">MNSRRIPSQPNTDQSFLNPNDSSFLAHNTTSRSVSSSTSMVSTPSNHIRKFHQNVPQDQGDGHKPDKFRSSTNIVSKSKNNHHHLKPKKSSNVDLVKNKLLNLHKSSRIYTKSKSISEEDAMRSHPNFTTKSFILRKPLHMNLYDYSVFRSYPDASAGDDKLPPAVKESQIKAWESAEKITNNLIFDNDSDLSDDEDINEGETHHDIAGDMVRPLDSSSVPAGGDDTIIKSIPGFCKDEVDVLQTRFLHLQTLTASTTPSIAAYDEEERKVLWNHRQEQQALQGKHFGQYSSLTSKRKAQVQQKKDMLNRIFGYNNTLNHEYITNNTSYSALDSVMNTSKSYQEDKEEMSQLLAEDKEYHASLEESKANLRLARSVHLYNGDDSFHLSILNKKLNVAGAGVNEFDHYKYLQMISNKLTGVYGKHGTMKHDAGGAHDDLTAFAMSYLRRCIRHEPDGHDHNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9D8</accession>
    <name>G3B9D8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_107430</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9D8"/>
    <dbReference type="STRING" id="590646.G3B9D8"/>
    <dbReference type="eggNOG" id="KOG2773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018299_2_2_1"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="159"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="370"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="479" mass="54380" checksum="CA33A098185904EA" modified="2011-11-16" version="1">MGKKTLADELLELHKPQTDFDIENDEFANVSSSNEAEESSEDELKTDHYVKVSKSKLRKHEPKNIYGGQVSSRKDIFEGDDDNEMITSEEDEDIKLSDSGVSLDNYQSDSESEDQEDKEEPEEPEEHLEDEHKRDALKLLISKERQTIGKRVAQSSINDSLKGFSIINQNSLFDKLIESRIKLQKAVSKSNILPKDSEAAKPFTTSRTKTAVKSAQEKCYDLLDNIMQLRNTLYKKDSIETVTFPKKRKLNNYAQAAGEFDSKLNNFRSITLTKWSNKVMSSSGSNALNAGKFKVVNQSAEQQVVNNLNDVERLKKRTYLNRSGVIPLGYKEPSEEGNDEEEEANPDIPKEVVTKGKNEMPQIFDDEDFYRVLLNDLVEKKISSSNPVNGVTMTLRQTQKAQKSNKNVDTKASKGRKLKFNIQDPIAHFETPLNLKWEDFQIDELFASLLGQKVNMDEADEVALEDAEIINDDSIKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9F2</accession>
    <name>G3B9F2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_131342</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9F2"/>
    <dbReference type="STRING" id="590646.G3B9F2"/>
    <dbReference type="GeneID" id="18249514"/>
    <dbReference type="KEGG" id="cten:18249514"/>
    <dbReference type="eggNOG" id="KOG1301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016216_3_1_1"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="636" mass="70977" checksum="791BD07145253EDF" modified="2011-11-16" version="1">MSLQEDNCLRDRQIATLERMLHLNKDGSADLTLAVPSSQGDDLVWKALVLDAKSQSIISSVLRVNDLLRCGITIHSLISSPRSRLADVPVIYFVEPTPANVSAILDDLAADRYDDFYINFTSSLPRALLEDFAKQVSLAGKSTKIRQVYDQYLDYVVTEQSLFSLDFPNTFTRFNHPSTKEDEIHHLAEVLSSGLLSVVLTLGSVPVIRCQRNGPAELVATQLDLKLRDHLANSKSLLSSQSSIHQRSVLVLLDRSVDLSSMFSHSWIYQCMISDVFRLKRNTVRVDGKDYDLDPKDFFWNKNAQLPFPDVVENANVELESYKHDAHELTARTGITSLNDIDDNDHNDTGKIQQAVNALPELTARKATLDMHMDVLASLLKELEAKSLDRFFELEQSYNNPKVQAQFLELLNEPSKKNNIADKLRTFIILYLLVDNLSSSFVDEVKAKFNQLDPNLDLSGLKYIEKFKQISKLSNMASLGEIEAPGELSGGSNSALFNNLSSRLYGLTEGRLTEGLSSLTSGLKKLLPNKKNLAITSIVEAFMDPTNASGASVQITDDYLYLDPKLRGGHSKPPKRQSYKNSIVFVVGGGNYVEYQNLQELAESHQGINDIIYGSSDIVTAQEFLDECTELGRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9H2</accession>
    <name>G3B9H2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_125169</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688055.1">
        <property type="nucleotide sequence ID" value="XM_006687992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9H2"/>
    <dbReference type="STRING" id="590646.G3B9H2"/>
    <dbReference type="GeneID" id="18249086"/>
    <dbReference type="KEGG" id="cten:18249086"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_1"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05262">
        <property type="entry name" value="SDR_a7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="298" mass="32059" checksum="B53EDC14911ECDF9" modified="2011-11-16" version="1">MKVFVTGGSGFIGTKVVEQLISKGHSVVGLARSDTSAEKLETAGAKVVRGELTDIDVLVDAAKSADGTMHLGFIHDFANISKSMVLDRQIVTSICEAYKGTDKFFINTSGTLFLHGPGLNDEDTPIPEVPLLPDMVVRTETESQLLSYADKGFRVISIRCPPTVHGEGDGGFIPIIYGMFKNQGASFYPDSGENVWPAVHRADAAKLYVLAAEKAPTGSILHAVAEQGIPIKSIAEAMAKKSGFEAKSVSKDELKEKLGFFFGFVFASNNYVSSEKTKKITGWAPTEATLLEDITNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9T1</accession>
    <name>G3B9T1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_108665</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9T1"/>
    <dbReference type="GeneID" id="18246051"/>
    <dbReference type="KEGG" id="cten:18246051"/>
    <dbReference type="eggNOG" id="ENOG502QR9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018056_0_0_1"/>
    <dbReference type="OrthoDB" id="4024171at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="528" mass="60333" checksum="F14CDFCAADEC0D61" modified="2011-11-16" version="1">MPSSDVLASHENEQIPNIPFVSSDEYELSSATSIALSESDTLNEDRSQRLDLQETFNDNFDHYLPFVLRRLRLRSLNETAQPSPDVQDMVDYDDQPTINEEDIYGTRENEVSILGVNPSSLNLKRRFIIAEEFIKGTTYVFPSEDSFARFKELRSAHKKNRKGSVTLFDKVGNPKIVATGSRSKDDEAGEIVDPRNHIIPLDQKLKGVGLPLFKVSVPYFSNFKKNAPYMVFHKYKELPSPPNFDENGDLIDNEFETFQFCTVYTKRYQEVKRYLFEFNCEEPFKVVAFQHCLKPFVDFNYKNTRFRVIGTPVVSTYASVYNPNLKLLIVDSSKPSLCDSIINKKPGFEISSFMKKKNKSKKEDQQEDYSMLAPEEYPNPYPDPGNPLLRDEFSLLYGGLGYSNNREYIPDELPPFGEFKDCLAYKIKMSLIPKKYSEVGRVEVYQVNRNHEFYPDNPNDNYNTNSTKSVTLDNLVINCILMTLRETSVRSTARPSSQSVLLASRIGGYRQSAPGLGAASFGDFTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA97</accession>
    <name>G3BA97_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114864</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA97"/>
    <dbReference type="STRING" id="590646.G3BA97"/>
    <dbReference type="GeneID" id="18247613"/>
    <dbReference type="KEGG" id="cten:18247613"/>
    <dbReference type="eggNOG" id="KOG0284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_77_1_1"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000069">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056154">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23383">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT140 first beta-propeller" evidence="10">
        <location>
            <begin position="81"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="463" mass="52219" checksum="46CEB7C53D544F01" modified="2011-11-16" version="1">MSYNRPDNDRYAVYQQNIEQQLASQGRKAAHRRIVDHGNNMGRWYLLRSIGLDAQSIGTIRPESSYLIDLLPSPAYSNYNSNKNNLSVFDTQTKFVHLSSNKEKHTISAVKWTPEGRRLLVAAHSGEFTLWNGMTFNFETITQAHDSAILALKYSHNDEWLLSGDQDGTVKYWQTNFNNVNILNCHTDGIRDISFSPNDTKFLTCSDDSTMKIWNFNNGKEEAHLTGHHWDVKSSDWHPNLGLVVSGSKDNLIKLWDPRSGTCISTLHGFKHTVTKTRFQPNGMQRLLASVSRDRSCRIFDLRTMKDLIVLRNHESDLSCVEWHPLHPSMFTVGAYDGSISHYLLDSYIPDDDKEQINTISPSHTIPYAHEKSIHALEYHPLGHLLCSAGADRSARFWSRSRPNDPMAFQDALYTNDKNGAWYYQANNNVNAVIAPPSNGVGAATSAAQVPGLSSIPGLNFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAA2</accession>
    <name>G3BAA2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114866</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAA2"/>
    <dbReference type="STRING" id="590646.G3BAA2"/>
    <dbReference type="GeneID" id="18247615"/>
    <dbReference type="KEGG" id="cten:18247615"/>
    <dbReference type="eggNOG" id="KOG2754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031804_1_1_1"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010753901" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="258"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="425" mass="48275" checksum="864C601EC5124DD2" modified="2011-11-16" version="1">MFITRLVALLSLVFLAVAERSLVVYDSVKIDLAEPPIELKRVVETFKSLGHEILLRGYQDSDLLMFVSGYAIFDNIVFLPTSSKKINRKEQLNKQNLVDIAKTANLVFVGDSNYNYPDVIREFLNEAGIYPSPKGYKLIDHFEASDKVKLTKDNIGCARILSTIDTEYDGQSAILSNNENLVPILTASKTSFSSNDNINPVDNENSWGFGQQSHLAVSLQALSGTRITWVGSIELLKQELLLWAIGQRNALKLQFVQHHKADEPQNLDSTLYRIKDQVVYTIGVSELVDGQWKPFVVENDEETLQLSFKMLDPYQRLNLQPLGEASSVEGSKVLDTYVYSVNFTIPDQHGMFTFELDYKRPGLTYLLEKQVVAIRHLANDEYKRSWDITNAWFYVVSAVLVVIAWFFFVVNFLYVSKVDVGKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAU3</accession>
    <name>G3BAU3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115567</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAU3"/>
    <dbReference type="STRING" id="590646.G3BAU3"/>
    <dbReference type="GeneID" id="18247919"/>
    <dbReference type="KEGG" id="cten:18247919"/>
    <dbReference type="eggNOG" id="KOG2351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110332_0_0_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="41"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="190" mass="21129" checksum="754979EE67E2C5C2" modified="2011-11-16" version="1">MNVSTSAFGVRRRKPTSQVDDEENAATLKLGQEFQLHQLTNSGETEQLIALNTSEARLLIRAALKERKNKGKRPMDIEDDDDENGKEDEISNLDLAGPNSNEIIQKTLNYLATFGRFKNSSSTETVEKLLADFGSSASDPLHPFEIAQLGTLECDDSEEAKSLIPSLTNKVTDTQLQNLLNELRKYQTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAW3</accession>
    <name>G3BAW3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_124171</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAW3"/>
    <dbReference type="STRING" id="590646.G3BAW3"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009823_4_1_1"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="51"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="458" mass="52755" checksum="A99CC10C89ADC228" modified="2011-11-16" version="1">MDFDEVLMMLHHCKWQQEELMDRFYDNREKLLADCGINKSNDTVCGFNHVSSFSCSICCEDYSAVETFSLSCGHEFCINCYGSYVRTEVTLGNLIRCMIPSCNLSIPHMVTHGEYSHNVLLKAATISHISGRKVNYKWCPAPDCDGLVHLLKARKTGQSRLEDVNEFEELVDSESADLQSIPIVLCPRDHEFCYACQYENHLPCTCLLVKRWIKKCNDDSETVNWIDANTRACPSCTASIEKNGGCNHMTCSTCKHQFCWICLGEWSLHGTNYFRCNSFSSDMKEQIGEQKKVKRESLQRYLHYYKRFALHESSMKGDIKTLDKVHQKMSIFMEEQSKTNPNILSWIDVQFLQDAFRALTSGRKTLKWAYCFGFYLQKGNYADVFEQIQEYLSRSVEDLSKIFEQIIHKDNRGKSTAIIMNQKLDIMNLSSLITKRRKTLMECASSGLADGLLKLEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB70</accession>
    <name>G3BB70_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_108799</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB70"/>
    <dbReference type="STRING" id="590646.G3BB70"/>
    <dbReference type="MEROPS" id="T05.001"/>
    <dbReference type="GeneID" id="18246062"/>
    <dbReference type="KEGG" id="cten:18246062"/>
    <dbReference type="eggNOG" id="KOG2786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_1"/>
    <dbReference type="OrthoDB" id="2017946at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023322976" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023322977" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="209"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="436" mass="45746" checksum="6DBAB59474E2EFDB" modified="2011-11-16" version="1">MKSVIVAQVRFYSDKAARFVPKTGVYPKGFAVGGIHCGVKKNGKLDLALLQNQHGNAVASAVFTTNKFKAAPVQVSQRIIKETGGHGINSLVINSGNANAVTGAKGIKDAESMVTATDAAFGNGENSTLVMSTGVIGQKLPISPILKGIDTLAGSLGSSHQHWLDCANAICTTDTFPKLVTKQFELNGITYTLAGLAKGAGMISPNMATLLGFFVTDAPVTAPALRSILQYSVDRSFNSISVDGDMSTNDTIVAIANGAAGGEVIDQTSSSAVSYSKLRSEVTDFAQQLAQLVVRDGEGATKFITITVKDSLSFSDAKTIASTIANSSLFKTAMYGKDANWGRILCAIGYSDVSSSSSVLPDRTSVTFVPSDGIEPLKVLVDGEPEEVDEARASELLELEDINIDIDLGTGGGQSASFWTCDLSHEYVTINGDYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBF1</accession>
    <name>G3BBF1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor Pcc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115646</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBF1"/>
    <dbReference type="eggNOG" id="ENOG502S7CS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113770_5_0_1"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="94" mass="10368" checksum="1C0FF3CCBB8C8D46" modified="2011-11-16" version="1">MASTALSYQLEINVPFESAKQATIACNTLSPDPILKKDELTVDYTTSGSNLICLFQGVSDRVIRVAISNVLDNLKTIVECIDEFEGKEDHIFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBG0</accession>
    <name>G3BBG0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p53-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_136118</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBG0"/>
    <dbReference type="eggNOG" id="ENOG502SAHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397387_0_0_1"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="280"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="280"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="601"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="621"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="720" mass="80318" checksum="035FD55C794D8E9D" modified="2011-11-16" version="1">MNIDKSGFEDLAALFLPDISNQNLSGGSNHHRHQDHGPPSQMPSVSSTPTQPNPSNSGHTAINNNSSPQSVLRAKAEQDQHQFLSPPNSNSQSSFANFLSNNDFITWKLPPAFGTSTTSVSDTPGITQATGAQAQSSASDTFDNHAETHHVGHYSSFVPPEASLSQLHHHHHGQYFGSGSSQAGLYSKQLDPNWLTGQGELDSRMFGDPKYSLGYPQHTGQDQMDFMYQPQPQLPPNFTSDYDSVARVPVAQYQNGATAAASDEIGSKKSGKRKYQRKRNKKVPNTSGIQIDYSSAKLIKLLDLRSKKLNQDYKLLDQKGNEISVDFRGFLSGRALTNDYDNSKYILGLFEEKNEGSQIKNKTIRADPKVISCYRRNFIQVSLNFKLLGFKDYSEDDSKILKLQTSEYGYNITRVVKWFKIEITALSTASAGQPVSLVINEDSKERKEEGHLITNKDDHVVSTPISSTQQIITLNNSQITDGNIDTFFTIKKLQFKNATSNNGKFLFQNYYYLKIKLSAIVADLYYDDYIDEDFSVANSDNSRNEINLFELQSEPMIVRGRNPSFYAERKDMLVKGRLPSLKSSYLAATKVDTGDPLDFMKIDYNSSESTTDRDPQANNEGTEEGDEEEEDEDEGDDDFEGDALENENENDAPAEEPKKPKSTTPVPATSQTKSIPPGYNPNPSSLNLETIGKDGNHYKYFPISNVYYLPPINFTTISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBR2</accession>
    <name>G3BBR2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_95109</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBR2"/>
    <dbReference type="STRING" id="590646.G3BBR2"/>
    <dbReference type="eggNOG" id="ENOG502SA0F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081617_0_0_1"/>
    <dbReference type="OrthoDB" id="4095286at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32348" checksum="D58B93780C8FB25B" modified="2011-11-16" version="1">MAPLANAASSAASSAASSDKSPAPPQPPSLSSLKHRTHLPIPQGVSTASASSPSTTSAAETVVAASATAKAYRRRDSESDSSMEPRAKRERKNRPGQKFGAKKKSWVWSWFVQDSQDPNIAACDECGKVITRLASDKGSPKKLSEHLKTHKFTLETINRHRAIPIDGHGITYAPDGTPMTYQHSHPRAPASAHGGDLRMDSTSATSALTSFTDSFKAKPTPPEPLQLSYNLNQNNRRFLSPDFDNAPYSTAKFHKHLLTFLMQNKLSINVIRSHSFQQLIYDLRSDSVGELAELTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCB4</accession>
    <name>G3BCB4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="14">FBP aldolase</shortName>
            <ecNumber evidence="5 14">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_116226</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 14">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 14"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCB4"/>
    <dbReference type="STRING" id="590646.G3BCB4"/>
    <dbReference type="GeneID" id="18248206"/>
    <dbReference type="KEGG" id="cten:18248206"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036923_0_0_1"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="360" mass="39563" checksum="DD982719ED1EDAD5" modified="2011-11-16" version="1">MSVLDVLKTKSGVIYGDDVRQLFLYAQKKGFAIPAINVTSSSTVVAALEAARDSKSPIILQTSQGGAAYFAGKGVDNKDQFASIQGSIAAAHYIRAIAPAYGIPVVLHTDHCAKKLLPWFDGMLKADEEFFAEHGTPLFSSHMLDLSEEADEENIGTCAKYFEKMAKLGQWLEMEIGITGGEEDGVNNEHVQKESLYTLPETVYKVYEALSPISDNFSIAAAFGNVHGVYKPGNVQLKPSILGDHQAYAKKQIGTDNDKPLFLVFHGGSGSTQEEFDTAISSGVVKVNLDTDCQYAYLKGIRDYVLNKKDYLLSQVGNPDGEDKPNKKYFDPRVWVREGEKTMSERITEALAIFHTKNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCC5</accession>
    <name>G3BCC5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_111520</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCC5"/>
    <dbReference type="STRING" id="590646.G3BCC5"/>
    <dbReference type="GeneID" id="18246288"/>
    <dbReference type="KEGG" id="cten:18246288"/>
    <dbReference type="eggNOG" id="KOG1258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024449_0_0_1"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="74905" checksum="2F9559EA7CD5D917" modified="2011-11-16" version="1">MNGHSILPVDRHPSTPAKGPEEFERLKTEVDTSPNNIHKWDELFAKIDDRINSVNPKDVSAEFKSFIHTCYTELLDRLPFLVEHWRRFSIIEYKLNGIKSSIEVLSRSVDAVQFSVGLWEDYLNALALEKDEKYGHALEMCISLNGHHFNSHNIWDKYLEHKKDNVLPVYLKLIHIPLYEYAKYYNQFAEINKNYSLKDILGDDLEENLQRFGKTSPDECSVIESHQIIDEFSYQIFATNQTRVNAKWEFESKITTLDLNLKVSSDTESDNWFAYLDYEIQHYKQDYNTITNLFERALIPNCFNQKLWLKYLAYINVSDESHKFQVMDSIYSRCVNKFIPLDVNFVRFSYGRFLLKHNKVDLMNDYLLDLVKFFGGDNNSKLYLKSGYTETVESLLVNWSKLVGTEAFLQISQSLLECYFEESKSITAEVETVSRSTVNLLFSRLNDQSILVVIKLYLNTLLSVSDLSNPKDVNGLRQFFNKHYKRPQLRSSVSFWKFYVELEGAGMFNFSHLHQIIKYIQKETTLSKIVVNKFLNFQYNLYTSNYKRFKADVDDDSIIRYQNNLSLNPTDNKYLLASYGKSIRDIKDQFEHPGIVIDNKPDITNKLMNQNFDLFSDEFPYPATFKNIEKANAPIPFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCD5</accession>
    <name>G3BCD5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cysteine synthase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_96248</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCD5"/>
    <dbReference type="STRING" id="590646.G3BCD5"/>
    <dbReference type="GeneID" id="18250591"/>
    <dbReference type="KEGG" id="cten:18250591"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442895" description="cysteine synthase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="47"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="388" mass="41845" checksum="A6985C3EBBA05A89" modified="2011-11-16" version="1">MTTTSSILKLAAAVASSVYVLAQVAKIVRQGQNPRLTKLPPTSRGVESLVGNTPLIEIKSLSKLTGCRIYAKLELCNPAGSAKDRVALAIIRENEKSGKLTPHHGDIIFEGTSGSTGISFALLSNALGYHTHICLPDDTSDEKIKLLASLGAIIEPVKPASIVDPEQYVNAARARASAINDDQSDPRNAVFADQFENDFNWRVHYNTTGPEIWTQMQGRIDCFITGSGTGGTIAGVGRYLKEQDASVRVILADPQGSGLANRVNHGVMYDTVEKEGTRRRHQVDTLVEGIGLNRLTWNFQQGEKYIDSAVRVSDDQALKMARFLCENDGLFWGSSAAINCVAAVQTALTLGPGHQIVVVACDSGARHLSKFWAHAARLPADISLQDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCI8</accession>
    <name>G3BCI8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116236</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCI8"/>
    <dbReference type="HOGENOM" id="CLU_3032171_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="55" mass="6121" checksum="8CAA36416E0810AD" modified="2011-11-16" version="1">MSLKTRLQSLKNKLSSNKTKSSKNSTAEQIHKANKRVPQPYDKPSSPGGTKMHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCT5</accession>
    <name>G3BCT5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">JmjC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_96316</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690094.1">
        <property type="nucleotide sequence ID" value="XM_006690031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCT5"/>
    <dbReference type="STRING" id="590646.G3BCT5"/>
    <dbReference type="GeneID" id="18250601"/>
    <dbReference type="KEGG" id="cten:18250601"/>
    <dbReference type="eggNOG" id="KOG1246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000991_4_0_1"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="10">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="9">
        <location>
            <begin position="76"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="180"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="11">
        <location>
            <begin position="324"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="749" mass="86822" checksum="66A8A3C3F2547157" modified="2011-11-16" version="1">MFDISQLEECPTLRPTQTEFRDPIGYLSRPDIKNLGYHYGIVKVVPPTGWTPQFSLSSDFRFHTRLQKLSDLGIRSRSRKFFTENLNRFLTMRRRKPLELSFSVNSKTIWYYDLFVQVDNLGGYANLRWSDWQTINHHFGVHKDSIYLQNEYFVSIKAYAEFLNSNLSSTLPESDSEDELENCLLCGQNHSPDETLLCENCDNPYHIRCLGLEKVPSGTWYCKKCLVGTGEYGFEEEVDRKFSLGEFFEHSTNFQKQFFSEYGPMGLAEIEKKFWEFVEVQRSDIEVRYGADIHNLKPGQISGFPMKSTPPRIKAYFDEVEFDKYAGHPFNLTNLPYSKGSLLNYIKHSISGMTVPWIYVGSLLSTFCWHVEDHYTLSANYCHFGSTKKWYGIPASDSSKFEALMRSTAPDLFKRQPDLLHQLVSLLSPMQIVANNIKCYYANQNPNEFVITYPKVYHAGFNSGFNVNEAVNFTMEMWLEYGEASISDYKLIKKENVFNHFKLMENVLLNFSVGKESNIDLVRRCLSSYKQFIARTKMSLKALDKNFELEDLSNVISYENYLEEDNKDEVDEEELCDICQTHISHIFCVYNNRKHRFNEIAVEDSKTTKISINQLLTPESSPLEVRIAKFDRIQDKEHNVLESCDLLLDITSSSRSNLTNIKSEMNPGRNLRKSNRIIKPKKEVHSMKSKMSIINHSHSMNDLNSKIEIHLCLDCAKKFADVPTKSQLVVNITTEEMERFASSIEVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCT7</accession>
    <name>G3BCT7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_111714</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCT7"/>
    <dbReference type="STRING" id="590646.G3BCT7"/>
    <dbReference type="GeneID" id="18246309"/>
    <dbReference type="KEGG" id="cten:18246309"/>
    <dbReference type="eggNOG" id="KOG1300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009210_1_0_1"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="761" mass="87591" checksum="9140A7A9034F8511" modified="2011-11-16" version="1">MSKVKDPSSLFELQKRYLLDQIKSIQLPGNLYTLVIDDKTEALLYQVLKKDQLLRVVTSIEKIDERRKQQTFLEAIYFIDPSLYTLNCVIADAINHRYKKGWGLFLPILESDSRVYQFYHSAKFLKNPKIQNYFDFGENIHFTEASMFPMEARVFLTDDKTPNSMPIYFNENCSELVLTQVRNVAKSLVNLMVVTGEYPLIRFYSPQNQYFYKATRLSELIADEFQRQIDDYARSHHDFPPEENQGKPRSILLVVDRTIDLFAPLLHEFTYQAMAMDIVPSLERDGVYKYQSENEKGEFTEISSKVANETDEDWVNLRHLHIIESSELIVNKINELIQNNPLMVDRSRAKNSSDLMHIVANLRGFDDERKQISLHRSLIDACLDLNGERKLAEFAADFEQTCCAEGISFEGEKVKHLHDDLIVLLARDDLHINDKMRLVLIYGLYRGGLIEADFVKIAKFLGVRDTQIISLVSRCFYNLHKLGFPVVKEKLSDPKVKKKMFHTINNDGTYNTSRFGPGIKSIMQFLIRYQLDEDWFPYFRDKPLQDDIPAEIAIMNSQQATSTSLRNARIKASWAQSSNKVGQSSTKSKQRIFCYVAGGITYSEIRSMYELSNTLNKDFYIGSESILKPRDFLIGLQSIDKVKQMSDLNLNLYNELTTTKEPPLYLFESSERHHLQSRPAPGNISTQNSSRVSSNLGSANSASSSSVNQMNVDFNSFNLNSQPSSNTVPSHYQKRVSSFSTNSTTSEPTKEKKSRLKRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD66</accession>
    <name>G3BD66_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome B pre-mRNA-processing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116312</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689465.1">
        <property type="nucleotide sequence ID" value="XM_006689402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD66"/>
    <dbReference type="GeneID" id="18248242"/>
    <dbReference type="KEGG" id="cten:18248242"/>
    <dbReference type="eggNOG" id="ENOG502SAQZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149479_0_0_1"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13208" checksum="4E804A44D42C07F3" modified="2011-11-16" version="1">MSRVEIKDKIVALLKTLPKDRIQHYTSFRESQLDRFTTGTTVTDIPEKDLKLQYIALRDLANDKYKNYYKLDDKLLRPKGNPEYYERLMSEIKGEKKETFWTAIRTVVFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDC8</accession>
    <name>G3BDC8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_96367</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDC8"/>
    <dbReference type="GeneID" id="18250606"/>
    <dbReference type="KEGG" id="cten:18250606"/>
    <dbReference type="eggNOG" id="ENOG502RQ36">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071090_0_0_1"/>
    <dbReference type="OrthoDB" id="4081346at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="336" mass="38999" checksum="DB1F6381F9A2132E" modified="2011-11-16" version="1">MRSSWIPFFCRGLQQITLLMSQELSKAVDQFLAYTDIQSQHYGVPVFSHVRYGAAGDKPKHMADAEYTQKYNHFIKTLDTLSYYHEMKQLRDEQLSSIDTEYEYVIGQLPIVSESPSHEEVLTLLKRQISLKTDTLLNSYLQVMVPILRSLFHVDSNLTSSEINISRNLKFLFSKENENSSSNIHKLMQEYNINNQLSDIFAESTKDLADLYETIRPKLIEVNRLIKDIEQAKSDNLIKKSAAIKESLSSLDEKTARRKFSSLIKEWITIVSLANFLPNFIMCLPLNWYDDKVCFSIIKHCGKISEQFDNYLHLINKNKFEDLTIDDLLMIDLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDE6</accession>
    <name>G3BDE6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_117005</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDE6"/>
    <dbReference type="STRING" id="590646.G3BDE6"/>
    <dbReference type="GeneID" id="18248538"/>
    <dbReference type="KEGG" id="cten:18248538"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_2_1"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="93"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="357"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="631" mass="69838" checksum="54C57ED66232938D" modified="2011-11-16" version="1">MPRRNSNAPFHPLVGTIDIGTTSARAILFNANGEEIAKHQIEYSTSASEAPDESQNTDQFRRRSSLMRHNQPIFTAEGVAISINDDIEIENNQASVGPTLRFPQPGWVECMPVHILANAVQCLIACLITLRKINQNPNLKTKYKVKCIGIANMRETTIVWSRKTGKPLSNGIVWTDTRTSEIVQHLERMTDDERKHELKEKTGLPLSTYFSAAKLRWLIDNDEIIKEEYEKGDGNLMFGTVDTWLIYHLTKERNFVTDISNASRTYFMDIESGDYDDELLDFWGIDPEKIRLPKIVSSSEHYGSFASPNFSHLGFHNKITPEAYEILRTINGVPICGCLGDQSASLVGQLAFESGSAKCTYGTGCFLLYNTGTKKLISQHGTLTTIGYWFPGLKGDDSKPHFALEGSIAVAGSIIQWLRDNLKLIENAKDIGPLASQVPNSGGVVFIPAFSGLYAPYWNGGARGTIFGMTQYTSSSHIARAALEGVCFQVRAILRAMASDAGASEDFLEKALSSQNEDKPLSSLAVDGGMSKADEVLQIQADILGPCVTVKRAAISECTALGAAIAAGLSFEDESERVWKDLDDVREKIGNGSGENNLFKAKLPDEDRRKFWKRWEKAVSRAKDWLDDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDT0</accession>
    <name>G3BDT0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase B18 subunit (CI-B18)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116423</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689586.1">
        <property type="nucleotide sequence ID" value="XM_006689523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDT0"/>
    <dbReference type="STRING" id="590646.G3BDT0"/>
    <dbReference type="GeneID" id="18248300"/>
    <dbReference type="KEGG" id="cten:18248300"/>
    <dbReference type="eggNOG" id="KOG3468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154847_3_0_1"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="83" mass="9774" checksum="574CC8FFBE88723E" modified="2011-11-16" version="1">MSVTKFPPLLSDDDLQKYKVPLKWRDRCAFYFALYQTCLIRQSANGSVDCGHDKHAWEECENLDLIRRKQELAQVKQARKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDU4</accession>
    <name>G3BDU4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_127572</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689596.1">
        <property type="nucleotide sequence ID" value="XM_006689533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDU4"/>
    <dbReference type="STRING" id="590646.G3BDU4"/>
    <dbReference type="GeneID" id="18249248"/>
    <dbReference type="KEGG" id="cten:18249248"/>
    <dbReference type="eggNOG" id="ENOG502QUEK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021797_0_0_1"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="693" mass="78885" checksum="278610F1689EB4C7" modified="2011-11-16" version="1">MEDPNVTKRKKTPPIAKKVNKTRRNAQATRTLRACDLCRKQKTRCFRVDENSNSCLRCSFLNKPCSFAITAGGFRLDGDPGISGASDTKKLDLIYSGVNEILRLIKSKGPGVVNDNDARLLLEAANTMKDTSIPPGNNGEEPDHEKMVTNPIDLENQSTFQSPTNSLEIAPFQIVNNQLKPEHVPKNIENLLSLSSFKQNPTPPGTGNIISLNLIPFNEVIHLMNDFRRNYGRWISFPSNLPTEILIERLTNKSPLLLTTCCVLSLRYSFNNINPGDINNLVRKRLVFNSLVKQLAKEMNLNLMRVNCFKGVSGDIELLQSLVILAIYSSSLTSIISSNCQALVKASGNNSSMNLKEFNLSLNDFNLDPWFLSGLGLNLFVSKVTFGSLIPKENIDLNASLNSPFTILYDEELDSNEYQILTLMRIYNHLVLVHIINCVFSGRMCIVDEIRLNNCNMTLGLPSSTNFDGRMVSEISILLITYNFIQLNTNMGIMSLEELNLNLGATIREIQAWYDQWEYLLQQPALQFVEVCYNFCNLLIYYTYNYQKHLILNNLRNLNATSDMFNEDNLKFIMNISSPHDKVKMFEYSNNIMTFINLINNDSYFAHLSDQLQFCFYFAGLFLLKFLYILRSEDNLRLVDLSDVNDMNSLGNIKTLISKFNNINNLEVNDSDIITKFKISLKHQFKKLFPEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE02</accession>
    <name>G3BE02_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_136908</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE02"/>
    <dbReference type="STRING" id="590646.G3BE02"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="eggNOG" id="KOG0572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_2_1_1"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="530" mass="59137" checksum="DB59FA32B0CF411A" modified="2011-11-16" version="1">MCGILGVVLSDQTANVAPELFEGAMFLQHRGQDAAGIVTCGSKGRFYQCKGNGMARDVFTPQRMNNLVGNMGITHLRYPTAGSSAGSEAQPFYVNSPYGITLSHNGNLVNSLELKKYLDETVHRHINTDSDSELLINYFASELDKFNKSRVNNQDLFSALKGTMEAIRGAYACVAMLAGYGIIGFRDPNGIRPLLFGERVNAVTGLKDYMLASESVVLKAHGYNKFRDVRPGEAVIIQKDPTKQPEFRQVVPPKIFAPDIFEYVYFARPDSILDGVSVYRSRIEMGNKLANKITQYLTREEIDVVIPVPDTSRTSALQCAVKLDVPFREGFVKNRYIGRTFIMPDQQERRSSVRRKLNAMESEFKGKSVLLVDDSIVRGTTSKEIVQMAREAGARKVYFASCSPPIRFNHIYGIDLADTKALVGFNRDEEEISKVIGADLVIYQELEDLVACCQSEEIKQFEIGVFTGNYITGVEDNYLQELEKIRAQNQRLKDRQGMGMSVDACIDASDMVDVKAEVDISIYNRGDYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE55</accession>
    <name>G3BE55_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116512</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE55"/>
    <dbReference type="STRING" id="590646.G3BE55"/>
    <dbReference type="GeneID" id="18248340"/>
    <dbReference type="KEGG" id="cten:18248340"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021695_0_0_1"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="448" mass="50360" checksum="7CA08CDFF4A5BDB8" modified="2011-11-16" version="1">MDEEFDVIVLGTGLTECILSGLLSVEGKKVLHIDKQDFYGGESASLNLSQVYSKFRPSGQKPELAGRDRDWCIDLIPKFLMSNGELTNILVHTDVTRYIEFKQIGGSYVYRNGRIAKVPANEMEAVRSSLMGIFEKRRMKGFLEFIAKYDEDDKSTHQGLDLDNNTMNEVYNYFRLENGTKDFIGHAMALWPNDDYLNEPAKPTYERIILYVQSVAKYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLGTPIDEILYDEKKNFAGVITKEGKAKAPIVIADPTYFPERVKKTGQKVIRAMCILDHPVANTSDLDSLQLIIPQNQVGRKHDIYVAVVSDVHCVVPKGYYLAIVSTIIETETPHVELEPAFKLLGSRVDTLMGIAELYEPQDDGTSSGIFISKSYDSTSHFESMTDDVKDLYFRVTGKPLVLKKRPSDQEEDDALNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEF5</accession>
    <name>G3BEF5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116600</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEF5"/>
    <dbReference type="HOGENOM" id="CLU_2721984_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="72" mass="8153" checksum="7FB81BF7CCB1210C" modified="2011-11-16" version="1">MPRTTSSSTSFCTDNNADGDKRPYTAVSGPYAMSSYGPTDGAHKYTWWELHHNGYVLKTPIFEWFLKAFSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BET9</accession>
    <name>G3BET9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116668</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690424.1">
        <property type="nucleotide sequence ID" value="XM_006690361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BET9"/>
    <dbReference type="STRING" id="590646.G3BET9"/>
    <dbReference type="GeneID" id="90981792"/>
    <dbReference type="KEGG" id="cten:90981792"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="303" mass="33596" checksum="978BE902C7EDB6F8" modified="2011-11-16" version="1">MSEQQKYALVTGASSGIGYAMAKVLSKKGYKVFGCSPKSDSFKMKPLADEFGVVPFDCDISKLEDIKALSKSVGKLTGGRLDILYNNGGIATGGAGIEMDEEEVNKVFQINVIGHINMTKHFVDYVIETQGAVVFTSSVASIIPLSWTSIYCATKAAINSYARVLHAELKPFDVKVYSVITGGVDTPIADHFDLTQVENSRYNVEGGYESVVKAKGMSRNKWTTEDPEVYAEGVARKVIGRSNSFNLYKGGMAYTLYLLTIWAPLWLMQWFISFHFKQNKVFRNLKKANKEKIKRKLTSKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEZ7</accession>
    <name>G3BEZ7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_110614</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEZ7"/>
    <dbReference type="STRING" id="590646.G3BEZ7"/>
    <dbReference type="GeneID" id="18246207"/>
    <dbReference type="KEGG" id="cten:18246207"/>
    <dbReference type="eggNOG" id="KOG0462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_1_1"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="59"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV59974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="657" mass="73656" checksum="58E7A1B93AFBB7F4" modified="2011-11-16" version="1">MVVRYLPRKLLNNGLRRSFYGSTLRYNAHIPSLIDKKISLDKENYIKQVQERIDKIPIENYRNFSVVAHVDHGKSTLSDRFLELTGVIQPGSNKQVLDKLDVERERGITVKAQTCTMFYTDPTTEQDYLLHLVDTPGHVDFRSEVSRSYASCGGALLLVDASQGVQAQTVANFFLAYSMGLKLIPVINKIDLDAADIPAAVQQVETTFELPSEECIPVSAKTGLNVEKILPRVISDIPSPGGTLDSPLRALLVDSWHDPYVGVVMLVFVVDGVVKKGMKLVSYHTDKKYEVKQTGIMYPDKLPTETLKAGQVGYIIPGMRNPRDAKIGDTFLQLGKHEGLEPLPGFEELKPMVFMGAFPADSSEFKVMNDHIENLVLNDRAVTLEKETSGALGLGWRLGFLGSLHASVFQERLDKEYGAKIILTAPTVPYKVNYRDGLEQIITNPAQFPTLAHTIEEISEPFVEAIMTIPEEYVGVVMSLCENNRGEQKDLEYLTTGQVLLKYELPLAQLVEDFFGKLKGSTKGYGTLDYEDAGYRKSDVVKMELCVNGEPQDALTQVMHRSQVTTKGRSSVDKFKKFLRSQLFEVAVQAKVNNKVIARETIKARRKDVTQKLHAADISRRKKLLERQKEGKKQMKSTGRIHIDHNTFQEFLRSSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF06</accession>
    <name>G3BF06_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_116007</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573</strain>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF06"/>
    <dbReference type="STRING" id="590646.G3BF06"/>
    <dbReference type="GeneID" id="18248120"/>
    <dbReference type="KEGG" id="cten:18248120"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="15">
        <location>
            <begin position="37"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV60971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="468" mass="52619" checksum="EE8186D14B5DAACE" modified="2011-11-16" version="1">MYVQLPFDDLKVNPNEKKRVAYFYDADVGNYAYGAGHPMKPHRIRMAHSLIMNYGLYKKMEIYRAKPATKQEMCQFHTDEYIDFLSRVTPDNLDLFAKEQIKFNVGDDCPVFDGLFEYCGISGGGSMEGAARLNRGKCDIAINYAGGLHHAKKSEASGFCYLNDIVLGIIELLRYHPRVLYVDIDVHHGDGVEEAFYTTDRVMTASFHKYGEFFPGTGELRDIGVGKGKHHAVNVPLRDGIDDATFKSIFEPVIGKIMEWYQPSAVVLQCGGDSLSGDKLGCFNLSMSGHANCVNYMKSFGVPLMVLGGGGYTMRNVARTWAFESGLLNNVILPSELPYNEYYEYYGPDYKLDVRPSNMYNANSPEFLNKILTNIIANLEHTQHAPSVQMNHVPRDAEDLGDEEEDTREAIDTKGGSQQARDEAIQPVNEFYDDEDKDVGERDVSVQPTKSELTAEEEKELEAMNQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF11</accession>
    <name>G3BF11_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bul1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_136492</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF11"/>
    <dbReference type="STRING" id="590646.G3BF11"/>
    <dbReference type="eggNOG" id="ENOG502QSAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022027_0_0_1"/>
    <dbReference type="OrthoDB" id="4007955at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022794">
        <property type="entry name" value="Bul1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007519">
        <property type="entry name" value="Bul1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04426">
        <property type="entry name" value="Bul1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04425">
        <property type="entry name" value="Bul1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bul1 N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="3">
        <location>
            <begin position="500"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="3">
        <location>
            <begin position="656"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="79403" checksum="D44F3EE05117236A" modified="2011-11-16" version="1">MFLDQEQSYNETEDFHFKEEDLKNVKELPLWNILPSYQMYSQSFFNQQPDPPHYDAPCSESSRYTPDTGAISLSVSAGPSTVSTQDLQSQAQSQSQSSVTTHSHSDSSPDPARVTFNDNEGHGWQSSVLDHVNKLNNMTETDNQFAKAIKIQTFYTADICKINEPPKLIDPSKFEYKQGDYINGYIKIDNISGLRIPFRMFYLLLQGSITVGHQRKTFLEMFDFHGSFLKYVYINRLVTEYTNSAVCPCFVDNDGSYMSFASEHLEPHTSYKRFFSFRIPSHLLDNECPSYTLSSHVRLPPSMGDVKDFGLVNSRIDYSVIATFIGKATSYQFNPTQENALVFNEHGDEYVILKDSKAPLRIVEETPPVQEGAAIHQDLLLSNLIKRIDERIQVGNKLAQILAHQKFQEISQVVDVLEEQIERQSSNKLQQLYVRTEREKSHKPKLITLEVNSSSMLLKKTALLTVSTPDVIYNLQYVQPKPIRGNGLPDLTLSVPFKMSCQSSSMPKLKSLNVDFACLTISSATPIPLEFNHKMLFRNSKPDSTYFNDHDNFQRNIVNFFKGEFERVKELNKKVNIDNLKFEKSLLDDIKTLALLKEKTVNLTVFGPTIVQHGSSTTSPAWNKVDSQWESEFELGLDFGNLSTKGTRVQNPFDTFTLVPDFQNCYGARLYYLKIQFEFSNHRVYLKVPVSIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF54</accession>
    <name>G3BF54_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gpi16 subunit, GPI transamidase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_100009</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF54"/>
    <dbReference type="STRING" id="590646.G3BF54"/>
    <dbReference type="GeneID" id="18245349"/>
    <dbReference type="KEGG" id="cten:18245349"/>
    <dbReference type="eggNOG" id="KOG2407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021459_2_1_1"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442832" evidence="2">
        <location>
            <begin position="18"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="598" mass="66566" checksum="C8DE7F968FE05E05" modified="2011-11-16" version="1">MIHQVIALIALICGIHANNNFYNESLSLTPLARNNLLANFNFEIKSLPKHLSYYNESNDKDSIADASHYTYFPRSIGPLLEKTNTRELHLRFAQGWWDSESWGSLPVNGSKSGGTGVEVWAVIEAPTSKEALKSWSKLAVSLSAFFCASLNFIDESITTFPINAFNPDTSSFSADPANKLFLLRAAMPSEPICTENLTPFIKLLPTRGKAGISSLLDGHRVFDSLWNSMSIDIQTECDDESEACNFKMDQSISVIVDVMRSLRKKENGPIPKPVEGDKLQCDKSRGYSVWQCFPLGLPTEITYSLRDVFGRPINGGPFSSQGVPVTVNFKAEGWDISFKDGMNKVVSLSENDSTYTILGDDEVNIDFKASDSSKTVGLQTAPLHASRSLTGYSQDKGGFRVVFENPGDSAISFVYFESLPWFIRLYLSTMKATSKGQTGTYQEVDSSEYVTLSHYQPAIDRKRPSHMELLVTVPAKETLTLHYEFDKSLLLYAEYPPDANHGFSVEPAVITVLDTNQKKVYELRTTSSLVVLPTPDFSMPYNVIILTGTVISLAFGSLYNLLIKDVITEEEFEKFAAQSKLRKLRAKIKSLKSFLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF79</accession>
    <name>G3BF79_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116718</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF79"/>
    <dbReference type="HOGENOM" id="CLU_2984435_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="58" mass="6654" checksum="3740C7E6EA94EDFD" modified="2011-11-16" version="1" fragment="single">MNDPRHSDQVRKKEFQLSKDELDGETQFTHDERVTPEKAPVGDSKESPSNLLPNIKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFD8</accession>
    <name>G3BFD8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_95499</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689247.1">
        <property type="nucleotide sequence ID" value="XM_006689184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFD8"/>
    <dbReference type="GeneID" id="18250508"/>
    <dbReference type="KEGG" id="cten:18250508"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="232" mass="24624" checksum="8A076C0093CAB977" modified="2011-11-16" version="1">MSTTYLIVGASRGIGFTYVKHLALNKSNLIIATARNENAAAKLQALGPNVKTILIDMQDPYSKFETSFKQLETLAPSGEYDVDAYDEVLSVNIGGAAKGYKAAYPFIFKGKGIKKIVFGSSLLGQVGYPIKGQAYAASKAGLNHLGHQIASTNAKSGDELVKNSATILLRPGVVNTDMTSASLDFKAKVPPSLFISQDESVTGTLSLVEKLTNADSGKLFNYKGAGFKFSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFP0</accession>
    <name>G3BFP0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADPH-dependent methylglyoxal reductase GRE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_116093</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689279.1">
        <property type="nucleotide sequence ID" value="XM_006689216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFP0"/>
    <dbReference type="STRING" id="590646.G3BFP0"/>
    <dbReference type="GeneID" id="18248164"/>
    <dbReference type="KEGG" id="cten:18248164"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="334" mass="36763" checksum="985E376564F2DA32" modified="2011-11-16" version="1">MSTVVFVSGFTSYIALHIVKKLLAKNYKVVGSGRSHEKCQQYTDIINNPLFSFVVVPELSADNAFDDVFQQHQDIKFVVHVASPLVPIIEDPEKEALIPAINGTTSVLKAAHKYGPHVKRVVITSSYVAHCAPSDHYGGSDLVITEESWSSITYEQSLQPNIAYWGSKKFAEKAAWDFLENEKPQFSLATYAPTLVFGPQAYDEVAKQGPVSTLGIISSVLKKDYSAEKMLFGDFSDVRDVSEGHIRAFELESAAGHRFLLGNGRVSVGRIVEIVRKHFPELELPATEVIPDDKLGVASTNCEETLTVLGQKDLISLEQGVVDSVKQMLDVGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFP7</accession>
    <name>G3BFP7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_131945</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFP7"/>
    <dbReference type="STRING" id="590646.G3BFP7"/>
    <dbReference type="GeneID" id="18249576"/>
    <dbReference type="KEGG" id="cten:18249576"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003782_1_0_1"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="744" mass="86468" checksum="FA8E612186ED0C6F" modified="2011-11-16" version="1">MSHFNMELDSHDPDSDNDDFALPQTYPMHHEEDPMEESLSKSFSSAHFSTAEDRFIKDHDLKLKAFEALNESKSPHGSSKRRPSIIDLPNTSRYFHPAPSNAVHNNAHDPHAETSSNALPEEYPSEELIGLFKNVKVSLDLRHKYQSISLQLSEMDNPKNKDEWSVYPPPPKPTYKSKNRFNQLPSVDSDVEEEFDLSKCVIPEPTDAYDFRTNNEDVFEIYDKLSNENIIRVPGIAEYYGDLKTIAKIASDGPTKSFSFKRLEYLEAKWNLYYLLNEFEESKQSKKNPHRDFYNVRKVDTHIHHSACMNQKHLLRFIKYKLKTVPHEEVIFRDGKVLTLEEVFKSLNLTGYDLSIDTLDMHAHTDSFHRFDKFNLKYNPIGESRLREIFLKTDNYINGKYLAEITKQVFEDLESSKYQMTELRISIYGRSYDEWDRLAAWVIDNKLVSHNVRWLIQVPRLYDIYKKNGNVMNFQDILINLFEPLIKVSLNPKCNPKLHVFLERVVGFDSVDDESKQESPHRKYAPAESWDFSNNPPYSYYLYYLFANLSSLNHLRAKLGFNTFLLRPHSGEAGDPEHLISAFLTSHSISHGILLRKLPFIQYLYFLDQIGLAMSPLSNNALFLTYDKNPFFNFFKKGLNVSLSTDDPLQFSYTKEPLIEEYSVAAQIYKLSAVDMCELARNSVLQSGWEASIKKHWLGKKYMAGGTEGNNIEKTNVPNIRVNYRERTLQSELALVEYYTSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFQ8</accession>
    <name>G3BFQ8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_132405</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFQ8"/>
    <dbReference type="STRING" id="590646.G3BFQ8"/>
    <dbReference type="GeneID" id="18249618"/>
    <dbReference type="KEGG" id="cten:18249618"/>
    <dbReference type="eggNOG" id="KOG4836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="263" mass="29726" checksum="9E47C2575C6C3419" modified="2011-11-16" version="1">MSAVRLLQLNAKAYTSLVIHRSALSTMRPMVSNFYHFRTRFRTPQITSSIIVNQPFKHSRSYSTKTSPPPPPPPSPSKDKNAKGKVFLNRISRAFTFSLSTVIVIGASGVALLVVYLILSELFLPSGDTKTFNKAVKLVEKNEQARALMKLTSGERIRAYGESVSGKWVRNRPVQSVRMRDQDGVDRLVMKFHVESDACMHGTVSLEQIDQSFWSSEFAYIALDVPKKNRIYIIEPKFQAKNYVPKITRQSGFLGLKWGPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFU2</accession>
    <name>G3BFU2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_116804</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFU2"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773852_0_0_1"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="358" mass="41514" checksum="233FC6A90880069A" modified="2011-11-16" version="1">MEAPPTEHSITPVAEPLPESISVALDEPDIKDDDEDEPKKRNNKADSDDLSCKWTDCPESQHTNLPSLVRHLNNQHLNYTNSLTVNTPTKYSCLWEGCARYGVEQPSRFALISHCRTHTGEKPYFCPIPECEKHFTRSDALAKHVKGVHDLHILRDAVTLNRDRVKKGRMEANFLNQDKVTELEFLSMIEDDYELRVPWWFSNDFLNIVSDSSDEFKTLYRIPLTSKQYRIAMKRYQSYYHEQFEDNDTKLPPQLKNAIDAFTEMQPEDESEDTVIDLGELQKLHQKLSNQLSTSQRVNKIATKQLTHLVDEKRKLWYIKEVLLDANAKLSIPIRSSDKDAGQPDKYDDELYDSIKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW19</accession>
    <name>G3AW19_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mating factor alpha precursor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_91594</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW19"/>
    <dbReference type="GeneID" id="18250093"/>
    <dbReference type="KEGG" id="cten:18250093"/>
    <dbReference type="eggNOG" id="ENOG502S0T3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1786592_0_0_1"/>
    <dbReference type="OrthoDB" id="10617785at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007618">
        <property type="term" value="P:mating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008675">
        <property type="entry name" value="Mating_factor_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05436">
        <property type="entry name" value="MF_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442603" description="Mating factor alpha precursor N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Mating factor alpha precursor N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="145" mass="16543" checksum="502159913480DCA7" modified="2011-11-16" version="1">MRLSTILTLALTSKFVFSAPVEKVKREDGLDVPDEAIIAVYPIDEYKQPFYAEADGQNYVVILNTTALGEADLAKRDADAFSWNYRLKWQPISKRDADADADADAFSWNYRLKWQPISKRDADADADADADAFSWNYRLKWQPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW44</accession>
    <name>G3AW44_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_91614</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW44"/>
    <dbReference type="STRING" id="590646.G3AW44"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="12">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="485"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV66448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="602" mass="68763" checksum="5BF0D1C0B48C029F" modified="2011-11-16" version="1">MSDIKVISSQLAKLGLENPTAVEGSYPNHNVLDLLRNYITDELHQLSSVDKRIIFESLDIPSTLDKGDLIIPVPRLRLKGINPKDKAAEWASAFNKGKYLKEIKAEGPFLQFFIDNSLLYKLLIKDTLERKSSYGSLPVGLGKKIIVEFSSPNIAKPFHAGHLRSTIIGGFIANLYETFGWNVTRINYLGDWGKQFGLLAVGFDKYGSQEALDNDPINHLFDVYVKINKDVVEEGEDSEINNKAREFFRKLEDDDQDAISLWKKFRELSIKKYIETYNRLNIKFDVYSGESQVSKDIIKKVSDIFEERGLLYEDKGAKLIDLTKYNKKLGKCLIQKSDGTSIYLTRDVGEAIKRYETYKFDKMIYVIACQQDLHVAQFFEILKQMGFSWSKDLLHVNFGMVLGMSTRKGTVVFLDNILEETKEKMHEVMKKNEGKYAQIENPDEIADLVGISAVMVQDFQSKRINNYEFKWDRMTSFEGDTGPYLQYAHSRLMSVQRKSGFEESELLNANYDLLTEECATNLIRVIAQYPETLNKALKTHEASAVVTYLFNLSHIVSTCYDILWVAGQEKELAVARLALYASARQVLNNGMKLLGLTPVERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWC0</accession>
    <name>G3AWC0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_117455</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWC0"/>
    <dbReference type="STRING" id="590646.G3AWC0"/>
    <dbReference type="GeneID" id="18248573"/>
    <dbReference type="KEGG" id="cten:18248573"/>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029282_2_1_1"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="8">
        <location>
            <begin position="121"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="329" mass="37228" checksum="46C331466683F2DC" modified="2011-11-16" version="1">MFRSHILKTKIPPSPQYWGRRYFSIEPQTIVMALGETLQAVHATSGLPWWAVIPLSTFALRTVWTLPLSILQRKRLQKQSEYKAIISGTTPVLKLNLGQRAQETRNQLAAPSSSDSERAVQLQSPLANIKYEEILLLSAKETRKRQKALFKKHKIQLWKNFVLPVFQVPLWISLSLTMRNLCGWLSWDSLANQPLDPGLYTEGLLWFSDLTSYDHYHLTPVILGVISLCNVEWSFKTFELSRLASRPTLRPTLADAFANLSRMGVVFMMAIAMNAPVGLTLFWISSQTFSLAQNVVLDMAFPVAFTPRTRVAPSVASTDSTPIVNRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWU6</accession>
    <name>G3AWU6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112334</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWU6"/>
    <dbReference type="GeneID" id="18246474"/>
    <dbReference type="KEGG" id="cten:18246474"/>
    <dbReference type="eggNOG" id="ENOG502SY3N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185438_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442670" evidence="1">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="82" mass="8114" checksum="3EDEA685A080609A" modified="2011-11-16" version="1">MQFTTVALLFTAVVSATTVTETDLSSTLVTITSCGTEVTDCPAATSSAANTTVANVSTWEGAANRQYAVGAAALAAGALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWV7</accession>
    <name>G3AWV7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_117734</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWV7"/>
    <dbReference type="GeneID" id="18248592"/>
    <dbReference type="KEGG" id="cten:18248592"/>
    <dbReference type="eggNOG" id="ENOG502RZ1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085105_0_0_1"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="293" mass="33482" checksum="EDFA2413E52F5B0A" modified="2011-11-16" version="1">MFGLQKYIRPFSMHKCVCGPRSRMPSALEWYYPTTSLVWKKHASLAPSSLSQVKNCEQYLQHCHTNNVSFTSTVFRGTLYEYASKAFLEDKLKCFDLVRKGGAFDNGIDLVGKWDLSHFFKLNETDIKAAKVLRSRAKVIPIITNSKELHELKNTKSTKKNISIKHDINILVQCKNHRTKIKASILRELVGIYSQYIKNDDDKNSTFMVLMSPSPLSKQAHSIIDQTSIPLIHIILSPLELSSHDTSIDNSVIDSWDGGVVQSIYLNSYSKILLKYLNIELEFQKLKSYIMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWX0</accession>
    <name>G3AWX0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartate protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_112349</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWX0"/>
    <dbReference type="MEROPS" id="A01.018"/>
    <dbReference type="GeneID" id="18246484"/>
    <dbReference type="KEGG" id="cten:18246484"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_3_4_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442741" description="Aspartate protease" evidence="14">
        <location>
            <begin position="25"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="111"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="142"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV66639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="425" mass="45614" checksum="BFD4CB68837991F7" modified="2011-11-16" version="1">MHFSLPILTSIATGLLALTSPVAGAVHSAKISKIPTDTTLSAASYKEYVNSLQHKYVNTFNSAHGNPVAASAQFPGSKAQIPFIESKMTEDGEIAINGHDTPLSNYANAQYFTEIEVGTPGQPFKVILDTGSSNLWIPSQDCSSLACYLHSKYDHDASSTYKANGSEFAIQYGSGAMEGYVSTDALRIGDLLIKNQDFAEATSEPGLAFAFGKFDGILGLAYDTISVNKIVPPVYNAINQGLLDEKSFAFYLGDTNKDEEDGGVATFGGYDESKFTGKITWLPVRRKAYWEVSLEGLGLGDEFAELKSTGAAIDTGTSLITLPSSLAEIINAKIGAVKSWSGQYTVECDARANLPDLTFNLNGYNFTLSAYEYTLEISGSCISAITPMDFPKPIGDMAIIGDAFLRKYYSIYDLKKDAVGLATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWX5</accession>
    <name>G3AWX5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_112353</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWX5"/>
    <dbReference type="STRING" id="590646.G3AWX5"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029658_0_1_1"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="271" mass="30357" checksum="1AA1EF3FE79A895B" modified="2011-11-16" version="1">MSYFIPEEQDHTGSEAESQSDDQLLMHTLHTLPANCKKFWRRRYQLFSLYDEGIFMTSELWFSVTPENIAAFTAHAVHELLPDAHDVLDICCGGGGNTIQFANVFPRVGAVDIKQVNVDCTLHNAGIYGVADNIWTATGDWNQLSQSRDWIPTDIRDKPQPFDFIFCSPPWGGTSYSREENSFRLNEMVPLRFDVLCESMAAISANFGLFLPRSSHLGDISKTSTKLFGVSAKTRIINLVTEDHIRGLLVLFGPDVMGPLSCIDNVAPMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWX8</accession>
    <name>G3AWX8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112354</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWX8"/>
    <dbReference type="STRING" id="590646.G3AWX8"/>
    <dbReference type="GeneID" id="18246488"/>
    <dbReference type="KEGG" id="cten:18246488"/>
    <dbReference type="eggNOG" id="KOG2154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015945_1_0_1"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="4">
        <location>
            <begin position="330"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="552" mass="64415" checksum="E6C4788E0AC4C642" modified="2011-11-16" version="1">MAPKRKSNSKVAKPAPKKSKSDTSLWTLDHIKQVSQDVIEKSSYNDIVKLIDQYSYIKSALIQTEDSSVESIGRQLTINMYQIFQHLFQAGLLRPSKKFDDKKMILVKWLVDKYDRFKKIMYQFLSTSLSFKSSLQLDILDVSLNVLRLENQYLKSSKDDLYFPTSTYKAIVKSLVCSEVGTVLSDNTIDDFIMLEFQEKLHKYYDLQFYFFQCLNELVEQDEIPDQNRLFSIFYTLVKIPLAFEENPKELRAIKTFISKPPTTIFKPSHFKKAFQTLVISILSFKLTSSQYKCILLILNKRILPYLAQPSRLMDFLTDSYDTSDLIIQILALNSLYELMKQYNLEYPDFYTKLYSLLTPELLFNRYRSRFFRLSDLFLSSTHLSSNLVASFIKKLARLSITGPAPGVVIIIPFIYNLFKRHPSCMIMIQNPSQDPDTYEDPYDNNELDPLKTNAINSSLWELEALMNHYHPNISTLAKIFTEPFRKPNYNLEDFLDWSFKSLIESEINRKYRSMAALEFDSFDQLFDHVTGTSEGSEPESKTTVYLEGWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXE9</accession>
    <name>G3AXE9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial distribution and morphology protein 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_91521</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXE9"/>
    <dbReference type="eggNOG" id="ENOG502QQU5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016236_3_0_1"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="74257" checksum="CD22BFBAFAB526CB" modified="2011-11-16" version="1">MYSIRTSPGLLSTSFKSHRHIFGSGGIFIHRSIQPAILRSQKRSTQSDVFQRSFHATYRALNIQPPKPQPKSDFASTTKEKFQLTKSKLLAQASGPLSRLLIHIKWPLKRNNKPFSIDDMSAMFSWVVMGNVLWILLGTTTFGLTLLYSLHTFDSLVNKILAYFNHDNDDNNDNNDQNKKGGKASGPQKDDSILGYLTSSILSHGLGIKIEFEKKGILPEFNDGKLIFKNIRLKSLDNEHSNVSFSCDVQSLSLSLSFGKWSDGHGLIKDLEIFGLNGKVLKKYELHSSSVDTASPFVFRRLHDSIHFQFDMSDQKDVLASPKKPRVDPNYELNSVKIHDSYFEVFDSKTQDEPLKFSIFNCELPKLTGKSLLVDFFNASNVTGSINGSMFTIHKKQDYNARPSENTIRFKLDGIDMGGLAHSNPQSKFNWILNGKAEIVADIRFPSPGVEENSLFKIEYKRFAEIINRVFYDLGTINNKNDEPITKRDDSHDDAKLMKGALQAIYQTFNMDQEDNRQIVSSEFNSEYVFIDAKVKFYNLQATLPKELPLASTGNVPFLNLHDLRSLVSYINKIDTENKPPITMKTMVIEKLEDLYNVEHLTQTRVFDVIVSEIYEEFLKMVKMDEERIISEKSSLWSHSVASQLLLLGLGAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXK5</accession>
    <name>G3AXK5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRTase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112136</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXK5"/>
    <dbReference type="STRING" id="590646.G3AXK5"/>
    <dbReference type="GeneID" id="18246370"/>
    <dbReference type="KEGG" id="cten:18246370"/>
    <dbReference type="eggNOG" id="ENOG502QRN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="214" mass="24171" checksum="2C6711E38D5DC4C9" modified="2011-11-16" version="1">MSAEDEKMYISYNNVHQLCQEIADKIKKFNPDLIIAIGGGGFIPARMLRSFLKEPGQPNVRIMAIILSLYEEIDTYGDDAENPGTKVVRTQWIDYNQSKINLVGKKVLIIDEVDDTRTTLHYAVSELKKDVVEQAKAVGADPNDTTFGIFVLHDKQKTKKADLPDEIMKTGNYFAARTVPDGWIAYPWESVDIVYHTKMAIKQGNDVFIPSSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY82</accession>
    <name>G3AY82_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reduct</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_118482</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY82"/>
    <dbReference type="STRING" id="590646.G3AY82"/>
    <dbReference type="GeneID" id="18248645"/>
    <dbReference type="KEGG" id="cten:18248645"/>
    <dbReference type="eggNOG" id="KOG0564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_2_2_1"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="309"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="614" mass="69973" checksum="BD729D0E4C8C06D7" modified="2011-11-16" version="1">MRISEKLNQAYSSSNPPPATFSFEFFVPKTSQGVQNLYDRMDRMYELNPIFIDITWNAGGRSSSLTNEMVYTAQSALGLETCMHLTCTNMSVSLIDEALERAKKSGCQNILALRGDPPLDGTESTGDFKYAKDLILYIRKNYGNYFNIGVAAYPEGHPEESDLDLTVKYLKDKCDAGADFIITQMFYDTDNFIEWCSKVRKIGVDIPIIPGIMPISTYAAFMRRAKWSEIKVPKHFLDVLEPIKDDDFLVREKGTELVSQMCTKLLESGYVKHLHFYTMNLERSTIMCLENLGLIDQVKSHDTIGGAILPWRKSLNPSRQKETIRPIFWQNRKHSYISRTSTWDEFPNGRWGDSSSPAFGDIDLNAADLLRQSPKRAFELWGHPQSLKEFADLTISYLRGQLKSMPWSDGSISEDTSVIAEDLVKLNQNGFITINSQPPLNATRSNDKVFGWGPKNGYVFQKQYLEFFCHKSVISKLLDQVDIFNKSSGDNSRVLTYYVVDKTGELITNTNDEDINAVTWGVFPGEEIVQPTIVERNSFLAWKDEAYSLITEWVRIFESNLAKDFLKGKEAQVQTSIEFFKSFETDFVLCNIVNNNFTDDAKELFGVFEGLQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYM1</accession>
    <name>G3AYM1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_101635</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYM1"/>
    <dbReference type="GeneID" id="18245489"/>
    <dbReference type="KEGG" id="cten:18245489"/>
    <dbReference type="eggNOG" id="ENOG502QPR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_0_3_1"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="30"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="540" mass="62034" checksum="8F64F4D65241F6D2" modified="2011-11-16" version="1">MSARNASKAIYKGHHLDLGCFSRPHNKPLTLILCLDGTQNEFGPLPFSNCLKIFSMLDKDNPSQICYYQPGVGAQFDLYDGVYGPSKVFTSVINYLRRQIDAIWAVSFSAHVKAAYVFLMRFYREGDTICLIGFSRGSFAARILVGMLESVGLLNRGHEEMVSRAWSIYSSWENAGQPSHLENGSLIAEFKRTFCRSTIRVHFMGLFDCVNSVGLINDRMFPYSSMSAIVDHVRHAISLDERRGKFKQVMFKSYSYLPHLTDVEQGEYSCEGSSETNSLLPKEGRYLSFMRSLFARFFGDSSMKNPKNDHQSQDTKEVVFPGNHGDVGGGWLDPDTDHMLSNIPLRWMLSYAIKYGISFKPEAIEEFNTSFSATSSLLAHDHDMLKLHTSVTPRYIRELPDRPIQGNNGFGTSSAFQMIMWWAVELFPIGIKIEDEWGQWRNWYVPNLGRPRKFPSDIHLHWSVFYRMHFFEDYSPKNLPPDLKTKFLESIKPFEGNIESQQLQELLSDFNVEKIKGTWENKIWHQIPDELCQTLNNNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYN3</accession>
    <name>G3AYN3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101853</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYN3"/>
    <dbReference type="STRING" id="590646.G3AYN3"/>
    <dbReference type="GeneID" id="18245506"/>
    <dbReference type="KEGG" id="cten:18245506"/>
    <dbReference type="eggNOG" id="KOG2599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046496_1_0_1"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="70"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="314" mass="35605" checksum="F4AF2051973D538F" modified="2011-11-16" version="1">MSTVLTVSSHVVHGYVGNKAIIFPLQCTHWEVDNINTVNFSNHTGYGKFKGDSITPQLLTRLLDNVQPFKFLITGYIPNKTLIETLSKYLSQAREPPHSKLPFVFLMDPILGDEDQLYVDPSCVNSFKDLLYQNYIDIITPNQFELELLTDVKIKTVPNLVSALNKLKVQNIQFVIVTSCRFSPEEKFLYCVISTSSNSDIKYFKVPLIESYFTGVGDLFTGLLINKLYANYYSKANCELLDDLECLSISVNQVLTTMTKILKRTNEIGLRSGRTAEMGSLNIGPYELDLINSRDLFACKDCEFEEHTLINSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYR3</accession>
    <name>G3AYR3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_92253</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYR3"/>
    <dbReference type="GeneID" id="18250176"/>
    <dbReference type="KEGG" id="cten:18250176"/>
    <dbReference type="eggNOG" id="ENOG502QT0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410587_0_0_1"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="684" mass="78535" checksum="5DBA0982CB7E8970" modified="2011-11-16" version="1">MGKARPVKRRTRSGCLTCRDRHMKCDEQLPVCQNCIKSSRKCYRGVRLNFIQYSFYDPNDDVQLGKSFRILDQSVTIAKLYDGKRHYRPYLGLHSKEDLKESDEIFKMECENGTGISLLDGEFSGEFISGNRSLPNGSVPNGGRSKSAGDTRAALVSNSPQIEGVKLDDDLGVLDEKVNKGPLNKYRLSSRPHSRLSNEDMSGGFTAPRPQTSIDSPFFSEDLMSTLEMPNMSSTFSIQNFLVKPQHEVELPNLSSSKIIFDNPNFEFDVHKFIRLMDFERYYWLLDLFNELNIWKSLVPSYCVSLVNNHMENTQVVGNTFLMECLLNCSLENVGQWDHSGNIYRTQLKLFHFSRKLPVSMDNVKLFEILFISIVLILLKLLNRIVFQNDLNDIHVVFNNQARIFNKSVYKLFHTSSTKQRKLRSAVLVSCLQSTSILKFLINKNIESHQYSNNDTPNDDVLESKEDNNRDNDTNESFDLDGDANGALQAAQGLKKEPGLSPTGLEYSSPSSIDSAAWEEDMEEDIEYNHEEYATIKKLNYFEVQNLFSDFFDFDFPQIDDQFTSNASKLRRIFWYLMRLDYSSKFPAFKTFDIKNNFEIPQYPAFHSNIIFPNDQLTLIVLLSKYLLLALEQGDTNPLKLQAQENGDTNLTASLNSTFEVINNSMITDSQKRVWIGHFGWMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZU8</accession>
    <name>G3AZU8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA protein C-terminal winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_102934</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZU8"/>
    <dbReference type="GeneID" id="18245593"/>
    <dbReference type="KEGG" id="cten:18245593"/>
    <dbReference type="eggNOG" id="ENOG502QTW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021105_1_2_1"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="3">
        <location>
            <begin position="334"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="561" mass="64973" checksum="68DA0769EE5E60BB" modified="2011-11-16" version="1">MGTFLIKCLEAIGVTFSSIFILGVAGFLYHRFYNIHVLDKMDMAFDKGDPTLQLSMHKRNSTLIDDQDGEDRESDDYWVERPQQKLLNDIISGRIVGRYFLLVGEKGTGKTSLLLESMEEVNGYNVAIFDAHADPEIFRIRLGRALNYTFNEDYIGSLFSIKGPRDTTALLDIERGFNKLEQLALRRVTTNHNRPLILIINNTHLIKEDEEGGKLLELLQQKAEALSGSGLVTIIFNSDDYWVYEKLKKLGTRLELINVRDFNRMETVKALKFIRQKHFPTHRFPDQQLTDDACHKVYDLIGGRPQHISQVARHQNIFSACHEIIDREKTWFLNQCGILGMAMDDDVMEHGKFSTAAMLLMREFVEMDRKRKNTLILQNSPEQKDQYKSHVLPELPLWRARQIMTRPDYIQEYDNLNIFTIDSESRVRADSIPMMRGFHEIASQPNFDELLDETIERVADIESLGRTREIVIKDLGLGSKYRVVAHNDTKSYEVSLDKSGRQKLKDGDEQDEDDQTSDYFLEDLQTKESRRWWKKRMPSTKRATASDGTEYDIDLNRSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZW9</accession>
    <name>G3AZW9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="19">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTEDRAFT_102671</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="17">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 19">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion inner membrane</location>
            <topology evidence="1 19">Peripheral membrane protein</topology>
            <orientation evidence="1 19">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="19"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZW9"/>
    <dbReference type="STRING" id="590646.G3AZW9"/>
    <dbReference type="GeneID" id="18245569"/>
    <dbReference type="KEGG" id="cten:18245569"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000026">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 17 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 17 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 19" id="KW-0813">Transport</keyword>
    <keyword evidence="5 19" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="56"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="506"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="450"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="18">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV65261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="641" mass="70520" checksum="DF3C18695BB8AC47" modified="2011-11-16" version="1">MLSLRNVLGRPSSSTVRMFSQSAVASQTIGSNIKGTDFNAAKYMGQKYHVIDHEYDCVVVGAGGAGLRAAFGLAEAGFKTACISKLFPTRSHTVAAQGGINAALGNMHKDDWHWHMYDTVKGSDWLGDQDAIHYMTKEAPQSIYELENYGVPFSRNEEGRIYQRAFGGQAKEYGKGGQAYRTCAVADRTGHALLHSLYGQSLRHDTHFFIEFFATDLLMQDGECVGVMAYNQEDGTLHRFRAHKTVMATGGYGRAYFSCTSAHTCTGDGYAMVSRAGLPLEDLEFVQFHPSGIYGSGCLITEGARGEGGFLVNSEGERFMERYAPSAKDLASRDVVSRAITMEINEGRGVGAHKDHMYLQLSHIPASVLKERLPGISETAHIFAGVDVTKEPIPILPTVHYNMGGIPTKWTGEALRKNEKGEDEVVPGLFACGEVACASVHGANRLGANSLLDLVVFGRAVAHTITDQLTPGTPLKPAPKDIGMFSIENLDKMRNANGTKSTAEIRLDMQKTMQKGCAVFRMQDTLDTCVEHIKEVDKSFAQVKTSDRSMIWNSDLVETLELQNLLTCATQTAHSAAARKESRGAHARDDYQSRDDENWRKHTLSYQTNWGDEVKLDYRDVIRTTLDENDCKPVPPAVRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZY3</accession>
    <name>G3AZY3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113008</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZY3"/>
    <dbReference type="STRING" id="590646.G3AZY3"/>
    <dbReference type="GeneID" id="18246779"/>
    <dbReference type="KEGG" id="cten:18246779"/>
    <dbReference type="eggNOG" id="KOG3354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077168_5_0_1"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="184" mass="20623" checksum="C5B8E662E76559D2" modified="2011-11-16" version="1">MTGTIIVVGGPAGTGKTTAASKLSTYFDCPYVEGDALHPQANIIKMSKGIPLTDDDRWDWLITLTEQTAVKCKEDPHNIAIVTCSMLKKSYRQLIKDHGKSFNFVFCFLYASFDELVNRVENRKNHYMKSDMVKSQYEIMEVPEGDELVENGGDCLAINTTGKSLDDIFQEICNTIRVGRVIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZZ8</accession>
    <name>G3AZZ8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF396-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_102824</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZZ8"/>
    <dbReference type="GeneID" id="18245587"/>
    <dbReference type="KEGG" id="cten:18245587"/>
    <dbReference type="eggNOG" id="KOG4136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058268_0_0_1"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24611" checksum="7B572468C36A977C" modified="2011-11-16" version="1">MFLQLISYLGVGFGFLFLVLAIASALYYLSELVEEHSEPTKRILKRLIYIITGVLVLLYLFDGFPFLLTVFSMFSYFVYLQNLHKFPYVQLTSPIFLASCGLVVANHFFWFNHFHNPYIPPLEERLKPEYVPPHIPSFTEICSFFGLCVWLVPFALFVSLSANDNLLPHHMEVDPSGKKKNNGLAKVVVANIRDNVYSASRALGYELDPHHGQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3B004</accession>
    <name>G3B004_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113021</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B004"/>
    <dbReference type="GeneID" id="18246788"/>
    <dbReference type="KEGG" id="cten:18246788"/>
    <dbReference type="HOGENOM" id="CLU_1578317_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="169" mass="19727" checksum="AEF96D34A03C582E" modified="2011-11-16" version="1">MLLHTLVLLEGKLQYLNLQFEVMNFDHTKHLYSAILSHQWRLKSLILYDKSNEFFNEKQMVKHLKAQFSQFEKTTFYLQLFYKTYPISLEPYKCVSGISSIYKTFFSENQDALSVYLADYLKSVGLKSPPTSLEQFVVNNVPLVVLNGSWTFMDAAKTPILFPDSKYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B035</accession>
    <name>G3B035_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113032</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685185.1">
        <property type="nucleotide sequence ID" value="XM_006685122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B035"/>
    <dbReference type="STRING" id="590646.G3B035"/>
    <dbReference type="GeneID" id="18246794"/>
    <dbReference type="KEGG" id="cten:18246794"/>
    <dbReference type="eggNOG" id="KOG4168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092529_3_0_1"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="139" mass="16283" checksum="AD4C49D4FA6D2526" modified="2011-11-16" version="1">MKVLIERDKFLSDYEVLEHLKATQNPKDKKKSKHGGLELEIVSKEIISFLEDRACSQIESPDKFKQLMVFLNQYDLVKIEKLQIMNSLPRSMVHVHAVIEECDQRLNEDSVNSLIDKINELFPLPENDEEDQQQEQQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0N5</accession>
    <name>G3B0N5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_113196</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0N5"/>
    <dbReference type="STRING" id="590646.G3B0N5"/>
    <dbReference type="GeneID" id="18246851"/>
    <dbReference type="KEGG" id="cten:18246851"/>
    <dbReference type="eggNOG" id="ENOG502QRIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="64"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="467" mass="52102" checksum="737F205AF95C7CA5" modified="2011-11-16" version="1">MTTHTNAHYRDITREQCKQNPYAALVPGQTIVEIPKFELECGETLHNFPVAYKTWGRLNHNKDNVIVVCHALTGSSDVQDWWGPLLGTGKTFDPSRFFIICVNFLGSPYGSCSPLSIDRATGKPYGPSFPLVTVKDDLGIQKLILDSLGVKSIAAVIGGSMGGMMALEYSSTYKGSGYVRAIVAIATSARASAWCISWNEAQRQCIFSDPEYNDGYYYESPNGVKPDSGLSAARMAALLTYRSRNSFETRFGRKLPGVKNTAEAERIYPTTKDEENWLLHNEGARSVRAGSPNHSLNNSGKLQTYFTAQSYLRYQGSKFVNRFDANCYISITRKVDTHDIARGQVPLDDNNDDPLPEYLATLKLPHLVIGIQSDGLFTFGEQQMLDQYLPNCSLKKLNSPEGHDAFLLDFEIVNSYCQEFLKKQLPELYDDNSGKVVLFENWKDFVQSVDNGGNSVFGEAEKDITNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0S4</accession>
    <name>G3B0S4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_129985</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0S4"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="424" mass="48127" checksum="1098B6F635465554" modified="2011-11-16" version="1">MVVEQSIKKIAIIGGGPSGMASVKTLNTEKCDFDIDLYDSRANLGGIWNYFPTKSQYNDDHELVANDEYNHSPLYANLETNILYKSMEFTNFHFPEESVDFPFRTEVLDYLTKYSKTLGPYNKYLNTRVTGVEKNGDSWELVSKNVVSGEVTTRLYDAVVVANGHFEVPRIPEVDGLDEWKKRDPKSITHAKFFDTPSRYKDKTVLVVGGIASGSDIAIQSSATAKKVYVSCDETTILSNINNPFIEIIPRIESYDVNTRSVSFGGEKVSDIDEVIFCTGYLYDVPFLKLDICKKRYIQDLYRQMFYVQDPSLTFVGLGKDVSPFPFAEAQSSIIARYYSGRLKLPTSDEMKSVADEELKTKGDRLHGLKFPKEGEYINGLFQLLEDRDLLDGVERKKKVPEVKLKRVINNNQRILDERGVFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3B158</accession>
    <name>G3B158_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_121017</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B158"/>
    <dbReference type="eggNOG" id="KOG0298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001592_2_0_1"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1319"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1422"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1583"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1583"/>
            <end position="1604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1668" mass="191233" checksum="04BFC3978601023D" modified="2011-11-16" version="1">MIPSTGTYSFQTKHISLSIPRDSHFLSIKNHKVFKMKEESLLTFNLEEHQEEVLYLRQELLLLQNANSKSNYTIQTESPSVKFSINLKDKTLEAEICYKVFYGPYVNELVPLNVSLKISRYLNWNVKPLSSADTSTFPDPSTPVTAHLFYDSMSEHAKTLPDIASQFELPELETNLLRFQCRTVNWMLTKESVQYNWSSNRCENKHLISYELTEKIQSFFDHPDGASPEEMESIDTEVGQALGGLCFGWASVMFREENFWYNKYTSNLVDRVSMYRFILNYHSSNDTPIILPAQGLLAEEMGLGKTVEVTALSLLNPRPTDQIDDTIHIQLTNFGDHKPVLQSKTTLIIAPDSILKQWVEEILRLAPSLAVTIYKGLNKYPKLNNNPRLIADYLKMFDIVFTTYSTISKELDYALYSSRNKNTRASSRKRSSRTHEADSSNEDVSETEEVQDPKQEAGVYDQDALLKDYRSLFQLSMSSKKPKIANMKTDEDQAQTDYEKILEDEIQLALKHNKLPDLYRNSSYESPLMLLQFWRVVLDEVQMVSSKISRPFQCASLIPRFHSWAVSGTPIKKNLNDLHSVLAFLRYMPFCGKIGKSSWDLLTNIEVNTNEDFIYLWKSIGLRHTKAMVHDDIKLPPQNRVLMSIPFNVVEQENYNQVLEQCLASICLDVNGTPVMDSWEPTPTIVSYMKSWLVRLRQICCNPQVGQLNLNTRRYRTRYYLYNNNSNSKFVQTVQVLKTLENVLDDMLESAAAEIIKTERNLMGAYTDLAFLCELTLHPKAARRYFNFVCLSTQGILARTKVMLVKAKERRNQLTKVADAVTNVDDEDVYEDENVIPPESLDLTDHEVREYEKVNELIKTYTSRLRSWSLTLHKCYFLLASSYFQDYDPEYIQKIEKQQNPVYSSYINNPLLEDRFSYDSQDLATLLTGSHLEFPLITEESILDSYTEPESSEESTEVSKLKYLEQHYYNLAEHTRQSLLKGSTNNVKKAVNSRILSREYFARSTDNFVDDGSLLVPKTTKKFFKQLPLIKVADLAQQVIGMKVSLYFNRVQALVDQLNSQAKVINDWMNELIKILCSPLLTLDQDPNGQEYEKTIEDQDKASCYLHLLTRVLADRSSAIEGKEITTRIVSNAKQQEQRDFDVELERVNDKEFLNFLEAQRLEAKPVSKFSFNDLVREIKDIQSQINDEKSIGSQSASLELQLLDAAASSIRQIFDNQKLSSVLLLRELSTNCNFVFNARIDYFKQLQQISDSVRMPEYFQTDPEQTYNPAIEYGFRRCFESLKTIPIAMGKLVTKFKYLQSLSSPEQSSTDIDDNLMCIICRTTITIGSLTPCGHKYCKDCLEQWLSNHRSCPVCKSIITTSSIYNFTHYIPDLKANRVEASNTLEKDKNLYSIYKHMDDMVVNDIQKIKLKHSYSSKVDMIVKQVLYLKQQDPSVQIVVFSQWQDLLYILATAFKHAEISYLASYGTLTAEVGAGRPRSKYDSVERFKDPSNDITCFLLNAKAQASGLNLINATHIFLCEPLVNTSLELQAISRIHRIGQTKVTTVWMFAIENSVEESIVVLSTNKRLNYIQTLLENTSGVPTKESTPAVNSNPREPSTRISQAKDLSKAESMTLMKSGGIDTLVNRGQGEGETVSNDDLWDAFFCATSSKEMSRTMNLDTMTKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B198</accession>
    <name>G3B198_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CaNAG3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_97728</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B198"/>
    <dbReference type="GeneID" id="18250707"/>
    <dbReference type="KEGG" id="cten:18250707"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="107"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="553" mass="61763" checksum="E7950FAA1F3FEED6" modified="2011-11-16" version="1">MVSEVDNNSDNSTEPKTYLERSRSLESNEGVQRIISNLSQKAGTLGELEEGYDLQKIHTHAKPGSDVHKEDEWQYPIDEDTNLRLVVFLDGDKQNPKNFSSGRKWLYTALLGFVCFVVALGSAIVTGDMDRPRDYFGVSEEVIILASVTTFVIGFGVGPLLFAPLSEELGRQPIYMVTLGLSLIFIIPCGLAKNIGTLLVCRLIDGTLFSAPMCLIGGSLADLFEGDQRGVAMAIFSAAPFMGPVMGPIFGGLLADNASTWRWVYWTFLIIAGFMYVIFMAIVPETHGATILKRRAAKLRKLTGDDKYYTIAQLKPRTFKEVAKQSLLRPFILLSEFIVFLVTIYMAINYGLLYMFFFAIPVVYQEGKGWSASKTGIMFIPIGVGVLCSTGAAIYINKDYNRRAQKYRDRGEIPPPELRLIPMMFSCWLVPIGLFIFAWSSYPTISWAGPCFSGFATGFGFTTLYNPANNYIVDSYQHYAASALAAKTFVRSIWGAAVPLFTIQMYHKLGYQWATSLMAFISLACCIIPFLFFYFGARIRAFSRYAYSPEKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1L7</accession>
    <name>G3B1L7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_119969</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1L7"/>
    <dbReference type="HOGENOM" id="CLU_2333427_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="98" mass="11112" checksum="55945B3F22FA21CF" modified="2011-11-16" version="1">MTIDGNISTNWARGRRLYEGGSSDDSNVGSETSLEQSFVVHKDSPGLENKLQALIESQDNSDQLHQELKELAMEWFWNGYYKGFSHNKEATQSTDLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1U5</accession>
    <name>G3B1U5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_113303</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1U5"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_652109_0_0_1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="421" mass="46003" checksum="A5C6BD62AB8810C0" modified="2011-11-16" version="1">MSNLFKILESNSSDTDSSNIARQLQNNHSQINSSDPNRSYSSLPQDQSLQTYVSSVSTVSASQVPQSPYSQLMSHKAAQSVHHLPQSQYMSEMPMGSYVPPPAGHYRPVTDTANHFPPVYASQQSHGNQPQFQAASDEKLVGQDDMGGLPNLPPLASGHPLGHFPQGSPPLGSQNVYAQAPQVASQVQSQTPGQGYRRTQPQIQPSSTQPSQGSYMNTGTSPLSGSISLQANGQAGTSSSTNSVMLVGMVSGTSVVPSSNSSGSYFPIQPQSYLQTGQQYQQYSQYPQPYSQHSQQMPPKPQYTSQHQSYPPFHPRPPLHSSMGSDSSEGDKKPRTTATVHNMTPETAARNKCSVCQKQFKRPSSLQTHMYSHTGEKLFKCPWIDCGKFFSVKSNMTRHYRLHVRDMKRNSISSSTSNSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1X5</accession>
    <name>G3B1X5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_104494</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685359.1">
        <property type="nucleotide sequence ID" value="XM_006685296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1X5"/>
    <dbReference type="STRING" id="590646.G3B1X5"/>
    <dbReference type="GeneID" id="18245721"/>
    <dbReference type="KEGG" id="cten:18245721"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_2_1"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="327" mass="36519" checksum="00D9EEC16F29AB52" modified="2011-11-16" version="1">MTIEQTAVLIQDVKSPLILKSVGVPEIGPKEILVQNKAIGLNPIDWKSKKYNFAIHSLPWINGRESSGIVVKTGVDVKEIKEGDNVILVSTSYRDLRTSTFQNYSVIDYRLAIKLPSFLSFEEGATIGVGLITSAIVFYDSFKVDFNSTFQDKAILIWGASTVVGLYLIQIAKIHGLRVLGVASSGYEEYLKERGVDVFVDKDNALDNIKTEARKEQILFAVDCVGEQTSYSVLQILENHRHSKFVGIVKTPKVQTHVEVNPVSIKRFHEDVPFGSRLIEIISKYLNYKQVNPTKVKVFNGLDSIPEALTRLEKEGAKAEKYVISIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B222</accession>
    <name>G3B222_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="5">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="5">EF-G2mt</shortName>
            <shortName evidence="5">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MEF2</name>
        <name evidence="7" type="ORF">CANTEDRAFT_120261</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685394.1">
        <property type="nucleotide sequence ID" value="XM_006685331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B222"/>
    <dbReference type="STRING" id="590646.G3B222"/>
    <dbReference type="GeneID" id="18248764"/>
    <dbReference type="KEGG" id="cten:18248764"/>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_1"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="30"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="833" mass="93529" checksum="C972EC86D4A8650B" modified="2011-11-16" version="1">MIRFGVSSCKRAFSTTIILRNEKFNSIPIKRTRDIGIIAHIDAGKTTTTERILFFSGKTKRIGNVDQGDTVTDYLESERQRGITIQSAAITIPWNNNKINIIDTPGHADFTFEVVRSLRVLDGAVTILDAVEGVEAQTEKVWKQAQELELPKIAFINKMDREGAGFSRTVKEVVEKLQTRVVLCTLPYFEDRKDNVPEFKGVVDVINQKLLVWDLENDPNGRKISVLDASERPQILESIHKARESMIETLGEFDDAIIDAFLEHDENCMAISGSLINEAIRAACISNDVTPVFCGSAFKNIGVQPLMDGITNYLPSPLQIQLPQLTSHRRATKTKKSNKQKKDFQENVEVPVKMDSNLGIVINNNPSLTVALAFKVITDKIRGVMIFFRVYSGKLTTNTTFINTRTGKKHTVRNLLLMHGDEPEPVQAISSGNIGVIAGNEEIITGDTLVSHGSATTKSFSDLEMNLKLMPIDIPPPLFNSSIEPLTAGDERYMNQCIQSLLREDPSLTVFQDEELGQTIISGMGELHLEIVRERLVNDMKAKVKLRDVAVSYKETITKPNYQVIKVEDDESKVNIEITLDTFEGESSESVFAEEEGAELLDQDNNIVIFEPLATPEYMFSAIDERRWKSEYSLENLQDAIVQGLQIGLQIGGPILGFSLHSTVIRIKRWDFPVDDKSVNISRLLDITRRAVMKSIAELDPQAFTLLEPLMETKVYITSDKLGDVTHDLTQRCQANILSIEDEGTDNVEKINWAIQEAQKIYLPEDYTMKKSSESADIKNKKIVVAETPLREMVGYLSKLRSITKGRSTFDMTYLGMRRVVKARLNGIIKEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B265</accession>
    <name>G3B265_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mog1p/PsbP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113385</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685866.1">
        <property type="nucleotide sequence ID" value="XM_006685803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B265"/>
    <dbReference type="STRING" id="590646.G3B265"/>
    <dbReference type="GeneID" id="18246932"/>
    <dbReference type="KEGG" id="cten:18246932"/>
    <dbReference type="eggNOG" id="KOG3329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081345_1_2_1"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="181" mass="20500" checksum="CEC9224ED478321E" modified="2011-11-16" version="1">MIVPLFGGALDVELPDDVIDVSDFRQVPDNQEVFLVERGSGPKEDKSIIIELLESPEGSIDQVLKMHLSDLLDIDISQINDVEYIKTSNSLGEDNYISIYKDSEKNLMVIFSLVRVSKVQTDILLSFFLSIDTPNYQHLKDLDSKNISQNYASLGMEPDVRLVHTATEKIHIKNWLIFSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B278</accession>
    <name>G3B278_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF676-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_103482</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685418.1">
        <property type="nucleotide sequence ID" value="XM_006685355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B278"/>
    <dbReference type="GeneID" id="18245632"/>
    <dbReference type="KEGG" id="cten:18245632"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007367_1_0_1"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="198"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="644" mass="73921" checksum="F771F471008468F7" modified="2011-11-16" version="1">MNDPNLWYRDKDTLSIGGVIRYVVTYQREDKTVTDVFLRLKNIEKTTIRAIHMLNGPFILYCHVVPVNYDQRKKFVQKEREIHFKNSLKPGQTFNVKLPLNDNSSVQDSEHGDEFCWYIDVISQIVISKATTVLYDMTIGSNIESMKKLNHGPLATLTSLTGQSVNKYIKLNESFSPCLQVKKITGDELWSRPPTYDKPVHLIILTHGIFSNLTADMLYLKEMIETNVRDNVLVKGFSGNAGRTERGIKRMGSDQGKYLMKLIETLLSQGVNIDRISFIGHSLGGLTQLYSIKYILDNDHQFFTRNNIQPYNLVFMASPLLGILNEISFLLSWLLDLGTLGKTGRDLTLSKGKLKGKPLLEQLPDMLHSFMKQCKNLIIYANIINDGIVPLRTSGLLYLDYVTLDNVKDLKSSKETHGNDRTVGEIPAVKNNDKLHVLDKYKQFISLNFNWDVGDKKRRRLHDKILRINARGSDASFGVDEENDNSMAMSQDDAEETDLSSDNDEEIPNLNIPPKASVIESAINTLISPIPNQNYILNPESRHSPIFHDKFYKFTDLPPEKHERALFNREKRQVRIARKYHQELNWRKILVRLPPDAHNNIIVRRRFSNGYGWGVIDHLCELFNEENDTERVGTSRLEKIKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2B5</accession>
    <name>G3B2B5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113418</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2B5"/>
    <dbReference type="HOGENOM" id="CLU_2589517_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="80" mass="8742" checksum="9D12D5D3A1D8EACB" modified="2011-11-16" version="1">MITSVLVNGGPGSAAVETLLQPLGCGKLDPKTLITYIRARCCVVHMHNYHKGPHKNHSRLIKSSTEMKRINTASENATFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2M5</accession>
    <name>G3B2M5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_97569</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2M5"/>
    <dbReference type="STRING" id="590646.G3B2M5"/>
    <dbReference type="GeneID" id="18250695"/>
    <dbReference type="KEGG" id="cten:18250695"/>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022453_2_0_1"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="98"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="265" mass="29803" checksum="3238AB2BA2AAFDA7" modified="2011-11-16" version="1">MSGLSSNWARLQSNITPKSTRKTKKTVIKRKAPYTPKETEKVASIITSSNSPASEIQLSTIASALWTNEHEISEKDIENVSSTKAPIQTSSKKQLPGKYLAIDCEFVGVGPEGEESALARVSIVNFYGYTVYDKFVKPREKVTDWRTWVSGVTPKHMKDAATFKQAQEETSKLLDGKILVGHAVHHDLDALFLSHPKYMIRDTTSFKPFRAIANGKTPSLKKLTKHFLKIDIQDGSHSSVEDARATMLLFRLHRKDFEKTLKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2S6</accession>
    <name>G3B2S6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_134063</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2S6"/>
    <dbReference type="STRING" id="590646.G3B2S6"/>
    <dbReference type="GeneID" id="18249762"/>
    <dbReference type="KEGG" id="cten:18249762"/>
    <dbReference type="eggNOG" id="ENOG502S1Z7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036641_0_0_1"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="371"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="436" mass="47632" checksum="FE2E3A24F128C525" modified="2011-11-16" version="1">MDQTNWESFTPVKSDYFELNDQLIDIKAETENDQFLLQQLDHNLYDGVTDGDGDGKHAPKNDALTKLNDFSLDNYNFEDLNHDMSELGYRHGDAPTGGDIAGAGAGAPSTYRHNSSSAFPPTGSVQNTPSMLPHKHQQLVNHNQVVSSPILPSQNDKSFNNQHYYHKLSRNKSKEALESMPQSQHIRPDVIFTPLMSPHHTPADSRGKFAVQASFEPLTSPALAAQTHGPSDAVSKRRSSSSVFSTVNENKPVSFKRRTPHGTPILPSNGSSSGVDGGTHFEGLPDASMSVSSSSTPMLPPQSYKKIDPESSTTSPQMMGFTMGKLAKQKSQPPPPVDSPPTSSRKSSYDSSRSNDTSPSLAPMGKEKPSTKKASHKLAEQGRRNRMNVAVQSLGLLVPQKYHERVAIPSKATTVELASSYIKDLVREVEELKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2U9</accession>
    <name>G3B2U9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_113543</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2U9"/>
    <dbReference type="STRING" id="590646.G3B2U9"/>
    <dbReference type="GeneID" id="18247012"/>
    <dbReference type="KEGG" id="cten:18247012"/>
    <dbReference type="eggNOG" id="KOG0739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_1"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000014">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="11">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="164"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="435" mass="47979" checksum="3B38CB8434EF6E4B" modified="2011-11-16" version="1">MSGGSDFLSKGIDLVQKAIDADTATRYEEAYKLYYNGLDYLMLAIKYEKNQKSKELIRSKFTEYLTRAEQLKDHLEKQSSKSNSAENSSTNGSTKARKPGETSGDDDDADTKKLRGALAGAILSEKPDVKWSDIAGLESAKEALKEAVILPVKFPQLFKGNRKPTSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFTMARESKPSIIFIDEVDALCGPRGEGESEASRRIKTELLVQMNGVGNDSSGVLVLGATNIPWQLDAAIRRRFEKRIYIPLPDEDARTRMFELNVGDVPCECNAQDLRALASMTDGYSGHDIAVVVRDALMQPIRKIQQATHFKPVQDQDGNRKLTPCSPGDEGAVETNWMDIGTDELQEPDLTIKDFIKSIKSNRPTVNASDIENHIKFTDDFGQEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B342</accession>
    <name>G3B342_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114110</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686387.1">
        <property type="nucleotide sequence ID" value="XM_006686324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B342"/>
    <dbReference type="STRING" id="590646.G3B342"/>
    <dbReference type="GeneID" id="18247267"/>
    <dbReference type="KEGG" id="cten:18247267"/>
    <dbReference type="eggNOG" id="ENOG502RQ04">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1695249_0_0_1"/>
    <dbReference type="OrthoDB" id="4003242at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="155" mass="17815" checksum="E5491E967AD4B104" modified="2011-11-16" version="1">MFSRSIRDASKRQVKLLRRYNHHDHGHHEPVKETEINLAKVFGIAVLGGVSLIFYKNYKAGNDPIVRTKLYNEVEERPNLRNENYLKRYQTSFIKGYIRDKGGVGQKQYNRMAEGALPVNLIPTHSTDGNQFGSGIKLGELGPRRENIQYFSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3B9</accession>
    <name>G3B3B9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FIST domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114154</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686446.1">
        <property type="nucleotide sequence ID" value="XM_006686383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3B9"/>
    <dbReference type="GeneID" id="18247292"/>
    <dbReference type="KEGG" id="cten:18247292"/>
    <dbReference type="eggNOG" id="ENOG502S491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061606_0_0_1"/>
    <dbReference type="OrthoDB" id="4080562at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38113" checksum="77C7A3664F97D82C" modified="2011-11-16" version="1">MYTHIRHFRSSSRLCDSFWKTVVHPTTSLIPHPQFAPKSVILLSTPSNLPAVTQQAIELYDSKVQVIVAGIDTIKGSRNGVSALWLDSHLDISGVLYQEAMTKNWKKTDSNLQLNFSKNSIHLPLANSLFSTGNLITLFHLDPRGSPFHDKLLKSISINLPDEVIRPSLIDIQDRWTPLFDEPMYVTNCIGNLIKSINNKSAAKFLETNSKLMSLKSKETEVYVKLTQTTNGEPMENRFQVIAGGGGWGPKADTIVISPDAKVAKKDQVEFFMLTPEDKTRPLQMQDFGGFEFECSVPETDYTVDDGEEQVFDSFGCGSEAGFKHNSTNHKSPGERVSFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3H1</accession>
    <name>G3B3H1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114209</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686710.1">
        <property type="nucleotide sequence ID" value="XM_006686647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3H1"/>
    <dbReference type="STRING" id="590646.G3B3H1"/>
    <dbReference type="GeneID" id="18247312"/>
    <dbReference type="KEGG" id="cten:18247312"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024643_0_0_1"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="251"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="581" mass="64565" checksum="DF0718FD1AB7880B" modified="2011-11-16" version="1">MNKFDEPLSLKFIHKPARTQELVNRKVGEQKTRRNSDTNKQLVLGGDTKSTNSLGPGKDSNTGDTSNMRNFSFFSQHVPDLHDDTASIDSNPDASLSQAGLGDEDVFRYKLVRKKSGEILKSNLKDPSYFDHTVSKSLPTTPSYKQVHFGDASDVRYFNKKDKPAAISASNSPTLQSPDFSLNVSEDEASDASFDSGDDPADERTRDVNDLLGSSRHSFFNGSTAYPNPKHSHLIDWNLDLVNFSPMDYDTNISRHVPVFLERVFISIDKKYLLGHVAVKNLSFEKSVTMRYTFDNWGTIIEIPTIYVPDIPTVLRSNGYDRFVFKVQLNKMFNNFGANMHFQKNNYKFCIKYVANNTNYWDNNSMRDYEINLTKIITQANSPVARTNFSDNSVFNRTGSADSLTSLNSKGFKPRYSSSYLRRRSSDSKLSTLESDADYVKNNFYLSSPLLSNYSSGSFSSDVLNPSKSNTSTDTLIPNKNFLNPHDSNPLDLKSLNASLFTDNDNYNSPSYQQLIDNYCFFTPGGSQPQKSSSGSNQKESGNPSSSSSSGSNSASEPAGGLDGSSEFSSSTFTVSSLLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3S9</accession>
    <name>G3B3S9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_93237</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3S9"/>
    <dbReference type="STRING" id="590646.G3B3S9"/>
    <dbReference type="GeneID" id="18250266"/>
    <dbReference type="KEGG" id="cten:18250266"/>
    <dbReference type="eggNOG" id="ENOG502RAAP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018775_0_0_1"/>
    <dbReference type="OrthoDB" id="4015271at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="740" mass="86262" checksum="FDFD2CB931B309EF" modified="2011-11-16" version="1">MKPRMSYHISVRRGALNTPLCASVVVFSRGISDKSKWYDSQYTNYFLDVKKLTHFFGHKPIFSSGPSMRTPVSMTFDVEPENSAVANEFVRLHREQQYEQLAEFVKSQVAYDKVIDQKVLTQTMDFGDLNMGGINVVPALHLQPLKREAHKQISCYHTILKAYEPYMLNDAMFQELFIRSSYHMGDVDSLTTLSEVYLHNPCLNEQTLNYILNGFAVNYEPEQAKLFLSEVTNMRKNLNVILLETVLMSLSKYGALFEIIINCVQTWILSRNTLPSARAMAVVLSQGYKYGTVNEVREIEQLIYRYGLNEDFRIREAKLKYQVCNRDKIAFKKQILAEDVDEVNDIIRMLRSSNKVAELTEFYHSMVDFFVRYTTSTTHIEHILKQMSIDGIQTDKDIYRSLMQKYLIHEKFLDLANFLESSNMSKNVPFELEHLQVIFETFVRSYPHYTEEFYYRFLRFVKMSSLSNVDKQSLISVTKIHSLQSQLKPFGLGSKGLNPHKYRSKDWEPMPWILKKGRPVSYPKQVQFRVEKGFGDLLKRGLKPDFHVIEETFRRSSLFFKTRILQLAQDIRMPTKNQNRLSVINLHFATKDELSAFFKYHSQTLNSNNKISFSRLLSNKGLHAEAVAILDSINTNEIPDSSLSVIFVYRIRALFQLRQPQEILQAMEEFPVHDVTISPYLLKQSVQLERKFVNCEDMSECVGRLRGFIGDCKVVLEKDRADLEIRLEQVLQYVDTWIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3B409</accession>
    <name>G3B409_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113938</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B409"/>
    <dbReference type="HOGENOM" id="CLU_2960543_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="59" mass="6887" checksum="71B8CFAD60F4AC76" modified="2011-11-16" version="1">MFRLFRTFLTPSRTIPVKTQESWTRLNQQVPEQNLSEYLSQRPCLGLTLPASQRISAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B412</accession>
    <name>G3B412_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_113940</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B412"/>
    <dbReference type="STRING" id="590646.G3B412"/>
    <dbReference type="KEGG" id="cten:90982144"/>
    <dbReference type="eggNOG" id="ENOG502QRAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049915_1_0_1"/>
    <dbReference type="OrthoDB" id="3981301at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000846">
        <property type="entry name" value="ATP_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="71"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="199"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="318" mass="36342" checksum="452244F3BAC9C2E0" modified="2011-11-16" version="1">MFYPLPDDFFIQLKNKYDEAVANNFLNFNGDSVKNESLKVTLGDDSNSVTIDLQYSTIHSLMLRPEKGDFKKNPFEDPEPELTIIEDFGAQNQFRIVYNKFPVVPRHIMLLTKEFKSQTTPLSPDELIGTFSILKKLSEDKENQWFGFYNCGEASGASQPHKHVQFMTLPKDFTPFPLLAVENSDSFIPTTKREPLQLPELPMAHFIAKLPPKLDDLDEESLVLYFSSLLQRALTVLRENDAKSISYNVIMTTSFMMVVPRSHGKYEDLGINSCGILGLFLFKSDDLLARVKESTPQKVWQDVGFPNTFGQPSDEYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B433</accession>
    <name>G3B433_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_113809</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B433"/>
    <dbReference type="STRING" id="590646.G3B433"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080880_2_4_1"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="180" mass="19946" checksum="A853AB7469CB8FD6" modified="2011-11-16" version="1">MIKQVSKIAGRRLTPAQCSLVMGMSVKNLGSGALLNHLPVFQSTKSPFSIISRPYTVDRLGNDIDSKIDQISNAQYDDISNHYLDTLSDEIDLISETHENVEFDLNQGVLTLSTGSGTYVINRQPPNKQIWLSSPLTGPNRYDLIGGKWKSLRDNGELTQLLSRELSDILGTSIQLQLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B444</accession>
    <name>G3B444_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_105175</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B444"/>
    <dbReference type="GeneID" id="18245789"/>
    <dbReference type="KEGG" id="cten:18245789"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000335">
        <property type="entry name" value="Siderochrome iron transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="598" mass="65989" checksum="E8F569C8F27A91F2" modified="2011-11-16" version="1">MPGVSQFFKKRSDREVAEAAFNGPEPVGDQEKNSDLSRSNSKEDDIHSDQVSIDAAPGVQKAEAITLVWDKKALYITYVWIWVCFFMLAFQSAIGNNVIFYAYADFSAAPQVSTAGILATIIGGVLRLPLAKTLTLWGRCEGFLVFVVVYLIGIIIIASCTGPSSYAAGYVLYWIGYDMIYMILDVFIADTSGLRNRAFAFAFASTPFICTAFTGPLAAQSFLTTGGWRWAYGAFAIIQVFVFVPLAVVFKFYEKKAEKLGQIKKNPSGRTIIQSIVHYIHDFDVVGAFILMAAFILFLLPFSLEQYGRAQYKSATFIAMVVIGVCLFPVFAIWEKFFARTHFVRWELFKKRTVVGACCLAAILYFSFYCWDLYYVYFVTVVYNLSTSDAGYMGQIYNVGSCFWGVVFGVWIRYTKHFKYTCLCFGLPLMFLGAGLMIRFRGQDSNIGYIIMCQIFIAFAGGTMVIGEDMAVMAAADQDGIPMMLALIGLFSSVGGSIGYAVAAAINANVFVDALTKALPAAQKDQAYTIYLGGVTTQTNATLYPVGSEARDAINYAWGQTQRDGAIAATCILVLAIPAIAVWKNYNVDKKQIKGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B484</accession>
    <name>G3B484_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_113948</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B484"/>
    <dbReference type="STRING" id="590646.G3B484"/>
    <dbReference type="eggNOG" id="KOG0816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071690_0_0_1"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="217" mass="24943" checksum="A12B335FD2246424" modified="2011-11-16" version="1">MPRSKRSKLVTLAQTDKKGKENKERIFDEVRSALDEFKYVFVLRLDDVRTPVLQEIRSDWAGSRLILGKRRVLEKALGDTTAEEYKDDLHQLSKLCDGVVGLLFTNEEINTVEDYFNAYTKQDYSRAKTRAPIDFTIPEGIVYSRGGQISIEEDVTMSHSLEETLRNKFKIPTKMKSGDVLDVRQALILKQFGIAASEFKVQMLGYYDGENNKVEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4A4</accession>
    <name>G3B4A4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113959</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4A4"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="280" mass="31388" checksum="F346F5A67561A866" modified="2011-11-16" version="1">MSKFVTLNNGAVIPSVGLGVYLTTAEDASRIVYESLKAGYRHIDSAVFYENEEAVTGAIAKWLKETGTDRKEIFYTTKILKFGDEAKPEIEKCLEKSKSIGYIDLILIHAPLANSEGRHGAWVALQDAVASGKVKSIGVSNYGAHHLKQLLEYPDLKVKPVVNQLEIHPWLARKELVKYCRDNGIEVQAFSPLVRGYRFGDEDVVALSKKYNVSEAQIMIRWSLQNGFIPLPKTVSETRLVSNLDVFDWSLSKEDMALLDAKDEHFVSMPEWDPSTNPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4J4</accession>
    <name>G3B4J4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="6">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_104793</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="6"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4J4"/>
    <dbReference type="STRING" id="590646.G3B4J4"/>
    <dbReference type="GeneID" id="18245756"/>
    <dbReference type="KEGG" id="cten:18245756"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF245">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="98"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="546"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="668" mass="73870" checksum="8EBE630F1E5EBF49" modified="2011-11-16" version="1">MTNTEHKVVHEANGCQSHDTPKEFYDRQPEPGFIKDIDQYYQMYHKSIQQPDEFFGPLARELLHWDKDFAKVRSGSLDTGDVAWFLGGELNACYNCVDRYAFQTPDKLAIVCENDDEKDSHSLTYKQLLFEICKVSQVLQDWGVKKGDTVAIYMPMNSQAIIAMLAVARLGAIHSVIFAGFSSGSIKDRVNDASCKALITCDEGKRGGKTINIKKLCDEALVNCPSVEKVLVYKRTGGNVYMESGRDFYWDEETSKFSGYIPPTPVNAEDPLFLLYTSGSTGTPKGVVHTTAGYLLGAALTTKYIFDIHQQDVLFTAGDVGWITGHTYALYGPLLLGVTSVVFEGTPAYPDFGRLFKIIDDHKVTHFYIAPTALRLLRKSGEAEIAKYDLSTLRTLGSVGEPISPDIWEWYNEKIGKGQCHIADTYWQTESGSHFIAPIAGIIPNKPGSAALPFFGIDTCLIDPVSGQEIHGNDVEGVLAIKSSWPSMARSVWKNHGKYMDTYLKPYPGFYFTGDGAARDHDGYYWIRGRVDDVVNVSGHRLSTAEIEAILIEYPGVTESAVVGINDDLTGQAIVAYVALKDNAVDNLDELRKALVMLVRKEIGPFAAPKSIIVVADLPKTRSGKIMRRILRKISSHEADQLGDISTLANPQSVEGIIECFSAQFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4K9</accession>
    <name>G3B4K9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_121899</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4K9"/>
    <dbReference type="STRING" id="590646.G3B4K9"/>
    <dbReference type="eggNOG" id="ENOG502SDAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119603_1_0_1"/>
    <dbReference type="OrthoDB" id="8189076at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="122" mass="13949" checksum="B75ACBB2D873EB4B" modified="2011-11-16" version="1">MNTSSKFPEGIKIDDITSGRIDPQLIYSEIDRLKYEINVLRNDMSVFIRALATIPEGSNQQDYYRSVAGKLKVVQNSIKEYCAQYNKLLPIINLSQIKLGHEVEVLPQNLKNDKAKVKPVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4L0</accession>
    <name>G3B4L0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_105087</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4L0"/>
    <dbReference type="STRING" id="590646.G3B4L0"/>
    <dbReference type="GeneID" id="18245776"/>
    <dbReference type="KEGG" id="cten:18245776"/>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_1_1_1"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="342"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="699" mass="74917" checksum="37783E4651B1A6B6" modified="2011-11-16" version="1">MSSALKDTFERCKKENRNALVTFITAGFPTVEDTVPILQGLQKGGADIVELGVPFSDPIADGPTIQVANVKALENGVTVPKCLELVRQARAAGVTIPIILMGYYNPILKYGEEQMIRDTAAAGADGYIVVDLPPQEAIQFRSTCSKYGLTYVPLVAPATTDARLKVLGEIADSFIYVVSRMAPTGASTEVSLGIPELCARVRKYANGSPLAVGFGVSTREHFLQVGKDADAVVIGSKFITLMGDSAPGTRGQAAYQFARDILGENYVAVPPTSYANTTKSAKELVPVLEESHKHNPKFGDFGGQFVPEAMYTCLAELEQGFESAIADPGFWDEFKGLYSYIGRPSSLHKADRLTEYAGGAQIWLKREDLNHTGSHKINNALAQVLIAKRLGKSKVIAETGAGQHGVATATACAKFGLECTVFMGAEDVRRQALNVFRMRILGAKVIAVTNGTQTLRDATSEAFRYWVSHLQTTHYVVGSAIGPHPYPTLVRTFQSVIGNETKQQFKELNNGKLPDAVVACVGGGSNSTGMFSPFEKDISVKMLGVEAAGDGLDTERHSATLTAGQPGVFHGVRTYVLQDSDGQVHDTHSISAGLDYPGVGPELAFWKSTGRAEFVGATDAQALLGFKLLSQLEGIIPALESSHAIYGGVELAKTMSKDQHIVINLSGRGDKDVQSVAENLPKLGPEIGWDLRFEADPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4S7</accession>
    <name>G3B4S7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_93366</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686177.1">
        <property type="nucleotide sequence ID" value="XM_006686114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4S7"/>
    <dbReference type="STRING" id="590646.G3B4S7"/>
    <dbReference type="GeneID" id="18250282"/>
    <dbReference type="KEGG" id="cten:18250282"/>
    <dbReference type="eggNOG" id="ENOG502RZJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005934_0_0_1"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="847"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="972" mass="111783" checksum="8B59C23C8B9ABD7C" modified="2011-11-16" version="1">MDFQEDLTVSGDTLDKSGKVKPVCTFCKRRKIKCDRGIPCSSCIRFNNKECVYVDPNPKSIKKKASKPSKKTLESEIEILKERIGELQKSIVNDRGDVVGETSPNGKPPLASYSLDHATEARYENDFDELMQLVEEHSWNESFNLLNQGSVVFDHEPLGRKNFGFFSWKACYVVDPALKYMGAYAKRLHQEGKGFYGSNDLSEANTRRINGFFSYNVEPLVHKNETCVLPNCHLCSGSNSMEVEEPPQKVNRSSSILNPINVLNNKAETKFSELFELQRKIELFLPSKRIILTFLNRFFKTLYTFMPVIDESDFKSQVCRLLEGTELDERPVSLRIKTKLDFAYLGILLLLLRLSYLALLPMNQWTKSAIKDHYMEEEIEEVRMLLNHNIGLDAARLSQDCVGVFNLCGVINLTIFQLVLVTRTYSIFAPEKGDGPEQGEAQILNTTLFQMAYGLGIHREPNNTTVFQDEKSKNLIRKMWSMLLMLDLNHSLEYGDPLNVSRFSYDTLYPTFRKENSNLIDLNREKFVVECYQFMEICYKPLIGFISELLDVNATYNVTTLCKKLRYLRATLFNPQDGLITSWVRKFDASQETNTMLNLTKYKIQLQFSHFICTLYFHLYNYFEKKKLFEVAFYYLFNLMNKVLLVLFPFYFELVNLKSVEPTIDFVLVPGIQSLLHKATLFLLSLMVRIKINIIASMDAPNHMLLFRSDMQYRRNFDSLCSLFHKLLEISSCLTSIADAYSKKYYYSWMISRVNKFFLSLIKSPDFREIVYNGSASFPIFADFEKVDKLQELLNLCLETKAKLSSSNPNIDKSYTRNDADLFDSSLVNPYKETDISPFNDTNYSSTVSSNFEKESMDRTTNDGRNTMSSDMGDNGIPSEEVDNIWLQLLGVRDGSVNEAEDFLGHDIPQTSFSYPEATRVPPEMSKQMGNMNIQSPNFNFEQSPFLGANGELTQKSVVDAFLIDELFGDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4V4</accession>
    <name>G3B4V4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III 40 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_113900</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4V4"/>
    <dbReference type="STRING" id="590646.G3B4V4"/>
    <dbReference type="GeneID" id="18247172"/>
    <dbReference type="KEGG" id="cten:18247172"/>
    <dbReference type="eggNOG" id="KOG1521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_0_1_1"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000005">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="53"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="336" mass="37684" checksum="681E4D2B12AD385A" modified="2011-11-16" version="1">MADNNIVGIEYNRVTNTTSTDFPGHSSNEDQSWDIEKIKNSLEVKISKLDERESNFDLVHIDTSIANALRRIMISEVPSVAAETIYVFNNTSVIQDEVLAHRIGLIPLKADPDLLTWVDTAQDEKSKYTDENTIVLTLDVTCTHNPNAPKGSTNPKELYRNSHVYAKDLKFEPQGKQVELFKGNPVTAADPNILIAKLRPGQEISLRAHCILGVGSDHAKFSPVATASYRLMPVIDIKQPISGEQAKRFQRCFPPGVVDIDSKGEAYVKDARRDTVSREVLRHEEFDGKVKLGRKRDHFIFNIESTGGMPPEEIFIKSIRLLKSKADYLRNCPIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5P8</accession>
    <name>G3B5P8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CANTEDRAFT_106309</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687072.1">
        <property type="nucleotide sequence ID" value="XM_006687009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5P8"/>
    <dbReference type="STRING" id="590646.G3B5P8"/>
    <dbReference type="GeneID" id="18245879"/>
    <dbReference type="KEGG" id="cten:18245879"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="24">
        <location>
            <begin position="178"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGV63279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="564" mass="63501" checksum="1080BA510EFDF65C" modified="2011-11-16" version="1">MSVSIEEVRKHNSKADCWVIIHNKVYDVTDFLSEHPGGSGIILKYAGKDATKAFDPIHPSDTLTKYLPGSCFKGEVDPDSIKKLKQKTSTSKKTPQATKEATKATQATQATPVVSADESTVDEFDVEYDEQDNKRPMNFPIPANLAANEDEDGEYDDDEDDPPDAYELNRRKYAKAKPDISQIYNLNDFEFVARHTMEKTAWAYYSSGCDDEITLRENHSAYHHYFFNPRVLVDVSAIDISTTMLNDNVSAPFYITATALGRLGHPDGEKVLTRSAAKQDIIQMIPTLASCSFDEIIDEATDKQIQWFQLYVNSDREICKSIVQHAEARGIKGIFITVDAPQLGRREKDMRSKNFEDLSHVQDTDDDSIDRSQGAARAISSFIDTSLNWEDIKWFRSITKLPIILKGIQTVGDSLKAIDYGVDGIVLSNHGGRQLEFSRPPIDVLAELHYILKAKKLENKLEIYIDGGIRRATDILKALCLGAKGVGIGRPFLYAMSTYGDDGVYKAIQILKDEMIMNMRLLGVSRIEDLNDSFIDTRFQNRSMPNDRLFESVYEPLESPPFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5X1</accession>
    <name>G3B5X1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_135151</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the YME2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5X1"/>
    <dbReference type="eggNOG" id="ENOG502QS0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007861_1_0_1"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="219"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="15">
        <location>
            <begin position="400"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="852"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV63325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="891" mass="102890" checksum="BD3387AD8E0CEC47" modified="2011-11-16" version="1">MFKLVNKPRLWGQLRFLSNRKAQISMFRDVRHFPAFQKSLRNRMYHTDIERIKKETDLNDTDVSASATGVVDIDKTKEVLLYFDHIYDRGVSSFKFKQYLNLLIPDKDIDTLKKEVWEMANKEDNPLPESTSIMDFIPLRRDSGAFVKFSVPEGYSPKEVIAKICTNVSNSENDANNFKKLYMRLTRNNPTTFQVKGTPWIEDLRRFPSSKLKVKFEGPSLTEEELYILFRRYGTIIDINPASSSNPIALIQFKRLRSSICAKNCITGLSLDGGKTTLHLQYVPIERVNYITDFISNHQRIAVPILLALLATVAVLIFDPIRQFFIEEKIQHRLSLSYYRDSRYLKLFTRPLVTIQSWFFTGYDYIGESLDSKCHQDTIANESDLDNEENLDSNNLWHERSDKIKQLKLWILENVSTFIIVRGPKGSGKREMVVQDTLLSDAQLKQKVLYLDCDEIIKARSDTKLVESIASQVGYYPVFSWLSSISQFIDLGVQSVTGQKSGLSESKETQVKNIFSLTTQALRSTALREYGEYERQVSARKRRQEHRKRSNPGLEIKLDDVMKPDEYLQQRPEAKPVIVINKFASKSRNSSNDFIYKMMSDWAATLVQSNLAHVIFITNDVGSISVLNSSLPNQVFKTITLNDASETSSYYYVMNKLKDLRYEKFNSDIIKETLKPLGGRMLDLQAFIRRIRSGETPQQSLTEMVSQAAEQITTFFLYNNTKPGDEDFKNWDPLQVWELIKLLSSKDIIKYNELTKSPLFKAGNNTMEVLSALEKNDLLTLRRENGVLNEIRTGRPIFKAAFKTLIDDKDIFASLEIGHYNNLAKLETAKIKDYEEELSKFHFKEYKLDNRLKYLVDKIEESNTKVNQYEQTADDIKKGVSNHSTSFLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B666</accession>
    <name>G3B666_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114708</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687188.1">
        <property type="nucleotide sequence ID" value="XM_006687125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B666"/>
    <dbReference type="STRING" id="590646.G3B666"/>
    <dbReference type="GeneID" id="18247544"/>
    <dbReference type="KEGG" id="cten:18247544"/>
    <dbReference type="eggNOG" id="ENOG502QRYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014401_1_1_1"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="58401" checksum="FB37C73A9CCFAB66" modified="2011-11-16" version="1">MFYYEASTKRRFIQCACAILWCLLAGGPIFGFAALKPVLIREGVYESVCDIQTDAVRGMFDFEAPQSLTSLLLGQAVGVQEEQTVAKCVAQDLKLNMMFTVGAVVTNVSALVIGKLLDDFGPRFCGSVGAFFLFLACFVFIFASQIDKSFIGPYFDPYLVGYASMALGGPFSYISQFQLSNSFPKKSGTVLALLTGAFDASSAVFLVYRIFYNRSNGVFTINKFFQCYILVPVFIAVCQVFVMEKDSYKTPPETDLCVDDVPDGLASSAAPISETDPLLNGENHPVGHHRRDSIGDALKQPYAEEGEANLVKYSGGIFGILHGYSAQYQLRTPWFYLMCLFATIQMLRLNYFVATISTQYTYLLSSVALSEKLVKFFDVALPLGGVLSIPFVGLFLDSCSTVTVLAGLLGISLIIGALGLTTHYVTLFINVCLFVVYRPFFYTSVSDFCAKVFGFDTFGTVYGAIICTSGIINFSQSVLDKWTHTTFKMNPTPINVILVVLTALIGGVNVAYVNAETELYKKRKQAQLSQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6I7</accession>
    <name>G3B6I7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_106911</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6I7"/>
    <dbReference type="STRING" id="590646.G3B6I7"/>
    <dbReference type="eggNOG" id="KOG0159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_2_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="63302" checksum="381CA33E8A1A348B" modified="2011-11-16" version="1">MLKEVLLGAYTTIESNKSAALVFLFAAVLVYNLVLYPFYISPFKSIPGPYLFRISRLPCLHYQRTNQWVYKVHELHKVYGDVVVLAPNEISVNGDPKYLNDIYTKNFPKSKFYENFRNHGFKDNMFSSLENDRHLNYKKNITSIYSKSAVFNGKNTTRSVILKKVEKLLRNIKESSGGKTTNLGIDVYSLFGALALDVVTAFELGSENSTDLLDFPEKRSIVTYHRYVASMVFYTTLMPQFWDMAATELIKKSSAIVEKWQLGIYHKAEENVPVLTPEQNTTTLELLKKNNLTGEYAYSFLSDNIFAGHETTAIQLTYLTYELSRPKHHYLQRMLKEELDKEFGAPSRETDVIEDFERVDTLPVLNALILENSRVHTSIPGAEPRVVDRPYTVNGTVIPPNTVISVQPYSYHRVEKVFPKPDHFVAERWLPRENESESQYASRFKLMNKYMIPFGKGVRMCLGMNIAQIEMKMAIANIYWHYNSKICENWAQIVEYDDLEKLPEPIKTANQVGDKLTDESKMTMFDTYTTRPYDDECWLEFYRNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6R0</accession>
    <name>G3B6R0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_98207</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6R0"/>
    <dbReference type="STRING" id="590646.G3B6R0"/>
    <dbReference type="GeneID" id="18250750"/>
    <dbReference type="KEGG" id="cten:18250750"/>
    <dbReference type="eggNOG" id="KOG3155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094365_1_0_1"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="175" mass="20074" checksum="1389F7C8B1DA95B0" modified="2011-11-16" version="1">MPAYHSTFLSESDTSNRTVGNMVLLPFKTKFRGPSYPTEQEYDIVEEVLDLFRANSFFKNFEIKGPADRVLIYGILFVSECLSKLNKTVGLKEATRILNNISLESFALPGDIGFPLSSMYLPPANKNEAELLRGYLQQLRQELSDRLLKRIYVASDVPSKYWLAFSKRRFMNKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6T8</accession>
    <name>G3B6T8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DFP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114328</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6T8"/>
    <dbReference type="STRING" id="590646.G3B6T8"/>
    <dbReference type="GeneID" id="18247374"/>
    <dbReference type="KEGG" id="cten:18247374"/>
    <dbReference type="eggNOG" id="KOG2728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042326_1_0_1"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10300:FF:000002">
        <property type="entry name" value="Phosphopantothenate--cysteine ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="3">
        <location>
            <begin position="186"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="38269" checksum="17FC8FFE0275BBCE" modified="2011-11-16" version="1">MSGKSYHTSNPETEGAIDRNVPDFPIAGQSEEESYFRTHSAPSYLPEIQAQLESFIEYHLKNTGKRIALVTSGGTTVPLENNTVRFIDNFSAGTRGATSAEYFLENGYAVIFLHREFSLLPYSRHYSHTTNCFLDYMVEKDNKIEISPDFAPEMLQVLRKYNAAKSSNSLILVPFTTVNQYLFTLRMGSEALKKMGKNALFYLAAAVSDFFLPQSRMPQHKIQSQASGKLIVDLEQVPKFLSRLVDNWAPRSMIISFKLETDDSILIKKATAALDKYQHQLVIGNLLQTRKKEVVFVKPDSSQDWVRLTDKQVETNVEIESLIIPKVVQEHTLWINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Z9</accession>
    <name>G3B6Z9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_106835</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Z9"/>
    <dbReference type="STRING" id="590646.G3B6Z9"/>
    <dbReference type="GeneID" id="18245919"/>
    <dbReference type="KEGG" id="cten:18245919"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="51916" checksum="7C136F53EED4CC88" modified="2011-11-16" version="1">MSEERLLNGDFETYAAAESEVTLLGPEATFEREFKFTVNSSGPLIVSFFLQYLLSVTTIFAAGKLGPKELAAASLAVCTFNITGLAVYQGMSTSLDSLCSQAFGSGDLHNVGVYFQRCSLMILVVTIFPLSIIWWFSASILEPLVGDAELAQLAQLYLRISTLGTPGLFLFETGKRFLQAQHIFHAATYILMIVAPINILLNYLLVWSPTYGLGYIGAPIAVSIVYWLMTLLMIGYIVFVDGRKCWNGFDWQKATINWIPMLKLALPGVIMVEAEYLAFEVLTILAASFGTDSLAAQSIASNVGSLAFQLAFAVAVAITTRIGHYVGSHNIGGARRVLQVFLVLGVFLSCFNFTVLFFGKTFLAGVFTKDTGVINIASRLIGLAAINQLADSFNVLGAGVLRGQGKQRIGSILNIASYYFVALPIGYLLAFPMGYGVEGLWIGLISGVAFLAASEGYVIYYSNWEHIIAESMNRHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B714</accession>
    <name>G3B714_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114382</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B714"/>
    <dbReference type="STRING" id="590646.G3B714"/>
    <dbReference type="GeneID" id="18247399"/>
    <dbReference type="KEGG" id="cten:18247399"/>
    <dbReference type="eggNOG" id="ENOG502S9GT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131611_1_0_1"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="124" mass="15097" checksum="25CFF9D7F52ECFC3" modified="2011-11-16" version="1">MVYLGNHVFRGKKAQQAYDKTFAGKYQRLLQRNHFLYFGLPFMLSIVAGSIYLQNFTAVKWEKYDAKYRQLNEAEMLDMIENKRKVDKKNDYYRLQGFVDEQKDNDFDYEMIRVKRKKEDEPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B765</accession>
    <name>G3B765_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114427</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686906.1">
        <property type="nucleotide sequence ID" value="XM_006686843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B765"/>
    <dbReference type="STRING" id="590646.G3B765"/>
    <dbReference type="GeneID" id="18247422"/>
    <dbReference type="KEGG" id="cten:18247422"/>
    <dbReference type="eggNOG" id="KOG3280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_1_0_1"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="244" mass="28045" checksum="9207BA84442DDF82" modified="2011-11-16" version="1">MPSLQKYQVNVARHVKSMDKNITANLIRHESIVTTRAKAKRAQSKVERFLSRTLNENQSMLEQPLQYKLKNNKNLRYLQPPDMTDVGPKVLNELAQRYPNRSHGFTRIIKLEPRLGEDKAPMSVLELVDSNLEVKFWYYAKIAARLQLQGLELDSLTANEIRKLTTFRNDGEVVFAKAVETAKVEFFKYNPETEQVEDAEIQENLKNVPRPFSRDRTVSKKFQTKPRPAASASVELPKSPFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B781</accession>
    <name>G3B781_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_94477</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687757.1">
        <property type="nucleotide sequence ID" value="XM_006687694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B781"/>
    <dbReference type="GeneID" id="18250403"/>
    <dbReference type="KEGG" id="cten:18250403"/>
    <dbReference type="eggNOG" id="ENOG502QTM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014851_0_0_1"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="702"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="786"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="812" mass="91693" checksum="772D6642B0AEF273" modified="2011-11-16" version="1">MRDSNYKSISNNRAAVTISSTVYDRRALDVTSDRPLVNSLNHLTYLVSSSAKVRETLSTDGGIERLIEILHECNNCNFGSSDNIFTSEKKILTAWKWTLGFQCLVLIGTRGTESIRQRVVRAGMLPIIATVLDNYITLHDRAFIQANKGMTLQSSGFSSQVLGGSTGTQEASQIQQNIPTATAQPQGDLQEIRPVGGITDNTEEIATDTDLSGNLNFLVQFETFQNNFRMDDSTSAAAAMAASSSVQPHSFFSGRHPDSLTNEDYESLSIEQLFKLVRTAETCDLLDSQNVNNIRRRYLILIIMKKLKAEKEGELLDTRFLNNTDYDMDNSLQFLSDMYLQDEKSAYLSSLATSKASPRSFTETGVIIPREDDIGWSLQLLAYISKYPNLKDSLQHTHLVIDISVRDKQLKLFIENQLKTKMKKDLAIKQRPTIKPKSRRSKSVSLRSGGETTPIINSGITQRDSANSRLSFTASASNSPQMINSLNSLRDDNFILDQDKLDLCDDDDTNVESGLRVDDTNVEGIQDDGCESDPEIGSVSESGSDNENFGNLLFPSFDQNKLSELYESILDSESIMDTLDREFALHELNEKISKCIERASQNLSTSITKKRLEQKQYLKQKWNYDTYENFNIDDQVNNQINELQNDPDYDDSLIEYKKVNLFPMVEKFTFLAGTDMYYWSGVVMRNSCRRNEHRGGVRQCGNLDCGKWETYPREFSKCRRCKRTKYCTRECQKKSWHCHRNWCIPSTSSTTNNANESQVAENDENEEPRTAQVQNILVNPSEVANDAETTGDNINNNNYGNDNDDGHQGTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7F0</accession>
    <name>G3B7F0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115720</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689003.1">
        <property type="nucleotide sequence ID" value="XM_006688940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7F0"/>
    <dbReference type="STRING" id="590646.G3B7F0"/>
    <dbReference type="GeneID" id="18247984"/>
    <dbReference type="KEGG" id="cten:18247984"/>
    <dbReference type="eggNOG" id="ENOG502QQFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_1_0_1"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="269" mass="30398" checksum="BE24927F05DF36D8" modified="2011-11-16" version="1">MLIEETFHDVKTSYGTTMRLFVYHPKIINYPRAKFPGVLVWSEIYQVTGPVSRFAKDIAGQGFIVVCPSIYHNFTNHQPLEYDVEGTDKGNEYKIKKPLKSYDEDSSLAIDYLLSLPTCNGKVGATGMCLGGHLAYRSALDPRVSATVCFFATDIHNHALGEGQQDDSLQRCGDITGEIIMIFGCKDNHVPLAGRDLIRSEMRKKNVEMTFIEINDAQHAFVRDELSKGRYDPATTKNCNEWLFELFNRKLKLEYGEHDGVAEKIDNVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7M4</accession>
    <name>G3B7M4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_124613</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687820.1">
        <property type="nucleotide sequence ID" value="XM_006687757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7M4"/>
    <dbReference type="GeneID" id="18249040"/>
    <dbReference type="KEGG" id="cten:18249040"/>
    <dbReference type="eggNOG" id="ENOG502QUA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020178_0_1_1"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="4">
        <location>
            <begin position="95"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="513" mass="58092" checksum="3D51008CD513B575" modified="2011-11-16" version="1">MSQIHDADSIDPIELSGYNVNDGIMKEPTTESNSNSSASSVAQYVPQVTEAPTTPELKRTPTLLQRVQSQVSFFNPRLKSHRFNLIKQFGTLYAVMLVCILGVFSIYWGASYGREGRLRNLRMLVVIEDEAVGGVEPVIGNTITSILHTPAVMARGDWRIQNITEFRAEAAKHNNTVQEEIFRQIHHQLYWSSIYVTKDATADYLKFIEGSNPSFNISTAIQSIYETGRDFVNMQSYVTPQIEYVEKQWLSRQNRLAGLFNSSESFTMEQVSRLSTPFRFEYLDHIPFTNPTLVAPSQVGLIYLIILTFFQVNMFSGIHQEMATIGMKNHHYLFYRLLSSSVSYFILSLGYSLVSLAFQVDFTVAFGKAGFLVYWMFSFITMMAVGFMNEVAFMILLMVFPPVAGFWLLFWVLINISSTFSPIALCPEFYRFGYAMPIHNSYELTKVVFFNTYKGQMGRNVGIIFAWIVIGMGSFSVVIPIFGKTMKKRAIAAKQKEAAAAAAKANENTKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8E3</accession>
    <name>G3B8E3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115837</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8E3"/>
    <dbReference type="STRING" id="590646.G3B8E3"/>
    <dbReference type="GeneID" id="18248045"/>
    <dbReference type="KEGG" id="cten:18248045"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_172_4_1"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="398" mass="46027" checksum="2919E5D23CFF8CE7" modified="2011-11-16" version="1">MTLDILPIIDDIHTSPYTPQLQRNCYTKTLDGLVINNFQFVKKLGSGTYGLIYLVKDLDTNRVYAAKIILKDQMNLNQKDIESYKKYIQERIFFEFINNYSNLQLEDLDLDLIKENGNQISYLKEISIHLKCHHHPNVVTIHKVISFSIGLVTVMDYYEQGDLFKNIVDNRIFSPSNPLMMKNCVLQIINVINYLSSKNIYHCDLKPENILVKYNPDYRRPDDAPIVDYNEISIGLIDFGLSMEDEIICCNSCRGSSFYMSPERLVNYTKNEYIKSIIDLSSYKTRPSTDSSPMLYFPTLKGDIWSIGVLLINITCARNPWPNSSIVPNNNEVFQTYAYEDTAILKKILPISTEFNVLLNKIFKLNPIERVDLQDLYNDVIVVDFFHDSMLTPPESPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8F1</accession>
    <name>G3B8F1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketopantoate reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_136308</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8F1"/>
    <dbReference type="GeneID" id="18249962"/>
    <dbReference type="KEGG" id="cten:18249962"/>
    <dbReference type="eggNOG" id="ENOG502QT3Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316416_0_0_1"/>
    <dbReference type="OrthoDB" id="5302359at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="209"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="848"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="894" mass="100713" checksum="70B2E74A2C579189" modified="2011-11-16" version="1">MSTNIQVLTVGSNPNLSFYAWRLQETNACRVTMVNSELNSRYPLEFTSNALGSAKFQPYNLVNHLNQLNPSDNFDIVFLSCTSLQDFQMVSSELVSFIHSNSIIFIESTGYINLEPFLNLSFGDSWNNLVIASVMNETDVRMLPSRGSNRFIHNIRNNDNRIYLGSSIEYNFNLNNHENFMKTFKLLQLVTEDSGNKLALLKSVVPKEFMTYQWKLALSRIVFSPLLVLFEISSPAELSSQILCKPLITGILNELLKIIKKMDCKLVKGYENEANLINYWSSLYTSHAGDVKVEYVNSPNLFYNYYHQFNLEIDLLLLQPILLGDDNGVRTPYLENLYSIICQLIKINDPESPSIFFQRIGHTNGHGPGMNGNGLAAKYEERDQVQQEIDERLNQLNLLTKNCGELEIRYNNLGSAIKEKEILKNQLSNDVDSKRSMISTLTANLDKQQSKFDEHQSNYNRLVKDIETLSLERDAKRQQAVNKSPINDANTSSRSTQDPIDQSNISHSTVQTTTRGSPSRTAYSSIPFNKTKGSTRDSVMTADNLTDLTDIAVYGAALNGEHFDPNSPNGSKQPTPRQGYQPVEKEANGSKQFQGHQQNFNQPQPVAPVPALAQYQGQPGQSQAVSASGPPPQPYQNMYNNNSPQGVHPQMNMNNINNMQMNQMNMNPMQMNQMNMNPMQMNQMNMNQMNQMNPRYAPGSKSRLNSLQSNGYYDNGMGMNPMQMQMMQNQMNQMQMMPQQMSNQMMPNAMSMQQMSYQQRPRAANRRSGFPAMDNPALIDMGGRGGMPMPGNKASRKSTSGIPISSGGYNVNGNSTRVDPETRHNKSMSTGNLVEQKLKLDQSQNLMLPQEHHDKQVQNDQPPGPAAKPLGAVSKTDDLHNHNISKKKKKGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8F3</accession>
    <name>G3B8F3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_107637</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit apl3 and beta-type subunit apl1), a medium chain (mu-type subunit apm4) and a small adaptin (sigma-type subunit aps2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8F3"/>
    <dbReference type="STRING" id="590646.G3B8F3"/>
    <dbReference type="GeneID" id="18245968"/>
    <dbReference type="KEGG" id="cten:18245968"/>
    <dbReference type="eggNOG" id="KOG0935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_3_2_1"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV62385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="145" mass="17347" checksum="2A729A2EFBFBE4E4" modified="2011-11-16" version="1">MSIHYVLILNRQGKTRLSRWYDKTYSRGAQNKSITEIHRLVSSRDSKHQSNFIEYQEKKLVYRRYAGLYFIMSIDINDSELAYLESLHFFVEILDVYFDNVCELDLVFNFYKLYAILDEVYLGGEIHEVSKSRILARLTELDRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8J4</accession>
    <name>G3B8J4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zf-C2HC5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_124822</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687918.1">
        <property type="nucleotide sequence ID" value="XM_006687855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8J4"/>
    <dbReference type="STRING" id="590646.G3B8J4"/>
    <dbReference type="GeneID" id="18249058"/>
    <dbReference type="KEGG" id="cten:18249058"/>
    <dbReference type="eggNOG" id="KOG2845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042447_0_0_1"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="3">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="493" mass="55901" checksum="91A445F6F87F958D" modified="2011-11-16" version="1">MISAKQKLELAGAIAEIIPLDPESCSQMVEYGLTLPNDSAIQDHFLNILGESDTTSAFLMKFIDVKNSLKHKPKVTPSPSSVIEPQPKRDSKNAWSTTKSRETSSSPAPIKPSKRVPITTSELIKEKQEETPKENRKSRKKKLESLQDLEAVLNSLEVKKDDDSRTVCFCNATRHPLFEIAPNCLNCGKIICAREGLQPCSFCGYELLSVKDRVEIKEVLLKEKQELDGKPVRPERYQGSPKPQTKPKKIVVSLKAGENLWKAQDAALKQAEAERKIQHERLEEEIASRETQSQQEKEISYYNNISGVDPDLVAAQQRLNTLLDFQDNGEERTKIIDNAADYEISTSNSGNMWLSAAERAIRLKKQQRQFRKYEENEQKRLGKGQKTVEMVIKDGKVTMVEKYSMRDDDDDEANTHEITKLEDDLKQSKRKDEDIATQNVWDYEADNNKWEKPVYVAGKAEVKVESQDFSDPLKKRVQFGSGGDSSELVASMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8L3</accession>
    <name>G3B8L3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cytosolic Fe-S cluster assembly factor nar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_109743</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8L3"/>
    <dbReference type="STRING" id="590646.G3B8L3"/>
    <dbReference type="GeneID" id="18246139"/>
    <dbReference type="KEGG" id="cten:18246139"/>
    <dbReference type="eggNOG" id="KOG2439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_0_1_1"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="7">
        <location>
            <begin position="103"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="532" mass="58776" checksum="B9F478B584DD3D4F" modified="2011-11-16" version="1">MSAILSADDLNDFITPGAACIKPPTQKENPNNGEVEVQIGMDGDPLEVSKIDGSTSNLSPAQISLADCLACSGCITSAEEILVAQHSHQELLKALNQRDTNTHFVASVSHQSRASLATALGVTVEQADRLLINLFVNQMGFQAVVGTSLGRKLSLISESYNIIHKKESNFEGPLLSSVCPGWVLYAEKTHPYILPKMSDIKSPQQITGCLLKNIMAEQLGTDKSNIYHLSIMPCFDKKLESARPEKGEEESTYKDVDCVLTAKELVTLLDQHPDTFKLIPDDVNDVIHSRVSIQEIYKQVAPVNWPLVEYAWSNDSGSASGGYSHNYLTIMKNHLMTKSPELVEDNFSIKTIYGKNTDIYELRLMYNDEKVASAAIVNGFRNIQNLVRRFKPSAPQKATAKVNPLVARRRARMSKPSGEGSIQEELADASKCDYVEVMACPNGCINGGGQISHPEDMLEKDWLLKAVENYQLIPLLSLDSEGVLASIVPDLISWSQAFTSKFDMPESRLFRTWFKEVEKPTDPNAILLGAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8T8</accession>
    <name>G3B8T8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall assembly and cell proliferation coordinating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_136363</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8T8"/>
    <dbReference type="STRING" id="590646.G3B8T8"/>
    <dbReference type="GeneID" id="18249966"/>
    <dbReference type="KEGG" id="cten:18249966"/>
    <dbReference type="eggNOG" id="ENOG502QTAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027501_0_0_1"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="2">
        <location>
            <begin position="99"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="486" mass="55056" checksum="620240A6E8875494" modified="2011-11-16" version="1">MKFGKKFQEFVYSLSTNDKYSEYDSTKSFNRINKPRTETETNLLSHNNGSTTFGTDHEEDSNFEKYKVDGVHEVRLAWRHIKNWVSKYSPDLNSSLQKACTDDDLSDFQKDLNIKLPNCVLEFYKLTDGQYSDDYDKVGGLFFGLKLMPLDDIMVMTEHWRKVAKKVTSEMSQLDTSGTLKQLPKLGNYRFSNSSIDLINVNDNPDASRISLQSVESDHKHKQTVSKYPSQKAIPPGCIHPIFAHPMWIPMITDDVGNCIGLDLAPPATGNGKWGQIILFGREFDTKFLVADNWGDFLLLFANDLEMGNWDISAPEKNNYGDLMIGNEGDLIYVDKETKKEMSYLTVLKKRCIAKWVESLDKDEMDSGVKKLVQDLKSNPDSILNIKNLNDNSIDEFINNNLNLVGGVIEPEMGEEPTEPKEPKALPEQPKTLPEEPKALPEIIQKLPKNLPAVPKASKSDNRQPSYSNSDVFAYSEGKTLEDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Y8</accession>
    <name>G3B8Y8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein rad10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115247</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Y8"/>
    <dbReference type="STRING" id="590646.G3B8Y8"/>
    <dbReference type="GeneID" id="18247792"/>
    <dbReference type="KEGG" id="cten:18247792"/>
    <dbReference type="eggNOG" id="KOG2841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041616_3_0_1"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="106"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="325" mass="36235" checksum="086D7E746F72B47D" modified="2011-11-16" version="1">MDPTSFASVLEGVKRMREQYADASDDGDDADSAPKRPQTDSPQPDQSLPSSATSASDATNTRITNTTLPTQPMVRSSLSPSPVGVGQSSRPVSRRIQPAVQMYSQIQVAPSQKGNPVFQSSLLKQKPIAYNKEILSDYYINPTLQVLFLSMKYHQLHPEYIWRRCKKLNQGSTVSTIKDNACKILLAVIDIESPQEALRKLNNICIKQDLTLLIAWSFEQAGNYIAMLKDNELSRTKVNLTIRGAKQSDFKSNLTDTLTSIRAINKTDVINLMTEIGSFKDIVEADNIKIHGFGDRKISNLKATFSQPFILNKEQTPDNEPERSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9A3</accession>
    <name>G3B9A3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_135779</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9A3"/>
    <dbReference type="GeneID" id="18249905"/>
    <dbReference type="KEGG" id="cten:18249905"/>
    <dbReference type="HOGENOM" id="CLU_663917_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="414" mass="46594" checksum="D0A9C94C63A524A2" modified="2011-11-16" version="1">MSIDLTNVIRSVESLGKMFRYSMGELQSGVLGGLERKLGEISRIVPGILRGQEQIRSDINRLCKYLQESDDVQAQRDERIRSLQLDIRSSLPVVVPESSLHHKYHHPQNLPASHESLAAKIDFIIQCVLVQRGTNIDWASKEIVSLVLRETGRMADGPRIERSTPRLEMLEKTQEIGASEPVTRIIVDGRATSVVAGSTRSAVASTEFSPNAQFSPQASNSSRDLSLIASSTPKTSPKLSPVNYNYKLAKKIKLPAMADMKLAKSLCVAMEPPPWHCTFNTSKIYSVEGLVNYWFLDDFMVDENAEPCVARKNLLYGWKWRKRFETSYFRKSCIIDFVLSIHHGTKKNNSRKNAPQSITCLRLRERPLLEIANWIDKCKDARCRGLTSFREFIAEDTDGLIIGLNTILDEAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9D4</accession>
    <name>G3B9D4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_108419</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9D4"/>
    <dbReference type="STRING" id="590646.G3B9D4"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_2_0_1"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="123"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="305" mass="34098" checksum="52FFBFD08847E43B" modified="2011-11-16" version="1">MSLITAGTLITMKLLKFVKLIMKIGVSLGGLVLAGLYSYQSKLIYPASINDGRGHCATPDEYNMPDYELVELKTKDGETLQGYSLKHDVKSPTYKNKTVLMLSPNAGNIGHALPIVSVFYLNFGYNVFIYSYRGYGKSTGQPSEKGLKVDAQTVVKYLREDKQFSNSSLILYGRSLGGAVTIYIAATMSDAVSGIILENTFLSIPKTVPHIFPFLKYAARFVHQVWDSESLVPKIPVRIPVLLLSARKDEIVPPNHMDRIFELLETDNKSLVKFPDSQHNDTVIQDGYWDKVQMFIKENINPVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9H3</accession>
    <name>G3B9H3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115335</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688865.1">
        <property type="nucleotide sequence ID" value="XM_006688802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9H3"/>
    <dbReference type="STRING" id="590646.G3B9H3"/>
    <dbReference type="GeneID" id="18247824"/>
    <dbReference type="KEGG" id="cten:18247824"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_1"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05262">
        <property type="entry name" value="SDR_a7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="299" mass="31896" checksum="094725FAF72D3B95" modified="2011-11-16" version="1">MKIFVTGGSGFIGSKVVEILISKGHSVIGLARSDASAEKLEAAGAEVVRGELTEIDLLIKTAAEADGTIHLGFLHDFTRFAYCMEMDQKIVTAICESYKGTNKFFINSTGTLGLQGPDLTDEDSPVPPPLLPGFSIRGETEKKLLAYAKEGVRVVSIRLSPTVHDVDCKGLIPSFYGMFKKAGAAYYPDAGDNVWPFVHRDDAAELYTLAVDKAAAGTVLHAIAEPGVSTKEIAEAMAKKGGLEAKSIPKAQLFEILGPLFGALYSANNHVSSEKTKKLTGWVPTGATFLEDFAASTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9H7</accession>
    <name>G3B9H7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115337</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9H7"/>
    <dbReference type="eggNOG" id="ENOG502QVA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031561_1_0_1"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="318" mass="36379" checksum="F5E5A9D6B39C0BFF" modified="2011-11-16" version="1">MINAFKPFMATISSSFSQAPAAHVHTVESLTRDVDIKPLHSHNDYWRQQPLFDALAHGCRSIESDIWKFKQNYQVTTAIATTTFYHDEAYVGHNQVFLRNNLTLNSLYLDPLFEFLQSTNPQISNIDPDVKHGVFFNSPETSLYLWMDIKLDANDTFEYLQPQLQRFIDQDYLSYYDSQSDTFVERPLTVILTGNLPSALVKAQPKVYTFLDAPLKDFKSMSNSQMVEVSKFSKVASASMTQLLGNEEFQTRPFSHEESVSLARFINIAHKYGMKTRIWGGVDWPKSLVYKHNMALIQMGCDLVNVNDLEFGSELVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9I0</accession>
    <name>G3B9I0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spindle pole body interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_108846</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688061.1">
        <property type="nucleotide sequence ID" value="XM_006687998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9I0"/>
    <dbReference type="STRING" id="590646.G3B9I0"/>
    <dbReference type="GeneID" id="18246067"/>
    <dbReference type="KEGG" id="cten:18246067"/>
    <dbReference type="eggNOG" id="ENOG502QQUZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009044_0_0_1"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000282">
        <property type="term" value="P:cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="1">
        <location>
            <begin position="5"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="631" mass="72267" checksum="760C12DF16EF8968" modified="2011-11-16" version="1">MKNIEFIVTAEFHVDKGPSLLHQIPVSLPGLANLVFLPELMIPDQIHKRSEDYTLFLLYRNSSTGEFQYLSDAKCEPDPYFLYTLVMNVKDESVKRGSVIKALAIITKLRYFKNFKPLLMIALDSYFGSSDMGVLQNLYNAINAKSFQVHEDDKDISIIKKLLITSILDLPINDKIYYDESFRRKLFDTEDFTNPDLFIRKDLSYNSVVTFNNMNIPIKIPMIDLPDNLDDYLNPTDINFKANLIQLLGSKLSTEYLNYELTIYGLSTPSIILMINAILTGKKVILLSYDKSSGYIIDFMLTILKIVTGGGILTGLLSNYNIFPIVDVSKIDIMEQCDSFLAGTINPFFKNNESLWDVLYDLDSNEILLSKNLDEGLNRQHFQNSIIGEDAKFLSNLQLSLFNYNDDLTTIQLIFRRHINEIIRILISSKNFHDTDIGLSVAKKDQKILLLQGIGYYWNNDTSKLIEVSCYQSIVRRFNSLLYSNRFSYNLGLQNLSNELNLMIDLQYHLQKLSGLSNVQEERTIWFNMLKYLISGKSLEIFLLVTFLVPPSSSSSLQKSSLHGGNITIFDKNKGIEFLLLNLFNGDNQVKGNIVMILQELSENFLCGWCLDNYLRSNMVYEMAYAELSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9T3</accession>
    <name>G3B9T3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_125360</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9T3"/>
    <dbReference type="STRING" id="590646.G3B9T3"/>
    <dbReference type="GeneID" id="18249100"/>
    <dbReference type="KEGG" id="cten:18249100"/>
    <dbReference type="eggNOG" id="KOG3836">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004311_0_0_1"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017020">
        <property type="term" value="F:myosin phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001280">
        <property type="term" value="P:positive regulation of unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001880">
        <property type="entry name" value="Mga2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF29">
        <property type="entry name" value="LD46604P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="538"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="770"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="868"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="919"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1108" mass="123446" checksum="90CDBB32FAEBFB8F" modified="2011-11-16" version="1">MAFSFADDSLLNSKFFEGDISSSNNVNQSDDILDEFLDQRVYDNVGLSPDKSEFFEFYENSPSVIAVHQGQGTVSNHNYNESLSPMNEGDGGEVHSVLSNVSSHVNVEHLNHLSETNSTPNLNSHTNNNNNSFFDSLNPSPSMSTGLSSDNGDMSQYELLRNQVSKLKFGKYEMKVTPDSIEPTVDLLDFSPEAMSKLPYSLSLLGLPDYSRVETQIKINFNMNPPPPQNLLHIPQDLVSKNKFCLSDELSSLSPIILKNLLYLDCFVLTSDMTKSCNVCPKCIKREQKRASRRRLGIDDAPELPRISPHGIVKNNPSAWLDDKMLKKAIMFNCKEIVSFPAPNSLNNNKALELSARIICYCRHHQESEGFKLLFVVRNYEGDVLAKSVSSNIMIMDRKKPMSGGISHRSSSSITGYANESSSSFTKPLTQKNPTSPGIKSEPRTDEDLKHPISPNSIDESSDLTTNESERNLKRKKLSIDDSNNSTNPMYNGSVNGFSPVSNSDTNTSINNHQLNKNVYQRTPSRIPDNINSNLTTLPTILRIIPAEGPIRGGIEVTLLGFNFNSNLGVKFGANSALATHCWSETTIVTYLPPAAQPGQVLVSFENHENLLTNQQQQIFTYTDDTDKQLIELALQIVGLKMNGKLEDAKNIAKRIVGNDNSNNISSSNSNVNSAGISPSVTNNSGALEWYNNAQGIVEKLTQMNYSTEEILVNFLKLVELPNCPIIIPNWQLANNEGQTLLHLSTLKNYTMLVKFLTNHGCKIDLQDNQGLTPLFYASINGQRELIDLFINCKANPHLRLSNDKTIKDYCDLNVMDMFSDIENGMEDGSSINEGLQKSYSMDSLNSMFEMKGLHVSKMVPERLEDDSEFADSEYSGDCDVSDYNDDVSNYDDDISEVNDDLGIQASNSNIPTISYIVESESEDAKTIKDGTSEGNDTDRPPSPEPSSGAGGIWQKVKNVFNNSDDDLPNYDDLFPFGPSVGPFRPKSTIERLLNNQQDKEIEVQQESSSTSIKEAEIETKEDLSDSSEDMIISYINHPRKTVENDKMLIFFWVPVLLIIVSLFISVSVIGYEFEPIDNFKQLIREGLGNLMVGNERIKRVFSDSVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9U8</accession>
    <name>G3B9U8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115429</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9U8"/>
    <dbReference type="STRING" id="590646.G3B9U8"/>
    <dbReference type="GeneID" id="18247866"/>
    <dbReference type="KEGG" id="cten:18247866"/>
    <dbReference type="eggNOG" id="KOG3162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082177_1_0_1"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="203" mass="22784" checksum="514D7BF9A036FC08" modified="2011-11-16" version="1">MFNLTASSRKIVTRASVSISTPHLASSRWFGISHVASQNKPLPSTPEMKDEKWNLNVEGSSAEGSTKIASTVLNMTNLLNDQRDPPLDIDDYFIKKFKPFDNYDPFDLSMKQIEIDQRARKYPKNKKSRDPFARSGINPLDLYTMPLILSRFLTSTGQILPATITGCNPRNQKKLGIAIKRARACGLLSSVHKDVSYLPSRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA27</accession>
    <name>G3BA27_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_99098</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688165.1">
        <property type="nucleotide sequence ID" value="XM_006688102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA27"/>
    <dbReference type="STRING" id="590646.G3BA27"/>
    <dbReference type="GeneID" id="18250826"/>
    <dbReference type="KEGG" id="cten:18250826"/>
    <dbReference type="eggNOG" id="ENOG502SDEG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112987_0_0_1"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="148" mass="16252" checksum="01F0A481BA2A3C9B" modified="2011-11-16" version="1">MFRSTVSKLYRQPTRSLHYSRPTYSVVSGVKETLEKANKKTGEFLAATMETAEKTPETVGDVAEKVNKKTGKVLAEGMEKVQRVAPNNLSEAADKANKKTGEVLADGVEKVNAGEHLDRVRENAKGYKNLQDKGSKAESEQNRPEDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAL1</accession>
    <name>G3BAL1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCA-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_114906</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573</strain>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded. The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA. This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="7"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAL1"/>
    <dbReference type="STRING" id="590646.G3BAL1"/>
    <dbReference type="GeneID" id="18247629"/>
    <dbReference type="KEGG" id="cten:18247629"/>
    <dbReference type="eggNOG" id="KOG2159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019592_2_1_1"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="14">
        <location>
            <begin position="42"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="15">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV62524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="536" mass="60604" checksum="E3D4E4F07D5F7AA6" modified="2011-11-16" version="1">MKRTINNSIVLNETEVNIKNLLLEFCNQYNSTIQDRTRHLVLRITGGWVRDKLLGDESHDLDVAINHMSGEEFASKLSLYLTKHHPDLPLSSVYKIKSNPEKSKHLETCTTKIYDLDIDFVNLRSEKYTSESRIPVIEYGTAQEDALRRDATLNALFYNLNESKIEDFTNRGLQDLQDGILRTPLKPLQTFLDDPLRVLRLVRFASRYNFTVETETLTAMKDPEINASLLHKISRERVGVELDKILTSANPEYGLRLLNYVNITESVFNVGTISSQLSKFNSTNEIEQYGRLSQQLGPQVSAATAVFPVFKSILLGSDNHRLIGSFNTVSSKHLWLSVVLYPFRSMSLRINDKMSGIYHVPEIIIKEGLRFGKHDFEPVSNVLANLGSSSEIWANTVAGTIARSRLGLYLRQFGIYGDVNILVNCFLEALQQVQHLLKPSHDEPTPQPPVLNDPDINDALTATISKYERILGAIEEQDLTLVHSLKPLVDGKTISKALDKKSGPWMAPVIQEVLVWQLDNPQGTPEQCLEHLKRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAU5</accession>
    <name>G3BAU5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_131530</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAU5"/>
    <dbReference type="STRING" id="590646.G3BAU5"/>
    <dbReference type="eggNOG" id="KOG0468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="132"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="972" mass="109144" checksum="53DEF91B3C8C2828" modified="2011-11-16" version="1">MAANFIYDEFGNLIGGEDSDSDNLSDISGDEEEVKDDDDEEEEPNESQQAQLVSYKNNANGLTLSQRFGPEVTTVVAHTEDSMSEPVIRPARERTGKIEVTISDDTDPYTDSSHRVRYSLDYMVNLMYQLPERIRNIALVGNLHSGKTSFVDMLVLQTHETLTRKQSKNFEQLKFTDNHILEIKRGMSIKAAPITLLLPDTNGKSYIFNILDSPGHMNFMDETIASLEASDGAVIVLDVVEGLTFADKFVIDEIMKRNLKFSLVLNKIDRLILELRLPVSDAYYKLQYIIDNINNYISNSEYSASYAYDPILSPERNNVTFASSTLQFCFNLNSFVQLYFDAKDITTIDKEVFARRLWGNNYYNPESHKFTKDSKGGSLSRTFIHFILEPIYKIITYTITRDSNSELLPTLLKDNFGISFTAKQLKNNSQMLLPEIFLAIFPSGNGFVNMVTNSIYSPAEAIKPVSVVFQEPVSQDKVIAHIVKLIESSDGESFSALVRIHQGTLKVGDQVNVISDTFKTETEVHLQTVSEIHIPGGRYKVPVNEASEGFLVIVKGIETSINKHGYIFDKSIGVSDIKDTKFIDYTSESVLKVAVEPKNPSELPRLVESLKKLNKGYLSSVVKLEESGEYVVFGTGEVILDCMLHDIRNFYEDGLEIRVSDPMVKFSETVTEMSVTKISSTIGDISMSIIAEPINNEALSKALEAGKIDLNQPIKTVSRQLRNDFGVDSLEARSVWSYGPHDHKQPSILVDDTLEAETDKKALYTIKQAIEMGFQWSCSEGPLCDEPIRNTKFKILDIDFNDTADIQTNTAQIIPLTRRACYTGFLTASPRLMEPVYKVLVTCSSRANHLIAKLLNGRRGKIHTNDAIPGTQLFQLEGIVPVIESIGFETELRLQTQGQAMCLMKFDGYSMAPGNPLDDEVYLPELKPVPMESIARDFVLKTRRRKGLTGEASLHKYIDPELYEKLKSIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAV7</accession>
    <name>G3BAV7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fcf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114926</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAV7"/>
    <dbReference type="STRING" id="590646.G3BAV7"/>
    <dbReference type="GeneID" id="18247637"/>
    <dbReference type="KEGG" id="cten:18247637"/>
    <dbReference type="eggNOG" id="KOG3165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081098_0_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="59"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="185" mass="20974" checksum="83EF80D4808F3D9A" modified="2011-11-16" version="1">MGKAKKTRKFAAVKRVINAKDIKKSVSKPQKSDPELTRSVPQVSSALFFQYNQSIKPPYQILIDTNFINFSIQKKIDIIHGLMECTMAKCIPIITDCVMAELEKLGPKYRIALKLAKDPRIQRLTCSHKGIYADDCIVNRVMQHKCFVVATNDADLKRRIRKIPGIPIMGVGARAYVIERLPDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBK5</accession>
    <name>G3BBK5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gem-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94450</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687731.1">
        <property type="nucleotide sequence ID" value="XM_006687668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBK5"/>
    <dbReference type="STRING" id="590646.G3BBK5"/>
    <dbReference type="GeneID" id="18250399"/>
    <dbReference type="KEGG" id="cten:18250399"/>
    <dbReference type="eggNOG" id="ENOG502SCAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083380_0_0_1"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28418" checksum="A932057942663B94" modified="2011-11-16" version="1">MKRRLQERDSSRDKSANEVIPVEYEEVIEGIPVQKSAVYEYLASVRQEAETVSYMTPTEVASDSTSEKLYQSDSSTEFYINTNIGNVQLEEPLEKWKNVFLKDFRRTKSQIDSDLSLERSSHPPWEQPESASLWRKYVIDNPPPAFEVIQYQFDHITAMRLLVHLTSWLSNKTNDNLSQWIYCLLLRTDSVLEYSDCAIIRGLGKKAVKLLQKSENDAAVSSTAKYTFEFIVLLVCHYYHQKDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC37</accession>
    <name>G3BC37_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_111570</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC37"/>
    <dbReference type="GeneID" id="18246296"/>
    <dbReference type="KEGG" id="cten:18246296"/>
    <dbReference type="eggNOG" id="ENOG502QREF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008074_1_1_1"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="378"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="740" mass="85896" checksum="BC227187BDD8C114" modified="2011-11-16" version="1">MFSAASLKRQYSDLRVIGDRLRLQQSVSIKLHRWYSDFLHNEYDFDQDPRFNAHVEKLLEKHQSDPELWSLTKRVADLPLSVTIPEYFNPMTSSPKPIMQPFDPRFTLSVYFQWMKHHVNEPVVFHWSDWVDLSKLTPLVFNNGQINKCEDMFDISGNEELIRDSEIRHINDYCHNYFATTLGYKITSAAGPQTIENNELIGKSFLYTTFEPPTKLVLMNDDGLYEVPVSNRNNNMKYSLLNNKYVEKLKLSGPVEVTSSYKAMVKAWGTPTIQLPPVKKEVKLDKTMFMFDAKDKIKQLRAVKKRTLNQDMYLNSLEVSIKEGEPPKYFHEAKLLQSYKEHWLGEHYDWRFFNGLTVGKGEQMISLCKLIKAYLDLCITEGLVTWIAHGSLLSWYWNGSIFPWDTDLDVQMPIAELNKLAERFNQSLVVENVMKNGQFSGMGKYFVDVGSSITYREKGNGNNNIDGRFIDTDTGLYVDITALAITNTLAPTQYDSLPAPEFAEVTGQENFHLNLKHGLANCRNDHFVKVDEVNLLKPIHFQDQTSYLSTNFLIMINNEYELSSMTEKNYRDYIYLKNFRIWVNTQNILDYMKNSDEWVAQQNGQVQAREDVGESSSEVEGEGDENEKRVVGALEKLQINKLGYNDYFNLLEDKTILKDYLINRNNSANHQEELDKLMYSRDTGDSSKFLENNFIMDLFINRIYETGWNYDQEVNKMVGLSQLMNKPERAITGRSTGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC59</accession>
    <name>G3BC59_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin biosynthesis protein CHS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_111729</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC59"/>
    <dbReference type="STRING" id="590646.G3BC59"/>
    <dbReference type="eggNOG" id="KOG1181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019904_3_2_1"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000077">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="77"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="164"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="455" mass="50287" checksum="9D7B8F0E207AF473" modified="2011-11-16" version="1">MVEVSLTVGKLDASLALLLTKDHHLIEFPTILLPTGVKAGSIVSIKCEQDSQTEKEEAKQFKAIQDEILNTFGKNLPKSPVLRIKNVTQTSCVLEWEQLDLGTATLKNLFLFKDGKKVGAIPQPLTNRTTKLSGLPIDKTFEFQLRLDTTAGVYVSEVLEVTTHKMTDLTGITVCLGDISANEQFTVEDIEKTLETIGARVPAQTKISVDTTHFICTRENKQNSEYTKAGEMNIPIIRPEWLKACEREKRIVGVRDYYVKDCSLPDIFARNFWNKETKDGLVEKQHDPLPEPPKETDAVPDTEAVPDTEAVPDTEAVPDTEAVTDKETVLEEVPETIAETVAEHPETEKEAPEVVKELVEEPKEPVEEPKEPIEHPVATPEAAEVSVSQPVKVTVEETPDTPEVAAPETPELPQEAPEIAPDTDDTDDIAPNDASPPTASPSKKPKKKKNKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCG4</accession>
    <name>G3BCG4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rrn9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_137302</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690044.1">
        <property type="nucleotide sequence ID" value="XM_006689981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCG4"/>
    <dbReference type="GeneID" id="18250051"/>
    <dbReference type="KEGG" id="cten:18250051"/>
    <dbReference type="eggNOG" id="ENOG502T2HP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665675_0_0_1"/>
    <dbReference type="OrthoDB" id="4068335at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="53833" checksum="6BA1322087945D80" modified="2011-11-16" version="1">MPETDISEYRRLLGSLEKSHRRDLATHLYSTALMHNLHPVFPYWRYTQWPLSVDRVPDPRTQFEYTDVANIRGIRFEPEVVQSAVEARFTRFTPNNLATEPVLPITRGSRKLRHGQTDAPPSRKRPVREVDSDDSSESEYFSAGADGGSEEESDGEVEELDWLDDEKGDENGDENGVEPNNNDSDEDETIGTLRVSDASDTDAEEESDSINPLRRIKFVQKRSDHNADLYLEMKALLERAISKKLNRMNLRKGQQMTTKMDTPATDQMAKCLAGKVDDLTRELAKLSHKDDTNPHRHGLFTWQDILISEQLIAKPTLPSTGSNEFYTKCEDMFLHMKYNYRLAGESENEEEDAPTNSSVNFSYYDYLQRLQHKKVTKKSNMTPEFILQQKQAVKEVAANKRKIFMELLAQKERDNTLSWNKGYNRDGVYKKGKRHFKAPKNDEEFPEFALQHGGLRIDEYEYLVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCM8</accession>
    <name>G3BCM8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_116259</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCM8"/>
    <dbReference type="STRING" id="590646.G3BCM8"/>
    <dbReference type="GeneID" id="18248219"/>
    <dbReference type="KEGG" id="cten:18248219"/>
    <dbReference type="eggNOG" id="KOG3914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022082_0_0_1"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="418" mass="47432" checksum="32FE6A3DA2C4B140" modified="2011-11-16" version="1">MKHPFQNIEATSTHLFATVKNSLQVFSLNDGILVGEWLDTVDSQQNLVKQHQAKFEQLQKQEDIKSSSEEPETKRAESNSKTKIPKFPTPGPGAPPIYNYIRCLELTSDEKYLIGTTDSDKSIIIFELDFNSANCLKLVKRQVFPKRPCSISVADNNTTAVVGDKFGDVYKIPIDCEPPIDEKLLKPILGHVSMLTDVLVGENEGRQYILTSDRDEHIKVSHYPQTFVVKHWLFGHDEFISSMIFPSFDKTLLVTGGGDDSIYLWDWIHNKALASFNLRSLVEAYLNESHYPPERFRTETSVKEICVVKIVSSGRKIFVLLENVTCVLYFTINEDLTFSIDKVLDVPHPLVDLTISENQLIGASDSENILTFINIDPFEVVHNEISSKIAVLNPCDVSSRDDFYPLYAMNNLRKRSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCN4</accession>
    <name>G3BCN4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIP120-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_137310</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCN4"/>
    <dbReference type="STRING" id="590646.G3BCN4"/>
    <dbReference type="GeneID" id="18250052"/>
    <dbReference type="KEGG" id="cten:18250052"/>
    <dbReference type="eggNOG" id="KOG1824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_265739_0_0_1"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="833"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1007" mass="115991" checksum="CD122D981BDD47F5" modified="2011-11-16" version="1">MLLPQLTKPDIGNDMIEILIELIKNFGPEFKFEESLKLSNYLINLSFAQVSNSIGKKAIFALDLLLSNKFDIDTEIFDSLLTCINLDYDKSNKSFKYTYNKLELTLTLVKNLDNLNIPLTTSIVEELFNQVQYHLNFEPEDLDYDQIQEDNLIKEVSLDILINIVNYNLSVTYVIEKFIDYNPMKSEDDSDFDVENEEDEVEFSDDDELENQQEDFDDGSWKLRLKSIVLISKLKDTNYLPKLIEKIGDKNEFIFKYSVSTINSLLISGSVDLIPSIESQIIANISNENLLTFLSLIETILSRDLTLSDDFVQNFLNYLENNIKNFELIEVLGSLNLIISNMSFHLLNSISEKLVPTLCGLLAKNSNLVFMDLKILNQLLARLDSERNETIFRSIIEKLSDSKLLIDLKIELLNSLNVYILNNQIDSEEKIQLIVAIYEQNLNSELMIKSNLSNLNQIFDKSLNPNVAKFSSNKSFETILINTLKLYLNSNPNSKSVYYSILHLFKKLDYSLNTDELLDFGISHSNDVKIVNLIFDNLSSITFSQEELEHSVKFINSIEDLEDPELVLLDGFVANVCSQGNFYNQFEASLDLNKLISIKAMALITIKLGLTEKIQNSQTKMNEMIINKAFNKDFNQILQYLSFINLNYDLEHINLKQLISLLNFEDIDGATKFEISKCLGYLTKTTPHLLIEKFNNNDDLIKVQLLNSIKYYLKNFSNQEFEAQIWKLLLDEVNVPSIKKEFKLIGEILSIIAIKNEEFGEVLNILKLENQSIGLIFANLIIVNHLIVNLNGHAELINEFILLSLKFFDITNIELKIILVKNLINVYYNYSVLLNENISLILPKLFDELKAYDEFKKIIPMGPYKYVIDQGLEIRKLIFELLYSIIGDASISKDLDYLTNEIVAKGLTDKEFDVVNLSYTSLLKLIHLNIEYLNNFSNVDGLINNLTVNLNKKLKTKATSQEIEIFQESQKNLVNLSNKINDVLSKYNWSYNNWDVYYNAVKKLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCN8</accession>
    <name>G3BCN8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Found in mitochondrial proteome protein 38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_96285</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCN8"/>
    <dbReference type="STRING" id="590646.G3BCN8"/>
    <dbReference type="GeneID" id="18250597"/>
    <dbReference type="KEGG" id="cten:18250597"/>
    <dbReference type="eggNOG" id="ENOG502S067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025792_0_0_1"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="226"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="521" mass="59407" checksum="F992BF8E1DE45D52" modified="2011-11-16" version="1">MLTRLLYIRTPHVFRRSASVLSNLVSKCSSCGIQLQSTSAAAPGYIPLVSHKPFQRQEDTIYNKYTKHLDPEDMALLNLHPTAAESQHPRHKHTSDSSYKDCLRCRQIKHKHQFNSVEETQNLSTTSIIDKVEHINGQMVYAISAIDFPLGINKQLVNQYKPIVVITKCDLIFPQKETMAKFPFYKEYMTAKFEIPPTNVFLVSSRRDWGLQTLNSVLQSNPQKYFIVGDINSGKSSLISKLLLRDRGDTRMKYDVWAARNGPGISNLPGFTRGELQFSISNYELIDLPGLNHMNFPNFARLKNVFKAPPLYRKGLYSSQYDTIKGGQVLAVGGFFYVKLPDNGMILQYKNLINVSPVVLRDTDRIGALEQKLDPSLTNKFLIPPTTKLRKLLIPPFVGKIDLVVKNLGYLELTPTGSKSDNKLIEVLVPENLDLQIIVRKPLVTYVQKVLSGRNKNGNVLSLPNLWKSTKVVQHYRNEKLYSRLYPFLQSQQQSIEALSGMQYAEDTEITRENYDAYWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCP4</accession>
    <name>G3BCP4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_137317</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690059.1">
        <property type="nucleotide sequence ID" value="XM_006689996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCP4"/>
    <dbReference type="STRING" id="590646.G3BCP4"/>
    <dbReference type="GeneID" id="18250053"/>
    <dbReference type="KEGG" id="cten:18250053"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076142_0_1_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF243">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="200" mass="23101" checksum="B76AB3AD1F6124A7" modified="2011-11-16" version="1">MSTYEDDHNISSSRPQEDNERTRTHQSLSSIIDSFVTSNHSHIESLPETQESQIETFRNALQVLSAEEGSTLATDLIGVLEDQDFNPKKGLPDDYLDTLDRVSLKDLTPEDDCPICTNRFVEDKYPLIVKLPCNAKTKHRGHIFDLECIGPWLKMNATCPLCRFDLSELNQKRKERLAEELRLIKEQEEEEEEEDWDVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD90</accession>
    <name>G3BD90_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_111872</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690290.1">
        <property type="nucleotide sequence ID" value="XM_006690227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD90"/>
    <dbReference type="GeneID" id="18246320"/>
    <dbReference type="KEGG" id="cten:18246320"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF24">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="529" mass="60170" checksum="9CE8AAE9162F64BC" modified="2011-11-16" version="1">MSASSIDKQPHYTEDAPINLEDDRVENYIKQDLKWWKQSHLIKLNFLLFLCTLASTNNGYDGSMLNGLQSLESWNKKINPSGDSVKLGALSNGTIFGSIIGLPIVPYIVDRWGRRVGIFSGQLLCLIGAILQGVSTNYAFFLSARMVLGLGNAFMVVSAPALISEIAFPSHREAATGFYNTCWYLGAFLAAWITYGTNKLGTENNWAWRIPSFLQGFMPLVQVLTIFFVPESPRFHVSKGQFDKAEAMLRKHHIGGSNDPMDLALIDFEMKEIQLAIELEKLNTESSYWDFIKLKNFRKRTFLVFYTPCIMQLSGNGLVSYYLNKVLNSIGITDSDRQLQINGFLMMYNMFLSMGVAFVFKYFKRRKMFLFSIASMLICYILWTILSALAVKRHYPTSLSNGVLAFIFLFYASYDIGLNGLPILYITEILPYTHRAKGLNLFQFGQTCTLIFNGYVNPVAMDAIEWKYYIVWCCNLAVELVVVYFFYPETNLHKDTTLEEIGQIFGDPISDSRLMSISHEEKLEVEHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDA8</accession>
    <name>G3BDA8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_111614</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDA8"/>
    <dbReference type="STRING" id="590646.G3BDA8"/>
    <dbReference type="GeneID" id="18246301"/>
    <dbReference type="KEGG" id="cten:18246301"/>
    <dbReference type="eggNOG" id="ENOG502QQTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005663_0_0_1"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="872" mass="99380" checksum="627727E48E77A050" modified="2011-11-16" version="1">MDSPEKGYSDISRSSQSPQDDSDRSKTKFRRNYRACLNCRLRKVKCDLGSVDNPVEGKCARCRRERKDCVFVESKRGGTKVQVAQQRFLKSDSLEKNSRPGAYEPPSSLPSVSNILNHNMAIPQTVSRQQSNGPEPSPSTYRDPSSRKEEGHFSTMEGALVYLAKAAGTIAKADERDNIDAGKRHQQLEDDMHNKPVDNKYRKLIADDEESQIKVPKHIQDQSNYLSIPITDEFSIRPKGGNKLSSIDYIGENGLLTEFEAEMLVNLFFTTMHPYFPHIPNFLHKPQVLAGYPILLCAILTISSRYHSLDANPNNTTTGNVNGVPRNIEIHDKLWLYVQRLISQTVWAEASTRSVGTVFAFLLLTEWNPRAIHWRWTDYANRPEDKNQAEERPRQDQNLAGLGAVRRSYRMAWMLIGSAVRLAQDMGFMEVSPKTFLATHISEINSVMNISRRSMLSHSLSELEIDEDVNMDDLDEDTDYDYDHTIQNMTEEEIKGKSREPIRFSFRQRAKIELLQIMSLSHESLYGYKAQLGSLTQRQNLAVLNIISPLINNWENKYKRLMKPSNYRQYNLNNTNLLLDQTSKLARELYDCIEHECSIFEFNYAKLYVFSLALSSSSDSKPDNTGRKNSRQRVNLKLDEISKSAKYIEQAFLAANEMLAVAHRVHKLKMLRFMPVRWVTRIVRAVAFIVKCYLTITAHKKSTSGPEANVANSTNFDAMILSLSLIPVDEIMTSIQRAAITLRDCSPDELHLCTRYSNVLMYLCSEMKTTSKGPSDSYVQPDLNLYRGFDGEGITSELPVNLQTSNPQTSNPTTNVDMEAETPLQNLMGDSEVMDWFITNKNVGLDFVGPWTEMIEQQLNSNDQFNFDDAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDC7</accession>
    <name>G3BDC7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese and iron superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_100221</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690142.1">
        <property type="nucleotide sequence ID" value="XM_006690079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDC7"/>
    <dbReference type="STRING" id="590646.G3BDC7"/>
    <dbReference type="GeneID" id="18245370"/>
    <dbReference type="KEGG" id="cten:18245370"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057349_1_1_1"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="259" mass="29463" checksum="15FB237E90A3DC9F" modified="2011-11-16" version="1">MFSRITSASIRSIVRCQRSVHTVPQLKNQDVFLKNGIEGLYTPKGFEASWLQYQKYLTMNLTLLTNGTEGESRPPYQILLNTARQTLGQHTFHFASQAHNNHLMFEQLTNASEAQQSQPSRYLLGRLADAGYNNIEEFRDAFLSVAELSIGQGWVFLVEDADKSVRILRCNNDGTPYYYGKNQSLDLNGGVNEGNFEQLNLIKEAGTSNKRDFTLPILGISFWDTSYINDYGVNGKKEYLQSVWKCIDWNVVNGRLLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDY5</accession>
    <name>G3BDY5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116461</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690351.1">
        <property type="nucleotide sequence ID" value="XM_006690288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDY5"/>
    <dbReference type="STRING" id="590646.G3BDY5"/>
    <dbReference type="GeneID" id="18248320"/>
    <dbReference type="KEGG" id="cten:18248320"/>
    <dbReference type="eggNOG" id="KOG3157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_2_0_1"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="24"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="249" mass="27752" checksum="90D219F7E31EAB84" modified="2011-11-16" version="1">MSVTLPALVRQKELISNYDIILNKVKEVALRAASAQVELVAVSKLKPSSDILTLYNHGVRHFGENYVQELTTKASELPKDIKWHFIGSLQTDKCKVLAKNIENLHAVETIDSLKKCKKLNTHRQEVNGAVINVYLQINTSGEDQKSGFKLSEGGKKDLYEAVSFLVSEECKFLSFEGLMTIGSFLESTSSEQNNDFKKLVDLKKELDEKFSLSLKTSMGMSNDFQDAIRQGSTSVRVGSSIFGTRPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE10</accession>
    <name>G3BE10_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_136915</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE10"/>
    <dbReference type="STRING" id="590646.G3BE10"/>
    <dbReference type="eggNOG" id="ENOG502RIXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582651_0_0_1"/>
    <dbReference type="OrthoDB" id="4077024at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="6">
        <location>
            <begin position="347"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="469" mass="52348" checksum="A5437C93BADBE633" modified="2011-11-16" version="1">MENWESDHNHEYESVLHYEIFTDSEPNYKVTLEEQSKEETSSKSQNKETGVHPNLTTDLKIPTTVTTQESSSDNEHTTNQSFILAGNTDVLFGSPESVVASDNFIQDNPFIEPLKEANQPTRSFSYLERILASQATRNSSAVTQIVNDKLLANASLPDKFKSSNHGDTKVSFISPEKGLESTQRSPSVSTAINDEIPMEELAVLSNNEEESQSGSPSVFVPQEDDISDHSEMIQINSPTFSPTQPESFEDDIPVEGDNHSAGFPGDSSDDHDMFGYTPLDQVHKFDNDILPRIDDTSIIDKPYLVSRVSGKTNSENSNGLDSDYGLSRKTIKSLLGSLTLENNKKRKRLKSTSEALGLVQQQSETFLTNLTSDLEVYARHRGGTEITIRDVMLFIRRLKYPTVNGARANNVNYFSELAGKHLPLESLMELNNCLKNTYYTNMVEVDDQDLDDSDINEDPSIENFTDDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE27</accession>
    <name>G3BE27_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116489</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE27"/>
    <dbReference type="STRING" id="590646.G3BE27"/>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048591_0_0_1"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="205"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="430" mass="50707" checksum="C51E67BC74A58C7E" modified="2011-11-16" version="1">MEDQLDAIIFDTIVPLPYRILFLIQLGHLLWYLIVYGCYNINGINVLQLINLSYSSHNYPQLGESPAVGEQATISVADPKENSLLLKGIWFNLRVISINTMVSFIIFKIIQILFSDETHHVTLVLIYHLIPLVTMLIISYKIFSKPSDKSVGKLRLSTTMKRILSGNINSKSMRTNDILISDSLVSYSKVLNDIGIFIWHYFVSDELPYNSFLELFVLCLPALIRIRQCWQEFLLTRQRSHMLNLMKYTTGIAPIFINFLIKFNVQEYGEDNDAGKEMHLHLLKILNVWWYLCSFINSTYSFIWDVRMDWGFETFDYFLKKSSFTLRSPDKLIYRKPIIYYSGITVDFLLRYIWVLKFYTQREAEDKPIITRVGLFLFGYDAFSFGYSLIEVLEIFRRFMWCFFKLENDWFKLDPQYTTLTNNVELMKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEE4</accession>
    <name>G3BEE4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="12">1.5.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_116594</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573</strain>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.15" evidence="12"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEE4"/>
    <dbReference type="STRING" id="590646.G3BEE4"/>
    <dbReference type="eggNOG" id="KOG0089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031413_0_0_1"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000255">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000012">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="14">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="15">
        <location>
            <begin position="154"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="320" mass="35688" checksum="15C66B8F45F62853" modified="2011-11-16" version="1">MSDVPVQPQPKKPAGRTILASTIAKIYTSEIADKVKSLGYAPKIVGLLANGDPAALMYANWTSKTCNELGFDYELVHCDKQQLENKLIKANQDNSINGIMVYFPVFGDNQDQYLQQLISPEKDVEGLNYLYYKNLYHNIRFLDPPTNRKKSILPCTPLAIVKILEYLGIYNKILPYGNRLYGKKIMVVNRSEIVGRPLAALLANDGATVYSVDINNIQQFTRGDDLSEQKHKVIDLDSATASIDNLAPTCDVIITGVPSDHYKFDSQLVTNGTTIVNFSSARNFNDDIKLKAALYVPSIGKVTIAMLLRNLLRLIENNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEV9</accession>
    <name>G3BEV9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMK killer toxin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116681</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEV9"/>
    <dbReference type="STRING" id="590646.G3BEV9"/>
    <dbReference type="GeneID" id="18248401"/>
    <dbReference type="KEGG" id="cten:18248401"/>
    <dbReference type="eggNOG" id="ENOG502S6V3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068499_1_0_1"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="123" mass="13691" checksum="0732FB540C3F13A9" modified="2011-11-16" version="1">MSFITELWESVFTPGTTPALIKATHGSFIMLILSLCSLVFMTRSIHFVNLLVISILLYASVVWFIHELNQAKLKDNLELEKEVEEDTTSSEKEVSKVEDAKSSEKSSTSATAKPSASPKKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF18</accession>
    <name>G3BF18_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116016</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690188.1">
        <property type="nucleotide sequence ID" value="XM_006690125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF18"/>
    <dbReference type="STRING" id="590646.G3BF18"/>
    <dbReference type="GeneID" id="18248126"/>
    <dbReference type="KEGG" id="cten:18248126"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047858_0_0_1"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="263"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="363" mass="41980" checksum="DEEFF39B7D923AE1" modified="2011-11-16" version="1">MSNVKQEIKQEDNGDKVDEPELMSDPEDYLEKGESLDMDLTNGNQKIWLVKLPKYLATKWQNPNLMGKQLGRVKIRNTTANGHKKLEVKLVVDDSTANDEIPQEYDISILNTQVRNSYVFSEENLQRFKAENTELSSDRPIEKTPEVEEDYRQRRYNRFGNGQNQNQNPDAVPFVKTIPKKTALCGKICHDCQIRPSITDKRAKDYAARKHTIQKEKVRPKVVLLDEIPGVSQSNAGPSFKGRGTNVFLKPNTNKNKNEGRAIRMPQKDLLDLLFRLFEEYEYWSIKGLRERTKQPESYLKESLDSIANLIKKGPYTSKYNLKPEYKKLRDAERAAKAGLDINHNDNNDQEEEEEDDDMEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF91</accession>
    <name>G3BF91_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_126750</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573</strain>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF91"/>
    <dbReference type="STRING" id="590646.G3BF91"/>
    <dbReference type="GeneID" id="18249194"/>
    <dbReference type="KEGG" id="cten:18249194"/>
    <dbReference type="eggNOG" id="KOG2263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_1"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="17">
        <location>
            <begin position="4"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="16">
        <location>
            <begin position="441"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="446"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="446"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV60003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="767" mass="85911" checksum="3A4868A4F0F798CE" modified="2011-11-16" version="1">MVQSSVLGFPRIGGQRELKKITESYWSGKVTVDALLAKGKELRKHNWELQKQAGVDVIASNDFSFYDQVLDLSLLFNVIPDRYLKFDLAPIDILFAMGRGLQRKATDTTAAVDVTALEMVKWFDSNYHYVRPTLSNSTDFKLNESAGLKPVAEYLEAKELGIETRPVIVGPISYLYLGKADKDSLDLEPLSLLEKLVPVYKTLLAKLKEAGAKSVQIDEPILVLDLPESVQAKFQATYEALVDASSPEIILASYFGDVRPNLSAIKSLPVAGFHFDFARVPEQFEEVASILNDKQIFSVGVVDGRNIWKNDFAKSSEIISKAIAKVGADRVLVATSSSLLHTPVDLKSESKLNPTIKDWFSFATQKLDEVVVLTKSAKGDDVTKELEANAASIKSRKESSITTNPKVQSKLAEIDESMATRKSPFEQRLTVQQAKYNLPLFPTTTIGSFPQTKDIRVNRNKFNKGEITAEQYDEFIKKEIAEVVKFQEDIGLDVLVHGEPERNDMVQYFGEKLDGFEFTQNGWVQSYGSRYVRPPIVVGDVSRTVAMSVKESVYAQSLTSKPMKGMLTGPVTCLRWSFPRDDISQKLQALQLSLALREEVVDLEQAGITVIQVDEPALREGLPLRAGKERSDYLDWAAQSFRVSTSGVDDSTQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDPNYIQEFSNYPNHIGLGLFDIHSPRIPSKDEFVKRISEILKVYPANKFWVNPDCGLKTRGWTEVKASLTNMVDAAKHFREQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF97</accession>
    <name>G3BF97_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_126759</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF97"/>
    <dbReference type="STRING" id="590646.G3BF97"/>
    <dbReference type="GeneID" id="18249195"/>
    <dbReference type="KEGG" id="cten:18249195"/>
    <dbReference type="eggNOG" id="KOG1223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_1"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="235"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="512" mass="57629" checksum="404EBEB9F7260108" modified="2011-11-16" version="1">MFSDIQPSTATLKSIVEAQVPDGKRKLYPLYKYVSVDDLTVHVTYLKLASLNNPNRSPSFLLESSAHGDKVDRYSFIGINPKKVIRTGDDETIDPQFRNVDPITVLEAELNKYHQVSLPGLPKLSGGAIGYISYDCIKYFEPKTRRDLKDVLQVPEAVLMLSDTIVVFDHVFQRFQIIHNVEIDSVDQVDAKIEEAKNELDAIEKLIKADLPADQYNPHQPPIKQGQHFTSNIGKEGYEGHVTHLKERILKGDIFQAVPSQRVARPTSLHPFNIYRHLRTVNPSPYLFYIDLIDFQIIGASPELLVKSDENGKIITHPIAGTIHRGKTKEEDEENASILRASLKDRAEHIMLVDLARNDVNRVCTPESNSVDRLLTIERFSHVMHLVSEVSGTLREDKTRFDAFRSIFPAGTVSGAPKVRAMELIGELEKEKRGVYAGAVGQWSYDGKNMDTCIALRTMVYKNGVAYLQAGGGIVFDSDEYDEYIETMNKMNANNNTIVEAEQIWAEKVGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFG7</accession>
    <name>G3BFG7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="6" type="ORF">CANTEDRAFT_96130</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689902.1">
        <property type="nucleotide sequence ID" value="XM_006689839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFG7"/>
    <dbReference type="STRING" id="590646.G3BFG7"/>
    <dbReference type="GeneID" id="18250584"/>
    <dbReference type="KEGG" id="cten:18250584"/>
    <dbReference type="eggNOG" id="ENOG502S3YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121031_0_0_1"/>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="194" mass="22140" checksum="CE1BE16179BF687C" modified="2011-11-16" version="1">MSNGQFIQQRLDSLNDIDSSIVSLLGYMSDIFDRYSTPSNNSDDAKDTIETQTRLIYQTLSDIAINLRKEVKIMDDNTGVFDKNEDQVMILPIPVDQKNTALGKRRLNEEIDLLTHLIPQEPTEDQKFKPEPETVEEESVKEEPVEEEPVEEEPVKEEQPEEKNGVDDTDEPDPIVKPEADVETFGISDVEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFH2</accession>
    <name>G3BFH2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_128165</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFH2"/>
    <dbReference type="STRING" id="590646.G3BFH2"/>
    <dbReference type="GeneID" id="18249285"/>
    <dbReference type="KEGG" id="cten:18249285"/>
    <dbReference type="eggNOG" id="KOG0279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_7_1"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="318" mass="34555" checksum="E1BA6AC9262F764F" modified="2011-11-16" version="1">MASQEVLVLRGTLEGHNGWVTSLATTAAHPDLLLSGSRDKTLITWKLTGGEDSQYGVPKKSFKGHSHIVQDVTISADGAYALSGSWDKTLRLWDLETGECTKRFVGHTGDVLSVSIAQNLRQIVSASRDKTVKVWNTIGECMQTLTGHGDWVSAVRFSPKENDVSTVISASWDKTIKSWDLSEYKLNADFIGHTGYISCITISPDGSLCASAGKDGAIILWDLNVHKSLYTLNAGSEVHALAFSPSRYWVAAATSTGIKIFNLQERSLLDELKPEFAIGAKAKDPEPISLTWSADGQTLFAGYTDSLIRVWQVMTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AVY4</accession>
    <name>G3AVY4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112068</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996507">
        <property type="protein sequence ID" value="EGV66899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AVY4"/>
    <dbReference type="STRING" id="590646.G3AVY4"/>
    <dbReference type="GeneID" id="18246342"/>
    <dbReference type="KEGG" id="cten:18246342"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="340" mass="37760" checksum="4017E50E9AA416C2" modified="2011-11-16" version="1">MEPVPITTKGFGTMSLTGTATPQPLDKSVATLKHVKDTYGVKFLDCGEFYQFNPEFHNLKLAKIFCEQEQDKDIVICVKGAFKVPSMVPDASPENLNKCIDETISYFKDLKVKPKIIYEAARVDKNYTVEDVTSRIYERVKAGDIDGVALSEVSAESIKKAASVAPISAIEVEFSLFSEDILKNGVLAEASKHQIPILAYSPVGRGLLTNYAAEHPDYLSTLSEHDFKRTYDWFQPGNFEKNKGRLTALYNFAKSKNLTLERLALSYLESLSGLENFLGIPKVTKIIPIPSGSTPEKVDRNYKGLVKLSREDVVAVNKILEEHPVYGVRYNAHASALLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWK2</accession>
    <name>G3AWK2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_100903</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWK2"/>
    <dbReference type="STRING" id="590646.G3AWK2"/>
    <dbReference type="GeneID" id="18245418"/>
    <dbReference type="KEGG" id="cten:18245418"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025685_0_0_1"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF178">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00463">
        <property type="entry name" value="AIM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="11">
        <location>
            <begin position="127"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="683" mass="78994" checksum="9580BA6054F23515" modified="2011-11-16" version="1">MEYLANSYFHYPASKSRDYVHLRQDTTNKYGNLTWVVLVTFLIGVTGVNTLVKRGFYIHSHVRILRWLYTKFSNRGGAAEMFRRVIFSFHYHLSTIVQLTFWLIILSSLSLSELYDGDLIFLTKRLGKIATNSLPTILFLTLRPSPLPNTLYLALIPVHKWLSRFIILQSVVHTIIYLGYFNTQNSWNKAWKVENLYGWLALFGFLIILVTSLSKFRNYFYKVFYFFHYLCTWVIVIALQYHVRPVKCTPFTIANLVIMVFQIVNRVLMTRRSQMGDLRITDVSPNLIYIEFPNKLITKPSLTPASHIRLAKYSDNAWRRIYQNLIPNYHPYTLVSLPNDFTQKLIIKKGKFKFTDQKYLITGGYDANLLFIHNNTDKFQISKLKVDTKRVLIVVGGSAISFALPILRVMNYHGVPVKIVWVVRDYRDIAVLKYFDGYVHGDDFEIFVTGSETVEEPNGTRSYGTCNTSLGAPRIIDPRRDETESLLDHTVTSRWEDENVDISMIEESEEEVQDDDCCKDSQKGSTIEGSDIFEDFNDVEVIEDDIMSDLSRTHSTRTTTSSGTNEHFIPRTRSINDINRGHLDRYRETIERLNISNKIYKGRPKLNYRYYNWCLHEGFTQCSGPVSLGGGMVCCRDLPRNNVSDADASKVWVLSAGPIGLVTNVKIWAKENGLKFHEEAFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWT5</accession>
    <name>G3AWT5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_100553</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWT5"/>
    <dbReference type="STRING" id="590646.G3AWT5"/>
    <dbReference type="GeneID" id="18245393"/>
    <dbReference type="KEGG" id="cten:18245393"/>
    <dbReference type="eggNOG" id="KOG1058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006949_0_0_1"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="18"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="667"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="807"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="948" mass="106197" checksum="197204C6C24F83E9" modified="2011-11-16" version="1">MSNPSYTLVYDPNSATTKTSVNEFKNLLEKGKDDAKIEAMKRILITIINGDPMPDLLMHIIRFIMPSKNKELKKLLYFYWEVCPKLAEDGKLRQEMILVCNAIQRDLKHPNEFIRGNTLRFLGKLKEAELLETLVPNVRQCLTHRHAYVRKNAVFALHSIYKVSEHLVPDVADEIYGFLYNETDSVCKRNAFVCLGDLNREAALQYIQDNIQIIDTLDPLLQLAFIEFIRKDSVKNTNLRPQYTTLISELIESSSNIVVYEAATTLTVLSNNSQSILLAGSKFVELANKETDNNVKIITLERINELNKQHPGVLQELSLEVLRVLSSQDLDVRKKALAVTLQFVTSRNVEDVVKLLKKELQATSTSDEDKSSEYRQTLINAIHQLAIKFVEVAANVVDLLLESMKELNTSAAYEVITFVKEVVEKFPDLRPNIIKGLIATLPDSKSGKVLRGALWIIGEYCLEESLIQDAWKYIRNGVGEVPILASEKRAVEPKSTEAEADSDDTKTHKKGPVVLPDGTYATENAFTAESTSPEESEDKPAIRKLILSGDFYLAAVLCSTLVKLILRLQRLDVAQKLLNGLKAEALLTMVSILRVGESKYVAKKIDEDSADRIFSYIKYLNDEKDAEVIQRGFLDDTKDAFKSQVRESELKKAEEVAKDLHANAEQVDEAILFRQFDKNGGIATKNLDDEVNGLSTSDIKKDLVSSKLSKIIQLTGFSDPVYAEAFLTVHQYDVVLDVLLVNQTTTTLRNVSVEFATLGDLKVVDKPATADIAPHGFYKVQCTIKVTSADTGVIFGNIVYDGVHSDESTIVIFNDVHIDILDYIKPATCTESAFRKMWNEFEWENKITIKSEMGSLKEYLEELMRGTNMNCLTPGAAVGEECQFLSANLYSKSSFGEDALANLCIEQSQGQIIGHVRIRSKGQGLALSLGDKVATISRKRKKVEITHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWT9</accession>
    <name>G3AWT9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112329</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683876.1">
        <property type="nucleotide sequence ID" value="XM_006683813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWT9"/>
    <dbReference type="GeneID" id="18246472"/>
    <dbReference type="KEGG" id="cten:18246472"/>
    <dbReference type="eggNOG" id="ENOG502RIXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_1_1_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="706" mass="79628" checksum="43D52D2EAE90CF13" modified="2011-11-16" version="1">MIFTFDSKKQSKTDNHLSSRKRPPPSFDSTGALSAPSAFRVLEDDGFTSFKQTKRSKRGCLTCKIRKKKCDETTPVCSDCSRLGKRCVYIDYDNMHPSEIKSLKEMVEKSESTLKLRKRKKPSQDQGSPGRKWVRTDVEYTPLITAESPMANFSSPNSPNIINLLNNEIEEIMPKPKQKVEPEQKESSDSPDDALCVEEMGGVHYVDKLVKYSATSPSSSQQNSPFITSYDMISFLKETVPDFSFGKSSPLEIPSAPASPLAAFANLDFSQMISTLNHPSPRMTPTVLSDLSSRANYLYDYYVHVICPKISVAPTSAKHGDNQYERVFLPLAQNDIGVMYSILSWACFALGREDDIKEGMEYIRLAINHFFSNKSTERAMVVNKLALLLIVLGAEICRGDVKNWTRYMDWGSNLLHQIGGLGSFNKSKEEIWLISNFAYHDVLSSNKADRGLYFSGEQYDRIFSHDLSNGIMHPLVGIAKDIYICIGMISTLVFETNQKLMTLNNELNEKNVSDSPKTEVGIGTSDINKFEEESDLSNHAKVNEILLSVKASAMELDAKIEAAKPNSEDLINLTDQEFEWQITLFETFKLSAKLYLRQAILRCNPSSLESQILTNDLVKCLDIILGSPVQTVLSFPVFMAGIHCVTVLDRQFMTARIEQYIRTYGPWSLTRVRAVIEKIWEFNPKGDTVVDWHGVLKEFGWEINFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXU0</accession>
    <name>G3AXU0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_118228</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_1_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="133"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="503"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="806"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1120"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1387" mass="156738" checksum="F3C2A531494F3BF1" modified="2011-11-16" version="1">MAHLENLAPLKKERRLFSFLFPKNPPPINSPEERKSYPWKDVNLLSRGIFYWLLPILAKGYQRTLVPDDLYHLTEELTVEHMHLKFDTLLQKHLDDLRQKHLKDHADLSDFKWPVHLVPLCLFKTFQLQYTMSCIFLGLSFCCQALSPLLTRKLIDFVEYRALGFERTLNKGIGYTLGSVVLIYVNGLLLNHFFHNAMVTGAQCKAILTKSVLLKSFKLTSKAKHSFPPGRITSMVTTDLSRIDLAVGFQPLVVCFPIPVIIAIGLLLKFIGVTALTGIGLFFVSLIICVLLTTKLFNTRETVVDYTDERIGLMREILTNLKVIKFYAWEMAYKLRITSVREQEMKYLFTIKVLRNFITAYAVTLPVVSSMLSFVTLWAAEAMKDAGRVFSSLSLFSILAQAIMLLPIALATGADAMIGFRRLREFLSADEYNSDLEDQLNALNTRFIIGDDYLGEKVPDADKGVALEVTNGEFVWETFNEDLENEDLWELEKIISESARHSMDLGDLNQPTSSDLSLNSADAVFNGLTNVNLRIKRNEFIVITGVIGSGKSSLLSALAGFMKLKSGDLKIYDKSVLCSQPWIQNSTVRNNITFGSPFDPVKYNKVLYACALEDDLKLLPARDMTEIGERGITLSGGQKARINLARAVYAEPDTILLDDVLSAVDSRVGKHIVNNLFNGLLKDKTRVLATHQLSFIDNADRVVFLNGDGTIDVGTIDELSARNASFRKLFEFNLVMADKKDVDEVISEDDSNRSAMQYNDIDDFAMNELGRVVEAEEKGANSISWDVYKKYIDLGSGIFGWAAAPIFIFLMCLATFCQVFTNTWLSYWMERKFPGKSDHFYVGFYVAFAFLTVIFTAIEFTMLAYMNSKSAEILNVRAVEKVLHAPMSFMDTNPLGRILNRFTKDTDSLDNEIGEQLRLFLFPLATIIGIIILCISYLPYFAVAVPFLAISFIFISNFYQASSREIKRLEAVQRSLVYNNFNETLTGMSTIKTYKAEDVFIKRNDEFINKMNEAYFLSIATQRWLSVHLDIVAAIFALIICMLCITDQFNISASSTGLLLNYVIQIVGLLSLTVRSMTQVESEMNSVERLYEYAFKLDQEAAYKQTEFQPPAEWPQTGYIQFEDVNLKYRPNLPLVLKDLNFSIYPGEKVGICGRTGAGKSSITTALYRLCELASGRILIDGLDISNMGLFDLRSRLSIIPQDPVLFQGSIRKNLDPFSESTDEKLWDSLRRAGLIDETVLEKIKATKFDPKNKMGFDQLHKFHLDQNVEDEGENFSLGERQLLALARALVRNSKILILDEATSSVDYETDSRIQETIAKEFADCTILCIAHRLKTILNYDRILVIDKGEVVEKGTPLSLFHTDGVFSNMCEKANIDAGDFEHVIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXW5</accession>
    <name>G3AXW5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101870</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684283.1">
        <property type="nucleotide sequence ID" value="XM_006684220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXW5"/>
    <dbReference type="STRING" id="590646.G3AXW5"/>
    <dbReference type="GeneID" id="18245509"/>
    <dbReference type="KEGG" id="cten:18245509"/>
    <dbReference type="eggNOG" id="KOG2360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_7_4_1"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="239"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="496" mass="56588" checksum="3255520339359E27" modified="2011-11-16" version="1">MKLYFEAEKYLRSSGNERGSLQSRIFNEKSLTNSPKHVFALVISTLKYKEYIVKVIKASKLKASPIIKKLRVTDEMLWLLTHDLLFQAKGRIQSGKHPIKDAFLQHKTRLTSELIKLKLKYKIKSVEEFPNLKGQNDETPIRWFRVNQIKITTAVFFEKYDFFKKLQPVSDISEITSTGFLYQDDFVPNLYGVHNRELIMKSDAYAKGELIIQDRASCFPGHILFNDPQFQPTHIIDACAAPGNKTTHTASYLYDKPSSVVYAFERDNKRVEILKKMCNLASNKPNLIQITHADFTSVNPNDFKDIEALVVDPSCSGSGIFGRAIEDSLEQHKEEISTERLNKLSRFQFSIMKHALSFPGAKKVVYSTCSIHAEENERVVVDLLLDENVKKAGWTLAPRNVVISTWPRRGWPQEFTALQEEGRSVGDLAGGCVRAVAKEDGGIGFFAACFVRREAASRGEGEEKEEQEQELELEDELEEEEQEEEQEEEDWTGFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXX4</accession>
    <name>G3AXX4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_92041</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXX4"/>
    <dbReference type="eggNOG" id="ENOG502RQHI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1981373_0_0_1"/>
    <dbReference type="OrthoDB" id="4006634at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="114" mass="12922" checksum="BA7B9C5963A7B800" modified="2011-11-16" version="1">MLILSECSHSSNKEDSELGVLAKWWTENTIPNSLDDLDLSDAFVVKNVQDRGEYYERPKDATGVIVSSQKKLAAMAAWRNKEHKGPWQIYGEQETNTTAFHYVGDSDIVFIGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXZ4</accession>
    <name>G3AXZ4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_118315</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXZ4"/>
    <dbReference type="STRING" id="590646.G3AXZ4"/>
    <dbReference type="eggNOG" id="KOG3414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117348_0_0_1"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="143" mass="16654" checksum="435F85343D127A57" modified="2011-11-16" version="1">MGSVFLPHLHTGWHVDQAILSEDDRLVVVRFGRDYDRDCMIIDELLYGVAEKVKNFAVIYLCDIEEVPDFNEMYELYDPCTVMFFYRNKHMLCDFGTGNNNKMNFLIKDKQELIDILEVIYRGASKGKGLVVSPKDYSSQRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXZ6</accession>
    <name>G3AXZ6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_92057</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXZ6"/>
    <dbReference type="STRING" id="590646.G3AXZ6"/>
    <dbReference type="GeneID" id="18250148"/>
    <dbReference type="KEGG" id="cten:18250148"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_1_1_1"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000017">
        <property type="entry name" value="Ccaat-binding factor complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="93"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="268" mass="30060" checksum="503B746F2037DB46" modified="2011-11-16" version="1">MDRYRSEYLEDEELDLQQQGSSAHPEPELVTSHQNIVDEAELLAAQAAAEAAAAEQQQQPGNAFSNVGQGLVAEHRDLMIQYWQETIDSIENDEHDFKNHQLPLARIKKVMKTDEDVKMISAEAPILFAKGCDIFITELTMRAWIHAEENKRRTLQKSDIAAALSKSDMFDFLIDIVPREEEKPKKPNPKHMAGPLPSTKISNGNPDSGDRNTSPVSVQAPLSGVPQPQPPQPHQLQHQQSQVPERSQPPGNGNYSNFEGYGQFEDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY01</accession>
    <name>G3AY01_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.142</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Asparagine-linked glycosylation protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Beta-1,4-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">GDP-mannose-dolichol diphosphochitobiose mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_101732</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13865"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="EC" id="2.4.1.142"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:13866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="4"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY01"/>
    <dbReference type="STRING" id="590646.G3AY01"/>
    <dbReference type="GeneID" id="18245495"/>
    <dbReference type="KEGG" id="cten:18245495"/>
    <dbReference type="eggNOG" id="KOG2941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012079_0_0_1"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="19">
        <location>
            <begin position="265"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV65737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="462" mass="53073" checksum="D248078A981C08DD" modified="2011-11-16" version="1">MFGLEDLSIDTLTEVNLWGTWVYWLIGIYFCLPILGYVVLPFLTHRNQTGGRRSIAIFVLGDLGHSPRMCYHARSFAGLDYQVNLCGYLESELAPDLLDHPGIDIHSIPIIKNSRNLPFILFASQKIVLQIYYLFDLLFEFRGTKYIMIQNPPSMPLLLVVIVFIKLFSNSELIIDWHNLNYSILNLRYNNQRHPIVRLLKLYEKWLGRFADLNLTVTKSMKQFLVDEFGLNSKSIKVLYDRPGDQFSPLERLEYSKDEIKSHEIFKHVKNLEEYKILISSTSFTPDEDFNVLLNALKLYDDDAESTQKLLMIVTGKGPLKNPFLRTVEDLKFSSKVVVQSVWLLIEDYPLIISVADIAISLHTSSSGLDLPMKILDFFGCGVPVISLNFPSIGELVKHGKNGLITNSQDKQGEPEELYRLLKLILSDPALMRTIGEGAMEESELRWRANWNHTVGEIFRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY07</accession>
    <name>G3AY07_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_118349</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684314.1">
        <property type="nucleotide sequence ID" value="XM_006684251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY07"/>
    <dbReference type="GeneID" id="18248634"/>
    <dbReference type="KEGG" id="cten:18248634"/>
    <dbReference type="eggNOG" id="KOG4653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006300_1_0_1"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057407">
        <property type="entry name" value="HEAT_TANGO6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23565">
        <property type="entry name" value="ARM_TANGO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 HEAT repeat" evidence="5">
        <location>
            <begin position="300"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="737"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="948"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="998" mass="113332" checksum="D8E7197E74208186" modified="2011-11-16" version="1">MPPKIEEVSGKSSTRKHNPFEPKPKKTTIRRDAKEIYGADGKRKGLHKPQYTKGSPLDKSFSLLEDVLQGTLDDITLSVLAERLKIHSEDEFDVRYSVISRLLDFLLQIQEQSGKENQPDKNLINISLHDIKTFSKLVNMIIIHGVYPGLATFKVGIPLAKRRLNEFSKTKKPIKVERIPSNTTAKTYTERFGKEEKLLNLLYSKFKSLFEKEGDVRDLLTKGTGYSDFLTISITLITCPYFNNNKKALVEEFESLVVQLPGTYELFQTYSLLLSTPSPAYFKQFVMKKLQTLHYDAPKKDGVLTLVEFVLGLRENEDVSVERFDHVANVILAKPKHISTVHYFTSIGNQLYDILVNINRPHVTSCIGHVLEMLWVRNKLVVNDFFLKRLWDNLNPTIEDKPDDGVLVSEKDFNNAINVLISLTKKSLSPDFSQYVFNPILLPLWRYFVFVFESKKSYEVLLNILVGYFVTTGQSDDINKDIYGLDTISKNLLFSTEDWEFMWGPNNLPQITKSKFVLQEDRDKKMVNFFSDLDTGSEAYIELLKNLDDALVSKVFKTLLRRWLKLGNNKDVLDSQGHNPFIVLVDLRLIESIGSQFKEDIAKTPIDMLQIVDEFLSAQKNTNSRGRNDLNIVKDSDDEDSDDEENFDSDVNSEAMPILFQLLSAILTDVSEDDITENCKVLLKKVLSSLKVLSKHSNPTIVSSLNTIKALASRISSMLAGDTPVTSEKDLHRRTLERAITSLNDPLVPIRAHGLYLLRELIEVKSDVISLDFVINLHLIQLKDPEPFIYLNVIKGLESLINLGKLPVIQILVGVYTNEAGNNDIDERLRIGEVLLRFIQSSNQLFAGEIAETIVSATVSMIRRSESGPKNQDNRIRMSSMSLLGVCCKVNPLGILYQLSDILDCAIGILTLETGKDQAIMRRSAVVLIHDLILGTSDTEEVPFPEEYREKVLNTLRYILETDEDLLTREQAQSVLDDIEELVQLAYQEARDKMASSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYA7</accession>
    <name>G3AYA7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112673</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYA7"/>
    <dbReference type="STRING" id="590646.G3AYA7"/>
    <dbReference type="GeneID" id="18246631"/>
    <dbReference type="KEGG" id="cten:18246631"/>
    <dbReference type="eggNOG" id="KOG1589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_1_0_1"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="133" mass="14648" checksum="58786CAFF77086F7" modified="2011-11-16" version="1">MAAATGSKFQRFLQSETGPKTVHFWAPVMKWSLVIAGANDMQRPVEKLSGTQQIALFSTGVIWTRWAGFVIKPRNPLLASVNFFLGGVAGYQLYRIISYRNAAGDSPKEIVSYIFNGEPTKREIPSPELAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYC2</accession>
    <name>G3AYC2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112681</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684767.1">
        <property type="nucleotide sequence ID" value="XM_006684704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYC2"/>
    <dbReference type="STRING" id="590646.G3AYC2"/>
    <dbReference type="GeneID" id="18246635"/>
    <dbReference type="KEGG" id="cten:18246635"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="4055088at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="343" mass="38707" checksum="C93C5DCABDF8F4B2" modified="2011-11-16" version="1">MGTRKHDKEAVLVSGASGFLGGHVVKQLLEKEFFVIATVRSEQAGKVLKSELANIDDFTYELVQLSDKLSFDKVFIKHPNISKIIHTAAPFDFRVPNLRKDVIEATVEGTRNLLASTLENAPNVTHIVNTSNLISHFTLDQYSNTALILNEKCWCNYSFEEGIQNPFKASHYSKANAEKVFWEFISSHKDRFTGSSVSPGFMFGPQPFDQYVLKSSLNTSSELINEVLNLGPEDLDHLPNLFGYLTDVRDVARLQISTFTNESTHNKRLVPVSGQFSMHGILNFAKDRFPKISKQLPPRARVEIKLFQIDDSATREVLDFPLTLGEVTIYDSIKQILQVKNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYJ9</accession>
    <name>G3AYJ9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112738</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYJ9"/>
    <dbReference type="HOGENOM" id="CLU_936887_0_0_1"/>
    <dbReference type="OrthoDB" id="4083304at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="297" mass="35084" checksum="956FA83E11DF1175" modified="2011-11-16" version="1">MSFKEEFEKFYAEYERLTKENQDLLEQNEKLRHQAHEQKLEFENILIQTKRSYKAQYRKHVKKYEMKIEDLTERLRRLMRTNSNKENNGNDIVAFHDIRINGKSGSTEVAKTVPTAPLPLLAVPQLKSTPDPKFMEPSSRTTKPVVVMSSPVKSDFDVLPTQYSSEPESQVASATLDADFTPLQELTPLQRKEWLSNYFTSKYYNDPHFRIDLSRNPITQIEWVLNDFETVDEGDDTPPFMFIKDNTSQEDRIKHEQYELRRRSLIDRCFRQCLEGQNRFTAHILNKFTKSGRYEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYM2</accession>
    <name>G3AYM2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[PSI+] induction protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_102462</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYM2"/>
    <dbReference type="STRING" id="590646.G3AYM2"/>
    <dbReference type="eggNOG" id="ENOG502S5JV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1587513_0_0_1"/>
    <dbReference type="OrthoDB" id="4075427at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18828" checksum="9417192038FFA9C9" modified="2011-11-16" version="1">MFIPSIDICPAKLLSRDISGDVTSTAKSFKSWDTCMDNTACKVIAIVGIVLASLVVMWAISTVIRCVCLGFSCLEALFCCCCRSTSRGYQDKQIQPYENPNMYVRTAPPMYQQQQQYPVSQHAYVPQRSMELGSAHNGYEPAGYQVVDSHSRTDPFQDHKTSYRGNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYQ1</accession>
    <name>G3AYQ1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tom7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112779</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYQ1"/>
    <dbReference type="STRING" id="590646.G3AYQ1"/>
    <dbReference type="eggNOG" id="KOG4449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173610_1_1_1"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="57" mass="6352" checksum="8246CD68A048A9D6" modified="2011-11-16" version="1">MAQIALSDESKERISTLLDYSRTISHYGFIPFILYLGWSATPSKPSLFSLLSPFPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYV7</accession>
    <name>G3AYV7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mannose 6-phosphate receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112816</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="18246690"/>
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    <dbReference type="eggNOG" id="KOG4504">
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    </dbReference>
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    <dbReference type="OrthoDB" id="4504960at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:late endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Man-6-P_rcpt"/>
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        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
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    </dbReference>
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        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
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    </dbReference>
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        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="79"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="281" mass="31010" checksum="12C15A50C6BD597E" modified="2011-11-16" version="1">MISKLYQRITLLVLLILAPLCIYVFNTNTGMSGDIHFLDSLTHLPIAIETPEKNVQISSLGDAKTPEEELLLENLLQLDECTIVNPLSRGFIDLRGLSAGGNEGRPIGWGAKGYDSGVNFTIGICSSPMKKLHDKSEIQDGMNSSLIGAYYKDPKSGQYVSIGEFNTVPKFRGRKLTLTYDGGSFCNIRDENGDKIRKSTLITLTCDREMHSKAAVSYIGNSNDCSYMFEMRSHHVCPTAVKGNSTNAFWIFLIIIASAVIGISSGNILYKQMKKPKRINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ34</accession>
    <name>G3AZ34_CANTC</name>
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        <submittedName>
            <fullName evidence="6">Vacuolar metal transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_102141</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ34"/>
    <dbReference type="STRING" id="590646.G3AZ34"/>
    <dbReference type="GeneID" id="18245532"/>
    <dbReference type="KEGG" id="cten:18245532"/>
    <dbReference type="eggNOG" id="KOG1291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_4_0_1"/>
    <dbReference type="OrthoDB" id="5354116at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF29">
        <property type="entry name" value="IRON TRANSPORTER SMF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
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        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="178"/>
        </location>
    </feature>
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        <location>
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            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="519" mass="56603" checksum="F1AFDAE861A9A4D9" modified="2011-11-16" version="1">MNRVKSVAKDVIAGAKKYASFVGPGIMVSVAYMDPGNYSTAVSSGAMYEYKLLFIIFMSNLFAVILQCLCVKLGTITGLDLAEMCRLHLNPNLNLALYFCAELAIIATDLAEVVGTAISLEILFGIPLFYGVLITILDVLIILMVYHKDGSMKQTRLFEILVSILVLATCLCFILELFKCDFPEGALGGIIKGVLPVNGQIFKEQNALFLSCGIVGSTVMPHSLFLGSALVQSRLKDYDIKHGFITGQDSEDPDSTSIASSSDQELHATIHKFRSISDGTSLSRKYRPSYEAIKYSLNYSYTELVLSLFIIAVFVNSAILIVAGSSLFGKPDADNADLLSIYQMLSYYISPAAGLIFALSMLFSGQSAGIVCTMAGQIISEGFINWSVKPWLRRIITRVLAIVPVLFFIGILGREGVSKIMNSSQVVLSFILPVVSAPLIYFTCKKEYLTVFDTSEHLIINENTALLTGEGQNSSAPVTVRKYTFENGKVLTIASVLTWLIISSLNFYLIIAFANGADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ60</accession>
    <name>G3AZ60_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antagonist of</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_102360</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ60"/>
    <dbReference type="STRING" id="590646.G3AZ60"/>
    <dbReference type="GeneID" id="18245545"/>
    <dbReference type="KEGG" id="cten:18245545"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031725_0_0_1"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09293">
        <property type="entry name" value="AMN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF69">
        <property type="entry name" value="FI18408P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="205"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="442" mass="50523" checksum="A4C9B468D140FE92" modified="2011-11-16" version="1">MDDNNTPLSSPNPLTPKNCFLEQAGKFFDDYKPKKLRLVEEWSPRTPSIFDIPEIVHKILDYAAIQNDNSPQELAPLRRKPLSYNHALLIHGNKRLAEESMKIDTSKDYNCTNVLYNCLFVNKLFNSVANEILGKRFYFEDGHKLKTFVQNVPKSVNFKPTDFKLYKMFHLTNECLQPVLYSLQFQNLQTIEVFMCPRFLPTPEMFEYGQNIKKIVICGSKCLDDDYLIMISTKCPNLEVLDIRGCELVTDSGIYHIGKNCHKLTSINLGRKSKGHLITDAGVSTLVKNNVNLDTVGLAGCHITDKTLWDLTTYCNYSIQRISVNSCPLVTNQSIPLILHANYLPLLNVLEIRFTKVDNLKPIIEFKRRQEFNGVSILIEMCEALSFKMRQQELELDKSISERIFNDIQDWANDSDDGDTSYLTLLSSRSSGRSSRVTSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ73</accession>
    <name>G3AZ73_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_119103</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684598.1">
        <property type="nucleotide sequence ID" value="XM_006684535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ73"/>
    <dbReference type="STRING" id="590646.G3AZ73"/>
    <dbReference type="GeneID" id="18248682"/>
    <dbReference type="KEGG" id="cten:18248682"/>
    <dbReference type="eggNOG" id="KOG3798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_2_1_1"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="181"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="442" mass="51228" checksum="75293E5975F6072F" modified="2011-11-16" version="1">MWRSVFQHKGARISAGLLGFYAGSEVYLYFQTQSLIKARQHVSAAMANPDDIDITKFKSATVAGMFVNPFEEYRPQTGFEFMCVRVLELVESFYGNRIELHEHLPNHQTTEDYLKVHKPDLEIFRKNSQIIHQCATTNNYSQLYKKTRRWFSSARLPPLSNQLLFTWLGQSCSLIQISGINILTDPILSDYLIMPHVGPKRLNKSPMTFEDIQFATNNKLDFIMVSHDHPDHLENDLIAKFGNSSTWIVPVGLRKSLARKGVFNVIEMDWWDSVSLNEYMDGNLKDIYEVVCVPSMHWSGRYIVDANFSLWCSYILRKNGKSILYHAGDTGYSKQLFDIIGKKYGPISFSLLPIGQYCPSWHQKPRHISPEECIQICQQTHSKYMMGVHWGTFKLSSEPILEPKNLLTKLSSQLHKLEYYRTPEFGLTYLFDIEHDVEYKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZE3</accession>
    <name>G3AZE3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_92422</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684648.1">
        <property type="nucleotide sequence ID" value="XM_006684585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZE3"/>
    <dbReference type="STRING" id="590646.G3AZE3"/>
    <dbReference type="GeneID" id="18250197"/>
    <dbReference type="KEGG" id="cten:18250197"/>
    <dbReference type="eggNOG" id="KOG1657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084533_0_0_1"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF151">
        <property type="entry name" value="DNA POLYMERASE EPSILON NONCATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="221" mass="23860" checksum="2CA7184C738CBEC7" modified="2011-11-16" version="1">MSSPPPDSQGRMNDTPTTTPPAPTSDIESPAPEPQQMDLDPKSDSDDDSASISLPLSKIKRIFKMDPDYSGASQSAVFATGAATELFVQYITEQASLLAKIDKRKKILYKDFSTAVTSQDSLNFLSDTIPKTVPLRAVLQDQGTVEHEITPQTAPTPTPEQTDRVELPPTRRIDITSMLPVVSGPPPVQQQSTSPPVNKPSINSLISNDSPSNSDDVIMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZE6</accession>
    <name>G3AZE6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112937</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZE6"/>
    <dbReference type="STRING" id="590646.G3AZE6"/>
    <dbReference type="GeneID" id="18246743"/>
    <dbReference type="KEGG" id="cten:18246743"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="362" mass="40243" checksum="C4F5D3A286F489D1" modified="2011-11-16" version="1">MVQANIVVVGAGVSGLTTAVELKKSHPSYDITIVSSHLPGDISPDFTSPFAGANWHSFATIEDKRLQTYDLEGYKRLVQLAETDPKSGIWANDSYCFYSQSAVEEMGNKKPDPWYKHKVENYQTIPPEQLLPGTAHGYRFKGVVITVPIYLNYLLQKALEMGIAIKRVSALKEIGSARQLHSSGKRADVVVNCTGLLAKNIKGYRDPNRQYPVLGQVLHVRNNARTEFAVDGVDPSRPDESLYIFPRKEGGSIIGGCHRENFDSTDEDKELTKRLIDRAIKYAPELIDRSFKNNPEFMDIITVGVGQRPFRDGGVRVEQDPDLHWLVHNYGAGAGGYQGSYGFSSEAVRLVRMAAESIHSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZJ7</accession>
    <name>G3AZJ7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_133003</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684171.1">
        <property type="nucleotide sequence ID" value="XM_006684108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZJ7"/>
    <dbReference type="GeneID" id="18249662"/>
    <dbReference type="KEGG" id="cten:18249662"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="60"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="556" mass="62840" checksum="30FF83B6631AEE6F" modified="2011-11-16" version="1">MSHQEKPEASHHEMVSDNESEKELGVEAENLILNARNATKDEHELTASRALRDYFPAVCWSLIMSSTIIMEGYDTSLMGNFFAFTSFQKKYGVEIAPGSYSLTGQWQSALGCASSIGIIIALAVNGILVERFGHRKIVLVNLVVMAGFLFITVFAKNVEMLLVGQILCGFPWGFFSVVGLIYASEVSPLPLRGFLSAYVMMCWATGQLVACGVLRAMLSNTSHWSYRIPFAVQWAWIPPLFIATWFCPDSPYWLVRRGELEKAEEMVKRLSHKSIHHLAKQRVNLMIYTNELEKDQQDRLDDRYKGWKAYRECFRGTNLRRTEIACMAMAGQVFAGNNFAYLPSYFFSQVGLDSVMTYNMNLAITAVAWVGTFMSWFLANKVGRRKIFLAGLTFMTAFLLVIGILQTPASNTGDLKYSWGQVGCTFGWCVAFVLSLAPLGYTVMSEVSSTRLRAVSIAIGRNAYNLVQLVAQVVEPKFINPTELDMKGRTSYIWFCTSFLLLIWTYFRLPETKDRTYEELDILFEKGISARKFSSYQMDLDAEEIDRVSVKAAAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZU6</accession>
    <name>G3AZU6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_112981</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZU6"/>
    <dbReference type="GeneID" id="18246767"/>
    <dbReference type="KEGG" id="cten:18246767"/>
    <dbReference type="eggNOG" id="KOG2882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_0_0_1"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="312" mass="34661" checksum="409FC5440B54F79A" modified="2011-11-16" version="1">MSKPTKLDTKQHIHQLLDNYDNFLFDCDGVIWLDEVLIPGVLDTINFLQAQGKRVAFISNNSSKSRQEYVEKFDKLGFKNITIDIIYPTCYAAALTVKEELQIPAGSKVWVLGDHGIEEELRQQGYIPVGGSDPALDTEFDLDHQLLQVDPHVKAVVVGSTKKFNYMRIATTLQYLLHQNKSLPFIGTNIDRSYPGHGGLVLPAGGSVVNYMEYTANREFINVGKPSPLLLDTVLKHQGFERDRTVMVGDTLYTDIKFGNDGKLGGGNGGSLLVLSGGTKHHDLEELHTLDQSMVPSFIMDSIGELVHFIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B016</accession>
    <name>G3B016_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_102695</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B016"/>
    <dbReference type="HOGENOM" id="CLU_1839850_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="140" mass="16662" checksum="85AE559CE146C47D" modified="2011-11-16" version="1" fragment="single">GILWVLEQNIIIFTDSFNYIFRGLIWIISGMDSVWNFPFFRTLILDVFTKSLCSYTVCFNSIIQNIVSDSFEYSIFEMLLCGFRSFNYFFLRFFVFIFLAIFIVIVSLFNGFRVFSFRELFDFFRVGEIDVVVEILNGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0R4</accession>
    <name>G3B0R4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113210</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685142.1">
        <property type="nucleotide sequence ID" value="XM_006685079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0R4"/>
    <dbReference type="STRING" id="590646.G3B0R4"/>
    <dbReference type="GeneID" id="18246859"/>
    <dbReference type="KEGG" id="cten:18246859"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_1"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05262">
        <property type="entry name" value="SDR_a7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="297" mass="31701" checksum="7D36EC93F7633A8E" modified="2011-11-16" version="1">MKVFVTGATGFVGTAVVKELVAHGHKVTGLARSDESAEKLIAVGATYVKGELTDTDIVVDAAKTADGTVHLGLVYDAQNPKRREAVDRHIIGAICDAYIGTGKPFIATGGTLFVVNDTKVDEDFQQDFKKIQFAEGRASNELFALSYASKGVRSMSVRLSPSVHDIGDIGFIPTLIEMSKKNGYVYYPGTGENVWPAVHRQDAAVLYRLALEGAPAGSILHGVGEEGIPVKTIAEALSKKLGLTKCSVPAAELPEKLGPRFGVIFALNNPTSNAKTKTITGWKPTEIGLIEDILENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B109</accession>
    <name>G3B109_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113619</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B109"/>
    <dbReference type="STRING" id="590646.G3B109"/>
    <dbReference type="GeneID" id="18247046"/>
    <dbReference type="KEGG" id="cten:18247046"/>
    <dbReference type="eggNOG" id="KOG3041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_0_1_1"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="209" mass="23352" checksum="EDD12DF4F909A260" modified="2011-11-16" version="1">MTKPSPYKAQLVSVEDISQGKWIQTRQINYKDPNGQDRVWEMAVRTTRTETTNTDAVSILALLKHPQKPTEIVFTKQFRPPTGKVVIELPAGLIDPKESVESTAIRELIEETGYHGKVLSSTLDQVELFSDPGLTNANMAFTTMEVDLTQPENINPQPELEPGEFIETFTLPLTNLLDELLDVCKKEGCVIDARLYHYAAGLKMASMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1K3</accession>
    <name>G3B1K3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L21-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112355</name>
        <name evidence="4" type="ORF">CANTEDRAFT_129717</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1K3"/>
    <dbReference type="STRING" id="590646.G3B1K3"/>
    <dbReference type="GeneID" id="18246489"/>
    <dbReference type="GeneID" id="18249404"/>
    <dbReference type="KEGG" id="cten:18246489"/>
    <dbReference type="KEGG" id="cten:18249404"/>
    <dbReference type="eggNOG" id="KOG1732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103610_0_0_1"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18186" checksum="3AF2351E6C9F577A" modified="2011-11-16" version="1">MGKSHGYRSRTRYAFQRDFKKHGVIPLSTYLKTYKVGDIVDIKVNGAVQKGMPHKFYHGKTGIIYNVTKSSVGIIINKVVGHRYIEKRVNIRVEHIKHSACRQEFLNRVKTNAALKREAKANGEQVSLKRQPAKPRDARIVSTEGNVPQTLAPVPYETFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1K5</accession>
    <name>G3B1K5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113236</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685795.1">
        <property type="nucleotide sequence ID" value="XM_006685732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1K5"/>
    <dbReference type="GeneID" id="18246862"/>
    <dbReference type="KEGG" id="cten:18246862"/>
    <dbReference type="HOGENOM" id="CLU_2605802_0_0_1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="79" mass="8707" checksum="D4E9F92C67EA0E4C" modified="2011-11-16" version="1">MSENNQDSPKPTKSAVDMDPSDIYVKIGNKQVPFSSINKPHSVLLGPKHHKPQPPTEDFPDLTPAAKAREAELEEKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1N0</accession>
    <name>G3B1N0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P protein subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_92718</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1N0"/>
    <dbReference type="STRING" id="590646.G3B1N0"/>
    <dbReference type="GeneID" id="18250225"/>
    <dbReference type="KEGG" id="cten:18250225"/>
    <dbReference type="eggNOG" id="KOG4046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080488_0_0_1"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="277" mass="32305" checksum="29481D4451C1D36D" modified="2011-11-16" version="1">MLEKNELERHLLSRCFSDREKIDELLETRYTFTGAQKPSLVLLPTKTEESKAKSLLHSEPTYIDEQLKKRKTNTRLEARTYLKTVKKNQDSLVRKIQEYNRLKLKTPKKPFPLSKLIVKFQIPTYEEFLPMNRLWNDYAQSLAFPEIKSPEDKLPNKQMILARLATAEYSGCLLTVLDSRNPNLLGLKGIVVYDTQYTFIICVERDEDEDATPAKQVGGFRFVPKKFTLFTFDLELPNQTEQDDKYLSFTLIGSRIDTRAVDRSTKKFKSHNVENIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1T5</accession>
    <name>G3B1T5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_113290</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685813.1">
        <property type="nucleotide sequence ID" value="XM_006685750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1T5"/>
    <dbReference type="STRING" id="590646.G3B1T5"/>
    <dbReference type="GeneID" id="18246886"/>
    <dbReference type="KEGG" id="cten:18246886"/>
    <dbReference type="eggNOG" id="KOG3187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034302_6_1_1"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV65008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="214" mass="24357" checksum="CBC921558B26E6C0" modified="2011-11-16" version="1">MAEAHPHKWLITYNSISTSLWTIVLFNSVFLGIALGQPLVFEKTNKINTLIQTVALVEVVNAATGIVRASLFTTGMQVYSRLLVVWGIWQFLPESPANDHWSYISVTIAWALSEIVKYSYHASSLMGNVPYWLAFIRYTAFIVLYPVGVGSEMLIMYLSLDVARAVAGDLMYYFLIINLAFYIPALVHLYTHLLRQRKKVLGKYKKEAVEKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1W8</accession>
    <name>G3B1W8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113317</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1W8"/>
    <dbReference type="STRING" id="590646.G3B1W8"/>
    <dbReference type="GeneID" id="18246897"/>
    <dbReference type="KEGG" id="cten:18246897"/>
    <dbReference type="eggNOG" id="ENOG502RDU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056802_3_0_1"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CREG-like beta-barrel" evidence="1">
        <location>
            <begin position="66"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="251" mass="28200" checksum="518A8D3AEBE3D9D9" modified="2011-11-16" version="1">MNFKNLFVFVQVALTYPIWMLWFDNKDGAESIPHIQNQMSLEEKEVSYNGAEETSNFVSERIPGEIEGASIARTLVSRESLANVNTFKTISQSGKKVDVPVSSVEYYADCDNDGDFFWLVVDIGSSYQNIISGSKYSFSIRVGDHHIHEDVNLEYPGGIVDSPAGSPRIILQGELQDVEDKDGKYGSLEECFLKRHPDSKMWIPNKSQSHKSHWAKFIVDDLYMVGGFGDRAFIGTIDTGIYHSVTSLDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B214</accession>
    <name>G3B214_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VAMP-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_120241</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B214"/>
    <dbReference type="STRING" id="590646.G3B214"/>
    <dbReference type="GeneID" id="18248763"/>
    <dbReference type="KEGG" id="cten:18248763"/>
    <dbReference type="eggNOG" id="KOG0439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072622_0_0_1"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="258" mass="26984" checksum="18F3F6C416E354C0" modified="2011-11-16" version="1">MEVSPATLEFKGDFLSPSTEYLSISNTSSGPLAFKVKTTAPKLYSVRPNASIVGPGESVKVAIILQAFSQPLSKHYKCKDKFLIVSLPCSSDADASKVGEFWPELEKSNKAALVSKKLRVNYVIESTNDDEIKEESSEKADVGVGTGVGAGVASVGTGAGAVTGAASGAAAAAAAGAATAGSSKNIIDPSKVDEEEITKSYKEINKLNQKFDQTEKEKVVPPTSGSTISKISEPFSGVSLPMTVILMILAFIIGWLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B228</accession>
    <name>G3B228_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_97463</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B228"/>
    <dbReference type="STRING" id="590646.G3B228"/>
    <dbReference type="GeneID" id="18250687"/>
    <dbReference type="KEGG" id="cten:18250687"/>
    <dbReference type="eggNOG" id="KOG2916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_1_1"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="301" mass="33999" checksum="F04891B0C7357957" modified="2011-11-16" version="1">MSSSHCRFYENKYPEVDEVVMVNVQEIAEMGAYVKLLEYDNIEGMVLLSELSRRRIRSIQKLIRVGKNEVAVVLRVDKEKGYIDLSKRRVSAEDIVKCDERYNKSKAVHSILRHCAEKFNISLEDLYSTIGWPLSRKFGHVYDAFKISITDPSVWENVTPPSKDILEELQLYISRRLTPQAIKIRADVEVSCFSYEGIDAIKNALREAESISTEQMQVKAKLVAAPLYVISCQALDKAQGIEVLNEAIEKVQVSIEKAGGNCKITMAPKAVTATEDAALQALLESKEEDDKDTSDEEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2A9</accession>
    <name>G3B2A9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_120400</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685439.1">
        <property type="nucleotide sequence ID" value="XM_006685376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2A9"/>
    <dbReference type="GeneID" id="18248775"/>
    <dbReference type="KEGG" id="cten:18248775"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_4_0_1"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="39"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="164" mass="18917" checksum="836819C181842F00" modified="2011-11-16" version="1">MMGIRTSGLCRYLLRPQVPCREYVIPKKTKLPPRPKWLIKEEDIEESFIKGGSGPGGQKINKTNSKVQLKHIPTGIVVTSQHSRSQEQNRQKAREILAEKLDLMENGPKSRVAVVTERKVKLKQSKQKKSHRKYRKIEEGRAKEKEFEELVNIEDEIDQMTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2S1</accession>
    <name>G3B2S1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_103669</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2S1"/>
    <dbReference type="STRING" id="590646.G3B2S1"/>
    <dbReference type="GeneID" id="18245648"/>
    <dbReference type="KEGG" id="cten:18245648"/>
    <dbReference type="eggNOG" id="KOG3055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065050_0_0_1"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="271" mass="30042" checksum="2810C5C1159C8985" modified="2011-11-16" version="1">MTKFRGCIDIHSGQVKQIVGGTLTQDDAVITTDSSTTENFVSTKPSSFYANVYKESQLLGCHVIKLGTNPENDAAAKLACQTWPEKLQVGGGINYNNALTWLDEYKASHVIVTSWLFQGKQLDWNKLKQISELVGKHRLIVDLSCRKVTDNDGHKWVVAMNKWQTLTTSVLSESFLLQVSQYCDEFLIHAADVEGLCNGIDEDLVKKLGEWCPVGFEGKIVYAGGAKSVEDLDRVSELSDNKVDLTYGSALDLFGGKLVKYEDLVGWNESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B340</accession>
    <name>G3B340_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114105</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B340"/>
    <dbReference type="STRING" id="590646.G3B340"/>
    <dbReference type="GeneID" id="18247266"/>
    <dbReference type="KEGG" id="cten:18247266"/>
    <dbReference type="eggNOG" id="KOG1755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120772_1_0_1"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="126" mass="13904" checksum="B3F5573B4B78C102" modified="2011-11-16" version="1">MSWQAYTDNLIATGKIDKAALYSRAGDSLWAQSSGFQLDQKEIFELARGFDDPSQLQATGLHVLGVKYFLLRADERSIYGRQDTQGVICVRTKQTILLAHYPPTTVAGDATAVVEKLADYLISVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B380</accession>
    <name>G3B380_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_122232</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B380"/>
    <dbReference type="STRING" id="590646.G3B380"/>
    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011812_0_0_1"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="596" mass="64528" checksum="0F44819F336D4FA9" modified="2011-11-16" version="1">MSEISPQISDKSKASTGKRKYHQKSRNGCSTCKKRRVKCDEHHPVCNKCSNLKLTCGYMNDPPETYDLPHQAGTKRPRSSDTSLPLEGDSSSVSVSPASVPSRASSVSVHDKAPPSLPSAVPQSVPQTIQTLLNAGNLNNINLSHLVHSLTELGGDLSSLGNLASLTNLATLAQLPIDISNLGTLIDSQLSAGGPSVAASAHPGDHMTPAKATNGAGGPTISPNVSQPFADPTAPMGPESLNMLDLRLMFHYTSQVASTITGAGISDTNIWNYDIPMLAFEHPFLMHSILAFSATHLSRTEKGLDQCVTYHRGDALRLLREAVLDINADNTDALVASALILIMDSLANASFPSSTSPKSLPASAWIFHVKGAATILTAVWPLTEASRFYKFISVDLGDLGDIINQRVHLNKDSLSSEQASKFLTDLECHDSDIADLFPVSIDSPYLVTLAYLNKLHKERYKSDFILRIFAFPALLDKQFLSLLMSGDIKAMRIMRSYYKLLRAFTTEMKDKVWFLEGVSNILPVDVEEYANGAGGMHMMLDFLGGGPSIVDNELDAEMATFEAGNSLKLVDTNNLPSDITSDLEIMQTADTFMNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B396</accession>
    <name>G3B396_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114143</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B396"/>
    <dbReference type="HOGENOM" id="CLU_2043600_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="121" mass="13710" checksum="4B8DDBEE31874EAD" modified="2011-11-16" version="1" fragment="single">MIVKGSLDLETVIFSTTMERSKKRLTKAKKRLTKVKQREWKKSILSISMENWTFQRETATTTSILSTRMMRSVATAKPTPRNGAVMIATNPATKRRNSSSCPCSHSSTIIRNIWISTMTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3G4</accession>
    <name>G3B3G4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114202</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686471.1">
        <property type="nucleotide sequence ID" value="XM_006686408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3G4"/>
    <dbReference type="STRING" id="590646.G3B3G4"/>
    <dbReference type="GeneID" id="18247310"/>
    <dbReference type="KEGG" id="cten:18247310"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032690_2_1_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="225"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="330" mass="37589" checksum="AD31D0B6A9392F00" modified="2011-11-16" version="1">MVSLQQVYENRDQCVMEEKFSLLKVDGTESTYVGKYPLEPYMEGARGTYGGEVIAQSALAAYETVTDSTFQLSSLHSYFLKAGSHESPMRYEVLTTSAGKSFTSKTVNVYQSHNNQHVLVMTCLFAANNSISQRQSDYKSGKSKRFPYQFQSSPGSIFSQYRKGLEEMDDLIPVQHTHDLVEHALPRLYLEKPKKLEMPGEIGDRRLGFFTRILDELPQDAAKVNRIKVADLLYLSDSLYLGLIMRTLGFPISPSSHEFFRVSLDHSVFIHDMDFDPTNYMFVGYRFVRMSNSRVLCFVQFFDLDGKQIATVTQEGLIDLPKYITDGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3H0</accession>
    <name>G3B3H0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCF complex F-box protein MET30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_130487</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3H0"/>
    <dbReference type="STRING" id="590646.G3B3H0"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_1_1"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000016">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit sconB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000715">
        <property type="entry name" value="F-box protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000987">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="298"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="338"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="509"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="580" mass="66122" checksum="FB05477BB16059F4" modified="2011-11-16" version="1">MERSKRERQNESVLTPFLTKHIGDSAQLPEDTYHKYCYRHNPDVHRNKMSEVSKMVKIQQDLEQLAPEDQQAITHVWSIFSAAPNQYRRLILQGILSQCCFPTLSFVSSEVSSLIRIDFIANLPVEISLKILCYLDCASLCNAAQVCKKWKSLADDDRVWHHMCEQHIDRKCPSCGWGLPLMHMKRAREEYDQYHNRKRKIEEVDDDTDKEKKKEESDKENVAVIDKEVKKRPWKSVYSERYKVEKNWRKGLYVCREFVGHKDGITCLQFNVKYLITGSYDATIKIWDIQTGACLRTLAGHTKGIRSLVFDNQKLISCGLDSTIKVWNYHTGQCVSTYRGHEDAVVSVDFSDKTIVSGSADNTVKVWHVDSRTCYTLRGHTDWVNSVKIHSQSHTAFSASDDTTVKMWDLETHKCLKTFGGVESNGHVGQVQCVIPFTYKDKLINDVDLGNISDVDEDNDNDNEISDGGFVEIVTDPNEKNYPTHLLTSSLDNTIKVWDVKTGKCIRTQFGHIEGVWSISADTFRIVSGAHDRMIKVWDLQDGKCLHTWCGDASVSCVGLSDSKFAAGCDNGVVKLFCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3I4</accession>
    <name>G3B3I4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="2">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114218</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="2"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686716.1">
        <property type="nucleotide sequence ID" value="XM_006686653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3I4"/>
    <dbReference type="STRING" id="590646.G3B3I4"/>
    <dbReference type="GeneID" id="18247319"/>
    <dbReference type="KEGG" id="cten:18247319"/>
    <dbReference type="eggNOG" id="ENOG502RXNY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033451_0_0_1"/>
    <dbReference type="OrthoDB" id="4020666at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="214"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="488" mass="53977" checksum="F0EE55E8F5963F6B" modified="2011-11-16" version="1">MNSLKSAYDSLHKEEGVEEKTLEKINSDTNLKYRDVAGAKPTKAILAPNWVYGTTSPRRPTSSVGSGLLLASNGHIAVPSPEVIQNYLYPISPTLQQKILKYRTNLSQLMTSSLDSSTADRPLLVLVGPSAIKNSNQIKACSQWIGTLLGKRFQYTPTQCASEVQQIFNSTYKPANLMLSMRANLSQYTTPYAEFDQIQSFAGSVSTFEVSHGMPYCRALLDDLCEICPIVGDISDTLTPQYLSDLFCYGLVSSTLIESQLHRELVSGVSFPVGFSTSDSNLSFDKLMYKHKLQSGLDAMFASTQPHQFLSVTKLGTATVVGTTGNDETFILVEVNTDLTLEDVQECIDKVYSDKPLRLHYPRIMLDVGKLSADDYDHKLDVVATLLSSSSYYKSTILGVVVDSGDDYVPTSYKSDLTQTGFAAASDDNANHDEGFEEMKRYFTRNSLGSTDTVSYDESMQESSFEYFINANKFISQLDKLKSQNSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3P4</accession>
    <name>G3B3P4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_104700</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686515.1">
        <property type="nucleotide sequence ID" value="XM_006686452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3P4"/>
    <dbReference type="STRING" id="590646.G3B3P4"/>
    <dbReference type="GeneID" id="18245748"/>
    <dbReference type="KEGG" id="cten:18245748"/>
    <dbReference type="eggNOG" id="KOG2671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029646_3_0_1"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000260">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="183"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="438" mass="50591" checksum="971D096BAC7A5DE1" modified="2011-11-16" version="1">MKDYLIYFAQAYPEFRKAELESLASLHGIPLDLSHHDSSSPFLIVQLESDEHARKIIQRAILSKGIYELWGSGNNLDELRKNVRDISFDKFDTYKQGTFKFQFEGYMGKREGPERFEIIESFAFMAFEGKVRMKNPDQIYTLLEEYEVQGMERATTPKRLWLGRQIQLSARTNNILEKYDLRRRKYIGTTSFDAELALVSCNIAEVDTNKMVYDPFTGTGSFLVAAANFGGITIGSDIDVRILRGKGDKCNLKSNFKQYGTSTNFIDTLTMDFTNNALRTDFPIDTIVCDPPYGVREGLKVCGAKNEEKAAGRENVVIDGEKAHLRRDFIPPKKPYELSNLLDDLLRFSANRLPVGGRLAFWMPTANDEFEINQIPQHENLELLYNLEQEFHKWSRRLLVYVKRGNDYMGITRNGLKENHIKNFRERYFMGFSENSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3P6</accession>
    <name>G3B3P6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_122543</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686517.1">
        <property type="nucleotide sequence ID" value="XM_006686454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3P6"/>
    <dbReference type="STRING" id="590646.G3B3P6"/>
    <dbReference type="GeneID" id="18248905"/>
    <dbReference type="KEGG" id="cten:18248905"/>
    <dbReference type="eggNOG" id="ENOG502QQ16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013298_1_0_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="66124" checksum="2EE6FD29B406DB69" modified="2011-11-16" version="1">MLVLRRKKVQAVAVSALAIIAVVTIVWQALNFNEFEVEIKSSLVGENSKISSFFTPKTKPFSETEAGKQAEIDANINNFDALTEEHKYQLVNQLAGAPSTKNFQFLSSVFEKIYKFRPEVAQLTTYKSEERIYHARYNSKDDDSEDNRIVFNEAYLSSFLQLNSIEFGAMQKSHTKVMASLPTADDVPKGMYEGDGIVFVGGGRFNLLTLLSVKAIRDLGSKLPIEILIPTIEEFESNLCFKVLPQYNAKCILLPQVLKQNGLDDNIFKKFEFKGYQYKVLALLLSSFERILFLDSDNTPTRNPDILFSTNPFEDHGLIVWPDFWKRATSPLYYSIAGIKMDQKKYLPRYNELINDYEDIDYSKFPPKEVPFHQFKGAIPDPTSESGQLMINKKTHLSVLVLALYYNLYGPTHYYPLFSQGSDGEGDKETFLAACVALGCKFYQVKKFLKAMGYFNHELSFVGTGMGQFNPINDYTNEEPDLLFIHSNFPKLNPWELKQQGKILDNGKRIRLYGNGVKKDIGFDFELRQWQNMYYFLCKKNVKVNIFNDVVHDDLCKEISQHLSFLKSTSRLTDDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3U2</accession>
    <name>G3B3U2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113770</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3U2"/>
    <dbReference type="STRING" id="590646.G3B3U2"/>
    <dbReference type="eggNOG" id="KOG1677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1180081_0_0_1"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000018">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="235" mass="25073" checksum="F394802152F99D7B" modified="2011-11-16" version="1">MTSIDLLSDLWSTDDTRHLHSHQSPAVRHNIWAGSQYSQNQVSINQATPSQISPPGVSSAVALVASTTSLAALSKVNSNTSTGSSSSCSLLNSGIDYDLNYIYGPSGASTTSAPPFADPCDPFASSGQSLTAANLASINSASPFKSGVSLSPISSTPGSVEDKKPVNTQLYKTELCGSFMKNSYCPYGNKCQFAHGECELKRVERPSNWRSKPCANWSRFGSCRYGNRCCFKHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3U4</accession>
    <name>G3B3U4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Regulatory protein MIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_121320</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in glucose repression of glucose metabolism genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3U4"/>
    <dbReference type="STRING" id="590646.G3B3U4"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033549_0_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="265"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV63735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="333" mass="36314" checksum="67137F2E95DC3F51" modified="2011-11-16" version="1">MGHDDTSGVLAAHGASPNKRDPNSRPYKCPMCDKAFHRLEHQTRHIRTHTGEKPHSCNYPGCFKKFSRSDELTRHSRIHTNPNSRRNKNLSKKKGTGGGAGGTSHDFDTKTTPPASPPNGRADRGSSTTNIDILASAASQELNLLNSKSLPSLTDYFKTSNVSNSFSTNNLQYLSSLAVNQYHPKPKLNTLSSLKRMTPLEMPHASTGILKDTDLDYVKQRLKKSRPNSPTLSTKNFTLPNSPVLGLSSVTTPILSANNSSTNLHSYFQSHNTHGTRHHGVQQPPPAPAPAPVAQTSSYAGSANNEEDTTHLPSIRSLKLDLPKNMSINQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4F2</accession>
    <name>G3B4F2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_121502</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4F2"/>
    <dbReference type="STRING" id="590646.G3B4F2"/>
    <dbReference type="eggNOG" id="KOG3503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184680_1_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.300:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="61" mass="7124" checksum="CF9B48DEF903572E" modified="2011-11-16" version="1">MHLMYTIGPDGKRLYTLKKNTEDGEITKSAHPARFSPDDKYSRQRVTLKKRYGLLPTQQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Q6</accession>
    <name>G3B4Q6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113875</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686160.1">
        <property type="nucleotide sequence ID" value="XM_006686097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Q6"/>
    <dbReference type="GeneID" id="18247157"/>
    <dbReference type="KEGG" id="cten:18247157"/>
    <dbReference type="eggNOG" id="ENOG502T5RX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626810_0_0_1"/>
    <dbReference type="OrthoDB" id="4025680at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="1">
        <location>
            <begin position="53"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="163" mass="18562" checksum="126EF54512FF6DC5" modified="2011-11-16" version="1">MVLTGKVAPEEEEAKVIILDEKARFENQVIKTGQELSQMVERLNGVPVTSSSVTIDKHDSINTRVEEIINKIQVCEVILLTAQSKNINKLITIVEIAKSKGKSIRQYNKLYQLDSVNNPNYKPSHKISTQKQTDLEPKVYLLPILFIYLVPKDIKVELDWTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5J9</accession>
    <name>G3B5J9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_106814</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687041.1">
        <property type="nucleotide sequence ID" value="XM_006686978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5J9"/>
    <dbReference type="STRING" id="590646.G3B5J9"/>
    <dbReference type="GeneID" id="18245917"/>
    <dbReference type="KEGG" id="cten:18245917"/>
    <dbReference type="eggNOG" id="KOG1548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026945_0_2_1"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="300" mass="34990" checksum="83D2AC10A969B001" modified="2011-11-16" version="1">MDEFPPKPPAPGVILKDPLKLKDLDDRISFDNEKKQFIFTQVKGDKTFEYQYSFIVDKWIGITKHVLNQDELEEEANKEEIKQLKKQKISEIKQEKDKLKSMSSRSTGIFISNLPQSITVDELNEEFAKYGTISLDKGNSPRIKLYYDEKDKFKQEALIIYDNATSVDLAIQMMNQVKMKNNILNVEEAKFEPIEDKSQRADEIRSKFYSKVMVIENMFRKQEYKENTKLAEDIEEDIREECEKSGIKDILNVTFFPSDCVVTVKFKSSSSVDTIIESFDKRDYDGLKLNVHTFTGTRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5R9</accession>
    <name>G3B5R9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lanosterol 14-alpha demethylase</fullName>
            <ecNumber evidence="11">1.14.14.154</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome P450 51</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome P450-14DM</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Cytochrome P450-LIA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sterol 14-alpha demethylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">CANTEDRAFT_114587</name>
    </gene>
    <organism evidence="30">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">ATCC 10573</strain>
            <strain evidence="30">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 26">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="11"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5R9"/>
    <dbReference type="STRING" id="590646.G3B5R9"/>
    <dbReference type="eggNOG" id="KOG0684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_15_0_1"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 25 26" id="KW-0349">Heme</keyword>
    <keyword evidence="7 25 26" id="KW-0408">Iron</keyword>
    <keyword evidence="9 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 25 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="28" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 26" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="28" id="KW-0808">Transferase</keyword>
    <keyword evidence="27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="25">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EGV63613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="EGV63614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="530" mass="60353" checksum="C4B3837DDE26FD83" modified="2011-11-16" version="1">MTSMNSTLDYANEAITKNLNIFLGLSLSYKISIVLLIPFVYNLLWQLYCSLRTDRAPLVFHWIPWFGSAVPYGMQPYDFFENCRKKYGDVFAFMLLGKVMTVYLGPKGHEFVFNAKVNDVSAEDAYKHLTTPVFGKGVIYDCPNSKLMEQKKFAKFALTIDSFKTYVPKIREEVLGYFKDHLNMDKNSGQVNVMKIQPEITIFTASRCLCGDEMRKKFDASFAQLYSDLDKGFTPINFVFPHLPLPQYWKRDSAQQKISSAYMSLINKRRSTGDIDPKRDLIDSLMAHSTYKDGVSMTDQEIANLLIGVLMGGQHTSASTSSWFLLHLGENPELQEQLYKELTELLNEKGGDFFDLSYEDLSKLSLHNSVIKETLRMHMPLHSIFRKVKNPVRVPDSKYVVPKGHHVLVSPGYAQTSERFFAFADTFDPHRWETSNASSGKGDEKTVDYGFGAISKGVSSPYLPFGGGRHRCIGEQFAYVQLGVILSTYVYNFKWKLAGKLPDIDWASMVTLPIEEDSNIIWEKREGCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B655</accession>
    <name>G3B655_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_94144</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B655"/>
    <dbReference type="GeneID" id="18250365"/>
    <dbReference type="KEGG" id="cten:18250365"/>
    <dbReference type="HOGENOM" id="CLU_370036_0_0_1"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="752" mass="86501" checksum="F9C0DD8D3B0F2A92" modified="2011-11-16" version="1">MSQKKKRPIQVCNFCRKRKIRCDKKSPCTSCVKFGNKKCDYGLEPNEGSMLTQLTAINSKFINITKTLSAEDSERFLESILQNLEGLEKNLKNGKPDSLSIDFNISNSPFQYKPVSDDQVYYEDSGFGNIDGNKMVVETKSVEPLQEKSRSYSLADYFDDANDGLFKEVFIQSQDRWDDGTGGTEPLSNNLHVPSNNGYKNYSLADYFVDSNQGYFNENYIRFISFTPKAILRNDRIIGHFYTRFYTDSMKVSLFDTSRLPKFTHLDSFVHMHYIEEGITSPDVPRAYSDLYEIHLRAEALLSGFNDINRLLNHFFNYFLPFLPSIDEIQFRVDLMKILKTSGVFVFRVESVDTGNEDNTLILCILLVILKLSSYCEQMESAGDLPMEFIDVAEACLAHFDLSSCSNMLVLQLGVLLLFHQNDAPSYYPPEKSRDLLNALIIMADNMRLSRDPQHKIWHVLHEVNHSLVVNKNFPCNFFACGYVPHTALESTVSEEIYQNLPFLNESFLDIKILLSKIDIFNCEDELLKKFKDTEARLSLWHENHMVNAYNLKCLLVLQTCKLSVMFHLLVIVNVLNKPEYSDMYLGHTIDALRDSIRLISRCNIQSKWFLAHQVIDLVEKIFAITIALFIRVRATEVAINGDKPLFSATCEICFFVCVDFLHQFKFSPKYYKAWKIEIIYKGLFTYIKNQDLTKLGVSQFVGEAYGLRSALKFMQVFMELDNSGFDVFKALEPVGLKEFWTNGKLGNLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B699</accession>
    <name>G3B699_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_114726</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B699"/>
    <dbReference type="STRING" id="590646.G3B699"/>
    <dbReference type="eggNOG" id="KOG2580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020932_2_0_1"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037871">
        <property type="entry name" value="TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="13">
        <location>
            <begin position="242"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="403" mass="45620" checksum="86EDE96E62411772" modified="2011-11-16" version="1">MFSSSSLLWNDARPQSPMKVFFDTFKSEVKKSNELKENIKALQDETGRLGESDAFKKAKEAYDRAQKGGSAAGKVASKAAENIGEVAYKAWESEIGKGVRTTVKSSAQAADKAFEPVRKTQVYKDVSEVIDDGTSNAYGGFLTKEKREKLRQKELQERLKSGKMWKPLSKDEENVRTELVATEHKATGPSFDDKWENFKLKNPIGKVFVLVKERWDESENGLISLIRTIVEKVVGFFAETEQAKVVRQFKQMDPSFRLTDFQKTLTNYIVPELLDAYVKNDEEILKNWLSEAPFNVWKATNKQFVQQGVFSDSKILDLRGVEVVTCKLLQPSDVPVIVVSCRAQEIHLYRNIKTGKVAAGTEDNIQLSTYALVLTRNPEEFHNEVTDGWKVLEFARGGSRPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6D5</accession>
    <name>G3B6D5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114747</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6D5"/>
    <dbReference type="STRING" id="590646.G3B6D5"/>
    <dbReference type="GeneID" id="18247562"/>
    <dbReference type="KEGG" id="cten:18247562"/>
    <dbReference type="eggNOG" id="KOG2380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031403_1_0_1"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="448" mass="50352" checksum="ABA2E4972BA45975" modified="2011-11-16" version="1">MVVVGLEQLKQLQHTKTIGIIGLGDMGAMYARRFSDAGWTVVGCDQEDAYESVKHKFANHKFEVVKNGHYVSRVSDYVIYSVEAKAIGKVIATYAPSSKYGAIIGGQTSCKEPEVEAFEQYCPSDIKIITVHSLHGPNVNPVGQPLVLIKHRANDDDFDFVESLMSCLKSKHVYLTAKQHDQITADTQAVTHAAFLSMGSAWRSTHQYPWETPRWSGGIENAKMNISMRIFSNKWHVYAGLAITNPSAHTQILQYSKSASELFSLMIQGKREDLRARLLKARSLFKHINENELLLDDNLLEKYSLSQVPPGGRQPNSHLSLLAIADTWISLGVVPYDHIICSTPLFRIFLGVTEYLFCTPGLLEESIEVACSDPTFRTDDLEFVIAARQWSDLVTHGNYDLYRTKFEDVQQFFSPMLKEANSVGNEMIKIILARVHESDERAKANHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6S9</accession>
    <name>G3B6S9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_122676</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686804.1">
        <property type="nucleotide sequence ID" value="XM_006686741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6S9"/>
    <dbReference type="STRING" id="590646.G3B6S9"/>
    <dbReference type="GeneID" id="18248919"/>
    <dbReference type="KEGG" id="cten:18248919"/>
    <dbReference type="eggNOG" id="KOG2740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026449_1_0_1"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="217"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="491" mass="54705" checksum="58EF04C439712E00" modified="2011-11-16" version="1">MFEAVYIADTNNNLVYEYLINLSSPSFKSLISVVSSLSADPNNIIEINKNYSVYKYTTSNIIIYTLNVANINPMLPFHFILQLIDVIHDYFGYPLAIPKIESNDDTLTLLISQMIDDGIPNITDFNQLRDIVPFSSFLSKLLGKTSQMTTNAIKKSTSTSISNLPRSQDLNTSSIPWRRSNVRHTNNEMYVDVVETVDVIFKSVAKSLGSAQQVKQFDSAFYSTNSSSTSSYSKSLVPVSSTINGQVLFTSRLTGVPCLQMILNVAGLNNINPKFHRCVKLDTWKQNNGTLSFIPPDGKFTLIKYSIDLDQFSRKDQLSMLGSVSVDYNYGLGLHKNEFEVKLQLPVIKGVTKIENLSIEINANYSNLITIKSSRLTHGDFSYKSNGKAEWNLRSVTPGVNPILYGSIITGDMETDSETFDSERTTQDKTFTKPVLKPAFIKLSYTNKGSLPSGIKVDSLKIVSAKGLSETVKPYKGVKYLTKTGDFIIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B704</accession>
    <name>G3B704_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase D</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rotamase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_106715</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B704"/>
    <dbReference type="STRING" id="590646.G3B704"/>
    <dbReference type="GeneID" id="18245910"/>
    <dbReference type="KEGG" id="cten:18245910"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000022">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="369" mass="40721" checksum="B1ED1CEA1E1ED10B" modified="2011-11-16" version="1">MSRSKVFFDISSAGVPQGRVVFELYDDVVPKTAENFRALCTGEKGKTESGIPLHYKGSTFHRVIKDFMCQGGDFTHGSGIGGESIYGAKFEDENFKLVHNKPFLLSMANAGPNTNGSQFFITTVATPHLDGKHVVFGEVIEGKSVVRKLEKCEKGQNDKPVDDWIIADSGELPADYEPTPVDDGTGDIYEEALQDNRSIDVTKPETVFKAVQAIKDIGTTQLKAGNLDVSFAKYTKAAGLLEEYFPEDLSEQELETVHELKQSLYLNAALVALKLKSGRKTVDYATRAIDEITEEKKEVDKKKSLAKALYRKGMGELLLKDEEAAKISLEQALKYAPEDGAIIKGLSDVRATTKARRDKEKKAMSKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B726</accession>
    <name>G3B726_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein required for protein sorting at the late Golgi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_106623</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B726"/>
    <dbReference type="STRING" id="590646.G3B726"/>
    <dbReference type="GeneID" id="18245904"/>
    <dbReference type="KEGG" id="cten:18245904"/>
    <dbReference type="eggNOG" id="KOG2180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007339_1_0_1"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="8">
        <location>
            <begin position="589"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="800" mass="93633" checksum="56DBBA01E1087F78" modified="2011-11-16" version="1">MNSFEYNPYDDLRQIFQDPQSIKELPQLLKYINDHKLAVSQQINSDINKFHQSNNDLSGKDILELIQSIETTQTKSQRIQTSIQSITCEISKLDLMKKNLTLSMNIFKRLQILSYSINELNQHLKADYRYKDIFDHLNNTKDLLEFFKPYKSIDEINRLHLVMAKIETKLIDNIFIDFEEILVYHKPSKDLKYACMILELIDDKQKDKLLNWFYNLQLKEIKAIFNNFDEAGSLDNLNRRFIYYNNTLKKMRSENADIFPSSWNIELELSKLFCEITKEDLLAKLNQRKVSSETLLSCLNTTLEFENSLNTALKSTDFTRIISKVFEPYLSIWIGDQDRYLNSKMIEFFSVPKIPPEFQSSTSFSEFENVLKINSIPNISNSSIELFKVYQKILIQALKWSNGKIHLDLANLFNKYLAEYHDRILLPIVNSEQNEANEVNQLESIKYLTMVLNTGDYIINNLDDLYKKFNNIISAQYKGKFNFDNLNHLYLNLINRSMNRLIDLISTDLRFSWRQFENNNWNNNEPSEEVSNYMIDIKGCLTKNCKAILPLIIRESYIRTFCNKVTELVVRDFSNNLKLIKPLSILNIEQITNDINNLKQLIMKLPLYSNPNWDDKTLNDKEKDKSLQFYEKYVDNQFYKLEMLLKLLLTPTLPIDNLVGSYFSLIHDNSIKNFKKFLSLKNLSVLEQRKYIDNFNLQLSLANDDLAEESPIMAILKDDSPGPINTNPSVSNTNSGIISPFPNMSSQAEGSKSPKLKINNLEKNLRELALNSESNINKFNENFKNFGKLFRKDNQNQGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7R9</accession>
    <name>G3B7R9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF913-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115771</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7R9"/>
    <dbReference type="STRING" id="590646.G3B7R9"/>
    <dbReference type="eggNOG" id="KOG2744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681513_0_0_1"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45492" checksum="E776747C76C93014" modified="2011-11-16" version="1">MNSSSPEDVDDPIDQFALLDYSTILDEFKAENKHHFSTLQTKSATNEQVLLIDELITVTMILRNISFNGFNKFKITGNDLLRDLMFRIVKMIGSHSEKFLYHRKRLCLLKDCLFLLYNMSQELQLRSLEEAFLSFALVASFGPKLTDDPVVIPPANIDRFTYLPYGIDALTKLLVREPHNRSFMKAVLTGDLSNSNFSTIVDDPAADRANTRALITKYLGTSVINDGSLLTRSFQLFLSVIPFDKNSMELSKFASIRTSVVVQSLFGAKLIIDLVNGEDEVARLRILPVTWLLKNSRSILLNLNRSSVSMISESVKNEYIALVVLKALIMINSLLGNCVLLAEQNVLPKPIEEELHKLVHGHRINPDSDITLETLLNPTVDRNVANELVRQFGLLTQLGQLVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7U1</accession>
    <name>G3B7U1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_109089</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7U1"/>
    <dbReference type="STRING" id="590646.G3B7U1"/>
    <dbReference type="eggNOG" id="ENOG502S7Y8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181953_1_0_1"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="60" mass="6899" checksum="506E36437948955D" modified="2011-11-16" version="1">MAGHGHAYVKHGAVAVPHTDPRLKWGAKLLSATMWFYIFYRVKQDGPVMFGQKLPFEHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8G9</accession>
    <name>G3B8G9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_126271</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8G9"/>
    <dbReference type="STRING" id="590646.G3B8G9"/>
    <dbReference type="GeneID" id="18249157"/>
    <dbReference type="KEGG" id="cten:18249157"/>
    <dbReference type="eggNOG" id="KOG2386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013931_1_0_1"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="510"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="578"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="655" mass="74011" checksum="24DE4BFCFB8BC5B4" modified="2011-11-16" version="1">MNNEDSEHVEISNFSSPKASSSTNVQVSFRKLQDLSTAQFTQTNTVFKKLWQYLRIVLLKKANPFEEYVLEAEPNDSALVAKYSGVTRVDLSRQQGLSVDEVYLKTLHIDHPLTNFMKNENNQSVDISQELKESPILVFVHGMGGQMSQFEPLMALLSQCSEIVSLDLPGFGDSRADFSTASARLTKISPEDQERISTSVASMADGDFTSNNISVIITEFINQTIPPNKKVVLIAHSMGCHLSVRVAKKLPSSKVEGLILLTSPGFQDDIYTNEQVKNSHKTSIFANWMTKFPSVVNLMRVWDRLEGLESSSVFRQIGDTSLYPPHTSLYIKLRQFRWNLDVDTKVILKYIKGFERCKYSDLVAAIKRFNNNPFDTRVYEKTVLVAGTDDKVTPPQKITEIDNMLSHVFQRKVSTLIEIKNAGHGLLLSKPEFISGKILDHIENKFPERLHLSPAWVLRVKADISGDKWGLKNELKWSRLDPISLNISRNHGKDISPLLGMKTLREGDANHSPIILENAFYGDRSMIPSQYKLPTGHLIAIVDISADIPPYDPETFKIITYYKCATVSKVVPDPGSIRKFIQLIDKILESKTIEDPLIAVHCHYGFNRTGFLICCFLIERLGWSVEEAIGGFRDAKPPGIKHRHFIDALYVRYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Z4</accession>
    <name>G3B8Z4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carboxypeptidase</fullName>
            <ecNumber evidence="12">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_98952</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in degradation of small peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="12"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Z4"/>
    <dbReference type="STRING" id="590646.G3B8Z4"/>
    <dbReference type="MEROPS" id="S10.A49"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="520" mass="58769" checksum="E484A6154F73B18A" modified="2011-11-16" version="1">MATSAVNAGFLSGLNQHIFSNNHKKLTVELTNPEYAKVPELAEAWAFISETLSPKQIQRKVDQYTKPVSKFNNKFRGLKGVREGFQTLSHDKFEGYSIDIKQNHPEALGLDTVNQYTGYLNVEKLGKHFFFWFFESRNDPANDPIILWINGGPGCSSTTGLFFELGPSSINSTIQPVYNPYSWNANASVIFLDQPVGVGYSYTEGDQVKNTATAAKDFYVFVELFFQKFPEFRGNKFHIAGESYGGHYIPSFAAEIINNADRTFELSSVLIGNGITDPLIQYKAYRPMGCGEGGYKSVLDEETCEQMDSDYPKCAVLTELCYKFQNPLTCVPATVFCEKKLFGPYDETGLNPYDIRRPCDEPGGECYSGMNYIDEFLNSEYVKATVGAEVDIFTSCDDTVFQNFILDGDEMKPFQQYVAELLEKDVPVLLYAGDKDYICNWLGNHDWSDALEYSGHQAFESAPLRTWVTNNNKFAGQVKNYKKFTFLRVYDAGHMVPYDQPENSLDMVNTWISGDYSFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B918</accession>
    <name>G3B918_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_115904</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B918"/>
    <dbReference type="STRING" id="590646.G3B918"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_912139_0_0_1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="15">
        <location>
            <begin position="6"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV62438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="305" mass="34641" checksum="24A4E0E32BB4C25E" modified="2011-11-16" version="1">MLGHVPLRLEVQYRMNPALSEFPSNMFYEGSLQDGVTVEDRLIKNSTFPWPVQDIPSMFWANYGKEEISGSGSSFLNRVEAMRVEKVVNRLFEDGVKGDQIGIITPYEGQQSFVTRYLATNATQTQYKDEYLSIEVASVDAFQGREKDFIILSCVRANEAQVIGFLRDPRRLNVALTRAKYGMIVLGNPRTLSRNPLWNHLLVHYRERGCLVEGLLENLQMCTVKLDFKAGANTHTSYKQDSPTPSNFSANEFNSEATSMISSNFYSRLSQLDQDYLKQKQHQSHDMNDDDIKSITSSFAAGFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9J9</accession>
    <name>G3B9J9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mo25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_99028</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9J9"/>
    <dbReference type="STRING" id="590646.G3B9J9"/>
    <dbReference type="GeneID" id="18250816"/>
    <dbReference type="KEGG" id="cten:18250816"/>
    <dbReference type="eggNOG" id="KOG1566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035755_0_0_1"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="39570" checksum="6B675CD027A40CD9" modified="2011-11-16" version="1">MSFLFKRNPRTPQEVVRSLNEQISKIDLTNDNHKKYQDDCARFLKQMKVILNGDDETEPQPDQITLLAQEIYQTDCLYYLITNLSKLNFDSRKDVSILFSNLLRRKIGNQSPTVDYLINSKPEIIMLLIKGQVHHEIGLICGSIIRDCIKFEVINSLIIASKVFWNYFGYVQSDIFEVATDSFTTLHDLLTLHKKLVSEFLTSNYDQFNKNINQLIQSKNYVVKRQSVRLLSELVLTRTNQNFLNRYFDDTINLKVVMLLLSDKSKNLQIEGFHIFKFFIAKPKKSQKIMDILIKNKSNFIEFLEKFDLSSLNDSTIIDEKDYVWNEIKKLPEIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9K0</accession>
    <name>G3B9K0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="16">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_115356</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:31763"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:31765"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="16"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9K0"/>
    <dbReference type="STRING" id="590646.G3B9K0"/>
    <dbReference type="GeneID" id="18247834"/>
    <dbReference type="KEGG" id="cten:18247834"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_1_1"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010326">
        <property type="term" value="F:methionine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 16" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10 16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV61909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="371" mass="41023" checksum="91C966CFCFFFD177" modified="2011-11-16" version="1">MSSLDASSLVINKTTTPKAKLPNDQLVFGKTFTDHILEIEWTAENGWATPTINPYHKLELDPSAVVFHYAFELFEGLKAYKDASGNSRLFRVNKNMKRMNASAERIDLPAFDEAELSKLIAKFVEVEQDFIPEGHGYSLYLRPTMIGTTASLGVNTPDKALIFVIASPVGPYYKTGFKPVSLEATENAVRAWPGGSGNSKLGANYAPCIKPQREAATRGHQQNLWLFGEEGFVTEVGTMNAFFVFETEDGKKEIATAPLDGTILEGVTRDSILDLCREKLDPNEWIVSERKFTIHEVKEASAKGKLIEAFGAGTAAIVSPIKNITFRGEDINVPVALGSSGELTKQLLDWIEQIQYGEAEYKNWSTPTKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9L1</accession>
    <name>G3B9L1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF1640-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115372</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9L1"/>
    <dbReference type="STRING" id="590646.G3B9L1"/>
    <dbReference type="eggNOG" id="ENOG502S831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056763_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28620" checksum="A944D9E4E849FB26" modified="2011-11-16" version="1">MSAETQTENIDTVAEDDEYLTTIFEKMEPYMDTYEVFKQLTDAGFTDKQSEEIISLLIVQLNSKLAKLPTKYSQLYELENEKYLFESAQQELRVDVTRSREAQINASISLINGLERDFNIIQDELNNDVLQLKNNNQVTINDEKQENTLASKKMFLKIQEANHKITTELIGTMRSEIESLRWNLSRWGIISILVCVFSGCASFYIYKRKVNAESHNSDEFIPLVIYEPSEFDEDDYHTDLDENVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9R3</accession>
    <name>G3B9R3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DEAD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_108853</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9R3"/>
    <dbReference type="STRING" id="590646.G3B9R3"/>
    <dbReference type="GeneID" id="18246068"/>
    <dbReference type="KEGG" id="cten:18246068"/>
    <dbReference type="eggNOG" id="KOG0340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="33"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="243"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="405"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="448" mass="50531" checksum="1101227A0D686681" modified="2011-11-16" version="1">MSTFHELGVADWLCESLNSMKIHKPTSIQAACIPEVLKGKDCIGGAKTGSGKTIAFGLPMLHKWSEDPFGVYGLVLTPTRELALQIAEQFSAVGSSMNIRVKVIVGGEDMIEQALAIQKKPHFIIATPGRLADHILNSGEDTINGLRRIKFLVLDEADRLLSNSFGKDLDRIFNVLPDSKKRQTLLFTATVTDAVRSLKDKNDKVFVHEIESVDKFIIPSTLSLYYIFVPSYVKEAYLNEVLNLDIYKDKVGIIFVNRTKTAEMLRRMLRKLEFRVTSLHSEMPQTERVNSIQRFKANAAKILIATDVASRGLDIPNVEFVINFDIPADPDDFVHRVGRTARAGKKGDSITVVGEKDIERVLAIEERINDKLKLLEDISDNKLIKDSLKSTSDAKRESLIEMENENFGERRQINKRKHIERENENSKVMKKRNKPKTLKSVKHKSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9R9</accession>
    <name>G3B9R9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="13" type="ORF">CANTEDRAFT_108168</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules and the mitotic spindle poles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9R9"/>
    <dbReference type="STRING" id="590646.G3B9R9"/>
    <dbReference type="GeneID" id="18246008"/>
    <dbReference type="KEGG" id="cten:18246008"/>
    <dbReference type="eggNOG" id="KOG0295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_15_1"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="508" mass="57489" checksum="9FB52CC3FB420097" modified="2011-11-16" version="1">MSNLSILTSKQKEELHKAIIQYIQPLLAEDGDPRLLQSLMKVLQVDDNSINDIIPNYLEKKWSTVLRLQKRIMDMQNDINNMKSITESQPEFFTKNTDKINWLPSTVSQVFKSHSNQQVDTVALHPCLPLIVCGCSDGTIIVWNLVVDDTIPEKIIKAHTRNVNKVVWSKKPIDINDNSTPEYVFASCSSDLSIKVWSGSSYKQLRNLMGHEHTVSSLAFSSSNPRFLYSVSRDRYIKSWDVINGHFTKSFMGHSDWVRNLDTICLNSKPDGSNSDASVTSGFGDFLLTCSNDQSIRLSHAESGMGLSLLIGHGHVVEDVKFLPLHSNRFIDQFLDENGSRFHTMPSRLVKDDIYTTMLGFKYCVSCGRDNSVKLWLLPPPTIHPHRSPTATTMNNSQGWLLDSFSGHTSWVKAVSVHPNGRFIFSCSDDKTIKVWDLEPLKEEGKVKCIHTLKGHEGFVTAIDFASFETDDILNSINDPEKLLKYIESKMRCVFVSASVDNTVRLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAK3</accession>
    <name>G3BAK3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_114901</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAK3"/>
    <dbReference type="STRING" id="590646.G3BAK3"/>
    <dbReference type="GeneID" id="18247627"/>
    <dbReference type="KEGG" id="cten:18247627"/>
    <dbReference type="eggNOG" id="ENOG502S4CX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052195_0_0_1"/>
    <dbReference type="OrthoDB" id="4940293at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF8">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="128"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="305" mass="34711" checksum="898FE2610AB1B33E" modified="2011-11-16" version="1">MEYTNYMSKNEFENGDIGLYNDNQFGLTQQNVYMLDEPVQFPGQYIPNADTFSDRSSPSTNNSNLMTVDHAILSNHHGQKSDLEASSTDENSHKVVTLRNGKGKSKKQLAEEQDTLLLSRDDSELTEEELQLKKKAQNRAAQRAFRERKETRLKELEQKLNKSEEDKQALLNKLEAIRKQNLAMKSENSDLKTSRNNGTTPELKLDFPKNEGDFIARLLEGQEHVYSSSDSKKVYDSPENGQKVLAFGAVWDYLLYRADEDNLNIDVMEVMNSLKGNEKCHGYGPAYPVELIDKAILENSSPNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAX7</accession>
    <name>G3BAX7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_94368</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAX7"/>
    <dbReference type="STRING" id="590646.G3BAX7"/>
    <dbReference type="GeneID" id="18250388"/>
    <dbReference type="KEGG" id="cten:18250388"/>
    <dbReference type="eggNOG" id="ENOG502QURR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017550_0_0_1"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="819" mass="89234" checksum="4431F0573A57F25F" modified="2011-11-16" version="1">MLLLYLLLITLVWASVDVGFPFDEQLPNVARINEAYDFTIANITYEASDGSSVSYEANGLPSWLSFDSGSRTFTGTPSESDVGTFDIELVGTSGTDSLSQTYSMIVSNSSGIELSSANVMFVQISEYGQTNGVDGLVVQEGDKINIQFDKDVFKVKETSDRPIIGYYGRSSDRSSLPNWISFNSDNLSFSGTVPHVTSSNAPSFEYGFSFIGSDYYGYAGAEGIFKIVVGGHQLSTNINETIKVNGTYGAEFDLTVPVFTNVFLDANIIAQENISSVTPQNLPDYITFNQGNYTLTGNYPEDSTFDNFTIVITDVYSNEVELPYSFDSIGSVFTVKNLPSVNATRGKWFSYELLDSYFTDVNATDVSPSYNADWLQYHSRNKTFNGMTPHHLDTLSVKIDASSDFDTESKSFSVKGVDAVRKHSSSSSSSSSSSSSTSSSSSSTSTASASSGAVKSKGHKDNSDLRKKLAIGLGVGVPSLLILVAAIILLCCCVKRRRKTDEEEKSGDTTLEEDEINGPGFGQIDKSPKVLATTNVKKLEKDDIESTSSSITHVDIDSGGSQYYDANDEDEDRPTKSWRANDQSDVAKGVGAGLTKSGNVRQSDASLSTVNTDKLFSVRLVDDQSILRASQQSSFGSGQFISNNSLNALLNREDSGNFQRLDSDGNIVDKTDASPRRHISRSPSSNLGVLVENSLENSREYPSDYLSTSSNFGMRTEHSKNSLHNDYNATQTPEGDYNWIDSNHESYKFLNNGKSLDMELSQNSLASNLSDNPRISSTSIGKKAKLVDFTRRSSLRESAQSLTHTYEGEIAQIHSNDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB85</accession>
    <name>G3BB85_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_124276</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB85"/>
    <dbReference type="STRING" id="590646.G3BB85"/>
    <dbReference type="eggNOG" id="KOG0828">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010475_1_0_1"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000626">
        <property type="entry name" value="Transmembrane ubiquitin ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442794" description="RING-type E3 ubiquitin transferase" evidence="17">
        <location>
            <begin position="25"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="723"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV61515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="785" mass="88912" checksum="FF0A3AB132906198" modified="2011-11-16" version="1">MAVDRQSLIFFIVVFIFLSLPSRNDQPHSHQERETLDTFQKSLKQFRRELNTRDYISGYGNITGFLLSYDDYVSDKSPAEWPLHKYTPEHPWFEDEKYSVLPNAVSDQLKKFWGIDPVPDEDSLGYLLNVSGVATGEFVKPTDQVKEVPLQLPGYLETYFKSITEGAPWDGNSNEGNGGNIPTPDENPKKVGEVKSSSGNVVFKLNSLGYNFQNKQLKKNIEGEQDKIDDAVVVKLQAVVSDHEEIDTNDIELIGVYFQKTGSLVATTNSAKFHGDFALPHLTLSEDKFTKSQKLMGQMVNTTDIDKDISMESMNVFISKSLEQCEFVTFIQLEKTQFSIKELREIDEELANPRGVPIPKTLPKLRVKQSLMYSPDCGMVLNSNPKTAFEGYTHDVITRQSRKLLIGFSVLVACQLYLFMTQIKSLNTPGPLSNISVMTLMFFQYEDSLVTFTFLLISTLFEDLYLILTGITIVTQIMYTVFETGLLVRVCKVQANERGTTWWQILRGSMRKTSRVATPDELPLPVTEPTTTTAAADLAAPESSWNPMFAPGFAVAIVSVLVILNATMWRKSYRRAFEVAGLTVLNSFWIPQFLRNTLKNRRIPFSWTFVVGTSVIRLIPIIYVNVFSNPFRHAQNISFVVFLTCWMGLQLALIALQSILGPRFWINDKWLPQAYNYHPLISLKDLEHGFGSDLLANIGIDDLSQEPEASKKDDSVVHCKTDCAICMAEIDLPIYKHEPTKSAKFTGEKAYMVTPCFHVFHTECLEDWMKYKLQCPVCRNGLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBA3</accession>
    <name>G3BBA3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSF1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114998</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687699.1">
        <property type="nucleotide sequence ID" value="XM_006687636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBA3"/>
    <dbReference type="STRING" id="590646.G3BBA3"/>
    <dbReference type="GeneID" id="18247664"/>
    <dbReference type="KEGG" id="cten:18247664"/>
    <dbReference type="eggNOG" id="KOG3337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067902_3_1_1"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="175" mass="20812" checksum="36159C0AFA00AF32" modified="2011-11-16" version="1">MVQIYKNEHIYPHDFKTVSLAYLNRYPNPYAKHVLSIDTLDTHVDNNGNLVITKLMVKTGPLPMFIKPFLGSNLNSWILEKTIINPQTKRLMTYSANIDHRKFIKVEEFLYYSEIDEYSTQLKSKVKFSSNLIGFKQRIEDWSKHRFASNIEKSRHGLTFVMNELKKQKVYWYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBB2</accession>
    <name>G3BBB2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CIA30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115006</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBB2"/>
    <dbReference type="STRING" id="590646.G3BBB2"/>
    <dbReference type="eggNOG" id="KOG2435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059028_1_1_1"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="34"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="258" mass="29448" checksum="37D32851E34D5106" modified="2011-11-16" version="1">MSLRSLGLNSTFSRIFNMTKPATGVKTADTILDFKHNPQLSLENIMTRSDQEIGGYSTAHFAYNNQMKCGHFSGYLNLDLPKDSPDITRSGYAMFRTKDQKESWLSGNSYWDWSQYHALVLRVNGDKRKYLVNIQANTPLVTDLFQHRLFLNTPGSWETVVIPLDDFVMTNWGVIQDGCEINKSEVKTIGIGLLDKQYGPFNLNIDWVKVMTDEELVNYSRDSLANKKRIDTNENDIKELNSSALHSNKFEDPKGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBG1</accession>
    <name>G3BBG1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_109071</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="13"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBG1"/>
    <dbReference type="STRING" id="590646.G3BBG1"/>
    <dbReference type="GeneID" id="18246083"/>
    <dbReference type="KEGG" id="cten:18246083"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000157">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV62181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="489" mass="56608" checksum="8D3CED8E6E4DD2AF" modified="2011-11-16" version="1">MSDLSHAGRTVNKVFNQEFIIDQRFKIVKELGHGAYGIVCSAKYDDGSANDTEGSFVAIKKITNIFSKKILCKRSLRELKLLQFFRGHKNITCLYDLDIIPNPLTGEFNEVYLYEELMECDMHQIIRSGQPLTDQHYQSFIYQVLCGLKYIHSADVLHRDLKPGNLLVNADCELKICDFGLARGFSEDPEQNAGFMTEYVATRWYRAPEIMLSFTNYTKAIDIWSVGCILAELLGGKPIFRGKDYVDQLNQILLILGTPKESTLTKIGSVRAQNYVRSLPYTRKVEYSELFPTANPLALDLLEHMLTLDPYERITVDEALKHPYFQVWHDPQDEPECQIKFDFKSFETIDDLPTMKQIIIDEVRSFREFVRKPIQEQQQIQLQMQLQKRYEEQLKQHQQQQMEGMDLATPTMPNPSHSHNVSAEVDTNSLDAQNLQYYESIPKPQELDEFTFSRDEQLDNLGELDNNEDLFRLEEELGFGMDGNIFNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBH1</accession>
    <name>G3BBH1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_115656</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBH1"/>
    <dbReference type="STRING" id="590646.G3BBH1"/>
    <dbReference type="GeneID" id="18247954"/>
    <dbReference type="KEGG" id="cten:18247954"/>
    <dbReference type="eggNOG" id="KOG2334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_3_2_1"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="31"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="417" mass="47022" checksum="EDC1E3A993DFFEB1" modified="2011-11-16" version="1">MNYTGKFVLAPMVRSGELPTRLLALRHGADLVWSPEIVDKKLLTCTRSYNSKLNTTEFREPNGRIALSTYKPSEAGKLIFQMGSSSPELAVKAGLMVINDVDGIDLNCGCPKNFSVHSGMGAALLSTPTLLCDILKSLVQKVGDPNNKPISCKIRLLGDLPSTLELVEQICQTGIKNLTLHCRTRSMRNREEPLHDYVPEIIKITKKYNISFIINGNLRNRLDFFELQQRYGPEVGGMVAEGAEANPSVFSINPVPWNEIILEFLQICFKFENHPSNTKYILLNQIPSKSKYYQKFARMKTNLDMLNLAKELQVDKDEPLNGKIKFRHLQKERLQTIEQYSAWKKEVISKLSQDIENVSLGPIDFTKEFSDVGVESSEETVESKSHVTDTNTSTTKITTKRRLSLDNTLPHKTLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBH7</accession>
    <name>G3BBH7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_108216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBH7"/>
    <dbReference type="STRING" id="590646.G3BBH7"/>
    <dbReference type="eggNOG" id="ENOG502R0G6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_480671_0_0_1"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="358"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="562" mass="65397" checksum="24B17874E5C4676E" modified="2011-11-16" version="1">MSTETYKAILKIAVVLISGSIFQSKDDSIDKYLPLYETLIEYLDVIDIMTQKLYLHDSKITYNTIKLVNDLILKALKFQYSGIITLAGRLKHVTLFSTIGNLIDTDDKSILDAISNLKISYAKLNDYLNDTKFDLSIKSHQIMLNNLFLYLEISLNEFGTPAKPEEYIKAGFTENPRKFIVDNATILLAMDLKIFLKDPNMTFKKKFHEELMMSDHNRTFPMYLFIEKATYLWIDVFSHKEKYPRIYDNILSWELMMYYTMNSCLTLWQETKAQLTNDEDVSRIMGLIKDNVYLIEENLTNHLSTKTIEECLDLTLNETNVELRRHQIDRIKGSFSDVWDARFTEFNKQLAFEVMEFVCEQRVIQLLKGSWAANGSVMAAKYYFILLSPNRQYLYYKEFTEKSLQKPSFEEMEQQSIKLTDITDLRSQKVGDHVGEEDKKKHSMLISVKGTISYEKITLIGANNKKLLSFYTDTQVNKYVWLDGLKMLKGIIKPGQLSSDTEKQLDALVDIRRNTQLMNLEDVKSVNQVTFRETSGSSSDDEDYYDINELTTVATDKYYYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBI4</accession>
    <name>G3BBI4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_107700</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBI4"/>
    <dbReference type="STRING" id="590646.G3BBI4"/>
    <dbReference type="eggNOG" id="KOG4774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066684_2_0_1"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="8">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="159" mass="17634" checksum="04C3B67DB73EA38D" modified="2011-11-16" version="1">MSCNKDDCCQSDSVCERNEVPNDVEGIYESVDASDDVWGDSDGEDDIITKNSSSTAEIKRVHTKQGYLDGLSNAKESSLQQGFDDGYPKGGELGIMVGRILATVLSYDTELFLQCKQELIISKVLNKGYFNSNLDIEDLEAHEVLQKWLKICSDLIPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBT9</accession>
    <name>G3BBT9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative lipase ATG15</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Autophagy-related protein 15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Putative lipase atg15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTEDRAFT_108669</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBT9"/>
    <dbReference type="STRING" id="590646.G3BBT9"/>
    <dbReference type="GeneID" id="18246052"/>
    <dbReference type="KEGG" id="cten:18246052"/>
    <dbReference type="eggNOG" id="KOG4540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028295_0_2_1"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="22">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="469"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV62826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="544" mass="61276" checksum="3A2A30DF9CA350E7" modified="2011-11-16" version="1">MLLVGRTRIPALGDLPSPAIHPSPSNDQFQLKHIFHHGAGSQHYQIHRRLDITPEFLAATGLDDVQMSSDKSDIHTSDLEQVYAQNDWPEAFQNRNPWTMRFPIKSGPPVKVQRLAERHTPNFIDSYLEYAINIKGNPRLLNMINLEWEQPKEISFPDVSDKDTLVSLALISSNAYVRFPKSEEEKRKSDWTDLGEEWQPDQNNSDLEFGWDGEGLRGHVFVNEENHTVVIGFKGTSGAGIPGAGEDETTASDKLNDNLLFSCCCARLSYLWTTVCDCYEKAYTCNQDCLEKELVRKDRFYQAVLDVYRNVTAMYNPDVYDIWLTGHSLGGALASLLGRTYGLPVVAFEAPGEMLASQRLHLPQPPGFPRYLEHIYHIGNTADPIFMGSCNGASSSCNAAGYAMETACHTGKLCVYDVVTDKGWNVNVLNHRIHTVIDDIILKYNDTPECVVQPPCRDCFNWRFVSHDDDEDDEPKLPNPLLPHRSKSRTSTFTSASTSVNMGFETSVSSQPPQSSTSQPPKKQKCLKRAWYGWCSEWGDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCN7</accession>
    <name>G3BCN7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116903</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690493.1">
        <property type="nucleotide sequence ID" value="XM_006690430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCN7"/>
    <dbReference type="STRING" id="590646.G3BCN7"/>
    <dbReference type="GeneID" id="90981751"/>
    <dbReference type="KEGG" id="cten:90981751"/>
    <dbReference type="eggNOG" id="ENOG502S7B4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056574_2_0_1"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF1">
        <property type="entry name" value="COLD TOLERANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="258" mass="29267" checksum="FC9C87AA9B3287E3" modified="2011-11-16" version="1">MTLIVVDFDETITEHDTISLISQIPYTTDPTKTPPFEYFTNVYLQALEKYRSVANIPKSMAEEIEYQKGMKSVEMSSINELERHQLFNGITKQSLAEQAVKVKVKPGFSKFLSICSSRQIPVKILSVNWSSVLIRGVLAGLGYELDVMVNELQFDGHSVCTGHFDPTISVRTGYDKYMAIEQLKRQYHNQKLIYIGDSRTDLLALLASDMGVIMESGSLIQKLPWDIDVRQLSGGSDIHGLYTSNWYHINEFLELNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCP1</accession>
    <name>G3BCP1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-lactate ferricytochrome C oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_128518</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCP1"/>
    <dbReference type="STRING" id="590646.G3BCP1"/>
    <dbReference type="GeneID" id="18249312"/>
    <dbReference type="KEGG" id="cten:18249312"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_3_3_1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF117">
        <property type="entry name" value="AER321WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="138"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="572" mass="63891" checksum="D5E6B0836CF5AE0A" modified="2011-11-16" version="1">MYLRGDDFREPKGQMSQSHRELTSRDLCIIVYNSNHILMSRYLFSRTAAVVGAVAASSFATYTLTRAHLQSNLPSDWFPNESTTKLHSISTPQYATPSQLQHAIRELRDVLGDTNVVNTPVVLEYHTRNEFNPHEPKPHEKPKYVIYPRSTNDVSEAMAILNRYRVPVVPFSGGTSLEGHFYSTREGIVMDTSKMDQVLAINSEDLDVQVQAGVNWVRLNEQLAPHQLMIGSDCGPDGLISGMINTNASGINASKYGAMISNVISLTVVLPDGKIVRTKQRPRKSSSGYSLTQLFVGSEGTLGIVTEATLKLHPIPRYETVIVGQFPTLLDSTKTVSQLYRAGVHPNAIELLDRDMMHCINYSGYFTQEWAEVPTLFFKVGGMSKAMVDEQVKVLKEISVKNNCKDFIAAKSEEEGKELFSARKNAFYAILNYGRNEIDPDIRLWVTDIAVPLSKLPPVLDQIYAMIRESGFQSVILAHAGDANFHCDVFYKDHEKDKCESLINKMMDLGLVNEGTASGEHGIGNGKRTFLIQELGQDAVDLMRRIKLAVDPNRILNPDKIFKIDPNDKGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCR9</accession>
    <name>G3BCR9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">CANTEDRAFT_100172</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCR9"/>
    <dbReference type="STRING" id="590646.G3BCR9"/>
    <dbReference type="GeneID" id="18245366"/>
    <dbReference type="KEGG" id="cten:18245366"/>
    <dbReference type="eggNOG" id="KOG3339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064541_0_1_1"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="228" mass="25463" checksum="2211C44122D77450" modified="2011-11-16" version="1">MEYETRILVRSLLVVLPLFVIVSRLIFVLPSVNSPVINDRADGAELPSWLSGSNIMIFLGSGGHTGEMMSILSKVNLTQLNRIWVVSSNDSTSILKCKEYEDTLKTNTAPSFISLLRARDVGEPLLSSLKSTIRSFIDTFLKLRQLPQLPDVLLVNGPGTSVPIAYMLFLFRFLGVGNTRIVYIESLARVNDLSLSGKLLLPITDRFIVQWPAVANRYKRAEYYGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCX3</accession>
    <name>G3BCX3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116279</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCX3"/>
    <dbReference type="HOGENOM" id="CLU_2084566_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="117" mass="12922" checksum="A5E784990374D4D3" modified="2011-11-16" version="1">MTTAVNTKRIDECDESIDRIAAYTGNDAEWLLHVKNVNERLRFLRESYRLVANFRKRQIRQQAGHGSGDLDDGNTTMVTDPAQMNLEGVISDDDEGSSTTDAASGLRSTSRRGVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCY8</accession>
    <name>G3BCY8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116295</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCY8"/>
    <dbReference type="STRING" id="590646.G3BCY8"/>
    <dbReference type="eggNOG" id="ENOG502S7IA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1474985_0_0_1"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="183" mass="21621" checksum="5D124D6B986277DF" modified="2011-11-16" version="1">MLRMFTRGVSRSAKDTLLTAPTLKQKLAKEEKIFQKNLPEWTKRDKSVKLRYGSWNPSKKLNRQQIQDIRNMTISLPNIKTVELASMFRVSPEAIRRILKSNWVPNESDEEKLLEREEKRRLEKAQRRQEEREQVRKQQQEYSGRGRAPGANSGRNTGQKGPRHTQQRRPARTFHRDMADIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD03</accession>
    <name>G3BD03_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_110683</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690100.1">
        <property type="nucleotide sequence ID" value="XM_006690037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD03"/>
    <dbReference type="STRING" id="590646.G3BD03"/>
    <dbReference type="GeneID" id="18246213"/>
    <dbReference type="KEGG" id="cten:18246213"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_3_0_1"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="133"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="241" mass="26251" checksum="87844095658BDF5B" modified="2011-11-16" version="1">MFQTLSAKAAIQLDQELMSTGAFSIDQLMELAGLAVAQAVYKEYPPVTINDKVLILVGPGNNGGDGLVAARHLKLWNGYEPVVFYPKKTAKPLYTNLMTQLKHLGVSEVTELTEVKNLLSSGQVKLIIDSLFGFSFKPPIRAPFDDLIKYLCVNHDKIAPIASVDIPSGWDVSDGPVGKDMDIKPSMLISLTAPKPCAVIAHTQGVTHYLGGRFINGQIAAKYHIEELIAKYKGNDMVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD11</accession>
    <name>G3BD11_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF625-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_128630</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD11"/>
    <dbReference type="STRING" id="590646.G3BD11"/>
    <dbReference type="eggNOG" id="KOG2175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004909_4_0_1"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="82"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="227"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="670" mass="76396" checksum="89FABDA7EFEA958F" modified="2011-11-16" version="1" fragment="single">MASAMVMTTNGNGRVKQEEQNDVVHPSQESEQHNPTPSKSQDHPTWENHNENDKQQSHSPHNESTNEVKQEVIDTIGTKMQRRVKVYLLKEDSWLDHGTGFCTGEIDRDTQKPYFLVRNELNLEEIILKAFLEGSTQYQRQQDTLIVWTDPSGKDIALSFQETEGCADLCEFIVKVQQDSLSPDISLYYVISSNQADENGNSGDITELITGPMVYPDLPTTSNLEDVLDTLNQSSMSNYSKSCMSKYLIDKSYFIKILEAFKQSEDEHNLINLYSLSEIVKTLILYSESAILQDMLSTEENILGVIGILEYDAEFPNQKSCHRQFLKEKANFKMVINLPVENDELGLNIFKKDFYYTFLKDVILARFIDDQTYNLLNALIHLNQIALLDFLRDSEKNNHFLEKLFDFYKGTGDEVDITLQRNGVKLLHQYVLLTKNFASNQRTMFFSELISHGLIDMIKFSLNDDDSPIKALGTELIVSIIEQDVSLVNSINDGESIDNSEPPMDYASTIEAKQPDQSKDESNQEKDIGLKLSDDMTLMTLLTQLLLNEKNFGLKTQAFEALKVLLDQNIGKIDENGAIPDYGASNSSGSDISTEDYFKAFYSEVAPILYKNLIELGNTKEVTEELKHKIKSDELLYQQLCELFSFCLLTHNKNLHRRFFLDQNILLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDA7</accession>
    <name>G3BDA7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_95736</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689497.1">
        <property type="nucleotide sequence ID" value="XM_006689434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDA7"/>
    <dbReference type="STRING" id="590646.G3BDA7"/>
    <dbReference type="GeneID" id="18250535"/>
    <dbReference type="KEGG" id="cten:18250535"/>
    <dbReference type="eggNOG" id="ENOG502RZ2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006926_1_1_1"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF39">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="738" mass="84132" checksum="5836589DADDB5013" modified="2011-11-16" version="1">MSTVSKPRPLKVYGRAHYACTHCKSSKTKCSGGHPCSNCKNLNRAESCIYPTRDRKIVIMESDLNKLHDQVKYWETVFSGGTTGGQRPDSFADIEPSRANNIIQERLNEETKEFLFNSQGLEDYLVSDDANETIKWKLLTFISERIPSRDVTQRLIHTVVDNYANEFYLVDQTAYPEIVDNVYMLLDAINNKQETIARRLNSKVKRYHLCYFFSLIAYGEQISNSITSHDAIPGMQFYMLGSELLNLTHEVVGFEFIQASILLALYSANLNRYNTVYNYFGVAIRSAISQGFHRQPTHSLSTDPDLLVRNEKSKRLWWTVYVTDATWTAKLNLPSQIDYSETDVDLPGENSIDLADGFELNLLDVNVQLAKHISKSVEKIYGANMRTFSVNYINTDQFTRKTQIQSVMTCFKEVVKDFEVPYLFQYKNCNVIEQLGRKLVNLFLRFNLLIAMISKPLISLIFNTSHTSIFDEPAEVEIIVNRAIASSIANINLLIKLYEVDRLFTIGFFDSQYLFTGLLIIIMSSITDRHCLEIVNKAIALLRHMANSGNINAKNAMKKLAQVNDFLSKTPEIDFSLNLDLDIRDMVPVSKSFDIQSHYYNPYEDFSCSSLANFKIYKPTPPIIERPASLRVQMLNPNTELKNHQIQSRIEESAASAGDEEANPPAFFASSVPVNESVAPPNIRENDYGQSNSFYNYNYDELSPDVFTNNRVSNLSGASQNTLLTMMNNLQSQDYINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDC4</accession>
    <name>G3BDC4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_116985</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDC4"/>
    <dbReference type="STRING" id="590646.G3BDC4"/>
    <dbReference type="GeneID" id="18248530"/>
    <dbReference type="KEGG" id="cten:18248530"/>
    <dbReference type="eggNOG" id="KOG2965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_6_1_1"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="317" mass="34288" checksum="A29CAFED0A619122" modified="2011-11-16" version="1">MSDVIYKYHPHKKATIITAPFSGGQPKGGVELGPEYILNSGFAKQIQDLGWDVEITHPLEGTDFEAAKNDEKDSFGVKNAKIVSDCNRKIFAAVHTSLQNQRLPITIGGDHSIGTGTLLGALTNNEDTCILWIDAHADINSPKTTGSGNLHGCPVSFLMGIDRESYPPEFDWIPTVLKSNRIAYIGLRDVDSGEKKILRDHNIPAFSMYHIDKYGIGKVVEMALQKINPNMDFPIHLSYDVDAIDPSFVPATGTRVEGGLTLREGLFVAEEVAATGLLSSIDIVETNPSLGETSDHILDTVSAACAIGRCALGQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDG1</accession>
    <name>G3BDG1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_136776</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDG1"/>
    <dbReference type="STRING" id="590646.G3BDG1"/>
    <dbReference type="GeneID" id="18250000"/>
    <dbReference type="KEGG" id="cten:18250000"/>
    <dbReference type="eggNOG" id="KOG0123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_22_4_1"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000008">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000211">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000520">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000648">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="139"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="232"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="335"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="559"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="457"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV60292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="647" mass="71121" checksum="F0B20841275D3DB9" modified="2011-11-16" version="1">MSSDPTQIQESLEKLSLDNKEQPPKESTEQSKETTTETSAPAKENLGETSASLYVGELNTSVNEALLFEIFSPIGQVSSIRVCRDAVTKKSLGYAYVNFVKFDDGEQAIEDLNYSLIEGRPCRIMWSQRDPSLRRNGEGNIFIKNLHPAIDNKALHDTFSAFGRILSCKVATDELGNSKCFGFVHYETAEAAEAAIENVNGMLLNDREVFVGKHVSKKDRESKFEEMKANFTNVFVKNLAPEYTDQELKELFSAYGPITSSYLEKDLEGKSKGFGFVNFDNHNDAVKAVDELNNKEIAGQPIYVGRAQKKRERMEELRRQYEATKLEKLSKYQGVNLFIKNLDDTIDSEKLENEFKPFGNITSARVMVDEQGKSKGFGFVCFSSPEEATKAITEMNQRMVEGKPLYVALAQRKDVRRSQLEQQIQARNQMRMQNAAAAAAAAGGAIPGQFMNPMFYGQQPGFFPPPGANGGRPNGANGAGPNAGPNANPQMMMAAAAAAARGGQIPPPQAGAGWGRPNPNGQQIPPVYGMPPVYQNGPNGQPRGAPAPGMYPPNGRPTKARDLAAILSSVPPEQQKRILGEELYPKIVSTGRANEPEAAGKITGMMLDLDNQEILSLLEDDELFNNHFEDALTAYEEYKQSNEEGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDJ4</accession>
    <name>G3BDJ4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TBP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116365</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDJ4"/>
    <dbReference type="STRING" id="590646.G3BDJ4"/>
    <dbReference type="eggNOG" id="KOG3302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_4_2_1"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="237" mass="26036" checksum="04618F6A4E21188E" modified="2011-11-16" version="1">MDSLKLPVTPAKAKAFTGPDSLSYPSGISGQQQTGLTKKEETDGIIEPKTESEDGSALGIVPTLQNIVATVNLDCKLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSENDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYAAFEAIYPVLSEFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDK9</accession>
    <name>G3BDK9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Nuclear transport factor 2</fullName>
            <shortName evidence="3">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_116377</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDK9"/>
    <dbReference type="STRING" id="590646.G3BDK9"/>
    <dbReference type="GeneID" id="18248273"/>
    <dbReference type="KEGG" id="cten:18248273"/>
    <dbReference type="eggNOG" id="KOG2104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131642_0_0_1"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="4">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="124" mass="14211" checksum="88068F62C40023C9" modified="2011-11-16" version="1">MSVDFNTVATEFCNFYYQQFDSDRTQLGNLYRDQSMLTFETSQLQGAKDIVEKLVSLPFSKVSHRVSTLDAQPASPNGDILVMVTGELLIDEEQNAQRYSQVFHLIPDGSSYYVFNDIFRLNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDT4</accession>
    <name>G3BDT4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_116427</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDT4"/>
    <dbReference type="GeneID" id="18248301"/>
    <dbReference type="KEGG" id="cten:18248301"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="203"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV60376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="485" mass="54800" checksum="1C180D405BF4C1D9" modified="2011-11-16" version="1">MSAVSKTRAEPMKIKGVAIALIPTRLETAVTVGYLVVVIICAGCEIKYYPREMVFASKTQALARYIAVRTGILASFSAPLLILFAGRNNFLQWATGWNFATFIAYHRWVGRVVFTLVLVHAVGYTITFKGRYAEEMAENYVIWGTIATVAGGLIMVQGLLVLRRRSYEIFLFLHIVLAALFIGGAWLHVDTLGYINWYYATTAIWCVDRVVRVIRLVLFGFPVSTVQLVAGETLKVITPKPSYWKSVPGGHAFIHFIRPSCFWQSHPFTFTEAVETNDKIVLYCKIKGGVTHGLYKHIASQPGQTVKMRVGIEGPYGEPTAAKYCDTAVFVAGGNGIPGIYSEAYDLARRDSKQKVKLVWIVREYKSLDWFYEELQFLKGKNIETIVYVTRPINQAADSDQEKKKTEDSDESSFKAAEDLCHVEFRHGRPDVEDFVKHEIDESNGSIGFVTCGHPEMVDHLRYVVSHNLSEEKRIEFYEQLQVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE44</accession>
    <name>G3BE44_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_99867</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE44"/>
    <dbReference type="STRING" id="590646.G3BE44"/>
    <dbReference type="eggNOG" id="KOG3954">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="262"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="279"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="330" mass="34428" checksum="2A03CA152C43399B" modified="2011-11-16" version="1">MPSNIVFKRGFASTVYKLDTLAFVESAGGKISPSSLSSLNAANQIGKPVTAVVFGPGGESIAADVSKIPTIQKVIQVKGDKYEHYLAEELAPTLKEIIQSSSYTHFLTSASAVGKSVLPRLGALIDSQPVSDILKVVDDSTFVRPIYAGNALATVKSNESVILASVRASAFTPVDATGGSAAIEEFSSSAESGSRTEFVSEELLTSERPELGSATRIVSGGRGLKNKETFDELLEPLATKLNAAIGASRAAVDSGFCDNSLQVGQTGKIVAPELYIAVGISGAIQHLAGMKDSQTIVAINKDPESAIFNVADIGLVGDLNQIIPELTEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE69</accession>
    <name>G3BE69_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_111853</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689687.1">
        <property type="nucleotide sequence ID" value="XM_006689624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE69"/>
    <dbReference type="STRING" id="590646.G3BE69"/>
    <dbReference type="GeneID" id="18246315"/>
    <dbReference type="KEGG" id="cten:18246315"/>
    <dbReference type="eggNOG" id="KOG1061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006320_4_4_1"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="701" mass="79596" checksum="8680F6CC97A58047" modified="2011-11-16" version="1">MSDGKLFVKSKSSEIKAELDQAYKRGKPHAKIKLILKKVTANIILNNNEISKLLPDMINLLRFDDLEIRRVCLDFLCFYSHYDPKTALNAVPFLKRFREDSDSILRALTIKTLTSIELPEFTDLSFSVIKLYLKDPNVYVRIAAAYSTARLFKFSTSRVINENLIDSLNDLLYDEDDTVISVALSALDSIIEHDKTLDLKLTVNPSHSIKLLKTLHRTTEWSQVYILNSLLSFVPQHTNTALDLIELVIPFLQHENSSIVLNAVKVIVYLSNYVKDPELILPSLPKRLGSSLVSLLSKPPELQFLVLRNIILLLLGRKYLVQFDVEMLFCKYDDTIYVKDTKLEIIYLLANEHNFSTVTRELEEYATDVDVAMARKAIRAFGNLAIKITSAASLCVEIIIDLISNKVSYIVQEAVVVIKNIVRRYPGDFDYAITEMAKYYKLMEESDAKAAMIWMYGQYHHLIEDIEEGYTTLIQSYKDEPLEVQLATLTATTKLYLHYPEKFERSVLAVLKWATEEVNNPDIRERGFFYWRLISSESGSDVNGGFQSVAKQVVFNENPRIDSENENINPAVLEELELNIGTLASIYLKPIALVFRLSKSRTLPHSQALQPRRPSKNSADNSARSSRATSTDNLALPEEGKIYSSRKFNVSADAISRKKSIIRQSSFDSTPSGLSDDSKKNGLARRLSKRASILTGRRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEB7</accession>
    <name>G3BEB7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavo protein WrbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116573</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flavodoxin-like protein (FLP) that plays a role in cell wall integrity, oxidative stress protection and virulence. FLPs act as NAD(P)H quinone oxidoreductases. Reduces ubiquinone (coenzyme Q), enabling it to serve as an antioxidant in the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEB7"/>
    <dbReference type="GeneID" id="18248358"/>
    <dbReference type="KEGG" id="cten:18248358"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="5">
        <location>
            <begin position="6"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="206" mass="22620" checksum="66F98B068C7F3458" modified="2011-11-16" version="1">MAPPKIAIIYYSLYKHVYKNALEIQKGIESAGGSAQVLQIPETLPPNVLQLMHAPEKPSYSEIPEAKVSDLTEYDAFVFGIPTRYGNFPAQWKSFWDQTGSLWAQSKLHGKPFGLFVSTGTPGGGQESTFMNALSSFIHHGMVYVPLGYGEAFPLLTNLDEVHGGSPWGAGTFAGADGSRQPTELEKQIHQIQGKNFYKTLEALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEP8</accession>
    <name>G3BEP8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_99508</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689159.1">
        <property type="nucleotide sequence ID" value="XM_006689096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEP8"/>
    <dbReference type="STRING" id="590646.G3BEP8"/>
    <dbReference type="GeneID" id="18250865"/>
    <dbReference type="KEGG" id="cten:18250865"/>
    <dbReference type="eggNOG" id="ENOG502QSRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598506_0_0_1"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV59945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="50426" checksum="33CE76E90B4D2615" modified="2011-11-16" version="1">MVKVPCPVTVELEPTQTSLVIGCPGVPRSVPRIETKLLIRSINGQPFTLRSVGIELRTTQRVSIPSTLGSNESTQEYKLYEDPFVFNPTFGNFTAENLIGLDLPVLISLPKDIISSGYNLNWNASTVHNLIVRVMVGESAETETGFMESFPIAVKLYDALPIYRQFTESINESVISGDQQLIVEYKLQESCLGPGDSLNLAVKIMKNSLNYNVSSKLRVKTLNFQLKEVLECHEGGLPPYKDITIIEDLKDGKELNLNNEISLNYGFKLPTNSDFLSIFDKNESSLQKYTYFDSYQDNVPVHIDNHMNHKQNQVKLIEGIPMTHYQNFTTVGKLFSIRYEILLKLKLVHGKDFTVRIPIVLSPYNKTSSEYLLNWIINQCKISSEIFGKTLINQLAQSYNTKDSTSSLSRFKAPLQIYKSNRNDWVKLGFSFDSFGTPQPIGSYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BES4</accession>
    <name>G3BES4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116661</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689793.1">
        <property type="nucleotide sequence ID" value="XM_006689730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BES4"/>
    <dbReference type="GeneID" id="18248393"/>
    <dbReference type="KEGG" id="cten:18248393"/>
    <dbReference type="eggNOG" id="ENOG502T1UR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636194_0_0_1"/>
    <dbReference type="OrthoDB" id="4097096at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="35"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="379" mass="42951" checksum="74FD58BD26443252" modified="2011-11-16" version="1">MSISDKHPHDPTLDNIEYDYLPSLDQFLNDAFLFSINQVKSQPKIDFINRFNHFTSSLHCLENLQFLVSIYHYEFSYNRIFNTAPQLNPNRNSVVTVESIDTLDNLPINYFASTIDDIDASGENCWTEFMERQLEDDNDDEDDQDMDSYSSATTTLCSQWQYLVDNFICPTSKYQVNLSNSTCKQLLSIKEKYPSPLVLVAAKKEVMQLLEENAFHRFIKEYKSYNQVPCEDCNCGMQSQPEAHTEECPREVQPLYPESQAVKKPFLKKSPTLNPFKFSRPSSPLSINSASITPTNSTPQSHNSVLNRKKTKSYSLLASGNTSPSHSGTSLSNLLSHLKFNKSSNSSSNTSIANSLNTSHNTSPIDDGKKFKFSDKNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF63</accession>
    <name>G3BF63_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116709</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF63"/>
    <dbReference type="STRING" id="590646.G3BF63"/>
    <dbReference type="GeneID" id="18248412"/>
    <dbReference type="KEGG" id="cten:18248412"/>
    <dbReference type="eggNOG" id="KOG2803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031246_0_0_1"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="214"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="379" mass="42760" checksum="58C7384F8863AF89" modified="2011-11-16" version="1">MFSRPEGIENTRIWVDGCFDFTHHGHAGAMLQARQLGRELYVGVHSDEDILQNKGPVVMKLAERLTAVEGCKWATKAIPDAPYVTAPDFMDKYGCKYVVHGDDITTDANGNDCYQEMKDLDRFVVVKRTPNISTTDLVGRMLLSTKTHHLPAIKSMGHGLFSNENVAQFEKYATDQGGLHPHAGVYVHLDDDPLHVLVQPAQEVNQTYQKLVYVDGGFDLFHPGHIEALRLVKQHANHVGAAVMVGIHDDKCVNDHKGLNYPIMTLFERSLCVLQCKYVDGVVLAAPYNADRQFLDRLPGSVVAVMHGPTPVDPEVYADARTDGIYQQMGSHKFDDINTQFIVKRVLDNMEAFEERQRKKGWKAENERRLEELERQKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFA3</accession>
    <name>G3BFA3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_110717</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFA3"/>
    <dbReference type="STRING" id="590646.G3BFA3"/>
    <dbReference type="GeneID" id="18246217"/>
    <dbReference type="KEGG" id="cten:18246217"/>
    <dbReference type="eggNOG" id="KOG2411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_4_1_1"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="191"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="686" mass="78211" checksum="DA7349FF0DA47E1C" modified="2011-11-16" version="1">MRNWATAKRFPRTIRYPSPNPVSLQWTRSYSTEFPPKEVTVQKFTFPLASHSVKHISNNLDKFLQGNPVTLNGHLNRRPRLMAKHAFAELRDSNGDTIQMMLAHGVTPEKYFGVVEKSIPEESISVSGKVQLKQSRSGEREWELLVENYQVLNQSNLDAARLDKLKHSSPKDLPPQFRYLQLRTPHYQNNIRTRSKIANLIRNTFIQNHDFVEVETPLLFKSTPEGAREFLVPTRKPNAFYALPQSPQQYKQLLMSSGITKYFQIAKCFRDEDLRADRQPEFTQVDLEMSFVSHSDQVGVVVEDVVHRVWKDIAKFPVYTINKNGNLEEISEFSTHKINFTKVPYIEALTKYGIDKPDLRSSLSLIDLSGFFTPLKNTNFPVLEACVLRDAFDPSKKFKVPKALSDSNSYSRRKPIVIPIKTQPDASEWYKNFVEKHLITPTSSFNESQLESTLNLHPGDILAFADRAELPYENPTPLGKFRQLAINEFPNKWKRMIELSNGDLTDNYCTKDMVVASWVVDFPLFAPTESGGSPSDEYPTYELSQLESNHHPFTMVKLEDYDLLETDPLKVRGEHYDLVINGVEVGGGSRRIHDADLQKYVFKHVLGIHHYNDLFGHLLHALSMGCPPHAGLALGFDRLCAMVVGSPNIRDVIAFPKNQSGVDPIVESPSSVPEKTLSEYFITTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFE8</accession>
    <name>G3BFE8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116727</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689885.1">
        <property type="nucleotide sequence ID" value="XM_006689822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFE8"/>
    <dbReference type="GeneID" id="18248423"/>
    <dbReference type="KEGG" id="cten:18248423"/>
    <dbReference type="eggNOG" id="ENOG502S1BQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105114_0_0_1"/>
    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05234">
        <property type="entry name" value="UAF_Rrn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="183" mass="21348" checksum="F569A4EEBE0D880D" modified="2011-11-16" version="1">MHQHSIYEVCNDQFVQNRIVDDSVKRRNIQGVSVKNHTVVVDLDKYRDPLEDILRTKGVYVSPDEMFRSSPNMVVDVPFQSREEFEDLELPDSELLKVLHYYVSNRSANQGWRLEKKLDETALLAFGMLVEKWADDIVDENVARMFIEQQTRDNKRLPVDGDEVEDETAQDAEVVQEALRAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFG4</accession>
    <name>G3BFG4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_116744</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COX20 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFG4"/>
    <dbReference type="GeneID" id="18248427"/>
    <dbReference type="KEGG" id="cten:18248427"/>
    <dbReference type="eggNOG" id="ENOG502S3BD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125578_0_0_1"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007871">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="172" mass="19607" checksum="BF07E86FFDA087D0" modified="2011-11-16" version="1">MGWFGGNTVKSTPVTQVPEGNPQKFLEDLPPKFEDQGDVPGDASDQSMYEGALSQVRLADVKPSTYIGMPCFREAMMTGFQAMAVLGGVTFLIHKNPNKSLNWGVCGFFLGNIVGWEQCRSIRRKSFETVEKARQVKQQKNEQKWEDKASNTKDERLEKWRQVQEHYESKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFL4</accession>
    <name>G3BFL4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116072</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFL4"/>
    <dbReference type="HOGENOM" id="CLU_1408569_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="193" mass="21279" checksum="3B6E97AD4D0E653A" modified="2011-11-16" version="1">MAGVFMALPIHTNRKNRLVNLYCRYTVWLSMEERRLQVTAVVRAGKFHVESVDGCNNRVYKAIKTRNSAQTRQNMVGENRIHKGHQNRRVDEAHLKHVDVGGVGGVIQDPSKGIADVVVAQHQAASAVKQPHLKQECHHAGCSERRCVDRANQKCVFGVGYQNVVDPVVQQEPGVSDVLGVGSGAEVVQGLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFQ3</accession>
    <name>G3BFQ3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Snf7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116102</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFQ3"/>
    <dbReference type="STRING" id="590646.G3BFQ3"/>
    <dbReference type="GeneID" id="18248166"/>
    <dbReference type="KEGG" id="cten:18248166"/>
    <dbReference type="eggNOG" id="KOG2910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086201_0_1_1"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24380" checksum="6B7A280E129438D7" modified="2011-11-16" version="1">MGQQPSTPKITAQDRAIFQMKQQRDKLKQYQKRLNVVVLRQTNLAKEALSKGDKERALFYLRSKKQQQSVISKTYEQLDNLENLIGTIEFKLIEKDVVYGLTQGNQVLQKLNTEMSVDKIDKLMDEVEDERLKVDEVSEILGTKNALSNSEELEVDEEFERMDREINGTVQLPDVANDTHKVSFPETPSTELEPEEAQKEEQQNTPNEPLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW08</accession>
    <name>G3AW08_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_112155</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW08"/>
    <dbReference type="STRING" id="590646.G3AW08"/>
    <dbReference type="GeneID" id="18246376"/>
    <dbReference type="KEGG" id="cten:18246376"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_1"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF48">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="320" mass="34942" checksum="927DDF66632AAC68" modified="2011-11-16" version="1">MSTNSIKLLASDVHKGLAELVAKRLGLKLTPSEIKRDSTGEVQFSIGESVRDEDLFVICQIGSGVVNDRVIELLIMINACKTASARRITVILPNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNLYAEPSVVRYIKEKIIFQQAIIVSPDAGGAKRAAGLADRLDLNFALIHKERARANEVSRMVLVGDVTDKICIIVDDMADTCGTLAKAAEVLLDNGAKEVIAIVTHGILSGKAIENINNSKLERVVCTNTVPFEEKLKLCSKLDTIDVSTVIAESIRRLHNGESISYLFKNAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW60</accession>
    <name>G3AW60_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_128871</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW60"/>
    <dbReference type="STRING" id="590646.G3AW60"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_2_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442605" evidence="7">
        <location>
            <begin position="19"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="376" mass="41625" checksum="61BFF9ED2D6A9350" modified="2011-11-16" version="1">MHFFILLLVASLLALAQAKDYYKILDIGKDADDKTVKSAYRRLSKLYHPDKNPSEEAHERFIEVGEAYDVLSDPQKKKNYDTYGDPNAQPDNRIDLGDLFSQFFGGGGGGGGPMGGRGGGGNARRVRKGENKLAAVDVPLKDFYTGIDLNFSLQMKAICSGCEGSGSKDKQRHPCTKCGGQGIVQMRRQLGPGMIQTFQVQCDECGGKGTVIKHKCSRCHGAGVEDVKKDFSIYLPAGLERNHHSVIEGEGDENPDWTPGDVIVNIQEDFKDTWGYRRVGHNLYRTEVLTLAEALEGNWSRTIPFFDPVDPEIHLSRHPQQVVVNNEVEVIKGRGMPFVDDDDSHGDLFIEYKILVPETPGAPEPRFATEIAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW95</accession>
    <name>G3AW95_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112206</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in DNA replication and cell separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SDS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW95"/>
    <dbReference type="STRING" id="590646.G3AW95"/>
    <dbReference type="GeneID" id="18246401"/>
    <dbReference type="KEGG" id="cten:18246401"/>
    <dbReference type="eggNOG" id="KOG1764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024459_1_0_1"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018148">
        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="213"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="288"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="476" mass="52913" checksum="5816E54BB3A36FFB" modified="2011-11-16" version="1">MSNFQRSIPTSPKTTSSAISPNLSHERNPSISSQHHTHKHSIGSHLPPSSSQASSRKPSIVEMLSSPPPLPANPFPNNDDINSFNLSRNNSLSSRSSMDMHEVQLTELIESNRLITINSSYSIQKAFETLMEHSLTSVPVITSPDPRDLTNCLTFDYSDLNTYILMIMNKIRYQDLTVGGAGSDTDITAEVFDSYVEKGKKGEEVPVTFIIALHPKNPFVKINENDSLVSVMEILGNGVHRVALVNNIGHIVGILSQRRLIRFIWDNARRFSNLEYYFNQSIEDLKIGSSNPLTIYGDSLLIEALHKMFVERISSLAVIDRKGNLVANISIVDVKNLTSSKNSHLLYKSVMNFIGFNLSQKGIEEGKDQFPIFHVNRHTGLGRIIAKLVATESHRLWIVDPPNQSTIEDTLSFDGGLPGKLTGVITLTDILGFLASIKSNGKKIDPSYARNQRRRSSTSTTRSSFDNSSSSEIFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWQ7</accession>
    <name>G3AWQ7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_112307</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573</strain>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWQ7"/>
    <dbReference type="STRING" id="590646.G3AWQ7"/>
    <dbReference type="GeneID" id="18246462"/>
    <dbReference type="KEGG" id="cten:18246462"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_1_1"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="17">
        <location>
            <begin position="23"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="18">
        <location>
            <begin position="384"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV66837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="504" mass="55573" checksum="372518E51456C5B9" modified="2011-11-16" version="1">MSTSSLSWLTKLNTTETPEKNLRRSSIIGTIGPKTNNVETMVRLRKAGLNIVRMNFSHGSYEYHQSVVDNARKSEQVYSGRPLAIALDTKGPEIRTGTTIDDKEFPIQPNHEMIFTTDEAYAKKCNSEVMFVDYKNITKVIKAGKIIYIDDGVLSFEVLEVSDDKTLKVKSVNAGKICSHKGVNLPGTDVDLPALSEKDIADIRFGVKNGVHMIFASFIRTGEDIKQIRKVLGEDGKDIQIIAKIENQQGVNNFDDILAETDGVMVARGDLGIEIPAPQVFVVQKQLIAKCNLAAKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPFEAVSMMHNTALIAEKAIAYQTVHNELRSLAVRPTPTTETCAIAAVSAAYEQDAKAIVVLSTSGLTSRLVSKYKPNVPIMMVTRNERAARYCHLYRGVYPFVYPNAKVENWQEDVENRLRWAVSEAIDLNIIKKGDSIVTVQGWTRGSGHSNTVRIVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX27</accession>
    <name>G3AX27_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_129039</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683932.1">
        <property type="nucleotide sequence ID" value="XM_006683869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX27"/>
    <dbReference type="GeneID" id="18249358"/>
    <dbReference type="KEGG" id="cten:18249358"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_0_2_1"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="603"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="17"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="210"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="398"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="841" mass="98088" checksum="5F4A4BBE22B05BC0" modified="2011-11-16" version="1">MANQPEYDPLRGQQRVFTTQLVLCLWMGISSFLLFCFLRYRWPHIYAIRTLRNSNVILKAIPTSYFGWISLVLSVTEDEVLEYSGLDAYVFIMFFKMGIRIFFQLSVLAVFILSPVRFYYTGHFDKDDIPWRWPEAGVLFVRFVASGEFSGDDGSLPDFGDIDDFPHYLWVYPLFAYLFSGIVYMNLFDYTNRIIKTRQKYLASQDSITDRTIRIDGIPRRLLMQKNTEILKDFIEDLGIGKVLDINMIYDCQPLDQLLDVRKKLVRRIERYISSKHQLNIDIYNENCPTVSVRGQLVEDPKLMAYMEKLDNMDQEISEIQHTYKQRFDDNLILHKDPVFRQIPSAFVTMDSVASAQMAAQTVLDPRVYKLMVNLAPAPTDIKWSNLKLNYYTKIAKGYIITLIIILSYFPILFLVSSLATLLELKSISKFWPELGEFIKKSNWLTTFVTGILPPLLYSLLNLTMPYFYRYLSRCQGYTSNSDIELSSLSKNFFFIFFNLFLVFMITGTIWDYLSFIRDTTKIAFQLASSLKKKSLFYVDLILLQGLGMFPIRLLQIGDVVLLNLIGKIFFLNRFFLRTPRDYRFYYFTPPIFDFGIQVPQHILIFMIILIYSVVSTKIVASGLVYFGLGYLVYKYQLIYNYVHPPHSTGKVWPMIFRRLILGTILFQLFMCGTLALEGAVLLSILCFPLIVVTLVVIYNYEKYYLPLNNFIALRAIQSPLEFDKEFDDEVEEETASQDIETIPTLHVDMSDTDSMLVNGDYTVDYMSMSTPTRKRRISTLDEEREKYSNYMYPNLICDLDGPMVEFEGDRVALVRVAADEEMDSHRLILVTKNLVVSEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX39</accession>
    <name>G3AX39_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_91853</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683940.1">
        <property type="nucleotide sequence ID" value="XM_006683877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX39"/>
    <dbReference type="STRING" id="590646.G3AX39"/>
    <dbReference type="GeneID" id="18250118"/>
    <dbReference type="KEGG" id="cten:18250118"/>
    <dbReference type="eggNOG" id="ENOG502QW3C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458564_0_0_1"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF11">
        <property type="entry name" value="PROTEIN DSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="537" mass="59331" checksum="ED53BCA99F357555" modified="2011-11-16" version="1">MDISTDTTAVSENELLKSPLHQLELQTAKARANSPHSPTPASPLKSRTPPLSPSPAQYYPDRDHDHDRDSIYSFDSVSTNGRLLDRLGLESDDLLDTDEVTTLRLERLSISDVAGRPSSRHNSVQLQNPFRSPSIPHPNTNLTRLPSYRANHLFNIHPNLTRSGSTSRDKVFAVDPAHSPDRVLEGAELSPFSVKNGPGNIVYASRNRSVHSLKASFQPETTSVIGATGAISKKKSSVDYNEYDEFDFNSSSDSINASHSRIPHPGAGAMARTRSVSASVNSGSLSREGSTRRSISDYTNTTSSPNGKLAELSPEDRTKLSMELRGQGKQREASYQLQIAANPPFNYPKAMLLYALALKFGNGVKQNTPSSLKWLCRCILLCTNDTPEFASRVGILSQEELVKWGVSHIRSDTTEVDPIKLYDYYSKLPANQITKIVNTIKSQSDPLASAYQELGMFFLNGWGVEKDELLGIQCLSISSSMGNFNSMVQLGEIWGLKTRFHKKDNFKASAWLRLGEIFGAKTIGNSWIYKDKYLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXK1</accession>
    <name>G3AXK1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112135</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BUB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXK1"/>
    <dbReference type="STRING" id="590646.G3AXK1"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000035">
        <property type="entry name" value="Cell cycle arrest protein BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="55"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="328" mass="36980" checksum="B54A009230D036A5" modified="2011-11-16" version="1">MTTFRDHRDVQTQMRGRKKDPIEQFIGSPQILLDNSLSQLRYMILIEGLSIPPGYDSCPYRQSVWTILNRVAAFPTKDYMSLVSQASASLDEDVLQKITNDTFRTLMHDKAFHSKVSEPALIRILSAIAVTSNNGSSGYVQGLNVLLAPIAYTCHKSEPQAFAILHHLITKQIPLYVTPNLDGVHTGLSLVDMVLQIIDPALSEFFDSKFLKAEIYAFPSVLTLSACTPPLSSVLKLWDFLFAYGPHMNILFIVAQLINNRSSLLASSQPMELLRKFPPLEESEIIKLSLSFVPELPKKLFDMIVRHGYDPKVPHELKKFLHEKKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXL9</accession>
    <name>G3AXL9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_112520</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXL9"/>
    <dbReference type="STRING" id="590646.G3AXL9"/>
    <dbReference type="GeneID" id="18246558"/>
    <dbReference type="KEGG" id="cten:18246558"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_1_0_1"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="305" mass="34742" checksum="A306DE8ED268A48A" modified="2011-11-16" version="1">MVDLHTFKHPSVAVINGDHWFSEMNADSFPGQAFSLKIKRILHHAQSEFQDILIFESETFGNVLVLNGIVQCTEKDEFVYQELISHVPLMSHPAPKNVLVIGGGDCGVVREVAKHIKLGFVDNVTMVEIDDMVINLSRKYLPNMALPELFENEKVNFVIDDGFKFLKENTNKYDVIITDSSDPEGPAEEFFQTNYFRLLQSSLTPGGIVIMQSSENIWLNLDYLKQLKNKAETVFKNVKYTQCYMPSYTSGQLGLLVATDDEEKDLTRPLRTADNERELFRYYGAKIHESSFVLPTWVASELSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY29</accession>
    <name>G3AY29_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LACT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92085</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY29"/>
    <dbReference type="STRING" id="590646.G3AY29"/>
    <dbReference type="GeneID" id="18250155"/>
    <dbReference type="KEGG" id="cten:18250155"/>
    <dbReference type="eggNOG" id="KOG2369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016065_1_0_1"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="646" mass="72157" checksum="C3A6785181FF7420" modified="2011-11-16" version="1">MAKQVGKKDKKQSIEEVAVNEGETTHLHHKYHPSDSNSEPRILKKKLHQSRRVIFILGAVIGLCCAVFFSTSSERLLLNDLDNYVNFDSFSDFFGEWRDMVPASFQSMISDIKSQESDRQLHGSAESFSVGQRMASTLNLKSKHNVVMVPGVISTGLESWGSSTDGDCPSINHFRKRLWGSFYMLRTMVLDKSCWLKHIMLDPETGLDPENVKVRAAQGFEAADFFIAGYWIWNKILQNLAVIGYGPDNMLSASYDWRLAYLDLEKRDHYFSKLKAQIELNYLLSGEQTTLIGHSMGSQVIFYFLKWVEAKGEYYGNGGSSWCNTYLAAVVDISGSSLGTPKTLTALMSGEMKDTVQLNALAVYGLEKFFSRKERSDMCRTFGGIPSMIPKGGDIIWGNLTHAPDDPTNTLATENALLNDSVSLKGSKSESFGTFIRLKSEKTGDRNLSLTDSIDLLLDTSPDWFSNRVREQYSFGIAHTQEELERNNHDHSKWANPLEASLPNAPGMKYYCFYGVGNPTERAYSYHDAEKESNLSFTIDSEAADPVYFGDGDGTVSLLTHSACHVWKKNNTIYNPGKVSVTVVEIKHEPDRFDIRGGAKTAEHVDILGSAELNELILKVVAGKGDTIEDRYISELKDIVAGMPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYC7</accession>
    <name>G3AYC7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_129275</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYC7"/>
    <dbReference type="STRING" id="590646.G3AYC7"/>
    <dbReference type="eggNOG" id="ENOG502QR9C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034119_0_0_1"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="416" mass="46383" checksum="CD4604F181AB8B5E" modified="2011-11-16" version="1">MESSSKRSTRNNLASTTPDASFPSSSSLTLVTISSESNQCSCTMSGLLMSSSSGEPSLSTMESSLSSKILSRFWNSDQQSFNSQDQICGSTFSQPMVWDVAVTAKGVIQSDNTQVDSVLSNLYKYQNKALKVFSASTAGDTDIYNDDNAQVAWAFIEGYKVTGNSEYLQTAKDIVSFLMTQVDKNGGVIWHYKDDYIASISTIEAALAAIRLYGITKDKTLLTFTKTCLSFAYTYFQDPSDKLFYDGLSKSQYSDINKGKLTYTVGCALSVLSELYKYDSSNSDEWISKIKDLADATTYKLGAFYNGNGFWNNQMKYVHLLYVGFSDIFEMDYDFSSYKPEVSRQAAFIQGFLKDSDSMFFSSISRSTYTMVERYESSFNETVDQTEPVMCSGTAEKSLMDNASVLQIFYQMSRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYV6</accession>
    <name>G3AYV6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_129373</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684513.1">
        <property type="nucleotide sequence ID" value="XM_006684450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYV6"/>
    <dbReference type="STRING" id="590646.G3AYV6"/>
    <dbReference type="GeneID" id="18249379"/>
    <dbReference type="KEGG" id="cten:18249379"/>
    <dbReference type="eggNOG" id="ENOG502QRMC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019651_0_0_1"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="341"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="828" mass="95388" checksum="DF5449B92497AE4A" modified="2011-11-16" version="1">MEGWNLASNQFSGLSNSFSLGKTLLNYSDPNFSQVVAAKKALQLAFDSTGDETDKSVIELYLAACDGDLVTLENGVRKHKDLVNSLYPTESKGISLLIYSICFDNLNLVESLLNHGADPDLADSIIQYTPMMWAVYFNQLDIVKALLSSQADPYLSPKEDGRNAVSILNPDHTEMAEYFRLHNLNNHSQNKDDIYEGNSFGPGDEMDNLANEIRLQAITGDSSVSQELEDELKMDAYHEENELANDHVLVQLKEFEYDKVLPDEYLKFNDSDIPPLLDYIFDLRTQNITFQHDTKIPAAIIFQLVRYAHLKVNSDELTEFLFDCFIARLRAVTNTKSGVFNMIIQDDQSSVGGAGDIVLLSYWMSVVQFLHFYFCKNEIYKKYPQFLQELINIIQSLVSTLSFSINSRLNTLVEDCLLNFTNLVDVSNVLYAKDWNLFKSRKKLHSNTFDDIHDMLYPPTQAELMRPSPLKYIQTLGALDYVLNLHQVDNLVRFQCFSQVFYYINAIIFNKIIAQSKYCTRSKAIQIRLNISAIEDWLRSHNYKIFKPDKIGDLKSLLLSSQDTRFSLINLLDDTERANKRNPNNLIFYYNSIYFIGKTQLQPTIELLQFLQCMSSLDDEESLINTINQFDYLNYFQLLKVAKNYKYEVNEPKLPKSSINLLKRLIAEQGENQIKRINLSYMIQNKLLSKEYNIYINPNFVYKVSLPNLSESINNYGSGLGGIRVLRAKKFQPSLPIETLDDIDDLLTRNKNDLNDTFTYDQPDEERGEKEDEVDDDKPEENYHRNDPSLFRSKTDFKGDELFKQVQLPGSLAHKNWGEDDDIEANPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYW3</accession>
    <name>G3AYW3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small-subunit processome</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_101725</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684520.1">
        <property type="nucleotide sequence ID" value="XM_006684457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYW3"/>
    <dbReference type="STRING" id="590646.G3AYW3"/>
    <dbReference type="GeneID" id="18245493"/>
    <dbReference type="KEGG" id="cten:18245493"/>
    <dbReference type="eggNOG" id="KOG2172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003783_0_2_1"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="97154" checksum="BAD47F97918E64D7" modified="2011-11-16" version="1">MAKKTRQTGKSKAKRSNQKILNAFEIAERQENGSDSDGNSGDDDYRVQDGVLDASKFLNNAKKEDFSDDEIDSDEALGSDDDYDILNSKFSQSIRDKEKKLKSRAQRRRRGEKVESESDESDDGYSSIDEDQLVGLSEAWDMDDKDLAKSKMLAADKDVVLDDAWESASSEESESDDESGSESESEEDIFGDDSGNEVDLSNTLTHLKSQLKMLPKERKKLISETIIENEFSLPTNGNKLSINDMISAVDTSVSKDAILIDNEESSGSKALDTPLPVNIQQKHERRAAYEITKEEVSKWEDTVQQNRQAEVLKFPLNPTIKHNDTATTFRSTNDPTTDLEKKIHSVLTESALTDDKKEATFEELAVAKMSPEEMKERTNELRLMRELMFREETRARRIKKIKSKTFRKIKKKERLRDQDLVEGSDESDKEDHDRKRAEERMNLKHKTQSKWAKSLIKSGLSKDSSNREELEEMLRQGERLRTKQLGYEDGDQSDNNASDIERDYEEEETISNTSRAKLGKGVLAMDFMKAAEERHRQENLQEIEMLKKLENGEDLQQFSEDVNSINVIKNQGRRVYNPTAADGDINAVNKRARQEIEDDESSNLLNKLSKKAAIVINKPEETRAHETEPQEEANPWLIAGDTKRSSKVRVVDKDSSKQEKTLNKMKKKSVKSKIGENLEIDVGETLGFELDNSDDDERETFKQLDLIKDAFAGDNVVTEFQREKKRVVKDEDDKEEDVSLPGWGDWAGGKKQKKRKIVKKINGVVQKDNRRDKNMKNVIINEKMNKKNLKYQSADVPYPYESREQYERALRMPIGQEWTSRETHQRMTMPRVITKQGTVIDPLKAPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ95</accession>
    <name>G3AZ95_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_119151</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ95"/>
    <dbReference type="GeneID" id="18248683"/>
    <dbReference type="KEGG" id="cten:18248683"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_0_1"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="515" mass="56563" checksum="DB9BBC20D982639F" modified="2011-11-16" version="1">MDVGGFHEVPLDLRAITSEATSRQISRLQSRHSSVGDETSEPEVLHKTASEKDPKYARFSNKTKHVCLLISAMSGFLAPLSSLTILPAIPEIASRFNTTEEIINVSNAIYCVCMSLSPCIFSPCSDIYGRRYTFLFCSVMFCVSSALVAVSQNLAMFFVFRCMSGFFGTSFFSIGGHIVGDVYHPTQRGRAMAALVAGAQVGTGFGPVFGGIIVNFTSWRVILWVMMGAGAMVMVLAVFFLPETSVQTVHSLVLAEARKTNPSTRFVFVPFNPLRIMKALKYPNLSIDGFIAIATLYTMFQLQTPIRSVLEPRFHLDSPLYSGLFYLAPGMGYVTGSFIGGPWADWTVKRYMKKKGRRVPEDRLRTVLIPLGIMYPVSTMIYGWSIEYKKGGMAVPIIFLFMGGVAQTCIFPASNAYCVDSMPELGGDGIASSYFSRYVAAAVASASCLTSIKNIGLGWTCTITAIVLWIACGCAVVLIIWGEQMRIRALVKAGLRDADDLNSIQRQMVKRHKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZD0</accession>
    <name>G3AZD0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_133495</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZD0"/>
    <dbReference type="STRING" id="590646.G3AZD0"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015561_0_0_1"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="653" mass="73436" checksum="5366C33F2167C89C" modified="2011-11-16" version="1">MDVSRLEISTDTRKKRIINDQYRILRKIGQGQSGKVLLAERVIQSGDEDKLVAIKTINRIDKTKLITKTYLSHMTKIKREIQIMKECNHPNVVKLYSVIDDLKYDKILLVLEYCSDGEIDWKRYNHYTEKLKNGRGLTINKILRDVVNGLEYLHEYKGIIHRDLKPSNLLIQGNSMKITDFGVSLILENNANDAKELGKTMGTPAFFCTRALPVYIWSLGVILYCLIFNDLPFNGKNEFGLFKNIVTKDLKFPQTRFSSKFTESDRKEFNLLCDLISKILVKDPNHRYTIQNIKDHSFTTFDLTMSESLRFKRFNDGVIHNQLGLTNKIKKFFGGKPMESVNPIKIEHYDGDYNHLEPVDDLLDSYFDSSSMGSMESDDDGAEDIQPIAVVTGSHESIEDKKVEFLSNEDRKDYPLGPDRLFASNRLSERVQAPPSLNFTAPRRNTLSSPVKIGTSTPLAPVSTPLSASPSLSSSSSMISPRPVTLGPSSPSTSVFYSPTRSFFDKIHGMNHTISSLSSPPDTRGFKSKDVNDKLDLEPPNIFGSRHSSVGSVGSSHRKNSFGSPLMRITSSSSSLNLNAYLTDDNFSINLRSQDESDTDSVVSDAVGGSDDEVDDEADSTFVYGEVDTNINTNTNTSKFKFQDMGEYLDRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZX9</accession>
    <name>G3AZX9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113006</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZX9"/>
    <dbReference type="HOGENOM" id="CLU_2518561_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="85" mass="9212" checksum="DB91E1D05E48E63B" modified="2011-11-16" version="1" fragment="single">MASESESEMLASDSMDEFDEELYESSSLNASTQDVGRSTARNGTTKRPTYRRQVSSDVSIASVSTSAMSRHPSTTKKAASLRQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZY6</accession>
    <name>G3AZY6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113010</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="2"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZY6"/>
    <dbReference type="STRING" id="590646.G3AZY6"/>
    <dbReference type="GeneID" id="18246781"/>
    <dbReference type="KEGG" id="cten:18246781"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_1_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="270"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="399" mass="41597" checksum="8D25285BAB6CA95C" modified="2011-11-16" version="1">MSVYIVATARTPIGAFQGDLSSLTYSDLGAHAVKAALSKVDIKPEQVDEVLFGGVLQANVGQAPARQVALKAGLPESVVATTINKVCASGMKSIILGAQTIICGTNDIVVAGGAESMSNAPYYLPSARGGARFGDSSMVDGIQKDGLLDVYDDILMGKCAEKCASDHEFSREDQDNYAINSYKKAQAAVSAGKFRSEIAPITVKGFRGKPDVVVEHDQEPKNFNEAKLKSARTVFQKENGTVTAPNASKLNDGGAAVILVSESKLKELGLKPLAKISGWGEAATKPVDFTIAPSLAVPKALKHAKLSYEDVDFFEFNEAFSVVGLANAKICGLDLDKINVYGGAVALGHPLGCSGARIVVTLLNVLTQEGGKLGVAGICNGGGGASAIVIERLDHDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZZ9</accession>
    <name>G3AZZ9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_97209</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZZ9"/>
    <dbReference type="STRING" id="590646.G3AZZ9"/>
    <dbReference type="GeneID" id="18250667"/>
    <dbReference type="KEGG" id="cten:18250667"/>
    <dbReference type="eggNOG" id="ENOG502QR3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_7_0_1"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="73"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="445" mass="49891" checksum="2356019DA01ACDC6" modified="2011-11-16" version="1">MAFPCLDKLEKKTQQLCSNSLEDGPEPSYSKVQTGFHIYKSGKPIFLDHGGFLPEYEIAYEAWGTLSPQKDNIVLIHTGLSASSHAKSQPTNPKPGWWEQFIGPGKYLDTDKYFIICTNVLGGCYGSTGPSSIDPANGSHYATRFPILTVNDMVRGQRELIRDVFKASKIHASIGASMGGMQSLAYAMEFPDEVEKVVSISGCARSHPYSIALRHTQRQVLMSDPNWSRGFYYDKIPPHVGMKLAREIATITYRSGPEWEYRFGRNRADDSKSPAFCPDFLVETYLDHAGEKFCLEYDANSLLYVSKAMDLFDLSASNRERAVKNRGAAEAAYFSQQQQESTAVPEEPYEEKVTSATVTPEESYDDLKRGLAKISHKDVLVVGVESDILFPVWQQREIFDVLQANNPTGQVKYYELGTDISNYGHDTFLLSLDHFGPHVQEFMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B028</accession>
    <name>G3B028_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_103083</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B028"/>
    <dbReference type="GeneID" id="18245605"/>
    <dbReference type="KEGG" id="cten:18245605"/>
    <dbReference type="eggNOG" id="ENOG502RJSV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010834_2_0_1"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="373" mass="41170" checksum="7FD4D7BB73B3833D" modified="2011-11-16" version="1" fragment="single">KIVIIGVHSFLPTKFVKSMIGQTTGNSIRVVDAATKAVEAWVRSDTEPGFESMYHIETIALEGQGTVSERVERSAALLNNWADLIHECDFLYVVGHSHGAIVAIELLAYLLRSESPISISGSKVGLLSMAGPINGPISQLETKIVVRAYTQRENEVLSELVQLSKPESAESERLQQALNTLVTHNVKVTLAASTTDQLVPIDSALATTWYHPNIYRCVYIDDGPISIPPFVASLWNLVLVARNIGHLEHGIAKDLSERCVGRPPGGGHNRIVSQAGVHETALRFALETTNLSRQRDLMVIPSAYDGQTSLYKLPWTVRELVHDVLQTKHITAFKLVEELVSSFQTWEDVGKQWKDFKFALEAIDNADGEELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3B038</accession>
    <name>G3B038_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_103057</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B038"/>
    <dbReference type="STRING" id="590646.G3B038"/>
    <dbReference type="GeneID" id="18245602"/>
    <dbReference type="KEGG" id="cten:18245602"/>
    <dbReference type="eggNOG" id="ENOG502QR1M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004517_1_0_1"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="663" mass="75598" checksum="B41D79EC164E78E6" modified="2011-11-16" version="1" fragment="single">MGIKRENEHEDSPTESKIPRVSSPSLSLSRPISACQRCRKKKIKCDQNFPKCSKCDKANVECIGLDPATGREVPRSYVTHLEDRIAALEMKLKESGVDPQVVHDLAASTENTTSKSSISDKDQEEIQDQREQGVLMNQVKFNSINAKDNRSEATHHSISFAKLMSTAVKFKKRCSNVSSTPEIELDPTTSNVVSSEEILPALLPPKKTAQEFVRVFFAQSNSQCPVLHREEFLQTCFLPIYGRLDTNITLASNYTAINMSGLEDDPYYRDESLTWLAQYKQALNERMSYYKANNQKVDTSTLSNEISVPLKFHKPLFFLNIVFAIASSTHHLQYPTNISDSLRLAALKYIDQVYTSSDQLEVLQGLLLTALYSIMRPAVPGCWYLVGSALRLCVDLGLHSESINQTLKIDSFTLDKRRRLFWCTYSLDRQISFYLSRPDGIPDEYITTRFPSELDDALIVPHDVKVQDYSDKTSSSSSYKTISISMFRVRQIQSQVQRMLFGNSDLPRQFNTLSEWKQNISKQLKSWKSTCPKTRRKMNCDFNLDFFGLNYNHTLLILHGLSPKNFKLNKKDFSKVSECAKELINIYTQLLTNKCINYTWAAVLNLFMAGTSYLYSIYNSEVVRSQNSLFEVKKITQECITVLNTLIDRCDAASTCKNTFEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0A1</accession>
    <name>G3B0A1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92573</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0A1"/>
    <dbReference type="STRING" id="590646.G3B0A1"/>
    <dbReference type="GeneID" id="18250206"/>
    <dbReference type="KEGG" id="cten:18250206"/>
    <dbReference type="eggNOG" id="ENOG502RZIJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068936_0_0_1"/>
    <dbReference type="OrthoDB" id="4063051at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 C-terminal" evidence="1">
        <location>
            <begin position="174"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="257" mass="29368" checksum="5D8A80DDB39FE7E9" modified="2011-11-16" version="1">MSLPISIEDPHQQLDDFQLSCKHQLPIDAHDRFLNVCYVNYQKTPVFLLQSGMIDVYSTSDECQNYIKHRLLKHSLRDSSIGMLLKNTTNENVYVIVLIHELKVKALVVDLTIVARLNDYQDNNEDKFGDRTLTEVVDLKTRHNSIHVIDKVLEKKKRSKSSTPLPTSSVNNSEQINSMVSKVVLSGLRLRGMSSTAANSANEKIKIKEIYSMTYKSAIFAMRKFSNKPVHLNDIQDVVEKLLQIYIDVDTDNPFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0B5</accession>
    <name>G3B0B5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_119656</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0B5"/>
    <dbReference type="STRING" id="590646.G3B0B5"/>
    <dbReference type="GeneID" id="18248717"/>
    <dbReference type="KEGG" id="cten:18248717"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="440"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV65361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="750" mass="86265" checksum="145367B62A60EDB1" modified="2011-11-16" version="1">MYDWCINVTIGLLVCLTPFCIPIKLRNPRLRTVRTWLIVAFIISLFITFTPSIAVDGAPIHKYGEGKIAYYSCSSQVMKLAQFCPKDERYTCVCQNPNARASMAYCYDYAYSTVKYSMLDLCATECDTTLTRQDFDEALANYSKFSRDISHDGSLSDDQFVDFPVKLDHSQMLLYKRSYDQVLGNYDRSIYYGGVLILYWLVFFLGVSIINWSKFIFPHLVKRMVDPYTNWLRKHLFVPATAGLRKTNEKPFLKVLDFLVPTRLETASLTGFFILLAHLVTKEMHYVDGDPIFTSKGRAFLRYYAVRTSILTSSMMPLLILFGGRNNVLQVATRWDYSSFITLHRWISRMLVILITGHSLFYSLYTSDFYELASYDYIRWGILGTLSGLVLCVHSLLVLRRKYYEVFLLLHIVLALGFILGAYIHVMYLYCLWFYHFTFAVWIFDRVIRIGRLISFGFPHAHVMLLADEALKVVIPKPAEWETIPGGHVFLHFLRPSCFWQSHPFTYTISPNNPNEIVVFIKVKKGVTESLYHYLQTHPGKSVSIRVAVEGSYGEQTPASRYNSAMFVAGGNGIPGIFAEAVDLVRYPSNQKVRLIWVVREYRSLYWFYEELLSLKNTHIETIIYVTKPESYAHLDEFNLRFPGAEHEVSGEETSLTSMPLMSYGSSDSTTAEQVIDKIHRELSFITFEEGRPSMDGIVKHTIKESEGSAAFITCGHPVMVDDLRAAVVANIDNESHKRVDYFEQLQVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0G6</accession>
    <name>G3B0G6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113121</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0G6"/>
    <dbReference type="STRING" id="590646.G3B0G6"/>
    <dbReference type="eggNOG" id="ENOG502SDGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182424_0_1_1"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="65" mass="7396" checksum="EA6B34CA9E086F5E" modified="2011-11-16" version="1">MAVQTPKQRLANKKFSKKNTLKQTGQFKEDADKVEYPLPKAWIALLVFLVCGGALLEVLRLVFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0G8</accession>
    <name>G3B0G8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_119750</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685086.1">
        <property type="nucleotide sequence ID" value="XM_006685023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0G8"/>
    <dbReference type="STRING" id="590646.G3B0G8"/>
    <dbReference type="GeneID" id="18248726"/>
    <dbReference type="KEGG" id="cten:18248726"/>
    <dbReference type="eggNOG" id="ENOG502RZQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050573_1_1_1"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="292" mass="34002" checksum="4DDEE542A899FEC5" modified="2011-11-16" version="1">MLLKFKVVHYYLIPLVCLVVWWGMLTALMVCWVVQNKPQYSWNTEYQVPPYISDLGATNLQPLFISCAGFQAIFFVGTLTMEYFLRRYKKLQPFVSKKQPLFSIISIVCAIIGQLGILFVSIFKTTRFHRVHLSMVAVFIVFSFFTCVFNFLNSFIFGYYPTRLSPNHEKVIFGTHRWANLYMVSFVLKTFWLVGAVVFAVLFGWYMKDDHPSLSAAFEWTISYWYGFLLVLWAIDLFPSAVKHYQLRHPDQYPEKDLSHIHLDPNNPADLTKLEERSVSTFGSPTFAGQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0I2</accession>
    <name>G3B0I2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_97306</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0I2"/>
    <dbReference type="STRING" id="590646.G3B0I2"/>
    <dbReference type="GeneID" id="18250678"/>
    <dbReference type="KEGG" id="cten:18250678"/>
    <dbReference type="eggNOG" id="KOG1063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006430_0_0_1"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="201"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="807" mass="90246" checksum="F986DDDE1B429B13" modified="2011-11-16" version="1">MEQVPFAAEQDAVFVGANKQSFVVDYDYSHDLVAYGAGKTIALWKPTQNHHKGVFCTLKNHTAEVTCVRFVPNSPFLVSCAEDCKVSIWQRRDNSNHYELSQTMTEHTGSVTCITVLNEKIFATGGSDGHVILWGLDSSGSWDQITHFEVKSGFYPLTLSLLEVKQNQYILAIGGTTAHLYVYTFTFHNKVIDNLVQSAILTGHEDWIKCLAFTQESEDEFLLASGSQDRYIRLWRLRVNEKIDNSDEDSTKLILLSNKQYKFAVEHTKCAISFEALIMGHDDWVTGLSWHPSYDLSAPKYQESNKKLQLLSSSADTALMVWEMDHDSGIWICISRLGELSIKGASTATGASGGFWSCTWFVNNGAQYILTNGKTGSLRAYKNEDGDNNNWESELSITGPTKEVTDLVWSLNGQYFMATSLDQTTRLLAPWKLEDGSTWLEFARPQIHGYDMVCIDNISPTKFVSAGDEKILRVFEMTHSINRLLKQFCGIDIGTHEELPDTAALPVLGLSNKAANEQLEVGEASEQQDSEEAGDVKKDDILDDLTGPPLEDYLQRFTLFPEVEKLYGHGYEVSCCVTSPNGKLIASSCKSNSLKHGMLRMFNINNDFQQCEQTLPGHSLTITNIQFSPDGSYLLSVSRDRQFILWRVVDENTGQFEMVETNPKAHTRIIWDSSWLPKQLGSYFITVGRDKSLKFWYVDESSEKKVSLVDSLKASGVITSVSVHPEAIDNKAVVAIGLESGEIHLYYIEFGKSEKKLQTWAQIPQKIAPADKVSKLSFSKVLHDGKLLLASGSADTSIRLYSISIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B147</accession>
    <name>G3B147_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113638</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685682.1">
        <property type="nucleotide sequence ID" value="XM_006685619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B147"/>
    <dbReference type="STRING" id="590646.G3B147"/>
    <dbReference type="GeneID" id="18247058"/>
    <dbReference type="KEGG" id="cten:18247058"/>
    <dbReference type="eggNOG" id="ENOG502SF3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076668_0_0_1"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="4">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="235" mass="25410" checksum="79719B4E3DE16EBF" modified="2011-11-16" version="1">MFGFARNTSSALVPVSKQSSRYASRGKKVVSKFKKVDIQLLKDHPTLGQKGEVVSVKAGFMRQQLHPFKYASYTLNGLRIPVVEKKVAVVNTPPVVTSASIQKPSVGSFNKEDFSALFDTLKTSGKNKRTSKSEISFESINESSSSEGSFSASEIREYVPSVITLVTGKGVSLPVTKAALATHVFNVSGLEIPQSAIRIADSSKKPITSIEAAGEYSWVIDTPENLPVRISLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1A4</accession>
    <name>G3B1A4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_104063</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1A4"/>
    <dbReference type="STRING" id="590646.G3B1A4"/>
    <dbReference type="GeneID" id="18245678"/>
    <dbReference type="KEGG" id="cten:18245678"/>
    <dbReference type="eggNOG" id="KOG0216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="31"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="190"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="463"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="569"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="676"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1040"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV64922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1166" mass="131011" checksum="677119F0617F111D" modified="2011-11-16" version="1">MSTAKFRTLEREQRFQNPPKDKSAYPMLYEAIEPHIGSFNALTEGAHGGLLNLAVKDIGAKTIFDSTSTDRLGNKLMIKVDSVEIGKPSIPTNDKLSLNSNTLPYECRERMISYRSKLRLKVTWSVNDGEEMSEIRDCGLLPVMLRSSRCHLQNLSPDELVKHKEESDEFGGYFIVNGIEKLIRMLIVQRRNHPMALIRPSFASRGNSYTKYGIQIRCVRPDQTSQTNVLHYLSDGNVTFRFSWKKNEYLVPVQMILKALMETSDREIFDGIIGTDLSNSFLTDRLELLLRTYNKSYNLYSNQETLAYLGDKFRVVFDGTPDMSDIEVGKLVLKRIVLVHLDSNQDKFRMLLFMIRKLYSLVAGDCCPDNPDATQHQEVLLGGFLYGMIVKEKIEEYLNNFKLQVSSDLNRGLKVNFHERKYISRVFQRINENIGQKLQYFLSTGNLVSQSGLDLQQVSGYTVVAEKINFHRFISHFRMVHRGSFFAELKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHLAHKCKITTKQSDVSGVPGALSQLGISSVNSFAAGPGVCCVQLDGKILGWTSHEKAKIVADTLRYWKIEGSHNIPLDLEVGYVPPSNKGQYPGLYLFGGHARMVRPVKYLPLGKTDIVGPFEQVYMNIAVTPEEITNNIHSHVEFSPTNILSILANLTPFSDFNQSPRNMYQCQMGKQTMGTPGVGLVHRSDNKLYRLQSGQTPIVKANLYDDYGMDNFPNGTNAVVAVISYTGYDMDDAMIINKSADERGFGYGTVYKVEKVDLGMSRRRGDPITQHIGFGDDDWPEIWQNKLDADGLPQIGVKVEEGDPIIAYFDDTLGKTKVKTYHSSEPAYIEEVKLLADDTNSECQQLSIKYRITRQPLIGDKFSSRHGQKGVCSRKWPQTDMPFSETGIQPDVIINPHAFPSRMTIGMFVESLAGKAGALHGMAHDATPWKFSESDTPADYFGDQLLAAGYNYHGNEPMYSGVTGEELRADIYIGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRSGGIRVGEMERDALIGHGTAFLLQDRLLNCSDYTHTSLCKDCGSLLTTQASVPRIGSMSSIRCRSCSKKLESFSNEFINESDIWEDGQGKKFVGGENTTTVAIPFVLKYLDSELAAMGIKLKYNVQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1A5</accession>
    <name>G3B1A5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_103850</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1A5"/>
    <dbReference type="STRING" id="590646.G3B1A5"/>
    <dbReference type="GeneID" id="18245660"/>
    <dbReference type="KEGG" id="cten:18245660"/>
    <dbReference type="eggNOG" id="KOG2721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044271_1_0_1"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="17">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="18">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV64923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="244" mass="29086" checksum="C385DAE39746C74E" modified="2011-11-16" version="1">MANSKYEYVKKFERENYLLPDTYVVIRVDGKGFHKFSKFYNFDKPNDLKALEVMNTAAYNLMNQFGDIVMAYGDSDEYSFLLKRSSEVYQRREAKWVSLFASSFTAYYLMEFSKQFDLQSKMVPIFDARAVVYPNPQVVQDYFRWRQVDCHINNLYNTTFWKLVESGMTNQEAENRLIGTLSADKNELLFKMGINYNNEPEIFKKGTIFVREPREDKKRKQVVNKYHIDLIKDDFWHSREGLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1D2</accession>
    <name>G3B1D2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">STE3-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_104233</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1D2"/>
    <dbReference type="STRING" id="590646.G3B1D2"/>
    <dbReference type="eggNOG" id="ENOG502S44N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027592_4_0_1"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="46941" checksum="A0B7A7F5B5B5BD74" modified="2011-11-16" version="1">MDYIGRLLSGFSFITFAILIPPFIWHCKTKNIPAASLIFWLLYSNLDGFIGAIIWSGPDFYEGYDGRGYCDVVIKLEAGSSSGKICAAACISLHLFLVLRGSSPTFINRQSWKKICLDVGMCFATPVFVMAVTIIVQAQRIVITRYSGCTGYYEPTWVTLVVYLMWNIIWSFIAMVFATLTTITYFQKRHDTRDLLKCTNSGLNIKRFAKLLVFSILVIITLLPLSLYYFVHDAKSLQGEYNWDKTHYLYWNDTLYVEGDIASLYSKYIDMGMSVIVFLLFGLGTDALNMYKVGLLRVGVGKKLGIKDPRDPIFNSNTQTRTSTKQSNFTLGSDPYTGPTITDGINVEFNKIINSDIQVIEVEASNSSDLEKGPDISDYLDDHEVDSREEIAYIMNMADGDSHNIDFNYHFSEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1F3</accession>
    <name>G3B1F3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_121194</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1F3"/>
    <dbReference type="STRING" id="590646.G3B1F3"/>
    <dbReference type="GeneID" id="18248829"/>
    <dbReference type="KEGG" id="cten:18248829"/>
    <dbReference type="eggNOG" id="KOG0981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009193_1_0_1"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00660">
        <property type="entry name" value="Topoisomer_IB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="272"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="606"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="748" mass="86851" checksum="183EEF841A14CAE7" modified="2011-11-16" version="1">MSSSEDDIPIVQRSKRILDDSEDDVPISQLPSSVKKKVKRETDDSVSLNHPKSKSSNGTSKSSSNGNIKTPKKERTKKTPSDKKKPNKSLQVKSEDKPTKQEEDEEETEETYKWWEEQEDRDGEIKWDSLVHNGVLFPPEYEPLPSHVKLYYNGTPVNLPQEAEEVAGFFGALVETDHGKNPVFQSNFFKDFQQVLKECGGCNVEIEKFEHLDFSKMYAHFEQLKEDKKKMSKEEKREIKEDKERQEEPYRTCLLNGRKEKIGNFRIEPPGLFRGRGAHPKTGRLKRRVFPEDVTLNLSEGAPVPPPPEGHSWGDVKHDNTVTWLAMWKENIADSFKYVRFAQNSSVKGLSDFKKFETARNLKHHIESIRKDYTQSLKSELMQERQMATATYLIDIFALRAGGEKGDDEADTVGCCSLRYEHVTLRPPNTVIFDFLGKDSIRFYQEVEVDKQVFKNLKIFKKPPKQPGDDLFDRISPPLLNKKFQTYMKGLTAKVFRTYNASKTMQDQLDLIKNEGTVAEKVVRFNAANRTVAILCNHQRTVSKSHGNSVQKINDKLRELMWNKIRLKQMMLELDPKLKRKDPKYFAEIEDLSKEDIMVIQEKILERTKEQVAKKFERDNEKLKAESKDQLTANDLKERMQKVKELQAEFKIELASGKPEIKKSVTVEKLKSQVEQIEQRILNTQFQLKDKEDNSEVSLGTSKMNYIDPRLTVVFSKRFDVPIEKLFTKTLREKFTWAIESADKDWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2T4</accession>
    <name>G3B2T4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_120712</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685562.1">
        <property type="nucleotide sequence ID" value="XM_006685499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2T4"/>
    <dbReference type="STRING" id="590646.G3B2T4"/>
    <dbReference type="GeneID" id="18248797"/>
    <dbReference type="KEGG" id="cten:18248797"/>
    <dbReference type="eggNOG" id="KOG3719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_4_1_1"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF48">
        <property type="entry name" value="CARNITINE O-ACETYLTRANSFERASE YAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="797"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="839" mass="95119" checksum="6E6BF76AE40362B2" modified="2011-11-16" version="1">MSTYQNEQSLPSLPVPELSSTVHQLLIALQPLVSSEEYSQLLNESTEFLNNHLVNTIQTNFLAARHNPRHSCYLNCINDEFHPGIYGELRGDVLPRNPYLVLQEDPYSKFMNPPNQSQRAANLVNSSLKFIVSLRNETLPPDLTPRNKNPLTMNCYRNLFGSTRVPDMAESPHAYHQISIKTSRDPVHSNHIVVVSCNQFYYLPVLSEHQEIFFNDYDLSLIFQQILDESTRFDVVESINNAIGALTTQNYSHWKWGRAELMRSNASSLDLIDKALFVVVLDPNSPTTDQDKTMVISHGTSVLSSNNAQGGSCTSRWYDKLQLIVTKNSVAGVVWECTSSDSTAILRFISDIYTDSILKLAKNINAIEYSLFGDVRFVSNKLPKPSFQRLVFKKTPELSNLIHLSETRLADLINQHSYTSIKIKLNTELLNSYGVSTDSFLQVCIQIANYSLYGKVSNTLEPITTRKFKDSRTEMIAVQNDEIANLVKLFITNSSRAEKWSLFERCCKIHLKQYTDAMQGKGFERHLTSLLHVIKSPKASEFLNTLNAQAGVEKLPEFDVLRSQYVPLLSNPILNRILSPELLISNCGNPALYLFGIPPPTDQGFGIGYVIHKDKVLLTLCSKFRQNERFLSTLVKIINEVKAMVVSRSDFLVEINKDNDYRIHELQKLRVEQELKNLNFDSPSTKHPIEISVDSFTIPLDMSLKHQAAPDTDDELDYESSNSNNSAEFDYLGGYGYFDFGELDSRNIELNRSQSFLNSPSNLSSLSSRNPSQHNLSVLAKNLDLKEKHDLNERIREKLNKSADDLPRFKSPESPTVKDPQIEKGNPKHKIGRPLNISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B306</accession>
    <name>G3B306_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114087</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B306"/>
    <dbReference type="STRING" id="590646.G3B306"/>
    <dbReference type="GeneID" id="18247255"/>
    <dbReference type="KEGG" id="cten:18247255"/>
    <dbReference type="eggNOG" id="KOG2291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031381_1_0_1"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010753900" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="469" mass="54040" checksum="9A256DF742F0E854" modified="2011-11-16" version="1">MKWTSIVLIQAALWNLCMAVSALDIPASWVNEHYTRTIDLKKSYVRETVLVEAKNVDSSPISEYYFSLPDGFGGMGNVSVLSAILDEQVPLEFDKLENNVFKLKLPIPLATNSRVSLRIRYVYMDVFSPIPRQIGMGDIQTLLFKVNKFNYSPYPTDDLTVLVEGMNKAKEMDILDKPDSETAELDVPEIPTVSEDGSWRLGPVDNVKPWSLKPVGLLYDHNKPLAKVHLLERGIWLPSSDINEFQIEEYYEVYNDGAELNSGFSRVEWIKGNYETARNHWALSHFEFPSTSALEFDDYYFTDKVGMVTTHKKIKNFLLFEPRFPLFGGWKYNFTFGFNQKFDNHLKKLDDETYILKVPLLNSALDLTYSTVNLNFYLPENAEFVNVSSPIAFQSIETDFEKSYLDVSDGHKKVTVVYKNLFEDVSKVDVLVMYKYTKANYWWKVFKISGFVFIGLVSYYLLQLVDLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B320</accession>
    <name>G3B320_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_134639</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B320"/>
    <dbReference type="HOGENOM" id="CLU_1115630_0_0_1"/>
    <dbReference type="OrthoDB" id="4026811at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="249" mass="27038" checksum="4AFDC5AEF3B411E2" modified="2011-11-16" version="1">MSFFLLPPVSYQTQQKLKKHSASGSSASRRRHRQPSSASSASSVKSAPRSSRTVSTSTASGRSPPAITNPHAYTLDNPSIDEISNLDALSITSDKSPKSKSQPNYNCGAEINELLGTSKHRGRGHRRRSQGGSVKTSASAMDASSTYSHRQYQPSAYSTSVFSEDDSLVQPVANGITSNYRMEFRDKVHPVEDADANDIENSKTSVEFQLSEDEAEGGEGNQLTRVYSDVDSIFSTKVDVSPKKKGLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B357</accession>
    <name>G3B357_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_98076</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B357"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_6_4_1"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442819" evidence="1">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="43"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="176" mass="19847" checksum="B3B9BE46902A36B5" modified="2011-11-16" version="1">MHISVWVLWIGLCLRLKAVLVTEIEIITVTQISYTGPYEFNATFAHIMLNHHNHKRKLHHAQQVSWNNTLYDYAAGFANQYDCSGELTHSGGPYGENLAAGYSPSGAIDAWYREGDSYDYAQHDVYNHFTALVWNDTSQMACATTYCGTVWGSYIVCSYYPPGNFVGQSEQNVFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3F9</accession>
    <name>G3B3F9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_105290</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
            <topology evidence="1 7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3F9"/>
    <dbReference type="STRING" id="590646.G3B3F9"/>
    <dbReference type="GeneID" id="18245795"/>
    <dbReference type="KEGG" id="cten:18245795"/>
    <dbReference type="eggNOG" id="KOG4527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169812_0_1_1"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="82" mass="9487" checksum="8BFA4BB9504931D2" modified="2011-11-16" version="1">MNRLLSQKLAINNRMMVRNFQSSSKRLSSVFGHPKEGVYSNIPFTIKRKIIPLSVYYWGTLGFFFSFPFLTTLLHLKKSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4J9</accession>
    <name>G3B4J9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113999</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686617.1">
        <property type="nucleotide sequence ID" value="XM_006686554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4J9"/>
    <dbReference type="STRING" id="590646.G3B4J9"/>
    <dbReference type="GeneID" id="18247208"/>
    <dbReference type="KEGG" id="cten:18247208"/>
    <dbReference type="eggNOG" id="ENOG502S20M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2350783at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA C-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="189" mass="20166" checksum="D600DE6C708F0FD2" modified="2011-11-16" version="1">MEFPPGEIRDIIDEIAHILRTKNYTLAVSEAACGGLISAYLISVPGASDFYIGGKLVYSLKQRLRLSGWSADEIRHYMGPSEVVALRLARTTKYELGSTFVLSETGFAGPTVDLHLTDGGGTGTSAAGANASGTTVGASAGPGDVYLGFVGPDRELSCKRQTHSANRSQNMTEFARFGLEFLLDQLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4U4</accession>
    <name>G3B4U4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_134448</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4U4"/>
    <dbReference type="STRING" id="590646.G3B4U4"/>
    <dbReference type="GeneID" id="18249794"/>
    <dbReference type="KEGG" id="cten:18249794"/>
    <dbReference type="eggNOG" id="ENOG502QW5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_583927_0_0_1"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="468" mass="53676" checksum="6793F465EE84C4D6" modified="2011-11-16" version="1">MLQTLMYSPKYDLNSRSLQSINSVSKQLNIHAFELKLLHTFRTSVGPFVAHMDGPIKSFIMNDTVALFLESEVVRNSIFSLACVNSWQFCKEKSVIPMVSLVKRGKVEIGTRSSLFGFHSSIKDVSIPTLFDKDFDFLEGINQSLYALTSKYFANLVTGCNDIMINRVDRSSGTVVVDPKDALILQIGVMVIFTFIGSHGHGLVPLVNFDENDEYVYHYDQIINMNTDFLTISHNLAAMAEVSLYSSTGATLRKPIHTRNPTMVYPIIVKLTHELNVTDIPGTSKLNIRRSIGILDGCLTISDKNNYPLPSFKFLVLIREPFRNLVRDKEFFALRVLYAFAFVCEISQFGLFKDKSIWRDYMAWFKNYNMKMGRWQYNLDYILWFIIEHDIKLYALTTTQFVYTDPEIIFNDYILANPEFDLDDSFPFSSSVGRSTDFEESGSLIGFEEYNAFTNPKDNNYDMNLMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4W7</accession>
    <name>G3B4W7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114034</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4W7"/>
    <dbReference type="HOGENOM" id="CLU_3068482_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="53" mass="5980" checksum="90C5F856D669CCB7" modified="2011-11-16" version="1">MEKKQVMGAHGKTVHGDTIRNKNTDSHESVMITSIFSFSTEKQFSAKLRTIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Y2</accession>
    <name>G3B4Y2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114050</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Y2"/>
    <dbReference type="STRING" id="590646.G3B4Y2"/>
    <dbReference type="GeneID" id="18247231"/>
    <dbReference type="KEGG" id="cten:18247231"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_683543_0_0_1"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="400" mass="45956" checksum="7EBBB4269DB58BD9" modified="2011-11-16" version="1">MVSSSYSSNNSYNKYSFRPSHSIPTTNLNVDNNVIPNFQHTSGSTNQNLQQHQHQQQRPSPLHQHSFTTSDNSLTNIVPTPPQAINYVTEPDHYMTYGEFFSNLSLADGNDEEHINIVDYPVNDLILMLSCLLTKIIEANDKLHPNHFDSTIAIRQKLKEEKRQKKLQRKQHHQHQEDLQQKQQDPNRINVNESIIEDDSSDGDEEDEMKNRYLANVLAFHGTNVPGISLHAYLSRVLKYCPVTNEVFLSLLVYFDRIAKKANNLKKEGDPDGEQLFVMDSYNIHRLIISGITVSSKFFSDIFYKNLRYAKVGGLPLEELNYLELQFLLLLDFKLMISVEDLQNYGDLLLRFWKREQITNELVHNTSIDTIPPSTDSGSQLPSQQSNSSEVQPQPQQTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B570</accession>
    <name>G3B570_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_130674</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B570"/>
    <dbReference type="STRING" id="590646.G3B570"/>
    <dbReference type="GeneID" id="18249468"/>
    <dbReference type="KEGG" id="cten:18249468"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007090_2_0_1"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000221">
        <property type="term" value="P:negative regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="80"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="257"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="257"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="641" mass="71123" checksum="48235B4782F8462A" modified="2011-11-16" version="1">MSHASTPGSKRSIHEIESDVPSFEDPADLVNAVISCLQTPDEKTNVSINYSNEKNIATEVQAYAKISGSTWTYYVKSLAISIGRNTDNQGSHTNSIDIDLGPAKVVSRQHANITYNLDLRCWELKILGRNGAKVDGVKVGVDSSPTPLHSGAILDIGGTQVMFILPDSPPKLDQKMMELCLSRYQSTMSKQRKASTSTNTTSYTYFPQQHTMVPQTNKTFQMFEKNHLTHSPSQLSASSLQSNLDQDLSKEESKDIKPPYSYATMITQSILSNEDGVMSLSEIYDWISGRYAYYKYSKTGWQNSIRHNLSLNKAFEKVPRRPNEPGKGMKWQISESYKDEFLNKVSNGAISKTRRGSSVSRQLQLHLATHQALPESGRYYMKDDKQGSNGVSTDGHSRNNSIGVNNLQYYPQHQQIPPQGLSQQIPQNSTQSHQQVPLQGGIQPQQSLNSQMNGNGYMQRMNYQPLMYNLPNDSPIRLNDSNTPKLPKTNGNLYNLPPPPSSSNIGLGTSAPANHSRSNSYNQPLNDSFPTSEPNSSNQHTNATSDLALGFTSPKKVAPLEAFTPERGSKSFNHKNLSLPNGMNTNQSSPAFWNFVQFSTPNGQTPLRKTGDESNEVSPTINRKFNDKDLSPIKNKEAEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5H0</accession>
    <name>G3B5H0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription regulator Rua1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_135055</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687016.1">
        <property type="nucleotide sequence ID" value="XM_006686953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5H0"/>
    <dbReference type="GeneID" id="18249839"/>
    <dbReference type="KEGG" id="cten:18249839"/>
    <dbReference type="eggNOG" id="ENOG502SZ9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491750_0_0_1"/>
    <dbReference type="OrthoDB" id="4096316at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="Rua1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator Rua1 C-terminal" evidence="2">
        <location>
            <begin position="408"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="554" mass="62087" checksum="678F822CA6CFFB7A" modified="2011-11-16" version="1">MDYSLTFAFTDRNEDSYAPGQFITDPITDFTTSEFDSDEFLAMMEEITDLEFQHSEVPNTVLNSFSSVESEAMELDNELSLSLLVPHLVNQEGENVATFGQTLRQVFNNQSVTANSYGHVSEIYANGHLVEQDVQVGSSQQNAQFATNSFNQSEPESSFDSEEEPSVLFGGSNSSNNTLPSLDPELVTAYELYEPSGFEKISMRLASDADLFANIDEAIKDFMSLKQSEESSEQRVIPQTLQVSTNLQVPHNSPVVEASTTSTNVIPSITREQPSLRRNSKASLSNRARIPSVFDFTKQEVVEQILSHVDDRMNYYKKKSGASKPGSYKGDYAKIEDSRFTPVTNLYETKIALPHNTCHVLGHPKHLGIDGGKATVTRTRYIRGTSFNGFFDHPDLELKRYEGSGDLIYEPEYYRVQMINVCRNDGSSHRVPINQTRSGLCPYCEDIKFYELRNSSYGQHLAFHHGIGTDSFLTPNPFETKVEPKTCGKVVACPVCFQAISVEKSSTTASVQPLYTYLRHFKDFHRKGVNHKVNNKVYSTVPSFKGMYLDGISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5H9</accession>
    <name>G3B5H9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein CSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_123190</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000126_1_0_1"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="4">
        <location>
            <begin position="35"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="5">
        <location>
            <begin position="1887"/>
            <end position="2851"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="5">
        <location>
            <begin position="2883"/>
            <end position="2975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2000"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2975" mass="339237" checksum="BE9663D9D20D2041" modified="2011-11-16" version="1">MAVQSQFIQVASHSTDSASSWIYLVDWILVLILGIAFVFYFGRFLGFILSTMMRFALWRTSGIMINIESIRFSPLGGRLMIKNLTIGTENQTVSVLRVNLTCRYWLWGSTRLAEYVVQEKDETSSTGSDDLKSENDRLSTRFLLSLEGLEIFMYNRTFAYDNIMKILTKDDPNMDSTPEKLDDHEKDISDLRQRSNRSNNSVRDSTSKSDESTIHHSEVDMDKLNHHLSRLLSVFPISVSIKRAVLVLGNHSTPSLLIHSCKSANGIADIRRTDSKLDICKHLYFFKMEKFQILMKANILYDESSQGNQPNKQNGNTHAASVSKFKKLQRTLNVVPSIFASFSHEKASPQVDYQNWIGLRRYLNASLDDFNYLYDNLMNSNEEYGKYSLILDSVSTQFSYYYDIPGKVDAKELNTFPEFGADIRFSMATIHYGPWADKQRVPIQQAFFPPISRDTIPSPKPQPGQLRQYQGFKVNVVAEDEIIFRIPTREPSKDKEALKTARTANNINKPIRPFGWLELKMGANSSISSFSSFLCSEEEGFPNTLFAVFLQPELSTSVNHDILYLADVHTLDAKFSFPLEWNGPCEWVFDNSSSNARIFFLREHTLLISDMFADFGSGAPAPYENFRPFTYLFNWNLQNYRLYLNINDSNIINNPLDFDSNKYLSVQGKELELALEIPLLTQVTRLTSISFKVFAPYFDLNLDVPPWHTMNSFNKPSVLIGRANNFTIDGSYSYLSTVEINTHNTIVIRSKGDDVMVKFYGILMKYIFIIRENYLGDSFHFKTFEEYNNDHSMDSDIHTTSNTTLTEQFDYWKMVKTDNNVDVLFSFQVRNGLLVLPHEMYGTESHIALSFDYFDADIRFTNFYMDMQADFSPTYGMFVKLSKDVNSDDNLTDIKGYLQRFKVRENFDILIDEFSVHGHRMFGIPPKEVTYYCNWVVATNLISIDSDPSFLLYLVETLSTFMASFKDLENALHPTLPTIYDALCFSFQCPELNVKLSCGKEAVVLNLRPVVFTFNDIANSRYSAKLSVNIQEIEHKIVNEETKNISALFRTSLVIDNILRKPKYNEHRRLQQEHIRFNDAPFHRASQMLFEETKNANYYEAYRSIINPVSLPDVPLPLNRYTNDINNPTESLGSYSSSNSSLSEQELRGDRLFISPTLDYAEEDFQPDSQKDESFKYENLIYTFDDIIGFISPKAIEVYASFQDSMHNPDLNNLMDLFEKHVVDDLKLLMLQVSTNENQRLVAPSINISFGEFHGMNEVEISDALKYSSAINILVTEPSMALSMTEERRKLHSEEYLSTKQTSTAFSFKNIIVNITSPKDFDDSISLCVKDIEFWQADDKKEEISSLIVEDVSLDLGDAQLIWLIRYIDFLSRELQPSLDAFQKNSEIQGKSQAALVYTLGLASKKYKVDDDSTVLTKPAYVLRSLKEHIRVFDSWKVLVRLRHIFQSMDDQWVTDQENALRQNGWKIPSTAYEETWDVFSKWRSWESNFQERETFFQKIFNFLPVIQKSGIFQTTFHRIAIEFSNQYSKVPDYIEVQNAYLSFTTQKKDAIVRAFHILANIGSYKGAISPATLTVIPSLMEEAERFKPKRKASEQDVQTESAISVVFNINNFDQQLQLDYLCFQFQAFNLSATATCQAIEEDSSFMSFTAQASSILFQMKHDSQQLISHGLEEISVVSYGGNASTEMVVVDAFVENSYSKIIDDKLSHTIEMAIEMDMKYLELLKPRIDPTVTSKDDHEFDFHELLNKKDVIVNVQVNHFSYMISLLKTISLHGAVYDNSISLILSDGAADISSLLQKIDFNLKTPSYSILELEHSQMLNNIKICEQNGTPAVSVDSQLGFSKIFCPKLIRSINEILDNFQDSVLEYESVTPLRTSESKFNLGEIPIDVKFATDYVGMSFLADRSRYSMESENIEIKLSNIITPEVGISRTVSYYGSVSVPSFRISIADRIIPVGLSNIIDVNILIKLINEKKHNNRQILEVVSHYCRVCLSFGAIQRIVFLADELAIIKKELEKQLKQSRNKKTAINETKESFLSFISGFHILSYNFCIGWIFEDARNDYPGLILGAERFYAVTDEGIGKLSLMEAYLAVAHGSTSSGFFSTQSEKTNSNRAFLPFVQFVYVVTDELEGKRMKSNITGDELDVNYLSNSFHIFEYVIKSGSQVQAFFDKRVKIMDKWKDDSKSHEEQQVDYMNSLRSTFSSIECKATFAGSIVSLQKIGESGDGSSFILNFPAVKSTTTYSHYKSGAKKHSIKSELFTSSSDNKIYASCVPVIMDIVYGVKRMVRLSNQNHASTSEKEVPNKRVETSAGQKNFSFSTILEETDIHFGIKVDKQKISLSCEPTAKVEAIVGIGGIYFQVNSGSNASINAIAVLDKISAAVQHVYSREVSGSIDVNSVVLTTSVELLNEISVKSASCISNVEGYVNVKQFQDLALFKDIWWPKHLMREYEEPQVEHFLPNSNELADNKNIAWRFKEVSTTNAIPWFITFVLSDVLVKVNCGPSLGEMMFKLNEIWAVSQKTPDWTQQFKMGINAFEITSEGRLGGDLIANDLYLHSEVTWKLDEGKVLDVPLILVSAGVDQLAVKSTFDYHVFVVISISDYSIDLYNQKSELMISKDHLFVAAQFKACEIYMSSFTASNVLDIYNAVLRMTQDNKISYKETLHDSNKNKSHSAKKSNKPYNNAILETVKKLETEFEVLAGTLLIHVYPTSFDDSKVLVIKLDESSAQFSQNEYNHGIANQLKIQFNDLKVSLSTNTAVSEDFIQEATVEDFSKYARKARGGSIFSFPSFQISMKTFQKYNTNLIEYFYQSTFGGTVDIRWNLGSVNFIREMYSIHINSLASRNQFRKTLQQNTGTEEVNFKKDIFTDKDDNRKTLALGLLMDPKASETSTERIDQALNEKIDKVSKSSKYLYLPLAPPIIEAPQLKELGNATPPLEWFGLHRNKLPNVTHEMGIVSLQKVIHQVESEYSRLLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5K7</accession>
    <name>G3B5K7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114550</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5K7"/>
    <dbReference type="STRING" id="590646.G3B5K7"/>
    <dbReference type="GeneID" id="18247473"/>
    <dbReference type="KEGG" id="cten:18247473"/>
    <dbReference type="eggNOG" id="ENOG502QPSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_1"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="50"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="367" mass="39652" checksum="132D122865CDDA15" modified="2011-11-16" version="1">MSNTPIPEEYDDTRILGYDPLVSPLVLTNEIRATSKALDVVIKGRYESGQILKGKDDRCLVIVGPCSIHDPDAALEYAARLKKLSLELEDDLLIVMRAYLEKPRTTVGWKGLINDPNVDNTFDINKGLRISRQLYADLTGKSELPIGSEMLDTISPQYFGDLLSFGAIGARTTESQLHRELASGLSFPIGFKNGTDGNIGVALDAAQAASKGHHFMGVTKNGMAAITTTKGNDNCFVILRGGKKLTNYDAEAVKAAKEAIAKSAAPSTKLMIDCSHDNSQKNYQNQPTVLSSVADQISNGEDAIIGVMIESNINEGKQPMPPAGQDRSSLKYGVSITDGCVGWETTVSMLKELSKAVQTRRASKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5M8</accession>
    <name>G3B5M8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_130760</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5M8"/>
    <dbReference type="STRING" id="590646.G3B5M8"/>
    <dbReference type="GeneID" id="18249476"/>
    <dbReference type="KEGG" id="cten:18249476"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018539_4_0_1"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="10">
        <location>
            <begin position="237"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="566" mass="64929" checksum="8F5B919958ABB89C" modified="2011-11-16" version="1">MSANDILDVLNIQRDNSGQPSKKKAKHGNDSTNLQARQTGMARELYNLLGPNTPPVNLTNANNNVGVKDRWKSKATPWTLKDFKPKSGDPLTLYHWVRGSKELLEQDNIQVQQPYFFTKFSTNVDIPDFVDEETFNKYMEDIEVEERKNSELWEERRMEKERQRQEKLAKEKAARDNEKKIKGEKGEVTGISESKKDASSEVTSQEDGSQSEISKESTQAQSEEASVIPESKTNAIPWTYKETKHLFELCNSFELKWHIILDRYEYSSHRSLEDLKEQFYRVCKRIYSDDANGNPALIDSLGSFSKSKEVERKQYLERLLKRTPAEIAEEESLVIEARRFELAAKKMLVERSNLLTLLDSPQTSQSVQQYQSSQGLTNLYNNLMIMDKNQKRRQLQNQSSPSHDPIPPPIPLAASSSIRKERTFQTHLQQHLSNLVKQNQSQGNKNEISAIHKLLMKRLTAKEEEAYGLHYHANERLTPGVILRSSQRLPGLQQRQSVLKSVTSVFTELDIPTAGGTSWRPVMPTRKAMAKYDELLRAVVALLEVKKGRDKLEAEIQLIRSQKGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5R1</accession>
    <name>G3B5R1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_98431</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5R1"/>
    <dbReference type="STRING" id="590646.G3B5R1"/>
    <dbReference type="GeneID" id="18250771"/>
    <dbReference type="KEGG" id="cten:18250771"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="360" mass="40159" checksum="B3397A07C0CA993C" modified="2011-11-16" version="1">MCKAGYAGDDAPTAVFPSIVGRPRHQGIMVGLGQKDCYVGDEAQSKRGVLTLRYPIEHGIVNNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPKNPKSNREKMTQIMFETFNVPAFYVSIQAILSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHGILRVDLAGRDLTEHLMSILSERGYSFSTTAEREIVRDIKERLCYVALDFEQEMQISSQSSAIEKSYELPDGRVITVGNERFRAAEALFRPSDLGLEAAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILSSLSTFQQMWISKQEYDESGPSIVHLKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5U0</accession>
    <name>G3B5U0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114600</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687419.1">
        <property type="nucleotide sequence ID" value="XM_006687356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5U0"/>
    <dbReference type="STRING" id="590646.G3B5U0"/>
    <dbReference type="GeneID" id="18247498"/>
    <dbReference type="KEGG" id="cten:18247498"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025224_2_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="441" mass="49156" checksum="E9E3BF6FBBFC93CE" modified="2011-11-16" version="1">MSSRTDTPKEIELDLFLFTHNCGKRGIDSDVFIPKVAKILPKEVAGLYVFGIEEACSIMDASSYTTSNPHFIAVNQVLLDTLHKAYGMSDTKFHTVGICHIGAIGIFVITPFPSKITKVRSASMGCGYFYSSMKGAAGLRVTWKPSETSGEMVDLTFADAHLSAYEGEYYCAKRNYEVIRLMRALDFGDGYSFLKPNSHSFFMGDLNYRTTKDIRADTSAIEELTSLQDQTMTTNSSTEELVQKYDELSESIRNDQVFMGFTEACIDFPPTYKFNLGTAIYNTKRSPSWCDRILYQSTYRNRHGAFKSGLSSSAVPRVKEYNSVKALFTSDHQPVYLSISIPFEPPESIISSSGYLKILPNDQGIDHFHRKNSNEVIADSASGPTQIYGKSTKLDRIIRFYLTPLSDSVIGNGLWVSTTPSGRIAILVGLLLLVAVYQIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5W9</accession>
    <name>G3B5W9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">40 kDa putative membrane-spanning ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114619</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5W9"/>
    <dbReference type="STRING" id="590646.G3B5W9"/>
    <dbReference type="GeneID" id="18247510"/>
    <dbReference type="KEGG" id="cten:18247510"/>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_14_1"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="132"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="362" mass="40448" checksum="DF6EC0946ACA3B82" modified="2011-11-16" version="1">MNRFKIDLGKVKIDLKLLGDLFFLTGAGLSMYYLITHILNDPLNDTIKSKESKKKSQGILKKLQDSNPDLKNIVFTEYEKSLLNSLIVPDDLKVTFDDIGGLNDIIDELREAVILPLTVPDLFQAHSSLIQSPKGVLFHGPPGCGKTMLAKAIAKESGAFFLSIRMSTIMDKWYGESNKIVDAIFSLANKLQPCIIFIDEIDSFLRDRSSTDHEVSAMLKAEFMTLWDGLLSNGRILVMGATNRQNDIDSAFMRRMPKQFAIGRPNAAQRRSILTKILKDSQVDSMDFDLESLVLNTKGYSGSDLKELCREAALNSMREFIRSNYKNGKKVSVENGSAKVKPLRTNDFLKNIPNAIPSSSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B605</accession>
    <name>G3B605_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mis12-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_94113</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687436.1">
        <property type="nucleotide sequence ID" value="XM_006687373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B605"/>
    <dbReference type="GeneID" id="18250361"/>
    <dbReference type="KEGG" id="cten:18250361"/>
    <dbReference type="eggNOG" id="ENOG502S72R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046437_0_0_1"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37832" checksum="41001F8044584BA3" modified="2011-11-16" version="1">MTTRVNSSVNNSETGTPSTTTIEYDHRVTSVLTEHFGYPPLAVIDDVINAVNHILYKCTQAMETYLVEQHTKRIEEFKQIKAENASSDKDEQALLKEHEDLDVWVNLPKDEISLGTAKLETLLENQVDKNFDKFELYALRNIFTIPVDLVDNGWIRLKHHEHLDFSKDANREDDEVINKLIKDIRLELKLREILKLQVEKGKRLVDMLRKYSNNLKYLNETEINKNLSEKGKKILEDLSPIDDNLYFILQQVNVLIEQMNRLYVKFEKNKVNMNFKPSLRDFYINGKSFKLLQSIGVTIEDSSVDLLGDTEELKNGVESVVLDDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6B3</accession>
    <name>G3B6B3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_106212</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6B3"/>
    <dbReference type="STRING" id="590646.G3B6B3"/>
    <dbReference type="GeneID" id="18245869"/>
    <dbReference type="KEGG" id="cten:18245869"/>
    <dbReference type="eggNOG" id="KOG3480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162151_1_0_1"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="14">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="90" mass="9910" checksum="4924B68BA0534A04" modified="2011-11-16" version="1">MFGLGGAPQVTSDQKLQAAEAELDMVTGMFNSLVEQCHAKCINKSYGESDISKQEALCLDRCVAKYFETNVQVGEHMQKMGQSGQFMGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6F3</accession>
    <name>G3B6F3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_123748</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B6F3"/>
    <dbReference type="GeneID" id="18248976"/>
    <dbReference type="KEGG" id="cten:18248976"/>
    <dbReference type="eggNOG" id="KOG1822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_231988_0_0_1"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="2">
        <location>
            <begin position="2011"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="2166" mass="245365" checksum="B2452C5FD55F3137" modified="2011-11-16" version="1">MDESTLAHVLKDFDKKELYHELVNLNLTLTSAVSASIDADFHNNDVDYNLCLRQLNDIIEKFNVPPPSKSKKSKQDDTSHAETSKVQPSANLFKVIARNLVLVFHQLPTKIYDVANNFLNHLTLNTDNSLSPMAQLGIIVMIDLYEAFPNSLGSLISFSVNQIYKILKKDPTVSSNLVYLLNSLTKYSTRNDIDDKLQAKLLKIINKNITLLPIKFDIGESTSADKDVTSISLKKNYILVLRNLCILSVNANYEHLLSVSASSTSGAKMKPESIMSHQHQFQSNLLTSIEKPIFYGLSDYCKDVRIAAVESLAHLFINFIPTGKFNPVDYLISLYKLPDLNCWSEDLTKLKVEDQYILPKKEYSHADFDDLLNLNADQLCFNIGIVETLIFYIQLEQFQNSDYLPSNLESIIGLILNKFSPLSTSSNHIQSSSWVKTLYQWQKVIEFLIKESGPNCHEILVSYLMAKFDTNERSDVEESSLASKDKKPSTLFSLKGGRTSSKSKTSEDIQLYHNYFQCALALSAIEQVLPFGIDFNSFINSETHKQEHIKISEENEEENDDSRRLEFPQKSLLVELLLVLIINKSDYIRIYALNTLLKYTKINEVEVNQLVLSCFRSYSTEWESYHESKQAKVQANSETNTSSLEAVKSVSYALTLSSLLSQTESIHLQNSTIVKILSFCTQTLKQSNSYSRSNNLKNLTCWTILSSLVTLYNESEFVKLNSSQFLVFWKSLLTAQYVVTNLSGEESVQEREILDNLKLRNISLICLSNYIDTVDMTPESSKQIQFLLTKAYNYLGYLESNVEEVGNVTSFNGKDFNKEDFYINGTGNPLFSDVGYNNQLRSREGMVSLIFYGKKIILKNFSKLAIHLKNDINSSMIVLLLKTFSDPTTFSIDANKDKKQAKTKGAANGINDFDPSVILLNDDFNNNYGVTSKFSDFSTEIDELLASHKEAVQTGDNGIFYSDPFESTVIHKGIIENGVNKEVKFVCHPWVDCFEQLIFESAVHSITYDPVTVICGGYSSKYKTSTNITTSIVDLSIELFQLVFPYLAVKVQQSLLEQIRSSLASKSVHPLRYKAMCVNISIALHGALSFSSSKDILLDKEIIGVTIDILKKMETSSPNMIEINSESIGIAASFAQKKVISEQIDSYVSLIVNDSNPLVRGKSILTMSKIYSYTGIGANDIYNVVSQLLNDPNPVVYYYSLLATTLLFDSKFANNAWISPLISNLFEGYLEDSFGYDVKKKEYMNLKYKFGSVGLVAQLLKIFTTTLGPNLRSLPENNRNELRSLIVSLRYTIGASSIADNINIFDQLLRLLQELIIFDPKLIPNELQFYSSTLISVVSKNLKLGLSSIPPTSLNLDSIFPFNSSFELFKLGYACFTELIKVYGQEVLTKEVVQLIWVSLNIKPAEESKNLISIWMDSSIDMNWFATLNSLLKISSKKLSQPFIEANYQQKLLPLLQRQKKKTDKTIDFKDEEIENIVGDDGEVDDKNEPITWEFKLFIYDLLNNLANLASRNSSLSDRLKPRISDLVKIAFVGSTSPINAIKLRGISLLDKVLALFGDTEDSMYTGISILEQQQAQIISAIMPCFSSGCSAEVIANAVNVSSKFINLPRIKFYSKQRIMKTLIFFLEELSSNKFIRFGFLENMSEYGKKSIQVSILNCWALVRLNAYEDLKNSGLSKAMITNESVDFDDEDPEPENELIETLTRYSTLLIALWIVSLKEYSSLKYSDANPRELEIYNNYWINFVSVLSLELEENTEFVQEHLGGDASTFFFILFSQCVESLIKNRNTVEILVSLSSLVKNHELVDILFHDEIFGEVVDLFDRLILVDDQAEVQIKLINIVSRLFQTYFDSHQEIIEGFDKLFELIRLCMLPLFNNLPFLRADYNSEDKQTLMVLESVDSGPNLVILKNVMTQLVDMLPRFPDVVRIDLHSCLLFIIAKIYEFKNELLISTVLPYLKQIVGESKQSNPKLVNDFDTIIQQFYPIRTSNSSVLTYMVLMTSGDIQLNEADSIFMKDSLVTMLSNSETSSMGLQCIRSLIQHSHSPLIVKLLVKELIQQLMDNTGNPKLALEVLIYFVKSQTDPAVITKLYSVLIQLILRLKSTVNQYYLHEKLIGLITFNSDSFKIIVNEGLDADQKKLTELLVKLNVGSEEEELNQDSEIQLKTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6M0</accession>
    <name>G3B6M0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease H</fullName>
            <shortName evidence="4">RNase H</shortName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114804</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687494.1">
        <property type="nucleotide sequence ID" value="XM_006687431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6M0"/>
    <dbReference type="STRING" id="590646.G3B6M0"/>
    <dbReference type="GeneID" id="18247589"/>
    <dbReference type="KEGG" id="cten:18247589"/>
    <dbReference type="eggNOG" id="KOG3752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017067">
        <property type="entry name" value="RNase_H1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF25">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036852">
        <property type="entry name" value="Ribonuclease_H1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="5">
        <location>
            <begin position="122"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="293" mass="33139" checksum="6FC8BEC8D354F010" modified="2011-11-16" version="1">MPYYAVASGFETGVFRHWTQVKPLVDGYSKPVFKKFNDEESAKQFIRNNSMSSRVVQTRRYGTLGRVESGTVSSSVSTTKKNSTCTPLQVEMKLNSLNMSYNFEDWRTVEQEIKWENHLISSDQKIEIYCDGAAKNNGKSNALAGYGVYIKDLSPKGISVAYDQISIDKLKPTNQFMELYAIRHALMIIFSSLEHCKRYEGKTSIKILTDSQFSINCLTVWYKNWESNGWVNTAGRPVIHQQCVRDCLKLIDSIKDSVILSIEYVPGHSGFLGNEVADRLANIACDSMSSRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B759</accession>
    <name>G3B759_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_130637</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B759"/>
    <dbReference type="STRING" id="590646.G3B759"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014602_0_0_1"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="101"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="657" mass="72546" checksum="FCB8215D780111A2" modified="2011-11-16" version="1">MEEVESNAHPGIMSKVIPVKRESEENPSKGGNPTKNTKVKRSNGPYFHSANLSDNSMRNLMMYTWNIANAPIKATAIIAAKEINTCLIRSPTGGYAPGSIECPDKDLLRTADGLSSEESEWLESRNPITKERITEFLSDANLTDFDVDSFMNEVNDTIKIGIAFSGGGYRAMLNGAGQLLALDDRYDPSNEYGLGGILQSATYLVGLSGGNWLVGTVVLNNFSSVADIMNDDKIWDLEDSIINPDGWNVIKAAEYYTQIYSALDDKEDAGYDRSITDIWGRALSYQFFPDYEEAGVALCFSDIRNLSDFKSHNMPFPIVVADGRTPGSTIISGNSTIFEFNAFEVGSWDPSLYQFMDTKYLGTELKNGKPVDGTCVAGYDNAGFVIGTSSSLFNQFILQLSSANLPSLINGVIEKLLKSVSSDEDDIAIYEPNPFYKRDIGTISSISENETLFLVDGGEDLQNVPLQPLIQPVREVDVIFAYDNSADTDESWPNGTSLIYTYKRQFLDQGNGTLFPYVPDAASFRNLNLTSRPAFFGCDASNFSSLASEVGSSEQYPPLVVYTANRPMSYWSNTSTFKLSYELDEKLGVIQNGFEVATRGNLTLDEDFKTCIACAIIKRAQDRLNQEQTEQCKRCFETYCWDGAFVVFGLCVGVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B782</accession>
    <name>G3B782_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_94478</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B782"/>
    <dbReference type="GeneID" id="18250404"/>
    <dbReference type="KEGG" id="cten:18250404"/>
    <dbReference type="eggNOG" id="KOG1849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243454_0_0_1"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="5">
        <location>
            <begin position="1480"/>
            <end position="1580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1661" mass="188418" checksum="D5C8D09DBB3EC980" modified="2011-11-16" version="1">MDQPEIDLAQTNHRFESFLSSKYPAGSVLSSSCKHNVACNDTKSTKTDATHFIQSIFSHQDVKIIEKICPVAINGFICLYYLSPSSTGLINCLKKHESFIVKLISMNLLRESLAHLNVIYQALTSLVSKHPFRYVRENPNQAHLLLTGIQFDDQNYSHDTVKSTIAFHFLSLQTVLKYVSQNIHILSHSGTDDIFGIDSLSVLPDMFLTSSNFMKWINVHATPESSTKHYQNIITILNGLSTLSRKLSKLPKFNAEAVIAKLTLKIVEFQYLKNGKITTSSSNLKYDNIPGLQPFYEDLTKTVPELHNLSDVTWNSDDSPSLSKSELINLLQGISNNQSDLDTFNKAIIGCQIRDLFTEPSFLSACLGVLEQIDHDKYNDFISSVVTYMKNNYKSLKSLSSQCFELLDSITVHLKNLSDRSESIPFTLHIIAQLHFLFSKFKQYKRIRNLSNLLYNLAAKMPFSPMTVLCIEACIDYEYEIYNKSNSGSQDRDILQSKVEKTSQMLMEHGKVGESGSMVIVFLSTIQGSIRTIDDKNLLNSRPLAHLILGLVDLIPNFTVSLFGESSELSELFITALCINLFEHIQSSSVNQEVVANDIMTSIHLNDETLRLICLYYYYTIQELDSYLDISLANPREPFHYLIISGIQLHKTINIEWSEESIDQSIELFNQYCFLESNPNEYEIEILSCLVNYLKFNKLHKKLHQLLSPYLCSRDLTGNFQLQCFRFYLLLDLVTVSIYLENYQEAHSLLDSSGMLLKEIFAAGRTSSALSARGLAAWKLLQVQSYIEQRDLVLADNKYEMLLKFVKSKTEFNLSYHSASLGISEKLKNLLLVVNLNFTASELRSRQGRYTASYQNLKTGSKLLLSIIKKITVDVPVKDRVALRWQSASLMSSFCISMIKTSKLLGISREISHYIAELKKLNECNKFPLVNGINHFYLSDNFLLLERNETALSELKKGNQITSLNIDDSLSLLSVSSNLLYYLVEKSDEHIKAFSARQRELVQTLSLPGESFNTVSPFKELIHESQLHLSMFHSSIEPTYQASELDAVRVDVGQIMNSLVNIPAFSSILNSVFSSPCLVDNMVNESQHIRQITDALAEANTKLLSVISNHSFPVHALRNISNQMAHITSVVNSISPISETQRYEIYYLHDFIRSLPIKHERHMREESAAEPEDIFPLSGLKFEHKYDFLGFSEDVKNLLPANWTIITLDIDSGSDELVLARLSKESDYKPICLRLPLKRMMDHGSTASSLSFTGALDKLNAIIKRSDDSIKPQTTSKIRTKEDRTNWWRLRFSLDMKLKEVLELIEYQWLGAFRGIFGNHDEESIQFQNFSNKFHELLYKYLPSFPRDTQLNTQIVGIISQLHLSIGTDADSVEIEKAIVADLIYFIMDSLMYLGEENAYDEVNVDMFHHEFVELMNEFEDKASNPGEHIVLIPGPTCHSIPWESLGCLSDKSVSRMPSIDLLLETLKKNPTFTKQKEKSWNTMYLLNPGGDLVKSEARFSELFESMSSWEGIVGRSPSDNNKFLLDILKKDLFVYVGHGGCEQYIKASSLFKFTNSRKELPPSLLFGCSSGHITTNGMLEPHGNVLNWLTCGSPMVLANLWDVTDKDIDKFTMGVFKLTSLCGEGSSLTVTESVKEGRKYCNLKYLNGSAPIVYGLPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B791</accession>
    <name>G3B791_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_109220</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B791"/>
    <dbReference type="STRING" id="590646.G3B791"/>
    <dbReference type="GeneID" id="18246089"/>
    <dbReference type="KEGG" id="cten:18246089"/>
    <dbReference type="eggNOG" id="KOG2869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_3_1_1"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="385" mass="44106" checksum="372AF550577A1207" modified="2011-11-16" version="1">MKLVKQSFEKDSSGYTTLVPQDKEDLWQLYNLIQKQDDVKIQTFRNVSKKSGLSAVGGKDKGKQERKMVTLRLNVEDVEYNPSDESMRIRGKTTEPNEYVPIQSYHTGEVQLTKPITVYKHQWDQINYNIVIQSCSIEAKAEVGAIVFEEGIAHLCLITDNMTVLKTKIEKSIPKKRRGDNSNYEKGLNKFYDLIITTMLRNFDLDKLKVVILTSPGFMASSLLAQINAYAQKNDDKDLFRNKFKFVVAHSSTGYLQGLQEALQDPHLQKKLSDTKFTKQVQVFEEFEKNLNEDNDKAWYGRKECEQAIELGAVKYLMITDSLFRNDDISVRKFYIDLTEQVKHSSGEVLIFSSLHDSGKQLDALTGIAVLLSYPVPDLDEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B796</accession>
    <name>G3B796_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_135544</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B796"/>
    <dbReference type="STRING" id="590646.G3B796"/>
    <dbReference type="GeneID" id="18249885"/>
    <dbReference type="KEGG" id="cten:18249885"/>
    <dbReference type="eggNOG" id="KOG1418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013394_2_0_1"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="250"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="385"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="651" mass="73280" checksum="00E52422098D74E2" modified="2011-11-16" version="1">MSTISDLRTRDSHTTSSERRYIKISTDFSKSSHVLPLLSNGYSYHNSQQQEHELVPPLSFEKLLDAPLSTVSNMNIRPGERHFLFWFSVSSILPLISACLGPVGNMLSIVGLAESWRLDTTTLEPVPDPTAVQVLNSLSLAFGLIGNTSLLVNFSNPKAYIIAQTVSITCWVVASLLLVVGLVVLNAVYMTPGHTRSEGHWFSVFTVALYLMCTFTMSLNTIGYLLGKYPALLNLNKTEKALMRYTVALTVWLVIGTCSCRRLIDGLEYGTALYYCVVSVLTIGLGDIIPLSSGAKAFILIFSLVGVILIGLVIAMIRQVSHNTNNPVVHWHHMEVERKKCLELIEKNHVKLHEGDGFRIMRRIEHKCRSQQEVSSVILNLGVFAALWLLGAVVFRYVEGWSYFNAVYFCLLCLITIGYGDFVPVSALGHAFFVCWAIAAVPLMTMLISNLGDTLFDAYSLASLFGTIRMHVRYLFYGPPNKFKANSHSLHPVDSINRELGEEVLSTDSTTPSPEPAHSVHLRPHPHGLREKLETKIKTQKEDLVSILDFLNQLKPLLEDTLDSPSIEYKFDEWKALVHSLQRGTEESQHDTYYWLGDESPLRLPLKEPNYFITRIFFRIESELLRLIRESDQELEDLTAKKQQLPQGPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7C8</accession>
    <name>G3B7C8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_136178</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688414.1">
        <property type="nucleotide sequence ID" value="XM_006688351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7C8"/>
    <dbReference type="STRING" id="590646.G3B7C8"/>
    <dbReference type="GeneID" id="18249949"/>
    <dbReference type="KEGG" id="cten:18249949"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132818_0_0_1"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF15">
        <property type="entry name" value="HSP90 CO-CHAPERONE HCH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="144" mass="16613" checksum="790EE1F596AE5C0D" modified="2011-11-16" version="1">MVVHNPNNWHWVDKNCLPWSKEYFTSEFVNTEVEKDSYKFTLSSVNSVEGDCDVTQRKGRVLCIYDMTLTFGITGSKDEESFSGTITVPEFIHDQEEDDYVFNVSSESCNSEIKSLFLPVLKQKLMKFQGDLIKAHEKDVQHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7G2</accession>
    <name>G3B7G2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115728</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7G2"/>
    <dbReference type="eggNOG" id="ENOG502T623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2196612_0_0_1"/>
    <dbReference type="OrthoDB" id="4089884at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="108" mass="11837" checksum="A706A32C25A7EA54" modified="2011-11-16" version="1">MFKQGITTSTPVLRRGMAAPPRASYMSLISVPRAYSVKAKWNAVNKSIDKIGDESTTHSKIALKLVRALGGLSVIAVICSLIWNSQFVDQPAKPEVKLGDLQQDIRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7N3</accession>
    <name>G3B7N3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_115117</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7N3"/>
    <dbReference type="STRING" id="590646.G3B7N3"/>
    <dbReference type="GeneID" id="18247724"/>
    <dbReference type="KEGG" id="cten:18247724"/>
    <dbReference type="eggNOG" id="KOG3127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_0_0_1"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="177"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="327" mass="36141" checksum="0F90683C5AD2D622" modified="2011-11-16" version="1">MLIGISGTTSSGKTEIARYLTFQGFTHISIMDYIASKSPETSSNDVYTSSMEAHQFPTLDALVDHVTANWRTNFVLRDITSLHVLHALQKRPFFLHIAVDAPIKLRYQRYKSKHNSKVTLEEFVDAGDTASFAAGNPLAEINGLADINIINTSSSIKDLFIKLSELNLFDQSRLRPTWDAYFMRLADLAALRSNCMKRRVGCVLVRGNRVIATGYNGTPRHLTNCNEGGCERCNKGQGSGAGLSTCLCLHAEENALLESGRDRINEGSVLYCNTCPCLTCAIKIVQSGITEVVYAQSYSMDSATERVMGEARIVLRQYEPPRDGVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7P4</accession>
    <name>G3B7P4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_125990</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7P4"/>
    <dbReference type="STRING" id="590646.G3B7P4"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_82_2_1"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="185"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="650" mass="73474" checksum="B20C416A9E03389C" modified="2011-11-16" version="1">MPDRHKMKLFHFNKTNTEEDLTPSNSNQSHASNKKFLGFNIGKPDSHDVLASPVISNSIDNVQHHTVQAAGQSRSGTSSPHSPSNVINKEDSNHAFLKSNSMVELKKFFKPIKKGPTPKNYDNKLHSPSPMAVNNSHREHSSTSLAMLINQTSSQLLHHASQSSAGNHGKAPFTDDESPLVQKYGKIGKELGSGAGGSVKLIIRPSDSKTFAVKEFRPRRNTESLKDYTRKCTAEYCIGSTLKHPNIIKTIDIIHENNRYYEIMEYAPIDFFAVVMSGEMSRQEINCCLKQIIEGVAYLHSLGLAHRDLKLDNCVLTEDGILKIIDFGSAVIFKYPYDHYGNSKDSIHYCHGVVGSDPYLAPEVLRNSNSYNPQPVDLWSIAIIYCCMTLKRFPWKIPNPEKDNSFKLYSMEDDNWHDYVISNECHKLLLQQRKLKNTIVRSNKRKKSIQESGGPTPGNHDDMEQDHMEEPAPTSQSEQPEAGTEPSVPQEGEEEVLSGAKAEEIMAELKKIEDRLEEYENKKHEMKQRFIEAKQRAQGASESNKEEEEETESKKKSHKQIHGPYRLMRLLPHASRPVISKMLQVDPHSRASLEDILNDEWIRDIKCCTLNKVVRSEDNALAGVTFDEDENDVLVKGSPPHNHTIVFDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7W9</accession>
    <name>G3B7W9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_107669</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687846.1">
        <property type="nucleotide sequence ID" value="XM_006687783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7W9"/>
    <dbReference type="STRING" id="590646.G3B7W9"/>
    <dbReference type="GeneID" id="18245973"/>
    <dbReference type="KEGG" id="cten:18245973"/>
    <dbReference type="eggNOG" id="ENOG502RQ37">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150139_0_0_1"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="113" mass="12835" checksum="07340039D597EA8A" modified="2011-11-16" version="1">MVTLSGFILSGGLGLVARRLQLSIIGRVPTGGYKQITGYAASGAIFMGSYYFFNGVVDNNRQLLNRRLDVLREQRAKQELFNEFTQAEDHRITADKRQGRFFSLFDKYGAKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B831</accession>
    <name>G3B831_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_107831</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B831"/>
    <dbReference type="STRING" id="590646.G3B831"/>
    <dbReference type="GeneID" id="18245985"/>
    <dbReference type="KEGG" id="cten:18245985"/>
    <dbReference type="eggNOG" id="KOG2540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045000_0_0_1"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="247" mass="28034" checksum="9A1B454684B8E25F" modified="2011-11-16" version="1">MIRGAPLVLTPSRTLFQSSVLQDLSKDEKSNLYVENFERLQKEKIAQQKYRMQTSTNYATSLGIVFLALAFMAVPFYRALCKRTGWGGTPITDASKFTKDKVVPVDTNRRIRISFTCQSSGILPWKFTPLQREVYVVPGETALAFYRAKNNSKEDMIGMATYSVTPEQAAGYFNKIQCFCFEEQRLAAGEEVDMPVFFFIDPDFAKDPDLRTVDDIVLNYAFFRASYTDGELAAMPVAHLELKAEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B850</accession>
    <name>G3B850_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115811</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B850"/>
    <dbReference type="STRING" id="590646.G3B850"/>
    <dbReference type="eggNOG" id="ENOG502QVGM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2020657_0_0_1"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="123" mass="14006" checksum="F3F6B6E36B3583DC" modified="2011-11-16" version="1" fragment="single">MSQPSCVTTRKITLYRDDLVSVRRASDNDFNRTAAPDNLFFKSSLLSKNHAILSYTNSKVYIQDTESSFGTVLNNKYVNFGSKVEIKDGDSVGFVIYKPYNFIRQKLDEDAYIDIDLVPLSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B851</accession>
    <name>G3B851_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_131704</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B851"/>
    <dbReference type="STRING" id="590646.G3B851"/>
    <dbReference type="eggNOG" id="KOG1598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010293_3_3_1"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="286"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="423"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV62348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="588" mass="65428" checksum="AA865C09FC054535" modified="2011-11-16" version="1">MVLPANLCPRCGEPSLVSDITTNSGNLTCSSCGTVVHENPIVSEVSFGENASGGAVVQGTMVGSDQARVPISGRQNAMESRDQTMLTGRRNIKDLAASLNIPDYISDAAHGWFKLALNTNFVQGRRSQNVTAACLYIACRKEKTSHLLIDFSSRLQISVFSLGATFLKMVRTLNITKLPLVDPSLFISHFAERLNLDREKPNSTNQVISDAIKISFRMAKDSIVEGRRPAGVAGACVMMALRMNGFQKDPSEIVAIAHVSSDTLQARMDEFKRTSSGKLRIREFRDKSEQAEAAMPPSYTRNRERSKKDIAAAEGSLVEVSETDSRSATTHLETSADTQPQETDSQYVPQNTDSTVTNSQVTSLNTDSQDEDYMESRGEETISEIKVAKDAPSFVHEMASLGFNPELLQHDFERYKDIIEKGYSLDYPEPEPTSDSETADKEEEFDPNKPQGLVKYCKPSSYYLDLVSSSADLDDVELTEAEENWYLNSDEMAKAKEQLWLSMNKDYLLEQERKRLKAETDELTGNTSGKKKRRKTKADREKGIIDETLEALTGEPRTPADSVKQMMQRKTFSKKINYDALDNSGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B898</accession>
    <name>G3B898_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_124754</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687891.1">
        <property type="nucleotide sequence ID" value="XM_006687828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B898"/>
    <dbReference type="GeneID" id="18249051"/>
    <dbReference type="KEGG" id="cten:18249051"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="536" mass="60095" checksum="135277603835951D" modified="2011-11-16" version="1">MKKHLGLTGRPLVALLTVGYGLSFSWFGYDQGVFSGVLISEDFLQHFPKVKENHNVSGITSSCFSLGAFVGAIFAFTWGEKIGRRRTIIIGAFCNLVGAVLQVAAFQLPQLIIGRLINGFGMGITSATFPIYQAESIKAKNRGRFVVIGSVCNTFAYMLANWMNYGLYFTSGPLSWRFPLAFQLLFPILSIPIMFVLPESPRWLINHGRLEEGLETIAALWGKNLTIEHHEVKAEYYSIRAAIEEERAGQVPLMQVLTGRDKHKNLRRVILGAGTQFMQQFTGVNALGYYMPTILTVQLGFSAGTAKLLAACNATSYLGAALVCLIIIDKVGRRILMLYGSIGCCITYIIAAIAMKVGETRETYRMGSLTVAMFFVYYVIYGTSYAKVPWVYSSEINSIAWRTRGAAVAAATNWICGFCITQYTDIAVTNMRWGFYLLFAMIVLCYAPIVYFFYPETAKRTLEDINYMFDEYDTIFLGKHKELRQLSRPQAFIDAEFDRLSALRLVNNGKDYDEKLDTDHVEDIKSSKSKESVEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8D2</accession>
    <name>G3B8D2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MBF1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115829</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8D2"/>
    <dbReference type="STRING" id="590646.G3B8D2"/>
    <dbReference type="eggNOG" id="KOG3398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112609_0_1_1"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000015">
        <property type="entry name" value="Endothelial differentiation-related factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="150" mass="16435" checksum="0C156454CF01F84F" modified="2011-11-16" version="1">MSDWENVTVIGQKARIGGGGPRQTVAKTASQLNAARRTGNVIGTEKKYGTSNTKSNPEGQRLAKLDDTDDVVAVKKLDTNVGKVISRARQDKKMTQKDFATQINEKPQVINDYEAGRAVPNQQLLGKMERALGVKLRGKQIGEPLFKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8D6</accession>
    <name>G3B8D6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperonin Cpn10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_115831</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8D6"/>
    <dbReference type="STRING" id="590646.G3B8D6"/>
    <dbReference type="GeneID" id="18248043"/>
    <dbReference type="KEGG" id="cten:18248043"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_0_0_1"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="104" mass="11198" checksum="F713BE77C8D6B053" modified="2011-11-16" version="1">MSLLKSAQALKPLFDRVLIQRLKPQTQTASGIFIPEKNQEKLNQGTVVAAGPGVVNPQTGETVPVVLKAGDRVLLPAFGGSPVKVGEEEYLLYSDKEILAKIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8X6</accession>
    <name>G3B8X6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BBC1/AIM3 cysteine proteinase-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_108592</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8X6"/>
    <dbReference type="STRING" id="590646.G3B8X6"/>
    <dbReference type="GeneID" id="18246045"/>
    <dbReference type="KEGG" id="cten:18246045"/>
    <dbReference type="eggNOG" id="ENOG502QQMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045854_1_0_1"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="1">
        <location>
            <begin position="79"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="234" mass="26787" checksum="6C8926F64C45D32B" modified="2011-11-16" version="1" fragment="single">WWLKGLLPEFLAARIGSDLIYEVDSNTIEKRGNRTKVYKDYYILFYDLSSITFELEYELEDPRTSVKFTNYFTKGIPIIRKDLLDKYYKTYGSAILNSVSANSGVGTKSIIDHIFKHLDKSALPPIGNKSFGVTVYRSSNNHSISKVDDVRPGDILCIKNGKFLVHKGLGSKTVIVGDEQIFASVIYEYDSKKDKFKVVEVSNGQLKRETYKMSEMKSGQVRVFRVVGRDYVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Y9</accession>
    <name>G3B8Y9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prefoldin alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_109460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Y9"/>
    <dbReference type="STRING" id="590646.G3B8Y9"/>
    <dbReference type="GeneID" id="18246113"/>
    <dbReference type="KEGG" id="cten:18246113"/>
    <dbReference type="eggNOG" id="KOG3048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091867_0_2_1"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="150" mass="16964" checksum="25261166828F1C32" modified="2011-11-16" version="1">MSQRIDLGQLHPQQLVELKKSTEEEVTHFTSSLQALQTAQSKLKDCISSIDNMKSQQDKQLLVPLTSSLYLPGKVQDPEKFLVDIGTGYYVEKTSEDAKRVYTSKITKLNEDSAKLKEILVQKNEILNQLNMALRTKVLQMEKENAKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B939</accession>
    <name>G3B939_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_95352</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B939"/>
    <dbReference type="STRING" id="590646.G3B939"/>
    <dbReference type="GeneID" id="18250498"/>
    <dbReference type="KEGG" id="cten:18250498"/>
    <dbReference type="eggNOG" id="ENOG502QQTG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071622_1_1_1"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442814" description="Protein ROT1" evidence="11">
        <location>
            <begin position="17"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="248" mass="28663" checksum="9E9DB8DA942A341D" modified="2011-11-16" version="1">MSSLLVFFVLAVKVCCIGIDGTWMSKSKTVITGPRIYDPVDELIYEPSLPGVCYSFDKDGYWEQAIYSVTSNPIEPKAPTAAIIWQHGKYTIHKDGSMSLKPYPSDGRKLFSDPSKSKESIYMRYNQEEKIDHFDIEYDYYYGKYKLQLYSFDGSKKQPLWLEYNPPMMLPTSVLNPTNEKEKNALANINRKLKRSIENIGKTQLTRVDWIDIWMFHIFSVLGLAMAVAALAYVLTMLSKTRRKYKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B967</accession>
    <name>G3B967_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_125019</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B967"/>
    <dbReference type="STRING" id="590646.G3B967"/>
    <dbReference type="GeneID" id="18249071"/>
    <dbReference type="KEGG" id="cten:18249071"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="32"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="407" mass="45820" checksum="A9E2A45B6FA033D1" modified="2011-11-16" version="1">MTSGSFYDNVPLAETDPIVVVLQKYAKDPSPKKVDLSIGVYKPEDGDIKYVFPSVKKAKTEIYNHDEGHPYHSMAGYPQFVEGAQKVVFGDDRPREGRTTSIQTISGTGAIHLGIEFVKRLGLKDFYVGVPTWGNYQGMIESEDCNVEFFNHYDKASGTADVDAVLSTIDTMPDHSVLLLQACCHNPTGADYTQDQWKQICAKLKNRHIFTFFDIAYQGFASGNKDTDAWAIRYFYDQGLEFLAAESFSKNMGLYGERLGCLHVVSKNPKNISSVHSSLVSIFRSQCSFGPLFGARIASYLFTDFKEEWDQDVLTISDRLSGLRNQILNKFKALQTPGNWEPVVRQNGLFWFSGLSKEQIEDLTESYHIYIPLNGRFNVAGFNDSNLDYIIESIDKVVRKTQTEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9Q9</accession>
    <name>G3B9Q9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115404</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9Q9"/>
    <dbReference type="eggNOG" id="ENOG502QVK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1031010_0_0_1"/>
    <dbReference type="OrthoDB" id="3980909at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="281" mass="32196" checksum="1992FE1A10F37D5E" modified="2011-11-16" version="1">MKLQQEKPQLKQLATKRKQPESECSFNKRAKVVERNANGTIKNVDTDKIDPIERLLSLNNRYDCDLNTYLQQEQERVDEDSDDYDDSDESESDEYSSMSRRTSEINEVSLNFSKIVNDNLLRYEPFNFINQNSSFAMLNNHSVAQNVSTSVSKSEVPFFRSVNFNPQPKQNVIDELLNLDDEIEQPVGPKDPIQTNTTGDINATTTSVSDSEEEELTTPKNSPLMTNSKMCFNYRQHDHLNLSNFKPQPSDLKILNENSIFSGKLNETIGSGRFLINDFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9Y8</accession>
    <name>G3B9Y8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114821</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688664.1">
        <property type="nucleotide sequence ID" value="XM_006688601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9Y8"/>
    <dbReference type="STRING" id="590646.G3B9Y8"/>
    <dbReference type="GeneID" id="18247598"/>
    <dbReference type="KEGG" id="cten:18247598"/>
    <dbReference type="eggNOG" id="ENOG502QQPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007526_0_2_1"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="406" mass="45578" checksum="64BBDFB6B63BC39C" modified="2011-11-16" version="1">MNKDIEKTVTEIRGKFDTSKLSDFITNENAISSNPSVSLGIHIPKWQGPLTIKQFVFGQSNPTYLIIDANNNLSVLRRKPFPNSKLVSKSAHAIEREFFIINGINTLNERSSKKVPVPDTYFLCEDESIIGYVFYVMEYVEGASIKNPDMGDLAPAKKDQLWNSIMDTITAIHSLDADKLIESLPEKHFPQFKKPKSVTGSSASYFERQMKTLAGVSKKQGETVEPIPHFDVITQYILKNAPKDPVKKMLIHGDCKIDNFLFDKQLNKVIAVLDWELCTFGHPLFDLANFLQPFQIPNELNALFFAPLETDVGKENSASLQLIQDKLKLYKQKLGFVWDPNDPSNDPVKKWQVGFLFGLVRLSVISQGIAMRIKKGSASSANAAGFGSLYPYLAELVFGDIRPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA64</accession>
    <name>G3BA64_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_135954</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA64"/>
    <dbReference type="eggNOG" id="ENOG502RPWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_522725_0_0_1"/>
    <dbReference type="OrthoDB" id="4021409at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="521" mass="57547" checksum="FED3E1FC6A5127D3" modified="2011-11-16" version="1">MVTLYSMVQQQSLPNAWSGITTGVPSLDEKLLGGGLKGVYDFQVVPSSSSMEMVICEMLASYLKKGPDKRVVMINTFNDFPLQFMKLRKDFNSQWFSHQIQVYNLDTVSKLVIHLQKLNQSLSSDTIVVINNFHELLELYKLELSSCHQEMILRVHAANNKTIIDHTQQHEIEGTLPRMIEIPRISNLVRESPNSKYGSHVTYVYNLLSQLAYHKNSLVFITGSLDVKFKTWSLPSSSFMDTSASFDSSQATPPASALPSTGSRSSPAPTQYHPKGRLVLTFSDHQMSPGNRSSSGIFEAVITKRVMFFKDWYHKTPEATRKRSRKEKLVFGARVDGDETIYFEIVDNDLVDLSEVSKPLPAPSLVQVSTVSSSKPAANTGFLDNLSSSPGVFPSSMPLATSTSQGGPLTLGTSQPGLLATSTSQVVLVATSNEAVFPGQEVLAEEVEVQSVDEREEVELSEIETVEANNNENDNDNDNDNDNGNTDVDQEKGHRVLADSNHLDLSSIIQDSQDMGTPLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAC3</accession>
    <name>G3BAC3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_98649</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAC3"/>
    <dbReference type="STRING" id="590646.G3BAC3"/>
    <dbReference type="GeneID" id="18250792"/>
    <dbReference type="KEGG" id="cten:18250792"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063721_0_0_1"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="269" mass="31485" checksum="3B23D333C718D543" modified="2011-11-16" version="1">MDFEEEILLPNDYKYYHNNFDKSQFNLTLINSAIYLIKLLYLEDQEVEINPSNLRFFILQVLKRSKTSIQILQIACLYLMKLIKKRNDEKVKSLKNPKHLFLGLVILASKFNQDANYSFKTWVKILGLDSEDKNQIKLLKTLEIDLLQALEYNLYVSNATYENWCNVLLIFGYDFIKVQKILADSSKSEVVWESDSALIDSKLGKWGIFFSNLNVKNLDAVEIKFINYYLSQFNLKIFISNSFFVKRTIDDVNDADDSDLNDKVKLSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAH1</accession>
    <name>G3BAH1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_107599</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAH1"/>
    <dbReference type="STRING" id="590646.G3BAH1"/>
    <dbReference type="GeneID" id="18245967"/>
    <dbReference type="KEGG" id="cten:18245967"/>
    <dbReference type="eggNOG" id="KOG1299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013933_1_0_1"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="539" mass="62743" checksum="06F120F3DC58398D" modified="2011-11-16" version="1">MTMNLYKVNDTYFDKVFKDSNIDEAKGRVLLVDKFTMSIISICYSQSQLLSQDIILIDLIENFHQLDQMKHLNCIVYIKPVTDSIEFLTKELQAPHFHDYKVYFNNIINKNQLERIAESDKFEVVSNIVELFQDYLVINANLFTITSTSIIDETNKLVSLLLSIKKFPIIQYENNSLSLKKLSSEILYQINSNLNNNLFENLNYDTVPVLLLFDRFNDPITPLINPWTYQAMIHELIGINKNIVEINGEKILLDDQSDDFLSQSLYLNYGDLTELFQTKVEKFKKESNANVKTSNLVELKKILTRLPDFKKKSSNIMKHLNVLTELDAQISKQNLWEISELQQTIICNLDTKINVENSLIRILSNDSVSMNHKIKLILLYSIRFSGDHIGRFVSLLNEPSLVQLKLLNNFSKSFSSKIKHPKQEEENNFKKFFKNFSNTNEIDNIFLQYNPPLKDFLNDFLLLRADGNGHGLNTLVPDTLKESNIVQDVIIYFKNGVTYEEAKIVRDFNDTNRRFNLIIGSDKIINSNEWLEELYDFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAJ5</accession>
    <name>G3BAJ5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114897</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687587.1">
        <property type="nucleotide sequence ID" value="XM_006687524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAJ5"/>
    <dbReference type="STRING" id="590646.G3BAJ5"/>
    <dbReference type="GeneID" id="18247626"/>
    <dbReference type="KEGG" id="cten:18247626"/>
    <dbReference type="eggNOG" id="KOG4548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040204_0_0_1"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="272" mass="31874" checksum="E672789E7678D564" modified="2011-11-16" version="1">MIRNTIIRHYSSITATPVISSTVLLARNPVITRDLPAFEKSYYKYQNELWKRLMWTFPKWFYYRGGTLGDHRFKELNKPPVYNNPTMEFTDGRPEIRQSRDRRFKQELRLPKTYKQAEDGSEIVDEYSSDSLSRKINPNSRVTQADEKNDTTSLERKLSRSLYLVISEDNKTWTFPNFAVSQEHEIPLHKVAEDGIYNLGGQGLNYYNVSSKPCHVISSSDNNEFFIKSQIVSGQFKPASSTVKFMWLAKEELPKYLNNDYYNEIQHLLNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAK4</accession>
    <name>G3BAK4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_124094</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAK4"/>
    <dbReference type="STRING" id="590646.G3BAK4"/>
    <dbReference type="GeneID" id="18249002"/>
    <dbReference type="KEGG" id="cten:18249002"/>
    <dbReference type="eggNOG" id="KOG0548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_46_1_1"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="7">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="387" mass="43831" checksum="3D91D7841B3EB33E" modified="2011-11-16" version="1">MTVMATLMGIDMDGPPPGDFGAAPEVPTQKQEPTPAPQSKKEPVPEPEDVEMEEPEDTSKEDADKLKAEGNTLYKQRKFDEAIAKYTQAWETHKDITYLNNRSAAEFEKGDFETAIKTCNLAIDEGRDMRADYKLIAKAFARLGNIYLKQDDLNEAVKYFDKSLTEHRTPEVLNKLRSTQKEIKIKEIQSYVNPEKAEEARLEGKEYFTKGDWPNAVKAYSEMIKRAPEDARGYSNRAAALAKLMSFPDAVQDCNKAIEKDPSFVRAYIRKANAQLAMKEYAQVMETLNVAREKDTELGSKNVNEIDQLYNKASSQRFQNIEGETPEQTMERVSRDPEVVQILQDPVMQGILQQARDNPAALTDHMRNPEVSKKINMLIAAGVIRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAS4</accession>
    <name>G3BAS4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_94983</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688268.1">
        <property type="nucleotide sequence ID" value="XM_006688205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAS4"/>
    <dbReference type="GeneID" id="18250463"/>
    <dbReference type="KEGG" id="cten:18250463"/>
    <dbReference type="eggNOG" id="ENOG502S6M4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004904_0_0_1"/>
    <dbReference type="OrthoDB" id="3993678at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="722"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="956"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="956"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1096" mass="121985" checksum="E30F09C85CA37D39" modified="2011-11-16" version="1">MDAGTAAYTNKTRSPNTHRGDFGNNPVASHQQMYQSQYTSTNDLISPNFSMTSQSHMPGSRKASMTSVSAMSMNKLFRRNKGVDGGMAQFDEEKGADIQDLTGSVSFDDISHIRDRGPYGMTGTKTLDTTPIIPMVSTGGSSKNNIQYRKQMNHQMKMHLTNGARAMSLAGGNPMSNQNQDPRAMSFNSFSNGNPPRTMSMGMPQGSSTPNGPRAMSLRTGNPMQGYMPSGVPIHMNQMQMGMNPNMPRSMSMTNQNPMMNGVPMHGQMNARIPMNGMPTTNSQMVNGQSYGQPMMNGQMMSGQMMNGQMMSGQMMNGQMMNGQMYGQPMMNGYPMNGHPNGQMNSQIYVQGGNLSTPDNHNSSDSLMNVVEEREEEDQHTLNDVNSQTSKSRRIPPPLALEENEDDDDMVYKFDNEEDTDAFSLSRKSTLKKSNSMRLRKLNLFNNNDIEEETLPNTPTNSSPLNGYVNSNETSPSFNIRQSREMDVLSKSGSDEINKHLYGNQDKFNQLGATAVNESTSSDVYYTANDLNSPTKNLPSPNIRDSFTSKDSGKSASLQNTSTPEDSNKTIDVDLTSDIDTENEDDDTWNGTSSPKPISKQQSIRSLTENTAFHNFRSASFGKSSQLSNQVENVQIKSNDSSVKSSSSASKENYQTNPSTANTSSVNIEKAEIEKADMKNITDSTLVESPGNESIEIKTSEVVGAKEKRGSRINIFKRLSKSKRGSIAEDEDSFHESSARSSKRNSLTSTPTSSRRNSARRISLQAPPPVINPTPVKFTKEELGIMTANNDLLNELELVTTELASSIRRELKLESQIRKPSQGNSQGTASGVLEKEIREKSKALSDLQDKLTKERRLRFISEEHALLMEHGQTPSPLKLNYEKTELHRQLILKNDLCNQLQDKLNEYQSREDEISNQQMTTKEDTNLLNRYNELLKENAELKLSVVPELEKRLATLETNSQNLSPNRSPNLSPTHLPKNQRVLSLVQNSSFTSFNDSYNEDMNQSEDQFEINSLKKQRDDLREVVTKLNSSHSYEMKLASEKLKMLESRLKEQMSMNEKLRERYGNSSIASSSLNAKGGKLQGFTIVSPTKSLFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB09</accession>
    <name>G3BB09_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_125662</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB09"/>
    <dbReference type="STRING" id="590646.G3BB09"/>
    <dbReference type="GeneID" id="18249117"/>
    <dbReference type="KEGG" id="cten:18249117"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_2_1"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF10">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="49208" checksum="A0CE84EE11173ABA" modified="2011-11-16" version="1">MKFVFLSILIAVTSTYYYYVYTTLTGNGGTREALRHLSGLSGQDLTNIDILKKRAPKLSSNSYLSFPMGGRNRDQIGGENATIVMLVRNEELEGALSSMRSLEDRFNKDYQYPWVFLNDVPFTQEFKEQTTLMASGKTYYELIPEEDWEPPSFIDTIKLEENLKKSNKDVIYGGSRSYRNMCHFNSGFFFKQKRLLNYDWYFRVEPDVEYLCDFQHDPFKFLRENNKVYGFVTTIHEYENTIPTLWPTVEKFIEAYPDLIHPNNSLEFITSREVDLNYHVPMVNSSSEYNLCHFWSNFEIGSLNFWRSEAYSKFFEFLDQSGGFYYERWGDAPVHSIGLNLLADKNSIHHFDDIGYYHPPYMACPTSKDLISQKRCICKTSGHDGEVLTTPYDVQVFSCLSRWWRYGSGKKFLNEVDYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB66</accession>
    <name>G3BB66_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 20">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="19">CPR</shortName>
            <shortName evidence="19">P450R</shortName>
            <ecNumber evidence="19 20">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTEDRAFT_114967</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10573</strain>
            <strain evidence="24">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="19">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="19">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Endoplasmic reticulum membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Mitochondrion outer membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19 20">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="19 20"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB66"/>
    <dbReference type="STRING" id="590646.G3BB66"/>
    <dbReference type="GeneID" id="18247656"/>
    <dbReference type="KEGG" id="cten:18247656"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000036">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 19 20" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 19" id="KW-0274">FAD</keyword>
    <keyword evidence="3 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 19" id="KW-0288">FMN</keyword>
    <keyword evidence="2 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 19" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 19 20" id="KW-0521">NADP</keyword>
    <keyword evidence="12 19 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="21">
        <location>
            <begin position="60"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="263"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="438"/>
            <end position="441"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="456"/>
            <end position="458"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="471"/>
            <end position="474"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="598"/>
            <end position="599"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="605"/>
            <end position="609"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV62547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="679" mass="75717" checksum="7F5F681C69E831C4" modified="2011-11-16" version="1">MALDTIDFTVIGALVLMAVLYFAKDYVFPSDDGTNAGFTANIGGKSRDLVETITKNSKNCVILYGSQTGTAEEYSHKLAKELSSRFSLKTLVGDLSDFDYDNLNEVSDSVLVFFVLATYGEGEPTDDAVEFFDYLENEADDLSSLKFCVFGLGNSTYEFYNEIAKKAQKKLEELNATPFGLFGLGDDGVGSLDEDFLGWKDSLMESLKNELNFEEHEVSYQPSYELVDELTLTVDSEEVSLGEPNKSYLDSTKDLTKGPFDHSHPYLAPITASRELFSSNDKNCIHAEFDLSDTNLRYTTGDHLAIWPSNSDYNISNFVKAFGLGGKLDDVFSLKPLDSTVSIPFPTPTTIGSVLRHYLEISGPVSRQFFTSIAGFAPSDAVKAYAIKLGGDKALFASEVSAHKLNIADAVLKISNGVAWEKVPFEFIIETLGHLQQRYYSISSSSLSEKTCIHVTAVVETEKVESRYVTGVVTNLLRHIQLEQNNKTEKPAVTYDLNGPRDKFLKYRLPVHVRRSTFKLPTNPKTPVILIGPGTGIAPFRGFVRERVAIKKSSDAELGKTLVFFGCRNSNEDFLYKEEWPQYSKVLGDTFEMHTAFSREDPTKKVYVQHKLTENGAKIAALLKEGAFIYVCGDASKMARDVQHSLVEILAKDRDITEEKAAELVRSYKTQNRYQEDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB78</accession>
    <name>G3BB78_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_135457</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687678.1">
        <property type="nucleotide sequence ID" value="XM_006687615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB78"/>
    <dbReference type="STRING" id="590646.G3BB78"/>
    <dbReference type="GeneID" id="18249880"/>
    <dbReference type="KEGG" id="cten:18249880"/>
    <dbReference type="eggNOG" id="ENOG502S0ES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731589_0_0_1"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023278">
        <property type="entry name" value="Ethylene_insens-like_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116768">
        <property type="entry name" value="DNA-binding domain of EIN3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="67"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="378" mass="43347" checksum="744E16900AEC431C" modified="2011-11-16" version="1">MTLSNTSPTNVPVATPVWNSLSKNQTLMIRQILDGQHDLTSSVFLDIKPCLKDNRVFELKQFCGCRLKSQYEDLFGAMSQVICKVIAKEWIKVICPQKQGLFPYRMAETPSWWPSQVPHVEPDHLDKFNRIELLVSILRNKDIDLVKLKTSVRNLNALSANIEGWRYQVQKLIYELFYLSLYERFYFRYGVNLDLLAQCSDQERYLLHQNVVLIRVSNLDKVTLREIQPNMLNEDIFSLEVKEKPKEPKEPKKPKKTPVITKPKKAGAIAKSKGDVQTHKKHKQKKVATKAHTSKSKKKKVSVKRETSDDEQLFSDHYTCSTVRTGSLDITTAEDIKKEDESTTEYPVMRVASDSSISSISESEDNLTFYFGPSAPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBF5</accession>
    <name>G3BBF5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136115</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688349.1">
        <property type="nucleotide sequence ID" value="XM_006688286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBF5"/>
    <dbReference type="STRING" id="590646.G3BBF5"/>
    <dbReference type="GeneID" id="18249938"/>
    <dbReference type="KEGG" id="cten:18249938"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049048_0_0_1"/>
    <dbReference type="OrthoDB" id="10253329at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="451" mass="49921" checksum="988B2228008BA762" modified="2011-11-16" version="1">MASSTSGTTKQAEPRPVAGSPVGSSESSVPEKRKRPSKARKNKPVNAAVTESTNLNPGPSRKSNKPKKSPSPAGPKPQKATGNSKNKHVHKPRDVDVTKDYKYLQIKKLIRKFKPVTINGLPMKNIAQSADEPDEAKALDAYLQRFIKNQSDQAIYLSFIVIPSDPDFPFDLDSLKVSLCIPAEYPHRQVIPSIYVLNDEIPRGFAANIELGFKRITSLAAGKPLPSPEGELEEQIQLVDGKGLLSQVLTLDRFLEVFLKQEKRKTIKFVKGKPSKGSKSTSVSGSPSPSPAPTPVQQVHAVPVDENKRNQLLKQLHQKLKADIKLFNRSKLYTKYKIFVPVYMAEDLPQTWVDRGKIEILITVPLEYPSRSVTLEVPGQFSNATGNYVQYETNLIRNFDEFQAHGAAGASENLVARINYLANHLNVFCMDPAAYRSYTELTSQFGSALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBT6</accession>
    <name>G3BBT6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115699</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBT6"/>
    <dbReference type="STRING" id="590646.G3BBT6"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762899_0_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="363" mass="40306" checksum="F3E4B5D3D98F930C" modified="2011-11-16" version="1">MDHWGLGMVLFCIVYCGVPFSTSLVTDHGFREYKFNHSRFCGNNPGFKNNTDLHRGPGSEFKWASQFQSTGAARVAWKLCDPSIDHRYDLDLLFNDPWFQGLEMCVYEAEDQDVNPVVFPTVPSNASFSAVSTSAGSRVPSRRNTSLHNFNNASTAADLSSSFKSMLDFQSKEATNGQVHDNHEDGDDEDGDDKSIHSQSSLTHFHQAPPPLAADGCCSCEKPKSSSSMLDVVEKPKVKSMLDMAGSLNLPSLKEHDTYTENIKESKECVCDCHQEKSPANRPRAQSHPHPFRHVSSESLKRNSSQSSFTRNNSLTEWEDVLKPAEDLHLDSSGVCNLGYKIRKHHHLEVSGAAVSGALARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBV2</accession>
    <name>G3BBV2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_110078</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689300.1">
        <property type="nucleotide sequence ID" value="XM_006689237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBV2"/>
    <dbReference type="STRING" id="590646.G3BBV2"/>
    <dbReference type="GeneID" id="18246168"/>
    <dbReference type="KEGG" id="cten:18246168"/>
    <dbReference type="eggNOG" id="ENOG502RGDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158090_0_0_1"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="116" mass="13472" checksum="7E143910F0847EC1" modified="2011-11-16" version="1">MDADDPVPLIPWDEPMSDEKEPSAESLRLYGYALVVGTWLLFAVSINSFFELWRFVIAPLSMDSRSQQLHQRLVGFFSTVDQYVLRSFGIYVVGWWWALVSWVGLKLFKHSKGNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC91</accession>
    <name>G3BC91_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP synthase f chain mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116168</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC91"/>
    <dbReference type="STRING" id="590646.G3BC91"/>
    <dbReference type="eggNOG" id="ENOG502S739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152700_1_0_1"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="100" mass="11031" checksum="DCD563FADDF3ABE8" modified="2011-11-16" version="1">MSFIIRRQLSTLIPPKIASAKNIGSNPNAKRMAEVVSFYKKLPTGPAPAPKKPITPLAKYKAAFFDGDNASGKPLVHLAVAIVILGYTWEYQSHLKHHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCC6</accession>
    <name>G3BCC6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein rhp7 treble clef domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_128435</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCC6"/>
    <dbReference type="STRING" id="590646.G3BCC6"/>
    <dbReference type="GeneID" id="18249305"/>
    <dbReference type="KEGG" id="cten:18249305"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006598_2_1_1"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF281">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="627" mass="70635" checksum="7F98BAA4341CCDB8" modified="2011-11-16" version="1">MSRRTKNTGSNVRGPNSALTEFLRVEGITDAFRRRREIQQDQAIEGITSGDSSTESSVAPTAAQEVSSNPLRQSSGTASRIENPSEEEDEIVQMRAAARRKRRAARRGSDGDDDFIGADDDDDDDDEDDEDYDSVARSASLGNEYKQSGQEDVCVECEKLFELTVYSRYDKVRRGYLCEDCNQELKQREKNTRRNQQNARRKRKKVAQALLDKTTVSIPTLQDICIKYITSNIDQVEALGGIGSINMNKISKILSKNRSLNNETMTLFLNPDSKSLEFWDCSNVDSDSFNKIASYCPNLESLTLFMCGQLHNDNFEYYSDKLTKLTELNLNGPFLINEVTWQDFFESCGKKLEKLEIRNTHRFSNDSLIGMLENCGKNLTSLKLSRLDGLTSAEVYELIPHYLTPNSLTHLEISYPKSEELVTDELLINLLAITGGSLVSLNVDGCTSLTNNFINEGISSFCKTLTHLSMKGLDQINEEANFKGFNEINGGLISLDLNKCIEMTEAVIYDILKQSCTTLVELNLNSLDNLSKNFFWQVLTDDYEELKVNFKENNADDSLTFYSGLSFPLLTTLNVGFVRSIDDQILNLLSKKCPKLKILEVFGDNRCTYKAKTRSDMIIIGRQGDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCL2</accession>
    <name>G3BCL2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_111599</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCL2"/>
    <dbReference type="STRING" id="590646.G3BCL2"/>
    <dbReference type="GeneID" id="18246298"/>
    <dbReference type="KEGG" id="cten:18246298"/>
    <dbReference type="eggNOG" id="KOG0186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029274_0_0_1"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="70"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="419" mass="46900" checksum="B6FDF1EF67273534" modified="2011-11-16" version="1">MPQVPDDVSYLKAAKWSELLSFLCIGAVTINKPILNLSIKAFPYVPMFIIKPLVYKIYCGGETVKDLFTTSDRLKQRGINNMMLSLTIEAAEGNKHIDPNYIVDETNKSITDFLIPNTVAKMKEAENINSIPPSYVALKPTGFASNAAEVLRNYQNNTEFDDLVNKISTVIETIYTANLKLCQQYPARSSPIVVGVIDAEKHDLQPGVYELQRRLYQKFNKPNQPVSVVGTLQMYLSESAQLLALEEKLAKENDYRLGLKLVRGAYIHSEANRNTIIHKSKDDTDMNYNSGISYCIENIMAEKNNNHSTIGHLVVASHNAESLNLATDKLNQSNDSNPNKNNVVLGQLLGMADNITYNLIKNKGVTNVIKYVPWGPPVETKAYLLRRLEENGDAVKNDTGFNLIKAVVAVLFRRLFRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCQ2</accession>
    <name>G3BCQ2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramic acid 6-phosphate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_96295</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCQ2"/>
    <dbReference type="STRING" id="590646.G3BCQ2"/>
    <dbReference type="GeneID" id="18250599"/>
    <dbReference type="KEGG" id="cten:18250599"/>
    <dbReference type="eggNOG" id="ENOG502QS2J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049049_1_0_1"/>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009750">
        <property type="term" value="P:response to fructose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000014">
        <property type="entry name" value="N-acetylmuramic acid 6-phosphate etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00274">
        <property type="entry name" value="N-acetylmuramic acid 6-phosphate etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003915">
        <property type="entry name" value="PRK05441.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009222">
        <property type="entry name" value="PRK12570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF4">
        <property type="entry name" value="GLUCOKINASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22645">
        <property type="entry name" value="GKRP_SIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="58"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="451" mass="49334" checksum="677C6090C71CAA69" modified="2011-11-16" version="1">MTISGLENLATEMQNPHTNDIDQITTDKLLQLMNREDHRMLESVRNVIPVITQVVEHLAPLVKRGGRLIYLGAGTSGRLGVLDASEIPPTFSAPENQFVGLIAGGDTALRKALESSEDNEMAAAKDLQPLNLNPELDTVLGIASSGRTPYVIGALRYAKSLGCVTVGLSCVHDPEIGKHGLSDFLISPVTGPEVVTGSTRLKAGTATKLVLNMISTATMIKIGKTYGNLMVDLRPTNIKLRERTRNIFKQACGGEYYIVKEGIISKFAASPTDLEENKFIDHILDYSQGNLKLAILVAKRGVDIYEADKMLAKADGNLREALQQSGTREQLPISKMPPTKQFDKYNLCIDILTNEIQVVLFNKRTYIHKQVMIENLGSDLSETIDKCIEEISCNQHFSSNMLESIKVGTVSGLENTILNALFLNYGIDSSRVAILSGQSDLCGLVLTLFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCV3</accession>
    <name>G3BCV3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116268</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCV3"/>
    <dbReference type="GeneID" id="18248223"/>
    <dbReference type="KEGG" id="cten:18248223"/>
    <dbReference type="HOGENOM" id="CLU_149546_1_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442806" evidence="2">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="56" mass="5206" checksum="A1FEC0D2BFF6968E" modified="2011-11-16" version="1">MQFKSVLVALTAITAVQAANASNGSNGSSSSDESGAAIVSTGLLGAAAAAGVALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD02</accession>
    <name>G3BD02_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_96322</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690099.1">
        <property type="nucleotide sequence ID" value="XM_006690036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD02"/>
    <dbReference type="GeneID" id="18250602"/>
    <dbReference type="KEGG" id="cten:18250602"/>
    <dbReference type="HOGENOM" id="CLU_564985_0_0_1"/>
    <dbReference type="OrthoDB" id="4024635at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="483" mass="53237" checksum="EC836E852689EB9D" modified="2011-11-16" version="1">MSYKQRLSSCDAPSPIPASLDSLDLSHVGYSHKADFKYQLEDIPGLPIFKKNGKFKRFVTRDPNQKRVLSMPLLSSESLDKDLPIIPSRCVTSFNRFSMPQLDEQLSEPLVEFQSTPPRPQTMYIVPPHRPFSNQPLRKYIVDNDDDIDSLFSTNKSGTSNITTYTTDDIETAESILDLVQAYGNDSSSDDLEEAGDDSSSIYSQDSKISGLVTNYIEEPDVGLPFDEDVYSIIDSLFDDVPVVPVAAKKLPSIPQQSPSPENPPIISLDIKKSRNKVSFDDNNIKSAWSKADSSSGSTGVFPSPFRRPVSMNLDLMRPKHQVYQRPVSMMSTSNVSVSTCVSTNTVQIAKSDIKNIVRQRPYSYCLDSPSTYNYSRYAITPQPKITSNPYSSTLAPVVGSVQSSDANKVIPPQTPITPTTGQFTPQGSPKLLPPTPPPKQSQSRAVSLPVTPPGSPASKEERMKSTIALFLKQERGRKVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDA0</accession>
    <name>G3BDA0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">CANTEDRAFT_110568</name>
    </gene>
    <organism evidence="31">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BDA0"/>
    <dbReference type="GeneID" id="18246203"/>
    <dbReference type="KEGG" id="cten:18246203"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_0_0_1"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="26" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 24" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 25" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="28">
        <location>
            <begin position="156"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="29">
        <location>
            <begin position="1128"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1357"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="1473"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="27">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="1373"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="23">
        <location>
            <position position="1311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1780"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1781"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1782"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1880"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1881"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="25">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EGV60278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1894" mass="207722" checksum="962601A0DD5BB260" modified="2011-11-16" version="1">MRPEIEQELSHTLLTELLAYQFASPVRWIETQDVFLKDNKTERVVEIGPSPTLAGMASRTIKAKYESFDAALSLQRQVLCYSKDANQIYYTPDPADLESDKPSITKSLNANKADTPAATATESAPAASPAAPVPAQAPAPVPAPSGPVASVADEAVSAGLIVQVLVAQKLKKPLDAVPMSKAIKDLVNGKSTVQNEILGDLGKEFGSTPEKPEDTPLQELAEQFQDSFSGQLGKTTSGLVGRLMSSKMPGGFSVTSARKYLDSRYGFAAGRQDSVLLLALVNEPANRLGSENDAKSFLDGMAQKHASMAGISLNSGAEAAGGAGGAAGAVIDSAALDAVTAENKNLAKQQLETLARYLKVDLNKGAKSFVKEKEASAVLQKELDLWEEEHGEFYAKGIKPIFSPLKARTYDSYWNWARQDVLSMYFDIIFGKLTSVDRETINQCIQIMNRSNPTLIKFMQYHIDHTPEYKGETYQLAKKLGQQLIDNCKQVLDVDPAFKDVSKITKPHTNIDARGQIDYNEIESPSVRKFEQYVYEMAQGGEITKQKSKPTIKDDLARVYKAIVKQQNLSADTKLDFQSLYTQLIDYIDSSKEIDNRAIATGTATPVEEAEDILSSPATSDDEIASLPDKTSILQPVSSTIPQETIPFLHIQRKTREGWEYDHKLSSTYLDGLESCAINGLTFKDKHVLVTGAGAGSIGAEVLQGLISGGAKVIVTTSRFSKKTTEYYQTMYSRYGAAGSTLIVVPFNQGSVKDVNALVDYIYNDPKQGGLGWDLDIIVPFAAIPENGNGLDNIDSKSELAHRIMLTNVLRLLGGVKSKKSTDTRPAQVILPLSPNHGTFGFDGLYSESKISLETLFNRWYSEDWGTRLTICGAVIGWTRGTGLMSANNIIAEGFEKLGVRTFSQKEMAFNILGLMTPELTQLCQEEPILADLNGGFQYIDNLKDVTTKLRTDLLETADVKRAVSLESSIEQRVVNGENVDNNYAKVKVQARSNMKFDFPGMKSYKEIKEIAPDLEGMLDLESVVVVTGFSEVGPWGNSRTRWEMEANGEFSIEGAIEMAWIMGLIKYHNGKLKGKPYSGWVDAKTQAPVEDHEIKAKYEEHILEHSGIRLVEPELFGGYDPNKKKLIQEVVVQHDLEPFEASKEVAEQYKLQHGDKCEIFEDEESGEYSIKILTGATLYIPKALKFDRLVAGQIPTGWNAKTYGIDDDIISQVDPVTLFALVATVEALLASGVTDPYEFYKYIHLSELGNCIGSGMGGMTALKGIFKDRYEEKQVQNDILQESFINTMPAWINMLLLSSSGPIRTPVGACATAIESVELGIETILAKKAKICVVGGLDDFQEESSHEFANMNATSNTYDEFDHGRTPAEMSRPTTTTRSGFMESQGSGVQVVMSADLAIKMGVPIYGILAMSATASDKIGKSVPAPGKGILTTAREYHGDLKFPSSKLNIKYRARQLKNRLAQIESWRESEIDYLYEEAELAKESYNDFEEEFVVEEFLAERSEEIDREAKRQIADAKRQWGNDFYKSDPRIAPLRGAMATFGLTIDDLGVASFHGTSTKANDKNETLTVHSMMKHLGRTEGNPVYGVFQKFLTGHPKGAAGAWMLNGALQILQTGLVPGNRNADNVDQILQEFDYVMFPSRSIQTDGIKAVSVTSFGFGQKGAQAIVIHPDYLYAVLDQASYEEYAAKVVSRNKKTYRYMHNAITRNTMFVQKNDAPYVDDLEKQVYLDPLARVSEGKDLKFANKTIQASASYISESSNNIAKALSTLNKSNKGVGVDVELLSSLNLENETFIERNFTKGEQEYCLKSPDPRASFTGTWSAKEAVFKALGVKSQGAGAALVDIQVVRSATGAPKVNLVGAAKAAAEKAGVKNVSVSISHDDFQATAVALSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDC9</accession>
    <name>G3BDC9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_128713</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDC9"/>
    <dbReference type="STRING" id="590646.G3BDC9"/>
    <dbReference type="GeneID" id="18249327"/>
    <dbReference type="KEGG" id="cten:18249327"/>
    <dbReference type="eggNOG" id="KOG3060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065213_0_0_1"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="302" mass="34859" checksum="37DA728E5FDF6D0A" modified="2011-11-16" version="1">MSGFKFDLVKAKLLAIARTGVFVNFSPSKVDDTYNELKQLLINGDSIDIKDVYDLYELHVYLSLITNHDVEAKSYIDRIIDQFGDENSQRITLLKSIYYESQGSKKEGASILGANKNELRLSRRLLTYNRENLKGEEYVSNLVFYLNLQPADLIAWAELADEYAKLGHYDKSIFCLKEVLLEEPVAYPILYKVGLLNYYLFLQNFKEAIVKKDALVELMKYLVDSRNSWLRTIEVCKDHKASWLGVYLICNQSSFNDKLDKLANVKEFEKYKADIKRLSGPSAQKVMELNNITEKELKTLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDL3</accession>
    <name>G3BDL3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116382</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDL3"/>
    <dbReference type="STRING" id="590646.G3BDL3"/>
    <dbReference type="GeneID" id="18248276"/>
    <dbReference type="KEGG" id="cten:18248276"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_2_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="35"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="13">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="463"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="263"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="736" mass="82408" checksum="4192829E2E98F94E" modified="2011-11-16" version="1">MTTIYTSDIKHHRRAPPPPSQATEREIKLSINSSSKRQSGWVHIKDDGIFTSFRWNKRFMVINDKTLNFYKSDNTLNVSPDLSFPLNLIHSINLKNNTGYTKNSYSFEIIPKNNNNKPILISIKHNNDYLDWLDAFSTKCPYINVNSSSSSSSVVENLGSLNIGESSSNQVSNPINFTHKVHVGFDPASGNFTGLPETWKSLLQHSKITNEDWKKDPVAVIEVLEFYSDINGSNANTPINSPYLNHLKGPGTSSFANLTQPPKNFKPTRQAPKPPVPYHLSKGNETAGGAGTTATVSPLNNLLNNSGSSTNINNPTLAPIRRAPPPPREKVGQLPLGSSSVVPKQQPPTLPGATKPSQFNVKNPPPQVQVQPSQKQSQQKSHYVTKPVSPESQMQKPAPSDYPHKAHAQQETVLESNETKPLQIKPKQKSAKQLKREKERLNEMQILAKLKTVVNSNDPTPLFKIIEKAGQGASGSVYLAEMVSNQQKVAIKQMDLNVQPRKELIINEILVMKDSQHKNIVNFLDSYLRSSNDLWVIMEYMEGGSLTEIIDNNENKLTELQISVICRETLLGLQHLHKKHIIHRDIKSDNVLLDSRGNVKITDFGFCAKLTDQRNKRATMVGTPYWMAPEVVKQKEYDAKVDVWSLGIMTIEMIEGEPPYLNEEQLKALYLIATNGTPKLKHPEFLSTSIKKFLSICLCVDVRYRATTDELVKHSFVNNNGTVEDLAPLLAWKTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDM9</accession>
    <name>G3BDM9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116390</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDM9"/>
    <dbReference type="eggNOG" id="ENOG502RWFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504305_0_0_1"/>
    <dbReference type="OrthoDB" id="4096756at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="540" mass="59817" checksum="55F701AD4E7123BB" modified="2011-11-16" version="1">MNTDSEAISPSRHKRLGTSEFQSPTKPLHSIFRRQNSFDSADSSTSFGSNRRSISPIRKSLSNSLYNPTSPSRLSTTAGKLRNLVPMLSGSRSSVHTDVSQITSLTSQLFQPVQDDSTSIRDFADTSGDDDDDSGSKYSASVESILQEYTDDSPKKKFFFNEHFDEKSLASVKRNISTKSVIERTLNETRSDFEGTSGSHNSSVGRSSKDFAIFHDASGFIGSSSSNRSSSANPAANKHMTALSSIDNNTSSSSSRNKIYYDTTTYDNLNETSERPLFEQKSFINSRTSLNSGELLSKLNRSLSDVADRHVHPSRAVVAYRVKNSQSPKLIQIPNPEPAHYHDSDISSENSIGSITVPTTRGIVSKAPKFGSAYLGSARRPPPQAPVQDSLYKYNQHEDMYQSQTTKTVVDGFPAIGTAQSNVTSPDYTDYDESYFGNLEEKQSQEYVAPQHFSWSYFVLLMGIGLILPPIYFLVSLGIFDKLKSSKNYYNGIYYQQQLSVNRGRVVKFSPRQKLVSFFVGILWFSIVLGMIGVGFGLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDR0</accession>
    <name>G3BDR0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_95810</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689570.1">
        <property type="nucleotide sequence ID" value="XM_006689507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDR0"/>
    <dbReference type="GeneID" id="18250542"/>
    <dbReference type="KEGG" id="cten:18250542"/>
    <dbReference type="HOGENOM" id="CLU_936888_0_0_1"/>
    <dbReference type="OrthoDB" id="10666806at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="297" mass="33171" checksum="E4BAD9292AD26C95" modified="2011-11-16" version="1">MMSLVLSPSENSIAQRVWKSLNLYVSIPTNHKNPQITLSYEQMQKLGHRVLSNCQSNNDQLGLVNHYFTHLIHILTIVINNLHDPQPSDSQLVARFAKINARIYDLDLVGFCEALIVSLHELVPVSVSEEIVMLKFLNQLLTYINECSADPVLELDDPRLSYSDSNLSSTFSLAHDIDDDQMDHINDVTILPNKGTTSNTIDIDSVENLDDHDNVTSSMTSDSTSDEDESYDYLNSFSSSATNSESKPQRLSLQKSRKRLSSLNLSKPSRRSSMSTLRTVSTTASTGTTNKQDCIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDV4</accession>
    <name>G3BDV4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116441</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689604.1">
        <property type="nucleotide sequence ID" value="XM_006689541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDV4"/>
    <dbReference type="GeneID" id="18248307"/>
    <dbReference type="KEGG" id="cten:18248307"/>
    <dbReference type="HOGENOM" id="CLU_966428_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="288" mass="33592" checksum="AB04390A7C2D9F04" modified="2011-11-16" version="1">MKLEKLRELFKDVDHFDPIVNDTYQRRVEDSMDIIDRFQEQATEQIEKLQKSLVSTQPYHIEFAEYERKREVIARYRTYNKVLFFSDKSDIINESATNTILDELVTDQIRSHNALVNENKYQTEAIGQLQAQERSYRELLERIDEVISTKKTELLSLQQQSLHQESDIKDKVRLQLDAKRKECKDILTLLRTSLHRIIVKYFSFSDAVAGTEEVEWLAEFVDLLIENSTSGQYIDIRELDTVRRELVNNLVLSNIIETAAPSDSTSGDTDADLKSISTHPLVKLRDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE47</accession>
    <name>G3BE47_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_111556</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE47"/>
    <dbReference type="STRING" id="590646.G3BE47"/>
    <dbReference type="GeneID" id="18246293"/>
    <dbReference type="KEGG" id="cten:18246293"/>
    <dbReference type="eggNOG" id="ENOG502QTA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006926_0_0_1"/>
    <dbReference type="OrthoDB" id="2110361at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="894" mass="101770" checksum="8F279463E5100517" modified="2011-11-16" version="1">MIAEEIAGDSERGETDKNGKQKKRTNMACIRCRTRHVRCPGGDPCKKCQLAKTKCEYVEADKKIVVSMKYLSKLHDDIARLKKENATLRTNLKNEELRRTGENGSRIGNSFEYHTKTPHNQLLFNEVTSSAFNTGEIIQPSLDKYGRLIQSRTGERIYVGSSSMTLFGLEIQNMVPAAYSPSNNGNAANSPLSTMSESGAGADKREAEVMEKEGNAYKITLAKTNTRPGLSINFTLPSYSYAMLLVDNFINYNDGCFYFFNEGLVKRFLMNLYSGNTEENKKIMRRNLNLTKRYDADENSIKNDRDDDTILETMWFCKILLIFATGEMYLGTESDVHIKTAKHQYKAENKKQKKEANTNRTFPKNTLPGSGYFYQASELFTGLFASGAIDNITKDGGIEVMLLYAFFLQVADCTIASYFYFGLALRSALILGWHVDSEQNTLDRFELEHRRRLWWTVYMYERMLSSKAGLPLSFSDDSVSTELPKDIDMSLVDFPADDSDVRGYYIFPSAEYINNCVTITQINAIILSCLYTKQPTINILPVVSDLVHRLMNWKNSLPEFLKIDFQSEDLKISRLIVNLMTEYFQGINLAVRPLLFHFASKKLKELQTQNNVNKYVDLSRYSKNVITLLNASFQASINTVRSIWALLPDNMVALFGWMDREYLFTSALTLILFNSSFGLHDATKEHLDHALTVFTKMKKLGNYPAAVRRAQLLKLISILDFNRVMRDLLTKHDDEGLFSTSVSPNDPEMPVEPPTLNMTNHEKTDQHQSNDSIGQNELNINNELEPLISIKFDAYDMNELETLYPKNEAEGIEGFTEFNEEQKLWHEITNDAVWLQHAPNKPASSATPGNEFNESSDDGEEMTEVLEAFDSKVTQDTPGYGDMLNHEFHDLMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE95</accession>
    <name>G3BE95_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_127772</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE95"/>
    <dbReference type="STRING" id="590646.G3BE95"/>
    <dbReference type="eggNOG" id="ENOG502S0ZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042296_0_0_1"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="480" mass="54333" checksum="65FFDD91B4767932" modified="2011-11-16" version="1">MSLPIEDPVFGGVNYTASAYMMELLYALGDGRDPGTGIKPFSRWSKNLMGPKLPEALLNYNVGMQVNLLGGYPISKDIVPSAIFTAVFVIFTLTHLAIFVVNCGRNHYFYLSLYWVGYGILRSLGFGLRILWAHDITLVDMAIADECMLVLGNVALVASNLVLAQRLFSWRHPVGGARRLFRYTMYGMYLVVAGVIAMTVTASAVPYLYYLSSKVFWHYKICVMVSSILIILYSLTAISLLGLSYFFKPTRKDENLYTYQPWWIESFSPFYFVKKGAKLEAEETFMKRNHNHRHAVRVIAATHHHYNMVEGLTNQRGDLTHNTSILIIFISTTFLFLASVVRCIAVFQANAAFRGGRVCEPVLMYIVWGLLEVVINILFLVGRVDLRFYRPDKLPKKVRAIITAEQSVMVSIITAEQSFFASRNISQNVSDEEESEAEDMDDFSYTESPPSRTAAPPGYEFKNDKLEESTSNDNESDFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEN9</accession>
    <name>G3BEN9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_110409</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689154.1">
        <property type="nucleotide sequence ID" value="XM_006689091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEN9"/>
    <dbReference type="STRING" id="590646.G3BEN9"/>
    <dbReference type="GeneID" id="18246193"/>
    <dbReference type="KEGG" id="cten:18246193"/>
    <dbReference type="eggNOG" id="ENOG502SARN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088651_0_0_1"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV59940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="174" mass="18866" checksum="1BDC50DF632AE7AC" modified="2011-11-16" version="1">MSDYIANTVPQLKELLKARGLPLDGKKADLIARLSESDGVAEAPAEPQPEIEATPAEPKPKDPSPVAEGETAVSAPAATEAVVEKPKVLTPEERKSLAVDLLTKKIKRAEKFGDEASAEASRKDLARIEKFGVEPGTTLAKEIGLVDKSFNSGLAERSFKKKKNTKFKKFNRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEW2</accession>
    <name>G3BEW2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_128008</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEW2"/>
    <dbReference type="STRING" id="590646.G3BEW2"/>
    <dbReference type="GeneID" id="18249274"/>
    <dbReference type="KEGG" id="cten:18249274"/>
    <dbReference type="eggNOG" id="KOG0433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_2_1"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="44"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="680"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="919" mass="105964" checksum="65147A9C590D2595" modified="2011-11-16" version="1">MRSIIRLRRCHSTYSGTLHLPKTNFSPKIPSGEDAAKIDKLATSNLYKWQKSRSTSKFILHDGPPYANGDLHLGHALNKVLKDMMNRYEMLYNNKSIDYVPGWDCHGLPIELKVTKPGLDPVEIRQKSRDLANKMILKQMEQFKKFSIMTDWSTIYKTMDHEYEVNQLKLFKTLIKNKLLSRQMKPVWYGCDTKTALAEAELEYRKHKSIAVYVKFKLVDDPTTSLLIWTSTPWTLLGNKAICINENLNYIKLSNESESLIVQEDMVQSVQALNLSFSHVESVATNDLLKLKYLNLYNEHCPVLHGDHVNNASGTGLVHTAPGHGMEDYLIGLKHNLTIDSIVDDEGRLVDPGYPNDLPVNRVETIKKCIKIYKDLGILYHVDYNFVHNYPYDWRSKSPVIQRATPQWFISVDKIRDNTLEALSKVDFVPEIGVNRLKAFISNRTEWCISRQRAWGVPLPIVYYKGEPLYEVVDHVVEKFDEFGTDEWFGNDDVLKWLPSNYVEENSLDVKHLVQSKDTMDVWFDSGTSWSILNGQIADVYVEGSDQHRGWFQSSILNKIISTGENSEFQSVSPYKKIVTHGFILDKNNDKMSKSLGNIIAPSDLIDGNMKTGVPRLGIDGLRLWIASSNYVNDISISNEILKRVLDNLKKFRVTFKFMLGNLNDSENISANYDTLSDLDKFILSNLKKLQQNCETNFKEYNFQKALKDVNNHMNNDLSSFYFDISKDCLYTDSIDSIKRQNIQFVLKQVLKTYTGILSPMLPNLTQELWTNSRTILKQTEISPFMLPYDYYKLPETYNDPQIDSQFHNLMQLRESLFSRLEALRKEGKFKKSLELNLYIQTNDDFIKKNSGLLDDFFLVSKVAINNSIPQDPLDHFEQDTNKIFITLADEHKCPRCWKFTATVEDELCHKCASVVNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF34</accession>
    <name>G3BF34_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ORC6 first cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116694</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF34"/>
    <dbReference type="STRING" id="590646.G3BF34"/>
    <dbReference type="GeneID" id="18248404"/>
    <dbReference type="KEGG" id="cten:18248404"/>
    <dbReference type="eggNOG" id="ENOG502QS52">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060403_0_0_1"/>
    <dbReference type="OrthoDB" id="5367324at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016811">
        <property type="entry name" value="ORC6_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022941">
        <property type="entry name" value="ORC6_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="381" mass="42882" checksum="9B5D27013B49C7D1" modified="2011-11-16" version="1" fragment="single">MSLHVKTAIKNVALGISDPIPAQVLSYCERLYGQTLHKRLPKSYESARYHICAFLSVEKYSSTFNLPSPDFKRIPIPPKKCLTTLEDFRLYLDSVKSALSTPTKQSPHSSPLANLPIPQSPFQETSSAMGYTSVQLNGSPVKLSPSQSVPRGRKRGSLHETSTPTRSSPLKKLRAIANETPSAEQSPSIVRSIASPFLTPNSKAVKPFKVTEDSVSIVQLIQLCNTFYMPASVTVSIIQEFINQRHKFVKKSDWYLACGLIYAASLRINHRIIKDKPDYGETLVTQFIRQRSKLKKPNLIYWNTLINEGVKNQPWIIEIENTFMFGVQSSQAEKKENDYRLGIGAETYDRLGMMNNSHSNILSDSQQSYYNTWSSNVLSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW77</accession>
    <name>G3AW77_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112197</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683731.1">
        <property type="nucleotide sequence ID" value="XM_006683668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW77"/>
    <dbReference type="STRING" id="590646.G3AW77"/>
    <dbReference type="GeneID" id="18246397"/>
    <dbReference type="KEGG" id="cten:18246397"/>
    <dbReference type="eggNOG" id="KOG3010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_1_2_1"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="46"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="302" mass="34279" checksum="24BB169CFC42B238" modified="2011-11-16" version="1">MATFSKTGFKTLNYNSFRPRYPPSFYQLLAKYATGSDSPKPIQRTLDIGCGTGIATYDLLNISENVVGLDLSPSMVQTCNDLKAQRCEELGIKDQSRVSFVEGDIDSLPTNEKFDLITAAQCLHWSSDFPKFFKRIHEILKPGGTLAYWYYVDPIFVNDSPEALQKAKKIYFKYAYDDPNLMGPHWEQPGRNVIKNCYVDVNKHIPKEAFTDVTIDSYYPSVDAYVPPSDDKNLVLVKPGVGIKAMEKYFSTYSGYHNLLAVNKDSTFIDDYAKELKEATGWTDDTKLDMVWNTGYTFLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWL1</accession>
    <name>G3AWL1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112281</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWL1"/>
    <dbReference type="STRING" id="590646.G3AWL1"/>
    <dbReference type="GeneID" id="18246445"/>
    <dbReference type="KEGG" id="cten:18246445"/>
    <dbReference type="eggNOG" id="ENOG502QUE5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014054_0_0_1"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="624" mass="66649" checksum="57129FE97B597CC8" modified="2011-11-16" version="1">MSKPVIAPRQVVGRPSPASVASSPSVNENSPSAASPPVSVKLRPPTTTAPFSSVSTPSTSIMTSREWVLPPRPKPGRKPSVDTPASKRKAQNRAAQRAFRERRATRVQELESKLLEVEKERDVKEMGLINTINKMKLENQYLIKSLEQLKAEVHSIKRPSGSGPTPSSAGSSTGIYGATGMVHSGVSAKSPTNLASNSPTASIYSVQQISPAPSASADSPPVLGINFKRYSKASVSIGRTPKIEEHNNEFDCGVCMKDDCICESIGIKEKTHPHSHNHNLEETLSKFKPMQAVSLKRKSTTQEIDFTRKFNKRALPDFKKTVSEQSVSADSKFDESSPVDNCGFCSDDTPCVCREAAKEAARLNESLNHTSNDHDDSDLHNDDDSDDFDDQTLPPIQMSSSIRKISLPVMHPGPSVGIRDITNLTPGAVPTVMTPTIGTPTSSNPTGIPSNAGNNSNSESGCTGNPGACSQCQTDPMSTLFCTTVANKGKESNERGGSRSGSSSSDSVPNSSAYSGTSLSAGSTSNAASPRDLPPLSSSATSMNPSTPLDTTNPSTPTSTMMHMANNGTMFIPCADAYKTLSRHKKFNSVDFSTLVGKLTTRGMQVEVQSVANVLRELDRRVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWL8</accession>
    <name>G3AWL8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_101025</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWL8"/>
    <dbReference type="STRING" id="590646.G3AWL8"/>
    <dbReference type="GeneID" id="18245428"/>
    <dbReference type="KEGG" id="cten:18245428"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018787_1_1_1"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF21">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR REI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="387" mass="45220" checksum="AD5C35C4FC84F766" modified="2011-11-16" version="1">MVYTCNSCNLAFEDATNQRDHMKGDWHRYNLKRRVAQLPPVDEESFNLKVSATSQESNDSEKSNKKAERRRKKEEILEQKRKILETARRAMQQKQDAQLMSGMEELGLEVSDPIFIQEQPKDTLSSEELEEQLYKEKEKNRVDIPPSTCLFCHPKERADFATVDESIEHMFQKHGLYVPEIKYLVDKEGLIRYLGEKIGFGNICLCCNYQGRNVEAVREHMKVKRHMRIPYESEDEKLEISEFYDFSSTYNDFFKAEDLIGENDGDDWEDISGEEGEYNSDEDLPEKDAGAIVQNGFELILPTGKVLGHRSLQRYFKQNLPPERELSEGQGTIVAAEDRHMLNVRDKKEFGTQKLAWRSEQYNAKFYEKKAAKNANNQMHYRDQLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWQ4</accession>
    <name>G3AWQ4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable metalloreductase AIM14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_112306</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573</strain>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Probable cell surface metalloreductase. May be involved in iron or copper homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ferric reductase (FRE) family. AIM14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWQ4"/>
    <dbReference type="GeneID" id="18246461"/>
    <dbReference type="KEGG" id="cten:18246461"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036508_0_0_1"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF198">
        <property type="entry name" value="METALLOREDUCTASE AIM14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00463">
        <property type="entry name" value="AIM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="17">
        <location>
            <begin position="95"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="18">
        <location>
            <begin position="246"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="19">
        <location>
            <begin position="331"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV66836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="475" mass="54683" checksum="537C838DB20DA42F" modified="2011-11-16" version="1">MSRLLQRHEGEHHKDSHGHGHNSSHYANIKWGYILLAGSLVYFAVFLAYERRRPKYSKPFKISTHIALWISATVGLCANLFPNIVENSSTLLKRFGRFSYVLTTVDLLLALRPNLLNYVYLVELHKWMSRYVIVLGIVHSVGFLVRWLVMGQLFKVLRLLNLLGVAIFLMFVVLLVLSIKVYRNKYYNTFYVIHNLTLVCYLGLINYHARPGVTWLTMLNLFLVTVQIVFKFNITRIASTSVKNFGSLTLVTFEKPINYPITTPGSHLVLQLSRNWRQWIFPAHPYTIINNNEYLNLVVTNINRFKFDVEHMYTISFPYSSSLSLMEFEGKNVLMVIGGSGISYAISILNFYKTVKINFRLVWVVRDKRDLALIKEFNLNCQVDLYVTGSVSSGDMASELGEQRDGLLHNIEMDEFEVAEDSETPEIMFARGRPQISDFQVPDLLIACGPDSLIYDAQAFATANNVNFLKEFYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX24</accession>
    <name>G3AX24_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112407</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX24"/>
    <dbReference type="STRING" id="590646.G3AX24"/>
    <dbReference type="eggNOG" id="KOG3502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_1_0_1"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="67" mass="7583" checksum="AFE1B8313B09A641" modified="2011-11-16" version="1">MDTKTPVTLAKVIKVLGRTGSRGGVTQVRVEFLEDTSRTIVRNVKGPVRENDILCLMESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX77</accession>
    <name>G3AX77_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112445</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX77"/>
    <dbReference type="STRING" id="590646.G3AX77"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="152" mass="17329" checksum="5A1E817C506057C6" modified="2011-11-16" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKHKKNKLAVLTYYKVDDDGKVERLRRECPSQTCGAGIFMGNMGDRQYCGKCHTTFKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXB7</accession>
    <name>G3AXB7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pex19 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_117057</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXB7"/>
    <dbReference type="STRING" id="590646.G3AXB7"/>
    <dbReference type="eggNOG" id="KOG3133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043063_1_1_1"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33554" checksum="45A8D2072EB0ED30" modified="2011-11-16" version="1">MSEEHKDTNTKATAVQESTEDDLDDLDELLDDFAGEVLSKPPGSTVLNDANVKEEAEVDEPINDEFKGKLEDLIKELNIQDPETKGQFEQLVKNFEEDTNNESPKDPKDFDSIMKNTMERLKNSGKDIDEQIKNDQSSSNPEDMLTQLLSGLGGGESGDLDMSKLLVDMLEQLSSKEVLYEPIKDLNTKFPDYLKEKKDVITQEEHANYTKQYEITNDIVAIFESSTFSDENKEQRDKVNSLLESLQELGQPPSDLIGDAGDFPGFGGLGAPGVGAEGLNFSDKDLPKDFEKELEEGCKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXD0</accession>
    <name>G3AXD0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112094</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXD0"/>
    <dbReference type="STRING" id="590646.G3AXD0"/>
    <dbReference type="GeneID" id="18246352"/>
    <dbReference type="KEGG" id="cten:18246352"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018787_1_1_1"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="409" mass="46341" checksum="2D15DC29BAD4B39F" modified="2011-11-16" version="1">MSTDITSFVPQMATPSTVSFICNTCGIKFIAADMQRKHMKTEWHRYNLKRRVAQLPPISSDVFAHKILQQQRLAEIRGEVDEFGFSVKPKKVGGKSKTMSEIIRGRVLSTQSNTLNRESSPATSVVSEFSQFSLGDGVSVHEESESNIDTASEFNLTDHSNSDWEFDSTTEEEATESEAESLDDGLTEVMPVSFCFYCGLNNNEVETNVEHMYRKHGLYLPERPFLQDLDGLLTFLSEVIVLDKECLVCGFVGKNLESIRQHMICKGHCKLPYESDAEKNVVAEFYGFEAETAKRVADGEQNDQVIIHTSEHFVAKKLSKTLPSGLEVGHRSMFKYSHPPASLVRNSRESQRSIALVDRRYAPGLSAKILSRQERQVKRLEQRTKNLETRRSSSKQSNVIMHFRDELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXD7</accession>
    <name>G3AXD7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-glycosylation protein EOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_117095</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXD7"/>
    <dbReference type="STRING" id="590646.G3AXD7"/>
    <dbReference type="KEGG" id="cten:90982012"/>
    <dbReference type="eggNOG" id="ENOG502QTWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043059_0_0_1"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02070">
        <property type="entry name" value="NGLYCOSEOS1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38414" checksum="301830E7EE123765" modified="2011-11-16" version="1">MPLFDSLRRRLSHRLESHQIEEDYTPRNSRVQSRSNSIVFNENLRYDVGIYSSPLQTLDQGEAIPSYEASQLMHEQQQGSGNGNGTNVHGTDPLHHLPTSTSNLLNSDPITPNTNSMNVSRSGSVAAGSSTDSSNNSGGTSNKNKNKTLKSLGLKFLNARQHFALACCRDLSLIPCILGLFQSWGRAFFDAEIRNSTSLTQAKLPEHFLTGVWCIVAGYLSYSVLDSLMIRWIVTYSTSAAILRMLSMSTIIVTVEHYLLSSLSADGYKYGLHIWILISCCHTLVYIGQNFVTSNLDLKGKQKARFFDFYNIVVFAVVPVGLASFITMIGLLRSLLIVRLDIENSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXE7</accession>
    <name>G3AXE7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_91520</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in spliceosome maturation and the first step of pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SPP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXE7"/>
    <dbReference type="STRING" id="590646.G3AXE7"/>
    <dbReference type="eggNOG" id="ENOG502S8BR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091434_0_0_1"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="6">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="215" mass="23380" checksum="1AC90DCDF764EB14" modified="2011-11-16" version="1">MSGFSFKLKPKKAESKNKLGFSLGGQKKDVPKKKNAFANESDSEDEENKKTVIESFDPKAEAKANKTESLVIKPSFLSRRIPTKPELPRERAADVIEASGDLDSQARLAVMNGVTISSGPVIETPNPRVGDAEDMTTESYDEVPVEEFGMALLRGMGWNGKSAVTKPQTNTAKRKQGLLLGIGAKALKDEDLAQELLSSKAKFSVPLVKKSLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXL1</accession>
    <name>G3AXL1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112457</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996511">
        <property type="protein sequence ID" value="EGV66322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXL1"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105919_0_0_1"/>
    <dbReference type="OrthoDB" id="4022214at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442429" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="7">
        <location>
            <begin position="11"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="207" mass="22305" checksum="F4D6936DDDA1F972" modified="2011-11-16" version="1" fragment="single">MSWLKYAAIALCAVSTRAAEISLDRIDRDTVSLAIGDYKIDEGVYWSIIDNTLTSFTGGFENDGSFYITTDNRLIGLTVSIINLLKTISNSGDWAFNASRTLTPPSYTLSSLNFQNTGSMWFGGDGSLGVPLMTVQSHTWENDGLIVFSLNKRSTSGEVILGASLELGTGTITNDGTVCLINQVYHQTTAIDGSGCFDIGSDSNVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXS6</accession>
    <name>G3AXS6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_101423</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXS6"/>
    <dbReference type="STRING" id="590646.G3AXS6"/>
    <dbReference type="GeneID" id="18245467"/>
    <dbReference type="KEGG" id="cten:18245467"/>
    <dbReference type="eggNOG" id="KOG2197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004457_0_1_1"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="370"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="722" mass="83965" checksum="D6AC02F8A624EA82" modified="2011-11-16" version="1">MPPKQRTLLSGEVELLYVKSKVYLHPSASKRDNVVGFLSISKGPNSTNSDLLISFTAESQLSKESLKLYQEADLDELDGSKDLKVVSKPVSSVLSGYSYSVPMSYIYSIQLRKPSSGMWYGSVVINTLDGEKLPIIFFHDDESPSTKLRQKKRNQSFETFSESGEVIWGGTEFLAVLHNYCHLVKSTVEPSVYLVNPASDDLRNFAPFKEKPKPGKDSKKKEFQIPDFNKVIANAKWKVLETVATFSAKTKNQVIDIVDEHAPLPIKQLINKPEVQKLGNEFEGARVYLAKWAAQVKEEAEESQKKFHLNEEMYTIINKELGNELLTNEEVSKAGRREAISKSEWDNFFDYSGRLRVTVNEIKDRIFHGGVSPSIRGMVWLFLLEVYPWDSSAEDRTVIRASLETQYHELKAKWSTDEDKRSTEFWKDQKFRIEKDINRTDRHLDLFKNTKRKRISVSSLASNVPPTIRESSPETPDEDDDDEFDVSNIRNPHLFKMREILLTYNEYNENLGYVQGMTDLLSPLYVILQDEVFVFWSFTKFMDRMERNFVRDQSGMKKQMLTLNQLVQFMLPDLFKHLDKCESTDLFFFFRMLLVWYKREFEFDQVLRLWEILLTDYYSSQYHLFFAAGVLSDNERIIIQNLRRFDEVLKYMNDLSNHMNLNNLLIRSELLFLKFRRMIDIINRENLYKSERTIVSPDLLQLLSRDIVVEKEGPRPVGAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXU5</accession>
    <name>G3AXU5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_133107</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXU5"/>
    <dbReference type="STRING" id="590646.G3AXU5"/>
    <dbReference type="GeneID" id="18249670"/>
    <dbReference type="KEGG" id="cten:18249670"/>
    <dbReference type="eggNOG" id="ENOG502S6DV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767254_0_0_1"/>
    <dbReference type="OrthoDB" id="5358702at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="391" mass="44437" checksum="9C3825B598DDB446" modified="2011-11-16" version="1">MMDTKMMRSRSVQSRTTMSLCKQVYETLTSFPGKPKVVQFIPQIDMNSLFMVHEEVGAIDIGITKQNYLSAFKQAHGLWHSQRELFTQALTEVAQSDLYSIFYVTVTYLFTTNDHHQVFKLHERILAELYRRDAHVLEAEFEIITTLLSSRLSKINKNSLLWNLLRKLTVMMNFDGGRFNVLLARVLQSCRLHYANYYGNNYLRWLIGVSIAVGDGTKVEAIRTQLTEVCHESLADVSLWTNLRVLLYADSRTIQAAVYQHVRAVDEVNRKFGVTVASPVVADSPTTTTHNPQFALDQLHWLLSVECCNITPYASVVPLEQQAPFQPVLVAALAAQNKRAGSFPPDHPALDHHRHFIAVLQHLTVSASPHPDQVAVENSQRNRIRTTLHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY24</accession>
    <name>G3AY24_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Catalase</fullName>
            <ecNumber evidence="12">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_112614</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 13">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="12"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY24"/>
    <dbReference type="STRING" id="590646.G3AY24"/>
    <dbReference type="GeneID" id="18246604"/>
    <dbReference type="KEGG" id="cten:18246604"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="6"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV65754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="485" mass="54761" checksum="0ED63F289A4CCE65" modified="2011-11-16" version="1">MAPTFTNSNGCPITPDAFATQRVGKHGPLLLQDFNLIDSLSHFDRERIPERVVHAKGSGAYGYFEVTDDITDVCGAGFLDTVGKKTKTFTRFSTVGGEAGSPDSARDPRGFATKLYTEEGNLDLVYNNTPVFFIRDPSKFPHFIHTQKRNPQTHLKDANMFWDYLVSNPESVHQVSILFSDRGTPASYREMNGYSGHTYKWSNKKGEWFYVQVHFISDQGIKNLTNEEAGKLAGSNPDFAQEDLFKNIKAGNFPSWTCYIQTMTQEQAKQAPFSVFDLTKVWSHKDYPMRRFGKLVLNENPKNYFAEVEQAAFAPSHTVPYMEPSADPVLQSRLFSYNDTHRHRLGVNYTQIPVNCPITGVFNPHMRDGAMTVNGNLGSHPNYLASDQPVEFKQFSLQEDQEVWEGAACPFHWVAGDAEFEQASKLYEVLGRYPNQQRNLAHNVAVHVAAADAPIQDRVFEYFSKVSPKLGQAIQKETLELSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYE5</accession>
    <name>G3AYE5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_112695</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8 9">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684772.1">
        <property type="nucleotide sequence ID" value="XM_006684709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYE5"/>
    <dbReference type="STRING" id="590646.G3AYE5"/>
    <dbReference type="GeneID" id="18246641"/>
    <dbReference type="KEGG" id="cten:18246641"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018310_0_1_1"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000118">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9 10" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="203"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="322"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="74"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV66198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="436" mass="48889" checksum="288DE1B1C914075C" modified="2011-11-16" version="1">MNNQKLVTDELNQLQKEIIAKNPVDVLQFCANYFNSKLELQRSYLWQQQARAKAAGLNLFPNIDNVSLMSNSHVNGRQPSFKSPFNANENDPHQLFKDDYSANHSTNENHLPELDPNDPSPAFTDPNDPNAPLPADLEESRDKPRPLTNTKIPIKFNVNRRTSVSAEALNPDKFKTDSWKPPTNNLTESQKTELGKTLHSNFLFQKLDSTSKKTVLSALTKKTYKKGDEIITQGDEGDYFYIIESGTVEFYVDNIERGTSKEGSSFGELALMHNSPRAATVIAASDDVTCWALDRLTFRRILLEGTFNKRLMYENFLKEVKILSGLSTQEISKLADALTTEIYHQGDKIVTEGESGENFYFIESGNCEVFKSDQGRVTELSKGDYFGEVALLNNLPRQATVQAVDTVIVATLDKSGFQRLLGPAVDVLKSNDPTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ15</accession>
    <name>G3AZ15_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_118989</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ15"/>
    <dbReference type="eggNOG" id="KOG0973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004372_3_0_1"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF1">
        <property type="entry name" value="PROTEIN HIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="679"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="466"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV65980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="973" mass="108876" checksum="55C21F90D7CD1619" modified="2011-11-16" version="1">MRVLVYPHTLHGGEVHTLGINNSNTHLLSAGKDGTISVWNVSDFVKFNKVDYSEIKANLENHTFQQNYTYHTSPVKTVVWSPVDDDAFISGDANGTIYMNNVKKNEPAKVYPFRQNEQASAIVDLTWSVDGRLICWSTVDGKVHILDLTRRTYQELTSLVKAEKLVPQRSLAFDPTNKYLITVGDDTVIYIYQFQYIPHSKNYQFKILHHITRLINEPNIHVNYSRISWSPGGEFVSIPSSSKNKTTLITILSKLSGWSNSFSLVGHGTECEVVRFSPQVFEKLEPEDSDLGFSNVIATSGSDQTLALWNTSKRSPIFVLQDAVKGAIVDICWERNGRSLFLASMDGNITVVTFEEKELGIPLTDEKIKELTVPDPIDPKSFNTKIEQSSGSRRTNNTVDILEGKDAISADVHDNKPTEEQIPKSNEVNGKQDLVTENIIASFTPDVIPPPDLTNANTVDDILDSAMEGSSSKDNKNSSNGTLVNKLEVSKQKVTTKNGKKRIQPVLVSGNKDASNNNSIQNTIEVKIGSKTGSVPKHMMELDKPSFNVSDEFYKQVKRQKVNDDTTKKQKRELEPVKFIGSVVVNPNTTFSKTRLATPKVRLGFSISSAIENDESFVLDVKNGSGNDARPSRITYFRKDKQIWTDFIPKFIHLVSEGSSFWAVSTNDGTVLTYSHTSGKRLLPPIVLGSPLSFLESHGKFLMAVTNIGELYVWDIDAKKLHLNSPSGVNVLLENNTKYLDEGLSRSDKITLCSITSVGIPLITLSNGSGYLFNIDLGAWQTITESWWAFGSHYWNSLSGENGNRPQSANLFGNEEDGESIMSLLENKTNEEIIRGSRTGRGKFFNKISKNMMMKEGFENLENTISVSHLENRILCCEILGEKKDFHEFFISYVKRICELGLKAKVFEICSQLLGPEAAEEDEDEDEIIETTWDPKICGLDKHELLKEVILNCSQLRDSQRILTYFAQKIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ68</accession>
    <name>G3AZ68_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="4 7">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_92371</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="4 7"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ68"/>
    <dbReference type="STRING" id="590646.G3AZ68"/>
    <dbReference type="GeneID" id="18250193"/>
    <dbReference type="KEGG" id="cten:18250193"/>
    <dbReference type="eggNOG" id="KOG2949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="306" mass="33215" checksum="6285FBA91790219D" modified="2011-11-16" version="1">MFRSIRSLSSTNRVYSSFKHATTRNTIADIYSMYHQKVPISMVTSHDFITAKFAEQAQIDINLIGDSLAMVALGYDDTNEVSFDEFLYHVRSVSRGNSKSLLIADLPFGSYEISADQALETSIKMVKSGRVQGIKLEGGLEVAPVVSKIVAAGIPVIGHVGLTPQRHNTLSGFKLQGATTESAMNIYKDCLALQKAGAFAVVLECIPNKLASLITENLNIPTIGIGAGPGCSGHVLVMADMLGMNGPSNAPKSKFVKEYANLYETAVEGLQQYKADLISQSYPDPEVHGYKMKKEVLAQVKQYIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZF4</accession>
    <name>G3AZF4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112943</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684655.1">
        <property type="nucleotide sequence ID" value="XM_006684592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZF4"/>
    <dbReference type="STRING" id="590646.G3AZF4"/>
    <dbReference type="GeneID" id="18246747"/>
    <dbReference type="KEGG" id="cten:18246747"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="486" mass="53717" checksum="474417A3E89A5040" modified="2011-11-16" version="1">MATTSSTPQTSVSPSPSFAEKSTAPVSYVFQAKVDTRLPEVVGGKGSRFTVKDPATHETREILDGMTGAAVGALGWGDEDVVDFITKAAKNTTYQFPAVIGNRPAEELAEYYIKRSPPGTFAAATWTTSGSESNELALKTIRQYWLERGKPQKIKNLSRYTSYHGYSLGCLSLGNNNRAFPFKDILHPDTQFVKLPEFYPYHYQKEGETLEEYSERLLKQYEDIILKEDPETIASMTVETISGTSIGTPVPTKTYMYGLRKLCTKYDILFHLDEVMCGTGRINSGGLNCWENFLPLNEGPDLQTVGKTLGSGYVTIAGLLVSSKIRDEYVKGSNVIVGSSTYASNAFNCYVALEIQKKIEELNLTKNMFEQGNYLGAQLKEKLASSKIAGEVRGLGGFWTVEIVKNKATREPFARSLSIYNMTKNACFENGLSVVGSNDCIRDVGGDFIMFAPHFTLTKEEADEMVKITVESIKQVEEQLETSGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZL0</accession>
    <name>G3AZL0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112482</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZL0"/>
    <dbReference type="STRING" id="590646.G3AZL0"/>
    <dbReference type="GeneID" id="18246538"/>
    <dbReference type="KEGG" id="cten:18246538"/>
    <dbReference type="eggNOG" id="KOG0183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="251" mass="27694" checksum="E9A8D407A0093D2C" modified="2011-11-16" version="1">MSGYDSALSIFSPDGHVFQVEYASEAVKRGTCAVGVKGKECVVLGCEKRTTLKLQDPRITPSKICKIDKHALLAFAGLNADARILVDKARVEAQSHRLTLEDAVTLEYLTKYIAGVQQKYTQSGGVRPFGIATIIAGFDANDETPRLFQTEPSGVYNAWKAHAIGRSAKTVKEFLEKNYEENMTDEETLKLTIKSLLEVVQTGAKNIEVSVLKSGDRIQQLTVEEIKKYVDEIEAEKAADAEKKKPRARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZR3</accession>
    <name>G3AZR3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Increased recombination centers protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_133531</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in gross chromosomal rearrangements (GCRs) and telomere healing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IRC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZR3"/>
    <dbReference type="STRING" id="590646.G3AZR3"/>
    <dbReference type="eggNOG" id="ENOG502SAXB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064540_0_0_1"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0160">Chromosomal rearrangement</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="279" mass="31918" checksum="0C10F433D1B7BB74" modified="2011-11-16" version="1">MIPNHILVLGPPNSGKLRVADLMSGGGSCDVPNESHSGLIVKGELKTKYYSSHVNILIDEYPSIRTDSNKKAHDHKQLLEWYDEFKKEECKELRDVLDGFIFTINLDTEPLQLVTKSLEVISMLKELLTDESEDDFFCLIVGVSEEIIDYLEVEDSCINNGLEFVYFNEAGTNEYKDRIGKDRIMEVLETHKWRSVDTSSSEKYTENKMRKVNGSLMESLLGNDNNEDNETDNYENLEEVELTGVLEKLKLAKAEASTMSHEEKELYVQKVIDDLIDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZT6</accession>
    <name>G3AZT6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_119349</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZT6"/>
    <dbReference type="STRING" id="590646.G3AZT6"/>
    <dbReference type="GeneID" id="18248694"/>
    <dbReference type="KEGG" id="cten:18248694"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002572_1_0_1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1017"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1045"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1071"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="12">
        <location>
            <begin position="356"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1166" mass="132418" checksum="442AEFC17DA412A5" modified="2011-11-16" version="1">MSFRNSTNSKNYQEFDPEAGELGRKRSLVRPERSRIDQSHPRYHYTQVTNQQSDHLKVQPSSTGLDPQVSNHDSTYNPRNSFHSYRTLNSKYPEEQEGIPLMDYGDENKSNTASPHKGGTEVFGLNDEVEYSPHKKDVIKKNSLKRRSMTNHDNRESDGTSMWRIYCYIITFWAPSPLLYLFGLKSKERQFAWREKIALISVILYIGTFVAYLTFGFTKTVCSKTAIRTRINEVNSGYLIINGRSFDLTKSQHPGVAGIDAGSNILYPPTNAGGKDASLLFQNVNGNCKGLIKPRDNCTIPTKDTDEVAWYMPCKLLEQDGSSQPNFTTEYYDGWACHTSSDARNAYYNLKVTGDVYFTWGDINNSSRNLVVYSGNVLDLDLINWIQSDDLEYPTLFDRLRDEEAYKGHDISLVLSNSDERHAARCLTEIIKVGTIDSDTIGCIASQVVLIVSLVFILSVVVAKFLMACYFKWFISLHQGATDLNSKSMESSNKSMENWVDDDGALQRNLVVIPSKMRADYKTNRQSVFKRMSLTPNEMSQYYINSENLSKNFKYTTMGTQNYLMANKNPQKTNASKRQSTMFLNETFNSSTDLLNRQSTVNPFDIDDFSTMQGLSPDIIHPDVVPQPPVEYQPYGFPLAHTMCLVTCYSEDDHEIRITLDSVAVTNYPNSHKLIVVICDGLVKGSGNEETTPDIVLGMMTDFVVQPEEVQPYSYVAVAQGSKRHNMAKVYGGFYKYDDSTVPPENQQRVPIITIVKCGTPEEANLPKPGNRGKRDTQVVLMSFLQKVMFDERMTGLEFQMLQTIWQITGLMPEMYEITLMVDADTKVHPDSLTHMVAEMVKDPAIMGLCGETKIANKNQSWVTLIQVFEYYISHHQSKAFESVFGGVTCLPGCFCMYRIKSPKGSDGFWVPILSNPDIVERYSDNITKSLHRKNLLLLGEDRYLSSLMLRTFPKRKQIFVPKAVCRTVVPNKFSVLLSQRRRWINSTVHNLMELVLVRDLCGTFCFSMNFSIFIELVGTVVLPAAICFTIYVIVYAATTTPTPVLSLVLLALIFGLPGLLIVITVSSFQYLVYFVIYLFALPIWNFVLPTYSFWKFDDFSWGETRQVGSEDKGSHGDLEGVFDSSHIVMKRWREFERDRKNEGLTMPSATWNPSNTNLLNDSFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZZ0</accession>
    <name>G3AZZ0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113013</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684959.1">
        <property type="nucleotide sequence ID" value="XM_006684896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZZ0"/>
    <dbReference type="GeneID" id="18246783"/>
    <dbReference type="KEGG" id="cten:18246783"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000907">
        <property type="term" value="F:sulfonate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044273">
        <property type="term" value="P:sulfur compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="84"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="387" mass="43792" checksum="A969EAD0E3CAC798" modified="2011-11-16" version="1">MATRPNGGNYDIHFHEGIDEVLPDGTLVVNKVNRDASNHPEFLPTWNPSQKLPPLKFFKHQEPGTRADPSFPNLFPKDVKVVNKKVTPKLGTEITGVQLSELNDKGKDELALFVAQRGIVVFREQDFATKGPEFAVKYGSYFGRLHIHPTSGAPKEHPELHITYRRADPGEFERAFSQNTNAVGWHTDVSYELQPPGTTFFSVLEGPEAGGDTIFADVVEAYKRLSPEFQKRLEGLHVLHTSEDQASSSRGNGGIERRKPISSIHPLIRVHPATKEKAIYLNRAFSRRIVELKVEESAFLMEFLYKHIEQSHDLQMRATWQPNTVVVWDNRVVQHSAIIDWDTPVSRHAFRITPQAERPVADLKDLNKEEYDVGDVAEALKNVLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B027</accession>
    <name>G3B027_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_129585</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B027"/>
    <dbReference type="STRING" id="590646.G3B027"/>
    <dbReference type="GeneID" id="18249392"/>
    <dbReference type="KEGG" id="cten:18249392"/>
    <dbReference type="eggNOG" id="KOG0486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028430_0_0_1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="523" mass="59432" checksum="9E700A5ABF0BE903" modified="2011-11-16" version="1">MPRAPSPCSFMNTFFISKSPDEWSFLPLLIPQLAPPLPHSLKVGVDTYMTGKRTRASGEVLDYLLHEFELNHNPSPDQRREISDKTNMSEKAVRIWFQNRRAKLRKSERKGRSAHSGSIDSSRSNSVGTAERKQYSRFSINEKYCFIDCTSLSVGSWQRVRSGYYNEQLLKEGLFNLSPFTLNKVMLDFDLLVIVSKKNSEINYFFSSMSDTSRILFRIFYPIANILSCSLLDNNIEKECNELRVTLSHRPKFSVNFYNGVNSSSNQWSICDDFSEGQQVSSAHRDGGSYIPHVLVGTKDSICFLNDFILEQNQQHQGNYMMNDTNSSTGLEGGIEGGYEDEDRVNSQDQSKSNSDNDNMNDMNDMNGINDEFQFSNTHLGPIWNETNELKANGLSPLGQFDGHPVPERKPDLHANFHHNEIFSANTPDFVTASQTPNIISSLSGTTPLEGDRDMEQDTAPEPNRINTSPFQNINNQETFDAMPTDETFDFPLVNEYEVSEHSNIDSPVDTNIERFIDYNNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0J9</accession>
    <name>G3B0J9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_113171</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0J9"/>
    <dbReference type="STRING" id="590646.G3B0J9"/>
    <dbReference type="GeneID" id="18246840"/>
    <dbReference type="KEGG" id="cten:18246840"/>
    <dbReference type="eggNOG" id="KOG2874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040185_0_2_1"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="120"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="271"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="338" mass="39670" checksum="66E45B380B72EF50" modified="2011-11-16" version="1">MVSTHNRDKPWDTPDIDKWHQDEFQPEHNASGQPFTEESNFMTLFPKYREQYLRSIWNDVTKALDKHHIACQLDLVEGSMTVRTTGKTFDPAIILKARDLIKLLARSVPFPQAVKVLQDDTACEVIKIGNVVTNKDRFVKRRQRLVGPNGNTLKALELLTKCYILVQGNTVSVMGPYSGLKTVRRVVEDCMKNVHPIYHIKELMIKQELSKKPELANEDWSRFLPKFKKQNVQRKKAPKREKKVYTPFPPQQQPRKIDMQIESGEYFLRKSEKKQKQMDEKKEKQEEALSAKQQQRQQDYEAPEEESYENPLKKRKHHGEESKKKKSKKDKKDKKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0R0</accession>
    <name>G3B0R0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_129707</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0R0"/>
    <dbReference type="STRING" id="590646.G3B0R0"/>
    <dbReference type="eggNOG" id="ENOG502QSMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008599_2_1_1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="227"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="540" mass="61716" checksum="695955B9BC15883B" modified="2011-11-16" version="1">MFSTLILHKPSSDNSNDFVDLQIAQLLPSSIDPNYRPKRKQTRSEIRNENYSWDERKQGELESSTTDGMATTESNCYLGAASSAALINLIGGGFFMNEGKVTSPVSTSSSNLLNHGVISRSKLEHYINQYFETYHISYPMVHKPMFMAQFNEIVSPPNGWESLLYIVAAIGSFMSAVSPEENDDLILFEIAKSKLSIDVLETGNLTLVQTLTLMSNYLQKRDKPNSGYNYLGLAVRMALGLGLHKQISDTNESLLDQETKRRIWWCLYIFDCGQTITYGRPLGIPCAGIDSRLPLNILDTELTGFTISLPKEQDSSTDYTSLRLQSLFHIFTNSIYERIITDPFPSSQELLKWDEMYIQRWKNQIPEYFKEDATVPPKYRLAHAVIEWRVRNLRIIMYRTFLLRNVVVNSNGIEQDYDSKAGEICLQECSATVKSMYLFWSAKTTYNRMDAWYSLFFLIPAVVMPLVCLRNNPLDANAEAWRSRILHFIEFLGAGYLTQGVESQELSFPLNGTDESPFSQLIQLHSMLWPVSFDIEQQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B194</accession>
    <name>G3B194_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldedh-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_103899</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B194"/>
    <dbReference type="STRING" id="590646.G3B194"/>
    <dbReference type="GeneID" id="18245663"/>
    <dbReference type="KEGG" id="cten:18245663"/>
    <dbReference type="eggNOG" id="KOG2454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="81"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="613" mass="67851" checksum="77AF65A4163D4AFE" modified="2011-11-16" version="1">MIDIDLIFNGTQWQYQISTTFFICVILPLLYYCYKRYVSKSPNSYNKIEAPIKLNVSIPDEAKPHWKGKRLYSPTLRIPDEPNKIQSYCPATSQSLGVFPTTSKEEMDQQIKAAKVAQKQWAKSSFSLRRKLLRTLNRYILDHQEDIARVACRDSGKTKLDASMGEIMVTLEKINWIIANGEKTLRPSQRPGPSNLLIGMMKSGEVRYEPMGVVSAIVSWNYPFHNLMGPLIAALFTGNAIVIKCSEQVIWSSQWFVLLVRTILKSLNIPEDLVQLCCCFPEDAEHFTSHPGLDHITFIGSKPVAHKVVESASKQLTPCVVELGGKDAVVVLDDVKDLNALASVIMRGTFQSGGQNCIGVERVICLPKAYETLVEILSKRVGQLRLGSDIDQLDEIDMGAMISDNRFERFQELIEDAVSKGAKLIHGGKPYQHPNYPQGHYFEPTLLIDVDQTMKIFSEEVFGPCLTMVKASDLDTAVDLANATEYGLGNSIFGGNFGVCSQVADRLESGNVAINDFATFYVAQLPFGGIKKSGYGKFGGEEGLTGLCVTKSVVMDKPFFRMLGVATAIPPPLDYPIADGTKAWGFVRALNSAGYDNKIWTVIQSIKKLAQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1F4</accession>
    <name>G3B1F4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_121196</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1F4"/>
    <dbReference type="STRING" id="590646.G3B1F4"/>
    <dbReference type="eggNOG" id="KOG0575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_46_2_1"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000647">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000005">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="75"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="471"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="569"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="656" mass="75308" checksum="07C520CD1328555E" modified="2011-11-16" version="1">MSVRTKPLQPLNSGQMNARNASNVTPIKLKKSTKDFYEHQQQQQQQQQKKKKKEKLSALCKTPPSVVRTRNGRDYRRGLFLGEGGFARCFQMKDSNGQIYAAKTVAKASIKNEKTKTKLLSEIKIHKSLKHSNIVNFIDCFEDDVNVYILLEICPNQSLMELLKARKRLTEPEVRLFMVQIIGAVKYLHERRVIHRDLKLGNIFFDPNMNLKIGDFGLASVLESFDSRKFTICGTPNYIAPEVLGGKANGGHSFEVDIWAIGIMMYALLIGKPPFQAKDVQIIYERIKKSEYSFPIDKPISAEAKVLIQDLLDVNPLRRPTIDEILSYDWFKGAFPDKTQETTLTKEPEGLTMISKNQSAMNFKNMKVNCGIYTPKTKNPVEILKTDLQSEESQMVLPRSLSPNDTKFKYKEVDPTMLTKKRFQFNSNFSNSVLDLDKTCHTTYVNMCKLETLVDSKLDTMTLPSCENPTLISKWVDYSNKYGFSYQLNNNDIGVLFNDGNTILKMTNNEKFLELLLHEQEGWTCIENSIYNAPSKCKKQLEIVDFFAKYMNSNLSKVSDVEERKEIVFLRRYTRTSDFIMFEMTNGSFQFNFKDHHKLVVSKNGLAITHISPTRITQTHPLILILKQGNFPSVSIPDCMEKIEIIKQAIREKAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1M3</accession>
    <name>G3B1M3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_113250</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1M3"/>
    <dbReference type="STRING" id="590646.G3B1M3"/>
    <dbReference type="GeneID" id="18246866"/>
    <dbReference type="KEGG" id="cten:18246866"/>
    <dbReference type="eggNOG" id="KOG0647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038526_1_0_1"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="370" mass="40803" checksum="E86527BE766953EE" modified="2011-11-16" version="1">MSSFLGRSTNTNPTATTSSATGQELVNDISINNPPEDSVSDLSFSSQQDLLAAASWDKKVRIYEIDSNSGNNQGRALYEHDAPVLSCVFSPDGARVASGGADKQVKLFDIASQQAQQIGVHDAPVRAVRFVECGPTNTPVVVSGSWDKTLKYWDMRSPQPVSTVNLPERCYSMDASQKLLVVGCADRHVCVIDLNNPQQIFKTSMSPLKWQTRVVSCYPQGNGYAIGSIEGRCAFSYVDEAEQSKHGFSFRCHRKTPNSTGTSALRTNTESHIYSVNSIKFHPVYGTFSTAGSDGTFCFWDKDARQRLKSFPELNHSITSSAFNKNGSIFAYAISYDWSQGHQGNRPDYPTQIKLHPTNDSEVKQKKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1P8</accession>
    <name>G3B1P8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_113268</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685804.1">
        <property type="nucleotide sequence ID" value="XM_006685741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1P8"/>
    <dbReference type="STRING" id="590646.G3B1P8"/>
    <dbReference type="GeneID" id="18246872"/>
    <dbReference type="KEGG" id="cten:18246872"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_3_1_1"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="145"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="347" mass="37486" checksum="54DFBC73F14D6EFF" modified="2011-11-16" version="1">MSPKNLNIAVIGTGIFANDAHLPTFNKIPYLTPIACYNRTKAKAETFAERANIDKSKVYDSLEKAFEDKEVDFVDALLPVQFNLDVVKLAVKHNKPLALEKPVAANLTQAAEIVKIAESTDLPIGILENWAFYNAVGALQDQLPKIGDVTAFTYKSTGPWNTNNKYLATTWRQKPEHVGGFLSDGGVHQMTLLTEVLGSVETISANTVQLREESGDQDTLFSTIKLQSGAIGTFVYGSAFGASEKKLEFAIYGKNGSLVYTLAPAEGKPSLVIRIGKDGNSGESQTIAVEEGDSYEKEFVNFADAVTANDKSVIAISPRKAFHHLAIVDAALKSSKDNGASVTIQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Q5</accession>
    <name>G3B1Q5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_113272</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 13"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Q5"/>
    <dbReference type="STRING" id="590646.G3B1Q5"/>
    <dbReference type="GeneID" id="18246875"/>
    <dbReference type="KEGG" id="cten:18246875"/>
    <dbReference type="eggNOG" id="KOG1355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_3_2_1"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="301"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="333"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="415"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="427" mass="47459" checksum="2C9B58536ED82B24" modified="2011-11-16" version="1">MLDVVLGSQWGDEGKGKLVDILCDDIDVCARCQGGNNAGHTIVVDGVKYDFHLLPSGLVNPKCLNLIGSGVVVHVPSLFEELENLEKKGLFCRDRLFISSRCHLVFDFHQRTDKLKEAELSATKKSIGTTGKGIGPTYSTKASRSGIRVHHLVSEEPGAWDEFKVRYQRLVESRYKRYGDFDYDVESELKKYEGYRELLKPFVVDAVDFVHKAIADDKKILVEGANALMLDLDYGTYPYVTSSATGIGGVLTGLGVPPRTINNVYGVVKAYTTRVGEGPFPTEQLNEVGETLQDVGAEFGVTTGRKRRCGWLDLVVLKYSNLINGYTALNITKLDVLDKFKDIKVGVSYSYKGKTLSSFPEDLTLLGKVEVEYVTLPGWETDITKVKNYDDLPENAKKYLDYIETFVGVPVKWVGTGPARDSMLKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1R9</accession>
    <name>G3B1R9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphodiest-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_120063</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685321.1">
        <property type="nucleotide sequence ID" value="XM_006685258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1R9"/>
    <dbReference type="STRING" id="590646.G3B1R9"/>
    <dbReference type="GeneID" id="18248750"/>
    <dbReference type="KEGG" id="cten:18248750"/>
    <dbReference type="eggNOG" id="KOG2645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017594_4_0_1"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="709" mass="80425" checksum="16FCB0751ABAD5CA" modified="2011-11-16" version="1">MSINYSVPHRVDIPVTNLDDDSDDDILFNEQIRSRSSSPLPRGDSFSDNTINDLDYEFSTKCTSPFLDRIKGLFGRNNYRHVESYELRDTLDLNDFNLRDDEENLNTRSQTIKRKHFKGLVFFLTTTVVFMTLYFLKGSAGTPAVALKTTYSNTTHSFYPTTIVISLDGFHPHYVSAKLTPSLHDMMMNEYGAPYMIPSFPSSTFPNHWTLVTGLYPSEHGIVGNTFYDPKLKKQFVNTNPKEGGLDPDFWRGGEPIWETAYKQGVNSAVHMWPGSEVPGVGIGNGPLHVDRYNGSEHLSSKVDRVMAWLDVDHISERPELILTYVPTIDSYGHQFGISGPKMRRALASVDDFVNMMRKEITFRSLDDIVNLVIVSDHGMAPTSNNRLLFLDDIIDLSKIQHIDGWPLFGLRPYKEYSVDEIIEELNTNINKLDDSVKNNFDIHTVETLPKEWDFGGDLNDHKFNYRLAPIWIVPKVGYSITTHQQMDEKHNDYTPKGVHGYNNTELLMRAIFLGSGPYFRAKLTGENKRVQPFRNTEVYNLICESLSLKPSPNNGTMDNGYIISAIDERNLLPDEWSEPLSYPNLDYHVDSIVQNATYDLLWRQQVADKSDTHTQSNPKQSLSVEESTLAADLDVSIPKPFDIVSTATKINQITTPTEGPSPGGFLDNLLDQISEVGEGIEDSFEEVGDHLKDTWKDLESFIDGDKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1W1</accession>
    <name>G3B1W1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein RCR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113313</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1W1"/>
    <dbReference type="eggNOG" id="ENOG502S2K8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078289_1_1_1"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21550" checksum="7F55766C2D9942E3" modified="2011-11-16" version="1">MAVLIISNSMSPTVSLTKRYGFDSSNGARWAFFGIFLAVILLVVVGTIRVNKKRSSSGLQPIYGTRWMTPPSYVQSQTQYNQPSTRNHDSYVPQTYVPTYTERANDQDMGYYDATGEFHPNPNAKVSTPYTPKVPGVSQPSEAHRRATSNSDGIALSEIPAVENATDSTQHRRQAGEEEDLYNFTRPSGPPPATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B206</accession>
    <name>G3B206_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113340</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B206"/>
    <dbReference type="HOGENOM" id="CLU_2454498_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="89" mass="9957" checksum="3342FF9B459200F0" modified="2011-11-16" version="1">MSTDSSNIHTQDIQVFNYSEVNFTTMVTAISMLLAVNQLIAELERLQRNRRMINTGGPARTGSGSGYEQGDMDVSMLMRLLMLLASYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B261</accession>
    <name>G3B261_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phospholipase D/nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_113382</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B261"/>
    <dbReference type="STRING" id="590646.G3B261"/>
    <dbReference type="eggNOG" id="KOG2031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1566596_0_0_1"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="171" mass="19715" checksum="E12B336D9EE906F2" modified="2011-11-16" version="1" fragment="single">MSQEAKIGYSVGRSIHFDYTSRLNRSNYEQNIKPYLCKWNNGHEYTGRERNPAHVKLYMCDNGDDFKSLKWLYMGSHNLSKQAWGGGSGFGSWQNINEYQVSSYELGILITPENDKDTLKPVFCSDFSSEKYPVRMPLYLPPTRYSPTDMPWSKNISYGDVKDSLGCSYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2E2</accession>
    <name>G3B2E2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_113441</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2E2"/>
    <dbReference type="STRING" id="590646.G3B2E2"/>
    <dbReference type="MEROPS" id="T01.012"/>
    <dbReference type="GeneID" id="18246959"/>
    <dbReference type="KEGG" id="cten:18246959"/>
    <dbReference type="eggNOG" id="KOG0175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_1_1"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="280" mass="30690" checksum="632C33EF5F437C2D" modified="2011-11-16" version="1">MNSIATQFTNANRNGVLEEINGTYGSGPATLELAPTMQLPPISQPTAFLRAHTDDAANPDCKIKLAHGTTTLAFRYKGGIVIAVDSRASQGNFTASQTVHKVIRINPFLLGTMAGGAADCQYWETWLGTQCRLHELREKERISVAAASKLLGNLVYNYKGMGLSMGTMICGYTQKEGPALFYVDSDGTRLKGDMFCVGSGQTFAYGVLDSEYKWDMPEEEALYLGKRSILAAAHRDAYSGGSVNLYHIDINGWKYHGNFDVGELFWEVKEKEQSFNNVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2J9</accession>
    <name>G3B2J9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_113482</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2J9"/>
    <dbReference type="STRING" id="590646.G3B2J9"/>
    <dbReference type="eggNOG" id="KOG0838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_5_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="121"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="397" mass="44891" checksum="4D48883E7504F975" modified="2011-11-16" version="1">MLKQSVRYVSNVRRSLGASKAQSRDKRTTIDRYLPQDPPKKEKEWEKRGVSKDEFFTKKYSFMSDWGKQKLEHKISREQRFKPQRSDSYRDSRSQTSNDYRGSRYDDFEKHSILDNALLEYVYGRHAVLSVLKAKKRQSYEKLVYTEGKTPITDILSMCKKYGVQTELAASKQQLDFLTNKAVHNGVALATRKLELPTLAKLGPHDAETGTYNLDIWNELYNAQTTIHKQVQRSSEESRNPLALYLDEITDPQNVGAIIRSAYFFGVDFIVTPSHNTARLGPAAAKAAAGALDLMDIYQVENGLKFIRDVKESPWALVTTEVKESTKTITHSQLSDILVDAPVLLVLGSEGSGVRTNIKNLSDFYVRLSKNRTDSDAVVDSLNVSSAASVLISSFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2K2</accession>
    <name>G3B2K2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_129910</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685504.1">
        <property type="nucleotide sequence ID" value="XM_006685441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2K2"/>
    <dbReference type="STRING" id="590646.G3B2K2"/>
    <dbReference type="GeneID" id="18249410"/>
    <dbReference type="KEGG" id="cten:18249410"/>
    <dbReference type="eggNOG" id="KOG1843">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015320_2_0_1"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="360"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="419" mass="44734" checksum="3EE5283FABE89AF4" modified="2011-11-16" version="1">MGINNPIPRSLKSESKKAAKVLASFIKPNQVVGPDQIIPPQVLKNAKGLAIITVLKAGFLFSGRAGSGVIVARLPDGSWSPPSAIITAGAGVGGQIGAELTDFVFILNTKSAVDSFAQFGSVTLGANVSVAAGPLGRNAEGAGTASLKGAAAIFAYSKTKGLFAGVSLEGSAIVERREANRKFYGEDCKARHILSGRVEAPPACDSLMRVLESRAFNNRLPSDDDDYDDDYYDDIPDNFSDSTTASPSSRRRAGTASSRRRYSDEYSDEYSDEDRDYGRSGSSRGGARRQPSNSLRTNSKTNSRWEDDIYDTGRSTNGRSRGNSEVDRLGSRLGDSRISNNGPSRPPTSSKPNFGGAPKPTASQAIALYSFKGEQPGDLAFKKGDVFDIVKKTDTTDDWWTGRNNGVTGIFPANYVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2M7</accession>
    <name>G3B2M7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113500</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2M7"/>
    <dbReference type="HOGENOM" id="CLU_2996353_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="57" mass="6276" checksum="4E00FF330A0E1BCF" modified="2011-11-16" version="1">MAKTVHLAPTRGFTIVLLLILSRPTFGELKLKVLTRKRQSVFPVGIGVKFVPVSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2S4</accession>
    <name>G3B2S4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_120693</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2S4"/>
    <dbReference type="STRING" id="590646.G3B2S4"/>
    <dbReference type="eggNOG" id="KOG2328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010510_0_1_1"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="695" mass="78879" checksum="DBDDE1AF3E42A631" modified="2011-11-16" version="1">MSEILPKKRGRDGTAKRYHSNVQDLANMGRVISGRVVSKSKRVLSNRGDLFDEDSNNSFAEDAINFDQNRNTIMSNFEEWIKLSTDNKITTKNSWQFALIDYFHDLNVIKDGDDINFQRASATLDGCVKIYSSRVESVATETGKLLSGLANKKNQDDGDDGVEDEDNDLDPTADGDTRRARKINRVLESTLVPFETIRVKKLDQELSIDPLFKKALAEFDEGGAKSLLLNTLSIDKTGRVIFDATTTGAKADEDESESSEKLAMIAKSMNFSKIESMLFKNDKTLDDLAICPSMDQLKVVLNDIDQAKSILTDVNNKFMENSQVLDDKSVTKIEEGGGFDFGDYNDNNFNEDNFGINDNDNDDYDDDYDRQKQQIKQEDDEEYELGPGNQILDQDLMAYFDETMKSNWRGPEHWKVSAYKKSKNIADLKPEESKQLAETQKPSRTKKDSTIVDFFSTDEVDDDDLFAPPNSLSYLKKKDKEEDTKLPQDIQYNSARLVTLFLKPSSNILYYPKVRKASNSNPESQFTDENYFAHQYNQQERMASFHQAQLEEINHDYDEDDGDVFGGIDFNDVLEEGEGDEALDNKNLLIGGRKARPEYVNFSRISKRVDIKLLKENLWKGIQIEAAPAEQESEAKPDTKNFGELIENIGKMYSPEEKKDLSTSFCFICLLHLANEHGLSVRGNETHDDLSITGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B358</accession>
    <name>G3B358_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114119</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B358"/>
    <dbReference type="STRING" id="590646.G3B358"/>
    <dbReference type="GeneID" id="18247272"/>
    <dbReference type="KEGG" id="cten:18247272"/>
    <dbReference type="eggNOG" id="ENOG502RXHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067894_0_0_1"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012677792" description="Protein BIG1" evidence="10">
        <location>
            <begin position="16"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="304" mass="35112" checksum="3A26C5E99F4D082D" modified="2011-11-16" version="1">MNLLTVFVFVHLARCFDVVPLLVASHRLVPGLKNELAATNTGHRHNGAEVTNMLKKLVTQCSSDEYIILDIPGVNYRDLNDAAASNWPFLTRYLSMSSTVVGLSFVNDYIDLDYLQQYISTTCEAEVMVANVEDDNSINYIDAKPRVINIRFDELPTDEDERRARIVANDDFIRRIIRKLPSPHYTIVLTSSKRSQIHPVPPVAMDENPSMFGLFNTITNSPHRQAEVEFNDMYKSVEPVWYQDRNTNHRYLENRKKDVVQFLDYELWTKNEQLVMTLLVMMVTVGMIRVKQLFGWVFGKQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3K7</accession>
    <name>G3B3K7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 19">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_114240</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573</strain>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 19"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3K7"/>
    <dbReference type="STRING" id="590646.G3B3K7"/>
    <dbReference type="GeneID" id="18247329"/>
    <dbReference type="KEGG" id="cten:18247329"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_0_1"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 19 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV64415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="416" mass="44529" checksum="3B31AAAB089FB751" modified="2011-11-16" version="1">MSLSNKLSVKDLDVTNKRVFIRVDFNVPLDGKKITNNQRIVAALPTIQYVLENKPKAIVLASHLGRPNGEKADKYSLAPIAEELSSLLKKPVKFLSDSVGPDVEAAINGASNGEVFLLENLRFHIEEEGSKKVDGEKIKASKEDVAKFRQQLTALADVYVNDAFGTAHRAHSSMVGLDLPQKAAGFLMAKELEYFAKALENPTRPFLAILGGAKVSDKIQLIDNLLDKVDLLIVGGGMAFTFKKVLDNMPIGDSLFDEAGAKNVEHLVAKAKKNGVELVLPVDFVTADKFDKDANTATATEEEGIPDHWMGLDCGPKSKELFEATVAKAKTIVWNGPPGVFEFEKFASGTKSLLDAAVKSAEAGNTVIIGGGDTATVAKKYGVVDKLSHVSTGGGASLELLEGKELPGVTAISDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3P9</accession>
    <name>G3B3P9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_93728</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3P9"/>
    <dbReference type="STRING" id="590646.G3B3P9"/>
    <dbReference type="GeneID" id="18250317"/>
    <dbReference type="KEGG" id="cten:18250317"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773851_0_0_1"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="358" mass="41558" checksum="1473B42B90C7319D" modified="2011-11-16" version="1">MGPDNTRHSTTTTPADTTTTDTTHLVHNKNGLRKFIETSTAVVVDSNCKVIGRDVSHLKLTKFNKIGGHSIIYKYDKYIIKEIMEEHLMYEKIMANYPQLSQYLPLYLGTVKLQLNHEVKDYIVLEDLTNELSQPFVVDLKMGTRQYGIHSPPEKVKSQKLKCKNSTSLSLGIRLCGLQIINKKGNFELYDKYYGRQLNATGFLNNLVRFLNNKSRYTLLIKCLKVVEHLKSISSMIESLDYFRLYGSSILIIYDNMDDFNVIIKLIDFSKSFFYSEQEFGNLNLEATKDYGYLKGIFNLIESFKVIFNAASGMVIENDNERVLMETIERNKHDYMDSWNKKLEFPTFRYQYDDLTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3R4</accession>
    <name>G3B3R4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_122566</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3R4"/>
    <dbReference type="STRING" id="590646.G3B3R4"/>
    <dbReference type="eggNOG" id="KOG4530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_2_1_1"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="194" mass="21904" checksum="6FE96E8F3E5F9E68" modified="2011-11-16" version="1">MAKFTVGLLVGSPRLKNNSGGIASWIHYQLKALHPDYQVKKFTPTTPLNLVSTPINSVSPRNIKDGSYEDAIIRTWSKEVSSCNAIIFVTPVYNHSYTGQLKIMIDHLFHEFFGKPVILIVQGPTSASLGLDHLRALVNKYQMNVVDELSMKIPYEYVSSPKRVASEFDGTYTNDPFLKEWELKLQEAIEKLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3U0</accession>
    <name>G3B3U0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113769</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3U0"/>
    <dbReference type="STRING" id="590646.G3B3U0"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001382">
        <property type="entry name" value="Transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="225" mass="24473" checksum="E243EA6D119EBB75" modified="2011-11-16" version="1">MFSKPIYNNIKYPQPQYNRQSASITRLPSFSEVITQIPLPTEFPLSKPAGVSVTPVSVTPAISITPGIGARSLSPASPYPVSYYYSYGYGAPTVAAATAPSVSPARSVSPKTLLPTPPPTMTAVTSTSTTTSTATSPKAIGSPVVIHKRKHVCKICSRSFTTSGHLARHNRIHTGERKHVCPWSNCDARFARQDNCMQHYKTHTNGKKRKNNLSFKNRSINSKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3V2</accession>
    <name>G3B3V2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yippee domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113777</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686054.1">
        <property type="nucleotide sequence ID" value="XM_006685991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3V2"/>
    <dbReference type="STRING" id="590646.G3B3V2"/>
    <dbReference type="GeneID" id="18247117"/>
    <dbReference type="KEGG" id="cten:18247117"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043857_3_0_1"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="4">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="181" mass="20962" checksum="2840246F8E2929B4" modified="2011-11-16" version="1">MGLQYTNFFEEEDYESSDTQIIVCAECSCHLCLSSLVISDSFSSISGQAYFVDKLINISADKEIEETQMRTGLYWVKKIRCHQCMNVLGWSYVKSASSRESYKVGKFVIEDAYIRFIDNNSSTKNLIELTKQNYRRRLSSNSTLVEEDEFKFGDLKCLNRLRLQNVKELENESDADVLVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3V6</accession>
    <name>G3B3V6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Shr3 amino acid permease chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113782</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3V6"/>
    <dbReference type="STRING" id="590646.G3B3V6"/>
    <dbReference type="GeneID" id="18247120"/>
    <dbReference type="KEGG" id="cten:18247120"/>
    <dbReference type="eggNOG" id="ENOG502RXJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="228" mass="25596" checksum="0877603624CC751D" modified="2011-11-16" version="1">MKLMTYKELLPVGTGLIIFATGFGLGAVYSNLPYDYATLWSSPADSTAAFQASFDHYLRWANVPARVHYMLHFVFVIGLVGCLIKIFKPTEDTKYFEYGTMGMLLLSIVIYLSNLRTGINSCFHNQWGEVPMETGINVIAASQFFIVVLLVGVLVLQGGLYYAEWYDKQLKIEFYEQNPDYKEVNGQPTKVDELTAAGNEEGEAVAITSGADVKKDKKDKKDKKKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B454</accession>
    <name>G3B454_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_113822</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686558.1">
        <property type="nucleotide sequence ID" value="XM_006686495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B454"/>
    <dbReference type="STRING" id="590646.G3B454"/>
    <dbReference type="GeneID" id="18247132"/>
    <dbReference type="KEGG" id="cten:18247132"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="283" mass="30610" checksum="8E81BD501453E867" modified="2011-11-16" version="1">MQTTYQSFIKGPEEDNTVPVKSKTFSTNIKDRFSLKGKVTVVTGGLGGIGRAICIGYAQMGGDVAIMDYARDGGEFSAQLQSQWGIRSKSYRLDATASDAVKAAVESVIGDFGTIDVFVANAGLPWYKGTVISESATVEDWHKMMDINLNSIFYCAKYVGKHFEQQQKGSFVITASMSAHIVNIPQYKAAYNVSKAGAMHLAKSLAVEWAGFARCNSVSPGYTDTILSSPVPTEDRAKWWGLTPMGREAHPEELVGAYVYLASDASSFTTGTDIRVDGGYTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Z5</accession>
    <name>G3B4Z5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_114060</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Z5"/>
    <dbReference type="STRING" id="590646.G3B4Z5"/>
    <dbReference type="GeneID" id="18247240"/>
    <dbReference type="KEGG" id="cten:18247240"/>
    <dbReference type="eggNOG" id="KOG1498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="235"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="449" mass="52292" checksum="95F2857C0DB20EEA" modified="2011-11-16" version="1">MSREDPLKAEKDLSSILDEQFPEIDKLDYKSAIDRYLILEKQTRQSSDLASSKRVLSAIVNKLIDNNDWDYLNELTPILSKKHGQLKSSIQSFIAQIIENLDKLDESKQSELDTKIKVIETIRTVGDKKIYIEVERAIVSKQLSDIYLNRLNDLDKAVEILCDLQVETYSLMSFQTKIEYILQQMKLVLTKKDFSQAKILSRKILLKTLKGFDKAEEYKVVYLNYLIEINENDHDYVSIVQNSLKLIESEVVQNSEEFKNILVSVIYYIILSPFDNLQSDLISKIKVNSTFSKNVDAKTFKLLEIFTTEELIHWSNIETLYSNEFKSSKIFQNPTNYKNLQKRIIEHNLRIINNYYNFIKIDRLSYLLQLSNDEAEKYVSDLVNAGMISAKINRPKGMIKFDKVGKTTDSVNTLLNDWCYDVEKLLDEIDQIGHLINKEEMMHGIKQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B535</accession>
    <name>G3B535_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, F0 complex, subunit J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114447</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B535"/>
    <dbReference type="STRING" id="590646.G3B535"/>
    <dbReference type="eggNOG" id="ENOG502SC94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174950_0_0_1"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="60" mass="6760" checksum="9DFE4F2E7E2749AB" modified="2011-11-16" version="1">MLPKFATPMLKHFWPFGVGAVVTYGLVYKGSVLSMNSDEFINDPRHPRFASGGKFIELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B596</accession>
    <name>G3B596_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_135001</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686958.1">
        <property type="nucleotide sequence ID" value="XM_006686895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B596"/>
    <dbReference type="GeneID" id="18249830"/>
    <dbReference type="KEGG" id="cten:18249830"/>
    <dbReference type="eggNOG" id="KOG2816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017517_2_0_1"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="646"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="73621" checksum="8C49B0DFBD8F296A" modified="2011-11-16" version="1">MSRSEQHPLLDKRRPSVKFRDVTVNSEADLEHTFNDIYDAIADDNLLDDEELDEDAIWLREQRTLNKTLHWLKRPSLFILGINVFVFAFADLTAESTRQLIYFKLACNSLLQESGSGSCDAAQAEVMVSHMKACFGVAASVIALLVMTKVGSLSDQYGRKYFMVAVVLDIFLTRALKYYLLSRYDHLMFKWLVFSEALASITGGMMTFMNLVNCYIADIADYHERSYFFGVGISFFYAGVSLGPVSSSFLMEFTKKFRAARPQVIVADATINAVEPYEWDPLRLELVAFAVCSVLAIFMLPESRPEKSRRRSRSLSVISRTTVGAEDQKPLSLHTITSKVVGSITTYFSPLKLLWIPEEFKPVNYTDGRFYRERMAVILLTTCDCCLTCMSTGSGQVFMLYGILKFSWSAGTLGYVLSITFAAKAFTLIILAPFLNHFVYHKVFHFKVMKRQLDMLDFVNITVGLSVDALTLFWYPFINTTPVFLGVLGLSSFSALASPSLNSAIVKYYPDSQTGALFSAIYLVKNICNITVPVLMLTIYNYSITDWNNPGILFQIMAACLLMLVGFMFIVKRLLNLSGTSSAEVLTRTSSFSRSRSNSVAHSRSGSISSVNVTIPAAGASSDYFQSADSGSRADSEGSPQKLANPMSNTLKKNSSFSGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5C5</accession>
    <name>G3B5C5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Snare-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114503</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687372.1">
        <property type="nucleotide sequence ID" value="XM_006687309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5C5"/>
    <dbReference type="STRING" id="590646.G3B5C5"/>
    <dbReference type="GeneID" id="18247452"/>
    <dbReference type="KEGG" id="cten:18247452"/>
    <dbReference type="eggNOG" id="ENOG502SG8J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097630_0_0_1"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="170" mass="19400" checksum="649B2D44E27923F0" modified="2011-11-16" version="1">MAEFEDKRICFISFISRDDKPLYIQSFDLDTKQGDTINANNFLKYNFLSHMALDIITSPASISIREQQQEADVRNGAVLLVVYDDVSVYGYESNTGLKIIIGFNNQTHLNQEESKMVTLRTLFLSVHKAYVKTICNPFLEIDSSGDIEGMLQNEVFDKSIKKIVNDWNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5G9</accession>
    <name>G3B5G9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_135054</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5G9"/>
    <dbReference type="STRING" id="590646.G3B5G9"/>
    <dbReference type="GeneID" id="18249838"/>
    <dbReference type="KEGG" id="cten:18249838"/>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008978_5_0_1"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="453"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV63221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="673" mass="75407" checksum="B7C745D7182BF693" modified="2011-11-16" version="1">MGVSGLHPQLKEISIPVSLEKYRGKTLAVDTYSWLHKSTISCAQELCLNQPTQKYVSYIIKKINMLRHFGVEPYMVFDGASLPTKAATAKERKERREEAQAKADEYMKKGNKKLAWKEFMKAAAVTSQMSKSVMVELDRMNVKYVVAPYEADPQMVYLEKKGYVDGIISEDSDLLIFGCRTLITKLNDFGECIEISKSNFSKVTTISGLDSFTPQQLRLVAMLSGCDYTKGVPGVGLKTAFNLVKKYNQIDRVLMALRAEGKKLPPEGFEVELIKADLAFQYQKVFNPKDQTLETLNEYPEPFDFDMELVEQCCGVTFDAEIHVGISKGKLHPNTHEVLISREQNITSLKSKSFTSEPKISTVARTKSVGSTSSRRMVAPRGRIDSFFSVQKSTKITTTDTTSDQQKLQIEAKAEVHTEQVSPDHKRVRTLLTPKENPPKLVGTFSKFFKSPAGGIPTPRSTFDADITGDSEISDVSSPFRYTKSTSDKVDTNNVLGNLTDDDIDTQTQSDHKMEENRDDSQPPESPSSKISKQPAVGDFDLDDDEDDIEESPVKSLLPSGIHFNNNRDEIKQLLRDTFSFRPGSKEKFQVPKALQKLSAFENASTISIASAESSHSDSSFDLNSEEFHEVQKHAEVFTNIDMNKSFESISSKRTTKSKLEIKNSSLSRFAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Q2</accession>
    <name>G3B5Q2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF788-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_106021</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Q2"/>
    <dbReference type="STRING" id="590646.G3B5Q2"/>
    <dbReference type="eggNOG" id="KOG3269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094308_1_1_1"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20286" checksum="EFAE6355B67812CC" modified="2011-11-16" version="1">MASSSSKKIAQTNKQKLYELHSISATVVLLCAAIVWFFKRPSSIKPFLFFQLPLIGCQYVIESSCRPKYKYDSVGDYDKLVSSGHDMNQSGLTEYMTDVIYFTWILDITVVALGSNKVWYLLLIIPGYAAFKLSGFIKGFFPSKQQQPEQASLDPQKPEGKSKRQQKLEKNGRRKILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6B2</accession>
    <name>G3B6B2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_123667</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6B2"/>
    <dbReference type="STRING" id="590646.G3B6B2"/>
    <dbReference type="eggNOG" id="ENOG502QV98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569850_0_0_1"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54132" checksum="027D3603524224BF" modified="2011-11-16" version="1">MNVLSSNGQTNPQNHETNPPMSMASTYSNHMKSHRSNSGSMKSRPVSPSPQSPMMSPKPISLFRAENSKPMTFTADEISMDDGLEPKSPSEVDESKSEKHPSSPNDLFGNTFVKPGASLTSIFIFGGFILVDNGTSKAFEATNDFLRIDLVCDGDFVSTNMDPEAIIYKVKLEDPSNTPNASGYCASTLIEHNLEEEENCQWNTIVRPWSPGSIFDDEASSSTSMQTSNSRHPSKLVKITTPEEFYEKKALLIQGGCNHNNETFSDMYLFKFASRQWEKLDTFCFNHFDNNIQPYDDDPSENLTKDKQIDKPDLIEAELRASHHTALYYNKLGREFVFFVGGFTNHYLRNYDPKPYHSDKFDVSRLARVRTTTTNQEICRLLVYNTKTQTWGFYKYYYDIRKNVSQQSFELLQHLRELVNANMYHHGAGVSLDGKSITICHGLVTPVTEKKADFEALDSQFPGPSMILGAHIQITFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6D4</accession>
    <name>G3B6D4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_123710</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 13"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6D4"/>
    <dbReference type="STRING" id="590646.G3B6D4"/>
    <dbReference type="GeneID" id="18248973"/>
    <dbReference type="KEGG" id="cten:18248973"/>
    <dbReference type="eggNOG" id="KOG4519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022059_1_0_1"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="14">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="451" mass="49590" checksum="E5DC96111A491C6C" modified="2011-11-16" version="1">MVSAFSSPGKALIAGGYLVLDPVYLSYVTALSARMHSVVRCNRDVAYRRISVSSPQFGGKWIYHIDQDITEINDNNNPFLAAAVEMAMKYTQPSHPFDVDITIFSDAGFHSQQETVVHGSTNGTKRFLYHQKPIADVAKTGLGSSACLTTVVMAAIMSQLGPASANNTNIIHNLAQIAHCRAQGKIGSGFDVATAVYGSIQYQRFVPGLIAPHVQGEAATGLVPLVDSEWDFTHNPCTLPPHVRLLMGDVAGGSETPRMVSKVLQWRKDHPEQSAKVYADLNTANRQFIAALSRLRDLSMSDLSSYMEGIDFFASHSVATLDDYLEDHPDRRIEEEVPYRYFYELMESIKMIREHMKSLTAYTGADIEPMSQTLLLDECRLLPGCFGGVVPGAGGYDAIALLVIDRAIDPIVEQTKNKREFAHVTWLGLHEEANGLVAENPRDYEGLPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6P2</accession>
    <name>G3B6P2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_130546</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6P2"/>
    <dbReference type="SMR" id="G3B6P2"/>
    <dbReference type="STRING" id="590646.G3B6P2"/>
    <dbReference type="GeneID" id="18249453"/>
    <dbReference type="KEGG" id="cten:18249453"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_1"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="381" mass="42605" checksum="4A7B1DCEEC633A1A" modified="2011-11-16" version="1">MAIRAYADTGEITVPLIHPLLLKRAQTMQQEFSQLESKIAGGSYDAETNRKFSTVSGILEHLDRYNKDIATIEGLQEIQDPELMDDVQQELESILPNLMRSTTILQNKLLPPIKHADLPCILELRPGVGGSEAALFTADLANMYLNFANQMRWKHQVLSKHESSSGFVNEFILSVDEPGAYNRLRHESGIHRVQRIPATESKGRIHTSTAAVVVLPKFSDGDEKSLAADERSFKPGEVRVDTMRAGGKGGQHVNTTDSAVRLVHLPTGIMVMQQDERSQPRNKAKAFSILRARLAALERDKEVAEQKKLRTDQVSSTDRSDKIRTYNVPQNRVTDHRCNYSVHDVDGCMQGYRLGEIIDKVEEGEFEDRLQELIGHVGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6P7</accession>
    <name>G3B6P7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_93762</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6P7"/>
    <dbReference type="STRING" id="590646.G3B6P7"/>
    <dbReference type="GeneID" id="18250323"/>
    <dbReference type="KEGG" id="cten:18250323"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014456_2_0_1"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="147"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="677" mass="76410" checksum="F19BB721D1201F8B" modified="2011-11-16" version="1">MPPMSTDKIDPDTPADTGPTPETTDQLHGAGALTLPEDQFADEDNNPFDHTSLSSMINDKNHVHTTNLHGDGGPDRVKNHQVDVVDAAGDASAPVFASPEESVLLYTNPKSNGDGSTDTEATTTGSIQINTESRVMRLLRPSSNMKVQITEANNSSEGMSNSSKKYIVYTIKLINEDNKEEVQTRRRYSDFESLREILTKVFPLVIIPPIPPKNYINFSILNNIVTSKGSNIVSPKQKESTNNYSYINSTHLNSNKLIEHRKRLLTSFLNNCLNIRQIRNLEFFSKFLDPNTNWQDEINLISNQLPKDIYHSNPENGLKTDAVYASLPHFTTNINMGFLNTISENSKKLGKSTGKLINGSGGGDPENSVPTTASEDSNSLSPKDSNENDLNSDSIETVNTSHLDDINRKIMDNFIGLANDYTELGTVFNSFSLLLADAPIIRTKSQEQGEDKDVGKLNIILDKMGQVFDRSYITINALISDLETKFSEPLGEEVQYSTTLRFIQKFQRRKDRQKKMLDSELKEKKATLQGLLKVEEETATIENAINSDPVSKQRRYQLDQNAPNNSYASRFKFPNMNSIKKITQYVSDIMDQNPQETRKHRISDLKTKINTLEKCQDIMLGDISYIADELNKNFKNFHKKQLKVIYDILLCYNGFLVNWAKKNLDIWEEIREEVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6S8</accession>
    <name>G3B6S8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Iron transport multicopper oxidase FET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_130568</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6S8"/>
    <dbReference type="STRING" id="590646.G3B6S8"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000025">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0410">Iron transport</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="18">
        <location>
            <begin position="84"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="207"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="414"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV63010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="76364" checksum="68EEAE18D63DF33B" modified="2011-11-16" version="1">MQWNGCYIPNIHQLPPLKSPQNWSAYQIHAERPIILCKNKTKNNYQINQCDKNGIPGQISPLAKINGKSSFGYCKTHYWNYTANYVDANPDGVFTRRALTLNGEWPPPVLRVGKGDRVVFNLTNGLEDQNTTMHFHGLFQPGSAQMDGPEMVTQCPIPPGAHFVYNFTVGDQVGTFWYHSHTAGQLGDGLRGVFVIEDDEYPFDFDEEITLTIADWYHKSSDELSKSFMSLYNPTGAEPIPQNFLVNDTTNFTWNIEPNKTYFVRIVNVGAFVSQYLYMDDHEFEIVEVDGIYVNPNTTDMLYITVAQRYGVLIRTKSNTDKNYAFMSAVDQDLLDKIPKDLVLNQTSVLVYDENNDTPDQYYVDAWDFFDDFYLSPYNNETLYEDPDLTVTVDVVMANLGNGVNYAFFNNISYVTPKVPTLLTLLSAGDDATNALIYGTNTHTYVLQKDDIVDIVVNNQDTGKHPFHLHGHVFQVISRGEGVPDTSSPVAFDADSMSEFPEYPVLRDVVYVNPQSYMVLRFKADHPGVWFFHCHIEWHLRQGLALQFVEAPEDILNDSRQTLTDNHKDVCDKVGVSWKGNAADNDKDFTDLTNQNVQVKPLPAGFTARGIVALVFSCISAFLGLVAIAIYGVADIKNIEQKVVEDMGLDISEFKEDGVEGEVKSAVNKQCAYFLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6W9</accession>
    <name>G3B6W9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114343</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6W9"/>
    <dbReference type="STRING" id="590646.G3B6W9"/>
    <dbReference type="GeneID" id="18247385"/>
    <dbReference type="KEGG" id="cten:18247385"/>
    <dbReference type="eggNOG" id="KOG0877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_2_1"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="74"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="252" mass="27243" checksum="ACB47A92BE12FE3C" modified="2011-11-16" version="1">MSTEQQAPRRNFGRGGKKGGPRRGPRRDEEKGWTPVTKLGRLVKAGKISSMEEIYLHSLPVKEFQVIDQLLPELKDEVMKIRSVQKQTRAGQRTRMKAVVIIGDSNGHVGLGIKTAKEVASAIKAAIVIAKLSIIPIRRGYWGTNLGAPHSLTAKTSGKCGSITVRLIPAPRGKGIVASPVVKKLMQLAGVEDVYTTSSGSTRTTENTLKAAFAALGNTYGFLTPNLWKEAALPASPLEVYADEAAAVKRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3B793</accession>
    <name>G3B793_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115058</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B793"/>
    <dbReference type="HOGENOM" id="CLU_1713014_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="153" mass="16531" checksum="158A3CA723FF92CD" modified="2011-11-16" version="1">MLGSAQSQVSFVSPSTIPRSASIGHLMNAFRMLAQSHASTKPRSSDTTNQRTRPLQSPPIQGATASPQAPPCESQTSVTICSSQFHKRLRRTKHITLSGTNLRCINLSGTMTRDCPVPVVAPEHRTAEFPLAHVVFFDKIKDGVNCAQASGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7W3</accession>
    <name>G3B7W3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115130</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7W3"/>
    <dbReference type="STRING" id="590646.G3B7W3"/>
    <dbReference type="GeneID" id="18247731"/>
    <dbReference type="KEGG" id="cten:18247731"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017542_3_0_1"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000030">
        <property type="entry name" value="FHA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="137"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="347" mass="38460" checksum="B128B204F92B39F6" modified="2011-11-16" version="1">MANSPTIANFGTYNTNNNDEPTTPVGTSADTAEDELESPSSPVAQADDNRTDHETTDMDVTMVQPREPEPATEAVGGASGEPSTDAVTTTQEEVGASAKDKDGFYSLRLTPLIDHSSSSSGLYFAPIIRRTRSSQVIRIGRYTEKNKAAAHAPQGSDAPIVFKSKVVSRTHALFQCNEDGQWFVKDCKSSSGTFLNHIRLSPASQESSLMPLIDGDIIQLGMDYRGGTEEVYRCVKMRCEFNKSWQRKVNQFNLEIHQKLKNLSLQQGQPEADDNPLSNALKSDELSECAICLLKLEPCQALFISPCSHSWHYKCIRPIIIKSYPQFYCPNCRSMCDLETDIEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B849</accession>
    <name>G3B849_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_131703</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B849"/>
    <dbReference type="HOGENOM" id="CLU_3111864_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="51" mass="6279" checksum="EAD405361B34305A" modified="2011-11-16" version="1" fragment="single">MQQQQAAQQQAKALQQTLIQKFPLYFQRLRQLQVARQRQQQQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8D0</accession>
    <name>G3B8D0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_107642</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate. The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688539.1">
        <property type="nucleotide sequence ID" value="XM_006688476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8D0"/>
    <dbReference type="GeneID" id="18245970"/>
    <dbReference type="KEGG" id="cten:18245970"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_2_1"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="194"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV62369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="287" mass="31837" checksum="62F51DA6ECC177E7" modified="2011-11-16" version="1">MSEKPLPFIYQFISGAVAGVSEILVMYPLDVVKTRQQLDSTNAYKGTIQSIKKIVAEEGFSRLYKGISAPILMEAPKRATKFAANDEWGKFYKRVFDVPVMNQSLAVLTGATAGATESFVVVPFELIKIRLQDKTTKFNGMADVTKDIIKNHGVLGLYKGLESTLWRHIWWNAGYFGLIFQVRGLMPKPKTSTEKTLIDLTCGSIGGTFGTIMNTPFDVVKSRIQAGTTTKYVWTYPSLVTVAKEEGFGALYKGFIPKVLRLGPGGGILLVVFTTCMDFFRGIHYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8M0</accession>
    <name>G3B8M0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_108648</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8M0"/>
    <dbReference type="STRING" id="590646.G3B8M0"/>
    <dbReference type="GeneID" id="18246049"/>
    <dbReference type="KEGG" id="cten:18246049"/>
    <dbReference type="eggNOG" id="KOG2445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_1_1_1"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000578">
        <property type="entry name" value="Nucleoporin seh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38630" checksum="8BF4A70C49830789" modified="2011-11-16" version="1">MKPFITGHEELVHDIKYDFYGRHIATVSSDQHIKVFDLHSATNSWVLNDSWKAHDSSIVKVTWAHPEFSSSKIIASCSYDRTVKIWQEQPDELQGSGRRWMKLSTLAIESYGPIYDAVFAPNHLGFKLGCVGSDGIFRIYESLDPSDLSNWTLTTEIPILSSQLPAKNLQSSFSIEWCPAKFSNSEKFIVIALDQGFVYSSFADNKSDEADGDDDSIKYKKIGNLPEHNGLIRSVSWAPSMGRGYHLIATGCKDGYVRIFKAVEKNDQELKIETIATLNDHNGEVWRVNWNMTGTILSSAGDDGKVRLWKCNYRNEWKCMSVINTSNRDPNRVTEEDLETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8P7</accession>
    <name>G3B8P7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">CANTEDRAFT_99410</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688576.1">
        <property type="nucleotide sequence ID" value="XM_006688513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8P7"/>
    <dbReference type="STRING" id="590646.G3B8P7"/>
    <dbReference type="GeneID" id="18250853"/>
    <dbReference type="KEGG" id="cten:18250853"/>
    <dbReference type="eggNOG" id="KOG2840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_2_1"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000188">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="375" mass="42382" checksum="7A6243DBCDC3BF5B" modified="2011-11-16" version="1">MTVEQKKDKKLKVTQLCELCHGRKAVMKRPKNLQKLCKECFFLVFETEIHNTITDAKLFYKGETVALGASGGKDSTVLASVMKTLNERYDYGLHLVLLSIDEGIKGYRDDSLATVKRNQAQYEMPLEIVSYKELYDWTMDEIVACSGMRNSCTYCGVLRRQALDRGAAKLGINHVLTGHNADDMAETVLMNVLRGDSKRLDKSCTIKTESADSPIKRSKPFKYTYQKEIVLYAHYKKLDYFSTECTYAPESFRGTTRELLKALESIRPSCIMDLIYSGEHFELRKKQVTTTYKNNKKKLPEQEVNPDGSVSLKKTPAPGEARKCDKCGYLSSNKICKACFLLGGLEANRAKVTLDNNTYIDGAAKLTKTLEHLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8R8</accession>
    <name>G3B8R8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-glucan synthesis-associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_99423</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8R8"/>
    <dbReference type="STRING" id="590646.G3B8R8"/>
    <dbReference type="eggNOG" id="ENOG502QR13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010811_4_3_1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="250"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="642" mass="71213" checksum="1D93283C89E1A0F7" modified="2011-11-16" version="1">MVDPLTAPQPASNYNGYYLNNSNNNTTSNLLANTSTANTPDSLNAINNNLLNNPNYANKNSTNIQVPSEYDRYPSINGSRVVSSTSLSSTFFANAGQAGGAASNLNSKSDTGSSVSNRSASNPFLNSADFSPFGGYPASSFPLHIDEKEPDDYLHNPDPIADAAYDKNRFIHDLRALDKRSLGGLLTFIGLFIAAMAIFVVLPVVTFTGVAHHYTPETYEILTHYSYPIMASIRTALVDPDTPEDALTKKTRSGDTWPLVFSDEFNAEGRTFYEGDDQFFYAPDFHYAATTDLEWYDPDACTTANGTLVLRMDAFKNHNLLYRSGMIHSWNKMCFTQGLIEISAKLPHYGNISGLWPGLWTMGNLGRAGYMASTEGVWPYTYDSCDSGITANQSSLDGISYLPGQKLNVCTCKGEDHPNRGTGRGAPEIDLIEGEVSTEVLVGIASQSMQIAPYDIWYYPNYDFVEIYNLSVTSMNSYTGGPYQQAVSAVTTLNNSWYERGGGEHHFQHYGYEYLNDDTDGYCTWYVGDEPTFTVYANALAPNGNIGWRRISKEPMSIVMNFGLSNNWAYINWPSLIFPSELRIDYVRVYQPSDQKSVTCEPDDYPTQDYINDHLNAYQNVNLTSWTDAGYTFPKNSLVNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Z3</accession>
    <name>G3B8Z3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_131298</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Z3"/>
    <dbReference type="STRING" id="590646.G3B8Z3"/>
    <dbReference type="GeneID" id="18249510"/>
    <dbReference type="KEGG" id="cten:18249510"/>
    <dbReference type="eggNOG" id="ENOG502QVTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442787_0_0_1"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="5">
        <location>
            <begin position="387"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="608" mass="69607" checksum="24D7A2AA252CCF34" modified="2011-11-16" version="1">MSVQPVPINVYTSSTSTINGNVNQMNLIGNGHMGATLMDRIVMSLKSNVASEVEWALASTYQQSFVAPDTIDFEKNEYLGKQLIKYFMVPFRLIQDGKADEISNSTVNLSLDALLSIRNSIQDITNQQWLSQIYEFKQDLADVLKLLVEWIYKDGPGFSLGRYKDQFVEYLFHTIDILDTLTCYYINNPKTDELFNLMLFISTNSSDKYLIIGSLNCLTHLLFTKADTISDNENKEFNNQNNAKSGDESLVPLYDNCIDNFTEEHLEHFLNYLLLNDPKLNVSVLDFIKQYLNSGASDKNQSLKESKFNRLSTLLQINSSKKNLHTLLKQLPVLLTTDVMLNEPITEHKIEEHLAKRSNHSSVPSEPPLLSSNLYDIISKFPEPMRSSVWLRCCYEPIFNDSYDDDTPSEGVIGEVTQISLWKAYEKQFEPIWKNKLAEFPELLPAVDFIKNVTNAFPNSEAMVVMLKNVEPPKKKFIIRGIQPRQFAVDIDVANYEALKKKVVVDKRDINEQLPIGSIDTAKFQQSLESLNSKILFSSTGLKLNKINLLAKDILDYIISQFQQFPNADELVNIFRLYNRSWLLQVVYSNPVLVEIDLVGHEYIKYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9A5</accession>
    <name>G3B9A5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115299</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688020.1">
        <property type="nucleotide sequence ID" value="XM_006687957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9A5"/>
    <dbReference type="GeneID" id="18247812"/>
    <dbReference type="KEGG" id="cten:18247812"/>
    <dbReference type="eggNOG" id="ENOG502RZDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033734_1_0_1"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="312" mass="34595" checksum="B03249924F2385BD" modified="2011-11-16" version="1">MSFEAFQLDKNTCEKYQGASVSNFVFSILITLGIFLSYVPQYHRIYAKRTSEGLSTKFLLLGSCSSIFTFTNIILISSTARSCCRAGALSTFNCINSQLNLVQIGLQCICAIMILVLVLVLTRDSIKQDKAEYRENAKVGKFVMAHFLASIVQIIVAFLSNDGVLVTIANLNGLMSTTLTVIKYVPQIYTTYRLKHPGTLSVGMMCIQTPGGALFTATLFFTKGSHWSSWISYFVAFILQGILLSMCLYFEYFRQGGLNADTLERLQVEQIMETNMREEENDAFDVGNVQSLAKMHTPASDEPTGDTSPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9R0</accession>
    <name>G3B9R0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115405</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688887.1">
        <property type="nucleotide sequence ID" value="XM_006688824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9R0"/>
    <dbReference type="STRING" id="590646.G3B9R0"/>
    <dbReference type="GeneID" id="18247853"/>
    <dbReference type="KEGG" id="cten:18247853"/>
    <dbReference type="eggNOG" id="KOG3290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048953_0_1_1"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="304" mass="34496" checksum="8975A90D51ADCC8E" modified="2011-11-16" version="1">MTFTGLTPEQLETFDREGMLCIPDFLNRDEISTLMKRSHELLEDFDVTTHPKTQFKTGEESHIGDQYFFDSADKISFFFDVDAFDENGNLAFSKEMAVNKIGHGLHIHEKEFHKITFDQKVKEVARSLKFVDPRVLQSMVIFKHPVKDASNPRDNEVPPHNDGTFLFTKPHTAVGFWFALEDCTAENGCLSYNPGTHKTHPIKSRFVKLNGGDDGCGFIPVEHGVKEIPPDRPEDYQLVKCKAGSLILIHDAVLHKSEKNKSSASRFAYAFHIIDGTSEYDNLNWLQVPPGKEGGTEFSRLFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA40</accession>
    <name>G3BA40_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_125440</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA40"/>
    <dbReference type="STRING" id="590646.G3BA40"/>
    <dbReference type="GeneID" id="18249104"/>
    <dbReference type="KEGG" id="cten:18249104"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_1_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="8">
        <location>
            <begin position="60"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="347"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="445"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="541" mass="63198" checksum="3FC18F65A752ABF4" modified="2011-11-16" version="1">MSSSKRQKLEPQLPQFHNKYYPSEITDKQVAQRYLKDENKPINVLNDIRIHQTKSLEPGKGVVHLFNNDLRVSNNKGFYEAGKLKADFQVPLIGLFVYCLEELYCHSISNFQLRFKLDTLDVLQKSLGERNIPLVVLKIDRKADYTESISNFMSSNSFNHLTANISYEVDELRDFVHLHQQEKFSFLSFHDTCVVEPGLLASGKGTQYSVFTPWSKAWNKYVNSHSIDDFPAPEPNAPSAANKFDYEAPLVPKNKELNSVQLKNYENLYEPGELAANIKLSEYLKSEKIMKYEEKRNQLDEDVGSHISHYIANGSLNCRTIVKEILKTDLLKQVDQGNKSAIQWVRQVSWRDFYKHVLCNWPHVSMFRPFHLEYSDIKWEYNQDHFDAWCKGQTGYPIIDASMRELNQTGFMSNRSRMIVASFISKHLLLDWRYGEQFFSESLIDCDFASNNGGWGFSSSTGVDPQPYFRIFNPYLQSERFDPHGHYIKKWVPELAEVDEKDIHQPYSKNNYSTINDYPFPIVEHKFGRERALQRYKEARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA86</accession>
    <name>G3BA86_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_94289</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA86"/>
    <dbReference type="GeneID" id="18250380"/>
    <dbReference type="KEGG" id="cten:18250380"/>
    <dbReference type="eggNOG" id="ENOG502QQBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009030_1_0_1"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="875" mass="98094" checksum="A1E388EDAE27A44F" modified="2011-11-16" version="1">MVDAKLGGRKPVKSSSPVVLADGSAVKKKRRAVVKTFFGCDKCRQRRIKCDLAKPSCNNCNKSDVKCPGYGVTLCWLSLPKFTQSGDLVVSSLAFKNENRSQQDIGSNEGFRRRLVGFVKWEKGTSNKPYDTYEDIDQDLMILDNSQADEHVEKLGKTKILGPFGVFQNKSPKLPTSENSAPTISNEHLWLSNELRDDALLTAAALNGDSHLLDFMTSNNISPQVLNTGSHTPVASGNGNGITGSHGTPPPMGPHTPHAAPSNTITNPSDFLNLLFHKNQTQAKPTSTVSTPGSVASPHAASSAGPVATSDLHLDLLSHSDILIDPTNQHLYYSNYNNYFYDNPYKLNENLEIHLHASSKPNKLHESSTDLVEGQNPHVTTMPSSIMNIVQSPLQPKLGFHLLTPSATSVGMPTSALQIQPLTRYLLNHYVNHVADLMTVLPLTESPWKTIYFPRALMAIGELGALGKTSTAKNALLNALLAVSAFNLQSKFPKNSDSMKFYLNLGIRLRNQASLFVRKLLGSSSDMSQQDIESCLKNEKYKDVLCAVMSMISVDLVWGTMQDTNFYIRWCGRVISTKMQHKKKLSPKARVLHRIYSSLKIIQDSTCLSIDNIKHDYRLIDENGYDVNGENFVKSDKKNTEDKNPSSGRHNTTPLFINKKLINTKHHNENFATDALYGLPNSLITLFAETVRLLRHKLYNKHVAEQEDQAYVQAVAQLGLLLDHWQLDWKLYAVVDDEKKFYSSMHQVTFHHIMSFYYALTIYFNRLIKDQHPSTLQDKVKVTLEHLNSIQRLISKENVGIIPLFWQGFIAGCEAVTPDVQVGYKKWGADIAQYLGSYWGARQIMLEVWRRKRLHLAKDDWVGVITDWEMNLMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAJ3</accession>
    <name>G3BAJ3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_131007</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAJ3"/>
    <dbReference type="STRING" id="590646.G3BAJ3"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="150"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="410" mass="46283" checksum="62C7D29014DEB3CB" modified="2011-11-16" version="1">MGDKPKLLSLDAFAKTVEDARVKTASGGIITLVSITIVLFLIRNEYLDYTSIITRPELVVDRDINQKLDITLDISFPSIPCSMINLDILDVSGNVELDILQNGFQKYRILSSGEEVLMKNAPLIDSTPLEVMAKGLDKPEDAEHTPCGDCYGSLPQDRKQYCCNNCETIRRAYAAKVWAFYDGENIKPCEDEGYVKAIQSEIFNNEGCRVKGTTQINRISGNLHFAPGASFTEPSRHVHDLSLYNKFPDRFNFDHTINHLSFGKDPETNANTDKKTLHPLDGETRNLKEKYHLYSYFLKVVSTRYEYLQEKLKAPLETNQFSAIYHDRPIKGGKDEDHQHTLHARGGLPGLYFYFDISPLKIINKEQYSKTWSGFVLGVISSIAGVLMIGSLLDRSVWAAEKAIRAKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAU9</accession>
    <name>G3BAU9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor TAFII-31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114921</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAU9"/>
    <dbReference type="STRING" id="590646.G3BAU9"/>
    <dbReference type="GeneID" id="18247634"/>
    <dbReference type="KEGG" id="cten:18247634"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068315_3_1_1"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000064">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="168" mass="18972" checksum="C23A5C11B72737F4" modified="2011-11-16" version="1">MAERLQNGTSANDGSLGQPSSIVPRDVRLLHLIFATQGIQNYEDHVPIQLMDFAHRYTKAVLKDALTYNDHAKPVNVNTNLNANTNTTVNTDDIRLAIAARTNYQFKPTPPKELLLELAHERNSKPLPQVSPRWGLNLPPEKNCLTARNWDDLDEEDEDEPGKKRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB02</accession>
    <name>G3BB02_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114965</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB02"/>
    <dbReference type="STRING" id="590646.G3BB02"/>
    <dbReference type="GeneID" id="18247655"/>
    <dbReference type="KEGG" id="cten:18247655"/>
    <dbReference type="eggNOG" id="KOG2780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040063_1_1_1"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000002">
        <property type="entry name" value="Ribosome production factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="93"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="295" mass="35012" checksum="046E5B643F2AA0AB" modified="2011-11-16" version="1">MSEDTTKILKGIRNKQRRQKLYADLKHEKNKAKHKARAERATEERNDPSLKEQRLADNVPETLDSKRVYDETIVEDMEGEDEFDAYFASDKPPKLLLTTSKYAKKPAYEFADLLMDFLPDVTFVKRKPQFSINDMVKFCNNREYTDLVILNEFNKKVTGLTFIHLPEGPTFYFSITSVTEGKKIRGHGRSTDHTPELILNNFNTRLGKTVGRLFQSLFPKKPEFEGRQVITLHNQRDYIFFRRHRYLFKSEERVGLQEIGPQFTLKLRRLQKGIRDETEWEFRPEMEKDKRKFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBA9</accession>
    <name>G3BBA9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_124322</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBA9"/>
    <dbReference type="STRING" id="590646.G3BBA9"/>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_0_0_1"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="263" mass="29375" checksum="CD6A7330BCAB9F64" modified="2011-11-16" version="1">MLTLAIGDLYIPDRAIEIPAKFRKLLAPNPQSIPSNNKISQVLCLGNVTSSLETLQFLHNLSPSFHLVRGEFDDTNILSQQLNQLTGSDEVSDVPNYKITIHDNLRIGFTNGYSVIPKNDPLSLSALARELDVDILIWGGTHKVEAYILDGKFFINPGSATGAFGFDWPNDEEDEEDEDEEDEGEEKGEEKLEYEEPASTKSGQIQKDSDPDFTAEDIAQVAHQTSNIPSFCLLETHTSTCTLYIYTYLGEEVKVDKVTYHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBJ1</accession>
    <name>G3BBJ1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNA repair exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_108567</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBJ1"/>
    <dbReference type="STRING" id="590646.G3BBJ1"/>
    <dbReference type="GeneID" id="18246039"/>
    <dbReference type="KEGG" id="cten:18246039"/>
    <dbReference type="eggNOG" id="KOG2310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009535_3_4_1"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="17">
        <location>
            <begin position="295"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV61552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="491" mass="55436" checksum="2E19F7D38AC72D84" modified="2011-11-16" version="1" fragment="single">MDQIDRSIEPGEDTIRILLTTDNHVGYKENDPIRTDDSWKTFNEIVVTAKEQDVDMIVHGGDLFDVNKPSKKSMYRVMESLRSHCLGDRPCELELLSDFNSLSGDLFPVNYEDPNINVSIPVFAISGNHDDATGSSLLSPMDVLAVSGLVNNFGKVTSASEINVAPILLQKGTTKFALYGMSHVKDERLFRLFREGNVKFLRPNMYTEEWFNLLCVHQNHHPYTSQKSYLPESVLPDFIDFIYWGHEHECLPEPQLNPIKNFHTLLPGSSIVTSLIDGESNPKHVFILNVKGKKFNLEAIPLKTARPFLIEAISLAEEGFDPSPVLTNDVTNFLCHKVEELIEKALEKYVQTNTNSSMDTEEAEQFKKDAPLPLIRLKVDVTGGFQVENLQRLSRRFVGKVANVDDIFTIHQKNTSARVKNTDGPKADITFNKSSTLTINSLISNFVEESTLHLLPGQGINNAVKEFIDKDDKNAINEYIKKEIKRETKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBM2</accession>
    <name>G3BBM2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115038</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBM2"/>
    <dbReference type="GeneID" id="18247685"/>
    <dbReference type="KEGG" id="cten:18247685"/>
    <dbReference type="eggNOG" id="ENOG502SR5S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1360248_0_0_1"/>
    <dbReference type="OrthoDB" id="4026474at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="201" mass="23551" checksum="EC24CD05CFFAC36F" modified="2011-11-16" version="1">MILNYCWKHWNQHGEANGKVIQSRTIIFRILCNLKIGVSSIESWGPSRSRNRIEFKVQTIMREITKRAKCNDYLELIPMISQAVEIIEAVSLKFIFYDMLLIILKSHHKCCMHDYLLDTHTDLKEVVQHGFWYKHERKLVAKTQEIFDFLVAVNGQIYSWYTEILQGRIYVSSASGVGPLMRDIPSEYKPTPPGGWKFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBS5</accession>
    <name>G3BBS5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115691</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBS5"/>
    <dbReference type="STRING" id="590646.G3BBS5"/>
    <dbReference type="GeneID" id="18247969"/>
    <dbReference type="KEGG" id="cten:18247969"/>
    <dbReference type="eggNOG" id="ENOG502SZUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014396_0_0_1"/>
    <dbReference type="OrthoDB" id="4082517at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="668" mass="77110" checksum="5491F294B12B8562" modified="2011-11-16" version="1">MDLKRPLPAADDTFAKNLLENPSKRQRLMELSQMSTHMRSPGLGNSMAAGTQIPRFHSRQLHNIPKNGLPIIFPPYQPSDFFTDIDPENVARYAPAIDKMISLFPPPLAPAVPVELESHGEGIMIPFIFPPPPVIKPDPYIDDNAFFLRKRKSFTDQKSPLLEPVELAPLPFPPRNFMPYPLDASKATLTPHDVFTDFLDASTILPRTDMVVASAAGTLTDFKYQADKEGFSIQEYDIDKKRKSQSDAYDRAAEEENSSYYDQINVTDQYDKMYRGLYDPFEPSASQHLSASIQANLSNVKNKPVDKEYSSLLNYKERVLSRHPEAKRLEKYTSYHKSDLNKKRESLLMSLTDIESRQELHKHHLLKTRKKQLITKLRGLRASTVYLTDNENQHLVDEQLAKMKDRMAEDRDSELVKLKFEFNYEVLRQLTSFYQDSDKIYRKFQGTTLNKLLKLMNFFEFQKKQFQKLLESRKMWNELTDLTNKESSKLYSDISERNYGPELKEILKLKLAMADNRGTAEDEARVVQMIENLHTNTFSDSMDKFSDVTDFMPLVSSKEFDLITTNLNKQKNDVKMNMNVKHQIFRSALYESGSDSTYASSFNNSTTSVPDTPKRRGRRSNLEVDEENLNSETFLLAKISKHFVGPQPVNQDQMNEDFEVMGIKSKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBT5</accession>
    <name>G3BBT5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L32e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_95124</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBT5"/>
    <dbReference type="STRING" id="590646.G3BBT5"/>
    <dbReference type="GeneID" id="18250479"/>
    <dbReference type="KEGG" id="cten:18250479"/>
    <dbReference type="eggNOG" id="KOG0878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_4_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="131" mass="15006" checksum="21AD3EB96F71A542" modified="2011-11-16" version="1">MAASIPHPKIVKKHTKKFKRHHSDRYHRVSENWRKQKGIDSVVRRRFRGNISEPNIGYGSNNKTKFLMPSGHKAYLVKNLKDLDVLLMHTKTYAAEIAHNVSAKNRVDIIEKAKKLGVKVTNPKGRVSLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBZ0</accession>
    <name>G3BBZ0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116136</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBZ0"/>
    <dbReference type="STRING" id="590646.G3BBZ0"/>
    <dbReference type="GeneID" id="18248182"/>
    <dbReference type="KEGG" id="cten:18248182"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_0_0_1"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="424" mass="47479" checksum="0898098BAAF6986C" modified="2011-11-16" version="1">MSSIASSSSWTSFLKSISSFNGDLSTLTAPPFILSPTSLSEYSQYWGEHPNLLLAPNFLKASEGADQNELDAMALKRMVAVVKWFISTLRSQYCSRNESMGSEKKALNPFLGEVFVGKWEDTSEDGTLGESILLSEQVSHHPPVTGYAIINQKNNTLLQGYNGIRATMSATSINIKQYGHCLLEYNAKDLAESYLVTLPPLHIEGLITASPFVELEGKSYIQSSNGYVAVFEYSGRGYFSGKKNTFKARIYKDKLASADKENAIITISGQWSGKSYAKKGAIAPTKTDELFYDAFLADPQHLTVKPIEQQHPLETRRAWQKVAEAISKSDYDLINTEKSKIENEQRELRRKEKEAGTPWETRWFDPVDYDSEVKDHFTNLTNLSQLSTKNCPSGSLVGSKYDEGTALHWRVNVDKWNNEKEITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC14</accession>
    <name>G3BC14_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116824</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC14"/>
    <dbReference type="STRING" id="590646.G3BC14"/>
    <dbReference type="GeneID" id="18248462"/>
    <dbReference type="KEGG" id="cten:18248462"/>
    <dbReference type="eggNOG" id="KOG2481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088197_0_0_1"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="237" mass="28040" checksum="8FD40210E7C9410C" modified="2011-11-16" version="1" fragment="single">MRIKKRGTSGNAKNFITRTQAVKRLQISLADFRRLCIFKGIYPREPRNKKKANKGSTAPVTFYYAKDISYLMHEPVLHKFREHKTFAKKLQKALGRGEIRDAEKLEQNRPRYTLDHVIKERYPTFLDALRDLDDPLNMLFLFANMPSTDKVSARITKQAETLTNQWLAYVTKQRLLKKVFVSIKGIYYEANVKGQEVRWLVPFKFPTMIPSDVDFRIMLTFLEFYSTLLHFVLYRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC69</accession>
    <name>G3BC69_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biogenesis of lysosome-related organelles complex 1 subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_111632</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689348.1">
        <property type="nucleotide sequence ID" value="XM_006689285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC69"/>
    <dbReference type="GeneID" id="18246302"/>
    <dbReference type="KEGG" id="cten:18246302"/>
    <dbReference type="eggNOG" id="ENOG502SG83">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2184929_0_0_1"/>
    <dbReference type="OrthoDB" id="244061at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12313" checksum="18C39FFE984521FD" modified="2011-11-16" version="1">MSASRDTGKLAYHGLTTLSRLVESDTEVATIDLNLLENLNTNQALNYIKLEQKLDALDTHSNTLKAIDEEYGAYVKLLDDIDDRSQKLDQLVDELDAWTKELDKSTGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCA4</accession>
    <name>G3BCA4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_116222</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCA4"/>
    <dbReference type="STRING" id="590646.G3BCA4"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19 21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="36"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV61034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="617" mass="70744" checksum="21A8DA31372F07AC" modified="2011-11-16" version="1">MLKNLNKLNVKNMTRQFHQSSVKGDLFKFQSALPKLPVPSLDETTAKYIKTIEPFLSPSQLEASKQKIEQFKKSQGPELQKRLESFSQDKDNWLAEFWDDYAYMSYRDPVVPYVSYFFSHKDVRNEIGKSQVLKATALSYYTIQFMLSVQNETLEPEVIKGNPYCMNAFHYMFNNSRVPAAGSDITKKYDGAEHQYFTVISDNHFYKVPHHINGQPISKSQLYNQFQYILHSSKKLGKGIGLGALTSLNRDEWLSSYEALTKSPINHQSLETIFASSFVVCLDSHSPITIEEKSQNCWHGDGQNRFFDKPLEFFVGANGNSGFLGEHSRMDATPTVQMNNWVLSEISKENPKNFIGEATLEPTLSAELVPELLEWDINPKVRSDIYNAIESFNKTIEAHDEEIFQYYGYGKNLIKQFKVSPDAYVQMLMQLAYYKYTGKVRPTYESAATRKFLKGRTETGRVTSNESKKFVETWTDVDASTEDKINTFNAACKQHVGYLVEAADGKGVDRHLFGLKQMLKSGEPVPEIFTDPVFSYSQTWYISSSQIPSEYFQSWGWSQVIDDGFGLAYLINKDWIHVHISCKKGNGLESKYLKWYLTEAANEMKEILSTQLQKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCH0</accession>
    <name>G3BCH0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116899</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCH0"/>
    <dbReference type="HOGENOM" id="CLU_2460683_0_0_1"/>
    <dbReference type="OrthoDB" id="10552322at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="89" mass="10252" checksum="0E0A7417659D1C39" modified="2011-11-16" version="1" fragment="single">MILSTYQLFRSSVSSAWDFALTLLGFFRKFVETVSNGVVDTFDTIVYYAMNSVMIILSFFELIFEVYEAVDTNVNLILSGYRNGFFKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCM3</accession>
    <name>G3BCM3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_127189</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCM3"/>
    <dbReference type="GeneID" id="18249225"/>
    <dbReference type="KEGG" id="cten:18249225"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008681_7_0_1"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002222">
        <property type="entry name" value="AFG1-family ATPase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="79163" checksum="A3C251CC326BBF0A" modified="2011-11-16" version="1">MSAVATYPSPLHAHPPPSSGPHGVEGRTPNAHAASAATSLSVTDPFILYQNYVSQGLLERDEFQLRAMKEFQKLYHRVIDYRPPEDLQIKISLLLRKIELKHAQQIMDDQAKQGRRLHHVRFGTLSRLFRRDPNAEKMSLIKIITDEEELSNFSSPQGLLINGEVGCGKSMLMDIFASSLPHQSKMRWHFNNFILWVYNEIHSIQNEKILTANLHGYHSRLSMENEFILFEIAQKMINKNTILMLDEFMLPDIASANIIKILFTYYFKLGGVLVATSNKLPEELYSNEFHKSKFKTFVNILNYRCTSVDMRSSKDYRVQLSAQNLSDCNATVVWNNPNHTAEWNRLIKSKVLQIPHQSPLMAPEIAIADSRLGGIPGSFKVYSRVTHLPVTFSSRICYLDFDYICRGLYGSSDYITLASNYSTIVLTNVPILTTKMKNEARRFITLLDALYESKCQFYIKSEVPIDYTFFPDAQDSEAPEEIKQMVRDRNDNNLEVQDEEMFSKTSIATSSPYRPNVSTYDQNHTIEYRESQVSNYKDITAFTGEDEKFAYKRAVSRIKEMVGSTAWRQADRWVPIDDTMRPWEVTSNPTTTRDIHLQPQQLSPEAEEQVDEQIRELLHNKGKLISSLPRDIAGDMRMPFRMFNRKLAPIFSNIQHFWSMGQWNRSRKVKDEIARSWLNSTNMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCQ7</accession>
    <name>G3BCQ7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_137329</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCQ7"/>
    <dbReference type="STRING" id="590646.G3BCQ7"/>
    <dbReference type="GeneID" id="18250055"/>
    <dbReference type="KEGG" id="cten:18250055"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_2_1_1"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000099">
        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120743" checksum="D4F1FF595FB77EBD" modified="2011-11-16" version="1">MTIIIGSLFLPYTVQFEVGLQDTYVEKTSPNTSGIASAKTRPKRPSVTGSMPVPIRSSSILPSLSNANSSHISPSTSPTQHKHTAVQEGGPSSVEDFFLQRYTKPERTTSEIFAENLDEKLQPHFIQPRSMFSKRMDSSVVDIKKQSNDFGLPSLKISRSGTNLTSLNSGGSHSTSNASKSSNVGASRANASLNRSALSMSLQNNSSTSVIDRITEEVDDDDDATIAGHHLDIDSDNDWDNDFNEITNPRAKIKLAPFGGFSHPSLEKGVLSKSSIFETSPWKVLFAAKGNGSLIKAVKMAVGENIIHSRKWVGTLAMPSDEVPQHVKDDISSTLKNEYFSEVVYPSDLTFSGHYKSFCKSVLWPTLHYEIPDNPKSKAFEDHSWSHYKALNQMIADKIVDVYKAENGDLDPDDPENMIWIHDYHLLLVPQMVLEKLPRAKIGLFLHVSFPSSEVFRCLAQREALLKGMLGASAISFQTEEYVRHFLQTCSRLLLADTSDYGISYDGRFTMVNTIPVGIDASSLHESLFSDSVKDWRNRIRERWSDQKLIVSRDKLDKLRGIKEKLSAYEKFLQKHPSYIDNTVLIQVCIGTPSDDDYSADVMQIVSRINAMATNISVSQPVVLLQQDIAFDQYLALQVEADMFIVSSMREGLNLTCHEFIIASTERKSPLMLSEFTGSSNLLELDGQGAVLINPWDVNDFSEKYYTSLTMSPEEKLTRWTNCNSVVACHDYRSWIKGCMASIIEAWKINHERNRINLSTFSKNVFQNFYSDSKGGSRLFFINLETASAITSFADSRPDSVPVSMKTRDIKNSDILPPSHLATLLNNVLSDDNNKVFLCSYMKRSTLDTMFRRVPSMGLIAENGAYIKFKGSKKWISIVNESEIGNWMPQVRQLVEAKVERLPGSKAEIEDCTIIFNPGKSIYEDKHRSIDLMGDLIQHVNLLFDESDGIHASLIRNNVVIQQNQLSLRALNFLVHYFNNNSLNDFKPRVVNDSATSTPIKEKTPSLEYPNDGHGVSGLFVSGGTTSVDEPNFQLGNTLGDQNVIPNVLTVAALDSNCKSTSAKYGVAGRNELLSIISTSIANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDW5</accession>
    <name>G3BDW5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_116452</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDW5"/>
    <dbReference type="STRING" id="590646.G3BDW5"/>
    <dbReference type="GeneID" id="18248313"/>
    <dbReference type="KEGG" id="cten:18248313"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_4_2_1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="580" mass="64763" checksum="51C4046D2F42F5B5" modified="2011-11-16" version="1">MSAVSESKIVEPRVNETALKEEKKYASSGSLKALADEDSQSSSTEEKVEATTEELKTLRHISGSIPIRCWLVAIVELAERFSYYGLSTPFQNYMQNTPSDSPAGVLSLGNSSATALSYFFQFWCYVTPIFGAWIADTYLGKFKSISVFCGIYIVGIFILFITSIPSVADKNTSLGGFVTAIIIIGIATGGVKSNVSPLIADQVPKEKPYIKIMESGERVVVDPALTIQNVFMIFYFMINIGSLSVVATTQLEKHVGFWAAYLLPFCFFFLAVIALVLGRNQYVKVPVGDKIIAKCFRILFIALKNRLNFETVKPSVKPEANYPWSDHFVDEVRRAFFACKLFCFYPIYWLVYGQMTNNFVSQAGMMELHGLPNDILSVINSLAIIVFVPLCDRVFYPLIRKFTPFKSITRIFFGFMWATGAMVYAAVLQYYVYKAGPCYDMPKACNSKYANTPNHIHIALQTPAYVLIGLSEIFANITGLEYAYTKAPVSMKSFITSLYLLTNAFGSAIGIALSPTSKNPKFVWSYTGLAVACFIAGCLFWLIFHHYNDKEEELNQLDYDKDPSEDLIPVASISHSLRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDZ3</accession>
    <name>G3BDZ3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_95868</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689627.1">
        <property type="nucleotide sequence ID" value="XM_006689564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDZ3"/>
    <dbReference type="STRING" id="590646.G3BDZ3"/>
    <dbReference type="GeneID" id="18250553"/>
    <dbReference type="KEGG" id="cten:18250553"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000572_1_0_1"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="7">
        <location>
            <begin position="408"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc knuckle" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="756"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1097" mass="125302" checksum="96D9D65560BCCE68" modified="2011-11-16" version="1">MANKGKKKSKTSSDADGIDLFNEYLSGENGEAANDVPQDQVIQEIFSAKETVHADDAIDYEGIDELADEEDLDDISGDGFPVVSSEPDATEQQAEQDFDDIFGGGDDDDQMDSQNNRLLDGHLDNDPLMGDDGFGNIGIGDIYQENFEDEDSSRKRSMEEDQDYEAKRARLERAVKKLESRQSKRNLRYYYPTFKAGKVFNNHELFITEPQYYSFSVPPIMTKPKPLVPTKVSLQPDFDQRKVFRTGKYPYNYTSQRPNVTEITSNDIRLLESIQENGGLDAKKLVPLSYLQRDGTNDDKFREFSKDLILAVTDWDDEAIINGASKSTATKPSNQKGSSINLDLTDEVEEEEEDENIFNGHIDTELIKLDMNDPNLLFENLKPNTKIKEKLRQLASIPSSNKLLNLKFNISNDKQYEIFKSNYNVKVRSQIGNLNIEHSVPALRLQSPYYKVKLTNDEARSFHRPRFTVRPGTLISFSKVKARKRKKDKGKTSKELFAKSTDLTAGDNTTIISMEYTEEYPMILSNYGMGSKLINYYRREKPDDNSRPKAPLGETHVLGVEDRSPFWNFGYVEKGDFVPTLYNNMIRAPIFKHETKSTDFVLVRSQGGGNHQKYYLKSLDHIFSVGHTFPSVEVPAPHSRKVTNTSKNRLKMIVFRTMNKKGRARINVKDISHHFPDQNDMQNRQRLKEFMEYQRHGEDQYYWKIKNRDTAPEEESIRMMISPEDVALLDSMQAGQQLLDDLSIFLNEEQEKAKVNKEKIQQLEADKENEDDSTTKGKEKDKKKERKEKKEDAEEGIDEQLTSWNLTKNFVSANQAKSMLQLNGEGDPTGIGIGYSFLKTSQKSSFSPLFPPPKENVPKSNQAAYQARLYEEEITRIWYTQRKSLTVDRGKSLQSIYEEYKPLDHDQYLKKKYEDVNSDLTKGNKTLKINRRSRDKNGIVQRKVEVIKDPRIIKAYLKRKKQIEDDLIKNTDLEDILPTNDKELNKIRKKALEEKLANLERRAKHHKGRKSATAKDPLQSVLAAGGKAIDANTVVLPDGSYAIRGKGIGKGKSTTRRCAACGAFGHIRTKKSCPLYNQTQGGTIDIKPPEESGQLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDZ9</accession>
    <name>G3BDZ9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_127639</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDZ9"/>
    <dbReference type="STRING" id="590646.G3BDZ9"/>
    <dbReference type="GeneID" id="18249253"/>
    <dbReference type="KEGG" id="cten:18249253"/>
    <dbReference type="eggNOG" id="KOG0467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="16"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1049" mass="118177" checksum="7870CE6DE780FB9B" modified="2011-11-16" version="1">MKLPVEVINKLQSDPDCIRNICILAHVDHGKTSLSDSLLATNGIVSQRMAGKTRFLDSREDEQLRGITMESSAISLYFKSSKRKEGTEEIEIKEHLINLIDSPGHIDFSSEVSTASRLCDGAIVLVDVVEGVCSQTVNVLRQCWVDKLKPILVLNKIDRLIIEWQLTPSEAYQHMSRVIEQVNSVIGTFYSGERMEDDMIWKEKGQVGDFVEKDDTDLYFSPELNNVIFASAVDGWAFSINIFASFMSKKLGFSQAVLSKTLWGDFYLDMKNKKIIPGKKLKSSQSNLKLLFVSLVLEQIWSVYDVCVMNRDEDKLTKIIEKLGARVSPRDLRSKDHKNLLNVIMSQWIPVSHAILGMVIDYLPSPVKAQNEKMSKLLDECIYNVFSDIEDKSQLIDQEFEKSIKTCDRESPEKNTLAYVSKMISIPNAELPKDFVTPALSKEELKERSRIVRQLAKEASEAAAAAQEAARESTTDEFSLPLAVNDPFEWEYEEDYFDDDEVAPEETLIAFTRVFSGSLSRHQKVTVIGPKYDPSLPKDNLTNKTQIFENIVIQDLYLIMGRDLIRMETVPAGNIVGVVGLDNIVLKNATIISTTRTDDSHPYINLASTSTLIHNKPIMKIAIEPTNLLHLGKIERGLDILSKADPVFEWYIDEDSGELIMCVAGELHLERCLKDLKDRFAKGCEVTVKEPVIPFREGLDPSGSSAFKSEDTLTTEVEGLRLEFETYALTSAITKFLLNSESELAAVRDLKVRNTAAEHSFIDQFVDKFKNVIEDDEEEDSLKFIQKLGFNTAQSFIDNIVACGPKKIGPNILVESTFNHNKFRYLLSSGNPVSPLDLEPHVINGFQLATNEGPLAGEPLQGVLVLIKSCEELEKEEDNEDTFLLGSQGRVITHTRDLIHEKFLFSGARLFLAMYTCEIQAATEALGKVYAVVQKRGGAIISEELKEGTPFFTVVARVPVIEAYGFAEEVRMRTSGAATPQLVFDGFDILSIDPYWVPHTEEELEELGEFAERENVGRRYMNNIRRRKGLFVDEKVVKNAEKQRTMKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3BED4</accession>
    <name>G3BED4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein RSR1</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_136997</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BED4"/>
    <dbReference type="STRING" id="590646.G3BED4"/>
    <dbReference type="GeneID" id="18250026"/>
    <dbReference type="KEGG" id="cten:18250026"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_0_1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04177">
        <property type="entry name" value="RSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000631">
        <property type="entry name" value="Ras small monomeric GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041841">
        <property type="entry name" value="Rsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="233" mass="25808" checksum="11BF17B071A5ADC1" modified="2011-11-16" version="1">MRDYKIVVLGAGGVGKSSITVQFVQGVYVESYDPTIEDSYRKQIEIDGRACDLEILDTAGVAQFTAMRELYIKSGKGFLLVYSVTDENSLKELLALREQVLRIKDSDNVPMVLIGNKSDLESDRVVSIEDGVKVSQEWGLVPFYETSAMYKTNVDEAFIDVVRQIMRKEAAVSAEKKQQKEAAKQTTIANDKEIDTEPVSGAQKEAKASRLKQSLSGDTSTADKSRSRCCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEK5</accession>
    <name>G3BEK5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_137044</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEK5"/>
    <dbReference type="STRING" id="590646.G3BEK5"/>
    <dbReference type="GeneID" id="18250034"/>
    <dbReference type="KEGG" id="cten:18250034"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_21_0_1"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="99"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="327"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="610"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="671" mass="76427" checksum="8429278671C78EC6" modified="2011-11-16" version="1">MCASRKLFKTMSIAMRRFIQIARITNVSTRPALLGQYRLFSNTSFRFNVPQETVAPKESDPEGTLVKLRANEKIDPVISETLNNLNFRALTKVQDESIGPAIDEENGLVVRAKTGTGKTLAYLIPILNQLYPSRSHSLKNKHRVFHLIIVPTRDLAQQIERELTLFCKGHPELKKIFLTRVDVLTGSVRSHLESLFNPSIVIATPGRLIRTLEDKKRFGIRFRDLQTVTLDEADRLLDAGFGKDIDRIHELLTELNVGPQRGVDGLTFKYLLYSATIDKNVSEFAKQKIGENFKYIDCVNEEDTEAHENIRQVLVQTKSFNDSIHAALAHCIRNIEDEADFKGVLFLPTVKAVEWAYDTIKSSCSRINGRQVYKVNGQMTQAARDRNLLLFRRSQRGVLVATDVAARGLDFPDITTVLQASASSEIASYIHKIGRTGRAGKTGEAFLFSHEAESRFVKQLQKEKQIEFNETITYEDFQKDRELFKYSSHDDAIVEAVQSLCLFYSQASNQYGFSTFKCMQQVLEFYREITDSNEKLNLERKYLSVLNLPRHEAEQVFEVPDDYRQNGRRGGSGSRFNKFDGPKTGGYQRNNGRNDRGGYKSDSRGGYGGSRDRDNYRSNNRDNYRSNSRDGYKSNNRDGYKSNRDGYKGNRDGYKGKSGGSSSYERVKDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEN8</accession>
    <name>G3BEN8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_111416</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEN8"/>
    <dbReference type="HOGENOM" id="CLU_053359_3_2_1"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV59939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="125" mass="14091" checksum="C10C49520D0DC83A" modified="2011-11-16" version="1">MANERTFLAWLRTGAIFVTLAITFSQFIFITRAADSVTANGEQYDLDESFKAQVAQLNRFGVVIEIMCMCLGLFSLLAGAFRFFHIQTLLIQNRFPTTRLVILCMVATAAVMISLLIVLDVKLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEP6</accession>
    <name>G3BEP6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_99506</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEP6"/>
    <dbReference type="STRING" id="590646.G3BEP6"/>
    <dbReference type="eggNOG" id="KOG3151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046003_1_0_1"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="77"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV59944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="278" mass="32631" checksum="70B5757B40ABD0B5" modified="2011-11-16" version="1">MSLQSITQELYGTFEQEDYEKCQQLLVPLKIELIKHNLLVPITTDSTTKDQINDFKISQKILEIGALSSLLLNKTQVFENYYSHLKPFYSNSKIHLKKEHNTTSTKIISLYLLLLLSQGLVSKFHIEVEHLTFFQQYDLDSDKYLQFPINLEKHLMEGNYIKIWNLLNDENNLPCKEYIMFVDTLVNALRYEIAKSLEKTYATIPISNCKNLLYFPQEESDMIFEESLKEDLGMNWTFKNGYVFFNSSTDDNDEFKHDKSNKIITNVLNYAEQIESII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEU9</accession>
    <name>G3BEU9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 52A12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_116673</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEU9"/>
    <dbReference type="STRING" id="590646.G3BEU9"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="524" mass="59620" checksum="9F5AEFB6276DDBE3" modified="2011-11-16" version="1">MPTTEEVQAKISAFSTSWVGLLIAVLVVYKIAYTVQNMILAKKMGCKAPTTFLQDYALGFRNVGEMLKNKKSGFLNNFTLQRFNQFGDTISLRVAGNVMFITREPENIKAILGTQFNDFDLGIRYKQFLPLLGDGIFTLDHKGWKNSRAMLRPQFAREQVAHVKMLEPHVQNLFAHIRKYQGQVFDIQTYFFKLTMDSATEFLFGESVESLRDESINMVPTGECDVGLKTRFADSFNDAQTVLATRAMLQQLYFLVNTTRFKEACKDVHGLTDFFVHQALNTSPDELEKKSKGGYIFLFELVKQTRDPKILRDQALNILLAGRDTTAGLLSFTFFELARNPQMFDKLKEEIHATFGAGAESRIDDITFESLKKCEYLKAVINEALRMYPSVPQNFRITNKNTTLPRGGGPDGLSPIFIPRHSTVAYSVYATHRHERFYGKDAEVFRPERWFDEGTKKLGWAFLPFNGGPRICLGQQFALTEASYVVARIVQEFSSLKSFDEQYPPKLNSQLTVNLEDGCHITLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEW8</accession>
    <name>G3BEW8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">CANTEDRAFT_111555</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEW8"/>
    <dbReference type="STRING" id="590646.G3BEW8"/>
    <dbReference type="GeneID" id="18246292"/>
    <dbReference type="KEGG" id="cten:18246292"/>
    <dbReference type="eggNOG" id="KOG2594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024534_1_0_1"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="415" mass="47462" checksum="727EFA44A0A7EE44" modified="2011-11-16" version="1">MSLQILTAKIPCQKCGEDASVTNRKEVVCNECFNMSMRGRLRKSLRADIYKINSKHGVHKVLLAFKGDVNSIVCLDMIMQLVLEQINNHGKTGFQLLVLNIDERNGIEEKLQQVRSFYEQKGTIINYKTVQVNSYLTGKSLKRIGIDKKFNILVKDESSHSMEDIINLIPNKSAVEDFKEVIYDQILLKQAEIEGCGTILYCNSMNKLSSSILANLIKGRGSNMNFKVNDTEKQGIYIKNPLRELFDSEIDYYSEVNEIGQLKFQNNAVISNINRNMTIKQITSRYLNQIEANGYASTIPTVVKITEKLVEPTKFKPIGNCKICDEVIYQNPKTWLNKITHNESAPLVDEIERDYAEQYLQAFPPIEDQLDVSNYTICYGCMVSMNGTESIVWPTERQRDQKVLEEFIIDSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEZ2</accession>
    <name>G3BEZ2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_111994</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689183.1">
        <property type="nucleotide sequence ID" value="XM_006689120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEZ2"/>
    <dbReference type="STRING" id="590646.G3BEZ2"/>
    <dbReference type="GeneID" id="18246337"/>
    <dbReference type="KEGG" id="cten:18246337"/>
    <dbReference type="eggNOG" id="ENOG502QUW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034954_0_0_1"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="136"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV59969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="571" mass="63992" checksum="6D9B965F8F010B98" modified="2011-11-16" version="1">MSTTESPPSSKSSNSRYKDKTIKVLEKAYESVSSVAKDNSGRNRGLAAGTAAAFISLGIDKLNGQSSGLPYTDAEIEAIKEMAESAADETSSKPSTHFMDRLLERLVKHTFTDGDDETDLLEQRITDKNRTSRPGLSLRVLGSNFKKLSSKMTGFFALQYGVIHVITWKRPTKTLCFLFAYTSVCLWPHLVLAYPLLGILFGVMIPGYVYCHPMPYPEIIRVKKRGQSVLDFLTDSGSSSIVDDLLSDEFLEALEEKSNMLASVSSRSSESSAFATSLSPTPTSSNFATPEQVDAYQEKKETSKRIKKQMNLLLNMRDLQNLTTDVVKGMDKAEDIYYDTAGFKDEQLSTLIVYGLFVATTIIVVLGQFIPWRLIFIQSGWAAIILCHPNTKKYLTAIKPKTKKPPPLPARTPPKTPNPSPKPSIYNQVIVDDAPEVRTVEVFELQCKTPMSSSYSLYNYCTSLFDVKDHVRASGRKPIGVDVLSKVSPPRGWKFETKLAREWEFDNDPQAFLTERGLKVGGIFDIRNIEADGWIYDDTTGIPDSDYVFRRRRLYRKCFRYGRQVPRAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF65</accession>
    <name>G3BF65_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Co-chaperone HscB C-terminal oligomerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_100020</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF65"/>
    <dbReference type="STRING" id="590646.G3BF65"/>
    <dbReference type="GeneID" id="18245351"/>
    <dbReference type="KEGG" id="cten:18245351"/>
    <dbReference type="eggNOG" id="KOG3192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068529_1_1_1"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Co-chaperone HscB C-terminal oligomerisation" evidence="4">
        <location>
            <begin position="161"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="245" mass="27819" checksum="00E5894489BE4A2E" modified="2011-11-16" version="1">MVVVRMLTGIALRGFFVGVSCSSFVSITAVFFEWTNCTLTTTLKSYFDLFPKSFPGGGPPSDPFKVAPKALRREFRLLQSEHHPDILIGSQALSKSPEASSGDFSAFLNKAYTTIQNPYTRVSHLIELYHPQHPDISQDDVSKKMIEKFQSESEESSLEYKGMLMTVLDAHESLEFANSEEDLEPLSDENKVRIEETEETIDQLLIETPIDWDKVMLEAIRLKYWVNIQNGIKDWEPGKPVLLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFP4</accession>
    <name>G3BFP4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-sandwich domain of Sec23/24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_109991</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFP4"/>
    <dbReference type="STRING" id="590646.G3BFP4"/>
    <dbReference type="GeneID" id="18246164"/>
    <dbReference type="KEGG" id="cten:18246164"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_1_0_1"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="7">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="8">
        <location>
            <begin position="208"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="10">
        <location>
            <begin position="461"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="9">
        <location>
            <begin position="564"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="872" mass="97633" checksum="2C5835FA50F89411" modified="2011-11-16" version="1">MENNGPNDEESLSVSFQRHRDQLEYMAPTEDGSVVCKSFLTFENVVSPTAGTQFQTVDQGTASSRFIRSTMYNIPETEQLRSASKLPVAVTVRPFAPLLETEDPVPLVDMRTVGRDYLDKEDVGPIRCRRCRTYMNPAVQHTNTDRFTCNICLFPNNKTPPDYAAMLNPSTNQRVDVGLKPELHRGVYDILVPDSYNLGGPDKKPGVLHHVLLIDITVESIKRSLPMVIADAIRSVFYGSSDEVGDDPVPKESKKFAIILFDKRMHFFNLSSNLDSTQITICSDLDDPFIPFFEGLFVDPEESRIAIEDALNNIEQLGSDDSLRADDEPCFSVALRTAMLCLAEVGGGKITAVLSALPSWGPGALKFKDNKTQAATISPEVQKKVYSADNDYYKLLAKDFIKENVGLDCLVVSQTAVDLSNIGWLCSVTGGSVFRWSNFVVERDARDFTGRFVGSIVKTVGYQGQLKLRCSSGLQVAQYYGTSSSIAEISVVGAHTQDPVIPVLSEDHTFTILLEYDGKLTTSHDCHFQAALLYTDSEGVRKVRVINLVLAVSERLDDIFNFVDQDTVVTTIVRDTLSFVGRQTFKELRESLNEKLVEIFTQYRAKSELGHNAKSTLTSRLLMPDSLADLPMYILAFLKSTAIRDSNHISADARLEDVFQMLNMPIERLMYHLYPALVELHSLYPHEGLFPSEDANPSRFISLPRYKDLSLHKLQDGIYIMCDGKRVIVWVRPNANPLLIKDLFGDHIESIESIDALNDELPDLPTDISTQARNIIKFFNSQINGLNNIGSAGIQIVRETLDGSDIFFKEHLVEDGSKLAVNIHNSSYPDYLARLHKAIRVKLENDKTYSKVKQSIRSAENHETLAQKYIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFS5</accession>
    <name>G3BFS5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_132412</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFS5"/>
    <dbReference type="STRING" id="590646.G3BFS5"/>
    <dbReference type="eggNOG" id="KOG0857">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_0_1"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="220" mass="25340" checksum="FEFB2F546E837FE1" modified="2011-11-16" version="1">MARRPARCYRYCKNKPFPKSRYNRAVPDAKIRIYDLGRKKATVDEFPLCIHLVSNELEQLSSEALEAARICANKYITTISGRDSFHLRVRVHPFHVLRINKMLSCAGADRLQQGMRGAWGKPHGLAARVDIGQIIMSARTKDSNKDVVIEGLRRARYKFPGQQKIIISKKWGFTPLNRDEYTAKKQNGEVKDDGAYVKFLSRKGVLEHNLREFPDYQYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFV8</accession>
    <name>G3BFV8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_128311</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFV8"/>
    <dbReference type="STRING" id="590646.G3BFV8"/>
    <dbReference type="GeneID" id="18249295"/>
    <dbReference type="KEGG" id="cten:18249295"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1059"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1081" mass="124096" checksum="F369205D78726C29" modified="2011-11-16" version="1">METILDFSQDLDIGLFDQVVDMFYKGSGPDQQKAQQVLNEFQDNPDSWKKADQILSNSKNSQSKYIALSCLDKLILYRWKLIPTNEQVGIRNFIVNMIIALCDDEEIFAKDKSLINKIDMTLVQILKQEWPHNWPQFIPEIVLSSRSSFNVCENNMVILKLLNEEVFDYSHDQMTQAKSKSLKLSMGAEFEEIFKLCYEILDKTTKPSLVVSTLNCLLKYVHWVPRNYIFETDLLKLLCNKFLSPINTRSVSLKCLIEISSLSSSGYEKNCLEFFKDSMDQIYQIIPPSTNLKKSYQSASSNDQSFLQDFAMFLCTFLSNNLLLLEQLEEFGDLLNNSLYYLIELSKIEERELFKTCLDYWSQFVRELYEEIQRLPQQELSPLMRLNYTPSSRNGIGSGGAPDPSVLAKFPLRQHRYSAILSKLRLVMIENMVRPEEVLIVENDEGDIVREFVKESDTIQLYKSMRECLVFLTHLDVVDTDQIMIEKLARQIDGSQWSWTAINTLCWAIGSISGTMNEDMEKRFLVTVIKDLLSLTEMKKGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKVVVNKLFEFMHETHEGVQDMACDTFIKITSKCKKHFVAIQPQEREPFILEIIRNIQQITEDLQPQQVHTFYEACGIIVSAQNIKESRDSLLSELMKLPNIAWNAIVQQSGRDPQLLTDAGTVKIIANILKTNVAVCKALGPGFYSQLGMIYVDMLSLYKAVSSMISDSVARDGIIATKTPKVRGLRTIKKEVLKMIETYIDKADNLEEIVRDLSQPLFAAVLEDYQNNVPDARDAEVLKCMSTLVSKVGHMIPEGVVLILQHIFECTLDMIKNDFVEYPEHRVEFYGLLKEINSHSFQGLLQLSGDAFQSLINAALWAFKHNNREVEENGLSLTLELIENVEKLGDTPFTKAFYENFYFQVLSDTFYVITQPDHKSGFTYQSQLLAQLVHLVEDNIIKAPLYTPDQAAPGTSNSDYLKQYLGTLLSSAFENLQKEQIINFLGVLTTVYKDQNKFKATLRDFLVQIKQFGGDATDYMFAEDKELEKQEQTRLQRQKDMQVGGLIKPSEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW67</accession>
    <name>G3AW67_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AP-3 complex subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Adaptor-related protein complex 3 subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Delta-adaptin 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_100595</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW67"/>
    <dbReference type="STRING" id="590646.G3AW67"/>
    <dbReference type="eggNOG" id="KOG1059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001908_1_1_1"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000251">
        <property type="entry name" value="AP-3 complex subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="10">
        <location>
            <begin position="54"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="670" mass="76155" checksum="3B32752F66507ECF" modified="2011-11-16" version="1" fragment="single">MSAFQFQSSDVLARLKPFGISFEKSLSDLIKGIRAHSKESPESLSTFLDAAIVECKNELSTTDLETKAMAVLKLAYLEMYGFEMSWCNFHILEVMSSNKLQQKRIGYLAAIQSFKNEEDLLILATNQFKKDLNSHNHIEIGLALSGIASIVTPNLSKDINDDVLMKLGHSKPYIRKKAILAMYKIFLQFPDSLRINFKRVIDKLDDDDVSVVSATLTVICEISKKNPKIFVSYLPKFFEILEETKNNWLIIRILKLFQSLSKVEPRMKKKILPSIVGLMEETKASSLIYECINCIIGGAMLSPDSSKDKETAKLCIEHIMRFFEAKDSNLKFVGLLALISTVKIFPTLIQKIEGVPNIIMECLVDNDLLIKRKALEISHYLINEDNIVDIIKVLLVQLIPAEDSIVPDNLKLEITMKILSIGSQDNYENIPNFKWYIAVLKDIINLTLLPLKSQTATSASLSYQTNRTISLAIGREFKSLVTKVPSIRPNVLKIVTETVLNVKVLDSCPMILEDFYWILGEYIDDLKVSEGADDEESDEEEGKEYGQNSNFAILIPTLVKIYSSIVNDYVSIYSVNGKLPYDKYSELNYYLYKLIKFLGNFENHFFYEVQERSLSWSEFLKICLEASEPHQVPMLLTHVLPSFFKSYALNPISKNGQRNLPAPEDLDLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWB2</accession>
    <name>G3AWB2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112217</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWB2"/>
    <dbReference type="HOGENOM" id="CLU_2960540_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="59" mass="6743" checksum="C74A4881DBCDFCA9" modified="2011-11-16" version="1">MEYFFRYEQGDSPVTDEAGNLIVDDIDMEDCVPLESLCTLSIYREAERNRASAIVPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWK1</accession>
    <name>G3AWK1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_100961</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWK1"/>
    <dbReference type="eggNOG" id="ENOG502RMDI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164919_0_0_1"/>
    <dbReference type="OrthoDB" id="4074036at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11592" checksum="E378CE7D118D3849" modified="2011-11-16" version="1">MSRRTADKDKLRDLNMQLFRSGVVGMLKGTLVGLISGWAINYRYRHLHPHVFRTPYKFAYVLCWAFSGIIFSTEYAKDTITKQLAVEEELKREMYLNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWN6</accession>
    <name>G3AWN6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_112294</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWN6"/>
    <dbReference type="STRING" id="590646.G3AWN6"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_0_1"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="106"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="199" mass="21686" checksum="519EB1D79A07547D" modified="2011-11-16" version="1">MKRYTENIGSKPASHMISASLGEIMACTVRVPVEVIKQRTQVDILGSNSSSLTNLKYILANKSGEGILRSLYRGWNSTIMREIPFTLIQFPLYEYLKSVAPIEEKQSLAAGAVCGSIAGGVAAAMTTPLDVIKTRIMLSEKRTSTRLLVRGIIEEEGYRAFLRGIGPRTCWISAGGAIFLGCYELVHSRLSSLGNTKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX32</accession>
    <name>G3AX32_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112418</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX32"/>
    <dbReference type="HOGENOM" id="CLU_2108720_0_0_1"/>
    <dbReference type="OrthoDB" id="4025857at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="115" mass="12974" checksum="53719170415F4EC6" modified="2011-11-16" version="1">MSRHSVDSLFSNCAGPLASPASSHFDITSHEKPNTNSLKIHMTSASRATAIRLRKDKLKGLADLVKVVEAKFCSFNHLYLDFANKDLKPMAVDMFLQDIIMEYISAKDRIYIRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX40</accession>
    <name>G3AX40_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="17">LTA-4 hydrolase</shortName>
            <ecNumber evidence="17">3.3.2.10</ecNumber>
            <ecNumber evidence="17">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_117851</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="17"/>
    <dbReference type="EC" id="3.4.11.-" evidence="17"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX40"/>
    <dbReference type="STRING" id="590646.G3AX40"/>
    <dbReference type="MEROPS" id="M01.034"/>
    <dbReference type="GeneID" id="18248600"/>
    <dbReference type="KEGG" id="cten:18248600"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014505_1_1_1"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
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    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 17" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="19">
        <location>
            <begin position="473"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="275"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
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        <location>
            <begin position="585"/>
            <end position="587"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002142"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV66683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="629" mass="70751" checksum="306A65F064F0B068" modified="2011-11-16" version="1">MTVNQVHGIPRPGRSPEADPSTLSNYANFQITSTNLNFVINFTSKTVSGDVTFQLTAVASTESIVLDTSYLDVHAVSVNDVAQEFTIGERTGALGSPLVISRACAVDEEISVHLVFVTTSRCTALQFLEKSATDGKKFPYLFSQSEAIHSRSLFPCFDTPALKSPYTMSVTSSLPAVMSGLPQGDGENTETVGEKVYRFTQPVPIPSYLVALASGDIQKLPVGPRSHVYCESPNLKRCQHEFDGDVEKFLEAAEKIVFGYEWKQYDVLILPTAFPYGGMEVPNVTFATPTIVTGDKSNVDVVAHELAHSWAGNLVTNCSWEHFWLNEGWCVYLERRILAEVHGDAVRDFMAIIGWYDLANAIKAMGESATRFSCLVQDLKDGSDPDDAFSVVPYEKGSTLLYYIETLLGKQKFDPFIPFYFNKFKYKSLDTYQFLDTLYDFFSDDHEVLDQINWDSWLYAPGMPPVKPDFDTTLADQCYQLAARWHTAIVEGAKFTELFSLDDLKVLDGNQSVVFLETLIAFNKQDGFVWAHHRDALEALDEIYGPKYSHETNAEVLSRWYFLQVGGHNHKFYEKLGRWLGTVGRMKFVRPGYVTLNKVDHDMAVKYFLEFESGYHPICQAMVRKDLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXC5</accession>
    <name>G3AXC5_CANTC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_117073</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="4080273at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="100" mass="11243" checksum="1AA005A512483833" modified="2011-11-16" version="1">MSGNGIKALSFLLVGSISWYAGVKFWQPLIVEQLKKDGNLRTDVEIPEIETQPESWEDVKSSIRATIHPEVEAKKDNKFAQSLNENVVEIQQNKESNSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXF3</accession>
    <name>G3AXF3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_91525</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006683558.1"/>
    </dbReference>
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    <dbReference type="STRING" id="590646.G3AXF3"/>
    <dbReference type="GeneID" id="18250083"/>
    <dbReference type="KEGG" id="cten:18250083"/>
    <dbReference type="eggNOG" id="KOG0548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399002_0_0_1"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="528"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="646"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="77486" checksum="85D42C6F1C75BAB7" modified="2011-11-16" version="1">MEFIDPSANSEAYRYAFASAMREHLRILKEQIRLKEALSNGEEDMYSDDESEHMSIQTRDTIYHLDSVIGFVFGDILKYHVRHDVEQSKNWGFPSKALTHTFSNILLGADTKEMEIPPRITTSSLIALASKESTSMEFVAQREKELGSVFYSILRNAFELNYKYLWSKDGNGTEQSTIMLSSFVAAFLSRSVECYPQVFSRREYLADRVNYVVKELENYSQVQTNKVPLESLYEFFGVLLKSHIELLISRGSLLAESSKVVTKLREQGNNLMSNYAYAQAIKVYTDAIHLCSGEATKNLPQIFVNRAIAYIGLTCFPEAIMDLNLALKYDISFVPAWTQLSYAQLYMGNSLMALKCIAMALSCCCGEVLPYNFPKEPSYMIEYRANKKRSTLPQFVEQILKSVELTERRAKQQRLNKQEISDVIQKVKSCISQLADAAPDEDKHYFEYPPRSSEPSTFVDLANRVNSNRPAIYNPEASQTVTTAAAEATTAIAPQNATPRGEPAPPIVDISTAIQGVVGNSFSGLQANMRPGRLYPDSNQSPPAATPRRPTNQRGPWTINGRRVRSIPLDETSEETSLINSLGPSIAEIVREGRRLRRTSEGQPNRDTEQERNRYDNAVRFFTSRASDIPGAEQFVDDFARVDQSSGIGLTSHSEGPNIWNSSTQHTSNTRSDPNPNNPHPGIPESPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXL5</accession>
    <name>G3AXL5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112519</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684689.1">
        <property type="nucleotide sequence ID" value="XM_006684626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXL5"/>
    <dbReference type="STRING" id="590646.G3AXL5"/>
    <dbReference type="GeneID" id="18246557"/>
    <dbReference type="KEGG" id="cten:18246557"/>
    <dbReference type="eggNOG" id="ENOG502QSAH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061203_0_0_1"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39594" checksum="031E8451F316A093" modified="2011-11-16" version="1">MGIIEEARHFLDNSLPEEALELLTSKLVENQADIEYLQLYGEVLLENNQVEDAYNLFIKTCEMDPIADKGVEKFLYLGQIIGGEDGIAYLDVGLNKLNEQFENGNKDIKTIKKLNEGIFAKIEIWMTDLCMEPEAESKCDELIDYALKVDDSYPETYSLLASIRISQQRNEDAEEALARSWELFQQRKQKIQLESINDEMNFEVIELIQPFITIIKFAIELELYDLAIEVCQATQDINDQILDIYYYEVLANLFKSKQQYPQRDKQTDYRDLPNSVVDEDTKSDVKLILTSAFKILQTSDDLDPELTESINSLLAEFGGPIMSELMPQRGDDNDDGWEDEIDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXP4</accession>
    <name>G3AXP4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GDP/GTP exchange factor for</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_101550</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AXP4"/>
    <dbReference type="eggNOG" id="KOG0928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001204_3_1_1"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="529"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1441"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1442"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1455"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1494" mass="164840" checksum="CF1BE531CF9D0D89" modified="2011-11-16" version="1">MSGYNSTFHVQSSIAATGAFSSFAIDPLTLAITECMAMSSAMRKVSRYQQSGMAAILGSGNDFFGGTGADDDSLTTNLGFAPTNRHGSHGPPHPNGTAHPSTAMPLVSSFVQLRSMLSEATDIEVLDSLTVLQPFLLVVKSPSTSGRITAMALEAISRFLQYGVLTDRSPNLGPTLGQICSALTHCRFEAADQSSDDAVLLKVLRLMEAVATSPHAGLLPNDVVSEVVQTCLSLACNKKRSEVLRRAAEMAIGNITARIFARLSELPEQESGSVVVGELPEDVIGAAAARKESDLAEDDRVLEDKDSNSDDGFDVSALIEFTSILISMISPSNQYQHMESTRVLALRLINTAVEVSGHHFYTHPSLMSLFTDPVSKHVLQIIATVESPALLEVAWRVFATMAVVLGPHLKSQIELTFSASSSVVAGSTFASPTAKEMFLESLSLLWTRDPYFFTRLYADYDCDFDRADLARQLIEFICTLALPESARVSTDNVPPLCLEGLLSFVNGINERVKKGQFLESSSDLDEVPRRLSNKANKKAFVECTDEFNKKPSLGLAALVRHGFIKDPNDIAEVSQFMYNKSGRLNKKVLGEYLAKSSNKDLLKHFMSLFDYEGLRVDEAIRLLLKTFRLPGEAQQIERIVETFASRYAECQEEKQPDSKEADQPDVSTVRPDEDSVFVLSFSIILLNTDLHNPQVKKHMTLEAYKKNLRGQYNGGDNYPEWYLSKIYSSIRDREIIMPEEHHGTEKWFDDVWNNVVSAEALANNDLHEEVIDDISVYDKNLFADTVGVITKTLVQIFNEATDDHIITRLMSTIDKSVNICLQYGILEPVDLLIGLLADLTTLTDPAGLKRNKDESDDNLRDEIPITQIKLEGKDDTITVSDVAVWFGRDFKAQIATVVLFRLLKKTKCRVTPAWEKVIKIILTLYESCLVDPNMYSEFQKTLSLPSLTRAKPRYIINRSKPLRESGLLSTFSSFLKGYSDEPPEPTDSEVESTLSTIDCVKSLDLVALFKTVAEGGQENKILLAQLLVDAIPEKLDDVSKRYYESEVLFITENSVFLALLSNDKLLFKKIIQKISKVGGTLSKKGDLRMAVYELVLWKELSTLTDDPSAEDEIVGNIELPLGSVLSLDKDILTKFGEPLISPLISLVSTSSTLSQQLLSSKQYWKVLRSIGAIPVFSSKVLGLTESLIKESVDDISPENFMLVLGLLDEISSVGAFAAQWEQDSSNHAKAQGKEDKSKYLRELINTSKKSIALTSELSYVFGKDGFTRDNAGYPLVQALAHQCFNPCREVRSTALNTLKSTVLTAVESHDNQLPPAGLFQFGLFPLLGELAKPSVIQTDPQGFVTTQVEALSLCSKVFLHFIGKFSEEEIQITWIGILDGFKSFDDIQKAATTEDNSANHESGMELLKNMLLVLQSGGVLSPENKELWEPTWTKVSSIYSELRPESEAKEEPADTTATGSRSNADPATETIDPVIEQSAEDAQATVSNDTDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXQ1</accession>
    <name>G3AXQ1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112541</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684244.1">
        <property type="nucleotide sequence ID" value="XM_006684181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXQ1"/>
    <dbReference type="STRING" id="590646.G3AXQ1"/>
    <dbReference type="GeneID" id="18246569"/>
    <dbReference type="KEGG" id="cten:18246569"/>
    <dbReference type="eggNOG" id="KOG1469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_1"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="49"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="145"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="267"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="441" mass="49224" checksum="E375F5089EEBF9FC" modified="2011-11-16" version="1">MTDLDIPAVFLDKISPRGLEAIRKTYDFVHNYCIPADALYFDQISQDPEQRWKTTPEVTEKLKQKAKQLGLWNMFLSKHYTDGPGYTNLEYGLMAQFLGRSFVAPEATNTGAPDTGNMEILAKFGSAYHREQYLLPLLRGEIRSAFLMTEKGTSSSNALNISCSAQKNSHGNYVLNGVKWFASGAGDPRCRVWLVMCKTESSDNIYRNHSVLVLDAKKALASGKAKLIRPLSVFGYDDAPHGHCEVEFNDFEVPAEDMDNSILGKVGMGFEIIQSRLGPGRIHHCMRLIGAGEYALMRAVSRAAGRDIFGKPMVKRESFLNAYGEHKLSLQKCRLLVLNAAHQIDISNAKTAKRDIAMAKIETPRAVLKILDWCIQVYGAEGVSQDTELAKMYAHARTLRIADGPDEAHLGQLARDESKKFAEVVKYFEGHKARQDQVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXV4</accession>
    <name>G3AXV4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_102003</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684276.1">
        <property type="nucleotide sequence ID" value="XM_006684213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXV4"/>
    <dbReference type="STRING" id="590646.G3AXV4"/>
    <dbReference type="GeneID" id="18245523"/>
    <dbReference type="KEGG" id="cten:18245523"/>
    <dbReference type="eggNOG" id="ENOG502SYY5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852575_0_0_1"/>
    <dbReference type="OrthoDB" id="3997968at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="326" mass="36532" checksum="F64D09793A4CF92A" modified="2011-11-16" version="1">MKADRFAPPSTPPRLRKGVTIGPSKFGTLKTPQSTSKKVQNFFSAMNSGSTNTSHQPQQSKHLLAPITPEFTPHKSPRLQRRKKIENIFKLESPTASVTPNSFHQDHFGLLLPTPSTIGSGRKSATSSNANLTKIKPAALKFDALTSLNNGLKFETDMEEVDQEQPESSDEMDQFFLKPTDTTKFISNSNLRMLKSPTRISRNPFEEPSSPVSRAPDVPSTPGHQMINDFTVHEWYGNSAKYFSDDEADEEQVIRKRQPMVNPFLSANPARKANLNIQNPFNSNKSQVDYSTHLELVNNKTGEKKIVRLSERQAHIRPKKLDFSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXW6</accession>
    <name>G3AXW6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_96818</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXW6"/>
    <dbReference type="STRING" id="590646.G3AXW6"/>
    <dbReference type="GeneID" id="18250632"/>
    <dbReference type="KEGG" id="cten:18250632"/>
    <dbReference type="eggNOG" id="KOG1989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011638_4_0_1"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000441">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="490"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="607"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="490"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="723" mass="80072" checksum="F6F9B46FEFE3B012" modified="2011-11-16" version="1">MPSAPPNAYAPGANLTVGSHNVSIIKYISSGGFAHVYTCNIDPPFRGSPVACLKRVQVPSKWQLNLLRQEVDAMKRLRGNPTIVSYIDSHASRLNNQGHSTIDAPGSSQQYEVFLLMEYCSNNGLIDFMNTRLTNKLTEPEILVIMRDITLAVAMCHHLQPPLIHRDIKIENVLLDEKGTYKLCDFGSAVPYAPVPKTSQELQLLKDDIMQHTTPQYRAPEMIELTRGFPIDDKSDIWALGCFLYKLCYYTTPFESQSHASLQDLENSIVNSSHTLHIPHNRPGSTFSPRLRNIIKCCLREDPRRRPNAVQLLDEVCVMMNIPAPKVVPASVIERPSTPAAPMQPSNGSVHSKSSSDLNSINRPPPFEGRKPQTAKTDPFASIDKSKLLQTTRQHPQQRPKSLYAAPRPTSIYGGRDISPIGTSANTHQSSNTLKNYIQRQLSKSNESIITPPDEDDNTLNFLRDMEDISSQNTGGSFKASFKNGLRKISTGNSSSGVRSSNNTGNNYISNHRRSSISSIKQILTGGGSRKASNHEESEFKRDTEQTITSSSFTSSAPKKLSIQRRMVQYLNNNNDQTVKRTAHGYGRYTAEESDTDDLEAINDGSYKSRISLNPPQVPTSLSSQRAKSATPPHPSSSPAAVLAKPKYKHSSTNTSEKALPSITPSKMRNSLKKPPPKPTKPVYLRTAEGDSSSRRLSSSSEISIPDLDDLEKQFAKRFPSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY78</accession>
    <name>G3AY78_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Thiamine phosphate synthase/TenI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_101804</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY78"/>
    <dbReference type="STRING" id="590646.G3AY78"/>
    <dbReference type="GeneID" id="18245501"/>
    <dbReference type="KEGG" id="cten:18245501"/>
    <dbReference type="eggNOG" id="ENOG502QS2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019943_1_1_1"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="7"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV65784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="520" mass="55892" checksum="F2AF3A6289EE1527" modified="2011-11-16" version="1">MNVDYTLYLVTDSTMVPESSTFLKQVEDSINAGATIVQLREKSISTLDFIERAQKVHELTKKKNIPLIINDRIDVALVVDAEGVHVGQDDMPAKLARQLLGPNKIIGVTCSNPSEVQQVCDEDVADYVGIGTVYKTLTKTDTKTPMGTGPIGIRKMLQTLKTRNTNRQPIKCVAIGGINETNVTKVLYQCSIPGQKLDGVAVVSCIMAKEDAYKATVELQEQINGIVPWKKDGMSKFDTFTYNNSHLEIQTQKIQKAGALVHHITNNVVKNFSANVTLAIGASPIMSELAEEYEEFAQKIPNISLVLNLGTPTVEMMQTFIHAITTYNKYGKHVIFDPVAAGATNARLECSRVLLNAGQMSVIKGNVGEISAIFKLTSTYEVAKNEEVLMRGVDSIANLSEESIRNIGYAVSQDFKCVVVITGPTNHVIDAESGSFAQVPGGNKLMGLITGSGCSLGSAIGSFVAAKADSSATENLNLFEAVVGAVTLYNAAGKLVGTKCSAPGAFVPAFVDSLYLKANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY99</accession>
    <name>G3AY99_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_129253</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY99"/>
    <dbReference type="STRING" id="590646.G3AY99"/>
    <dbReference type="eggNOG" id="ENOG502QQWB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008201_1_0_1"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="212"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="466"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="95879" checksum="0B4EFF8B036E9A82" modified="2011-11-16" version="1">MSFTDSFWTSEYNTGCRVLFDQLYEGVKENEAFIKLFEKRSESESIYGNLLNSINLTPGSSKRMNDDNYVSSIKNAYSKINENFVGQGNYHVELSESIDSRVISPFSKWCKEHKERVEYSDSVLSEKYKAFKTYKLNLEKVQKKYFNKCRILEDFKNHLDEDELSSGIENLSSNISRSTDDENDKDDFLGEVYKFGDLSFDEANLKQLLKDLIKNIDIKDHKVAILGTYNNVSSGSSITQWLLKNVPGLQNDFDKVEGFGQDLINHGFIRLIGTINNNKNFINSSQFYYQWKPKTFDLIGYDNTDEVLSRSSSVIQQKTQISDYFEDMKQVIGVNSVDFNDKGQYIKISQEVNYLDQKYYQMVLELDKLRCNLEELIMDHLSFMEKCEFDRLKAIRKVLFDFLKVFQEAFKDNKTFLDELSILEETINPVNDLKFFIENFKIGKFKPTVVLYDNYYNSNVNQSFGVDLTIKSRLDKKVVPILVQCCLSHLDRVYPDVINDEERINLWEKPVSLSNIHGLRFKLNHLNTTEEITEVLKKQHPLIITNLLKLYLLELPDSLISSSYFEIIKSLYTNYPINTNDESIDNSRINGLQNVLVEMPKCNLATLDAILTHLNRLVQIIGKKDPELAGDFKVKLSKEFSSILIIPKHHGHFLADNFQFNLMVDLFNNKEIIFKELRRNNSGNDRSGDSIRKKKKAQMNSQESNKSNLPSVPVKNEVIRDAIQRAPVTPKPIEKDAPSTPKSSATTPGLRRSNSPNKKSLNSYLDKGTRSTAKQTSTPIVSSLPAKKDINLSELGQPKFAPSLGRRPSVKDLAQQFDSPSTSPTPKSSASSAKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYF4</accession>
    <name>G3AYF4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_101522</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYF4"/>
    <dbReference type="HOGENOM" id="CLU_2312714_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="100" mass="10927" checksum="2379FD26A6416C20" modified="2011-11-16" version="1" fragment="single">RILPSRFLSLVNSLTVSPTFMVIPFSSVATCSRRSSFNLDAIPDGLTFMNLPSEVSTWKRSFSVLRITPTVEALNSTKSLISYLLSLDATVSDVSVALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYI0</accession>
    <name>G3AYI0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_92193</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYI0"/>
    <dbReference type="STRING" id="590646.G3AYI0"/>
    <dbReference type="GeneID" id="18250167"/>
    <dbReference type="KEGG" id="cten:18250167"/>
    <dbReference type="eggNOG" id="KOG2110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025895_5_2_1"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="602" mass="66481" checksum="77B56788EC18A672" modified="2011-11-16" version="1">MMKNSLNTGLHPPLYSNYNNYTDDGNSSIASSGKYSHLQGKEPHNQVNYITFNQDNTFVAVGLNTGYKVFNCVPSVEKCYQDVKNEPIGLVEMLYNTSLVALVGLGEDLGSSPRKLKIINSKKNSTICDLVFPSTILGIKLSKQRLVVLLETQIYIYDISTMKLLHTIETSPNPNGLFAFANTDMTNSPNTFLAYPSPPKTIIHDTLLVNGINTNGGNNSVQNNIQSVSNSPNRVGDVIIFNTITLQPLSVIEAHKSNLAALTLSNDGTLLATASDKGTIIRVFNVLTGVKMFQFRRGTYSTKIFSLKFSNDNVFIVVTTSSGTVHIFRLGEEESLEAKHKNKRKKKTPLINEPTIEEENEEEDAESKRATKMINSKTNDTNDDEIDVDDNEPDDDEIRDDGDDSDAEDGIDEVDEDAEQALGLDIPKQRKLSESSTGSFTSIYSGLSNEDIPSLNNGGGGKSEPIVDQTRLSMARIIRRSSQTLGRKAAQKMGDFLPSRFSSILEPTRHFASIKINSIGKDVKAIAAMNNELQEDLVPQQYLTKNSENKDIEIEIDKSKDLLNMKLLHINVVTSEGISYTYGLDPERGGDCILLHQYSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYS0</accession>
    <name>G3AYS0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112791</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYS0"/>
    <dbReference type="STRING" id="590646.G3AYS0"/>
    <dbReference type="GeneID" id="18246675"/>
    <dbReference type="KEGG" id="cten:18246675"/>
    <dbReference type="HOGENOM" id="CLU_959749_0_0_1"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="290" mass="31190" checksum="EA8CDD47FA3A22D0" modified="2011-11-16" version="1">MNGGKKSNGNSSHSGNYNSNSSVSISSFQTQPIDIGNFNKNVNSPNKSANGNLGSNNNGSSQSSRVSQTINYTPTSSSMSLENNTQASFNSALNYSTSVYSHHAGSINVGSYGVTGTLTPSSNPVTTTTPRSAFASTNAFGSLSASTSPIGLTQDLSNSPQQSNFFSKNQPISYSPTNNLSLQISRSFSSKLPASHGSFSSYLNVFSESAIIDDEIKDTVDDGFFEEDYVPASLGDDILTPQQVQRRDSRSQSGTLLVRPIFKTRDSKFDNEYDEQKKSVFVQDDVFLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYW1</accession>
    <name>G3AYW1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="6">HMG-CoA synthase</shortName>
            <ecNumber evidence="6">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_92289</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="6"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYW1"/>
    <dbReference type="STRING" id="590646.G3AYW1"/>
    <dbReference type="GeneID" id="18250181"/>
    <dbReference type="KEGG" id="cten:18250181"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008065_0_1_1"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="8">
        <location>
            <begin position="175"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00073381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="444" mass="49280" checksum="7A5237D40EB5EE80" modified="2011-11-16" version="1">MSRPQNIGIKALEIYIPSEYVNQEDLEKFDGIPQGKYTIGLGQTNMAFVNDREDIYSLCLTSFSKLIKNYNIDVNKIGRLEVGTETLLDKSKSVKSVLMQLMEGNNDVEGIDTINACYGGTAAVINAVNWIESSSWDGRDAAVVCGDIAIYSKGAARPTGGAGSVALLIGPDAPIVFESSRGSYMEHAYDFYKPDFTSEYPVVDGHFSLSCYVKALDNCYKNYSKKVTKDASKTVGVNHFNYNAFHVPTCKLVTKSFARLLYNDYKSDPSKFNFDEETAKLVDVDYETSLVDRNLEKVFLGLTKETKKTQLDPALKVPTNTGNMYTASAWASLCSLLYYVGSEKLQDKRIGIFSYGSGLASTLLSAKVVGDISHITKNLDIDYKLGEGRTKRSPEQYVTAIDLREKIHLQKSIAPTGSIETLAKGTYYLAEIDDKFRRSYKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYZ8</accession>
    <name>G3AYZ8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Monothiol glutaredoxin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112844</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Heterodimer with FRA2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYZ8"/>
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    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
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        <property type="term" value="F:disulfide oxidoreductase activity"/>
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        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
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        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Monothiol glutaredoxin"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
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        <property type="entry name" value="GRX_PICOT-like"/>
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    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="239" mass="26530" checksum="2F0EA340319A3E09" modified="2011-11-16" version="1">MPVTEINSEDQFTTLSKTKDTLISLYFHTEWAEPCKTMNSIYSTLSDTPDNKEVLFLSINADNQSDISDLFDVSAVPYFILIKDSTILKELSGADPKEFIGTLNELRGTTSTAATTASPTQPALEEAPKSQEDESPEALNARLEKLTKAAPVMLFMKGSPSSPQCGFSRQLVAILREHEVRFGFFDILKDDSVRQGLKAFSDWPTFPQLYVGGEFQGGLDIIKESIEDDPDFFKHAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ78</accession>
    <name>G3AZ78_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_112891</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Oxidizes long-chain alcohols and, in the presence of glutathione, is able to oxidize formaldehyde. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="13"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ78"/>
    <dbReference type="STRING" id="590646.G3AZ78"/>
    <dbReference type="GeneID" id="18246724"/>
    <dbReference type="KEGG" id="cten:18246724"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0520">NAD</keyword>
    <keyword evidence="5 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="14">
        <location>
            <begin position="20"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="379" mass="40131" checksum="1AE3422873702B04" modified="2011-11-16" version="1">MSDTTGKTITCKAAVAWEAGKPLSIEDVEVAPPKAHEVRIKILNTGVCHTDAFTLSGVDPEGEFPVILGHEGAGLVESIGEGVTSVKVGDHVVALYTPECKECKFCLSGKTNLCGKIRATQGKGVMPDGTSRFTCKGKSLLHFMGCSTFSQYTVVADISVVAVNPKASFEKTCLLGCGITTGYGAATITGDVQEGDNVAVFGAGCVGLSVVQGAAQRKCGKIIVVDINDKKEEWAKKFGATHFVNSATLPEGTTIVDKLIELTDGGCDYTFDCTGNVHVMRNALEACHKGWGTSIIIGVAAAGREISTRPFQLVTGRVWKGAAFGGVKGRSQLPGIVDDYLEGKLRVDDFITHRHSLDKINTAFEDMHNGDCIRAVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZF3</accession>
    <name>G3AZF3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_97138</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZF3"/>
    <dbReference type="STRING" id="590646.G3AZF3"/>
    <dbReference type="GeneID" id="18250660"/>
    <dbReference type="KEGG" id="cten:18250660"/>
    <dbReference type="eggNOG" id="ENOG502RXN8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032834_0_0_1"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="167"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="36558" checksum="01D74DBE70F91F61" modified="2011-11-16" version="1">MVVFTSLGMFIIDENVYETAPGQPLRAPEYNIVGGGGSYAVVGAAMISANLASQVSGIIDQGKDFPPPVRRELDSWGTALVFRTDPERLTTRGRNTYDRYGTRHFDYLTPKKRIELADLHQLPSLLHSKCFHVICSVDRCQELVDGIRAVNCDSQFIFEPLPTDCVASRWEKLHQLLPHIDVFTPNLEEACSLMGMSVVPTDVSAIESLARRYVDLGAVICVLRCGALGCVVATATNTTHLPAYHQDQAGVVDVTGGGNSFCGGFMMGLYISRNPVAAAICGNLVSGCVIEALGMPQVEARKWNGRTMAERWEQYVSNAAVAQVAVAADVDMGWIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZS3</accession>
    <name>G3AZS3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112965</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684913.1">
        <property type="nucleotide sequence ID" value="XM_006684850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZS3"/>
    <dbReference type="GeneID" id="18246761"/>
    <dbReference type="KEGG" id="cten:18246761"/>
    <dbReference type="eggNOG" id="KOG2174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134810_0_0_1"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16028" checksum="AE088017A2E5AF56" modified="2011-11-16" version="1">MNSTESFRGNPLNKIIGLSIVLSMGFLLVVLAGIYGNWYPIINGIICAIAHLPVAITKALTSSNDYDFNFDPVTSSQGNFLKEAGQFVSAFLVVSGVFLPVLLHHSMILTKTAMVLTIVGGGLIYGTVYTFSTYFDEPEEDQLGEDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B069</accession>
    <name>G3B069_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_102915</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685017.1">
        <property type="nucleotide sequence ID" value="XM_006684954.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B069"/>
    <dbReference type="GeneID" id="18245591"/>
    <dbReference type="KEGG" id="cten:18245591"/>
    <dbReference type="eggNOG" id="KOG0309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001497_0_0_1"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16488">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1388"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="699"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="826"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="900"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1193"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="900"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1195"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1439" mass="163440" checksum="907C23712C3C8F11" modified="2011-11-16" version="1">MSKNPFDSVTFGSSLSLRVDGAIGAMSLSPNGRDAVLAGRRGLFIIDLDEPFTTPRWLHHITSWEVADVQWSPHAGAKPSWCISTSNQKALLWDLSRPSDSAIVNVLHEHTRAITDINFHPSDPEIFATCAIDTFILSWDMRTPRKAVQQWAEWRAGATQVKWNHKNPYEIASSHDHSFYIWDTRKGAFPVLRIEDAHGGKINGINFTDGVSNIITCSNDQSIKFWDLSNFQGTSDAIEGASGGFSPSIIVQTDFPVARARTLPFGSDKSCGVMPLRNGQDSIHIINFDAAMERYTNTKETQLLELDPIYSFKGNSGPMKDFLWRTRHEHYEGFDTKRTWKDYQLVTWSSSNYDLKLWPHDEELYRKVNYNPLVQKAFKQLPLIASPEPDSNSRTSSSSALVTSDSHNYNTYCTEPPLTLTNILYKNKGDLLSSMTMFQIAKKHKHLPTVPSQLNHLAWISGVRMGRNNEQADKMENDDPTPLNLGEEVTFVAHMFPKVRFEKISVSTGELILSLRGPLPAVESSSTVTDVQEEKDDTKAINENTSSEAPNLENPSSSTENPDPTDPKDTLQKEEETEQFPDQENEQKLVFIRLEITFPRSYPYLDDVPLSSNMTKKFQKNNFISFNIEETYDLTSDIKQEMVRNLTDIALFFSNRHQRFCLEPLLRYLMGDKIALDDSLIANTPLNEETEIIQEVGNEDWADDLIDQQPSDTIPTDDDDDFDDQLSDFMPALNDEEMVNSTGSLGKDSGEDPATLALEASVNDEVGNANKFYDSTPVPKGCGAYWARNGKLVCFFIPKDTEEEDSKALQKFSIFRFTDAGFSVNTANGDGDDEDVLDKTDKAGTDTDNESEFSEESDSSTTSSDSFVDEWDDIDEDDLASRFRVPGLFKTSVGLGNRYVSRTRNMNRPNKNSQGGTASNYKSSLPGGDSDFQSSKKRKNKSNKKAKNIVGVFDFSHLIPDKKELAQEYRVLGDSPEKLAKYNSQVALKYGLTEICDTWRLLEMILIKDIEINDIHPVYHSSAVIQKSNSNSTIAKNVEAMNHLLKINEITKKFFGDQTYRFYWGSHPYGYSWLVKEMLNYFERRGNLQMIVMISCILYENTKNVSSNKDIFNIPIHTPYEIKPQPPSMAQIRKFNESFNNKLERNFSFHESLSTELSDPKIENFYDIPRHKNSSVSVIRRETPARYARSIGSDEFIKDESPEHQGSRHNSSLSNAIAPTDSFLRKSFTMSPTVEIEMRSRRGTEYRKPKGIASNVNNRKISRKGSARPPPVVNIEFQNVDSLDLFDDLYTKSLLSLQEDKKIKMYREQYAEMLYCWGLPANRIKILKFNYPNPEKANSKFEEHRCSFGFREKAKTLTGVPYVHSNSTIDSSKENPWNLNKANQLKYCNLCNLLVSKRLVVCTNCEHVLHSSCALEWWSENEEQECPSACGCKCLNYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B097</accession>
    <name>G3B097_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Urea transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_119625</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685037.1">
        <property type="nucleotide sequence ID" value="XM_006684974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B097"/>
    <dbReference type="STRING" id="590646.G3B097"/>
    <dbReference type="GeneID" id="18248715"/>
    <dbReference type="KEGG" id="cten:18248715"/>
    <dbReference type="eggNOG" id="ENOG502QU2F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023225_0_0_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55835" checksum="A6CAE934A5B44995" modified="2011-11-16" version="1">MGQLSSQGNNAIIYLTYAFLLATGLFLAFKYSKSATFLSSNGTQRAAPLVLNFVASAMGCGVLTTYAQIANISGLHGLLVYTICGAIPIASFGFFGPIIRKKCPDGFILSEWVRHRFGIVTALYLSLFTCLTMFLYMVAELSSVSLAIETLTGLDALGAVIVECVVTTIYTSVGGFKVSFITDNFQGALVLLLIIICAAGMGSYIDIDTSKIGPSHLLQANKLGWELIYVFFVAVGTNAFFLNSFWLRTFASKSDRGLAIGTSVSAVIVMVICTLVGVPGFLAVWSGDLTVGDENGSMAFFILLAKMPGWIIAFVLIFTITISTCTFDSLQSAFVSTISNDIFRNRLKTIWVRAMVVIMIVPIVVLAVKVADNILQIYLIADLISSSIIPIIFLGLSDRFFWFLTGVDVMVGGLGALVAIFIFGTVYYGTAKEGGKLLLIWNGLYDAEDWGAFGAFVIAPFGGILIALVCVVARVGAIWVYCKITKKPFTALQRPVPVEIVEEEFDSAYGSTNAKSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0U7</accession>
    <name>G3B0U7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113579</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685612.1">
        <property type="nucleotide sequence ID" value="XM_006685549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0U7"/>
    <dbReference type="STRING" id="590646.G3B0U7"/>
    <dbReference type="GeneID" id="18247028"/>
    <dbReference type="KEGG" id="cten:18247028"/>
    <dbReference type="eggNOG" id="ENOG502QU4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042692_0_0_1"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44750" checksum="BA24712E7D7F5B9A" modified="2011-11-16" version="1">MSKSTDDQDVLEFINSLPDSKSNTPKPEGKEEDLLDFLDELAAHDKKPSKLSPKKKEDPKQEQEQEQEQKPTKPSAAAIESANEELEIDPINSITNWWNKEGSTAVSSLWGSITTNATTLSETTYKIASDTTNQLNTKRQEFMKDQEENGGKNLQQITNLTNRLNNILSNITEQINTIGGEDELINLVIVNDLNNLTYLNDLISKNFGKVMNQVEGGIKVQINNYNHNHNQGDEVDLNMFTGKLIDGEKLCLANLDNSVKNFNKAIEFEKQEQTELNEKLNLINRSNVFISIQPINVSGEVNKDDDEIVIDQTNPSSFFFLIILNDVTNKIVIKTKTQAFPLVWASWLMGQQLDQFQEYEDIDPREWVKDWIKSGLNLSFGVLSQQYVIKRMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0W5</accession>
    <name>G3B0W5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113590</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0W5"/>
    <dbReference type="STRING" id="590646.G3B0W5"/>
    <dbReference type="HOGENOM" id="CLU_3068481_0_0_1"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="53" mass="6623" checksum="3381CDB290750DFF" modified="2011-11-16" version="1">MSRIRKIKERLKFNYLGEFEKLILRVWESDNQENHSVNWAKIRYFQYPGLVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B161</accession>
    <name>G3B161_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113645</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B161"/>
    <dbReference type="HOGENOM" id="CLU_1602471_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833530" evidence="1">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="166" mass="18823" checksum="437599183990A00B" modified="2011-11-16" version="1" fragment="single">MFLIFPFLLFVSLININAFATDTINKVATNCTDYHAAVNDTVFGSAVYEIWLKSLMNRVGGKGGWSFKHNDNDLVTFHSDESYWEIKVPGSPTEQPWNLEGVLGTFLDNHNNICYIYCVRIDHSGNWIAYVKMHYPNQDNGLKELGCTSVIHFTPACGRRVRKNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B170</accession>
    <name>G3B170_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113654</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in 20S proteasome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 20S proteasome chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685700.1">
        <property type="nucleotide sequence ID" value="XM_006685637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B170"/>
    <dbReference type="STRING" id="590646.G3B170"/>
    <dbReference type="GeneID" id="18247069"/>
    <dbReference type="KEGG" id="cten:18247069"/>
    <dbReference type="eggNOG" id="KOG3112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062640_2_1_1"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="252" mass="27969" checksum="FEFCD4E1EB6F3F5F" modified="2011-11-16" version="1">MAYVKKTYRDLEVVRGTTLVVPSVSIGNVPQLATDLLIHNLAFERIAHLKDTYLYPFASPVDYATGTSIDGATTGAGISTALEVFYSAKFNLTLLQQRSPIITTFTDKFIKEIITPFVNDNEFAGVLMLDSGDSGLRESIVQGTVETYTNEDLLSKSIESLKLNDSIKSLRDVEYVNSKYIKNLSGSLGTDWLNVLVIYVYEGENFMEANILAQKVVDKLEIKVEEWVKPVSWKGVYGDKPVPVAMEEGIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B192</accession>
    <name>G3B192_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Helicase SWR1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Helicase swr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTEDRAFT_121082</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B192"/>
    <dbReference type="eggNOG" id="KOG0391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_24_4_1"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000655">
        <property type="entry name" value="Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="22">
        <location>
            <begin position="370"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="759"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="1300"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="495"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1491"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV64910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1557" mass="178206" checksum="EFC8E4B500F1482D" modified="2011-11-16" version="1">MSSSKRRSSSRLQSSSSDDFSPVPVAGKKKGKTPNNKRRKVTSQRQTSNKLVDFITDYNLAVNELFQLEEYGSIVEWQPEDFASYQKEKPQLLEYFLSENKIGLSWLENEEDNLSLDDLPLRLQKKKLAEREQKVLEKYPFRNDVLEEARASEEYIIRLVSNVVEEPVEPAAKANNIKPEKLKKSKVKIEKGDVWEIKQEEEILTEVEYPSDLDEVDTHYKLKDVKFSIPPPKITHPSHIPLWKPPKGDNIEDAEDQEIIEFNPIPIEVISTKGKLIVAPEVEHKLRDFLETKVKTAIIDETLNVDYGNTAEEYNAVLEQQKKLLKVIYRKVTEENSFELNGEKIEKRKLTLPQTNFRQLADPFRSTGSIIAKAQGPTNTTHIDNLLLQGASFAKIHQSVRKQRQLRVRKIATMVDQHFKWKRGEKERIEREREQNLKKISRLAMQAVKKRWSQAGKVYKYLQDQKEEELKKIKGREHLSNMLEHSTQLLEAQLNRPSQANTDDDSDNDSGSDSNDNEKADDTMDDQLSVSELREKYGNMSELSAEDMTNASSVSEDEEDTISSQDGSDDDDELGGSGLAALYGGVSNVQKEVSESPMPDSEYTPEQLAVINAAEKEENGNGKMVIYSDSDSSIPDETTDDSERESDAMSQDEDGSSEEEVEENGLASLLTNTENTRDSDDESVSESVGENSDDDRLSSTDEEDEPKTPKSDPETFSKTEKEELHEEIVNGSKVRDVPIPSLLRGNLRPYQKQGLNWLAGLYSNDTNGILADEMGLGKTIQTISLLSHLATEYHIWGPHLIIVPTSVMLNWEMEFKKFAPGFKVLTYYGSPQQRAQKRKGWNKPDAFHVCITSYQLVVHDHQSFKRRRWRYMILDEAHNIKNFRSNRWKALLNFNTENRLLLTGTPLQNNLMELWSLLYFLMPSSKVNQAMPDGFANLEDFQTWFGKPVDSIMEKANAATGDIIDENQSTVKGMDEETRNTVKRLHQVLRPYILRRLKKDVEKQMPGKYEHIVYCRLSQRQRFLYDDFMSRAKTKETLASGNFLSIINCLMQLRKVCNHPDLFEVRPVVTSFAVEKSVPGEYLSTDTAVRKLSEASDIFSKISYEVLNLNITANEDTNYFVSQIINELRSTNSIRKQIQQLDDLINIKSEIENEDSCLDYYTELKRAQQKSLKEQLEQAVYLNELRCSRNPIYGESLLAFLKGATDTKIPDDSILSKMMINIEQRVQGMSKEIEEFSVLTPKVVSLDMKEHYFPPEVRDRISHEVAENRLDNPFHNSQMKLSIAFPDKSLLQYDCGKLQMLDKLLQQLTSGGHRALIFTQMTKVLDILEQFLNIHGYRYMRLDGSTKIEDRQLLTEKFNRDDKIPVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQSRDVHIYRFVSEHTIESNILKKANQKRQLDNVVIQEGDFTTDYLGKFSVRDLVTNSEIAAELPELPDKPLADGNIESALMQAEDEDDRKAASAAMRETAVDDEDFNEEIPGPDAAKKEGAGEDVDFDEGVRHVDEYMLRFIANGYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1C6</accession>
    <name>G3B1C6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113684</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1C6"/>
    <dbReference type="STRING" id="590646.G3B1C6"/>
    <dbReference type="GeneID" id="18247083"/>
    <dbReference type="KEGG" id="cten:18247083"/>
    <dbReference type="eggNOG" id="ENOG502S551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016851_1_0_1"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="616" mass="68172" checksum="E6CA5DC510BF38EA" modified="2011-11-16" version="1">MDFYQPTLLFRQNAIRRSPESSQSSLDLVEYKTRNPSWIFDPNTSRDTKILNKICSLDRLNIKSNYWKIPDNNMNLTAMAIKTNDNNGTLAISSANDNSNLFIYEVDLQDAYLKHHNTISLPNIHAMKWVPGTSNLLVTGNSKGYGHLISVPEPGNQTSAEIVKRFNHRKHLRSINKDSSILHQSSSKIDKMAFNSNRSLISIYDNNLFNWDVNDCTAAARPKPVSITSINGLANFDTSPNANVLGICGRFGVSIFDLRDPQFSVPRAVENECKKTKLGSNLIKWSDDEYIFAASHLDGVIRLWDVRKQDCFGTLNAQHGSSVSSMQWVDGDLFSGGRNGHIIHWDLTSDITDYDYDLQRCGVKEGLNSVQFDPVANQADDIAGQRSCGTILPASNTSIISLETVETVDDLKVLSIDGSSFFGLHSRIYDAVDVQYRSQKLYYTHDDLVMMGERSDETLVNDTGSIHSLEKPLAITRKNTTASSAKSISRNNSISVVRNTSMASHKSITSIRSTNSVAEIEVPTGSTDTLLNMPIETAELDVDFKFGPASRSNSQSSSSVVMSPESLNSFAASFDSVATTVDEQPVPEASTHKYTLSDIQFDDDLSFGINSSYLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1G2</accession>
    <name>G3B1G2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_121213</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1G2"/>
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    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="term" value="P:mitochondrion organization"/>
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        <property type="term" value="P:signal transduction"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EF_hand_assoc_1"/>
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        <property type="entry name" value="EF_hand_assoc_2"/>
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        <property type="entry name" value="EF_hand_dom"/>
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        <property type="entry name" value="Miro"/>
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        <property type="entry name" value="MIRO_dom"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
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    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="3"/>
            <end position="194"/>
        </location>
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    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="334"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="451"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV64966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="663" mass="75327" checksum="EA5BEEAB9DB209C3" modified="2011-11-16" version="1">MSQESIRVIVCGDDNVGKSTLISALVKGEYIPNIQKKLPPITISNEDYSECLIELISNSPVKGSSRNSITDKRVSKYIPHTTVLIDTMSSDLVGLQKELKRGDVIWLVYSDHYTYERISLHWMPMLRSLGVNLPVVLCANKCDTTLGDDTSQNSDEFLPLLNEFKEIEACVRSSAKQNINVVEAFYMCQRAITHPISPIFDSKEGNLKPAAVAALKRVFFLCDKDQDGYLNYQEFSSLHTKAFERTADITEYENILRTLDRVIFPETEQDGLHPGISEDGFILLNKIYAERGRHETIWGILRSFSYTNSLSLDDKFLFPKIDVNPDSSVELSPLGYRFMVDLFVKFDKDNDGGLSENELSSLFYPTPGIPKLWRDCQFPSSIVCNESGYVTLQGWLAQWNLTTFLDYRTTLEYLSYLGFDEGSSIKALQITKPRKRRKKQNKVYRQPVFDRNVFNCFIIGAPKSGKTSLLESFLKGNYSEMYSPTIQPRICAKDIELRGGKQCYLILEELGELESAILENKSRLDQCDAICFTYDSSDPNSFQYLIDLRLKYEDTLDEVPCVFAALKADLDKQQQRGDIQPEIYTRDLSINSPLHISSNWATSLNELFIQIVDAATMPSTATAGLEKEPENINDEKYKHIVLAGGTISIMTLVSLWIWRNHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1G4</accession>
    <name>G3B1G4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="6">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRT1</name>
        <name evidence="9" type="ORF">CANTEDRAFT_113712</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685996.1">
        <property type="nucleotide sequence ID" value="XM_006685933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1G4"/>
    <dbReference type="STRING" id="590646.G3B1G4"/>
    <dbReference type="GeneID" id="18247094"/>
    <dbReference type="KEGG" id="cten:18247094"/>
    <dbReference type="eggNOG" id="KOG2314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011152_4_0_1"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="717" mass="82456" checksum="0E08E3A4BB278044" modified="2011-11-16" version="1">MVHGYTYEDLEKEINVDDVDYTDLEARYQVNQDFGLDNYVVIDGAPVTTEAKVPVLSKVLKKLLSSYGELEDGDDGFYMPIEDGKTKGYLFAQFKEADSAKKAIRQLNGKQLDKSHRLLVNSLSDIENYGSEGNVPEEFVEPEIPEFKEHGFLKDWLLDEQGRDQLLLHQSETVGIYWNKKKSDPEKVIEPRQGFTSKYAKFSPKGTYLCSIHPQGVQSWGGPEFESLSKYIHNQVRLIDFSPNENYLVTLSPLPITMPETAAERAHFPFKEENEGHKLVIWDIKTGEPARSFALPPHLEGQKEMPWPLVKWSHDDKYCARQGPNALAIYETPSFQLLNKKLVQIDSIVDFEWAPASVKLANSKVEGGEYLLSYWTPESSNQTARVALMQIPSTQVLRTTNLFQVSDCKMHWHDEGKYLCVKVDRHTKSGKTVFSNLEFFKTTEKDIPVEKLELKEVVVNFAWEPKTERFITISRLDDGTNNPAIPKNIISFYAPELSQKTKITSSSYKCYDTIEKKYSNTIFWSPKGRFAVVATIGKSNGEIEFYDCSYDDDKKPGNNKDVNKAKLLKAEKYGGMTNLSWDPSGRFVAAWSSAWIHTIENGYKLFEFTGNMLRDDTKDQFKEFIWRPRPASLLSAADRKRVRKNLREYSAQFDEADAMEADTATREAILNRRRLLEEWRDYRSKYAKVESTENEVQAEIIEEIKEEIIEEKEEVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Q0</accession>
    <name>G3B1Q0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_103766</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Q0"/>
    <dbReference type="GeneID" id="18245654"/>
    <dbReference type="KEGG" id="cten:18245654"/>
    <dbReference type="eggNOG" id="KOG2338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034867_0_0_1"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="104"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="505" mass="58128" checksum="FCC7E7DB7AEED5E2" modified="2011-11-16" version="1">MASTPAGEPSIPAYDAITSDGVSKKQKMKGKKKSMDPSKLTPEYIEEQRRLRNIKKEQKKQQLIAQGYNPEQLETNEALRYKTREFVSVGSNSEVGENFKVKIMTYNILAQALIRRKLFPTSGNALKWSTRSQVLLSEMKHYDADILCLQELDFIQYNSFWKQELSNLGYNSKFNRGGSKNHGVCIFFKNDIFVFKHQSFIDYDREESGTIFPRTITQNVGLLACLEFTPKIRSQYKLSRNGIIIGTTHLFWHPFGTYERTRQTYLVLKKTKEFVHTMNVVKENDLGWYTFFAGDFNSQPFDTPYLSVTSKPVHYSSRAKTVISCSLSFQYSKNRGIKESEAEKNSEDEEEGGNIEKFGKDQPRDPVPESFVATEEQLQLVNAMENLHNNLDVRAISLYSVAYKHVDPKNAGADNERNEPMYSNWAHSWRGLLDYIFVISSWDLSEDYSKKIDSIDELANTENIRLTKLLRLPRGEEMGEEPSGQPRLGQYPSDHFCLMAEVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Q9</accession>
    <name>G3B1Q9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_113276</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Q9"/>
    <dbReference type="STRING" id="590646.G3B1Q9"/>
    <dbReference type="GeneID" id="18246877"/>
    <dbReference type="KEGG" id="cten:18246877"/>
    <dbReference type="eggNOG" id="KOG2882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_0_0_1"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="309" mass="34399" checksum="5C5A5DD5FA3B9A7C" modified="2011-11-16" version="1">MVSSKITQKDQVKHLLDSYDYFLFDCDGVLWLGDHILPYVKETLTLLKQQNKSVIFVTNNSTKSREEYLKKFEKLGIEGITKDDVFGSSYATAIYVNKILKLPTDQKIWILGEKGIEEELQELGYTTLGGSDPELTKDGVEFHNDHPLLTNLDENVGCVVAGLALTVNYLKLSITMQYLLAKNKSIPFIATNIDSTFPSKGKLLIGAGSIIETVSFATDRKPDAICGKPNQSMMNSIKADNPGLLRTPKRGLMIGDRLNTDMKFGRLGGLDTLLVLTGIETEERVLSQPDDEAPTYYMSKLGDVYELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Z7</accession>
    <name>G3B1Z7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113333</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Z7"/>
    <dbReference type="STRING" id="590646.G3B1Z7"/>
    <dbReference type="eggNOG" id="ENOG502SC8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125054_0_2_1"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="127" mass="14356" checksum="AE8079F74F41C20D" modified="2011-11-16" version="1">MSLLTRTRLSLQAWEATRYAAGNVRCVSSTPTPVRLRFFTKDNCMLCHTAKQTMNNAVDATMAPVTVEIVDITHHDNTEWWDKYCYDIPVLHVEGGAKSVIFMHKLFKNKILEAIDEVQNGSNSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>G3B274</accession>
    <name>G3B274_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_120341</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B274"/>
    <dbReference type="eggNOG" id="KOG0386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_15_3_1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140008">
        <property type="term" value="F:histone H4 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000843">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="13">
        <location>
            <begin position="342"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="520"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="831"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="1204"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1168"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1287" mass="148657" checksum="305669AB73C7BD7E" modified="2011-11-16" version="1">MNGNQYHTAAPSNGASNGSVETTHGNGSGSKVPDVAPAKAYHFPKSKQELNHLLNEYQYLSKQSNELKQQFEQQAQDNGEDLKPSTFVDANKESKLKIESLLFQVSQKYDSFTKEKSDFFDGLLEMNQKSVDDSDLDKDLLMRQITSLQLLSKDLDLPQTLQQHLQESIGESDSEEIELASTVFEELFSSKYEYSDYVAKLLRLGIDVSESSRSTDSLGPAYDKLGGFYPEHLVSAKISNRIQDLENVPLNLGTLKFGEVDASKHYDELKIKSLIELKALKLLAKQKQLKKFLVNYQANEAHTKLESLKNDPLINQSIRSFYIRSKIEVSNPESLAIKLEERRKADLEKEQHKFRLQKIQRTIETIDEFNGERNSRFNKRQTFIKAISSFHSFIEKDETRKSERIARQRLQALKDDDVEGYMQLLDEAKDHRITHLLKQTNQFLDTLAQAVKSQQIESGVEIPLEAGAEKPTSDDADDLREKIDYYQVAHRIKEEVKVQPSILVGGSLKEYQVKGLQWMVSLYNNKLNGILADEMGLGKTIQSISLVTYLIEKKHEDKFLVIVPLSTITNWTLEFEKWAPSVKIIVYKGSQNQRREMQPEVRAGNFQVILTTYEYIIRERPILSKFEYSHMIIDEGHRMKNADSKLSITLRTYYKTKNRLILTGTPLQNNLPELWALLNFVLPRIFNSAKSFDEWFNTPFANTGTQEKIELTEEESLLVIRRLHKVLRPFLLRRLKKDVEKDLPDKVEKVLKCNLSGLQYILYEQMLKHNALFVGAGVGSNKSGIKGLNNKIMQLRKICNHPFVFEEVEAVLNSSRLTNDLIWRTSGKFEMLDRILPKFLATGHRVLMFFQMTQVMDIMEDFLRWREMKFLRLDGSTKAEDRQDMLKEFNAPNSEYFCFLLSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITNDSVEEVILERAHQKLDIDGKVIQAGKFDNKSTAEEQEEFLKRLLEAEGSGEETEEKNMLDDDELNDVLARSDPEKEIFAKMDIDRMTRDKMNGIQTRLIQAAELPKIFTEDVSHHFEKDTKELSKMRVKKRVRYDDGLTEEQWLMAMDDDNDSVEAAIRRKEMRASKRRRKKLNGVYGLDDDEDEGEDDEDEDGEYETSRRKSRRSATPNSFKEEDENIADEDEEDEVENALQIEGNRILEQLDDLVAEDGHKVTEVFEKLPSRKLYPDYYKIIPKPVSINQISKNLKSNKYFDISEMKQDLLTMCSNAKTYNEEGSWIYTDADTIEQVVNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2M2</accession>
    <name>G3B2M2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_92951</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2M2"/>
    <dbReference type="STRING" id="590646.G3B2M2"/>
    <dbReference type="GeneID" id="18250240"/>
    <dbReference type="KEGG" id="cten:18250240"/>
    <dbReference type="eggNOG" id="KOG3418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067359_0_1_1"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="139" mass="15751" checksum="693A790C087088C7" modified="2011-11-16" version="1">MAKLSKVIQAGRVAIVVRGRFAGKKVVIVKHHDEGTKAHAFPHAIVAGIERYPLKVTKNLGAKKTAKRSKVKPFIKAINYNHLMPTRYSFDIESFKSAVTTEALEEPSQREEAKKVVKKALEERYQAGENKWFFAKLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2S8</accession>
    <name>G3B2S8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_120700</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685560.1">
        <property type="nucleotide sequence ID" value="XM_006685497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2S8"/>
    <dbReference type="GeneID" id="18248796"/>
    <dbReference type="KEGG" id="cten:18248796"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="38"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="595" mass="63956" checksum="7D0261A003FA5EAF" modified="2011-11-16" version="1">MSDLEENVPVIKKFVENDAGDGTRREDQYLTGRKLVIALLSVLSCMFLVGLDQTIVTTILTQVGNKFDAFSKIGWLVSGFMVPIAVFAANWGQASIIFGRKYTMLVGIVLFEAGSLLCALATGMNMLIGGRVLAGFGAGCIQTLVFIVSSEMTPINLRPFVFASFGLVMAVSLVSGPIIGGAFASSVSWRWCFYVNLPIGGLAGLMFSLTFNPPPPKIELRSKFKLIDYTGTLLIAAGVVLFLVGVTFTSTGQYPWDSAAVISMVVLGSLFFISFFVWSFKFSHHPLIPFDLVKVLPLTAAGFCMFFMFMTFMGSLLYQSVYYQNIKGRDALHSGLSTLTIVIPMIMGSVGGGIAIGRTRHIKPFLVSASAIVLVGSGLLTLVEVDSSLGQLIGYNIPFSMGCGLLLQGCLSSSQVVAPKIDGGIIMASSFMLFMRSIGAALASILCDIIYHSSFNTKLQPALNALTDKSLIDELSAFDFASLSSNTGSLATLSPKALLVVRKVMMNSIRNVYYFVCGTAALALIFGVFTSNRRVPSKDEVVTKKERDAQDRAALELANKSDNALEASDLSSRISTTERDSGSVTTTKELNTEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2X3</accession>
    <name>G3B2X3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113558</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2X3"/>
    <dbReference type="eggNOG" id="ENOG502QU2F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1115629_0_0_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27205" checksum="FA3D67DD19A92B77" modified="2011-11-16" version="1">MVICTLVGVPGFLAVWSGDLTVGDENGSMAFFILLAKMPGWIIAFVLIFTITICTCTFDSLQSAFVSTISNDIFRNRFKTIWARAMVVIMIVPIVVLAVKVADNILQIYLIADLISSSIIPIIFLGLSDRFFWFLTGVDVMVGGLGALVAIFIFGTVYYGTAKEGGKLLLIWNGLYDPEDWGAFGAFEIAPFGGILIALVCVVARVGAIWVYCKITKKPFRALQRPVPVEIVEEEFDSAYGSTNAKSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Q6</accession>
    <name>G3B3Q6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_114277</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573</strain>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Q6"/>
    <dbReference type="STRING" id="590646.G3B3Q6"/>
    <dbReference type="GeneID" id="18247351"/>
    <dbReference type="KEGG" id="cten:18247351"/>
    <dbReference type="eggNOG" id="ENOG502SBWQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142427_2_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV64430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="84" mass="9596" checksum="8DF328936C227FA2" modified="2011-11-16" version="1">MSDFEKYRDTLIQEISNSINSIVLNLNTLNRSLHNSIQVSKEFDNVSDLWANFYSGLKKESGQQEPEEENEVEGQQDTQGSQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3S4</accession>
    <name>G3B3S4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113743</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3S4"/>
    <dbReference type="HOGENOM" id="CLU_041160_0_0_1"/>
    <dbReference type="OrthoDB" id="4022842at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442714" evidence="2">
        <location>
            <begin position="18"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="514" mass="59534" checksum="5DFD3057C022ED09" modified="2011-11-16" version="1">MKWIILVFSLFINSVSARYGAYISLHKNEEWGQTSDCFTVQGGKSAYIQIEISKFELLDLSKIRYSEPSEKLPEPSEKLPEPSEYKLPTLMYYMSDREKFQDFPNYDSDFPEGGTFNTTLKEPGSLDSSRYVNSFLSTDKTSSNFQLRLEAPQTGKYCVFMHSPETIGFEAPIEIRHEYGYLEFSHYQEYLQDRRAYFALLALVIVCMVDMTVFAGFKLSKPSKLSIITRSVVALILLPYLFLQGTSLIFDSWLNIQDNGNSGLVFVSKEFIQWLKKSFLIVTDFYVLVFCLGYGTIYYHIPTKKYQQLSLTDVKVGLAIMVARLFMFFIDASADAYSMAVHTKILDDYPDLYENDHIGTLLGYSYDLIRILGECSILLSIIYALRTRKSFFEFIPDVSMKEKYGVRNIKIMRLFIATVLIVWLLPLLLHVYNDMAINRLHNKFYPRPAKGSHFHIDFYDSTRAKRWMLDIAIAKVETWTKAAGRLTFTILFYVFWVRPNRGLVSDEVEYSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3U9</accession>
    <name>G3B3U9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_113774</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3U9"/>
    <dbReference type="STRING" id="590646.G3B3U9"/>
    <dbReference type="MEROPS" id="M67.A01"/>
    <dbReference type="GeneID" id="18247116"/>
    <dbReference type="KEGG" id="cten:18247116"/>
    <dbReference type="eggNOG" id="KOG1554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665638_0_0_1"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000203">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0736">Signalosome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="15">
        <location>
            <begin position="52"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="413" mass="46285" checksum="A37C3E1B3ED7E178" modified="2011-11-16" version="1">MTHLQELSKYFKVDTSSSVSVADGDFYHSVAGDSKAMAKRPWKKDPKYFTKTAISTLAVFKMAQHAALGGDIEIMGSLIGKIHAGCIIVTDVYAIPVEGTETRVNAQLEGYEYMVSYLQLNNKLRPNENIVGWYHSHPGYGCWLSGIDVSTQSLNQIQDPYLAIVIDPFKSIKQGKIELGAFRTYPDDFKTDPSGVTTEKRARFGNHADSYYSLDIEIYRTTADEELVRFMNKETWVQELVVKPEVAESHEASKMDAITKATRLVCHAGHEGRMSMEGEGTEKITSQMNSHRRLATQFNGLFVKSAEAEASNHLNPYNAASKHRITSPVPPPSTIPEDDMMEDDVLSSVDVNYDDLDDDTSNDEASIYTKPRKFRRRIAGNKDLALLADGCNRLGTHEVRELIVQDIQRKLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3X4</accession>
    <name>G3B3X4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oleate-induced peroxisomal protein POX18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_93393</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686199.1">
        <property type="nucleotide sequence ID" value="XM_006686136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3X4"/>
    <dbReference type="STRING" id="590646.G3B3X4"/>
    <dbReference type="GeneID" id="18250287"/>
    <dbReference type="KEGG" id="cten:18250287"/>
    <dbReference type="eggNOG" id="KOG4170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105945_0_2_1"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="129" mass="14537" checksum="FBF3F00B7AE618F3" modified="2011-11-16" version="1">MSSLSEPGFEGTELLDFMKSVLDDDEKLRAKSIKQAKANVILTLKNKDKETKSWFFEFKNTGEVRKIDGTPPKADVALFMADKDFLKLVNNEANPQKLYMSGKLKIKGNLMKAVSLEKILRAADPRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B451</accession>
    <name>G3B451_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_113820</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B451"/>
    <dbReference type="STRING" id="590646.G3B451"/>
    <dbReference type="eggNOG" id="KOG0880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006524889" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="213" mass="23427" checksum="0A206FECE1F8D34B" modified="2011-11-16" version="1">MMKIISVLIVSICFFFYSIGGARAADLPEDPPVTDKVFFEVTEDGQSIGKITIGLFGTVTPKTVKNFKELTLSTDPSFGYTGSIFHRIIPKFMIQGGDYETGKGYGGKSIYGGKFDDENFILKHDRPYRLSMANSGKNTNGSQFFLTTVVTSWLNGAHVVFGKVVDGFDVVDYMEKVKTSYGDKPVKELKISATGEVPLTGEEEEALLVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B472</accession>
    <name>G3B472_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_113832</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573</strain>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B472"/>
    <dbReference type="STRING" id="590646.G3B472"/>
    <dbReference type="GeneID" id="18247138"/>
    <dbReference type="KEGG" id="cten:18247138"/>
    <dbReference type="eggNOG" id="KOG0559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_1_1"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="61"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="438" mass="47811" checksum="89DDD0310FF0E32A" modified="2011-11-16" version="1">MLSRNLKCQARRLPLIGRSVIKSEVALVRSFHVLNVKPVASSAGFKHQPINTITNFKRLASTSIKVPEMAESITEGTLSSFNKQVGDYVNQDELVATIETDKIDVEVNAPVSGTITELLVSEEDTVEVGQVIVTIEEGAAPEGAAPSAPKEDAPKDEAPKEAAPKEDAPKKAEPAKSAPPPQPKKEAPKKTETKESSSATFTNFSRDEERVKMNRMRLRIAERLKESQNTAASLTTFNEVDMSALMEMRKLYKDEFLDKTGIKFGFMGAFAKASTLAMKDIPTVNAAIENNDTLVFRDYTDISIAVATPKGLVTPVLRNAESLSILGIEQEISSLGKKARDGKLTIEDMTGGTFTISNGGVFGSLYGTPIINMPQTAVLGLHGVKERPVTVKGQVVSRPMMYLALTYDHRVLDGREAVTFLKTVKELIEDPRKMLLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4C2</accession>
    <name>G3B4C2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113972</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4C2"/>
    <dbReference type="STRING" id="590646.G3B4C2"/>
    <dbReference type="GeneID" id="18247200"/>
    <dbReference type="KEGG" id="cten:18247200"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071097_1_0_1"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="223" mass="25619" checksum="085CE008AEC4626C" modified="2011-11-16" version="1">MWNYFFGGNPSQKKELPKKAIVELREHIQMLNKKRSHLEQQINDQDSLARKYISTNKTLAKNALKRKKGYETNLMKIENQIDTLETQLTAIEGANLNLETMKAMKQGATAMKQIHGEYDIDKVETTMDDIREQVELADEISEAISRPVGNDYVDEDELDEELAMLQQEQEQEKQAVKPQAQKQAPVREETLPDFPTVNKTKPQVEEEDEDEEALKALQAEMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4H2</accession>
    <name>G3B4H2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sec63-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_121553</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B4H2"/>
    <dbReference type="GeneID" id="18248856"/>
    <dbReference type="KEGG" id="cten:18248856"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_2_0_1"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000241">
        <property type="entry name" value="Antiviral helicase SLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="251"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="510"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1109"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1321"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1913" mass="216542" checksum="FDB5D0E3323DB757" modified="2011-11-16" version="1">MMETLDSLEIPQTTKIPAMDNEQEKTSSIDKILQKFSNLDTDIVNRVQDVLSSKSSVVNEIRKECDRLAEANHNENLFESVKNLLIASNSEEEIQSSLFDILGFEEIDLISKIVQNKDVIIEATDEETDDSTSGKFMTPEERIQFLVENQERLKHQKLAPRQSGNQYPHVFKKEDVSQFLAVLGKNVALPTGSLRTSHPAYEELVIPYPEQHANKWISDSQLVQIKDLDFLCRGTFSHYDTLNKMQSLVYPVAYNTNENMLVCAPTGAGKTDVAMLAILHAIDQYTSETVDEEGNISVDIDYQEFKIVYVAPLKALAAEIVEKYSEKLKWLGITVRELTGDMQLTRLEMMTTQIIVTTPEKWDVVTRKSGGDNELVTKVRLLIIDEVHLLHEDRGSVIETLVARTLRQVESTQLMIRIVGLSATLPNYVDVADFLGVNRNIGMFYFDQTFRPVPLKQDLIGVRGKAGSKTARDNLDIVSYEKLAECVKQGLQAMVFVHQRRETVNSANGFISNAYNYHESAIFDCSDSPSYEKFKREVGNKNRSKDVKDLFQHGFGVHHAGMLRSDRNLTEKMFASGAIKVLCCTSTLAWGVNLPAAVVIIKGTQVYDAKQGGYTDLGISDVLQIFGRAGRPQYESFGTGVLCTTSDKLDHYISLISQQHPIESKLSAKLVDNLNAEISLGTVTNIEEGIQWLGYTYMMVRMRKNPFAYSIDWKELQEDPLLYNRRRKMIVSAATRLHGLQMIIFGDVSGSFIPKDLGRIASDFYLLNNSIEVFNQMLNPRATEADVLSIISMSSEFDSVKYREDEKKELERLKEDAVQCQIPGEVEASQTKTNILLQAFISKTMIKESSLIADTNYVAQNAARICRALFLIGINRRWSGFSKVLLSLCKSIDKRIWEYDHPMAQFELPESVLKNLRAINPSIETLRDMDSAELGDLVHNNKMGSTLYKLVDRFPYIDIDTEIFPISSNVMRVHVFLDADFRWDPNHHGSAQYFWVFVEESTNSDLLHVERLIINKKQLHGHEMDFMIPLSDPLPAQIIVRVISDTWLGSETVHAISFQHLIRPNNETVRTNLLRLQPLPITALHDKKVEAIYEHKFKYFNPMQTMTFFSLYNTNTNVFVGSPTGSGKTVVAELAIWHAFRDFPGSKIVYIAPMKALVRERVDDWRARISKNSSHKVVELTGDSLPEAREIRESDIIITTPEKFDGISRNWQTRTFVQNVSLVIMDEIHLLASDRGPILEMIVSRMNYIASQTKNPIRLLGMSTAVSNAIDMAGWLGVREGLFNFPSSVRPVPLQMYIDGFPDNLAFSPLMKTMNKPAFMAIKQHSPTKPVLIFVASRRQTRLTALDLIHLCGMEDNPRRFLKMTEDELQDVLENVKDDTLKLSLQFGMGLHHAGLVESDRRISHKLFESGKLQILIATSTLAWGVNLPAHLVIIKGTQFFDSKIEGYRDMDLTDILQMMGRAGRPAFDTSGTAIVYTKESKKMFYKHFLNIGFPVESSLHKVLDNHIGAEISTGTIKTRQEAMNFLTWTFLYRRAHNNPTYYGIEDSSTAGISSFLGSLIDQTIDNLMESKCVIAKGKDGLAATPFLDISSYYYLSHKTIRKIVYGINNAFEIRDCLKMLASAVEYDELATRHGEELMNMEMSQTMRYPAEDMECDFIWDPHVKAYLLLQAFMSRANLPIADYSQDTIAVLDQSLRILQAFIDVASEFGYLHTVCKFIQLMQSIKQRVWYDNHPVSSLPGCRIIDGDTSKIPNLEALGTMGKAALAKVGASLSIENTPIEDVRKYGASNKALDQFIHVASHLPVCDFSVNQKNSEQVEVVLDHKNYPLDSKFVTYCPHFPKSQRESWFIILCNSEKTELLMINRASPRMVGRKGKVSCTIEVPEDVQGKEVIILCVNDGLDLQYEKKLTLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4R5</accession>
    <name>G3B4R5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113880</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4R5"/>
    <dbReference type="STRING" id="590646.G3B4R5"/>
    <dbReference type="GeneID" id="18247159"/>
    <dbReference type="KEGG" id="cten:18247159"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021528_0_0_1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="378"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="569" mass="62939" checksum="7BA09BA8D9BD4023" modified="2011-11-16" version="1">MSEYGENNIYSLMDNDSTTNQIWKLYNKAKDSLPYRTRMENLTWRMMHINSQKHKLKPILDPSADDFDYIAHIKKMGQESSEYSQILRFGSHLEFPSSAMSDSMETDNIVSSNTHPISHHRPSHSFQGSQSAKGLHNFNSNHMHDTPHDQMNSFAPDSAHPSQWMDNGHLQETTTHTPDFNNFHNPLHSDFSSSMPSHDHALGHQNLNLIQSQTLEFDDFDLGPDFKDLELELHSHQNSIVNLSELNPGRGAPSLQHTSSLANIHDQQAKKLRAIPVKPSSSSAHQSPTHPMSSSLPNTSSLTKFHSPLHFDDLNYFDNFNKEQKFDMNSSLKPKAKRTKTKKLKSVSPDSSTANNGSSNGASNGMGSANRSSNADLSNQNVSCTNCHTKTTPLWRRNPEGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRQRNSNSSKKITVRDGDDLNPTSVIGGVGGPPAPQTQGERDKKSPRKRRPVNIPNTPANAGIASGANSANIAQSNTSSMSASSFGLGMNMHTPNTNSSTPASSGMKKEEDLHPINEMDDAYLNSEYVPDDNLDWLSMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4W3</accession>
    <name>G3B4W3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_134576</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4W3"/>
    <dbReference type="eggNOG" id="ENOG502RIW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466213_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF14">
        <property type="entry name" value="ZINC FINGER PROTEIN GRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="598" mass="67637" checksum="7DF68C7D8AB0E6B1" modified="2011-11-16" version="1">MEQLKKRRTRVLRACENCRQRKRKCSGKVVCSECAKYGDVCVIRSHFSAASSISTPQSDSKEQLEIPDYLSVRGQNDAPEYFGPASNYSFVNQLNRVLQQLDNSNDDENKGLDRFGMGPSVLDQSNTDFSVDEISTDTMNRLLVAFLETWSVTCPIFEAPQLFNLASHTWKSPSSTPNDRALLYLVLALGASTSYFDVDESNADVFPLARGFFNLALHAVPGISSQTSFEAVRVVFLMSLCACALGDTALSYVYSGIAVRISLAIGLHKNSVVTRSPDYAHRQRVWVSIWQFEHYWSFCVGRPSSLGESVTAPEVKKEDFTYSGYGETNSFITTSEHMKLRVQFATSLTKINMELYSSKNDLLTILSKVEYFSSEIDNAYFASSDTQITQAKIEDGVEFVKIERIREWFWIRIYYLYIKLIIFRPFLIFSVYLTNTSADVSQSIRDKIKAGADTCVEVAIELSDFIIKLNKKVRMLQPVLFISSYLESTSTVLLFYTVSSLASISDVLARRIWNALQVTRSFLNGSYGYYIGSPKIMARDGLESLHEVLTKKDTDDRKTYLDKIMSAVSVSSPTPQEFQDEMGLEAFWMQTLDWISYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B518</accession>
    <name>G3B518_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_93741</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996523">
        <property type="protein sequence ID" value="EGV63715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B518"/>
    <dbReference type="eggNOG" id="ENOG502SQPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098504_0_0_1"/>
    <dbReference type="OrthoDB" id="4070698at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442732" description="PA14 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="26"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="277" mass="29967" checksum="47DBD4F41AEE2B35" modified="2011-11-16" version="1" fragment="single">MILKSITFLAFVTPVVLGISGCSPPSTESGLAVDYFDDVEHYNFSSDYLSTIDAMTPDYTKYGVSNIDFDFTGISEGDYGDVYGRQTPVDYFALRLSGYFLAPETGTYTFQITLADNQASFAFGGVTETLNCCSSPSNLQVNGSVYASLSSTTGELETTATTVYLVAGDYYPVKLIYYQAGPTAGTFELTATYPDGNSHTTDLPWYSINDTESELCTTTTTTNIWTGTDTETFTETASDGNVFVTIVVPESTTTITEPWTGTDTTTTTIYPSNLNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B524</accession>
    <name>G3B524_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_106599</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B524"/>
    <dbReference type="GeneID" id="18245902"/>
    <dbReference type="KEGG" id="cten:18245902"/>
    <dbReference type="eggNOG" id="ENOG502RQ2H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080218_0_0_1"/>
    <dbReference type="OrthoDB" id="4091843at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="298" mass="34247" checksum="0193466B42AC1126" modified="2011-11-16" version="1" fragment="single">LMSLTTNKQQELIDESINEYISTYDKVASQYLHVRKQILELASGASKNQSISPADHITIKKLQFELDTVWGSYSGYLHTLENYLDISKHIQPSYVDELSKKYEKLLVSKLSLTKTIRNIKEVQIPLIEEMKELTKVFQKNLSRTTTKRYPSKAAVENALNNRSKESMKVDNLIVSRSELHQLFDGFDEKVRQLEEGKEDTSRSIKASYYINKELESGEKFLALDDDKYLFQVSKINYQDSYLANASVAKYDELNDQLVHEIADLIAHSTSAKRSWIKNAAKIDAFKAILEEDIEMADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B572</accession>
    <name>G3B572_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_134986</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B572"/>
    <dbReference type="STRING" id="590646.G3B572"/>
    <dbReference type="GeneID" id="18249827"/>
    <dbReference type="KEGG" id="cten:18249827"/>
    <dbReference type="eggNOG" id="KOG1898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003246_0_1_1"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="23"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="364"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="723"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="111310" checksum="D6753184E3E4602D" modified="2011-11-16" version="1">MYLYNFTSKASTSSVSSIIGQFTKKQQLVIATANTLETWIQQDEKIEKVRSQFSFGIIQKLEKLRPLGFDRDLLVITSDSGNLTVCEFKHEEFVPLFHEPHSKNGLRSITPGEYLDIDPHNRAIMISAVERNKLLYRVHVENERVSLSSPLECLSNNTFTLCTCAVDNGFNNPLFAAIEIDSNKKTVLNYYELDQGLNHVMKRTEDVPESANLLIPFDGLMVCCDGFILHNGKELAFPKKSKIVNYVIHKLKNDFFVLLQNEFGDLFKVDTDQINYFGHLPVSVAINIFKNGHLYANCSNTNKLYCQITGLKVSRSTSDNLENLELVQTIESLDPILDIKLKDSHLITANSTSVKTLVHGVPTTTIVESPLPSSPLKIFTTKLTRDDVNDAYLVISSSETSVLSIGEEVAEVTDSKFSKDPTILVQQVGKMALIQVYSNGIKHINGEKVTDWFPPAGINIIKASSNNQQLIIGLTNNEVIYFEVDVDDQLVEYQDKVELPTNITALAISKDFAVAGCADETVQVISLKQQNCLEILSMQMLSSNSSAIEFSEQEVHIGMENGLFVRTNIDARGKLSNTRVKYLGTKPIRLSKINDSILAISSKPWVGFKTNGNFNIVPLNDIDITDGTSFYSEDIGGEGIVGFRGNDLIIFTIDDFRNNFIISTEDIPATKLLVDNEVYSLGKELVRNNKEKFAFEESPLSICRFKDYVVVGVTNPNFLYTFKDMKLVHKTEVEMPPRSILEFNGRLLVGMDNLLRTYDLGKKQLLRKSSTAIKHINKIIRIVYQGKDRIVVGDSNNSTIFCKFIENSFVPISDDTMNRQITSLSTLDYDTVIGGDKFGNVFVNRIKYDNTYFVEESYLNGSSGRCQTLAEFFLNDIPMSFTKGTLVLGGPEVIIYAGLQGTIGILLPISESDFKFLSNLSIELNKDLLLGRDHMKFRGYYNSTHNVIDGDIIEKFLELNASSRIKISNKLNKSVREIENKINDYREKSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5B4</accession>
    <name>G3B5B4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114495</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686969.1">
        <property type="nucleotide sequence ID" value="XM_006686906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5B4"/>
    <dbReference type="STRING" id="590646.G3B5B4"/>
    <dbReference type="GeneID" id="18247448"/>
    <dbReference type="KEGG" id="cten:18247448"/>
    <dbReference type="eggNOG" id="KOG1212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="99"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="570" mass="63387" checksum="D786D627492646FB" modified="2011-11-16" version="1">MSADTILAQVDVTQYEDPEKFKAFIPKLEKYRQALNDAILPQYSVELPDKVENLTAKQFNPVKYLYSQKLLTPSEFEITDSSAPQLVAKFATGELTAVEVFKAFAKRATIAHQFTNCALEIFTKDGLKRAEYLDDYFKKNGKLIGPLHGVPISLKEQMDFKGRQRHACFVSKIDHICEAHGTNAQILENLGAVFYIRTNQPQTLMHLCSDNNFIGVSRNPFNLSLTPGGSSSGEGALVGFGGSAIGVGTDIGGSIRAPAAYSGCHGLRPTSKRIGLAGSLSAGAGQESVMAVAGPLARTIEDIDYWMKHYINDGKPWEVDQNTLRLPWKEVAAPKASDLTIAVMYDDGIVRTTPPITRGLKETVAKLEKAGVKIVEFKPIRTQLAYDTVNSMYTCDGNDAQRELLAASGEPLCRLTKWSLNYGGGKELTVTQNRKLNMIRDSLRQEYTSFLIDNKIDFILSPTYNNVAPKPKQVYNWSYTSLFNILDFPTLVFQTGIFQDPEIDQWDASYKDYKFRSELEEIECNIYNPKEFVGAPVGLQLSGRRYFDEEVVAAGKTIVDILQVDLTKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Q0</accession>
    <name>G3B5Q0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114574</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Q0"/>
    <dbReference type="STRING" id="590646.G3B5Q0"/>
    <dbReference type="eggNOG" id="KOG2313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_2_0_1"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="109" mass="12513" checksum="A1D46E05EC05D8BA" modified="2011-11-16" version="1">MPACIVVRSHVNGPVEEKIVNKLLALNPTTLKVFNDSHKHSHHRSMQEADNTVESHFRIEIVSEEFKGKGLPNRHRIIYKLLDDEIKIDKVHALQLKTKTQEEVERASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5R4</accession>
    <name>G3B5R4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_135115</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687081.1">
        <property type="nucleotide sequence ID" value="XM_006687018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5R4"/>
    <dbReference type="STRING" id="590646.G3B5R4"/>
    <dbReference type="GeneID" id="18249845"/>
    <dbReference type="KEGG" id="cten:18249845"/>
    <dbReference type="eggNOG" id="ENOG502QYFC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483103_0_0_1"/>
    <dbReference type="OrthoDB" id="10416900at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="287"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="421"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="564" mass="66227" checksum="C82500FFD46C5016" modified="2011-11-16" version="1">MLATQRISIKLKRLGISYTQLFVVSVVLALLYSFLGTTSKIYEPQLINAIDKYSANILSYHTTDTPVDFSWIQFLDLNHFFASHKKLISPLNCEEFANRIQKGPRSFFNCRDQPDNKLVPISLQQNVNMYIDDMSRKIFGKIHLYKSFPNPSNLLYLFHDNYVKFPVKTETKFMSLKSVNLKSAASKLTSFNQDLSPKPVISLNYDDFNYKKNLETFSEESKVKELHYKYKDTKRARKYFGEAYLIDYTGAFNLDWRFFNATNVLEKDLDLKNAKISRLIRGWLNLCSKLEIPSWLTDNNLIGWHMNGLHLPFEDDFSFQITMKDILKLVDQGLNQSIIFDYSDIDKGIKSEMFLDISPYFKMRDRNNKENLVDIRLIDLETGLFLNIIGVSTFQYERLYNYQQKPVFQSLEEGDSRRIENYIKRFKDSREGLLNTKNLEVYNFDDFSSMIPVMFENQVAYLPANYMTLLTNKYFDPFAHSKKGYIYRAGINLWIPKDTCKLPPFLSIPTIEQDMQCLKIDKVNRLHKEYKKATEFHESFMESFNELSDYSGFTLKPLDFGGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5W3</accession>
    <name>G3B5W3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114614</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5W3"/>
    <dbReference type="STRING" id="590646.G3B5W3"/>
    <dbReference type="GeneID" id="18247507"/>
    <dbReference type="KEGG" id="cten:18247507"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079690_0_1_1"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="177" mass="20196" checksum="53ED90309ABA130A" modified="2011-11-16" version="1">MSLDPVVKMTMGGSSSSSEPACKISMLWNWYTIDSCFIAKSWHVRTRGMFAGSCIGVFLLVFFYQWLGRVAKEFDALTITASPKEEQYTSKDISSPLVYLVSHQWLLRRRNSSWVHHLIRSIIFTIQWGASYIIMLLFMYYNGYIIISCILGAFFGKLVFGMSEPSSTDEDVSCCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B608</accession>
    <name>G3B608_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase, V1/A1 complex, subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_123509</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B608"/>
    <dbReference type="STRING" id="590646.G3B608"/>
    <dbReference type="GeneID" id="18248959"/>
    <dbReference type="KEGG" id="cten:18248959"/>
    <dbReference type="eggNOG" id="KOG1664">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073641_0_0_1"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="226" mass="25531" checksum="7B6A08757FCD2F25" modified="2011-11-16" version="1">MSLTDDQVNAELRKMKAFIEKEAQEKAKEIKLKADEEYEIEKASIVRSETAAIDAAYEQKFKKASLAQQITKSTIANKTRLRILATKEEVLDQIFDEAKTQLNKISANKGEYKAAFVGLIEEGLFTLLEEEVTIKVREADLSLAKEVVDEVTKDFEEKAKFPIKVFVDESDFLSKDCAGGVVVINKNGKIEVNNTLDERLKLLSEEALPGLRLELFGISETRKYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B674</accession>
    <name>G3B674_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_135219</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B674"/>
    <dbReference type="HOGENOM" id="CLU_1895929_0_0_1"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="134" mass="13672" checksum="3849AAE53154B632" modified="2011-11-16" version="1">MSLLIDSTSLSTPTMSSLEDLSRVTNIALISSADQLKNQAVSSDNGLLLDESNYSMDQIGEYSSSPQTLTLESASDSILSSAADTTSSSAASSSSGNSGSLEDNSAAATLDMVTVKLYVILGSLMFATAVVGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B692</accession>
    <name>G3B692_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114719</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B692"/>
    <dbReference type="STRING" id="590646.G3B692"/>
    <dbReference type="GeneID" id="18247550"/>
    <dbReference type="KEGG" id="cten:18247550"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032220_0_0_1"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="159"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="225"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="330" mass="36622" checksum="1FA004B655FD20A5" modified="2011-11-16" version="1">MVNYSPKHSRKPSSLTSNRNINMKNLSLNLDDGSSITAGPTSGASKKALSIGISASDQPSDSQSPFLSSSPIVHNNSSTMLLDSKTSSSLKLSPVESSPRVRNNPALHTSKDYKFPHSDLTESFSKLAVSQSETHTLSFRPNVPEELQESSQLDAYPNGPANVLNGSVFLYSEPTIDEINQFDLVINVAKECPDLSAEFNKENLASKKYIYIPWNHTSSISEELPQLTRLMASYDDSDSRSRKRKILVHCQCGVSRSACVVVAYFMMKFKMNVNDAYELLKTGTSASSPEKTNRQVFERGYTIQSCDRICPNMSLIFELMDFNETLNHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6D3</accession>
    <name>G3B6D3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_123705</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6D3"/>
    <dbReference type="eggNOG" id="ENOG502RRZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029564_4_1_1"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="381" mass="42507" checksum="554DC11156C8EC85" modified="2011-11-16" version="1">MQKPSLTVWTNDNESHDDFFQYAKVDVRAPDTVADAGRSRSHTFKSTLPDDISSVGSIPPVAPTSPISNDSQNPNSPAFKRYRVAAAIFFGISITSALVIIALQAYMYAVINIHKELIPSESKFEEVSIYLALFIFAAVFQVLISAIGLRSQNMLLLGFLCVFYGCMLIYTGIQYEEVHKLVGAILVNGWKRATRATNIATICIIAATMVSQVVLIVYYLKRHVSWFRYKSIGADLLIRRMYLTFQVHRSLLVFGFFFFLAFTIQFIIIMVRDKTSVEFILTVIVIPLTIVLLVLSDLGVGRENLWLTGGCLMVYLGGIAYVLFKMIRLFTKYTSAYNVAVVPGAYFPGRSSLITFGVITLVFLVLIVVAEVVLMCEEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6P0</accession>
    <name>G3B6P0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114297</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6P0"/>
    <dbReference type="STRING" id="590646.G3B6P0"/>
    <dbReference type="eggNOG" id="KOG3013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034114_3_0_1"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000063">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="345" mass="37975" checksum="F15DAAD32F963541" modified="2011-11-16" version="1">MDVSDVISISKPSIARTNVIDSDVEMSDTETNGAEQTSIVTPGELVTDDPVWMKGHGTYFLNDNIYSSVAGNVSRVNRLLSVIPLRGKYQPETGDHVVGRITEVGNKRWKVDIGAKQDAILMLGSVNLPGGVLRRKSESDELQMRNFLKEGDLLNAEVQSVFSNGSASLHTRSLKYGKLRNGIFLTVPSRLVVKSKNHTHKLSGDVSVILGINGFIWLSKTSTSNFTNNESNIAGNRVQSAIDGQGSYNPGVGSVSITRLEEESSWEIYSDKNEFIPTTVRDTITRYYNVIRALSYGELGITDQRITMGYQASLQYANVGKLVDKDAMEQICDDVITNEKMRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6S4</accession>
    <name>G3B6S4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair and recombination protein RAD52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_93782</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6S4"/>
    <dbReference type="STRING" id="590646.G3B6S4"/>
    <dbReference type="GeneID" id="18250326"/>
    <dbReference type="KEGG" id="cten:18250326"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011431_3_2_1"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="408" mass="45538" checksum="3D7C2C80F2C1BD53" modified="2011-11-16" version="1">MPRSDANRMVGVAQYFPPNKPFEAVQFTNDQFTDIKTSLDKTLGPEYVSSRPGGGGTSVAYLEGWRALNIANEIFGFNGWSSAIVGYTLDFCDTSRDGRISMGLSVVVRVTIKDGTYHEDIGYGYIDNAKSKAAAYEKCKKEALTDGVKRCLRCFGNVLGNCLYDKALMSKLRGIPKNTTDLGENDLYRDDTFTKIRDQRQHTTKVNIMPGKEKAEYKQKVDHKQTTDKEESSAGHKQPPPTDPKEATPATKQAPGQDEFDDSFLFSDDAEMNKIDDYEMEMIMNKSDKENEEPDIDNTFHKTNAPKDAVAPPIPFEVPLFVSAKRADLLNTTPSTDIPQFDPKFVSPNIRRTLDPTRSAPVRRNDISTSQTPSKPLVPLMSTTTTPSTKRMIGMPPSRTPVKRLHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B778</accession>
    <name>G3B778_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_98783</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B778"/>
    <dbReference type="STRING" id="590646.G3B778"/>
    <dbReference type="eggNOG" id="KOG3505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_1_2_1"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="71" mass="8374" checksum="70D97D5A12C617D5" modified="2011-11-16" version="1">MAKAKTTHTMVKLVSAAKTGYQKWFNIPRHTQRLNLILYDPVAKRHCLFTEEKKRKVPLVIPKDFTRSHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B790</accession>
    <name>G3B790_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tim17-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_109615</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687766.1">
        <property type="nucleotide sequence ID" value="XM_006687703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B790"/>
    <dbReference type="STRING" id="590646.G3B790"/>
    <dbReference type="GeneID" id="18246127"/>
    <dbReference type="KEGG" id="cten:18246127"/>
    <dbReference type="eggNOG" id="ENOG502S3TP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085417_0_2_1"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22128" checksum="B35AFE0F94E45D2F" modified="2011-11-16" version="1">MSTDGISVNTIDAVDIRRNERFHMFPEERVKSIAGITGVIGFFSGFYDGIKSSSVRYLTENSHRLPRNVGGWYFYHKKKNYIMLTSGFRTGVRHGLKYSLLVSSFFSAEALVDQARGVQDFLNTTVTSSVFFTTFAYYKRLSRVQTLSYGKRGFLFGLCIGVCQDLMIWNRGGKVWYLEEWVVKRSGTQPEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B833</accession>
    <name>G3B833_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-phosphogluconolactonase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115804</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B833"/>
    <dbReference type="STRING" id="590646.G3B833"/>
    <dbReference type="KEGG" id="cten:90981711"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF24">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="259" mass="28238" checksum="51521B8DDEAEDD4A" modified="2011-11-16" version="1">MVASVYSYQDSAEVASALAKHVLKYQAKAINDSGKFRLAVSGGSLGKALKKALIDNKDVLSQVQWDKWEVYFSDERLVPLDHEDSNAGLFFSSVIDQLPSTVTKPKVITIDESLLTGKDGQVDGSDHTQDKAIAQDYEAKLPSNKKMDLVLLGCGPDGHTCSLFPGHPLLQEQTQLIAYIKDSPKPPPRRITFTFPLLQKASGLAFVAEGAGKAPILKEIFNNPNSKLPSQLVNNLDVEVAWFVNNDAINGVDVLPSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B837</accession>
    <name>G3B837_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115806</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B837"/>
    <dbReference type="STRING" id="590646.G3B837"/>
    <dbReference type="GeneID" id="18248028"/>
    <dbReference type="KEGG" id="cten:18248028"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="218" mass="24479" checksum="9FEF3D3B48E3EF6E" modified="2011-11-16" version="1">MADEEFPCPSYKVVVLGDSSVGKTSLVHRFTTDEFDTNLANTIGAAFITKLHASKTSSRNLKFEIWDTAGQERYKSLTPMYYRNSRVALVCYDLSNVDDSFVKSKYWIDQLKLNNESVSEGQINIVLVGTKSDLANKPHTTVISEFTEANPHVKHFITSAKTGEGIEAIFNSIIDNIPEDFFNAHYESLRQQAENNQKSQSISFLNNQFTGPNKSNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B865</accession>
    <name>G3B865_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_115159</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B865"/>
    <dbReference type="STRING" id="590646.G3B865"/>
    <dbReference type="GeneID" id="18247746"/>
    <dbReference type="KEGG" id="cten:18247746"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047877_2_1_1"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="317" mass="35689" checksum="E3A40829B97C4B0D" modified="2011-11-16" version="1">MYSPYGNTGGNYPQQGQYQDPSVYGNIQHPQPQHAPFQHQPQNAPNTHQQPQGGNEFYNNFFQDPASSMAAQFAKNSLGQSNDYIQQNFGAFIPPTSNLNYYFQISNSYVLRKLRLILFPFRNKNWARLASTQGAGDGTQSSISYAPPSQDINAPDLYIPFMSYITYVLLWALFQGLKGDFHPQLFGYLASQALACLIFDIFIFRVGLYLLNCVSSGSFWDIVSFSGYKYVPIIVLLILKQFIGVGFVFYGSICSLAGSFALFLMRSLRFLVLPPSNSVVGSTATNSIPASQRRLRLQFLFVYSFVVQLLVFIFMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B895</accession>
    <name>G3B895_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_94607</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687888.1">
        <property type="nucleotide sequence ID" value="XM_006687825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B895"/>
    <dbReference type="STRING" id="590646.G3B895"/>
    <dbReference type="GeneID" id="18250420"/>
    <dbReference type="KEGG" id="cten:18250420"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="29"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="525" mass="57166" checksum="96CD4BDA2B964309" modified="2011-11-16" version="1">MGLEDSKLLQKYLNFGERKAGSTSMGIFVGLFAAFGGILFGYDTGTISGIMAMKYVTERFPQDIPNEFSSSEKSLIVSILSVGTFFGALGAPFLSDTLGRRWTLIIGTLVVFNLGIVLQTAATDIPLLCAGRAIAGLGVGLISAVIPLYQSETLPKWIRGAVVSLYQWAITIGLLLAGCVIQGTHNRNDSGSYRIPIAIQFLWALILGIGMFFLPETPRFFISKSRDDEAKESLKILRKLPIDHPDLVEEFEDMKAAFEFERTLGGGGWLDVFSNKNKQLKRLITGTSIQAFQQLTGVNFIFYFGTTFFKSSGIGNEFLISLATNIVNVGMTIPGVILIEVIGRRKLLLGGSVVMSVSQLIIAIVGVTSQTKSSNNVLVAFTCIFIGAFASSWGPTCWALIGEMFPLTTRAKSVAISTASNWLWNWAIAYATPYMVDSGPGNANLGSKVFFIWGGFNLIGMAFTYLMVYETKGLTLEQVDELYEAVPNAWNSAGFVPTEHAFRNNLAESIQSDTKQEAVSENESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8H5</accession>
    <name>G3B8H5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115858</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8H5"/>
    <dbReference type="HOGENOM" id="CLU_2775715_0_0_1"/>
    <dbReference type="OrthoDB" id="10443289at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="69" mass="7905" checksum="CEE5898F5E27B101" modified="2011-11-16" version="1">MSFWKILPALALTPFHAIVSGLYAYSIKLAVDKETYEKYCEKQNESFKVIFEHFGHFDNSDSSGGKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8I0</accession>
    <name>G3B8I0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_136326</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8I0"/>
    <dbReference type="STRING" id="590646.G3B8I0"/>
    <dbReference type="GeneID" id="18249963"/>
    <dbReference type="KEGG" id="cten:18249963"/>
    <dbReference type="eggNOG" id="KOG1276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009629_1_2_1"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV62399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="541" mass="59918" checksum="5EFDE4A4C38C2683" modified="2011-11-16" version="1">MSIAQRILRKPPPNGSVGIIGAGVSGLSFAYFLTKLRPDLSVTILESGSKTGGWIQTTELQNTNSQITLEKGPRTLRGVSDGTLLILDMLVQNGYSNQIMVMKSSSVANRKYLLDSNYNIVPVPHSFGSFVKFSGSELSHGLSGSIVRDFWNRKGDSKDESVEQFFKRRFGSTLLTDRILSAILHGIYAGDISKLSVKSLFPSLQKYEQNDGSIIKPMLKSGMKYIFSREERARRTQTSLPESLKSYEQKVASSSNLTNLRVALKGHPIVAMKDTLAVYPRMITSVLQHNPKVKFMFNTKITEVCTDSGVVKIADGTSLQFDHIRSTINVNSLAKLVDSTSLADQLKSIEYVSVFMANIYSPNPNIKHKDISGFGFLVPKSARNKEYLLGTIFDSDIAGHVYPLSDEPSSNSVKSTNMTMMLGGHWYQSGIPSTELSLKAVKTTLEKVFDVDLNDFNIILRDEQRTDDKRVALTDKDIVISYNMHRNCIPQYNVGYENTKTKVHDLLNSESNRLSVGGMCFGRGVGVPDCVMNSLDDALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8J3</accession>
    <name>G3B8J3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATPase synthesis protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_124819</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8J3"/>
    <dbReference type="STRING" id="590646.G3B8J3"/>
    <dbReference type="eggNOG" id="ENOG502RGZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_454918_0_0_1"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="604" mass="69731" checksum="132CCD9108E3209B" modified="2011-11-16" version="1">MIRIPALSRRGIIRSARQVSRVYALPAFRSFHFTNVLKLTEPIRAIDNSDNTPWYLREEQNISTKPADRPPIPYVPESAPSTVTEFLRLLAEEYGLQEIQLFDLNTLDASHPQSVENQPFDYIIICTGKSERHIYKAGQELKHYIKHNFQKQVKVNGLVSAAPNAVARRRMLKRANKAPLATDNDYGKTANSWVMCETSVDNICIHVLTKDRRAELDLESLWVEEKAPEPVEKQEESVAIKNVSDIPEFFLTRRKLHTSTRYINHELATCLTNLMEEEVDSLNSQKLNQYITEFEASFVNPNVEDHKFRSIFYSILHFIDHSVVSLEKVTEVMLDKYADLAIAIDESVNMKHERSSDVTTYMKVLIDSPQLQASLEPKPRSDKAFDMLAQFSMNVYRFSGETIDPEANPEFIPLLWKLAFTSTNNGELDLGPSVIDETLYDNKDYYHQKFSTSVQAENRTRDMMEVLNFYLGLKSDSRSFSRSFKELQLFSLGNSGRWDEFWNHWDVSMSLLDDKKDIQRWARLIVYLALRNDVRANKIFVQEYWSGTHKMSGSFMEQFQARSGDLKESETHHLKVSLGLILESQHKILPDSALDEIRTFASTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B929</accession>
    <name>G3B929_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Plasma membrane iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_107377</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B929"/>
    <dbReference type="STRING" id="590646.G3B929"/>
    <dbReference type="GeneID" id="18245949"/>
    <dbReference type="KEGG" id="cten:18245949"/>
    <dbReference type="eggNOG" id="ENOG502QQWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046738_1_1_1"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43145" checksum="A6B1B16C330187A7" modified="2011-11-16" version="1">MVNVFNVQIFFIVFREALEAIVVVSVLLAFLKQGLGGVHDDPVVYKKLRLQVWLGSIIGVVICLIIGAGFIGAFYSLHKDIWTSSEDLWEGVFCIIATVIISLMGIAMLRINKMKEKWRVKIAQALLAKPKKGSWFRLGYYSRKYVMFILPFVTCLREGLEAVVFVGGVSLNSPATAFPIPVIAGLIAGIAVGFALYYFGSTFSLQIFLIFSTCILYLISAGLFSRGIWYFETYVFNKKTGGDASENGAGPGTYDITKSVWHVNCCNPEKDHGWDVFNALLGWQNSATYGSVISYNIYWLSLIVVISLMLFQEKTGHLPFTKNLTLRQLNPMYHIKGKKKLELTKEEQDELFERVRNEKLTVGADSDSVQEKVEKTEATAVTTASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9D3</accession>
    <name>G3B9D3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Restriction of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_126525</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat RTC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9D3"/>
    <dbReference type="STRING" id="590646.G3B9D3"/>
    <dbReference type="eggNOG" id="KOG0269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008512_0_0_1"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16488">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6 12" id="KW-0853">WD repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="1071"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="569"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="734"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="790"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV62477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1119" mass="125228" checksum="4FAB96AE6916A73D" modified="2011-11-16" version="1">MSNNSGHSNLAKFAFNIYGTLNNSSSLDNSSNHSPPSSSSSTRSKIGYLRSSVADNLTYNCEREVNCLTELEFVNNSGFINNVVIGGKNYLKLLMLNADQTSILNEANVLEALSNPASRLPGSNKLHNFNTIKSYSNTIAGGMVNGSLTLFQVQNNGKSRAMKRLTDHTRCINSLDFLDPSNSDMSSNFLISGSQDGSIKLWDLRQSNNKPSVNIVPKSNYDSVRSCQFSNHSLVKNKLVILSVHDSGTLNKYDLRSIHQSTQSSVVPERKWNFHTGPALSLNIHPEKEYVITCGRDQKVCVWNYGENQNNYSNTSPEHVINTYGPVMKVRWCPYSNPSKNNDEDVLYDDRDLNTSNNPLFKYDFACSYLNEDPTITVFNLKRKYIPKEIVTSNSKRPYLNFIWANNLNGKRRLWTLTKGNQFMSRCLDSFSEYDNITRPKELLNPVSQAWGTSIGDISFINQEENEFENTEPLEKMSSEAFFDTIYDSEVDTNEANDPNDYNKVIIGSYQSSFNSPPNSSLATSPIEQAPHSRPALFRSATYNNAGFPAKATSSSPQLRNSLSSYNIYDSPLSRRPTMGRNPSQTTIDSNPSMGSPVNRSDFNPDTKRAISIHYASPYIVPVSLALPLNDDIVFETLSNNYILTIPDGFSLVDVCLLNASVAGSVNRFRDCQIWRMLAVGLGQHVDGVLNDDAVDVNHYSNGDTATEPDDNNDNKSILSDYGNFIGSYNSNSTSTTHYGGSESTSEKRSANPRSWSETKNSSSNNLLDMINQNRNNSIVNAISISPKGNERFKQYSPSPKNLSLLSRTKPKRGSSFTQASKEQDMDLDNENLNVMNNAISSSFSSSAMSAAHTPDNRSTYGSNNYVGSFKSRRSSSIAPTYGFSKNRTFDQGLPEVDEVISNHSSRMGDSFKESGLTRAIEGIKEKPKDSNYLEVPWTITKLLQKALEHATLQGDVIFCSTLCLLFFPFTKSLGLRFLKNNYCLEWLSLYIEILQKKRLYVNAMNILNDSPRELQEKLLTLYHTDTLKLYCQNCNSLIVNEEAKMKFNQGNTKVFGYWYCEQCKSKQSNCVYCNEPCQGLNVVVSLNCGHRGHFGCLREWFVDGQNLECPGGCNELLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9W8</accession>
    <name>G3B9W8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_94253</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687514.1">
        <property type="nucleotide sequence ID" value="XM_006687451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9W8"/>
    <dbReference type="STRING" id="590646.G3B9W8"/>
    <dbReference type="GeneID" id="18250377"/>
    <dbReference type="KEGG" id="cten:18250377"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445500_0_0_1"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="435"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="605" mass="68134" checksum="1BDDDD4D7AF391E3" modified="2011-11-16" version="1">MGNNTSQIRRSSVTYNESNVRRSTTSSQRPDHQNLDEEFSDLILHEVKKDQDIRQQNLFNQSVAVPESLNRHPSLKYNQFSNDLIEDEFNELKDLIETDEAELTRNIIPNDKDVHKDDDDDDMIGVDENDTTLVVNNHNEVDDNMDVDYANHASGSTTVETVTPDLSSVDFTKIVANASPGAAARSPVGGYRSKPTVQPMTINSSGSTTNSHGGIVDVNSNGIVPVEIKWVNVLKENIQKVSIIGSFSNWRNIIRLKPLPHLPNEYVVTIRLPLGVHKLLYIINNEYRVSDQLPTATDSEGIFFNWFEVLDGSHLFNHSQNQPDRIVSASTKYDANIIQSAGQHEIGEIQRKSHSFLTKISKEDHPNVEHLEYREDPYEADEMQQEMQKELLQQNPSAHVPASVHSSSPDKNHHPNEPYILMSDNNSSSFLLQQRTNNQIEYSGEIPEIFVNYSYFKSQNSNFELPEPPQLPAHLNNVLLNKLSNHNNSNTQLPAHNTSYPPHTHNYSSDNGTMPQLDTFKPPSASFMGESSSSKRPPLRRADSSYYASNQEAYHLSIPNHVILNHLMTTSIRNDVLTVACITRYSGKFVTQIMHSPADSLSGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9Z7</accession>
    <name>G3B9Z7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_98613</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687533.1">
        <property type="nucleotide sequence ID" value="XM_006687470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9Z7"/>
    <dbReference type="STRING" id="590646.G3B9Z7"/>
    <dbReference type="GeneID" id="18250786"/>
    <dbReference type="KEGG" id="cten:18250786"/>
    <dbReference type="eggNOG" id="ENOG502S71X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162182_0_0_1"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="94" mass="10781" checksum="CCFCF8E540CD11E2" modified="2011-11-16" version="1">MQPYSRSGGTRKCFYEFQTLAACYTSADTVSKKECLPQFDDYFECLHGYKEREKVRLMLQQLKDNEASQKGITASDLYKSAGAVYENLDLITKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAK2</accession>
    <name>G3BAK2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_135387</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAK2"/>
    <dbReference type="eggNOG" id="ENOG502SKTW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458534_0_0_1"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="595" mass="68803" checksum="2669C249BD6079BB" modified="2011-11-16" version="1">MSMCTNHIITRLIIYAPTTLSYFARAYGRQTISYMTSLKDSKGLGSIRNPDNNKRPCFECYKRRIKCDLIKPTCGKCHKKAIQCHFEKNRRFVQYAVSDRAQKRLPIHLQPSHQEMNKLKNNQSLVLCQEGFGFEENEALDMSVEAPGTKTGISEYYPLTRISLSDSFRLTIHDLSKSVNMLNGNNPTSYYFVDQALIFKLFDYFNEVILDQMVPFDNANSPYRKYLVPYSEISQDILITLICIAGEHLYARKLMSKAILDSLSTGLSEMLCLSFMSVSNTIQLNKNNYFENESFAIKCLNLLMQISYSIFRCDQTDTQMRFAEQRNYLRLVNESVVRHNLRFHVSSSTSTMFIIQRLVFNDVFMSSLNDTRPVVPKYILEYLLHCELNQADVSSLLSIIGCPVQILLIIYEIEVLSHDIAKESSTKSDDDMISISKEKTESELRFVKKLEDYKRLNEETINLKDDSSNFSVLVEIYYHSAYILLLRKICHEDPKSARMVFHVDRVISIVTEKILVGSGPDSCIAFPLYIAGREAVLEAHRAQVLNFINLSEWHLNLGSQRLARSLLCDHFWVKDQENMEEVQKKISKEFPFIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAQ9</accession>
    <name>G3BAQ9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_108759</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAQ9"/>
    <dbReference type="STRING" id="590646.G3BAQ9"/>
    <dbReference type="GeneID" id="18246059"/>
    <dbReference type="KEGG" id="cten:18246059"/>
    <dbReference type="eggNOG" id="KOG0277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046581_1_0_1"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="369" mass="40966" checksum="F22D354771D90533" modified="2011-11-16" version="1">MLSFRTSGYNGYGVQYSPFFDNKLAVATSSNYGLVGNGRLFVLSIAPSGQIINDISWDTQDGLFDVSWSEAHENQVVGACGDGSIKLFDLTVGQFPVMNFKEHTREVFCVNWNMVEKNTFLSSSWDGTIKIWDPSRAQSLFTLASERDSSIGGGGQLASSVPISHQQNHRQINTANCVYNAVFSPHSPSTILSCNGGSRVQVWDIRSPRPLTVEYIAHSGLEALSCDWNKYKANIVASGGTDKSVRIWDLRMINRVDQSVPGMPSHTARGPTPLNELLGHDFAVRKVVWSPHSGEELLSTSYDMTCRVWQDKSNERARFLNTGVGGCRGIMKNHREFVIGADYSLWGEPGWCASTGWDEMVYVWDSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAR4</accession>
    <name>G3BAR4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_94975</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Also acts on 2-methylisocitrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688260.1">
        <property type="nucleotide sequence ID" value="XM_006688197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAR4"/>
    <dbReference type="STRING" id="590646.G3BAR4"/>
    <dbReference type="GeneID" id="18250462"/>
    <dbReference type="KEGG" id="cten:18250462"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="519" mass="58282" checksum="B0DD16431FA8DF9D" modified="2011-11-16" version="1">MGELEDTYQKDIKEIKEWWAMDHKKHLTRPYTAEEVAQFRNSVKTDYLSSIQARKLWKTLNSYRAAKEPLMTVGCVEPLLASQMSRAGLECVYVSGGVSGLTQVEEPGVDHADYPWDTVPRVVNRIVKSQMWRDRTQRQHLLSLSEEERKTYPQFDFLLPIIADGDMGFGGVTTIAKCTKVFVEAGVAMFHLDDLAIGLKKFTQGIGRTIIPTSEYLKRLTAARFQIDVMGADTLLMSRIDSYQCGFITSVFDARDHKYVMGSTNPDIAPLIKVLADARQAGESIGAAKLKWFKDAAVMTFDEAAEKDLSADEFAAYSKLIDGDKFASLTKRRKYAKEAAPEKTIFFDWDDGRNSYGHYLFKQCIESVIDRAIAALPLTDTTWGRVDAPIPADVEKFHVELSKVSPGRVFGFGYVGAYNFAKAGYTEEQVKNFHNDLAEMGAIWQVQPIFAIQGINMFNNEFLNMWKKEGIFGYARDITKKAEDPAPFKPGAFASWGGGYLADGFIDITDANDHQIPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBE4</accession>
    <name>G3BBE4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_109741</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBE4"/>
    <dbReference type="STRING" id="590646.G3BBE4"/>
    <dbReference type="eggNOG" id="KOG1746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111220_1_0_1"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="124" mass="13990" checksum="B14DA094672881C2" modified="2011-11-16" version="1">MAKPKTSKPSTKTLGELRSAATTTYTNYVKSLTPRTKLIDTFLAFLVTLGALQFVYVLLIGNFPFNAFLGGFISCVGQFVLTVNLRLQYNEQNFSLFKSTPERSFGDFIFASLILHFIVYHFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBK0</accession>
    <name>G3BBK0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115023</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687727.1">
        <property type="nucleotide sequence ID" value="XM_006687664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBK0"/>
    <dbReference type="STRING" id="590646.G3BBK0"/>
    <dbReference type="GeneID" id="18247678"/>
    <dbReference type="KEGG" id="cten:18247678"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041844_3_2_1"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="106"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="424" mass="48608" checksum="BC9B9BA2B2C35300" modified="2011-11-16" version="1">MSGKWYLPTPIVVVRNIILLIFFLFGCVSIVWTQRVFLFILKDRPKYRHSMINLTKRHFLQLFTFVISILNSTTISITYDPSKLPLENSFSQLPGNLISTSLSPNSVMISNHQIYTDWFYLWFLNYTSRLSEFVYIIMKDMSKTPILGYGMTNFNFMFLSRKWDEDKIKLTSQLLEVDANARGSGPASGVRHVTSFRATTSVSDVQSWPKEKVSDDISPYQILLFPEGTVPSLRTTKKSREFCDANNLPPLKHVLLPRIRGLFLVLRKLRGTVEVVYDITTAYGGLKAGEFGEDIFTLKGLFLLSRGPEKINYHFRSFRIEDIPLGDDDVADVDLVDEETLKKFENWLFQIWYEKDALMDSFYKHGSFVSPNSSSNNTVEKVSQHTVEGGVKLRSVLEIIPVFGTAGATVLLLVGLYRLLRFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBL8</accession>
    <name>G3BBL8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_115035</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687738.1">
        <property type="nucleotide sequence ID" value="XM_006687675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBL8"/>
    <dbReference type="STRING" id="590646.G3BBL8"/>
    <dbReference type="GeneID" id="18247684"/>
    <dbReference type="KEGG" id="cten:18247684"/>
    <dbReference type="eggNOG" id="KOG4780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086709_0_0_1"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="50"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV61569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="272" mass="31220" checksum="A9BD5D5933D56B06" modified="2011-11-16" version="1">MALLTLPQFIPRLEPFGGRELLTPADTSKLSLVITELLIDHPVDIDLLKFLSRFLTQQSYDEIVEERNIEHQCGYITCQNTPRHQVRRLSSNSNGTTTCNNGETKFQIYNRKPSIILPNTYLSQYCCKEHYQASLFYRNQLSSEAVFARKNIVVAPPFPLHYPGSWYENGITCLEEVLAKHHELKNQGKSLSEVVRMMNGLTMEDDEPGHDTSELIKLIEDFEIVERDTPLPEGAEDDSAVLDDDEDEEFPYNPRKIDGYITTNKHYNGYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBQ6</accession>
    <name>G3BBQ6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136148</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688380.1">
        <property type="nucleotide sequence ID" value="XM_006688317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBQ6"/>
    <dbReference type="GeneID" id="18249942"/>
    <dbReference type="KEGG" id="cten:18249942"/>
    <dbReference type="HOGENOM" id="CLU_1098368_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="253" mass="27531" checksum="7A8D14AE6F53294E" modified="2011-11-16" version="1">MAKTTYSIDTLLSLKTSQKIDLGSKLDELFPPDLQQPGRTLPQKPNFNPRRNRFKTPQTPTQTSSLDLISQLSGYENAPVRFPIPGVYSYPITVCPENMPFAPNCYPGFLQLPAGSRIVAVEHGKKVPQGAIPVPPALLNSNFYGPYPLGIPNMNYAPQEGSKALRWQPLGFQQASPAPKNTKLSRSFGAGHPASMPIRVAVPAPTPACEPETQPAADSLSTKSYVSNDDETVSTLGSSYDSYNIQIQLPKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBW9</accession>
    <name>G3BBW9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_110982</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBW9"/>
    <dbReference type="STRING" id="590646.G3BBW9"/>
    <dbReference type="GeneID" id="18246238"/>
    <dbReference type="KEGG" id="cten:18246238"/>
    <dbReference type="eggNOG" id="KOG1713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_0_0_1"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="12">
        <location>
            <begin position="91"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="277" mass="32185" checksum="6BD4C9707760E151" modified="2011-11-16" version="1">MLRSSVRINSIGLLGKRLLQQSSVRYNSSYELPDLSKLPRRKPTEVHVPLVNPADQYKETSEELHKFGRYIMSCMPKYIQQFSVWKDELTVYVAPSALRPTMIFLKNHTSAQFKSVMDVTAADYPSRSNRFDVVYNMLSVRYNSRIRVKTYANEISPVPSIVPLFQGANWYERETYDLFGIFFEGHPDLRRIMTDYGFEGHPLRKDFPTTGYTEVRYDEEKKRVVYEPLELTQASRSFTVPHSAWEQVGDGKDFTPESFKLPTPEPEPEAEEKGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBX9</accession>
    <name>G3BBX9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIRA-interacting protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116123</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBX9"/>
    <dbReference type="STRING" id="590646.G3BBX9"/>
    <dbReference type="GeneID" id="18248178"/>
    <dbReference type="KEGG" id="cten:18248178"/>
    <dbReference type="eggNOG" id="KOG2358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_0_2_1"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="214" mass="24034" checksum="22E6BC12075349DB" modified="2011-11-16" version="1">METPNEHALKFLPSMKILNENETKEFLSGREASVSPLAVKLFSVDGVKSIMFGSDFITIEKHNNDLHWALLKPEIFSILTEYLTNGTPILNEGTTLSPDMEINEEDDEVVSMIKELIFTRIRPAIQDDGGDIEFVSFDEEDGKVMLKLKGACRSCDSSSVTLKNGIESMLQYYIEEVQSVEQFDEEEVDVSMEAPVVEAPLTLKPRARDEPPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBY5</accession>
    <name>G3BBY5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_131977</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 large subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="EGV60115.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RFC_lid"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="73"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="735"/>
            <end position="774"/>
        </location>
    </feature>
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        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="748"/>
            <end position="765"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV60115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="774" mass="86434" checksum="156A4949605E7107" modified="2011-11-16" version="1">MVLVTDFFKAKKPAAKREQPSPPSGASAEEILASIPDAELPDTSDSQKLSFFQLQQRKAQAPQATGSVDIPEAKPHCLSGLTMVFTGVLPNLERTDAENIAKRYGAKVPKSISGKTSVVVIGDEAGPSKVQKIKKMHIKAISEEGFLQLLRSMPADGGSGGEAVKAKRKREEEESRIIQEAEAEEEQERARQQQAKIQHVPPSVSKHSSRLPAEPVREISNDDKLWTTKYAPTSTLQLCGNKGQVNKLRSWLLHWFDNAKNDFKDPGADGSGVFRACLISGPPGIGKTTAAHLIAEDLGFDVLEKNASDVRSKSLLNSDIKSVLNNTSVMGFFQNRHADVHQENERRFCLIMDEVDGMSSGDHGGAGALSQFCRITKMPMILICNDKSLPKMRTFDRVTYDLAFRRPSENEVKARIMTICHREKIKIDPSIIGQLVQTTNNDIRQMINLLSTVSKTQKTIGAEQSKDFSKSWQKQTVLKPFDIVGKLLNGQIYSPHSNHTLNDKIDLYFNDIDFTPLMVQENYLYTRPSNCRDDSDHLRRVAQAADDISASDRINSLIRSSEQQWSLLPFHAVMSSVKPSREVAGNISQRINFAGWLGQNSKQMKYQRLLQELQYHTRLRTSTDKKELRLEYVPLLAKRLAGPIVSQGENGIQPCIDVMDYYFLTREDWDTILDFGVGAAKGEAVLKKIPTKVKTAFTRTYNSSTHPIAIYKTGNSVGTTKSTASTVDYEDVIQDDTLKDDDDTEEKDDSKFDSKKDKLIKEVKPKKGAKRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCC1</accession>
    <name>G3BCC1_CANTC</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116868</name>
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    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="125" mass="14184" checksum="5F06F1718DA2C3BA" modified="2011-11-16" version="1">MTDFAFDNYCINCEKMCSTNSIYCSEACKRVDESNTQRINSTFVPIDHIASPLLSPNYNYNYSYQGQDSDYTYSYTASDGSASDNYYIPLDSIDEINLNYSLSESANNIVSTSHNYKKWLTGTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD06</accession>
    <name>G3BD06_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_110965</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006690040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD06"/>
    <dbReference type="STRING" id="590646.G3BD06"/>
    <dbReference type="GeneID" id="18246237"/>
    <dbReference type="KEGG" id="cten:18246237"/>
    <dbReference type="eggNOG" id="KOG3146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074922_1_2_1"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF59">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="55"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="233" mass="26793" checksum="AB2882924D55FA2E" modified="2011-11-16" version="1">MPTYEKYNPVPFDLTYVVYDPNDPLGLLMVHFSLFPIYTMVFYASWFLLSREVEPVIVVAGHLASEIVNKITKKILREPRPDFHKDFGTGSLTYGMPSAHGQHMGFFAGYFICILLFKINHITNHQKMMGCAALAFSSMGVCFSRVYLKYHTPQQVLVGTLFGAFLGCLYFVVSSILRDVGVVDWVLSWRIVKFFYIKDSYFHAYQSFKDEYEFYLSLKNTNILASNLTDAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD15</accession>
    <name>G3BD15_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_110464</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD15"/>
    <dbReference type="STRING" id="590646.G3BD15"/>
    <dbReference type="GeneID" id="18246196"/>
    <dbReference type="KEGG" id="cten:18246196"/>
    <dbReference type="eggNOG" id="ENOG502S429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151420_0_0_1"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="108" mass="12006" checksum="1C7F6A53F8058992" modified="2011-11-16" version="1">MVDLTPIAKYRAPDFTNEHEIGVGDGPHTTDGKTTQISDVVIKAGGQDRDRPTEASNSSLGQLRAKLTSLQDNINIFLTERMKYAKEQDSKDIERRILDDGVDEDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD26</accession>
    <name>G3BD26_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_110026</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690116.1">
        <property type="nucleotide sequence ID" value="XM_006690053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD26"/>
    <dbReference type="STRING" id="590646.G3BD26"/>
    <dbReference type="GeneID" id="18246165"/>
    <dbReference type="KEGG" id="cten:18246165"/>
    <dbReference type="eggNOG" id="KOG0036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_2_2_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15898">
        <property type="entry name" value="EFh_PI-PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="204"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="337"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="442"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV60902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="537" mass="60740" checksum="F5CBCBA7B49D0425" modified="2011-11-16" version="1">MTTKLSVISKDEADLTPEEREQKNILVSIANTKPNDYEKLFSKLDISNNGEITLQEFKKALLRMDHPVKENEELVKRIFTSLDTNNDNKVDFNDFKLYLTVTDDQILQGFKKIDQDNDGKLNKQDFAHYLNKKLHLSPTTESVDTIFNQIDTKHDGFVTFDEFRDFLLLMPRLDGSRIKTAFQYIVEELDISSDGDVTVINQFLNGFGYFLAGGISGVVSRTCTAPFDRIKVFLIARTDLASTVLTPRKVIEERISHRTVIEEAKKAEAHLHHKTIRSPIIQAARTIWKQGGFKGFYVGNGLNIFKVFPESAMKFGTFEFTKRLLATVEGVEDTKDLSKVSTYLAGGLGGVVAQFTVYPIDTLKFRLQCSNIDANVSLFNTAKDLFREGGLRIFYRGIFVGVAGIFPYAALDLGTFTTIKKWLVKRQMTKYGIKHEEDVKLPNYMVLGLGALSGSFGATMVYPVNLLRTRLQAQGTYAHPYRYDGFRDVLQKTIQNEGYPGLFKGLVPNLAKVAPAVAISYFMYENLKNIFELETNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDF2</accession>
    <name>G3BDF2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_117010</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690157.1">
        <property type="nucleotide sequence ID" value="XM_006690094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDF2"/>
    <dbReference type="STRING" id="590646.G3BDF2"/>
    <dbReference type="GeneID" id="18248540"/>
    <dbReference type="KEGG" id="cten:18248540"/>
    <dbReference type="eggNOG" id="ENOG502RXIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084253_1_1_1"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="162" mass="17906" checksum="793AD51EEEBA25C7" modified="2011-11-16" version="1">MTVAKEFEKSNQKYVDQFAKGDLALPPSRKVAVVICMDARIDPAKALGLEEGDAHVIRNAGGRATDALRSVIISQRLLGTREIVVIHHTDCGMLTFTDESLRKQLVSEADENVDHFAFLPFNDLEKSVVDDVKFFKKNSLVLDVPVSGYVYDVKTGAINKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDY1</accession>
    <name>G3BDY1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_110283</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDY1"/>
    <dbReference type="STRING" id="590646.G3BDY1"/>
    <dbReference type="GeneID" id="18246182"/>
    <dbReference type="KEGG" id="cten:18246182"/>
    <dbReference type="eggNOG" id="ENOG502QT4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014765_0_0_1"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="57"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="261"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="697" mass="79348" checksum="8ECE14D6AD537DAB" modified="2011-11-16" version="1">MSKFLNPYGPRPWFHVSRIRYISSTSSTPIKLRDYQIKAIDAVKSAIQRGVRRPAFVMATGGGKTMVFSHLIPQLPQMDPQRGNKVLVLAHTEELIKQAAETIARINPSLKIEVDMRHMKPTFEGDIIVGSVPTLVRTVRLNKYNPKDFKAIVLDECHHASASSWSKILKYFNADTPQSEVIVIGCTATLERSDGKSLGEVFDEIVFERSLLTMVKNKELVDVKFSSLKVDIDLSSVPTKNSDYETVSLSNLINSTETNLLVALSYRKLREEYGFRSTLMFCVDINHCKTLCGVLQRSGINAQYVTGDTVKHERRTIIEDFKNGKIDVLCNVLVFTEGTDIPNIDSLFLVRPTKSRPLLVQMIGRGLRLHGNKTHCHVVDIAGTRGTGIQSVPTLFSLPSDFKIHGKSYQELQKEGEEYTLAQKELEKQEQLENEKLRLLDEQATYSKMVQLNNLENKLDLEFLTVDGFLALESKDMQDFKEFKQIHSTLASHSLDWIRLEYNIWGHQIDEHFFLLERINLEHENTLFKLWATGFTSLQHRVASNYKCGKFTTKTEVISSYNLDTVLAKASVLRNEIQTTFGRLRDSSPLTAKQSNYLESKLGIKLKQYYDNSPELQGKLKEEISKLTRRKAANLIFAQKYSSKALFVGWELQKMLGSNKRTRKTIKKIVKSETLASKHLPNISNITPLHIFQHTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDZ1</accession>
    <name>G3BDZ1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_99846</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDZ1"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF10">
        <property type="entry name" value="S-ADENOSYLMETHIONINE PERMEASE SAM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="62"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="564" mass="62373" checksum="1586AA8A4FEAA930" modified="2011-11-16" version="1">MGCVPDNSRSSAIKPLFSRIIDSFKPIDLEDDGIDTSEMSDLEKAIYGTSRHPLARRLKNRHIQMIAIGGTIGTGLFVGNGYALSFGPGSLLIGYTLVGIAMLLVMNALGELASQFPVSGAFNAYFTRFIDDSFGFTLGLLYACSWLISFPSELIACAMTIQYWNDTINPAVWIAVFYVIISGINLFGVKGYGEAEFVLSLIKVIAVIGFIILGICIICGVGSQGYIGGKYWHNPGSFNHGFKGLCNTFIVASFSYGGVEMSALLAAESENVRKSIPKAIKQVFWRITIFYFLTSIVIGCLVPYSEPRLLNGQSDEDIRASPFVIAINNGGIKVVPHIMNAVILLAVVSVGSSSVYGCSRTIASLAAQSLIPKIFGYIDREGRPLVAIMVTNVFGLLGFLVASENEGVVFTWLFSICSLSSFFTWFNVCLTHVRFRWALYHQGRYTDELVFESRTGLWGSYIGMVLIGLIIVAEFYVAIFPVGGDPNAEQFFQYCLSVPLMLVLWASHKTVRKSWGRLYVKLEDIDLDTGRREVDIEYLKQDLANERAELAAQPWYIKVYKFWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEF8</accession>
    <name>G3BEF8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_95984</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689749.1">
        <property type="nucleotide sequence ID" value="XM_006689686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEF8"/>
    <dbReference type="GeneID" id="18250564"/>
    <dbReference type="KEGG" id="cten:18250564"/>
    <dbReference type="eggNOG" id="ENOG502RQ81">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112097_0_0_1"/>
    <dbReference type="OrthoDB" id="4022090at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="218" mass="24642" checksum="3381AF828244662B" modified="2011-11-16" version="1">MSTTIVEMLVRVASILMTTTIFVISNTITIVQYSNAEYPQITQPILALVGLYVSYRFTKRIITSWLNMVVFMVKMFLLLITIIVGLAAYLRGERFFSQDIPFLQQAIQEYNGEAIQEFVGAKMNQAMFSNLFSSFGDSEPEKKTKTKTKKPKVDKGKKFQKKAKRVMKEHGIEIDSSYLDYLNENLGYGGDENILDNVGAALDGLGLDVSGFMDRFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEH3</accession>
    <name>G3BEH3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial glyco protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_95993</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEH3"/>
    <dbReference type="STRING" id="590646.G3BEH3"/>
    <dbReference type="GeneID" id="18250566"/>
    <dbReference type="KEGG" id="cten:18250566"/>
    <dbReference type="eggNOG" id="KOG1762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792251_0_0_1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF33">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="350" mass="38334" checksum="5A0D0CFFDC162E0F" modified="2011-11-16" version="1">MLSRLSRTSRLPVRSVLGSRTLAPTFRSSPILAMRYYSSPDKELKQILKEEIDIVKQIPNELDNSFKDFLIDNKVEVTAVDGSSNVELTKHLANGEILKVFFDIDEVTDIPVDELANEEGEVKEVDFDESISNVDSLLCSIKVLVAKPTGEGLFLNLFLQSSESAFLVDFITHKPDASKFLEEARKGDFLDKVQYQGPRFSELDESIQIGFENYLESIGVNHELADFILSFSELKEENEYRQWLARCLDASISYAALILADAGLEITSDNLVSIAKAAKADVDSVWADVFAKALEGKDLKDLLFSLAAAAPASGSAPAAAAGGAAEEAVAEVEEEAPEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEJ1</accession>
    <name>G3BEJ1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116636</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEJ1"/>
    <dbReference type="STRING" id="590646.G3BEJ1"/>
    <dbReference type="GeneID" id="18248380"/>
    <dbReference type="KEGG" id="cten:18248380"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618202_0_0_1"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="443" mass="50638" checksum="D7180A111EA2CDA8" modified="2011-11-16" version="1">MADNRHLMMANPMLMSPPLNPQSAHMPQQMGTSRLAPPRMQRSLVNDPEIQHKIQSFTNLRAVIASGNKSYEYRLKWVKMLINATNYRLYVYINIKGEPIASSDATANKELFIKSASQHIVKLIRDVDSANQKLTDDIRSDICLVYANILSHHYHTLYEQSFGMQKDIDGAIAWYERAIIFNPSNFKAHYVLGDLYEYEVNNGFDQALIYYRQSAKLGYNRAIYKMALMYLNIPSIRSHKFIKILRDLCNIEVEKTELDDDDKQELTEIIASASYELGKVYEGVYPGDLTVEDDFIQKCLEIVPVNYGKALSYYNKSAKLNYPVGLVKLGRVYEFGELNRTKNPHKSIQWYLKAVSSPLPFRRNPDAMIGLSRWYLSGSNGESKHIPQPNPERALKWCERAIKESNSPDAYYQMAQLADAGLSNQPATYWCQKAAAVSDPVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3BER3</accession>
    <name>G3BER3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5 6">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_127940</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5 6"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BER3"/>
    <dbReference type="STRING" id="590646.G3BER3"/>
    <dbReference type="GeneID" id="18249268"/>
    <dbReference type="KEGG" id="cten:18249268"/>
    <dbReference type="eggNOG" id="KOG1384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_2_3_1"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="465" mass="53221" checksum="513357F423276A06" modified="2011-11-16" version="1">MFRYLRFLKNSIMTTPKKSVVAIVGTTGVGKSKFSIDLAHAINGEIINADSMQVYKKLDIITNKHSMAEREGVAHHVMDHVNWSEDYFIHRYAQEANEAIERIHAMGKIPIIIGGTHYYLSKLLFKNKTVEDGHAQPLTAAQLAVLDGPVERIFAELEQHDPVIAQKFHPQDRRKLRRALEIWYTLNEKASDIYREQKLEELEDSSLMYSTLFFWVYSDPDVLRDRLDVRVDSMLAAGAVDEIRELFKFYRAQSPPPTLTSGIWQVIGFKEFLGWLEAPDGDTTAKIKLWEEAVERMKIRTRQYAKSQVKWIKKLLSVELMKEQRFGFRNGGKLYLLDATDLSQWGERVQSRGVGIARKFVGGGPGAVDVDQKPDTIQEGIFPEEKDTAIVNSNKRLESSNNWQHFSCNICKDKSGNPVVAVGKDKWELHVSSKRHRRNATRPHKRPRVGSEPVYEGEPKDSNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF64</accession>
    <name>G3BF64_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116710</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF64"/>
    <dbReference type="eggNOG" id="ENOG502RXX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084558_0_0_1"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF1">
        <property type="entry name" value="YALI0C06193P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="245" mass="27220" checksum="7F58C971EC2A7BA4" modified="2011-11-16" version="1">MSQLQSQMEGLPGYDILMGFWEDYAGEHLNTIDPYEDENGNKRRLPSSSSQQEQRMWKIVQKKAWAHDKCFLGSCGVGMDCGVGLAPLVVLFFPVLGPLIMYGVHARLIHVVTNEMKLPGSLVAKMEANIVVDLLITFPPVIGCFFGYLHSCSTRNAGLIYKYFLFLAEQREKNNVPLYVGRGAIGHGPETVQPAYAGTARQNNYQNPNSVSKKPMFGQRTYSSGQRGKPSAQISVDQHQQSGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFN5</accession>
    <name>G3BFN5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116088</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689274.1">
        <property type="nucleotide sequence ID" value="XM_006689211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFN5"/>
    <dbReference type="GeneID" id="18248161"/>
    <dbReference type="KEGG" id="cten:18248161"/>
    <dbReference type="HOGENOM" id="CLU_1250508_0_0_1"/>
    <dbReference type="OrthoDB" id="4021666at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="221" mass="24869" checksum="6E26CB7CA2C04FC5" modified="2011-11-16" version="1">MESFSEEALQPVESYNEFLEWMEQRDYGGNRVVVCTSGLTSAPQPHTAYLPTPYSRSYPPSGTRFMTGNPGSSNRIGSPSNNGPPISGGAKFYSLQIDLHSAPANEAHQIDWKKQIEQIDLEHIDLDDLDGLMVDDDDEDEDEVAWRLDTEEFPHIGLFPTLTPREEMEDEQEQEQAFLDSHQQTQSNPVAPGLFPQMDLSDESQFSSLDMLPLNPSYIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFV7</accession>
    <name>G3BFV7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_116810</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFV7"/>
    <dbReference type="STRING" id="590646.G3BFV7"/>
    <dbReference type="GeneID" id="18248455"/>
    <dbReference type="KEGG" id="cten:18248455"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000009">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="152"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV60741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="336" mass="35632" checksum="20620D2497EF1B7F" modified="2011-11-16" version="1">MVKVTVCGAAGGIGQPLSLLLKLNANISELSLFDVVNVPGVGADLGHICSDSKTESFLPSSKEDKSALASSLKGSDLVIIPAGVPRKPGMTRDDLFNINASIVRDLAQGIAENCPDAFVLIISNPVNSTVPIVAETLKKNKVFNPKKLFGVTTLDIVRSNTFISQVFSGESKPTDFDTIVVGGHSGETIVPLYSLGKSADLYSKLSEDDKAKLIHRVQFGGDEVVQAKNGAGSATLSMAYAGYKLAESILKAFNEPNVVECTFLNLDDSIKGAAEAKKLVGGLDFFSLPVVLSKDGIAEVKYDVLTKANADEQKLLEVAKEQLAKNIEKGVKFITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW59</accession>
    <name>G3AW59_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein DML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein dml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_101174</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW59"/>
    <dbReference type="STRING" id="590646.G3AW59"/>
    <dbReference type="eggNOG" id="KOG2530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022511_2_1_1"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="9">
        <location>
            <begin position="118"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="478" mass="54953" checksum="121B7D8827ECCF12" modified="2011-11-16" version="1">MGEVINIGCSQAANHVLTHLYNFQEAHIPYKRDQVLRYDNKVFLSSLKLNGKTNYSPRALIYDARNGFGSLGKYDYYDLEDHTYSPSGQGIEIISTNPKVPKNEYQVGLDKGLNRSNTLTVSNTSYWSDYVKLIFRPMSLKSLESYELNDSNKVVHRLSPSMQFTAFNLGQTEFTGKEDDAIDTFRKMLEESDFFEGMQLFTESDSAWSGFTTELLVSVKDEFFNYTSNNKFNIWIWDLMKNTRLTPFENLTRIRSLVEFSTNSSLVIPLNSPVEGTNWQTGGLQSVVVNSLWELINSSPRISTMKEIESNLLGNDSNRNIVNHVSIDELKEPALDKLSLYDVGSPEKSLEFGFNNKSVHRFSTHYTVNTWDKDMFLTSKPKPDAHVYYTNNDILDITKVDTFPPVLEFSKAYTEFGIDSSIRYDLKKLIDYIRRTSTSMGLILGEKDEVLQQLHDMRRSYSDSPDFEDDSDEDYDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXL7</accession>
    <name>G3AXL7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase MRP protein 1 RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_133045</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXL7"/>
    <dbReference type="STRING" id="590646.G3AXL7"/>
    <dbReference type="eggNOG" id="ENOG502S2QW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031977_1_1_1"/>
    <dbReference type="OrthoDB" id="5414547at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22573">
        <property type="entry name" value="RMP1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="177" mass="20737" checksum="99C0F9093FACEE46" modified="2011-11-16" version="1">MELAQEAYDTLINETQVLQLIYHRNKNQHRLSGWWKYFKMLLTRLKRIVKDPIKKNVTVLYQKKIINKCFYEFYGIIKLGQFMSLGLVLVASLSKINEILKAYTELRVPTQIDQQNIYLQDSDDIGEVITEHIGETITKSEGLSIGKTELMKTKDKHLKKDKKKKKKTKSDIDKIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXQ7</accession>
    <name>G3AXQ7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_129148</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXQ7"/>
    <dbReference type="STRING" id="590646.G3AXQ7"/>
    <dbReference type="eggNOG" id="KOG0596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019372_0_0_1"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="380"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="706" mass="79800" checksum="0106CE88BCE5042C" modified="2011-11-16" version="1">MFPRDIVPERPAKKHLLEDDHTFLPPALSSYSIALLNDRTSQSKPPPQNPHITGIYDLDFPQSGRNKLKEKLSMHFRESAYQSSTSENPFLRSSKSSNEFQPDPTNDVVNPNANTSITSSYNQHSNHSMSHPGSDRNLSHNSVTKLSNYNANLSNHHMSLSNHNTNNLSEQASDPLPTTNPSTYRTASPQVRYRPSSENSLSDRFTDRIMPPVKRLRGPKRFGKLIGPPQRVVRTSVDTPSPVQEQSKRPSPSSNEFDLSFLDKDKELELRKRIEEQKKLNELESRRARADAKAKAIKALSTHEEPVSMERIRNPLVELPPSQNNIARSDDNGFRKPKLPRPSPVKEKGAHDEEKENMTPVEHKPHPPRKKAITINNVQYEKLELLGRGGTSKVYKVKSLVDNRLYAIKKVTFDQFDDACIKCFKGEIDLLLKLRNNARVVQLVDYAIGEGQIYLVMECGEIDLSHVLHNRLKGDSKLDLNFVKFYATELLTCVQTVHQAEIVHSDLKPANFLFVRGVLKIIDFGIADSVPDHTANVYRDAQIGTPNYMAPEAWVNSSTEHKNTWKVSKPSDIWSCGCIIYQMIYGKPPYGKYSGNQRIMAVLNPQVKIQYPSKGIGGVPVPTSAIELMENCLARIPNDRWTVDRCLTSDFLKPKVVSENFIRDLVHSAVNFGYNNRANGTGIISTDVYDKLVETVMRQIEELNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXW0</accession>
    <name>G3AXW0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpE protein homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112570</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXW0"/>
    <dbReference type="STRING" id="590646.G3AXW0"/>
    <dbReference type="GeneID" id="18246587"/>
    <dbReference type="KEGG" id="cten:18246587"/>
    <dbReference type="eggNOG" id="KOG3003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_0_0_1"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000011">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="240" mass="26773" checksum="BBD4144CD5A851E9" modified="2011-11-16" version="1">MQRIQKLVPLASRATATRAAVLTTSSTVSTALSYRPYYSPVFAARFNSTKAKNEPQEEKQPEAAAEVEAEVKAEVHEDPIVAELQSKLTTKDKQLADMKNHYARAVADFRNLQESTKKEVQKAKDFALQKFAKDLIVSLDNFSLALNAVKEDTLKTNDEVKNLYDGVQMTRTVFEKTLTNHGIEKIDPMGEPFDPNTHEAAFEIPQPDKEPGTVFHVQQPGYTLNSRVLRPAKVGIVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY60</accession>
    <name>G3AY60_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_112641</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY60"/>
    <dbReference type="STRING" id="590646.G3AY60"/>
    <dbReference type="GeneID" id="18246616"/>
    <dbReference type="KEGG" id="cten:18246616"/>
    <dbReference type="eggNOG" id="KOG1694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066767_2_1_1"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19820" checksum="6738414B83F8A48F" modified="2011-11-16" version="1">MSQSAPKWYQSEDVPVPKQSRKTARPQKLRASLVPGTVLILLAGRFRGKRVVYLKNLEDNTLLVSGPFKINGVPLRRVNARYVIATSTRVSVDGVDVSKFNVEYFAREKTPRAKKSEAEFFDESAPKKEIKAERVADQKAVDSSLLSEIKKTPLLKQYLSASFSLKNGDRPHLLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYD4</accession>
    <name>G3AYD4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_129281</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYD4"/>
    <dbReference type="STRING" id="590646.G3AYD4"/>
    <dbReference type="GeneID" id="18249374"/>
    <dbReference type="KEGG" id="cten:18249374"/>
    <dbReference type="eggNOG" id="ENOG502QSII">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014358_0_0_1"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="787"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="922" mass="102179" checksum="C8D410BEB7C1AF50" modified="2011-11-16" version="1">MGKSHNINEVFTGGATTSQHIDAEDDDHFNNTTFKLKRTRSLGLLDEFISPLEEANKQENKDSTREEQESEAIEDPPTNTSKPTDNKLSINTSLEDQHTENDKPDSDKAVKTPFSPEFIPHDDNDIIIEPSIHVDYFSHQWDVSDISKSWRYIIQKRKDVANSARLENASWRTWAQRRSNLKTINPKELNWSKENDITWLYGPIVQEADASDDEHDEHEEHHKSTTATSKVAGDISIPNKPTKKSILKKRSVQDMMISHANLVKLEAMENRMKLKKAQRKEQLRKYNEENKGHKRTSSNEPPEFDDYEAISEKLNSQYRVSSNQSSSLNLIGMVDSKSNPNIVNENNLKDLDKQISNIDLGDTISVEPKEPVSKQSSNASNTDSISDKKSRRIHFNDVVEQCIAVDVIEDDSHDYDSNFSDEEEDNDEEYEYYNNESNKSQQSFIFTGHNDFEDTNDPDILGNDSDSDSNDEDGGFFLKVKSPSSSSLAPPSVSRDKQLEQVKTQDPYPGSQSSLDADATSISTTSSRIYRTIQLLPSTTLNYGSDEASSDEENPYTSSLSHNVNSSSSRGYDYYYDYNTVYTVDPNQGGYGDSANNNTPDVVDLPEDLAPYSSYDSVTEGGHESLPIIDSQVINNNVIYNNSPNTGPHSSLTSPTNLPGPGLPRSNPGGFSLNDSDSDSDSDSEDEGLSISTRSSSQSLAQQAYQSMTPANTLPVDYENKSSSGVGLNPTPVSNTVSSINPRHSSSTGLSKQSISSNSLTSQFFGTTPIRGPSSTSLADQFFNMEPSSSNEKSSPRSYPQQTQRKASPLPPHTTSANAFSGNTTPPLEKQIKRNKSSTFTFDSDSESEEEFVEDVQENVVQDSPTFSSPNSFESSYNSLSQVAGKNGIGGSEEAAPRDKNIVNQARGLANHFLGNWKHNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYD9</accession>
    <name>G3AYD9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="4">M1Pi</shortName>
            <shortName evidence="4">MTR-1-P isomerase</shortName>
            <ecNumber evidence="4">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRI1</name>
        <name evidence="6" type="ORF">CANTEDRAFT_112690</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="4"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684403.1">
        <property type="nucleotide sequence ID" value="XM_006684340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYD9"/>
    <dbReference type="STRING" id="590646.G3AYD9"/>
    <dbReference type="GeneID" id="18246638"/>
    <dbReference type="KEGG" id="cten:18246638"/>
    <dbReference type="eggNOG" id="KOG1468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_3_1"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000006">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="403" mass="44467" checksum="16ACDF37788BB424" modified="2011-11-16" version="1">MSSDEKTLKAIKFNKNDVSLDILDQLLLPYTTKYIEIQTIEDAFQAIKKMQVRGAPAIAIVGAFAIAVEVFHYLQDKNSGKTVGDLIKDIDYLVTSRPTAVNLSNACNEIKDSLKKYDSSSLIVKEQSDLILDYAVNLYEDDLANNFKIGDNGVEYIKRVLNAENFKGPFSIMTICNTGSLATSGHGTALGIIRSAYSSLQKDVSKEEFFLEHVYPCETRPYNQGAKLTSYELNYEKIPFTLICDNMASALISTLNKSKAIKQSTAPVKFIIVGADRVVSNGDTANKIGTFQLSTISNHFNGIEKFQKIKFIVAAPKTTIDYKTQTGDDIIIEERPANELTSLKGPVIDGDKIGEKLVVGIAPPGISVWNPAFDVTPHELIDSIITEDPHVFEKNSNGEFELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYH6</accession>
    <name>G3AYH6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_101926</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYH6"/>
    <dbReference type="STRING" id="590646.G3AYH6"/>
    <dbReference type="GeneID" id="18245515"/>
    <dbReference type="KEGG" id="cten:18245515"/>
    <dbReference type="eggNOG" id="ENOG502SJ0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013298_1_2_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="61676" checksum="842986FB8B2D65E2" modified="2011-11-16" version="1">MAKDGSLIKLEYDDEFKSAFQRFFEDLFEMLDQCKPGIPSINNDDHYRIARDTDKYPNRDGRIPLYGGHLRENYLEEVVRTEQVLANYLRLDDNEINGLKGSHASFMKKMVKEFPPDLFKFGKYNEFMKGDGIVYLGGDDYNQLALLSIKMLRSTGSQLPVELIVPHESDYDVDLCNNILPALNGKCKVMSHYLPKELISNIQGYQYKNVALLISSFENVLYLDADNLPIQNPDSLFANEPFTNHHLVIWPDLWRRSTSPSFYTIADIQVNPKIRERSSYFNGDKRGENDPISFHDAMGAIPEASSETGQLLINKRVHFSTLVLSMYYNYYGPDYFYPLLSQGAAGEGDKETFIAAAHKLDLPYYQVKEFNREFGPLKNGKHEFFGMGQYDPLVDYIQDTNKDIALTTEFVPDYALNSDDKEHSNYDYHYFKSSSLMFLHANWPKYKLHEMFNHNSYGRGPTFDGKRRRLYEWNIIDETYGFDVELSIMSSLQWLYCEMNINLKKVPEVGSEDRTKICLEINSHISFMISVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYK5</accession>
    <name>G3AYK5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_133299</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684448.1">
        <property type="nucleotide sequence ID" value="XM_006684385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYK5"/>
    <dbReference type="GeneID" id="18249690"/>
    <dbReference type="KEGG" id="cten:18249690"/>
    <dbReference type="HOGENOM" id="CLU_615377_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="445" mass="50260" checksum="EB57EB4A77DAE80D" modified="2011-11-16" version="1">MSKTSDEDWSIISSSSDMEDERSNSGDEIETPSASVPGSTIQAITTTSIDSPLTEYAHNHSYVDDSDDLLAAESSIQTLRLPKTLSTPASLNTSQMVSRGTSANLGLQVPPQRSEEKPVKRAIEFYESLTANTFKLHESIKHQSDKLYHQLTKHQTIEDELDQFETEGTPLSTIKTQTTTDGIQYQYPASQVMSKWLESNSEYLIYFAVFTVASVVSLIKVYTTLTYKEPVPKYPNIWDTIDTFFYDQQVSTSWFFKSSKTKQLKLAKYYDELRIGDMMFLAKNSATQWSEVVVSTASCWLKNADELRKQFITQEKASAVWCEAHKLSNLVTVQSIELSNNLQAKVNKVSVAVDFSSKINTVAEMSEKLYEQYIKNFGRQVGSSLNYLWNDSQRTSAKIIKETLSALKPLSTKVTESSLVHESIEWSRGQIQFITKTALEIWGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYN4</accession>
    <name>G3AYN4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112765</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYN4"/>
    <dbReference type="HOGENOM" id="CLU_3106158_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="51" mass="5311" checksum="3428656389AD2031" modified="2011-11-16" version="1">MGISMGISMGNKHTGCSQTSDQKVPTTGDPNTPLKINPTGIRLNPPCKTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYT4</accession>
    <name>G3AYT4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_112802</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYT4"/>
    <dbReference type="STRING" id="590646.G3AYT4"/>
    <dbReference type="GeneID" id="18246683"/>
    <dbReference type="KEGG" id="cten:18246683"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000036">
        <property type="entry name" value="Serine/threonine protein phosphatase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV65924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="300" mass="33808" checksum="46A7353900F7801B" modified="2011-11-16" version="1">MTSPDEIILAGGKKLTVVGDTHGQFFDVLNLFQKFGFVSDEHVYLFNGDFVDRGSWSCEVAFYLFVLKILYPHSIFINRGNHETNDMNKTYGFTDECEHKYSQKVFEAFAESFGALPYAALINGSYLCMHGGLFSRDDVTLKEIKNFNRFPTSGSTQPPRDGIAMELLWTDPQPEVGRSQSKRGIGMQFGPDITERFCLNNKIRKVLRSHEVRMGGVEEEHNGRLITVFSAPNYCDSTGNLGGVVHFVENPKYNKATDQEDGYKTADDPNCPWSLQIETFDAVPHPDLKPMAYSKSGFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYW8</accession>
    <name>G3AYW8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_101528</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684525.1">
        <property type="nucleotide sequence ID" value="XM_006684462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYW8"/>
    <dbReference type="STRING" id="590646.G3AYW8"/>
    <dbReference type="GeneID" id="18245478"/>
    <dbReference type="KEGG" id="cten:18245478"/>
    <dbReference type="eggNOG" id="KOG4093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103791_1_0_1"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="145" mass="17060" checksum="2C021EC4086D419C" modified="2011-11-16" version="1">MASKFDAEKAENLGDIEMQFAVKAVTQAETYWGLLEKIPGSKLKLTKFDDDIFEQLLIDFPEFKDPSNVVEVQEEEMKSKEGKEKWRAFCEKFNEIEDYNFGTLLRTKCTDEYTQHGTIFVVRIQFYAFEIARNRYGLNDWVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYX2</accession>
    <name>G3AYX2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_112829</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYX2"/>
    <dbReference type="STRING" id="590646.G3AYX2"/>
    <dbReference type="GeneID" id="18246694"/>
    <dbReference type="KEGG" id="cten:18246694"/>
    <dbReference type="eggNOG" id="KOG0426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_10_1_1"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="167" mass="18901" checksum="95BEE7FEF7887C19" modified="2011-11-16" version="1">MALRTTAQKRLLKEYQQLCKDPPPGIVAGPVSEDDLFIWECLLEGPSGTPYEHGVFPATLKFPKDYPLAPPILQFDPPLLHPNIYADGTVCISILHAPGEDPNRYERPEERWSPVQSIEKILLSVMSMLAEPNPESGANIDACKLWRDNRQEYDRQVRQHVQKSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ08</accession>
    <name>G3AZ08_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_101924</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ08"/>
    <dbReference type="STRING" id="590646.G3AZ08"/>
    <dbReference type="eggNOG" id="ENOG502S8A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070610_2_0_1"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="38"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="152" mass="17677" checksum="41E1F8FD68073E9E" modified="2011-11-16" version="1">MTRPHSHSLSQLNKVLPVPISLEDRTPDSSHFLENSHITDVLVGDYHIISGDGGRPYIVWVIRIIINGSTHNSICIYKRYTDIERFRQMLVKQHKDVDIPDLPVKDSMSLQRMMWSSNWLETRRKGLQWFMTNVLLNPKLQHSNVVTEFVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ21</accession>
    <name>G3AZ21_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protein transport protein SEC13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_92334</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ21"/>
    <dbReference type="STRING" id="590646.G3AZ21"/>
    <dbReference type="GeneID" id="18250188"/>
    <dbReference type="KEGG" id="cten:18250188"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV65984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="295" mass="32770" checksum="E71541BF42D1F5D7" modified="2011-11-16" version="1">MVTIGNAHDDLIHDAVLDYYGKRLATCSSDNTIKLFDIEGESYKLVETLVGHEGPVWQVSWAHPKFGSILASCSYDGKALIWKEQPETRQWSIIAEHKVHQASVNSVSWAPHELGAVLLCSSSDGKVSVVDFKDDGTSSHVIFDAHAIGVNSASWAPITSVDSKSPTPERKFVTCGSDNLAKIWKFSAKDNKYVEEARLEGHSDWVRDVSWSPSVLIRSYIATASQDRTVLIWSQDKSGKWQKQLLTDEKFPDVCWRCSWSLSGNILAVSGGDNKVSLWKENLQGKWESAGEVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ40</accession>
    <name>G3AZ40_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_92350</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ40"/>
    <dbReference type="STRING" id="590646.G3AZ40"/>
    <dbReference type="eggNOG" id="KOG4073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081974_5_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="165" mass="18625" checksum="EEF900DD3975B1F0" modified="2011-11-16" version="1">MPPVLKRLTSLAPPLTTKAIIDELRLVNSGDYKPWKLEHTTNNEDKPTSFLSAHYQLSSFAKTWLFLSEVAREANKTKHHPTIITTYNKVDFKLTTHDAGNQVTNKDITLAYAIRDIFLQVQVLPGKSKSFESFLKGISERSMLSEASKTIENLMSAKDSKQNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZI2</accession>
    <name>G3AZI2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Not1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_117969</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AZI2"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000286_3_1_1"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032195">
        <property type="entry name" value="CNOT1_HEAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16419">
        <property type="entry name" value="CNOT1_HEAT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat 1" evidence="11">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="10">
        <location>
            <begin position="440"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="648"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="8">
        <location>
            <begin position="964"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="12">
        <location>
            <begin position="1236"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="1573"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="899"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1154"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="929"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1184"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1941" mass="217766" checksum="E357B435A6C19F44" modified="2011-11-16" version="1">MSFKELLIEVNKDLKGINPGNLLPVMLKIDKKEIDSSLALVIAEVISPGSTNLPSNPLKGLSTCKSFPESSAKGAQLQTTFKLLDSDPAIKIDWLLVFSKAQETLSASKAVAPSFLNINQFIAAIDFRPGLLDIALSVDWSFSNVLLYTLLTADPKQGCYDLGTSPFLTRGFDDVETPIESQLGRRTPIAYINVGRLELKVVSQYAASKKPLNEKSIDSEISKLFDHHCHTFPEYMLCACITFVNEGNPFIEGVLNNLLDTLLTNESKFLRNVIQKFNEREQGALMNKLFNYYNLRKNTDAILTISRAMLQSNLFDSLLTQFLNINITMGLNLAICSSVLDFDCKPLIDSLLNDPNKRPIVVQAILEILEVKSTEDTNLITKTKVLGVATVFHLLGILTRHAGFLNGEKLKALQLQLLTTYPRLINFGCGHDGAILENDKVSNVFPEPVEQEMKAYYSKMYNKELDIKEIVDMLIKFKSSDIPHDQDIFACMIHSLLDEYRFFSEYPLTALASTSLLFGALLQKDIIQGTTLTVALNFIWESCNQPQDSHLFKFAVQALYNFKSRLHEYPNYCKHLLECNSLSAHAKMYQIVKDASNGIPCDDQSFNGSRPDSSNSSGQPMSINKSTEDGGIKYQSITISDQIIGSIQQEKPNENVTDRLLFFVNNLTGDNLNSKLPEIKDYLIENFFLWFADYLVADRAKSEPNNHRLYCELVQEFDDPIFYEYVLSVSLREVSFLIRNFKDTSLERSHLKNLGSWLGQITLASDKALKRTHIGVKFLLVEAYDFKTLPYVIPFVCKILDQAKYSKIFNLPNPWVLGIIKVLVELYDCADLKLNSKFEIEVLLNSFNMKISDVEPSTIVRSHPPNPAALAAMFGIQQNANPLVNDFSKLALDGQAHLPPAQFQPSQMSQHQGSEDGGIPSLSGQIPPQGLPQPKPQGQPKPTAGGLDTSFSTLVGNTIFTTNPNLRRAFQASLSRAVRECAVPILSKTSESVITTTEALIKKDFAYEGDINKFRKSYQSLAVKLAQSIIGSSGRKILIETIQAFMVRLLSHQLNPNDIPLGELSSAIQSNVDLCVDIVNKLAVGNIIELIEEKMKYSVLEREQNQPGQRFVEKDANGYALNLQPPLGLKPEGLLPSQLAVYENFSASIVRPEVVSQPQAPPQPQGLQSLGQPQAPPTSALLHPPQQQQPGAPGLPVPQDDTTAITDQLFAAITQSCDKAISSLADNYTTTLAEIPQDHVIMQCITNVLTLAQGNALKYPELLLKVAQYAVNCLFTQAHENPISNEIYVVILDKLCEYSPSTAKDVTWWLVHSSDQRKLNISVMYSLLKVQLIQPTKLDTSISKLITETKNPLIVTFAANLLGIIYTSKDPRPIALRSEFALSLASLSKYEGDQSIEGTKEAREARDKLFELLNDNALVTANSEMYSQLGYIFTEWFKLLTHGDCNEELKDEFVKGLFKTEILTDPELFSMFFKSAIEVSITSFAMEHDIRSRTQHEALLVVDALAALIVHILIKFDKNNVEDAVEYFKNIMGVILVSFTNDHESSNGQWSERAYFKFFSSLLCYWNDASMMQVDATVHMDIQFFNFVGDIFYSLQPIIFPGFTFAWISLISHRMFLPRVLELPNKTGHGILVKLLTPLLRFESIYSVDESVNYDVICVIFKAINRIFVGLFHDYPDFFSENYLQLLACIPASYIQLRNIVLSATPKGITLENPFKRGLKVERISDMKKAPIIFLDPTEDIVKSGLRRPVDNYLRIPGPGLIKAVYNGLKLSKPKQVKEFEFDSVNYNVGLINSLVLYVTLSEGQENGGAFQPKDAHVSIFFDLLSIGSTEFKFHLINALANQLRYPNTHTNWSVGLFLHFFNAKTWSNSESRITVQELITRVLLERHVVNKPHQWGLTILLTELIKNDTYNFFELPFVKNSPPEIKLVFDSLYTNITTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZQ5</accession>
    <name>G3AZQ5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_133526</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996513">
        <property type="protein sequence ID" value="EGV65578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZQ5"/>
    <dbReference type="STRING" id="590646.G3AZQ5"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080471_0_0_1"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="301" mass="33040" checksum="B573033E1DAE838E" modified="2011-11-16" version="1">MDHDEDSEESPSTPPKRAKRGRKAKVKEEPESPPSSADDKDDKRNPLTEDEKRKHFLERNRLAASKCRQRKKQMVAKMEDELKFYAVGYRDLSGQLAAMRDHLHRIRSVFLNHKSCPSLVSQLGGYTEMNHFLDQLDYITSISEKNSGNLVSLPTTIPTTLGSTSDNYVVPPAPTSTIGHNLPMADTSGANSVNGYDPVSNNISAHHSMTNLQAAGAPGQATTARGGPDGGTNIHQPQATDIRTINSMSDLASLNQNGNIPMNDPHHPDKNFGLRPVNSMVNLHPMNHHQNGLVDLSNDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B041</accession>
    <name>G3B041_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113033</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B041"/>
    <dbReference type="STRING" id="590646.G3B041"/>
    <dbReference type="GeneID" id="18246795"/>
    <dbReference type="KEGG" id="cten:18246795"/>
    <dbReference type="eggNOG" id="KOG2626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014420_4_0_1"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="84"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="408" mass="46300" checksum="CEE9357D5706F743" modified="2011-11-16" version="1">MEIEPQVKEEEKTEIEVQAPTHTLTKKRRVIVEPRLKPVSYKASDLKVGNSISRTPAAIINSMQFFTNEDNPLNRRGYKYKPCKPNPELKSTMYSTTDLPPYCVRPSYFDKSSGILLDTNVTSVSNTSGWRSIRSNVGVREGKWYFEFKVLSGNDGTGHVRLGVGRREASLEAPIGCDGYGYGIRDVNGQKVTLSRPKPFMDEGFKTGDVMGVLIDLPSLEDHYKSFEQELKAAENKFNVHGNIVRDQIPIKYKSSLYFEQFEFTPIENMTKLLNPIKVIGERLSSFDEDIQLPKIPGSSLKVYKNGKLMGTMFEELFSFLPIPGNLAQIQNQSFRDCDDGTLGYYPMISVYNQAVVEMNAGPEFALKELPQGVRPLCERYDEHVVEQWYFDLVDEVESQYLDGLEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0H8</accession>
    <name>G3B0H8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_92628</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0H8"/>
    <dbReference type="STRING" id="590646.G3B0H8"/>
    <dbReference type="GeneID" id="18250213"/>
    <dbReference type="KEGG" id="cten:18250213"/>
    <dbReference type="eggNOG" id="KOG3122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056234_0_0_1"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41548" checksum="15D4704D0FBE342B" modified="2011-11-16" version="1">MSNRLESLNTKQPGAVKPSLKFKPKAVERKSKEERAKHVQVKQEDTSDRDKFKSAKPPRGQRPARGRGGRHNQYANTHVLSSGLLSSGAVSGGFAKDTKVVNSASPSPDFLSNLKLKQPAELARVSASESDDEGDDGLTKIDMAKQYRFADEETVLFPVRPVRDDSEPPEVIALGVSKEPSPVKEEPLSTNDVAYSAQTELQRVLQTKANLESKISQPVDMLSQVEAKKLAEDHDHIAQLMSRSFESNDDKFSLFQLPKLLPEYSPKSKEDKAENSKLNGQIGHLNIHKSGRITINLGNDINLDVTAGIPSTFLQEFVLLDLTPAPESPRIKTEEDMDIDAGIEINDQNNDNDEPKYQGTINKLGEVDGKFIATPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B127</accession>
    <name>G3B127_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_103514</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B127"/>
    <dbReference type="STRING" id="590646.G3B127"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011502_0_0_1"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF384">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="92440" checksum="A1ACB3EB023A9852" modified="2011-11-16" version="1">MSLPLLSGRSAVFDFVSDQHEVLKQKRSLKLNSLKTHLPNLSLSDIFEYLYQYINSYDPPLEIESISLAANGLESFPLNFKLLTKNLSYLDLHNNNFSELPQDIYDLTQLEFLDLSSNRLFHLSRSRMGQMVNLKLLSLQNNKFRYLPPVLGSLPSLNLIEISDNPLVQPSLEMIQRLQKQSSEHEWVSQLKSYLISNAAAIESKIYDTPQPAPRSTPSASTVSTSSTPQASRSKNISETKTRASKAARRMGLIIKKPDEISSNQSDDSRDTDQIDFASPLTFPNSSSSIDSSFNLVSPPPAVGTTTVSTLATASNSDGGDSPPATPTISAPPSRPTARPRSRSNTLLEIDRMLENSDGVDTEHKSGAYFRRLSTLAEVPVDQNLPYRFHQTHSSISNGSNPSSRNGSPFGSSLSDLSPSKPARKYSESDTNSLIGVSRKVLFAFSELHSSVRRFSGFCSDKKVTIKMVSFLYSAKANIDTLVENLELMEENSNNLDKIFESLNTCIQSFKSIMGLLSDNFASFVNKIDICFIRMLYLTVYGSFNEILNAYKILVPSASFRVQDKPKMGLSINTTSESSDEVDAKLYESIEIATSKAQDVYGELTRAISKSAIASANSNSDSSSSEGAIGPQVAVKVKELTSVCVSSIDIIKRIKTKLITIRNDPNYSTKKLFWDDINLFLKAIIQTFSAVKNLMKDLPILNEIRSSMSTLTKSTKDVTILLEASSYKSISNDYNGSGVGPHPPPLSAIPSVSNIFTPLSAHPTVSSSHTNLPQAQGPPQMQSHSTLAASPILTPSMSMEGPHPSQSTGQYYASNGMNPFDGLIMVNSERQSERERERHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1B0</accession>
    <name>G3B1B0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_134232</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1B0"/>
    <dbReference type="GeneID" id="18249782"/>
    <dbReference type="KEGG" id="cten:18249782"/>
    <dbReference type="eggNOG" id="ENOG502RQ6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_980040_0_0_1"/>
    <dbReference type="OrthoDB" id="4087050at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442474" evidence="1">
        <location>
            <begin position="17"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="284" mass="32428" checksum="E9A00DD03CF63A65" modified="2011-11-16" version="1">MKVYPLLCLFTLVCCSIPISQRYKSSFKVLERSSLESNSQAKQQQSSMVSFADKAIKFNQLGSSNGIVNQLKATEYEPSMSEDLKVAQSKVRTSTFTSSSESSVPTKFVLSSARNFVQEFLNFKQQQVLSQAVKDPNPKLETSFISYEGSLNDPENLKEFTNRVVQESQAGRQFSDYSFRRFGDQPVSKVKKLNFDPQFEMPDLVDYLVKYEGFKRQDLACFIETELDYGLEEIERELNKIKDNQREREKNINIGGETSDAAHTHKGHTFIYLLAVIFAVSIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1C3</accession>
    <name>G3B1C3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_93171</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1C3"/>
    <dbReference type="GeneID" id="18250260"/>
    <dbReference type="KEGG" id="cten:18250260"/>
    <dbReference type="eggNOG" id="ENOG502QTA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020175_0_0_1"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF39">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="663" mass="76153" checksum="2B7C0244A9C57B04" modified="2011-11-16" version="1">MVSDNKSAIDFERRSKAACVRCRKRKTKCTGEFPCSACVQTKSECVYPRKPKRISVLDTELESLHKKVKRLEEDLKLEKLLHSDPDPSQKNWKLSVLLNSPSCELICWNLINFMKSTDEDITISPDFNFFIEEDTYDSVLSQQAALGRSPWEVVQVLSEISLFEVESCLKKTSQFMNTGYMTINPVEFRNQLQYYYSPDGVFTYRKVDSVDYFLLKVLMIVALGNVYDEKNCLSPGMPKVELPGLKYFKVVSNNLPSNFQLITFEKKNISSIFEVIELFGVVSIYCRILDKKSASCFFTLTALQLCVSINLHKDTFLSRTNKRGLDLLPNNNSRAIFWSTYCLNRFYSTRIGHPLLLSFKDVNVQFEKDYGSSDGTNKNFYETNDDIKHYIKLAQISELINVDVYNNKRKSSEYISTLFSILSLLKDWSENLPPHLQLDGNLSLSAPYSRALSSLHLNHLHHVYLTCIPISLHLAKLKISHYNKTGRLRKLELSSLPLNVQNLLIYCQQSCQQTVNIFKSLYEKKLVTVFGFTDIDYLFSVSAISIICVILDYERDDRTPASFEDNFKTCTKILSDMGESGNRIAEAKLNQITRLVEVLDPILSQLEYSLDKTSEVPVFDPTESNEMFSFVDVSQDMDQLFKLTDADLSFMEALLNEYDTILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1D9</accession>
    <name>G3B1D9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="9">DMRL synthase</shortName>
            <ecNumber evidence="4 9">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113693</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 9"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1D9"/>
    <dbReference type="STRING" id="590646.G3B1D9"/>
    <dbReference type="GeneID" id="18247087"/>
    <dbReference type="KEGG" id="cten:18247087"/>
    <dbReference type="eggNOG" id="KOG3243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_2_2_1"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000007">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="161" mass="17711" checksum="F284D5B1417F3934" modified="2011-11-16" version="1">MAIHGLGEVDQQYDGSELRIGILHARWNKEIIESLVKGAHDKLTELGVKPENIIVESIPGSFELPFGTKQLSEKYEKLGKPLDAIIPIGVLIKGSTMHFEYICDAVSKQIMTLNFDLNKPIIFGVLTCLTDEQARQRAGLGGHNHGADWGAAAVEMATKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1G9</accession>
    <name>G3B1G9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="14" type="ORF">CANTEDRAFT_121225</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1G9"/>
    <dbReference type="STRING" id="590646.G3B1G9"/>
    <dbReference type="eggNOG" id="KOG1314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027721_8_0_1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="77"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="414" mass="48793" checksum="368DC7D27183042A" modified="2011-11-16" version="1">MVAQLRWPILGIIVPCVLIAGIGYGSHLFVLRHSLSHQKQIAFEVSLSLLWISYLFAIHVDPGYPPDNFEPRPGEWRRWCKKCQNYKPERSHHCKTCNRCVLQMDHHCPWTYNCVGAKNMGHFMRFLFWILVNTGFVFIELSKRAMEFYEDRNLPAYLIDKKELVAVIVLLPLDIFVNFAILILFVRCLSNWVFKGMTQIEQWEHERIESQLHTERMWLQIRKNYIHLHGHEMPVLTSWNQNARFYSEDRGSEEEADELDYVEDVDNASSEYHQKTSVVPQDFTIDDFVFPYDLGIVKNAINTFNYPWMWLFPWTSVRQSGYRFEKNEYAEDDQVGLPWPPDGGHQEYAPDPDIDLDNLDVSELRNLRQLKKRLDPRSKLDRKDWVNGLGETLGDYGVDLDAEDVENDQLVMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1J6</accession>
    <name>G3B1J6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_119931</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1J6"/>
    <dbReference type="STRING" id="590646.G3B1J6"/>
    <dbReference type="GeneID" id="18248739"/>
    <dbReference type="KEGG" id="cten:18248739"/>
    <dbReference type="eggNOG" id="ENOG502SMTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_1_2_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="584" mass="67662" checksum="36379F346CBA568D" modified="2011-11-16" version="1">MFMILQDDTFSITGKKQPLKRKDGDKYGGKVKSIVGTKFRTRTGCLTCKKRKRKCDEHHPSCNYCHSRGVECVYVNTPLQGTKPIRPESDSEAPKIQQIDHSEPPLYELLLTDPSFNQTEQSLISMPSPVTEKQLNSDLEYIENILNEPNDGTLIKLHEDPTTNEDQFEYMISPTSLHPTAFPSLFLDDEGRSYFEFFHVKVSKFLALSDGPMNYFSNFLCTLANNEESFLYALTSWGALYAGHDDTKVKVYLNKALNTFDNNFQAKNPSEIYFRLCFSVVLIGYYVCFGEVVTWKGIHDNCCRILKDLGGLYKFGKLYGFTNEARFIISNVQYVDVMSAYNHKYGTQFSVGEYKEFLGCNEIQRNELSYGIDTLQGVHQSIYLVLADLMNAKVELNKKLKELQMFSDTDEHRFYCLKEELYQMYGTVIKKLETSIEEAEPNYSLLELIKDQPQEHDAYLNSFKLYQSTCRLYFKLFLKKIPPKNMEIQLLVREVYEAAEKLENTRFCVILCLPMLMCGVCCVDKFDRETIEKKIQRLKQTSPVLNNHKTWLLILKSWELNPCGEFVVDWADIADEYGWFLNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1M6</accession>
    <name>G3B1M6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_92715</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1M6"/>
    <dbReference type="STRING" id="590646.G3B1M6"/>
    <dbReference type="GeneID" id="18250224"/>
    <dbReference type="KEGG" id="cten:18250224"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008578_0_0_1"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="296"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111174" checksum="B693116809AFB255" modified="2011-11-16" version="1">MSYLPPNSPLFTSSQLAPVSSTASGDQNLIPQLPEKPTASSGTVQMYIIPTEKNLFFQGFEANEYAGRQPILLRGCLFIRILKPAKIKSISLQFTGSLRTDWPEGIPPKKNVFSEENNVISHTWPFYSMSNPLNTLDGGADLYSELPKNIDRDVSHLSLNDSSIRPHSPSLSQLETTNPGLFKTGLMKKANTSPQLHPVDSFNDLSSVLTGENEVGKPGTFPPGDYIYNFEHPLRPSLPETTEVTFGDVSYELEATIIRAGAFKSNLIGKMPINLVRTPSEYNLEENEPIIISRDWEDQLRYDIVIGGKSIVLDSYLPLAFRFVPLWGKVALHRIRVYLSENLEYYCQNKKVHRMEPSKKYLLLEHKAKKGKSLLTKKENGEYGDETEELLPRELEFQLYVPQNLNGRVNHVLHPDTSFDEIQAHHWIKLCLRISKLDPEHPEKRKHYEISIDSPIHVLSPLAAHGNTLLPAYNEFLPEFLPEYTPASPPLSPEVIPVESTATIGKLFSALNPVSSNSSHKHETPSAVHSPTPEIFHHINSFDNNDDPIERDLDMHLEANLYKPDPNESRSQLNSPQAMPHIGSLSPVTSPMLRPIAPLVVPSKDPPPFEAASPPPDNEVPPPAYEKDSARNSMSPGVTRDSSTSSLLPRGRSKTNSSTNTNGSNGSYGASNEISIKDLLTNSLGGHRNSVASKKSQSSGESDKSKGNQSSSSSLVKSKGIVPDSDNTILSPKVEHENEHESEEDIVNLIGSPELIPEAVSPRRNLSPMGSPRTGVSPIASPRRGISPISTPLRSRSPERGGTSPTQSPERTFSSDALPPTIQFNGNEEHNGHKRESESPGYQSEIESSSSRRTSIASFSSNEMQMGQNIPLLSSSTQSLLLSNPANTRTASVGSILFDPGRRHSSNTRPSIVDFVDGGDLGGDFFRDSMRLTKLNNPRRHKETNISEEVIESDHLTKNEEMVHEEESLTGTSESDLTVNENQTLKTQSPARGPTKEIPGFKIGFSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1T9</accession>
    <name>G3B1T9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113297</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1T9"/>
    <dbReference type="STRING" id="590646.G3B1T9"/>
    <dbReference type="eggNOG" id="ENOG502QVFG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482420_0_0_1"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="66923" checksum="4DD5B1F4AFDDF17A" modified="2011-11-16" version="1">MTTSGKGPFNAENEITKYKLDHSTFDLINVDRFKNTNWSTVFAYMWLWIMIFLSWILLGVDIYTCLNILVFHKWSSDDYKPYAYSVAKWLFTGCIIFQFILLAYHLVWAIHTYRTKNIALAYVNSIARTMYSVKSYNYHCLFHKIDTDNFFDWACFLSYGEVDNALQILLADTPRQVINILTLRYYATDGDLSNDIIANIKKIADTNLRLSIILSFMCLSVIIWSIFFFKFCLGMVMYLPVIAKLRNKGTKSLKKYCCKVVNDKVRLLVLKNHKPKSELLEQGILDMSEIKANPLLNDTVTRFDTDNDYEYQAVDRGVPSYNDNNKLYSSNAYSLQDLSNPFGDQDKASIGKDSLASDSSGTLQEGIDFSENSAKLATSSAFYGSGSGSRYTEPYQNPFSDSNAVLLQGRNMSQSSLTYDPFEPRLTQPGRVQTQPLPHLPRNYSQGTPAPEYTSSSVNPRSFSRKSPPNLDFPPKRSVTEGDLVRSVTEGSVASNTPYPVRGISLYDKNRKKSDAQGTTKSAGMYPSQDTGILFTIFPTPTPYDTFYKTIALLINTFILQINLYTKMILSSTYFPAFFSSCSFFNLANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Z0</accession>
    <name>G3B1Z0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-arabinitol 2-dehydrogenase [ribulose-forming]</fullName>
            <ecNumber evidence="5">1.1.1.250</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113330</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; D-arabinitol metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.250" evidence="5"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685370.1">
        <property type="nucleotide sequence ID" value="XM_006685307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Z0"/>
    <dbReference type="STRING" id="590646.G3B1Z0"/>
    <dbReference type="GeneID" id="18246904"/>
    <dbReference type="KEGG" id="cten:18246904"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047038">
        <property type="term" value="F:D-arabinitol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000240">
        <property type="entry name" value="SDR family oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF115">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="277" mass="29914" checksum="5475C1C141313BF8" modified="2011-11-16" version="1">MDFSYNNVVPSFRLDGRVAIITGGSGGLASVISRALLAQGAEIALIDMNLERTTQAAKDVVQWGEEELKGASFPIGQVTAWSCNIGDYPSVEETFAAINEKHGKIADLLINTAGYCENFPAEEYPAQNAEGIMKVNGLGAFYVSQAFAKPLIQNNLGGSVILIGSMSGTIVNDPQPQCMYNMSKAGVIHLARSLACEWAKYNIRVNTLSPGYILTPLTRNVISGHTEMKEAWESKIPMKRMAEPKEFVGSILYLASDSASSYTTGHNLVADGGYECW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B219</accession>
    <name>G3B219_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_103277</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="4"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B219"/>
    <dbReference type="STRING" id="590646.G3B219"/>
    <dbReference type="GeneID" id="18245616"/>
    <dbReference type="KEGG" id="cten:18245616"/>
    <dbReference type="eggNOG" id="KOG3148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049611_0_1_1"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="252" mass="27849" checksum="32DC2CE396A023AE" modified="2011-11-16" version="1">MRQAVFSSPDEASTYVASYISGKINAFNPTPSRPFVLGLPTGSSPEGIYKKLIDLNRAGKVSFRNVVTFNMDEYVNLAPSNDQSYHYFMYNKFFNHIDIPRQNIHILNGLATDTEKECADYEAKIKKFGRIHLFLGGMGVEGHLAFNESGSARHSKTRKVSLVQSTIEANSRFFNNDLSKVPRHALTVGISTILDNSDEIILIVLGKAKKEALEKAVNGPKNDASFPASYLQGHPNALVVSDFDAAGIKYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B248</accession>
    <name>G3B248_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113374</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685852.1">
        <property type="nucleotide sequence ID" value="XM_006685789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B248"/>
    <dbReference type="STRING" id="590646.G3B248"/>
    <dbReference type="GeneID" id="18246924"/>
    <dbReference type="KEGG" id="cten:18246924"/>
    <dbReference type="eggNOG" id="ENOG502TBA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036640_0_0_1"/>
    <dbReference type="OrthoDB" id="4091783at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="48766" checksum="90145F42B1B397BA" modified="2011-11-16" version="1">MSLSTTAPIETYMSRSWLRQHLYYLGYDIIRLQSYQKLSRHIGTTTGGFIKSLVSDISTFINTELNESSAGTEAASKLKELMYLHNCDHAIKGEINANISECRLFFMSAGYILLNQTSEKVDEFTDRLISIYMESKESVLTRRVTQNDSLTTRVVELANAYYEDCDVNYDLLYNNKPRSLNLFVTKHISIELPPLPKLHNRKLLVKSLVHKELYRGFVDESHRFYRILMENGIEPREATQIIRNDLSFFDGLGDFYLSQESSNLLYRFKHSAPYKNETFFGKKSYTLLKTILVTNTLFSRLALAYNLHEGLDDPIVNGLFRDTYVPYLNDWKDVDFDTCQEFKTYRYEQEFIADYFEQYVGTLFLEQPKTAQIWINQIYENILFSIREEHRVPSKFLHQYDYHSWAVDVIGRRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3B298</accession>
    <name>G3B298_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_120381</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B298"/>
    <dbReference type="GeneID" id="18248773"/>
    <dbReference type="KEGG" id="cten:18248773"/>
    <dbReference type="eggNOG" id="ENOG502QW6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009418_0_0_1"/>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="524"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="759" mass="85995" checksum="8A4F7F818821A235" modified="2011-11-16" version="1">MAREKRTKPCFNCKRSKVKCIYTDVLPCERCVKTGQSSGCTFVPKLPNLRLPVINTEPTLYNGLNPPRHQPVQHHNNHPQPGMVLPPLTPISTSGPVTGPLPQAQKTHHIRRGVSLIPPKDQHSNDSQWKNQMEDKMNSFDTKLNDLVDVLRSNQRLLVQQQEQFQLQQNSNLELENDTNMNSSLSRQISSESTYSSRSSDNENVSKRRKLTDDVFNDFRNDILTLDEAKDLFHFFDKNITPQLFGFEIAKFSVDTMWETSPILICAICTISSMHHPNSSLSSRHSMLSKHLHKLCGDLLYQGRPNTEVDAFNTILALIFCSFWLSDSQMFTGLALQMAKEVGLDRTDHSHHRNAPGTLNPKDRLKLWYLLYILDGQQSLTYNRQPLVNSREYSLQHSRSLLMPNDKTISSGENHAYLLPETEPEESKEEHREQPPSPTFTDMRIVSQVEYNQALSGAFAGNAWDLLTPASLGIPSKSNLELDKWMVSWTVLLSPMNNGAVWSSKSTLIYYNFAKMHINSSAVRQLQAKNPRSDNEFPKLDQLSQGPKRPEPPRPNTRSPVEEEKDWEDSSDDDEEFISNEELVHKDESTINANIAFTAAQTVLNLVLNDKDIKENLKYVPVHVHIMLYYASLLLVEDRISLEVDDDLASSFKKSIINLGTLSSLRQVISDNFPVDKNFGERLIISMDELIGDRTAKLKVSILDSDIDKTIKQKLAAQLSSVGETVSTKFELFEEKSTRGSSPGIYAWPGSNHGHPSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B299</accession>
    <name>G3B299_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_120384</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B299"/>
    <dbReference type="STRING" id="590646.G3B299"/>
    <dbReference type="eggNOG" id="ENOG502S6U8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_1_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="162" mass="17683" checksum="69451EE8AF84C118" modified="2011-11-16" version="1">MSMKTKIKQFFGASRQYAVSGASNDPSKFGFKITRWYVSHNLPVIPVNPKASEILNQSVVHSISEIVDAIKSKTDIGEHALSGADGLSISFLTPPKITTSTLKQIAIVDGYKGIIKGLWFQPGSYDAEVLEVAQQIGLFDTVVYEDECILVRGEEGLYSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2L5</accession>
    <name>G3B2L5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_103422</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2L5"/>
    <dbReference type="STRING" id="590646.G3B2L5"/>
    <dbReference type="GeneID" id="18245624"/>
    <dbReference type="KEGG" id="cten:18245624"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037637_1_1_1"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="126"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="244"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="286" mass="32190" checksum="CC434FED0A267EB4" modified="2011-11-16" version="1">MEAKEIKSIVSNLEKSSDDVMILKLLNILSDGVKPTEKLLRETKVGVAVNKYRSSTNSEISSIVKKMIRNWRDMVQAEKNKKKGPTSDVKAATSGSSTPSKENKFHSGPRNPKIDGISTDIYDDSTRNASISALYTALAIERGDSSQQILSVAKSIEAEVFKDEYSKVADGYRNKLRTFVMNLRNKKNPELRDRILSGQITPGKFVKMSPNEMAPETLKKEIEKLHKQNLFDAQGATEKRAVTDRFTCGKCKHKKVSYYQMQTRSADEPLTTFCTCENCGNRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2V9</accession>
    <name>G3B2V9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_120759</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2V9"/>
    <dbReference type="STRING" id="590646.G3B2V9"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_1"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="218" mass="24531" checksum="3A47219DFF873585" modified="2011-11-16" version="1">MSTSTNYSKNVILLPQTNQLIGLYSIIRDQSTRRGDFVFYSDRIIRLLVEEGLNQLPVQKTIIKCHGNHEYEGAKFLGKICGVSIVRAGESMEMGLRDCCRSVRIGKILIQRDEETALPKLFYEKLPEDISERYVFLLDPMLATGGSAMMAVQVLLARGVQADRIFFLNLLAAPEGIQTFQNKYPEVKIITGGIDQKLNDDKFIVPGLGDFGDRYYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2W1</accession>
    <name>G3B2W1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_93013</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2W1"/>
    <dbReference type="STRING" id="590646.G3B2W1"/>
    <dbReference type="GeneID" id="18250246"/>
    <dbReference type="KEGG" id="cten:18250246"/>
    <dbReference type="eggNOG" id="KOG1781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_3_2_1"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000098">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="35"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="129" mass="14469" checksum="F4364B060C8C1083" modified="2011-11-16" version="1">MESKETARDGNQNNRDHKDQRRRNNGTKQEGPKREAILDLNKYKDTQIKVEFIGGRQIVGVLKGFDQLMNLVLESVEETLRDPEDPNVLTKDTRSLGRVVVRGPSLLTISPLDGSEVIDNPFVAAEVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B316</accession>
    <name>G3B316_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_105496</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B316"/>
    <dbReference type="STRING" id="590646.G3B316"/>
    <dbReference type="GeneID" id="18245816"/>
    <dbReference type="KEGG" id="cten:18245816"/>
    <dbReference type="eggNOG" id="KOG2149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050252_2_0_1"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="8">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="299" mass="33610" checksum="CCA2926FCBE47677" modified="2011-11-16" version="1">MGSKKKKQEKRKDFVKQRLKVGKTAKAANFTDTSFKSKGISLPNQAIGAKSIEQYISLTRHHSFSTRKEVLVMLQKHIPNDPKLKQQLIKALIPMITDDAKEVRDALLELMKMLVDTNMALVEVNSNQLILYIHSAMNHINPSVHNGSVGFVNLIVDNFPLHLIKSHFVKTLDGYFNLLGWTKTNNKSVSSVSKKNLLTHLASFNKFLDVSLQESESSDKVHYNALTHLYTFPTSGNPFTQLNLFSVLNGSSTDLVSRKKVIVETYKPWILFNSKSLLNDTAEVSRLAQCIVALVEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3F8</accession>
    <name>G3B3F8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114187</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3F8"/>
    <dbReference type="HOGENOM" id="CLU_1304707_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="211" mass="23990" checksum="566FD4D6E25EB7F2" modified="2011-11-16" version="1">MRDSKTEFTLKVPFYHQNALELRNILSEETFKQARFIRKNFKPDLTPNPKYINLFKDPFEPAEDNDISYFFLEEFGIKLKSAEVYQQLPSMEKEITPPKEVIVESMVEVSDNFDPLGLGFSLGGIGSLEEEKDVKNEEEDIKEDAPISVEETDVSFTLTDNEITTQKSQVIDLTSDPQNITQSSEPSESESVSKRSADSSSQASKKVRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3G2</accession>
    <name>G3B3G2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sec1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_122388</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3G2"/>
    <dbReference type="STRING" id="590646.G3B3G2"/>
    <dbReference type="GeneID" id="18248900"/>
    <dbReference type="KEGG" id="cten:18248900"/>
    <dbReference type="eggNOG" id="KOG1302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398604_0_0_1"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="71084" checksum="4AD97B3CBA05B837" modified="2011-11-16" version="1">MDAHSLNNATINELLSIFDQIYTHNNLLVLDNKLSPIINFLLPFKVFKQRAKFDKITLSDSINHEVIQQYQNIIILFDEDTPISIPEHARVTIIIKNLTKSRLYELNQQYHFGLSFDEIIENKLDMVRAKTLKIYNWQFKGIEVDPDIISLQGSLAQYFDEPIYQVNQLANALVNLVDKFNIKINSTYAQGSNSNIFTGLYENKLQEHLAQKYNNLQQEFYSNHLTPTHNLVVIERNLDFLPVMMSQLNYVGLIDDLVSININLVKIVNDQGKEEQIKVEDELFENLKYLNFSLVGPKLNKLAKWIKNQYTNNSSEMNLKDIKKLVSSLTDLNRQQDLVKKHTNLSENLLNKVKNGGANRYNEYEIVLEFENEVFQLTYKQQISKLLEFLDLNLSARTIINSLVIVSTINSGIRSRDYEQIKQQAFENYGITIIYQFEKLFKYCLVRLSDVETLDTYTAGVTGGINVHNNNYTLLNKFWNLHPEEQEDDQEINGIEDYPHPSFALPSATVPLTIRVIESLFVRDFLTYKPINKITKQPSWQNLGLDKMFKGKVSETIGDATVKNTILVFVGGITWSEISCIKYLNHKLQARELNHQFVVLTNSIVGNRQFGDSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3H9</accession>
    <name>G3B3H9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114216</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3H9"/>
    <dbReference type="STRING" id="590646.G3B3H9"/>
    <dbReference type="GeneID" id="18247317"/>
    <dbReference type="KEGG" id="cten:18247317"/>
    <dbReference type="eggNOG" id="ENOG502QV1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_0_1_1"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="598" mass="68172" checksum="D83EA24C2B7B3C08" modified="2011-11-16" version="1">MVRFGSSLTSQPTEVETKIADTSDPNRSPFFQYSWGSWMKNDAIEKAKRQTRFSIEGTTKLVQLLFEHYSAENNNFKVQTPKSLADGSVILSHNLSLVGKSDGSLSVKSISSIHEGKSNRIYKISLSNGTELVLRLPYKLESEYSIGEKIKSEVATNDFLSLKLGLKVPRILSYGANKLNFLQSPYILMEYIPGDLLMKQWEPLITDEVPDSKQKLEDVIKPIADFQNATNSVVFNKFGSLYFTADVEGYLQSDLPYEGESNELFVNRWRIGPSVEKSFLRNKNKLKSKQITTHNGPWPSDQPEAVIASIAKIELENLTTRLGLAEADSSNQVENIQNLKNSIATFENLAKMAPLLLNKASKSIPNVEELFKPRLFVPDLDPLNVIANSDRNNELFFTDFEYSSIKPFVLFNYPKFVAYSGVKIYNLEEDIPNFKELDELEQQQYQFMYYKTRNERLWELELNKNRHDLIAVASPHVKVLKSPYLQALEYKSDRDYLYVEGSILQLKGLWEAYVANELCNAQTPEFPIDYTPEVVEQFQSDLQAYQTEISSTPFAATGGWVPQDMFDQLKDGGLLKQTPDGYEIETEKLLQQEQEANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3M1</accession>
    <name>G3B3M1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NTF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114251</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3M1"/>
    <dbReference type="STRING" id="590646.G3B3M1"/>
    <dbReference type="GeneID" id="18247335"/>
    <dbReference type="KEGG" id="cten:18247335"/>
    <dbReference type="eggNOG" id="KOG3763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024991_1_1_1"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040736">
        <property type="entry name" value="Mex67_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18444">
        <property type="entry name" value="RRM_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="9">
        <location>
            <begin position="311"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="10">
        <location>
            <begin position="548"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="494"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="600" mass="66558" checksum="D9FDA959CF03F09F" modified="2011-11-16" version="1">MSYRGRGRGGFYNNNRGNFNQNQGQGPNTNNVPTSQNINQFISGNSIPVEILGWNGASMEDCVKFISRKCRIVVSNASIDPQSGAMKGYVKSQKDADDLCNWSGVKFAGQSLKITKAIGAGATTTAVGSSTIETITAFLKSRYSPEMKLLNLTAVQADPTLQSKGFFATISTTSKFFPALMKVAHELKIEVDSIDLSGNNLTDLSTISTLSTTFPTLKNLSLSNNAISRLKVFETWRHKLNLLRELIITGNPILNQANPQEIKAELMKSFPRLIVVNGEVLRNEAMLNSILAFPYPNPQQMFFQDEEIQGMSTNFVTSFFGLWDSNRRDLIQLYQAESQFSLSVDMSHPHMLEVANVDFGYYLPFSRNLTKISASKSRMSKVCIGPDQIFKAFTQLPKSKHELVTKPDMFSMETYRFPQVNGIIINLHGTFGETAPPENLEAFNNAAHRNRFQNNRNKKPPLSNKSFDRSFVVIPGPNGSMILASDSLVIRSPSGCDSWSKQSKLPTPPPAQPQQQQQKLPQTPPPNGPSALPMVTQLPPDVKAMLNAAQQEILIKVSLETNLNLQYGLMLCQQSNWDYQQCIINFKNSVGSLPRDAYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3U1</accession>
    <name>G3B3U1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_121315</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3U1"/>
    <dbReference type="STRING" id="590646.G3B3U1"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_22_0_1"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022758">
        <property type="entry name" value="Helicase_Sgs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11408">
        <property type="entry name" value="Helicase_Sgs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="364"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="567"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="983"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1031" mass="118105" checksum="5E2CB8A081A53610" modified="2011-11-16" version="1">MYQKYINYLEIKCSLLSQRYSIFESSSISLDEKNRFIREEFTPKFAKIESSLDSIKNLLPRFALKDLSQISDVGEVEITSSVQVPGTLSEIPEVQVQNSTANVSEDDFSELEVTQVNLTKPSRLPNDGLISLSSEPDVFVAAPSSPPRTPLRSEDDVEDEFGQHEMDGLMTPTHEIDDADTDLSGFVVDDVDVEDTEDISEFGSDAESIAETQFHIDQDELNDLRLSQDVADNFGINYEEMDNDLELDNDFITTQLNDERELNYEVIEISDDEEGVSDLGGHTTFVKPEKTSQKARKPAYDEFDEFDDEFADDVVEMGITTSIDIIREQQNRYPGCEPYIKEIYSVLNKKFKLQNFRSNQFEAIISLLQGRDVFVLMPTGGGKSLCYQLPSLIKIGARNQGVTIVISPLISLMQDQVQHLKNKNIKAGMINSKIEYSEKKQIIDLFKTAQLDLVYLSPEMVNSSAQIQRIIKQLYDTKQLNKVIVDEAHCISSWGHDFRPDYKAMSIFRQNYPDIPIMALTATANDKVRLDILHLLNMKSPKVFKQSFNRINLYYEIRMKKAGFVEDIRDTILAKYKNQTGIIYCHSKQSCEQISMKLNQFGIESAFYHAGMSTEDRFEVQDSWQQERLRVICATIAFGMGIDKPNVRFVIHSFLPRNLEGYYQETGRAGRDGLHSDCIMYYSYKDARNLQLMIQKDEEYNQATKDNHLSKLRQVIQYCENNHDCRRRQVLQYFNENFDPKDCQKQCDSCNNNGSEISRDFTDVSRSIIRLVQSIQNEKITLLYCQDIFKGSNNSKIVSKGHHQLEYHGMGSKLTKLEIERIFFHLICEGCLEEYSVIKGGFASNYVRVGLQASQVLSGTKSIVIKFSNIIPETKATPVSGFVSAKTNKPIKLPQNNLSSFVNASNRMHIDRCFHELNLIRNQRKIELNFQNANSILSDDSLKKLAIMLPTSKQEFKKYVNNNDQLNYFIYFKSKLMELSRERKEKSGQKVGRNLKTNGTHSGGSQRHRGSKYFKRPGAAKKKRSQKTMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3X0</accession>
    <name>G3B3X0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113906</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686196.1">
        <property type="nucleotide sequence ID" value="XM_006686133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3X0"/>
    <dbReference type="GeneID" id="18247175"/>
    <dbReference type="KEGG" id="cten:18247175"/>
    <dbReference type="HOGENOM" id="CLU_660554_0_0_1"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="416" mass="48475" checksum="1837C6F12D5CF213" modified="2011-11-16" version="1">MNQDMEKTPHTDSSEEPATPVSMETPLPPHYEREHFFDHCEEGPRMRGHKDRRFKDRKRMLAGFKFMALLIIGLTAFGSYNYGKNQGLMEAYQMRGMPPREHFRGEGFHPEGFHPEGFHPEGFHPEGFHPEGFHPEGFPPRHPEGSHQDGFHPVGSPPVGHMDWEHKNWKPHHGEGHSDDMHLKGAINFESFRKARDAVKKTVEAAEAKGIDYRKTEEYWNAKKALAEVVDKHFEELGSKLEDNNAYWEAKTAARETRMAVKEARKAVTEARNAADAAHIPFWKSDQFWEAKKALYQIQDELNVDNKIFRSLSLHQEEIPPLEEMGKHFRNMHHDEHDEHDEHDEHNEHDVKEEGFFSSYLWFLMPKPDKPFHHKGGEMIPKKGCSEGKDKFTKIKFHKESKGKHHEELSDTKKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B423</accession>
    <name>G3B423_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_104645</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B423"/>
    <dbReference type="GeneID" id="18245741"/>
    <dbReference type="KEGG" id="cten:18245741"/>
    <dbReference type="eggNOG" id="ENOG502QQKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006922_0_0_1"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33416">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33416:SF20">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1241" mass="141059" checksum="4180490C61531784" modified="2011-11-16" version="1">MSNSNPHYLPDPHSDTNRAINHSASQQSPKNNLPVSQQQKRQHSLSNYMPNNSNKRMPNPTPSATPSQQPSSQDHSFSSTAAVTSQHQSQQPQSSSRPQNRNSFRRSVLQQQYPLGGAVAGINSTKTPTPSSYEVPSSPNVNQSLSVQNISDSPDSNPPQDHQQGTSQPQGPVKDSSQLSDPEGNTSTFSAAPTASNHSATTATKASQPREMTEEEQQLATKLKDTYKNIVNYEEIVQKNCLEISLKISQFTNNSHSMTYGNSPIVGIAQGLAQSSPALINNVKSSELSNELWNVYHNNISLLDNYTDFLVTALKPTSNDQRDHFKTGKNIVDLYKIPRRMWVYGVVAFLEVLKNIINIFQEHEICSSFIGHCFTIISNLTDPVLDMEGWWSEKLGDLSRMAIALYSSRFIDWKVSAEHWYFIAMRTLYGHGKIYYHMCTVQQDNLDALVNIGKSVICRDPFVPTQQYLRLVVENICTQRNILSILELPIIDFIKIHKVLLSINTNQLNSNKSGSNSNNGENNIENLHETQLQYGIDLVSRYGITFGSDSNGYNFFTRQLYTPNGVTNTSDPRTPYYLQQQLSPSSQNGINSLEKLNFWLNKGPLFAIANINHIVGLGDSKNPFAKIFLLPEALKERKDKKDRKRKSKSSIAEDFANANSSSVNSSTISASEISEAEWVYYLKDINKSVLELSVRILKHYLVGPIEASYGHVIIWLYFLIAVGEATEKHPESKPLFFWLFKYIFPWDLLINYLNTLLIMVKSNDMLLKRCRDHILNTPNYIQYFNDHENLAEVWKCWGTLWFDFISAKTDYCEFDNAGISDYNIFDLPVSGISASLRAGNNLENLKSKESPNFDDNNIAENNDRIIRIILLSRYLADHYEFGLVRSHDGFKYWGDIVPLFSEFVPQEVEFVTSNFLYGDNRFISHSFFDKFSDENAYTFNERISIDSLDDEWFERNDSLSMFDSQGPGESRNAELGDAMEDFGEDLEQERRNKELEDQVNKLYNQQHEVLKSNLNDDEFYNTNFMINPENLSIISENNLGTNNVASSLVEGNLGDRMDTSLTYITLDTNIWLKHCGRIFKCIRNGVFKILIPLIVFQELRSLRKSSEVTIADAATRSVIIIRELHSAQELLPLRFDGTIASDINETTEFENNSNWRANIDETIMKAVNEQNEISRKVLRGLNSTIAGKLLDTKLSKSFCYCILITDDRNMRLRAKTIGVTSFQSKWLFSQLEGNFYSKCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4B5</accession>
    <name>G3B4B5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="13">PE methyltransferase</shortName>
            <shortName evidence="13 14">PEAMT</shortName>
            <shortName evidence="13">PEMT</shortName>
            <ecNumber evidence="13 14">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_93448</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 14">Endoplasmic reticulum membrane</location>
            <topology evidence="13 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13 14"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4B5"/>
    <dbReference type="STRING" id="590646.G3B4B5"/>
    <dbReference type="GeneID" id="18250292"/>
    <dbReference type="KEGG" id="cten:18250292"/>
    <dbReference type="eggNOG" id="ENOG502QRGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005987_0_1_1"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 13 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 13 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="872" mass="101642" checksum="104F6F8005CE29B6" modified="2011-11-16" version="1">MSNTISGARGITFSGETFTVPQTHDMVKTLFDPTIRKSLFEKVIVFGLIFNFSFIFWFSNSIRIDYFIAGYLFWRFAYDFGIGYLLYNQSKYNKMVNWAKKLQVFEVGSNSWLARLIRYEISSQMGTKYSINDYPIEFNTWLVFRKVVDLILMNDFVFFMGLFVVCSIDKDYQFINFDQQPAWLVYFRLIVGPILILFNYWVKNDAHNVIKDYAWYWGDFFFRQINNEDLIFDGVFEMVPHPMYSIGYIGYYGFALIAKSYTVLILACIGHFLQMIFLHFIENPHIDKIYGPSVVEVDLGKLIKLKDLKYFRHLKPLIGFYNFNIQRGSDIVNLILIVTYSGLLPFLFYVLKSTDTTSVFSICFDTTKIFFFLTLTLKVAESVFINSLLFCQSYYKSFTKYYLVNDIPIEDSLNNFAVIYNSFISLSYSSLVGLNIYFFMTGLNRVDLFFESYYYLRIFVGVLLILTQIFINQSIVDSIGYFGWFYGDFFIPKNPNSLSLTKAGVYRYLNNPEQIFGVCSLMGIFLIIPNFENLVLCGLWIGNNFARINFIEKFHMIKLYGKEEVLKDSGVTKTLKSLIPASRRSSTSSSANKKIFHERKNSNSIILNASETIDQIIKEFKKSNKKLTKQNIFDISQNLYFENSDYKLTLTNLKFNDDNDNNLIKYIEVGENINVEFHCPANHSPKDWIGLYKIVQTGYNRYKTLISSNNRWEWVPENKDSGVLSFAKDKLFWDEGIFEFRYHLDGKHDVAYISEPFEIKVPSIQVPSDTEGIYTFAKELKERVIDRVILMSDINENIIAKTESGYNGSILETYNRLSNLVSLATQIQVSNKIFLHPEELSILHLSSKIVHMKKVLDDLSFEKSIPAEKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4H7</accession>
    <name>G3B4H7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUC173-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_97869</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4H7"/>
    <dbReference type="STRING" id="590646.G3B4H7"/>
    <dbReference type="GeneID" id="18250719"/>
    <dbReference type="KEGG" id="cten:18250719"/>
    <dbReference type="eggNOG" id="KOG1248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003753_1_0_1"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="350"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1085"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1040"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1151"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1163"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1196" mass="133006" checksum="F3CA6D3EB6E2591D" modified="2011-11-16" version="1">MATNNPDGGHSDELFEMENKLSKIRSQVNSKLDNQKHLAVILSAVEENLQDQKTEKTPVAYFVSFCSLLDQSISNDFIVDQGLATASSYFLDIVLPFTAKPLLVSKFGDILAKLAVPITSSDAEAPLVRSTIGALESLLLAQDYQRWTSNDSISPQRAMAGLLELTMDHRPKVRRRAQEAVSSILKNPPTSPNPMHPASTLCGKIALERLASILESNKSKHNKEVNAQIIHCLQLISSVTSSGSWPAKQIMPLCDVLLEVSKTNDQFIVSSAFSAFEGLFQSMNNVVNLERFSQVLDVIFDLKPAVNDLHLAASWLAVVAKASECFAALDASVYITKFSNIFHQVAAFLSSESKDIYSSASHCLTAITAAIPDEYLLQPSKQNGISPEVYESMDDLISGLADTIEKDLLTIKHQHAFKEILEFINESILKLRSRANPDLLGIVETIGDWRTTESEDFSHNKEAEDVLASAISVMGPEVVLGVLPLNLNSTTSPGRAWLLPLLRDNVRFANLGFYISEILPLVEFFQEKISNLNKDSVNVKIFQTIIDQIWSLLPPFCDLPKDLTVAFTDSFASQLTEVLYSNVESRANICNALRTLAESYITYSDEELSKDLLAQEELSIEQATVGLEYLASKASNVLSVLFNIFSSTSPDSRGFILETIDIYLMIVPKDELENTFNKVCGLLKNAMDEESTETQTKKKNTPSLSITMMDLIVAMAKYVPSSSHTALFSIFSSTISSKNPLMQKRSYRILTKLGEVSEGQNSIKQFANDIANVIISTIDDTQSSARATRLGAVNDLIEILPNDFLHFIPAVLQEIIMCTKDANERTRSLSYQVLIRMGEKMEQGGVISNSKVPGFDPATPDSEANLTEFFTMVSGGLAAQSPHMVSATITAVSCLVFEFKDKLPTDVLVELCSTVELFLTHNSREIAKSTIGFVKVEVLSLPEELVKANLGELLSKLMRWSHQHTGHFKVKVKHIVERLIRKFGYDEVEQAIPEEDRKLVANIKKTRTRAKRKQKEDGTGASEKQGKKFVSAYEEALYDSDVSDNDDSEDEVDTQRNKKSSQFIMESRDSPLDLLDRQAFAKISSSKPRKEVKRNYSERAETKNGKFVFNEKATSDPLSNKGSGIDAYLDAVKQGPIRGQKNRMKFKKDNADDDWSDDDEPPQETHHRPSKNDKFKGNARISKPKPKQKFKAKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4T8</accession>
    <name>G3B4T8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFG box profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_113891</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686584.1">
        <property type="nucleotide sequence ID" value="XM_006686521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4T8"/>
    <dbReference type="STRING" id="590646.G3B4T8"/>
    <dbReference type="GeneID" id="18247168"/>
    <dbReference type="KEGG" id="cten:18247168"/>
    <dbReference type="eggNOG" id="KOG1073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019221_2_1_1"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="3">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="4">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29214" checksum="D01E7DD33BF233B8" modified="2011-11-16" version="1">MSQYIGKTISLISNKQLRYVGVLDNISAEDATIALKSVRSFGTEGRFSQAGQPNLEVAPGNDIYDYVVFRGNDVKDLSVLDAPLDQITPEPTPTPTPQPGAVPHAPVQTAAPVAQPHQASPQRVQPTPTTTEPPTKASPAQPVPAAVPEPSNAQPKTKSDKKLEYTEDFDFETANSKFVKEIESEKEKPTYQKSSFFDSLSGSTDEKSGMRWNEEKQLNYDTFGESSVDNGRGRGRGRGGYRGRGRGRGRGRGNGRGRGNYEKTPEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B561</accession>
    <name>G3B561_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="15 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_114466</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="17">Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="15 18"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B561"/>
    <dbReference type="STRING" id="590646.G3B561"/>
    <dbReference type="GeneID" id="18247433"/>
    <dbReference type="KEGG" id="cten:18247433"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_3_1_1"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV63146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="466" mass="54072" checksum="7B2AF62D03548880" modified="2011-11-16" version="1">MSTEASPLLQTPTNDSETKPGYIPKDKIEWEFGGPLGAAGMIFGFPLLMWYMWISAQFYNGALAWPQDGQSWGEFGYDLWTYFVKFGLPSWKTTATFLGFVVVQGIFYLTLPGFWTKGQPLAHKNNEQLPYFCNALSSLYVTLALLLVFHVTGIYDLSTLIEDIGEFTTISIFTGVILSFLLYFYVLFVSKDYLDLTGNFIYDVFLGTTLNPRIGKYLDLKMFFEIRIPWYILFFLSLSLVLKQIKDYGSPSVQAVFLLTAHWLYANACSKGEELVVPTWDMAYEKFGFMLLFWNMAGVPFTYYHCILYLAYHDPSEYAWPWWVMVVLFVVLFASYYLFDTGNRQKNSFKKHIAGDKKIRKTFPYLPYSDLVDPKFIKCENGGVLLTDGWYVYARKAHYTADYIMCLTWALVCGFGSPLPWFHPIFFLIVLVHRAARDSRKCAKKYGKDWDRYLEACPYLFIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5A9</accession>
    <name>G3B5A9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_93944</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5A9"/>
    <dbReference type="STRING" id="590646.G3B5A9"/>
    <dbReference type="GeneID" id="18250340"/>
    <dbReference type="KEGG" id="cten:18250340"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003662_1_0_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="709"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1097" mass="120479" checksum="786C5F962F966CD9" modified="2011-11-16" version="1">MAPHALAQLSGANSPSASTAASISDVAPSAIASAIKWNPFDTSVDPGLIKGSVYTSAVTVVNQAIFGLSNRIFTSDSVDDSYAFDGHLHAWINGFHRVNPSGQTPFLHKFETRSGAGRAVLGFINESTGPSRDPVSVLTDAAGLAYMVPALSGRQKPTPVAFAVAAAAFNQSTDALVPCYEKPLAAARLLNYPVFTPTDVYNGLEHQHLAILAKYLSKETGRPSVFLFDGVDGAKGFTKHEGLLSVDEVHAVYHQLESGHVTSTGSPESVVSEAFDRLSAATGLKYAPFEYVGHARPETVFVVHGSGECTKIGNVIERLAATTKVGVVKVRVPLPFSFNDFIATVPKSTAKLVVLSSSSGAAVSLKGDISMALFVNGVYNRFDIDEYTYSPDFVWTPITTTKVLHEFVADLDPDSALTTDVERFSQPLTANSSPNGSFLVWGSDNGEFASSAAKLAFALSLDDSKTVSFRSKFDNARAGGLFQAQIVSAGSTAAINEVDAADVALVDDPAVLKEYDVLATLRPEGTLLLGNRKKYDEEELVKKLPADFKRSLASNKSQLVVIDFSSLDELTELKDSTKGFSNEFLIQYAFWSVALPELNGFIVNKLLQANGGGFELLGAVLDSFINTVKEKGLLKSIKVEESWVDLETDEEEVLQLPFFPAETSFTINPRNDSEIPEETVQSGYVDLAKKLAFREAYDTKKDLRPDLPVKNFVVKVQENIRLTPDEYSRNIFHIEFDVSGTGLTYDIGEALGIHGRNHPEDVEEFIEFYGLEGDSLIEITNKDDSSVLEIRSVRQSLAETLDFLGKPPKRFYESLAEFATDDKEKEALTKLASSEGAVDLKKRQEVDFCTYWDILEEFQSCRPPFAELVKIIAPLKRREYSIASSQRIHPNAVHLLIVVVDWTDSKGRKRWGHCSKYLSDLSIGDELVVSVKPSVMKLPPLSKQPIVMSGLGTGLAPFKAFIEEKIWQQQQGMEIGDIFLFMGSRHKKEEYLYGELWEAYKDAGILTHIGAAFSRDQPEKIYIQDKIRDKIEDLTNAMVDKNGSFYLCGPTWPVPDITACLEDVMKNAAAKKGEEIKDLTKLIEDLKEEGRYVLEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5C3</accession>
    <name>G3B5C3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114502</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5C3"/>
    <dbReference type="STRING" id="590646.G3B5C3"/>
    <dbReference type="eggNOG" id="ENOG502S9TU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372014_0_0_1"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="1">
        <location>
            <begin position="135"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="195" mass="22887" checksum="CA484069E151608F" modified="2011-11-16" version="1">MEQITEKVNDVIAVIPPKLEQLQQYFKHHFVQDVESYIDEFKSLDSDQVLESFKQLKVNSVTVTISIVGLTTLFVLGRLLFGGSSATSEEKPKKKKKKTSKAKKANKQIQDLLDNFETTWVPQINDYFNDYKTMKPEDAQYKYKYFQEMLLKELFKLDEVDTLGNPVIRENRKKVIQFIQDHQKRLDAFKKEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5J5</accession>
    <name>G3B5J5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_106444</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5J5"/>
    <dbReference type="STRING" id="590646.G3B5J5"/>
    <dbReference type="GeneID" id="18245886"/>
    <dbReference type="KEGG" id="cten:18245886"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065016_0_0_1"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="386" mass="42024" checksum="0984464F1E485523" modified="2011-11-16" version="1">MSKQYISTNCVSGAHNSDIFDVAVVNKYTITVGSDGYARFWDNKLDEIHNPKDHCVSHQIDPTGIHHINTYENTLNLNGDHVKVVLVGFGCFSGYTKISFFVGDDVSGLKEIKVPKELQKSSWTPIFYKDPESKQDYLVVTQMDGGIVLYKLDITGSKDEIFIELTKQTELKTIEGSFPISVDVSQVVDGNIAVGYTNGDVVLYTLETLKVINSFHSTDLQTSGNSKTSNAVPRVVTFSPGGSVLAVARDNQNSGSITLYDVKYGENVGTLTKPSHSTSATVGGFAHDGWIMGLSFDDEGELLGSCGFDKCVRIWNLDDKERVATLNLSASDFEDTDQTEMDSSIASGISFISKGTRGVSGGDNNHGICVVSFDRGVRWYRQAGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5K8</accession>
    <name>G3B5K8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_107108</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687046.1">
        <property type="nucleotide sequence ID" value="XM_006686983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5K8"/>
    <dbReference type="STRING" id="590646.G3B5K8"/>
    <dbReference type="GeneID" id="18245934"/>
    <dbReference type="KEGG" id="cten:18245934"/>
    <dbReference type="eggNOG" id="KOG4533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048479_1_1_1"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29217" checksum="8DAA781DD12BA62E" modified="2011-11-16" version="1">MNYNHLVLVPCHGIWKGGPSAGDDPNEWFLAPFQLDGKDHLCFKEHLFQGFDIMKNDPSALLIISGGKTKAEIDLSEAQSYYNILKSVYDSKDLGAVELEEFARDSFENVIFSICRFYEITSTYPKKITVTGFEFKRSRFVKNHFQQALGFPLENVKYIGNAPTPPKESEGNYFMELNQSEHEFAVKFFEVDLYGRKGSLQKKKLSRNPFNVSHDYKSSNSVLREALELMEQPNKTDLEVRTALLTVAPWKANYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5P3</accession>
    <name>G3B5P3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_106477</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5P3"/>
    <dbReference type="STRING" id="590646.G3B5P3"/>
    <dbReference type="GeneID" id="18245891"/>
    <dbReference type="KEGG" id="cten:18245891"/>
    <dbReference type="eggNOG" id="KOG1281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_8_0_1"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="686"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="803" mass="89088" checksum="09B994311DD9ED14" modified="2011-11-16" version="1">MKFSHSLQFNAVPEWSSKYIAYTTLKKLIYSLQRDQLHQAHALEDEESSHLISNEHRTFKDPGVVFLAALDAELKKIDEFYQRQEKFVLSSLEILVKDIEDFEQDLDSGRKNSGEFGEFSLTHSRSQEEDIPKARNFSGMSQTDPGDHSEVTEDENLVNSKTVENYLKSPKSPGLWGHTDNLPPQLLLLTETRILLRKRVIALYTTMSELKSFIELNKTGFKKALKKFDKSLNTNLKDEYLDNLSRKTYVFRDETANKLDGTLDSVIKLYQIICNHGDIETAKSELSIHLREHVVWERNTVWRDMIGLERKNYATKTGTEKNSKADKTVIDTFNLSLKNPIVIRSILITVVTLILLNVSIFEDPQQEKCFALMVCASLLWATETIPLFVTSLLIPLLIIIFEVLKNDDGTAMNAVDSSKYILGTMWNSVILLLLGGFTLAAALSKYQIAKSISTEILSRAGTNPSVVLITIMGIALFTSMWVSNVAAPVLCFSLIQPLLRTLPKDSTFKNALILGIALASNIGGMASPIASPQNIIAIEAMDPQPSWGQWFVIALPVCVVALVLVWVFLLITFKCTSKNTKLVSIRTIDEKFTLIQWYIISVSVSTIVLWCVASKLQGIFGEMGIISLLPIVLFFGPGLLTTEDFNNYPWNIVILAMGGTALGKAVSSSGLLKTIAIGIQHEVEDFSLFGIAITFGLLILIMATFVSHTVAALITVPLVSEIGANLPDPHPRLLIMITALLCSSAMGLPTSGFPNVTAICMTDEFGNPYLTVGTFITRGIPSSIITYFVVITIGFATMKLINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5U3</accession>
    <name>G3B5U3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_135134</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5U3"/>
    <dbReference type="STRING" id="590646.G3B5U3"/>
    <dbReference type="GeneID" id="18249848"/>
    <dbReference type="KEGG" id="cten:18249848"/>
    <dbReference type="eggNOG" id="KOG2636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027160_1_1_1"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031590">
        <property type="entry name" value="PRP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16958">
        <property type="entry name" value="PRP9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="412"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="509" mass="58777" checksum="CCFB8C806F9E6DDC" modified="2011-11-16" version="1">MSQFIELQRSRLEELDIIRQATSKRFRKNPSLIPTNIRERDDILSGNKERPFKETMLQKHELKLFQDKYNSNTKALNSLDKDLVETSLNKINDPEFKFEYFDSLLNGLQEKEDSSLFNEDLKSLYSIYSSSPLQEVSTSKKGKLRAKRKYVLSENASRLLNIDALFTPEEQFGKFLDLKSFHGTYLSLTKSDCTYIEYLRMFNKVPYEGVSNDPTYKKYIHNLCVYLSGFLKRIDPLEDVSKLLHEIESSFKDNSDGDVGKTDENGEVYCKACDRTFSKETVYKGHLDGKKHKKNAKKLVTEDANETEISANKYKEFIIKRLSETLKVSIEDTINNIERQEGMTERERMIELSENKEEESDYTTADSNYSGSSGNESSDDEDNELFKDLPLGADGTPIPFWLYKLQGLHHSYECEICGNMSYKGRISFEKHFSSVKHQRGLKFLGVDTSKMSLFANITKIDEAQQLWVTLKRESKLQDGIADDAIEVEDNEGNVMSERDYIQLKKQGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Y4</accession>
    <name>G3B5Y4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_106665</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Y4"/>
    <dbReference type="STRING" id="590646.G3B5Y4"/>
    <dbReference type="eggNOG" id="ENOG502RXNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047849_0_1_1"/>
    <dbReference type="OrthoDB" id="5380163at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="295" mass="33702" checksum="F9D77848D1062E9F" modified="2011-11-16" version="1">MVKKLLIKASNSYSDNFQIVPINTLIPVRIQSEIGDFELSINIKNFDGSKPHAANSLYNLGDQYYLDKTPIDPEKFHKNEVETSQIPNLTFEVNFRPKFPVNGKEFSFGNDFTTPIKDYVPTTLLSAGLKFFNWFINSTVKGDVYCDKPFLYGPILNSCTYMSIDEDMPSKQSVLDTSSQKFPENLNSNVDNILKIPEFSLERKKFFNKLVNCENFVFVESSMYKLKFDTNFIKMADSKYSVSLPTYNNSTFDINVSKYANDKLDNFNWIIKIGGYEGVGYGKLGLVVNFSLVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B606</accession>
    <name>G3B606_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114649</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687143.1">
        <property type="nucleotide sequence ID" value="XM_006687080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B606"/>
    <dbReference type="STRING" id="590646.G3B606"/>
    <dbReference type="GeneID" id="18247523"/>
    <dbReference type="KEGG" id="cten:18247523"/>
    <dbReference type="eggNOG" id="KOG4134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060987_0_0_1"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000004">
        <property type="entry name" value="RNA polymerase I subunit Rpa43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="10">
        <location>
            <begin position="122"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="296" mass="33708" checksum="8D778391B6877B00" modified="2011-11-16" version="1">MPEQYHKNNMNGHKRRKQFIIPESNNPINKDGISECFQSFQTDMYVSLAPCHISSPINGIKAQHLDPLIMNYFPKAQGVVIAYSNIKLLDGKTEDNVPLAKISDSSPFTFSWISVDLLVWRPQLGDVLEGYIYMQTASHMGLLVHDTFNASIKKFNIPSDWKFIPSQIDEYGEDNETENSSQFKSLGHWVDENEIKIEGKLKFNVKNIHSSGRFVSIEGTLIKPGTEEENQPVFRNRRMSLSNDQFQASQASNSNNHKKFDDNDEITNNDISEEVPHYTEGSDNEEAIINESEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B627</accession>
    <name>G3B627_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_135189</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687154.1">
        <property type="nucleotide sequence ID" value="XM_006687091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B627"/>
    <dbReference type="STRING" id="590646.G3B627"/>
    <dbReference type="GeneID" id="18249853"/>
    <dbReference type="KEGG" id="cten:18249853"/>
    <dbReference type="eggNOG" id="KOG1792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050576_1_0_1"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045064">
        <property type="entry name" value="Reticulon-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10994">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10994:SF193">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="14"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="278" mass="29612" checksum="01D3E71638776690" modified="2011-11-16" version="1">MSSSIAPTSSNTSLCELLTWQNPIKTGKVFGSLILGLVVFKKVNLINIVFHLTYIALLFSAAAEYAGKLVTGEGFVTKYKPTSKAYAKTVNDTILPAIGKGASYAEDVTNKVIYSHDIETTLKAAGVSYVLYKLTSWFSVFTLLTTALVLAFTFPVVYSKNKKEIDAAVAQFSTTAKAKVGEFSKLAQDKAAPHVENLIKKSGPVGSFIKSKIPTRTAGSTVGADRSASFEAEKPTTATTTGASSFPEVPTDSIKDDSTFEDLVEEAKTAGVNAAHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6G1</accession>
    <name>G3B6G1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114777</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687479.1">
        <property type="nucleotide sequence ID" value="XM_006687416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6G1"/>
    <dbReference type="STRING" id="590646.G3B6G1"/>
    <dbReference type="GeneID" id="18247572"/>
    <dbReference type="KEGG" id="cten:18247572"/>
    <dbReference type="eggNOG" id="KOG1594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048345_1_0_1"/>
    <dbReference type="OrthoDB" id="4024111at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="302" mass="34090" checksum="6AA2EFE106A40F7B" modified="2011-11-16" version="1">MTVEEHEDKVIVSLDSDPSTSVTILKYGATVVSWKLRGKEQLWVSSAAKLDGSKPVRGGIPLVFPNFGKTKDESHATAALPQHGFARNSTWEFLGQTTQSPLTVQFALSPDEANSDIYKLWGDGTNDFTLIYSIGLSDTLHTQIEVENTGKQAFDFHWLFHTYFKVEDIEDIIVNNLTEEKCYDQLLQSWYTEKAPMVNFNEEFDRIYKDIPEEKVLQIIDKGYVLQNLRRSGLPDAVVWNPWIKKSEGMADFEPKSGYLNMLCVECGNVTDFVKLEPGKAWTGSQTFQVGGEILVQSNIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6R2</accession>
    <name>G3B6R2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_106733</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6R2"/>
    <dbReference type="STRING" id="590646.G3B6R2"/>
    <dbReference type="eggNOG" id="KOG2628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_0_2_1"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="221" mass="25985" checksum="B36CACE8A96346BE" modified="2011-11-16" version="1">MSYDPSKVNLTVVCAKSVALGAVISTCLSFMFEPGFFHLSSYVLSICIFHLLEFISTSVWNTSQVDDDSFILTDYDLLLVNVCSLVEHYMLRWLEIRPVIQLQYLGVFLMGLGQFFRTASMYTAKTSFNHYIQRVKSDDHVLVTHGVYAVSRHPSYFGFFWWFVGLRVYMNNWVVLGYSGYKIWRFFKARIEFEEKFLVQFFGDDYREYRRRVGTKIPFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6W4</accession>
    <name>G3B6W4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Globin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114341</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6W4"/>
    <dbReference type="STRING" id="590646.G3B6W4"/>
    <dbReference type="GeneID" id="18247383"/>
    <dbReference type="KEGG" id="cten:18247383"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035143_2_0_1"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
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        <property type="entry name" value="ABL201WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="2">
        <location>
            <begin position="167"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="389" mass="43336" checksum="B2DA3CADCCF37527" modified="2011-11-16" version="1">MNRRRSSNSTASSASSIITVTSSNSTQSSMNTFDHQSVLSTRKASRLSNLNPMKPRSVSGKSDMGPIASHQNGPNGHIASHNSYYNLTPMSTNSLTEINNYHLTKMDTNDSIDSNFSLQSQFKIELNMSRKEIELIRFTWHKMLLEEPVVQTESSLPIPGGFRFGDQSNSLQQQASQHQQSDLKPANNIASSLFCRQLYGNLLNMNPTLEKLFPSIKHQAVAFAGVMSFTISQMENLAGLNEYLESLGKRHSRILGIEPSMFELMGEAMIQTFHERFGTKFNQELEILWIKLYMYLANSLLQFGIDPILKLNTGDNSHDHHGSSGLFRLNEISQPAVRTPSAPSSAKEDLFSVADGKRSSVSTGSANTSFDLKKKDKGMNKKKRDCVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B729</accession>
    <name>G3B729_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_106956</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B729"/>
    <dbReference type="STRING" id="590646.G3B729"/>
    <dbReference type="GeneID" id="18245925"/>
    <dbReference type="KEGG" id="cten:18245925"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_15_1_1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12447">
        <property type="entry name" value="RRM1_gar2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="104"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="231" mass="25547" checksum="9F21140593BC0F92" modified="2011-11-16" version="1" fragment="single">EPATLFVGRLSWNIDDDWLKREFEPSGGVISARVIMERATGKSRGYGYVDFESKADAEKALQDFQGKEIDGRPINLDLSTSKPQTPAKNDRAKKFGDVVSAPSDTLFIGNLSFNATRDKLFEAFGQYGEVISCRIPTHPDTQQPKGFGYVQYGSIEEAKAALEALNGEYIEGRPCRLDYSTPRDPASSQKPRFGGDRQGGFGGNRFGDRSATNSPRPQKTAEFRGTKRTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B760</accession>
    <name>G3B760_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114422</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686901.1">
        <property type="nucleotide sequence ID" value="XM_006686838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B760"/>
    <dbReference type="STRING" id="590646.G3B760"/>
    <dbReference type="GeneID" id="18247419"/>
    <dbReference type="KEGG" id="cten:18247419"/>
    <dbReference type="eggNOG" id="ENOG502S1N8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068116_2_0_1"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="208" mass="23548" checksum="5B0E0BA34761363B" modified="2011-11-16" version="1">MSKTALIEVDRFVFSAFDADVSQRFIQSSPYTEKEHFLDLETLSYEHRVLALALQSFQVTSEDYATGGYFDSFNIEDVVREARAIAARLGKPLQPFSVYIVAFRSKLFDNVRVSAEKRATLGDIDKDSHLEANISGGLLKYFFGVPDQDGNNLATCWWVDKDYAQRGGGGKAHRNGVKVVRSWYQKWQIEEYVLNVAESLISFGSYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7C9</accession>
    <name>G3B7C9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115707</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7C9"/>
    <dbReference type="STRING" id="590646.G3B7C9"/>
    <dbReference type="eggNOG" id="KOG2897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1864867_0_0_1"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="137" mass="15177" checksum="405BBF41F196FA1B" modified="2011-11-16" version="1">MFTPVTDLTPENPMFEDLNRLPKLGIRQEIIEEVVEEDTNDAAITLNTEAPLGLYLPNGNKKLCLITGTEVKYFDPSLGVPYSDVETFKFLKSMEQGTIPWYTLDGTYNDTGSTEIYLGSRDGSSRSARGVPEGFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7M6</accession>
    <name>G3B7M6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115109</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7M6"/>
    <dbReference type="STRING" id="590646.G3B7M6"/>
    <dbReference type="GeneID" id="18247722"/>
    <dbReference type="KEGG" id="cten:18247722"/>
    <dbReference type="eggNOG" id="KOG4102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098333_3_0_1"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="117" mass="12565" checksum="A6841D7F485E13E4" modified="2011-11-16" version="1">MSAPPNQGSTAQTGSRTQIETHPQSQQEQAPVPILHLRKHTKKPKVSWADDTVDNEHMNKKKTKICCIFHPADPNHSCESSSESESDASDDDGVAGGGAAGGPNAYEVQPKYPRASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7U4</accession>
    <name>G3B7U4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA mismatch repair protein msh3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_126075</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7U4"/>
    <dbReference type="STRING" id="590646.G3B7U4"/>
    <dbReference type="GeneID" id="18249146"/>
    <dbReference type="KEGG" id="cten:18249146"/>
    <dbReference type="eggNOG" id="KOG0218">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_3_1_1"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="17">
        <location>
            <begin position="783"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV62324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="923" mass="106125" checksum="49E0420E3A6C569F" modified="2011-11-16" version="1">MKHIQISKFFKPAKRKLEARDTHVDVNHTEPSNKKPTPKEKETCKASSSKIQPAAKVSKLTPLEKQILDLKDGHSDKLLAIQVGYKYKFYGEDARIVSKIINIMLIPHTDSRFNYCSIPDNRLHVHLKKILTFGYRVGVIKQIESTISKTMESSKGIFERKLTGVYTSATYMNEEIEDGRKLAIDDDNGQYVCCVNHMDNSTGFVVIKPLTGEIIVDSFEDNDLHHELETRLVYFKPSECIILCNDEVTTMTLTKLVNSINNLCKVETRDINKDVLQELESFFGNDDLDKNNLFDYYKVNFNSLILNCIHGLVQYLEPFKLNTIFTVPSNIQKFKNDDYMILSSNVLRTLEIFENSTDNTTRGSLIWLLNHTRTKMGERMLFKWVSRPLTSREKIQDRVDALDDLSKEFNHFIDSLTSLLTNDIDLEKGLIKLHYSLSTAKITRSEVYKMLSKFNKILKLVKSFEKEIEKLNGSLKSRELKSIFNELLDLAENFDIESIHLNFISSTYGNSDSKEQKYQYFNLDYHNWEDISNQNDQISNINQEIEEETKAVSKILRKPIRLVKILNQENLIEVRNTQANSVPVDWVRINATKSITRFRSPNLQRLNDLLIYNRELLDKVCDRVFLKFLGTINENYFKFSKIIHNLSKFDCLLSLVVTKASGVKPIVLEENSIVDIKEFRNPIINTLTNYITNDAHITSTENRISLITGPNMGGKSSYIKSIGILVIMHQIGCYLPCESAKLSIFKKIFIRMGSFDNIIKGQSTFMIEMIEILNILQNFDSSSLILLDEVGRGTGTFDGYVIAYSIIQHFCGHAESPVVLFITHFHKLTELANEHKVVGNFYMDFIKKPESDEIQFLYKLVPGILDNSFGLNVAKLAGIPEEVIERAKVKSIEMKNDMDIRAITDVLRMIKEKNLEKAFETIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9G0</accession>
    <name>G3B9G0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_108239</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9G0"/>
    <dbReference type="STRING" id="590646.G3B9G0"/>
    <dbReference type="GeneID" id="18246015"/>
    <dbReference type="KEGG" id="cten:18246015"/>
    <dbReference type="eggNOG" id="ENOG502QPT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_10_2_1"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="7">
        <location>
            <begin position="208"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="357" mass="39741" checksum="F447A037F96C14B2" modified="2011-11-16" version="1">MKPSALGIHVLGAGSIGGLVAHELQIANPESNIMILCRTLEAAKRYNSQLTVNRVHKDGNMISSTTRIRSGTAATVLDYNPPLKIENLIVSTKAYQTPAALAPYTHLLSNTSNVLFIHNGMGVIDKCIDRFWSRRRESPRIFKAVVTHGAYKTSPNIINHVGLGKMTISRIPNGVPFENEDIPQMIQNILQNKPLNATYTDYDTFVLKEIEKLAVNACVNPLTAILDCKNGDLLKGKKVFQMMMRVIWELVATIRVEYKPLFIAMPEASTVIDPKRLLDAVIEVIENTASNSSSMREDVRNLSPTEIDYINGYISKLGKKHSISTPTNNMLVSMIKTKYSIDRTLENNASEFVINQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9H8</accession>
    <name>G3B9H8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_115338</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688059.1">
        <property type="nucleotide sequence ID" value="XM_006687996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9H8"/>
    <dbReference type="STRING" id="590646.G3B9H8"/>
    <dbReference type="GeneID" id="18247826"/>
    <dbReference type="KEGG" id="cten:18247826"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="117"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="222"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="332" mass="36079" checksum="6E419F91F960BC1A" modified="2011-11-16" version="1">MSDVEELAHAIAGAGGGALSMVVTYPLVTLSTLAQTSKKSKQKHEENDPHTITVKPSAIEAGRQIIAEKGVLGLYAGLESALYGITLTNFIYYYFYELTSNVFLRANALTTRKGKGLSTLQSIVTGAIAGAITCVASNPFWVANTRTMTAKKETDKDGKNRSTSTFGTLLSIIETDGVGTLFAGVFPALVLVVNPIIQYTIFEQVKNLVVSRNGKNSFTSGKAFFIGAFGKLIATSLTYPYITLKARMHIKKKQVGGEQAKPVEDVKLSMVQEIKKILREEGVEGLYGGLSVKLLQSISTAAFLFYFKEELLTGSIKLVEILRLLRMKKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9M4</accession>
    <name>G3B9M4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115379</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688873.1">
        <property type="nucleotide sequence ID" value="XM_006688810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9M4"/>
    <dbReference type="STRING" id="590646.G3B9M4"/>
    <dbReference type="GeneID" id="18247841"/>
    <dbReference type="KEGG" id="cten:18247841"/>
    <dbReference type="eggNOG" id="KOG3901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076665_0_0_1"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="150" mass="17449" checksum="4703A98869BC2571" modified="2011-11-16" version="1">MSVNTSRKRRKQRLFSKDIEQLLYALGDGPYSMESTINALEDSLVEYLSDLSTATQIYARSKNRNRIKVDDLPFTLRNDPYKLSRLQYIVNQSQKIENAKKIFDEDDKKLADYGDEDDDEDDDDEQLSKPAEDEEPSGKKFKKSKKKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9N9</accession>
    <name>G3B9N9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_94812</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9N9"/>
    <dbReference type="STRING" id="590646.G3B9N9"/>
    <dbReference type="GeneID" id="18250440"/>
    <dbReference type="KEGG" id="cten:18250440"/>
    <dbReference type="eggNOG" id="KOG2653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_1"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="199"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="509" mass="55846" checksum="BFA8462799EAE670" modified="2011-11-16" version="1">MDRLQLVNSHVSGNNSRTNIVASGDIGLIGLAVMGQNLILNAADHGFTVVAYNRTVSKVDEFLDNEAKGKSIIGAHSIEELCANLKRPRRIILLVKAGKPVDAFIEQLLPHLEKGDIIIDGGNSHFPDSNRRYTELNEKGILFVGSGVSGGEEGARYGPSLMPGGHKDAWPHIKEIFQSIAAKSDGEPCCDWVGDAGAGHYVKMVHNGIEYGDMQLICEAYDLMKRVGGFTNKEMGDVLAKWNKGVLDSFLIEITRDILYFNDPTDNTPLLEKILDTAGQKGTGKWTAINALDLGMPVTLIGEAVFSRCLSALKDERITASKKLTGPSPITITDKQQFVDDLEQALYASKIISYAQGFMLIREAAREYGWKLNNPAIALMWRGGCIIRSVFLGEITSAFRENPDLENLLFHPFFNKAITKAQSGWRATIGKAVTSGVPVPAFTTALSFYDGYRSETLPANLLQAQRDYFGAHTFKVLPGKENDFLKKDEWIHVNWTGRGGNISASTYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9U1</accession>
    <name>G3B9U1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase I-specific transcription initiation factor RRN11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_135901</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9U1"/>
    <dbReference type="STRING" id="590646.G3B9U1"/>
    <dbReference type="GeneID" id="18249916"/>
    <dbReference type="KEGG" id="cten:18249916"/>
    <dbReference type="eggNOG" id="ENOG502R1IK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025508_0_0_1"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="61855" checksum="06BBE6C1AB553955" modified="2011-11-16" version="1">MFEDPASSLVWLPGSQLKLDKAILRYQQHKVYQALLQNKTLSGSIKKKIKESHYKQILLKKIKESMENPTRPEEAFEIWNQSDHMNVYRRSTNTEPLKFDEEFLDNMLTNAQRHREEENGDSGNDDDDSGSELIKEHLFEEYFNKLTRPADFSGISRKPKLEFLLTTEGYEVLPLPSEETKTGFYRYHIANLNFFLHSSILNKSWDQAYKILCILLRFPGIDIRYLWPLAIEILRGKHNENKETTSVFKYKERRFFSWLASFYILSASRPGLVENAPVFRSGSVTHVPIFIIESIWSLLDDGQVERVKTEVKSLILKAPFENEGVFSFILCLCYLMENVQLADRYAKVDTSDENDLEVNIFLNDKASIYAKISSNFEEVDKYLHKCTELKFEYPPDIVEVQTNIILSKIKEADEANTGNQSDEDNISEEEIPDPYDTMNDTNNHNEDEVSHDTIIEQANEGTEISKRVSLEDEIPDSYIDDEEEEIPDQYDDEDEIADQYVDVVPVTETRNTINNERNDDSDSSIDFDFDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9U2</accession>
    <name>G3B9U2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_115423</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9U2"/>
    <dbReference type="STRING" id="590646.G3B9U2"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497911_0_0_1"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="335"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="458"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV62727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="584" mass="67373" checksum="2CB487DED8A84780" modified="2011-11-16" version="1">MVELSNQLKYFLGYLTLSAGATAFAIWGALTTSNTYLGFSYQMTDGIYLGIVLNFLFCIFILFSTSAQHLIFGELRLLEREHVIERLPFLVVNLLLNLTTKDNNLTLNVLLLMITLFSKVMHSILMDRLEFKQMKVVNELNNSSFYTIADVLQFYAKNSFLYWNVVFLTIDFSIAKFLVYDVFQGINSVPCLLFGLQFAVQGLECLTFFLKCMLDLYELVRYPIYTPDEMDMDDLDNDLDTEPLEKVWENKGLFSKSIDIASSSFKTISYLCFIYLLTTSAGFSVPISMLQGTYLCMRDTYKEVKQLLAFIESSKRLDSQLTDAKSEDLENDSKCIICFDEMLSAVTDEGSQRSNMNSRLKPKKLNCGHVLHMGCLKDWLERSDNCPLCRRRVFEEPEMPGTPQVQQQEQPQQPQQPQQPQQLETRQERQLLDDQDLRPLPRHNEMRRRFAHFEEALAQHRQRRQGPQSRSASTNETRPTPTTDFPGALPRAYSQPERNDSTEGNIQTLHQIVLPRNSVLPPNWTLLPLRRANQDVVDYHVQFSRNVLAKLRVHEKTAERAMNIIDPGLVTSSEDTQELTRRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9V8</accession>
    <name>G3B9V8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115436</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="219" mass="24843" checksum="6B80352496D07E62" modified="2011-11-16" version="1">MNSKALKALGRKAVVQFATEVKNGLRQPLSKEEVTRSIDNKHDNKDPEEAKPKKSKNAGVVKQAKVVMEVKGSGEVGRSRGYGFIEFRDHKVALMGLRWLNAHEVGIEEILEGLNDEERKLAELTGLNKRKLIVEFAVENSQVVKRRRDKVYQARTHHGKDEGEENGSRKRRSYDDRKADKKQKRNDKAPTPQAKPKSGLSDDVKQIIGAKRRKRKGKN</sequence>
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        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
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    </evidence>
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    </evidence>
    <sequence length="128" mass="14118" checksum="2038C8CCF4DB2464" modified="2011-11-16" version="1">MNHETKEPRRPSISVSQPDSGPIPFPSHKPNRSRSSSQVITPAVGKTKEEVKRQYSYSVSSVGSDMDDGLGTNNPYANRNRKLSEVDLENQLILTAGGSREDVCCFFIKLFVLMILVIGSGVLIFYAL</sequence>
</entry>
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        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
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                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
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        <source>
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        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
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                <person name="Lucas S."/>
                <person name="Lapidus A."/>
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                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="364"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1016" mass="114361" checksum="4E652C4E5BE1B9B7" modified="2011-11-16" version="1">MSNPPNSSNSQDQLLQDASTLLMFANVAAKQQQEIRQNTPSPPVVPQLGSHHPVGSGSFTSPQAPLPPQPATQSAVSQPPYVKHPVFDPVRQIYINHTPYNHLPPHHRTALPPAEVHQVQFPSVAGQTTGAAAVPSPPTTASTTNNINGTSQLGPPSSSVPVSTHVSAHSSVSEPGSKEASLHVPAHRRTSSVPSTTVSLTHALSPGPASVVLARGSSNGTNNNSIIAAAALAQAADNPLPLLKHEEAVRREIKHEVIKSPVVADKAGVKTEKKPEVPEQEPVVPKSEPVVHKQEHVVHKQEHVVHKQEHVVHKQEHVVPGKKPEIPEVVAPTPHNDDKPLVSKDYVAPPLSEYKVEPDSGVIGCICGISDDDGFTIQCDICYRWQHCLCMDYSTNEEVPEDEYKCYFCDKEKWGKFDPEQCRHNTVTRLQQDNDNQDVSTSKPGNKRKVSTSGRVGDKKKSRLNPNQERPKDRRKQLRDDFSNPTSAVDEIPDFIPNEDNELLDDGYTAESYQSTYYKLRSNDYLNHQSQKHFEDLGDRFYDSFQQLSEDEKEKLNIEVVTLKNFKAIPRMYVKLPNHETHMQAHNKPIKIPNVYIQVKQYSDSQKQKFNGISKLSLFVQAQREGSKEAFEDLIPKGTPILEYFGVLNEFSQYRDNKPNQYNVWGTTKPKVLKTSLSFIDKGKQIKDFDVVLDSRFVGNETRFIRKACPPAANCEVKAFYIPEAKSFRFLVVTSKDIKLDQETSEEELRLPWEWDEAHPIRKMYGDESKNIEGLKFDQLSDKEKTLLITTIDNLLYFTECGCSTTTNTPSYLPNCAVFKVRKAISYLLRATRKVSGIINVNMYKPKDELIIPKEPKTYVPWEQRLHNREEFIQTKLFVPTPTKVIKFDDDEEVSRDTIKDIIIKNQLVKLTDNSVEVIDGKYHNDKVLDLVPISTGISAKVEKTVEAEVQVKPEIKKSLSELKLKLTDNNLTKINKVLNLNLEKRVTPPPIPAEPSEKPMVKKKLSFADYKKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB93</accession>
    <name>G3BB93_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114989</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB93"/>
    <dbReference type="STRING" id="590646.G3BB93"/>
    <dbReference type="GeneID" id="18247659"/>
    <dbReference type="KEGG" id="cten:18247659"/>
    <dbReference type="eggNOG" id="KOG2878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056986_0_0_1"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="292" mass="33566" checksum="0140352D065A8E34" modified="2011-11-16" version="1">MVPYPPGPEPFYRYVSDIVSNWQLSPTKSPIIIGVSGPQGSGKSFAVDQAVAFLYAQFPHVKVAQMSMDDVYLTHAQQQLLTQKSIEQMDNNRLVQGRGLPGTHDLELLGDVLHKIRIRDEVAIPRYDKSAFNGEGDRAPRETWTVYTKQQAVDVLLFEGWFNGYLAIPDEEMSKRYNALPADSASKTNTLQHMLQVNDFLKKYGSVWYRFDYFINFETEDINNVYKWRLQQEHDLIAKRGSGMTDAQVASFISRYMAMYEVYYEDLCRSGSLVEDTDSFNIKINLERRVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBG4</accession>
    <name>G3BBG4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="18">C-1-tetrahydrofolate synthase mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_99240</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:23701"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:23702"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:22813"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:22814"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:20222"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:20223"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBG4"/>
    <dbReference type="STRING" id="590646.G3BBG4"/>
    <dbReference type="GeneID" id="18250840"/>
    <dbReference type="KEGG" id="cten:18250840"/>
    <dbReference type="eggNOG" id="KOG4230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_2_0_1"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001741">
        <property type="entry name" value="Formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001859">
        <property type="entry name" value="Formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF26">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="16">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="17">
        <location>
            <begin position="183"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV62184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="990" mass="106830" checksum="49F6122D9BF92A87" modified="2011-11-16" version="1">MLRTRTRASHAALRLARPTAARAFHPSPVVLDASIISGLKLAKSIRSNIANKVLAYNHDKFGTTNATFDTIRFKPNLTIIQVGSRPDSSAYVNSKLKAAKSSNINSRLLKFDEHITEEQLLEEVQNINNDPKVHGLLIQLPLPPHINETLVTNAVSTDKDVDGFGRFNVGELAKRGGRPLFKPCTPSGVIELIRTTGVDMRGKNAVVLGRSDIVGNPVAAMLKNEDCTVTICHRHTKDLPQLLGRADIVVAAIGMPEYVKGEWLKEDAIVVDVGINYKADAAAKNGRKLVGDVDFSSAVQKVQYLTPVPGGVGPMTVAMLCSNVFDAAMLQEQKNHQHAFKPLHLALQDPVPSDIAISRAQQPKKITKIAQELGLLENELEPYGHYKAKVDPKMVISRLDDFAEGSIQEKGNYVLVAGITPTPLGEGKSTTTMGLTQALGAHLGYNSIANVRQPSMGPTFGVKGGAAGGGYSQVIPMDEFNMHLTGDIHAISAAQNLLCAAVDTRMFHEYTSKSIKGFYKRLVPVKKGSRTFTPSMIARLQKLGIHKTNPDELTDVEITKFAKLDIDPESISIKRVVDCNDRFVREITIGEGKNEASKFPPRKSGMDITVASELMAILALSTSLKDMRQRIGKIVVGTQRETGEVITCEDIGAAGALTALLKDAIKPNLMQTLEGTPVFVHAGPFANISIGASSVIADRLALKLTSPSNPTNNGEKGFVVTEAGFDFTMGGERFFNIKCRASGYKPDAVVLVATSRALKLHGGAPDVKPGQSLPAEYLTENLEFLQKGCANLAKQIQNVKQYNVPVVVAINQFETDTAAELELIKVEAKKAGADFAAVTNHWAKGGEGALELAKAVTEAVEIPKSTEQSFLYDVNSSVEDKILTIAQKMYGAANIELSPLARKQVETYTQQGYDKLPICIAKTQYSLSHDPSLKGVPTGFTIPIREVRCSAGAGYLYALAAEITTIPGLPTHAGFMNVEVNEDGQIDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBN6</accession>
    <name>G3BBN6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_99249</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688364.1">
        <property type="nucleotide sequence ID" value="XM_006688301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBN6"/>
    <dbReference type="STRING" id="590646.G3BBN6"/>
    <dbReference type="GeneID" id="18250841"/>
    <dbReference type="KEGG" id="cten:18250841"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_0_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF13">
        <property type="entry name" value="SUBTILASE-TYPE PROTEINASE RRT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442894" description="Peptidase S8/S53 domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="128"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="405" mass="43400" checksum="378148A01C9A6739" modified="2011-11-16" version="1">MKWALYIFSLFCTVNCSSYFITLRDNESFDDFYANDMKYPEPLRVRDQIRNIFTIGKFKGFVGDFSKTALERLSRCPYVSEITPDITFNALEIQVQPYAPRHLARISSKKKLKKNLVFVYDDVFSGQGVNAYIVDSGIKIEHPQFEGRAYFGRDFTGLGSGDTNGHGTHVAGLVGSQTYGVAKNVNLIEVRALGDGGSGSLSTIIAALEFAVNHRRRSGKPGVANLSLGSVRNSVLNRAIDAAVEDDLVVVAAAGNTNTNACKSSPGSAIGAITVGSIDDSSDAIAGFSNWGECVDIFAPGAAIKSVDYQDLKVPKSLSGTSMSAPIVSGIVANLLSAGVPPSDVKTTLLKMATNGKVKRTSLLLKGRTPNKIAHMGLNLPDAWEDKGEENSDADTDYESGSDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCB1</accession>
    <name>G3BCB1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_116225</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCB1"/>
    <dbReference type="STRING" id="590646.G3BCB1"/>
    <dbReference type="GeneID" id="18248205"/>
    <dbReference type="KEGG" id="cten:18248205"/>
    <dbReference type="eggNOG" id="KOG1636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="128"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="259" mass="28804" checksum="268C788FC42EA5D6" modified="2011-11-16" version="1">MLEGKFDEASLLKKIVDSIKDSVKMCNINCTEHGLTVQAVDDSRVLLVSLLVGQSAFTEYRCDRDITLGIELDSFGKILRCGNNEDYLTLLAEDKPDSVMAIFEDKKKERVSEYSLKLMDIDSEFLNIDDMDYDAVITMPSTEFGKTVKDLKNLSESLNIVVTKDSVKLSSEGESGSGSVVLKPYSDIDHPEETISINLDNPVDLTFGLKYLGDIIKATSLSSSITIKLADKTPALFEYKLDAGGYLRFYLAPKFDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCC7</accession>
    <name>G3BCC7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_137273</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCC7"/>
    <dbReference type="STRING" id="590646.G3BCC7"/>
    <dbReference type="GeneID" id="18250049"/>
    <dbReference type="KEGG" id="cten:18250049"/>
    <dbReference type="eggNOG" id="KOG0011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040364_0_0_1"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14378">
        <property type="entry name" value="UBA1_Rhp23p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="315"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="356" mass="38608" checksum="8EF01ED942BD946F" modified="2011-11-16" version="1">MQITFKDFKKQKLTIDVEVDDTVLKTKETVASQKSCDVSQLKFVYSGKVLADDQSLGSYKIKEGDSIIYMISKAKKPVVPVAEPPTAATTGDSSESAASEPVAPTPSATTVAPVSEEAGSAFAQGSEREATIQNIMEMGYDRDQVEQALRAAFNNPHRAVEYLLTGIPESLQQPVEPPTAVEEDVDATPVAAETTQDDKDHDHDTSDRNVNLFEAAAAANNASAGEGDASDPVGELDDAAQLQLLREAIQTNPELIHELLEQISRSNPHIAQLIQQDPEGFINQFFGAGAEEGFEIDDEAMEEGEDAGVRIEISEEDQSAINRLCELGFDRNLVIQVYMACDKNEEVAADILFRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCM4</accession>
    <name>G3BCM4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_116258</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCM4"/>
    <dbReference type="STRING" id="590646.G3BCM4"/>
    <dbReference type="GeneID" id="90981856"/>
    <dbReference type="KEGG" id="cten:90981856"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="162" mass="17462" checksum="C032F70D897A7A5F" modified="2011-11-16" version="1">MSKVFFDISANGAKLGRVTFKLYNDVVPKTTENFRALCTGEKGFGYANSAFHRVIPQFMLQGGDFTRGNGTGGKSIYGEKFADENFAKKHEKPGLLSMANAGPNTNGSQFFITTVACPWLDGKHVVFGEVVDGYDVVKQVESYGSSTGATRAKIVIEASGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCT6</accession>
    <name>G3BCT6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116934</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCT6"/>
    <dbReference type="STRING" id="590646.G3BCT6"/>
    <dbReference type="GeneID" id="18248511"/>
    <dbReference type="KEGG" id="cten:18248511"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_1_2_1"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="167"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="274" mass="28898" checksum="182340E7B3BD11F7" modified="2011-11-16" version="1">MKDYTIAVLGCGVMGTAVTSAILSTSFDEYPSKIICCNSSEKSSNALKAKLTHPIVEYSFGAESNKNAVEQADVIVLGCKPYMYKDVYEQVKGGLSGDQLLISLLAGITIEELQVFSPYVAKVMTNTPAQFGCGMATIAFSSEAEPKYEQLVMKLISPVGKAIKIPEKNMDAATALVGSAPAFCLLMMEALIDGGVRMGIPYDTARQCAAKVMEGTGKMVDQTGDHPAVLKSKVCTPGGTTIGGLLKLEDAGVRGAIARAIEEAANISKSFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCY6</accession>
    <name>G3BCY6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116290</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCY6"/>
    <dbReference type="eggNOG" id="ENOG502S73A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177980_0_0_1"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020301">
        <property type="entry name" value="Mrx7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10906">
        <property type="entry name" value="Mrx7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="68" mass="8325" checksum="D952CEB6F3C61BC4" modified="2011-11-16" version="1">MTPIERFLYEALIRSPGFNRFVQSVYNRVNKITIHRTVTDYRPTMGHKINAFRIIWINEVKDLFRFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD47</accession>
    <name>G3BD47_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_137381</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD47"/>
    <dbReference type="STRING" id="590646.G3BD47"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="449" mass="48973" checksum="E9CB906B5CC6678A" modified="2011-11-16" version="1">MSAPALNYKVADISLAAFGRKDIELSENEMPGLMHIRKKYGQDQPLKGARIAGCLHMTIQTAVLIETLTALGAEVTWTSCNIFSTQDHAAAAIAASGVPVFAWKGETEEEYLWCLDQQLFAFKDNKKLNLILDDGGDLTSLVHKKYPEMLEGCFGLSEETTTGVHHLYKMLKEGDLKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKTAVVAGFGDVGKGCAMALRGMGAKVIVTEIDPINALQAAVSGYEVLPMEEVASVGQIFVTTTGCRDIITGEHFSKMPNDAIVCNIGHFDIEIDVAWLKANAESVVNIKPQVDRFLLKNGRHVILLAEGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFNSKNLEFRSKYPEFAKAGDFDVGVHLLPKILDETVARLHLDHLGVRLSALSKVQAEYLDIAVEGPFKADIYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD70</accession>
    <name>G3BD70_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_127317</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689469.1">
        <property type="nucleotide sequence ID" value="XM_006689406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD70"/>
    <dbReference type="GeneID" id="18249230"/>
    <dbReference type="KEGG" id="cten:18249230"/>
    <dbReference type="eggNOG" id="ENOG502S6Z8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151392_1_1_1"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442842" description="DUF1748-domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8158" checksum="67A49A62B9EFD078" modified="2011-11-16" version="1">MVVGRIFHYTVDLVLVSAFLAGVRRNSGLTINFDSTQNKDLQYYGGKYLDMGESILDYTVAYCSSSAYFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD72</accession>
    <name>G3BD72_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116316</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD72"/>
    <dbReference type="HOGENOM" id="CLU_2704576_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="73" mass="8013" checksum="CF0FF191D6847A43" modified="2011-11-16" version="1">MDPIPTPVTPKDARPPKTVAAGKGTRAMDHESKRVEGNQTASEDHCHQRMRLPGADTHIRERLGMAPTSRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDA3</accession>
    <name>G3BDA3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_127379</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDA3"/>
    <dbReference type="HOGENOM" id="CLU_949943_0_0_1"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="293" mass="33294" checksum="986F861B9D4CAEFA" modified="2011-11-16" version="1">MAQNLVEKHYVNPSEFGDINRVVRLYEQFRFGKELIEEREMVEFMVGFERLGDIFYKYYGPFSGVRRSKPNYHQDDDIGVMDYDSDREAYSYAYSDTESEFELPRPRPARYSYSSQAQTRSNLVGPSESTETVGSVIRRKFSSVSHGSLLRHHTSSSDSKSSVIKHKLDISKDIGRSRSSFTSGLHEDTESVIGPSTIRKPRHSFGDYTLDVSGSATGTEPSEPIQNPPPFQFKLSPPIPDSSTRSRSPSPGRVLDLEFHRSRSPKRSRSPRRKIKLSLSSSSDDDDIDNDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDB9</accession>
    <name>G3BDB9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_111529</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690136.1">
        <property type="nucleotide sequence ID" value="XM_006690073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDB9"/>
    <dbReference type="STRING" id="590646.G3BDB9"/>
    <dbReference type="GeneID" id="18246289"/>
    <dbReference type="KEGG" id="cten:18246289"/>
    <dbReference type="eggNOG" id="KOG0621">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023808_0_1_1"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="337" mass="38844" checksum="ED75DC8D6C07B0C6" modified="2011-11-16" version="1">MIRRQLIHINKFAYGHAPTRLLTTTPIRWRPRERVRKAKEIPEDEVTKYYNSRSKPSGAKQFYYQDEPSSDPNSRYSVFSRPPNENGLITVHDGIYDILKEPTLVIERKVEMMNLFLGFEQANRYKIMNAMGEQIGFMQEKDLGIFKMLGRQFFRLHRPFDIEVFNNYGDLLMVIKRPFSFINSHIKAYLPGVNSHGEMELESIGESVQSWHLWRRRYNLFKLDDDVTDEYNQFGAIDAPFLSFDFPVSNADGDVIASVDRNWVGLGRELFTDTGVYIIRMDPASFDGMGGLYPSVAGPLTLDQRAVLLGNAVSIDFDYFSRHSRGGGGLLSFNNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDF9</accession>
    <name>G3BDF9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_110083</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDF9"/>
    <dbReference type="eggNOG" id="ENOG502SBGD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194195_0_0_1"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="75" mass="8525" checksum="18D1658EDA736B14" modified="2011-11-16" version="1">MLMASKGHFFTQIPHPIHKFSEMKAILEVGVTSIHNFPVFTTGHPFRHSCLHFFGLHLSEEIIAISVFLSLMFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDG9</accession>
    <name>G3BDG9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_132107</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDG9"/>
    <dbReference type="STRING" id="590646.G3BDG9"/>
    <dbReference type="eggNOG" id="KOG2110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025895_5_2_1"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46616" checksum="B402DDC807CECC8A" modified="2011-11-16" version="1">MNNIRFNQDNSCMAVASDTESRIFNSEPFGEIYTNDSPVFLLKVLFSTSLTIIVPKEKDNRLLKIFNLKQNLKICELIFPSSIVEIKINKKRLIVVLKIGQIYIYDLSYVKLIKIIEIEPLGSQPFVGDLSNDDHSLLVIPLKYVSTVMAGKSKNNGIFTDPEPLVKFNNFAEYKDPKGWVLVYDTINLKSVLIMKCHSSSIRKIVISDMIIATASSKGTIIRLFQLNFKQSEDIKLTRILNLRRGHNSAHIHCLKFNTDCTILACGSENTIHFFSLKYNEDIIDGHNYGTSTLKTYEAGDGDEHETDYNISQSSLLDAESSKSSEDLNENLANLLISKPIPNEIEENDKDVDNSIKNLPYKDYFNNLVLSPPRRSFNIIRLKDHKPGFTYHYVKQFAEIIGQSSDHDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDV1</accession>
    <name>G3BDV1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136869</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDV1"/>
    <dbReference type="STRING" id="590646.G3BDV1"/>
    <dbReference type="eggNOG" id="KOG3009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056966_0_0_1"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30898" checksum="C347FC9C0093854F" modified="2011-11-16" version="1">MQIDTSGLRVEVDNRTASYTSVHSSDGELIIACSDMTIVEEDLTDHALKHIEAFKPSTVVLDCNLSLKTINNVLAHVQISSGRIIIEPTSLVKSRKIGSLNHPVDLITPTVNEMNAIYESIDQNGRFNDDWFEVIDTLKLDDIQRFILKGKLLELYNEGIIQKCFRILPFARNILLKLGKHGVLTLGQTKESIFMAARKSQIQTANFYIDYYPVPPENENLEIVNMTGAGDSMLGYLISHYRTLDKEKLMRNCQLASGLSISHAEAINPHLKNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE07</accession>
    <name>G3BE07_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_95879</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689641.1">
        <property type="nucleotide sequence ID" value="XM_006689578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE07"/>
    <dbReference type="STRING" id="590646.G3BE07"/>
    <dbReference type="GeneID" id="18250555"/>
    <dbReference type="KEGG" id="cten:18250555"/>
    <dbReference type="eggNOG" id="ENOG502SWM7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319848_0_0_1"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="880" mass="100951" checksum="419DA516024A16AA" modified="2011-11-16" version="1">MSIVNGRSSSISSAGDKGPFMEDYSAYSVEELFQKFSIKDIQGVNQRYKQDALTAKHQLQNLVSEKYRDLISISDGIDEKCQRLELSLSNFAFKPANFVKFNSDSYSKLSYSMISEEHQQLKTAQKLTVLNDMIYDVLLGFDLKLQKRKFHQSPVVHTSKLIYYSKVYFTLESNFKNEIKSNSLLNSCFHSMKQNFNDFLKEQISCFNKSSNSFIQDSDKFEANQSFDINNIFSKTSLNLMDENEEFELDESVGESNDNPVDYVGELTETYDSNTLPIINYLVSYIILNTEGSSVSRSSVLFEFLQFRFDYLSSILTSMHVDSTNYDRVNFLNIFVFIENTFGYAANYFENQDFKNGLVKQLTKVTRNWSLGFDQYHNSKTSQRFNIDPITVKLPPSSLKDLKDVKRKFVDLIVSFFKELPVDKTVEVKASIHNLVFFKNLLISVKRIDIQCSELGFKSQITRLIAEDDENILVKILSMIISNVEESYKNHLSLISDKKDISLYGILTRGLSRTLPQSSTKEMSLFTTEFVDLISSNLTQYSDLITEASRNPTFSFRGPEEDVTKSIEGWFENNTKFLLLLETKEEPKFKFDLVELTSYLAKPLDETGVEVQWGKFSRKRMMDEFSGLTASLEKMFWTNIDEFICRISTLASENIEGKNIANIYAITKCLIMLKQNILLSTDDKVTVNERVDKINAGIEQCSNYIVETIPTLVDESSISFFDQFEAVFESILNTEESAIENFPSTPSLKLSALMFHLSTQFMNPNSSSYEKDYQNGILFIDNNNNIFANKKNEFINNILIPKAYEVILGKDIKLSKALAHLIYSNIVYLACFTSNTPNVPLDEIKSIADFEINDIDFKEISKSILEFYTASKNSYYPLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE29</accession>
    <name>G3BE29_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_95891</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689658.1">
        <property type="nucleotide sequence ID" value="XM_006689595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE29"/>
    <dbReference type="STRING" id="590646.G3BE29"/>
    <dbReference type="GeneID" id="18250556"/>
    <dbReference type="KEGG" id="cten:18250556"/>
    <dbReference type="eggNOG" id="KOG4835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101423_0_0_1"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="151" mass="17010" checksum="2D39D513C6C78EAF" modified="2011-11-16" version="1">MDDQVIKIQKFLDSLDGSIDDLHTKLQPIITKSLDEVVSNVDSPIEKIEIYNSYSYVLISIVVAYLRSKGVDTAGHPVMKELDRVKSYMKRYKDLVSSQNTSQQKNLDETKEYLQQTLGNKSVTGNTITQSMSGPAISSNSFKNTHKKFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE86</accession>
    <name>G3BE86_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116537</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689700.1">
        <property type="nucleotide sequence ID" value="XM_006689637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE86"/>
    <dbReference type="STRING" id="590646.G3BE86"/>
    <dbReference type="GeneID" id="18248350"/>
    <dbReference type="KEGG" id="cten:18248350"/>
    <dbReference type="eggNOG" id="KOG3368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_4_0_1"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="153" mass="17509" checksum="65902DD7C5685AEC" modified="2011-11-16" version="1">MLYSFYIFDRHCNCIYHRRFSLVDDGATNTDNESDVAKLLFGVLYSLKNISSKLGDQSTNAGGFNYLKSFSTSSFRIHFLETLSNLKFVLITDNLIDNVRSVLWELYSTYYLNNIALNPLSPVDFKGDEKITNPNFISQTDQFLRSLPVYGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEN7</accession>
    <name>G3BEN7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="14" type="ORF">CANTEDRAFT_131842</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689152.1">
        <property type="nucleotide sequence ID" value="XM_006689089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEN7"/>
    <dbReference type="STRING" id="590646.G3BEN7"/>
    <dbReference type="GeneID" id="18249564"/>
    <dbReference type="KEGG" id="cten:18249564"/>
    <dbReference type="eggNOG" id="KOG0482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="389"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV59938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="799" mass="90030" checksum="AEC94E246A7264D9" modified="2011-11-16" version="1">MSTTTSTVLPSIQLDINYTEIKKSLKEFLQSFKSSIEDVSMDTDNELIYGPKYMNLLQQVSNREVSTIYIDLNDLKAYEANNGFDGQIPSQVTSRSKLTDNILENTYRYVELFSSIIDEIMPNPTKDISATDDVLDVIIHQRQLKNQRVLQETADEVNNLRTGFNDQVGENQQPQEEAENLFPPKLTRRYFLYFKPLITQNKPMSVREIKGEHIGKYITVRGIVTRVSDVKPSVIVNAYTCDKCGYEVFQEVNSKVFTPLSDCNSAVCKNDNVKGQLFMSTRASKFSSFQEVKIQESTNQVPVGHIPRSLTIHVNGDLVRCLNPGDVADISGIFLPSPYTGFKALRAGLLTETYLEAQHVYQHKKQYESLEITPAIEAKIQDLFQQGGIYNRLAKSIAPEIYGHLDVKKILLLLLCGGVSKEIGDGLKIRGDINVCLMGDPGVAKSQLLKAIGKIAPRSIYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPHENINLPAALLSRFDIMFLMLDQPSRESDEKLAAHVAYVHMHNKQPDIDFEPLDPATIRQYISIARTYRPVVPREVGDYVVQAYINLRKESRRNEGSIKKFQHITPRTLLGILRLSQALARIRFDNIVTNEDVDEALRLIEISKASLFTDDQKLREDDSATTKIYQIVRSIAMGDGSQFSKTLKVDELRQRIIAKGYTIEQFMDCIYEYQSINVWQLIDDEDKIMFIDDGDDVEPEDMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEP9</accession>
    <name>G3BEP9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyprenal reductase</fullName>
            <ecNumber evidence="5">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_115976</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="5"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEP9"/>
    <dbReference type="STRING" id="590646.G3BEP9"/>
    <dbReference type="eggNOG" id="KOG1640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044409_2_1_1"/>
    <dbReference type="OrthoDB" id="541710at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="206"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="334" mass="40027" checksum="FF1278A126C7D09A" modified="2011-11-16" version="1">MDSIKHILVEQVNSNIMFFKLMYELLSDFTIDHWVALLASSLLMGLIIASSENVSSRIVLYGKNYANQPNNPSYIPQNIWERVFVRVHKITVPKKYFLHFYVFFALLMVINAFVEWNFNTNAFPQVNDFFASFYERFYTNYLTSEQNYKNLYVISNLLMIQSFRRLYECLFVSQFSDVSMNILHYVFGLSYYWMVASVNFGGILPYYIYGQSNNYKVELDMSDWLFIGVFLTYSMDQFQNHQHLAKLVKYTIPSFRLFEYCASPHYLDEIILYSCIMRFYLCCKDIRWIQVDFVLIWCLVVLNLSNSSSQTYKYYQDKFKEKFKIPYKLVPFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BET2</accession>
    <name>G3BET2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G10 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_96036</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BET2"/>
    <dbReference type="STRING" id="590646.G3BET2"/>
    <dbReference type="GeneID" id="18250571"/>
    <dbReference type="KEGG" id="cten:18250571"/>
    <dbReference type="eggNOG" id="KOG3404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087132_1_1_1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="143" mass="16557" checksum="5CAE58B61A7DA0A9" modified="2011-11-16" version="1">MPKVKSSKRGGKPPEGYTKIEPTISKLVQKLKDAQTQTEKHSVWKIIQINHQISRYVYTMHYNRKLIDKPLYEWLLKQKYVDANLIAKWKKQGYEKLCCLNCIRKEDNNFGSSCICRVPKQDLSDDKPVECVKCGCKGCSSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFA7</accession>
    <name>G3BFA7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116031</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFA7"/>
    <dbReference type="STRING" id="590646.G3BFA7"/>
    <dbReference type="GeneID" id="18248135"/>
    <dbReference type="KEGG" id="cten:18248135"/>
    <dbReference type="eggNOG" id="KOG0834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044487_0_0_1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="303" mass="35206" checksum="05152D606A161AAC" modified="2011-11-16" version="1">MVYYQKYYLFNEFNDSSEDFTDLEKNMENDPYSIALTSLFLASKNEDCIKKLRDIQAVANKLRDLNDDANYLELQRKILLLIEFKLLQVLKFNFNNNSLIVPSLDNLVVHFAKIKKLSYEKTFFSWLVCFDLMSTPVNLMLPPHCIALGVVIVATNLDTSELSITEEHIDVPVNKQSTSMNNANTKPNIKTTDFNCPELLVNESIIYILDYYVHQYGFSVLKEYLPAINKKLGKEQIFQFMNLKSKFNKLKLINEISCSKNLLPKDNYLRIWDYTTGMKGTARFMLGNKRRRFTKELDSSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFI0</accession>
    <name>G3BFI0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside phosphatase GDA1/CD39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_111440</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689911.1">
        <property type="nucleotide sequence ID" value="XM_006689848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFI0"/>
    <dbReference type="STRING" id="590646.G3BFI0"/>
    <dbReference type="GeneID" id="18246281"/>
    <dbReference type="KEGG" id="cten:18246281"/>
    <dbReference type="eggNOG" id="KOG1386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010246_3_2_1"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="254"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="81717" checksum="A4D33EC60B612A86" modified="2011-11-16" version="1">MKKGPIANSDNIPYDYIVIIDSGSKGSRVFVYNWLNPSHALKGSVDLNQYQSFKDFKLVKSATTQDNGTTPESDDEDQDNSDSDSDSDPDSNSGSKPQKQKQKPTKQKSYKARLPKVNSNKKWKHKVKPGISTFNLSPQKIGNHHLRPLLAVASRVVPKSQHHRTPIFLHSTAGMRLLTPTEQQKILDTVCEYFQSNSDFFLPDCASHINVIEGDVEGLYGWLAINYLVGAFDDPQNHQHGKNHTTYGLLDMGGASTQVVFQPNHSEITEHQNNLYNVSLCQLPKLKHSQPDNAVGKYLRPSPLAFSVYSDSFLGLGMSQAYTKFLGFLVANSPTKPGVFYNPPISDPCLPKGYVSNLKLGDDRYDFTGDSNFETCLNSIFPILSQSSYRSSSPHSGNCKQDNDDSKVSSCLLNDLIPAFDFDINHFYGVSGYWYAISTLMSYNQPQLSPRVEKHPTDTEYDYKVISENTKNICSKSYSELIDLNKMRPESQQLSTEELTNLCFKSSWILNFLHLGLGFPRFGIDEIKQDDKFKSLRLVDKIKGSEFSWTLGRAILYANDEYVEAFNNYTSQNSVASPSLLARAGFTYTPSPNSFHYGSEQNGVAKRPQFVKPVPNAKYNYYDYEKSSSKGKNESKWDIEPHRWYGGFMFLVLLSLIFWLLLGSKGRSRIVVRIKNDYQKAKDMVSSWTNHTYQRVSDVEIGEYQLQNLEVPTPSPPANFVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFJ7</accession>
    <name>G3BFJ7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_111178</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFJ7"/>
    <dbReference type="STRING" id="590646.G3BFJ7"/>
    <dbReference type="GeneID" id="18246253"/>
    <dbReference type="KEGG" id="cten:18246253"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="13">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="11">
        <location>
            <begin position="217"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="12">
        <location>
            <begin position="428"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>2</label>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="580" mass="63861" checksum="76C46799D6D049C0" modified="2011-11-16" version="1">MSEETISLGTYLFERLHQEPIGLRSIFGVPGDFNLTLLDKIDDVKGLSWKGNANELNAAYSADGYSRVKGGIEQNSEKGGSGFAALVTTFGVGELSALNGIAGAYAEHVGLLHIVGIPSIAAQSKQLLLHHTLGNGDFTVFRKMSSFISQTTGFLSDPATAAGEIDRCIREAYINQRPSYLAFPSNMVEVEVPRSLLDTPIDVSIPKNEESEEDEVIERTLELIKSAKNPIILIDACCARHNSTLEASKLIELTNFRFALTPMAKGSKYIDEAHPNFTGIYVGSLSYPKVKEAVESSDLVLSLGAMLSDFNTGSFSYSYSTKNVVEFHSNYIKIRSAQYPNVRMKQTLQRLLKSSELKEAVKGFKPTAVVKDPFEVPEPGQKSISQQWLWYHLGEFLQKGDVIITETGTSSFGIVQTPYPPDALGISQVLWGSIGYSVGALFGAVTAAEEFSSRRTILFVGDGSLQLTVQEISSMIRNKNKPYIFVLNNDGYTIERLIHGENAGYNDIQPWKHQELLNTFGATDFESIKVSTLDEISKLFKDKDFAKADKIRLIEIMLPKMDAPQSLIKQAELSAKTNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWC7</accession>
    <name>G3AWC7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_132762</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683768.1">
        <property type="nucleotide sequence ID" value="XM_006683705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWC7"/>
    <dbReference type="STRING" id="590646.G3AWC7"/>
    <dbReference type="GeneID" id="18249645"/>
    <dbReference type="KEGG" id="cten:18249645"/>
    <dbReference type="eggNOG" id="ENOG502RFPT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_0_1"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF68">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="316" mass="34258" checksum="C16CFDDBD37E343D" modified="2011-11-16" version="1">MTISSHTIPAGVYTPITTFFKSDSRYTLDLETQARHAQFLYNSGIKGLVVAGSIGEAGHMTRTERYALVAAIRAAVPDPAFKLIAGAPPLGCVQEAIEESHSAKEAGADFVILLVPGYFGPHLTSQEGIIEYFTQVADGSSLPVMIYNYPGTCNNITLTIESFRDLAKHPNISGVKLTHFNLDLYALLGKDKEICEANNFRPFTGLGQVLIPGLSVGLYGTIDGLSGIFPKTMLKLYSLFQEGKLKEAADLQFLVTKADQMLADLNLVGAKVALHKYYGFGDCLTGRPPLCRGVDEKAYAKYTADMDAIHAIEQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWH3</accession>
    <name>G3AWH3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_112260</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the vacuole. Induces high curvature in membranes and causes membrane tubule formation. Involved in membrane/vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWH3"/>
    <dbReference type="STRING" id="590646.G3AWH3"/>
    <dbReference type="GeneID" id="18246432"/>
    <dbReference type="KEGG" id="cten:18246432"/>
    <dbReference type="eggNOG" id="KOG1725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028431_2_1_1"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="171" mass="18595" checksum="4A68F06C746A0BE5" modified="2011-11-16" version="1">MDQITSILSQVDARTSHIGILGQFEQQSGLPRSYAVIAAIGVYFVLIFLNVGGIGQLLSNIAGFVVPGYYSLVALDTPGTDDDTKLLTYWVVFAFLNVIEFWSKAILYWIPFYWLFKTVFLLYIGIPAFGGAVSVYNSIIKPISDQVISGGGNIAHDIDDLATGVSTGVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWT4</accession>
    <name>G3AWT4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_91782</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWT4"/>
    <dbReference type="STRING" id="590646.G3AWT4"/>
    <dbReference type="GeneID" id="18250112"/>
    <dbReference type="KEGG" id="cten:18250112"/>
    <dbReference type="eggNOG" id="ENOG502SXPJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451258_0_0_1"/>
    <dbReference type="OrthoDB" id="4026687at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="605" mass="65423" checksum="B93F1391726F918D" modified="2011-11-16" version="1">MGLLDSDRPKSSYIPQPLPKSPLTSEPFNVRGTSSRFSFNLQSLDHEENRTSSPTSMASHSARLRKKPPPPLDFDDPSLPSPSANSIRDFTGGSRGPSAVKKSKQDDDHFNNIINHLENELDQVNVASTNEHIHGSNSIYGDRSVSPNSFEEMSPLNTARPMGPKPLTYASTGSFSFSGTSSTYPENDDTESEPDIAISPNPRYSLHAQYSDSSQSVGSRNNTSAPPPIIGAPYPMDSPIAPSPTSISYNDSYISSSNSTSDSPQLTAQTGSGIYSSPHKSSRTPSQTTTNTTKSVPLKPLISTPIINMTNDSFRNSSASNLNNSIPNMRNHRKSSSLSSIWSSSSSKNVNLATLKKTFDLRPGEGERSNYVLSVRKSAGTAYNETGPGKWKLPTGIMPLDKKNTYTTSNSKYMRLVGGVSQSKLKKGTGVELKHGHLAPRLLAAEVDDRDDISINFGRKASIAKAPINDSIPETAQSTPTQRSVSTFVSTPGAASFDSKISLSRTITDNSTQSKTPSTNVSIRSASVSRRSTRQSSISSSSSGSISDVCGNGFYQHRAYKYTEEFEEGDTDEKFDEDNTEELNYEVEKSQPMLVLANPDASDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWT6</accession>
    <name>G3AWT6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112326</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWT6"/>
    <dbReference type="STRING" id="590646.G3AWT6"/>
    <dbReference type="GeneID" id="18246469"/>
    <dbReference type="KEGG" id="cten:18246469"/>
    <dbReference type="eggNOG" id="KOG3167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_1_1_1"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000015">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit NHP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="9">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="155" mass="16857" checksum="02E57FCE9575E0D4" modified="2011-11-16" version="1">MGKKDKVKVDAEEAEDNYDKRMPAVLPFAKPLAPKKINKKVLKTVKKASKAKHVKRGVKEVVKALRKGEKGLVILAGDISPPDVISHIPVLCEDTSVPYVFIPSKEDLGSAGSTKRPTSCVMIVPGGGKTKKNADKVSEYKENFDEIVKEISSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWW9</accession>
    <name>G3AWW9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AB-hydrolase YheT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_129012</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWW9"/>
    <dbReference type="STRING" id="590646.G3AWW9"/>
    <dbReference type="GeneID" id="18249356"/>
    <dbReference type="KEGG" id="cten:18249356"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032487_1_0_1"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="151"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="508" mass="57977" checksum="CE3A13A82576C46E" modified="2011-11-16" version="1">MLFRSQVENYHPAKPLQYSKDSGEIHTMADIIAQTAPEMSHGYSYWTNPLLWSGHLQTAFTALNKFEDSDKVYYKREIISVEKDKYYEVDGHRLKYDTWEGKSTFAVDYVSTSEYDSNHLKYQPSSQTDELPPRTQYKNPNVEVFPDEERPLVVALHGLSGGSFESYVRALLNKVSPELDAVVVNSRGCAGHTITSPQLFCGVWTNDLRYFINEHVKRRWPHKKILLVGFSLGGAITANYVGQEKDDVYEKICGAFIMGSPWDFSDSSYVLRESLLGDRVYSPVMCQNLLKLLKKHHKGQLKYVEMVEKYSVDPSKFTLGHLRDFDDNFTCKLFGFNTSFEYYRHASPVQRLFKIRVPTVIVSSKDDPVCGVRSLPVEEATLNPYVTMVTTSVGGHLGWFDYSNNRWYAEPVARMMKALTALFINMSSSHKWVKDLRGLASSPNDNDHLKIDYIDVNLNNSRKLIANVNTIVASSEQYLLVNHSVNESLIKLQSASQALKWTDGEKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWZ1</accession>
    <name>G3AWZ1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112367</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684121.1">
        <property type="nucleotide sequence ID" value="XM_006684058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWZ1"/>
    <dbReference type="STRING" id="590646.G3AWZ1"/>
    <dbReference type="GeneID" id="18246493"/>
    <dbReference type="KEGG" id="cten:18246493"/>
    <dbReference type="HOGENOM" id="CLU_613930_0_0_1"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49757" checksum="0D4217A59D0D1DA8" modified="2011-11-16" version="1">MSQEYFINLIQSDNRNEVQIFDTNGFTLINSVNFGNSRLLKAIWVKGIESQDELIGLITTSNTFELLHISPIIGITERATIEQTNVTDICYFQDSLYACFDGGIINLTSQKISKLNKPIKQIVAGDKIYASDGSKVYEFNRGKLKQIKEFDDVKSMKYVDGLVVFTSEGAVINDQLAKAVTNIASVNDQVFLFRGNTVIVNEIEIKTAKNHFVDVIHGEDGYRFIYKTGSSVNSKNLELRSQTVDFSSSNGTHRISSSELDIDLDALMPQIHNLSSEVLIKKINKLTDTQSRAQLLELIETNDDEANIKTTISKLSKDTQLVLMTAIISRISKNPIESISLSLWFKHLVLVDSSVLGQISHTKLATASKRLAGSLQLLPELLSIKGKLNLMSTQQEFKAMRFEPEAFENHQEDESLVIVNGENDDDDSVVEALPAGDDDNDDDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX67</accession>
    <name>G3AX67_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Octanoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112438</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="5"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683957.1">
        <property type="nucleotide sequence ID" value="XM_006683894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX67"/>
    <dbReference type="STRING" id="590646.G3AX67"/>
    <dbReference type="GeneID" id="18246519"/>
    <dbReference type="KEGG" id="cten:18246519"/>
    <dbReference type="eggNOG" id="KOG0325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_0_1_1"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="9">
        <location>
            <begin position="85"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="131"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="8">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="292" mass="33327" checksum="7020D62C32782DE2" modified="2011-11-16" version="1">MFRRFNSTCSKFVPLIENYKTLRHVHFDGLTPFIEGQALQQSMVDANLSFKEIEAKIKRNKLELSQQGLEINDYEKGLIDKILEMKPHPTLLTFQFNNVYTGGKKIKRDPTIHQQIKAFEELGCEFHQLERGGDVTWHGEGHLVAYLILDLKKFKDLTVRCFVDSVLLKSLQDVLNKNYDLDSYLNKNPGVWMEPDNLKIASVGTNIQRGITSYGIGLNVKPDLKYLNTFTMCGLPGTSATSIQQMKPGADLDLKAVAYMYSKEIANNLNITTVEHMNGEEIRHQSIERNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXI5</accession>
    <name>G3AXI5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_91552</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683649.1">
        <property type="nucleotide sequence ID" value="XM_006683586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXI5"/>
    <dbReference type="STRING" id="590646.G3AXI5"/>
    <dbReference type="GeneID" id="18250087"/>
    <dbReference type="KEGG" id="cten:18250087"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="489" mass="55220" checksum="F9A8488C75C5FDFF" modified="2011-11-16" version="1">MSSLESKEVSLSDVDQKKNALATTVSKLDDETFGEIDPKKENQLLHKFDRRIMPILSLIYFLSFLDRSNIGNAKVAGLYEQLELTNSQYSLVVSIFYVTYILSEVPAVLIARRIGFRLFLCTMMFGWAIVTLCTAFVRDFWSLTLCRLLLGLLEGGVFPNMSLYISILYKRQEQGRRLSYLYVCSCMSGAFGGLIATGITKIHSNGTLDSWSYLYIIEGAISAVAVVCLYWLPDDPAHAKFLNQEELEVMAIREEQRKFYMGSDKFDKKEFVLAIKDPKLYMSVIIQFSVDLVLYGFSTFLPSILSLQLGFTSLRAQYLSIPVYFVSALGVYLSCYFSDKMNKKFPFILGVNALAFIGYVILLTNKKAAVNYFATYLIAIPLYSAVSLNITWINNNMAPHYRRATALGFNQTFGNLAGVIAGQVYRAPPHYYLGNGFSLGCVVVSSTTTILMYQYLKKQNQLKDNILNGAKDTRKVRSGCEDPEFVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY22</accession>
    <name>G3AY22_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_118376</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY22"/>
    <dbReference type="STRING" id="590646.G3AY22"/>
    <dbReference type="GeneID" id="18248635"/>
    <dbReference type="KEGG" id="cten:18248635"/>
    <dbReference type="eggNOG" id="KOG2680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_4_0_1"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="67"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV65752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="474" mass="51755" checksum="6D79AFEFA18C72CB" modified="2011-11-16" version="1">MATTISTNVESKDLNGVSLIAAHSHITGLGLDENLKPKESGQGMVGQLKARKAAGVILKMIQAGKIAGRAVLIAGPPSTGKTAIATGLAQNLGSEVPFTAIAGSEIFSLDLSKTESLTQAFRKSIGIRIKEETEIIEGEVVEIQIDRSITGGHKQGKLTIKTTDMETIYELGNKMIESLTKEKILAGDIVSIDKSSGKITKLGKSFTRARDYDAMGPDTKFVQCPEGELQKRKEVVHTVSLHEIDVINSRQQGFLALFSGDTGEIRSEVRDQINTKVAEWKEEGKADIIPGVLFIDEVHMLDIECFSFINRALEDDFAPIVIMATNRGMSTTRGTNYKSPHGLPFDLLDRSIIIHTTGYNAEEIKTILSIRAQEEEIELTGDALALLTKIGQETSLRYASNLLSVSQQIALKRRSNTVELGDIKRGYMLFLDSDRSVQYLEENKTQYIDNEGKVVIGTNGSFKKTGAADSMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY59</accession>
    <name>G3AY59_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Tricalbin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_118433</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573</strain>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684894.1">
        <property type="nucleotide sequence ID" value="XM_006684831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="18248641"/>
    <dbReference type="KEGG" id="cten:18248641"/>
    <dbReference type="eggNOG" id="KOG1012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001661_1_1_1"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF1">
        <property type="entry name" value="TRICALBIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="15">
        <location>
            <begin position="162"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="360"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="511"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="651"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="979"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1186"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="807"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1191"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1205"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1231"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1255"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV66321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1436" mass="158482" checksum="E58392C19176C78C" modified="2011-11-16" version="1">MSEKSKDVPNGAASNIEDVKKYNQKVHEAAGSANPPMEGKATKPPVPTNIPSIRENTTFSWEDVGSWANNSSQDKAKSLQTLKKIENYVLDHFYGDWYWNTSIIIGTCFFSWLVARIGLGFFSLLAVLLAANSVYRSEFRRFNRDIRDDLTRIHASTRLEEELETMEWLNSFLDKFWVIYMPELSEQVKFIANEILKDQAPGMGIEKISLDEFTLGSKAPRVNSIKSYTRKGQDHIEMDWAFSFAPNDTDDMTKNEIKKKINPKVALGVTIGKAFISKSLPILVEDMSFVGRMNIKLKLTEKFPHVKMVSVQFLEAPDIDYSLKPVGGDTFGFDIMTFIPGLSSFVKTLIHSTLGPMLYAPNSLDVDVEEIMEGQSNDSNGCVAVTVIRCKKLKTGPDTKENSINPYVRITLSGNPKIEEKTKVKKAINDPIFLESKTLLVNKLDGNFLTFNVYDFVDDKPNDTLIGSVEVPLVDLLQKEVQTGLVKNISESGKTVGQIEFDLRYFPTLEPIVLDDGSKEENNDSEIGIVKLNLISATNLELTDSPLGLLNPYAEIYVDGELAKRCRRLKGTNNPTWNESFESLITSQSDTQIEILVKDSANEGIVARLDVNLQDIIFESSRGQKWIKCPPLKQGGIVPSIEVVATWKALGITDENVVNETSFGSAIGGLRLHIREASDLKNLEAVGEVDPYVKVVVNGKLKTKTVTIAETCDPRYDAVYFLPIDNEHQHLLLSIMDAEPDGQDRALGSCAVHVNDFIKKNEKGYFLGYDGSEEIIEQPVLFNGQNKGFLTYSVSFIPTIPIVTHKQASHKKEYQRYLKRLEEAEAAKKKKEEELVKDYPDKFEFIELDEKDVPAPPRAEMPLDDLIKYRAGTLSVNVLKGRFEKPDLYLQTLFDDSAFPSGVTPRNETRSLQVSSSAESFIRDLPNSNTIFRVAKRFEVKSEKDVIAEKTFNTLSLLKQSYNKPIDVRIDEHNTVKIQLEFIPTAVKLHPLDTVLDVGYMQLDILRGENLPAVDSNGKSDPMAIVKLDGVEVYKTDKKRKTISPVWNETANFPMASRSRQVLLVEVYDWDLTHAPELLGRALLDLSTVEPHTSTPFSAKLDTKGEVFFKVTFKPEYVRPPIGSAGGFPIDLKGVAGNIVGGAAGAVGAVGGGAIGAVGGGVGLAAEGLGKGGSFIKGFGKSKRKKKLVDNNDASESASIADSSRTGNADTSRTSIPDTPTPKDSNHLSDETSSTAISTASSPTKSRSNHEHSRSQYANDLQSLRSGSHPPAPPIKNALPNVYTDGLPAPQRPLAPLERLETQSSTPDSTVDSSFASSIHGANAIAGRLLIIGASGYSSKSLEVKALLKTPSKERNLFKTRAAKLDKKTGSFQWSESAPFQCVPESQIILVIREHHTFGSNDEVDRFTIDLSSSIGKQQDLTLTGSKGTLTINLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYR1</accession>
    <name>G3AYR1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_133335</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYR1"/>
    <dbReference type="STRING" id="590646.G3AYR1"/>
    <dbReference type="eggNOG" id="ENOG502SGJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492569_0_0_1"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="329"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="553" mass="61457" checksum="6303D6757F0AB6FE" modified="2011-11-16" version="1">MNSLVQLSGKRHSVGPSSTNKSHNHMVDKVSTECVGNVSDPEEAVSAVSGLSSSTSTKANISETSAKTSTTEMSVGKDRWSFNKDAQPFFPTPSSPSTPSTSLDEPLPIVVMISNIVPTVVESDLEALLMETLSSSKIRDQEYIDPDFNILSFGNTNSFDEITALVEIFEYQEAETIMEKLQGKQWLNSTLEVAIMPPPSLSPSPYYGFGFFNQMMYFPGIAPYGVYGSPYGFSGRQAMMPPFGSVPPWRKAQPSVPMAQPPRTPGGASRRSSSSSTGSASKPTGVPQFVMNFVKKEEPIHNSDFSDQESSQFIDVNDDDGNPIKVNACRLFVGNVPFSSTWSRLRNFLVTKSQELETSTSIDILRVEIPMHSPKDHKEEFTRTMSRGFAIVTTGNRISSELIIKHFDGIEFEGRNLTVRFDKFPEFSNYILQQLYSGHNKDKALTSLAFERNSIQQKFYYGNGYQGYSNFPSRSHSFSHRSSNPQHNSSSPRFPILQPNFVPQVHPSVRYTTNLNIPRSIKPKQDAEPLDDLNEDEKARELVNSFKSLGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYX8</accession>
    <name>G3AYX8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Purine-cytosine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_92303</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684531.1">
        <property type="nucleotide sequence ID" value="XM_006684468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYX8"/>
    <dbReference type="GeneID" id="18250183"/>
    <dbReference type="KEGG" id="cten:18250183"/>
    <dbReference type="eggNOG" id="ENOG502QR29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF17">
        <property type="entry name" value="VITAMIN B6 TRANSPORTER TPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="57671" checksum="B2903B73F95AF757" modified="2011-11-16" version="1">MTDKVEECTSDYREPYVKPVNWLHKLDKLGVEVRGIERVSPEERELMKHSKKYAIARQFVDIFGLWFAACGGLTSMSSFFLPTLLFGLNLRDALISGIISLNFGCLVPAYCSIMGPKSGCRQIVSARFVFGFWGVKLVAIVCVVGLVGWSVVNCVLGGQILAASFGVSLDVGIVVAAVCALVISIFGIKVLLRFQTAFSIPITIANILFYIVVLKNAKYIEPSNELIAEQGYSSLTSRGNWLSFFTIGFSVTATWGGAGADYYIHIPENTPSWQVFTVTFLGIAVPTTLVAVVGIYCGAIAYGNPAWTDVYNTQGVGGLINVPFEPWGRFGKFVVVVLYISLICNNIMNSYSGGVDLQLIDRRMARIPRWCYAILVTAIYLILSLLGKNKFSAIISNFLPMLGYWISIYIAILLEENLIFRAPATRHLHSREFEDDRDVESYSYNWPVWDDPTRITYGLAAMGAFAVGAVGAVVGMNQVYWQGPIARQIGDYGGDIGFFLCFGFAGVAYPLLRFLELKYLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZC2</accession>
    <name>G3AZC2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_101439</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZC2"/>
    <dbReference type="STRING" id="590646.G3AZC2"/>
    <dbReference type="GeneID" id="18245468"/>
    <dbReference type="KEGG" id="cten:18245468"/>
    <dbReference type="eggNOG" id="KOG2298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_1_2_1"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="191"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV66296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="654" mass="74272" checksum="54E3299B8C4A44C6" modified="2011-11-16" version="1">MSTAQTPIPFSRDALEQVLKRRFFFAPSFEIYGGVSGLYDYGPPGCALQANVVDTWRKHFILEEDMLEVDCSMLTPHEVLKTSGHVDKFADWMCRDLKTGEIFRADHLVEEVLEARLKGDKAARGQDVSEVEEDEDKKKRKKKVKEIKNVKLDDEVVKEYETILNQIDGFSGPQLGELITKYNITNPATGGPLEQPVEFNLMFETAIGPSGQLKGYLRPETAQGQFLNFSKLLDFNNEKMPFASASIGKSFRNEISPRAGLLRVREFLMAEIEHYVDPEDKNHPRFDEIKDVKLKFLPKSVQEAGSNELKEVSVGDAVESGMVDNQTLGYFLARIYKFLLKIGVDKNRLRFRQHLSNEMAHYAADCWDAELQTSYGWIECVGCADRSAYDLSVHAARTNEKLVVRKALDAPVTVEKFEVDIEKKKFGPTFRKDAGKVQDWLLARTQCELEDLSKELKDNAKIVFKVDGIEQEVELDETFVKIGKVTRTEHIREFTPNVIEPSFGIGRIIYSIFEHQFWARPEDTDRSVLSLPPLVAPTKVLLVPLSSNAELQPMVKRVTNFLRKEQIPFKVDDSSTSIGKRYSRNDELGTPFGITIDFDSIKDDSVTLRERDSTKQVRGSFEDVIRAIKEITYNGVSWAEGTAKLTPFESQSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZZ6</accession>
    <name>G3AZZ6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dopa 4,5-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113017</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685175.1">
        <property type="nucleotide sequence ID" value="XM_006685112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZZ6"/>
    <dbReference type="STRING" id="590646.G3AZZ6"/>
    <dbReference type="GeneID" id="18246785"/>
    <dbReference type="KEGG" id="cten:18246785"/>
    <dbReference type="eggNOG" id="ENOG502S93P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090062_3_0_1"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028139">
        <property type="entry name" value="DOPA-diox_rel_Mll2280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="124" mass="14317" checksum="0B5EEE515E3AAE82" modified="2011-11-16" version="1">MTSFYGDIKSYDIHTYWHASSPAQAEFAAQLRQKVLDEFAPEVEAGDIRVYKLWDKAIGPHPTCMFEIDFSKPEVFAKIVPFYQMNHGSLSVLIHPRTGNDLLDHTQNALWLGHKLRLNTEYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B086</accession>
    <name>G3B086_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113061</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B086"/>
    <dbReference type="eggNOG" id="ENOG502S16T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034208_0_0_1"/>
    <dbReference type="OrthoDB" id="4095076at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="454" mass="53845" checksum="DE6BE3454E87B0AD" modified="2011-11-16" version="1">MLEKLPTEIQVRLLKLEPSSSLKMVNSHFYILYNDLFYERIISTFGEDIVPVLIKVLPWLRTYIKTLDSFRRESRSVISSRLSLPFYVDEENPLNTIYIKDSWRYVYSILRNKRLFAEYGDYKIDEPTNYIYNHFVEINRTYLLSYTKTMWLAPGDYNLNIGLVVKHGNGLGTTKFEIRYENDRGDIVTETFYPPTNINDILPKKQFCLLRLGEFSIPSSRTNHDSFNKSHHPKLYKVELTMEEIGLYLKSGFRIFFIDLAQPTVLFNQFDLLYYTVRETDYRYFINIPLKNFYKALNYIQNGNSDNLSYQIALKDYGTGDPFEILDSYDDKFVTDSLHNRKAGQVDSLTDLKDPKAISDKQLMRYADFYFNKAFIRRYFKFNTIYQRRQFVNRYGDFELDWKKGENQNFNSTNTYDSYSHSQSTFSLVAPDTNRACIYDLHGLKWKIPTLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0J6</accession>
    <name>G3B0J6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA damage checkpoint protein LCD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_97311</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0J6"/>
    <dbReference type="STRING" id="590646.G3B0J6"/>
    <dbReference type="GeneID" id="18250679"/>
    <dbReference type="KEGG" id="cten:18250679"/>
    <dbReference type="eggNOG" id="ENOG502QQI0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402302_0_0_1"/>
    <dbReference type="OrthoDB" id="4078000at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018622">
        <property type="entry name" value="DNA_damage_chkpnt_Lcd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09798">
        <property type="entry name" value="LCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="78854" checksum="2C834DCA6DB1E703" modified="2011-11-16" version="1">MSNDDFSDDDDFFESIKRHQLTHSSPQPTAASNTDYDISQVPGEIRSKLFRADGEIAILKSQLESVKSRGYEEIKHLKEDNEETKRSMEEQIKMLKFSVQKLEDEKKFLDNQVKSTFSKKRKLANPSEETIPVTQAQRVAPTTVPVATGQRIIRTQNDTTLLTDYIWKLSINGSDRTIMEYLGKVTLKDSLEIQGYRFQEKIPISSIILEYLISRKNLRLDKLLEELFSIINELIVHLIDTSLITSVPFMLSLLHGILGFKPSAVNENTIVISVSRIFEIIMLYKYTLSNEDRELFNYNKTPQMFLLEKFTLICSMDMLEKLMSLCNLHQEVKLGSRLFHEVRILDLVNQLIPKNDEALMNGAQINIIYNVVRILDNFYDTNDTEETSSQTVHSLLNINLVGVPIKEDFRFYGLNRCIGNNTDFQEIDKIIFSDNATVDPSSLIILPNPISERSKESRNSNYSIEYNHEFHVLDLRLQISQSIENYIINRMDTSILKEIEVVKLMIRSINLQQNGILRSPRSKFVDLRIKIICSFVRNLNYVFKTSKQLNEIINSETLNELSIVLSQIAFTSSSDLSGSSAKLYKLLRTQNYRLKILNEESEAKARELSNVNFSNKNKEYLAEVENEHANGLETLYDHETVELAREILGFCIDNEVADNLYININGAEMVDDNRFDEMDIVNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0J7</accession>
    <name>G3B0J7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribosomal RNA small subunit methyltransferase NEP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_113170</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0J7"/>
    <dbReference type="STRING" id="590646.G3B0J7"/>
    <dbReference type="GeneID" id="18246839"/>
    <dbReference type="KEGG" id="cten:18246839"/>
    <dbReference type="eggNOG" id="KOG3073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_1_1"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="282" mass="30756" checksum="2A707390442950E6" modified="2011-11-16" version="1">MTDSKKKTVESATTNGTAPSSSASLKKDTPKKDLKDKDPKSIANIPTFVPASLVPVQPAPLSSKDKSTKRMIVVLSHACLETHKVSSGGAGGDKFALLNCDDHQGLLKKMGRDIAEARPDITHQCLLTLLDSPINKAGKLQVYIQTARGVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRSVNSEEKLLKVIKNPITDHLPTKCRKVTLSFDAKVVRVQDYVSTLDDDESICVFVGAMARGKDSFADEFVDEKIGISDYPLSASVACSKFCHGSEDVWGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B186</accession>
    <name>G3B186_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">CANTEDRAFT_121075</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B186"/>
    <dbReference type="STRING" id="590646.G3B186"/>
    <dbReference type="eggNOG" id="ENOG502RXM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071875_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="324" mass="36086" checksum="0922360B76EF20ED" modified="2011-11-16" version="1">MYEYNSRSEKNSILTDRMLPRKEQNNLSVPISRVGSSARLNQLNSPGNFNSFPSTPNAYQVSSLNPIRASSRSVPPKSIQDQQFEEKFNNLEIVQIVRDFEEQLANLSRKASSFEADGLEDTISSLVDINQQIIEQIDQLGKHKQLGETIQALEDEKVGLADRSRSILKSLIEFRSELNKLPSLPTNKTEPQDSLADMDIDEVLKYGMKLSKFTKVPPSASGMVYQIHPNNFIWPAEDSLRRGMLAMSSLKGDEIIQKELGIKGNDNVPTEEMEDIETAGNEDTFKKPAPKGANHNKSSDATIAAAAPTLNLDLFDPDDEDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B195</accession>
    <name>G3B195_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF654-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_121092</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685719.1">
        <property type="nucleotide sequence ID" value="XM_006685656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B195"/>
    <dbReference type="STRING" id="590646.G3B195"/>
    <dbReference type="GeneID" id="18248823"/>
    <dbReference type="KEGG" id="cten:18248823"/>
    <dbReference type="eggNOG" id="KOG2422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008321_1_1_1"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="80925" checksum="C6C940D4AB19D475" modified="2011-11-16" version="1">MSSRQLRKLERQRLEHSLTPEATENVKEINETPVTAKTFNAFSFLEDGDSEPDSEEVAKHIQDITEPESLPKSSSKPKKNKKNNKKGKKAVIPENSDDELDRILAEAKAEDLKKYGTQEQTHESQVIVAEDGDDFEEEYNEDIEPLPEYDPNFKNFTTERLQQSLSILSIGSIKNLDPDEELKSLFGNLSLETIEDANTTTSLAVSPEVLKQFKRLARLTKGWGGKDKRSVPGTTRKLLLTRIKDDYLPTQQKPLQMEELDSSEILDLMDYKENVAEISELELKIRKEKKIGVRYFSFRKNSTVQERVANTQFYASVVISPDHDALIALLRNYPYHVETLLQVSMVLLRQGSDKSTSNALIEKCLFVFDRCFHKFFHDLLSDASNGLVRLPYESFMNRQFYLCIFRYITNLGERATYFTSLSFCKLLLSFSPAEDPLGVRYFIDYYAIMSQEYKFLTYLVESPLVTSYVKWFTPGIAFSTVLAYLHLNDTQKAEDLLKKAFLAHPYTAFQMLETIGLATSISVRETDIFVNDEIILANQTYMVRAKELWKGEDKRKFLNEQLTTLFDAHKGTLNREATKASGVRSLFSNLLGTLSTPPSSNAHKELPFNLLRFAILSGENSIMAKVPQEVWSRDDVYEFDPLPPSNDTLGYSAISGVEEGTKIIDGALDYVDQNVLASIIQNRTQNDEFEDIVRQLQEEQLQQPEGPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1I8</accession>
    <name>G3B1I8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_103427</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1I8"/>
    <dbReference type="STRING" id="590646.G3B1I8"/>
    <dbReference type="GeneID" id="18245625"/>
    <dbReference type="KEGG" id="cten:18245625"/>
    <dbReference type="eggNOG" id="ENOG502SMTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015493_1_0_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="457" mass="53614" checksum="635396B9B56B6A9E" modified="2011-11-16" version="1">MPISSVEHQKTSNLNFFVELETEAPSPRIFSPIETFQDAYPIFKTPNSFASLYLDYKGMYYLDYFENKLSGELAISFDQTNYFKKLFSLLANNEETFTYVVTAWGALYCKNRLYDDEVREYMNKALKKFNHMFGNKINGFDYYFQLCFYLIISEMHICIGELKEWRVYFDKTCRLINEYGGLQKLCEDFSYSHEIRFMVSNLQYNDIMSSRTLAEGTSFPVEEYEMVFNHPNFKKFELSYGIDTLQGCHQSVLLLLGDIMNHKVILTRELILVESIDKSSEQSLVEYQRAKRDYYQLVESFASKLSAKLETTNPNQEVLKSIENDPSEYEVYSKTYDLYKLCCELYLHLYIKQIIPSNYQIQQIVLECFDLVDILITSKMNLILCLPLLICGVCTFEQGNKAYMKSTINKVRMVSPVQNLDKCWVILQRVWELNPDGNVIVDWSNICDELGWDLNVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1N3</accession>
    <name>G3B1N3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113255</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1N3"/>
    <dbReference type="HOGENOM" id="CLU_1065583_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="261" mass="29832" checksum="A3164DFD8A7D8C8C" modified="2011-11-16" version="1">MNDEEDLLNIPLKKPLFKKKKKVRGSRSARKQSPEVDDDFGDLSVSNGNITITSRKTKPRQTFVRNTEKSTTNVSKWVSGHFKEIEDTAVLGKFTEGDTITGADLEDSEPEPEPNESKRYIEQLVHEYENENDDYDEDIPNNYATIEPQPANDLEINIDDEMVEDEETEAVFVNHQETKSVFVDEDKYDPQIGDSDEDIPSGTVRVIEPLDASQELAKLEKMLQDLQLRKRTAEVQKSLNDKTLVEIDEKRKSLDRVLDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Q2</accession>
    <name>G3B1Q2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_104019</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Q2"/>
    <dbReference type="STRING" id="590646.G3B1Q2"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_4_2_1"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30831" checksum="357D83F03C0DB09C" modified="2011-11-16" version="1">MSFLQNFNTPSLRTTRGFRLKQSSPISSPQPISSSTFPTSPNRYPADQQPQPYQTINLQNDGRNVSSHKDIRSFAEQTLGSQNALYQAVKLPQDEDINEWLAVHVVDFYNQINMLYGTITEFCSPKTCPRMIATEEYEYLWQETNPTMNGSSSPKRPVSLPACEYIENLMNWIQGFFDNDNIFPSKMGAPFPQQFPTLVKTIFKRLFRIYAHIYCHHFHEITELGLQSHLNTSLKHYVLFSKEFDLIQTKDYGPLEDLVDHMLMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B207</accession>
    <name>G3B207_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113342</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B207"/>
    <dbReference type="STRING" id="590646.G3B207"/>
    <dbReference type="GeneID" id="18246912"/>
    <dbReference type="KEGG" id="cten:18246912"/>
    <dbReference type="eggNOG" id="KOG1570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_3_0_1"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="217" mass="24524" checksum="F9B28C68DB876873" modified="2011-11-16" version="1">MSKLTTTHVRENVQKLLQNSTETKKRNFLETVELQVGLKNYDPQRDKRFSGTLKLPVVPRPNMTICIFGDAFDVDRAKSIGVDAMSVDDLKKLNKNKKLIKKLAKKYNAFVASEVLIKQVPRLLGPQLSKAGKFPTPVSHSDDLYHKVQDVKSTIKFQLKKVLCLAVAVGHVEMTEDDLVNQILMSTNFLVSLLKKHWQNVGSLVIKSTMGPSFRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B243</accession>
    <name>G3B243_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
            <ecNumber evidence="17">1.1.99.40</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">D-lactate ferricytochrome C oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_103656</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate</text>
            <dbReference type="Rhea" id="RHEA:51608"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.40"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="EC" id="1.1.99.40" evidence="17"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B243"/>
    <dbReference type="STRING" id="590646.G3B243"/>
    <dbReference type="GeneID" id="18245646"/>
    <dbReference type="KEGG" id="cten:18245646"/>
    <dbReference type="eggNOG" id="KOG1232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_4_1_1"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="19">
        <location>
            <begin position="97"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV64601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="531" mass="58680" checksum="F51E0F9A5E178038" modified="2011-11-16" version="1">MIGLRRLTSVVRPVGSRIVKTGVCKPFYSLSRVNLYSTKTVQLTADTYKDKVSRSPDFKKLEVADIDYFKSVLNDSNSILTDEDDLSFYNEDWMRKYRGQSKLVLKPRNAEQVSQILKYCNEKKLAVVPQGGNTGLVGGSIPIFDEIIISVASINKIRHFDNVSGILKCDAGVILENADNYLGQQGYIFPLDLGAKGSCHVGGVVATNAGGLRLLRYGSLHGSVLGLEVVLPDGTIYNSMNSLRKDNTGFDLKQLFIGSEGSIGIITGVSILCPSRPNSFNVALLGVSSYETVQKVFVETRKELGEILSAFEFMDGKSQILTGRYLKLDHPIESAEFPFYILIETSGSNKEHDDEKLETFLGNQMENGLVEDGIIAQDEAQVKSLWSWRESLPEASNSAGGVYKYDVSLPLSDLYGLVDAAGEKLAEAGLVDMDDESKPVVGAVGYGHVGDGNLHLNVCVREYSKKVEEVLEPFVYEWIQQHKGSISAEHGLGFQKKNYIGYTKNENEIKLMKQLKAHYDPNGIMNPYKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B256</accession>
    <name>G3B256_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_92841</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B256"/>
    <dbReference type="STRING" id="590646.G3B256"/>
    <dbReference type="GeneID" id="18250235"/>
    <dbReference type="KEGG" id="cten:18250235"/>
    <dbReference type="eggNOG" id="ENOG502SA4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067614_0_0_1"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="217" mass="25162" checksum="8B567E8B275094FB" modified="2011-11-16" version="1">MDLFDLPTHLPNEQASSSKPASTSEPGDQTNIESMTVSIESKSATAEGSSHESSASPIYIPGTTIKLETDEDIQKWIAERRKNWPSTKNLERKQQEKHSDKKRKLQEEPSTSSPTTKKPRQICRFYQNNKSCRFGDNCKNMHESETDFKMINNMKVKVPKSFENNYYVKENASENMSLYKMLVKKDQFELENDKFIEFLYYLDKKGLIKHTFNDIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2E0</accession>
    <name>G3B2E0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113435</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2E0"/>
    <dbReference type="STRING" id="590646.G3B2E0"/>
    <dbReference type="GeneID" id="18246958"/>
    <dbReference type="KEGG" id="cten:18246958"/>
    <dbReference type="eggNOG" id="KOG0397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="174" mass="19869" checksum="2147400995ACD703" modified="2011-11-16" version="1">MSAKTQNPMRDMRIEKLVLNICVGESGDRLTRASKVLEQLSGQTPVQSKARYTVRTFGIRRNEKISVHVTIRGPKAEEILERGLKVKEYQLRERNFSATGNFGFGVDEHIDLGIKYDPGIGIYGMDFYVVLGRAGARITRRKRARSTIGNHHQTNKEDSIAWFKQRYDAEVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2H2</accession>
    <name>G3B2H2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_104143</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685480.1">
        <property type="nucleotide sequence ID" value="XM_006685417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2H2"/>
    <dbReference type="STRING" id="590646.G3B2H2"/>
    <dbReference type="GeneID" id="18245690"/>
    <dbReference type="KEGG" id="cten:18245690"/>
    <dbReference type="eggNOG" id="KOG4067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084839_1_0_1"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="208" mass="22763" checksum="DA087D36989EDF16" modified="2011-11-16" version="1">MFGAVCSGRPIQLASQVAENKYVISVPNASNVSHIAIFLLPQTEFNDPNYTALVFFQLPNSTDFKLLGGLNPNKPSGIFKLNNMRPAATTGDNDMMDDEVIDTNDGFTINIGLSIEPTAEAEVQLSQEKMKQSGASSALVPQQPKPYLSNNPSALASMANKIVSHAYNYLSSFVDGQGRVPIKAFDNWWDKFKSKLANNPNFLNELET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2R0</accession>
    <name>G3B2R0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Golgi vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_92976</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2R0"/>
    <dbReference type="STRING" id="590646.G3B2R0"/>
    <dbReference type="GeneID" id="18250243"/>
    <dbReference type="KEGG" id="cten:18250243"/>
    <dbReference type="eggNOG" id="ENOG502QQ2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059017_0_0_1"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="320" mass="35686" checksum="2FA1F89218F6F7CC" modified="2011-11-16" version="1">MSFNFTNFTKDLKNLSDKVTSEFNNEVVPFAQRTSRLVQERIGRVNVDEISQLPSEYTDLANKCNNVEKLYKNVLKITATYESESYDYPSNVQESFQEFSKNITTRVQNLSKATTPAEAQAALISDDRGEFKTPKTLYHALARATDASVLTSSDSQNDPLVKGLDLYSSNLAKIGNARLGQDQLIQAKFNNPLTTTLRSLISQSNSIQKKVEQKRLSYDLARISLTNCTNPSKEPQLRVVMENAEDDFANTVEDAISIMQNVLENARPLEEFLELIRAQLAYHKLATELLGGIVGDFESLIDDNSKASGSGSRESGDFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2Z3</accession>
    <name>G3B2Z3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_105288</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2Z3"/>
    <dbReference type="STRING" id="590646.G3B2Z3"/>
    <dbReference type="GeneID" id="18245794"/>
    <dbReference type="KEGG" id="cten:18245794"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002738_1_2_1"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="10">
        <location>
            <begin position="553"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="668"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="517"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="822" mass="94440" checksum="33419ED6FD993F1B" modified="2011-11-16" version="1">MSKRRLSSPRLFSVKSNDSNSIDDVEFSPLKNKDAHVKIPSIFFEDGMSLLKVSSKSKKRIYFHIDPQTWMFIWNVANKSINPSILPVLNIQKLFTTTTIASKKLQKFTIDDVKKVLYQQEARHFRDELNISQEFENQWITISYFNATKKKMKTLHLIADTEVDAKRFFSTINNLKKLRAQLSDKFYIDLDNMDEEQKELVMMNSTSSPSKPQKEYLSFDDIVKYIARLNINISRNHLRTIFDSLDFKTVVNDVRVINFEEFKEFIALLKRRDDIDHIWDQICGASGASKEMDFRSFKKFISKVQGENFDDETNDKLFYKFCNDTNQWTTESLNQFLLSKYSKPIIEGSHDDDYYNQPLNEYYISSSHNTYLTGRQVADDSSSEGYVKTLQKGCRCVEIDIWDGDNMVTDVEPVVCHGRSFTTSISLRNVLTTIKRYAFVASSFPLILSLEINCSPEAQLQTRNLLLEILGELLVIQPLKGVALLPSPNDLKFKIILKIKKTTPHHLVLTETGSLTSSTASTSFSEDNGSTTSSTSNLSSGKKRKKKQVIDDLSDLAVYVQGQKFRNFSLPESKTFNHCFSLSEKTIDLMLKDETKQKSVDKHNRKFFMRVYPSSMRLRSSNFIPISYWTHGVQMAATNWQTYDLGQQINEALFDGKDKVGYFLKPKDFRKPLVKHTMRNILHLEEKRIKFNITIISAHQLPKPKNKDTVGINPFVKLDVIGARDIHYDNGSAVNQTSIVAENGFNPTWNESFSGTMVANQLLFLKLSLRTMVSKDNDLLLGVFVCRLENLKGGYRYLPLNDALGEELIYSSLLVHIAYDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3C2</accession>
    <name>G3B3C2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial group I intron splicing factor CCM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_130460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3C2"/>
    <dbReference type="STRING" id="590646.G3B3C2"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373834_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF329">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR DMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="78780" checksum="B58F0702A73BCD24" modified="2011-11-16" version="1">MASRHPWMAVATRLQSTVNAGAAGNPAPTPISPDPSANSPQTGRKRPPTHRKLFEIRNQQESVEIFEEAISYLREVQVADVIPSFDIYISFQKLGVTLLRNLIEGKASSEEVDNVLQVLIEHRVVHAIHFCQVMKYNLELADYTRNLRCWVSYLETKNSFGSDSALIDKPFQNVRYDFPSFSYSLVRDLTYYSYFLGSKTDYKFSFEDVKNVLQADNLAPAWRVHDNLEKFLGPSSQLDDFKTSVGRLYYQSVSSDPNSSESLKRMDAYAAKRDGRGLVQFYDSLKGQNLDYKTVHKLMISFYEVGRFDMVYEMFNGLIKKDLKLTKPVWDVMIKSMGHADNTRGLTQESKDELAVNVEKLINTMVEQGFDVDARVLASIVASFSNLNRFDKVDEYLETYSSVPVIHVTKSSYLMGLILNDRVEEAEKKLKQFMGEDSTYAPSASSMNALLDHYSKQNNLDAVNGIIKFMGDHDIAENVVSLTIVADLYFRVTRKRGLVPNVEEMFSLFKKTNTNINMHTYAVIMDGLIKNYNLQAARDIFEWLKKGNHLKKQNSVNIMTIMIKGELDFGDVDRAESLFDEYLKGFANDTQAWNMMIVSILDKNEKAGWNYYLRLQKQKVNNVRPNFYTFYFLFRHFVRKNNRAIIEQLIADLDRAELTSLGKDLPRILRELSTDYVIPTGLKQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3C6</accession>
    <name>G3B3C6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_114159</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3C6"/>
    <dbReference type="STRING" id="590646.G3B3C6"/>
    <dbReference type="GeneID" id="18247295"/>
    <dbReference type="KEGG" id="cten:18247295"/>
    <dbReference type="eggNOG" id="KOG2606">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034963_2_0_1"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22762">
        <property type="entry name" value="OTU_fungi_OTU2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049771">
        <property type="entry name" value="OTU2-like_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="3">
        <location>
            <begin position="162"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="296" mass="34512" checksum="808169958E464422" modified="2011-11-16" version="1">MTTIDYDLAEISYDELVRQHKTQKKQLTAQITGIKKQMTKKNKKELQSQINSLNSQLNSSHQQQLHQWNALHPDHTDESPMSSDTLAHQLSLVTIESESEYTPVVSEATKPKRRNRQKERLAKRDAQIEEIRNQALQESQHSTDFRHAEMEKMNFKLSQRNLSVNEVLPDGNCLFRSIQHQLTVCLKLHKTIEELRQEAASYIRLHPVSFEPFLFNKDEIMSLSDYCTQLESTTMWGSDIEIMAFSEIYECTIEVFVAEGDNLVFGEQFSDQPRLYLAFYKHNYGLGEHYNSLHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Q1</accession>
    <name>G3B3Q1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_134795</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686522.1">
        <property type="nucleotide sequence ID" value="XM_006686459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Q1"/>
    <dbReference type="STRING" id="590646.G3B3Q1"/>
    <dbReference type="GeneID" id="18249814"/>
    <dbReference type="KEGG" id="cten:18249814"/>
    <dbReference type="eggNOG" id="ENOG502SHB2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_376417_0_0_1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF23">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="737" mass="84192" checksum="9D999064977A0E6B" modified="2011-11-16" version="1">MAKDKETTKKDGDSRRKRSFFSCDRCKTRKLACVRLNENLSIYEPCATCKALGLDCKTTIQRKRRRLDIKTVSLINKEYMAKILESLYPSVDFNDTSSLQALHQSITHQDSNEALRYGSFSTAEGAQSEDKEVSYVIYSGKSVNGGISSSSSSFGSQSGSFDRIIYDNDGRSHFMGCFGFTGSLTVLLSTFIRITPHKDINSIKFIAVMNKRGSVISSFSEATEPVIFRNINTKTYPLVCYFSRKEADFYVDKFYQCQQSLLSGMNKQKFTDMYDTFWRINVGELPPHTLSIPQYCCIYVVWITGVGMELYPGTSMQDTYELVNRYINLIKILLSDIFLVPSADGILCLLLLSHFFERNMQVETSYILAQTAVCHAMSCGFHRESVATSETFDLWWSLFDREIKLGFYFGRSSTIPLEQVDLNNERRFKDEDGKYSNSYYLTELHKLAYLFLNHKSQLPTVSKKITAKHLDASLEFDKILIDFYDNLPENFKHFEHIQAQEAEILNSYYLTAVNSGFPFILYPIERTSIVMLPRIKDMVHLIERCIESCISHIKLAAFVQRSEFYPSVEFTTATTACCVMVGLVAGALFYKVTVHAIPEQYKPSDIEDKLKQITRYSKILRILNQQRAMDATGTSRVRRYWVEILNEDLSLLLTDDDSEPNTQTLKTMILGDENGSFDQEHKEGEDIVVESGATDNPENYLNPVSIPNLLDMNNFLDGYLSQQSWMSGVLRDMGISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4A0</accession>
    <name>G3B4A0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_130296</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4A0"/>
    <dbReference type="STRING" id="590646.G3B4A0"/>
    <dbReference type="eggNOG" id="KOG3197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_2_0_1"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="67"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="229" mass="26822" checksum="4BC60CED6CA445FE" modified="2011-11-16" version="1">MSDGHSLMQSHCEWKPETAIPDRVKQLLVPSHPKKPINYILGFIQIVRLLKTQKRTGWLDRDIPENKTESIADHMYRMSIISMLIPNLENKINIDKCVKISVIHDIAESLVGDITPFEGVPKQEKHRRELETIHYLASLVKPYNEPFSKELVELWLDYEEIRCVEAVYVKDIDKFEMIQQAWDYEQDYGIKYDLTEFYASRDAIKTVEVGDLCDEILAQRAEFVKQHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4L3</accession>
    <name>G3B4L3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114010</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686289.1">
        <property type="nucleotide sequence ID" value="XM_006686226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4L3"/>
    <dbReference type="STRING" id="590646.G3B4L3"/>
    <dbReference type="GeneID" id="18247213"/>
    <dbReference type="KEGG" id="cten:18247213"/>
    <dbReference type="eggNOG" id="KOG2659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050392_0_0_1"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="385" mass="44135" checksum="F0B7DC73F6C139EE" modified="2011-11-16" version="1">MTSQVSYKSKIDRLILNYFIQEGYKEAAITFSKETNIELSQEIGVSSLDSRSLSLLEALSNTSPDDQQAFFDQIQNHNIDSNIAKYDPEVNRLVFQDRNTKIVRGYSTINERKEIKYLILTGSITTAIEKISEFFPSVLDSNNLLHFKLLRLNLIEMIRSHKLTNPNTSGDMEKKFLGDILGFVRTNLVNKVTRSYKLLKELEITMSLLCFNFDPSLGSVEHQKDLPEELRSLFDLSLRTQCYKLVNRAILNMNKPSTESYNDLDSITEDQARYEQLNASIGSNGYAVKHIAKDDLEAYLDQDSDSNSDLESVDDETDEMGPVSSKTEGNSIQDEALEDEANKLQTLEFESKLERVVKLWALTEHRMVELNTIKEKRYDLNDEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4T4</accession>
    <name>G3B4T4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113888</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4T4"/>
    <dbReference type="STRING" id="590646.G3B4T4"/>
    <dbReference type="KEGG" id="cten:18245817"/>
    <dbReference type="eggNOG" id="ENOG502RZPK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665828_0_0_1"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="405" mass="46589" checksum="C44924DC1780D717" modified="2011-11-16" version="1">MTIINLIGHFLKENGFEQTFQKFEEEYGQPICTETHELPNKETLNEIINDRFNFKSIQQEISKIDTPLDNKDFKPWKTPYPKNLYLDTDIDQVIVSVDIVLHKNWVLLSTAKQKLIIVDFNGKIVNIFDQIIGRLVIKKIVSDSYDNVYLAGMSGVIYHFKIEGEELTKVNELQVHRRLIVDMKIVEIDSEPYLVSLGFDKLIKLISLRQWDVSASFEISNIPSCFDVINYQNQVVALVGYNENTLLDLVHAKSSKELERLYRISINDAEFTTSNFSPRIIKFNCFDKQLLVAVGTSHEPYMRVMVLPITDFTATNDIRRNQISKNILTMSPQDKFSIPVISWRKDGTGIWVLGDDGILRGINLANDKIIEIPCHNGRVKFVETYDLGGETVVTIGDDRHIKVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4W2</accession>
    <name>G3B4W2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BMT2</name>
        <name evidence="5" type="ORF">CANTEDRAFT_130354</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686315.1">
        <property type="nucleotide sequence ID" value="XM_006686252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4W2"/>
    <dbReference type="STRING" id="590646.G3B4W2"/>
    <dbReference type="GeneID" id="18249444"/>
    <dbReference type="KEGG" id="cten:18249444"/>
    <dbReference type="eggNOG" id="ENOG502R82D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041583_1_0_1"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="307" mass="35314" checksum="830C9F9259BD9EAF" modified="2011-11-16" version="1">MGLLKRNRSITQKQFAPKSLKPQHTRKLIRRFHVLLKNKAIILQKLAWDDNYESVLKGNHKQVYDNGTKTVHSEMFKLEHMNKSELVRTLGQIDGEIHKSGGLEVYQIASQQGQSNKRGSDSSKKLVEWLKSAYELQPHWKALEIGCLSPDNLISTSKLFESVVRIDLNSQHHLILQQDFMERPLPANHGEKFNLVSCSLVLNFVPTPKERGDMLRRITKFLVDPGENILSALFLVIPLPCVSNSRYLDYHKVKEIMEVLGLKERFYHESNKLAYWLFDWSGKTSATSVKKIELHRGGSRNNFAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B540</accession>
    <name>G3B540_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_122940</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B540"/>
    <dbReference type="STRING" id="590646.G3B540"/>
    <dbReference type="GeneID" id="18248935"/>
    <dbReference type="KEGG" id="cten:18248935"/>
    <dbReference type="eggNOG" id="KOG4727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067237_3_0_1"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="221" mass="25024" checksum="61E55A813DA86D86" modified="2011-11-16" version="1">MTEPDSKVSKDQYGRKTWDVDAYSKKTRANNQPQTTTSVHDQINSDRSSSHLLHREKLLKSSINAINTHTIITPTSQTATRGKHKRFGFVCPICDFSFRDNMALIDHFNSPQHIQKATSKNLTTSDPGHEQELIDGGVRHATLAEVESTLKSLSEKFNQSGLTKSSMQQKIEARKQFEQKLQDRKRAKRHKRAMKNKASDSEDDEMGQIMGFSSFKKGAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B552</accession>
    <name>G3B552_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_93908</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B552"/>
    <dbReference type="STRING" id="590646.G3B552"/>
    <dbReference type="GeneID" id="18250339"/>
    <dbReference type="KEGG" id="cten:18250339"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_9_0_1"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="139"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="222"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="473"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="562" mass="61084" checksum="B49F7D4EFD2E75DE" modified="2011-11-16" version="1">MSSSTNSNVLKRKNEDSDSVSDDISKKRVALDGEQIDESLKQEVEAKTAPAIGSSNSSDEEEYDPSVPGLKSPPAVDVATESNESKQASEEPEEEHKSPEHSQPQRPSQPVSTTGDESPSVSHNPVSSVTYQREKEDPTVVSFRMYCPVKEAGLIVGKKGEQINHIRDRANVKVFVSDNIKGVPERIVTVRGSAENVAKAFGLAVRAILDEPEDEASSINSSSYDLRLLIPHPLVGYIIGKQGSKFREIEENSAAKLKAAETPLPYSTDRILLINGVSDAIHIAVYYVAQVVLEHKDALSKQKIVFYNPANYQPNSNPLSTLTGMSPPVNNNMNMNTMGNMGNMSNVGGMNNNMNALSALNSLSSMMMPNNNVMMNPMANAPMGNPTMGNAHMGNSPMANNSMGMQNPQSPYAASKQPYNFQMMFQPSNNPQQNYNSRQPINAPPQQAYTDELGNSMVGEVLTHPLVPSGSGDKYNQDVFVANNSIGSVIGKGGNNIKQIRETSGCTYVKIEPDRGDTMMLGGGRGRLNMRKLTLTGSLNSINTAIYLINQRINTDKERNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B580</accession>
    <name>G3B580_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_98330</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686950.1">
        <property type="nucleotide sequence ID" value="XM_006686887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B580"/>
    <dbReference type="STRING" id="590646.G3B580"/>
    <dbReference type="GeneID" id="18250761"/>
    <dbReference type="KEGG" id="cten:18250761"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050461_0_0_1"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="237" mass="26525" checksum="C6EFE3D07612D619" modified="2011-11-16" version="1">MGKEQNLANHILSLPEPQLSQVRGHPAKVLRLIEDYPESFMDIGPVKGKRIIEEIQKTKPSVMIEMGGYCGYSAILFGNELKKLNGKYYSFELSDEYAEVASKLVDLAGLSGTVEIIVGPANATLPRFKEWLKEDIIDFVFIDHDKQAYTPDLRILESLDLIGVGTTIVADNIIRPGAPEYHSYVTSTPQQKNEYISVNQNPNGSQFVGRWNFVYETELIKMGQDGIDVTKVVKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B582</accession>
    <name>G3B582_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mak10-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_134993</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B582"/>
    <dbReference type="STRING" id="590646.G3B582"/>
    <dbReference type="GeneID" id="18249828"/>
    <dbReference type="KEGG" id="cten:18249828"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022669_0_0_1"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="5">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="6">
        <location>
            <begin position="333"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="81689" checksum="4B323830CE0D32A5" modified="2011-11-16" version="1">MNDYVDITEDFFSSISQISNNRVVKSPFFDLLEGTRAIEINNPRLDTGLIPNELSAAELNFECSKPISESELSGLMNKLFKLLMSWFSSSSLPLTVLSCRYVEDIVHGYTMSLDRGIETFSLGDGVYNRVLKSFVVGLSKFIGIMITVGNTVLYEDEDITTRNMELDFLTDIMVDDVLNDLESAIGLVKRSAAQHKEHIIKQLMLLQDLNSLPILSNLQINLFGVPDLRQLQSFQDILNRGIECLKFIADHKQFYETQELPVGSVSKWVQASLGNRHIPGDVYDIGFDETFKQMTNVFEQLKQIFRKTNYIKDIEALDLFLKYDIQHMVNEYHVINKGIFQLFLIREDQSILGSVYHLSDLTLDLMNHVNVFNCNVSNPKTWNLNNADTELVMDALSQLLKDLEAGVYQNLTVYANNRCRQRQLINKNLLVWDSLQVQSENFEMEIYNNYKIGDKLSDTDENALPISSFIYSTKLELMIEFLLIGIELELYREFEIYSIYWYINYLTKVYINHSTERLLKFNKYKISKIVAKKKKSKNKQELEQKREKLTKINEALQHKIDYWKGFQRLINSVCLLLNYLQNQKMIKFDDLTANFITSFESLFRLRFKPFESIGVPSQLTFAQYSSSFASDVSQDEVINSLNMAKEALVEYNKSVTNDNEKQWISSLVKTCFSYILELKGGKNVFEVSPGYNTYFPKFTAKLPVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5F0</accession>
    <name>G3B5F0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Family A G protein-coupled receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_135040</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5F0"/>
    <dbReference type="STRING" id="590646.G3B5F0"/>
    <dbReference type="eggNOG" id="ENOG502QU8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019464_0_0_1"/>
    <dbReference type="OrthoDB" id="5368598at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442777" evidence="7">
        <location>
            <begin position="27"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="8">
        <location>
            <begin position="50"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="9">
        <location>
            <begin position="404"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="714"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="715"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="793" mass="89512" checksum="B8F3379FF641167C" modified="2011-11-16" version="1">MSRTNTMWGIVAWLMVLSVLTNPVESSVMDVFIRANEINQVQEFTSHETYVQRILAIASSSTSIVFCVASIYFFFAIDPRRLVFRHQLIFFLLFFDLLKAIILLLYPSRVLTHYLAYFNAKFCHIVGFFTATAIEGADFAILTFAIHTYLLIFRPSLNVKVGHSRRTEGGLFVYRHYIYGTSFLIPLILASLAFINGKGYSSFVCWCYLPQTPVWYRMVLSWVPRFVIVTVIFICYSLIYYHVIKEYRVLGGVFTKLPRRDLASEEPSFFSALKYFLGSIKDQLVPKLVLPDAQNDELSRAPSRATDHRHSGGSHTHQGAQSRSDTDEDERTVGGNTSPASENITEVDIDDLSSDDDSDADEVEATQTRHSGNIPSGGEDGRHSNSFNARNDDIQMENLRNFNKRQKIIKKQMKSIFIYPMAYVFIWLFPFILYITQVNYEREHGPIYWINCMGAFMQPFNGTVDSFVFFYREQPWKYTVMKKFEKDHADKMEAVLSKRYSQRSHSLYSSVSTGPAFHRGRALSTSTEYGGGGSNNSLSFNLGVDLNRFKTWRRVLNDINLPLFQLPTEANLATLQKKLISRRAKEISASVNGSKEVETQSDEKVFGENMIHDYSNVLQGKMGEDEFRSTLENFSLNFNKGSNVSLSNTQANSEARAGSNLSPHVASFSHTSNDRKNSIISQSGRSVRGRQHSVVDPNEPVIIEGKAYDAFIGTPVSNTPTHTKNSPSYSKTSRNSYNSGKTIASSKRGNSGSSTPPKKLSKGTLDTNRTSSTVSDEGDEMDFLEFLKKGPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5X6</accession>
    <name>G3B5X6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_130813</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687120.1">
        <property type="nucleotide sequence ID" value="XM_006687057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5X6"/>
    <dbReference type="GeneID" id="18249480"/>
    <dbReference type="KEGG" id="cten:18249480"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_4_1"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="34"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="513" mass="55908" checksum="08025951363B1FC4" modified="2011-11-16" version="1">MSEARSIESTDDTRKESEDLASPIPSPTPDEIGLLREIVFVGLVVGTQLLTQASLAQTIITVGTLSKDFDVTDSPGEQSWFTAAFSLTVGTFILISGRLGDLFGYKKIFVSAYCFLSLSSLITGFTVYTHSVVFFDVMRSLQGLGFSLAFPNALAIFGHYYPMGPKRILFMCLFGAVAPGGFVIGSLFNTTIVNHAWWPWGFWVLAIVALVVAFTSFFVIPKNIVNNSSHRGGFDWVGSVTGVCGLILINFAFNQGPNVGWDKPYVYVLLIVGFLFVGAFFVVERKVKNPLVPKEVMRGETGFVLGCIAAGWSSFGIWLFYTARFLSVLDLLSPMQVTVRYITVLPMGIAAAGLTAVLLPKINVSYIMIIAMTAFLVCNVLIGNRPVGQVYWAQNFVSFLIGPFGMDMSFPAATVILSHSFPKHQQGVAASLVSTIVNYSISIGLGLAGTVEYYTVKGQPDTFEVTERGIRRAFYMGMGLGGLGVVTAIVFIFYERAKDKRKEKASSDAKEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B680</accession>
    <name>G3B680_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_106473</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687198.1">
        <property type="nucleotide sequence ID" value="XM_006687135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B680"/>
    <dbReference type="STRING" id="590646.G3B680"/>
    <dbReference type="GeneID" id="18245890"/>
    <dbReference type="KEGG" id="cten:18245890"/>
    <dbReference type="eggNOG" id="ENOG502RZ9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106811_0_0_1"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="2">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="149" mass="17280" checksum="C2B5E9D1840541AE" modified="2011-11-16" version="1">MAKRESNSESEAKQPTRGVRARTAQQQAQQEFLSKHINSNGPQDKVKIDPLDFNAFTADELNNYSKRYNLGFPECQSLKLDVLNSEIGKKTLSSKKHNKGKRTEKIEKYELSHNLKQHFLSSSVKENEVITNFLYKVRNDDKDFKLEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6A2</accession>
    <name>G3B6A2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114727</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6A2"/>
    <dbReference type="STRING" id="590646.G3B6A2"/>
    <dbReference type="GeneID" id="18247555"/>
    <dbReference type="KEGG" id="cten:18247555"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_7_0_1"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="477" mass="52327" checksum="6C96AD0D837358DC" modified="2011-11-16" version="1">MSDSFASKEEAEKVFGRLKQHPTNQVCFDCENRNPTWTSIPFGVMLCLECSAVHRNLGVHISFVKSSNLDSWQRIQLRNFKFGGNNAAKDFFMKNGGSQYLNKSVEASAKYNSNVAKKYKDKLKQRAAEDAIKNPDVVTLDDLNDAEEVSNSSNSSDSNSNNDFFSNWSKPITTTPSPLGSKNNTPSASTEDLTAPSTTSTPAARKPITTRTSRINRTATSASTLGNKKSSILSSKGNAPRNSRLQNKRINKTEVEDIDFDELERKAKVEAEEAKKLGYKPEEEAEVQYDFSTKPVQSSKTSGSGSGGLSLGGAGATEKERLAPAPIKETTQQFQKLGFGMVVGDNTINSNKKQYKEAAYTGEVSKRFGAQKALSSDEYFGRGPRFDKDAQVEAREKLQKFGNAQSISSASYFGEDEQQGNPQRGRATSGSLRDLESTARDFASKFSGNANQDLDVLKDVLEDGANKVGNYLRDFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6C1</accession>
    <name>G3B6C1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_130885</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687226.1">
        <property type="nucleotide sequence ID" value="XM_006687163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6C1"/>
    <dbReference type="STRING" id="590646.G3B6C1"/>
    <dbReference type="GeneID" id="18249485"/>
    <dbReference type="KEGG" id="cten:18249485"/>
    <dbReference type="eggNOG" id="ENOG502S7YV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070882_2_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="133"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="182" mass="20601" checksum="BFCD2C23ACAE52EC" modified="2011-11-16" version="1">MASQEQVYIEYLNYDWDSFAEFQNGLEEILDNYLQNLQESDPSVTAIPALDKQQLIDQAKSFFYCSHTGNILNLDDFLQWKQQNGDKFVKDHRISEMAETIPENIVQQQLPNITTNSTSPNATTTTTSTDEPPYSSNYQHLVELIMSGTPVPGIKEIPDTILPEKSSTPSAAQRVKPWEKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6R5</accession>
    <name>G3B6R5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_122652</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686792.1">
        <property type="nucleotide sequence ID" value="XM_006686729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6R5"/>
    <dbReference type="STRING" id="590646.G3B6R5"/>
    <dbReference type="GeneID" id="18248915"/>
    <dbReference type="KEGG" id="cten:18248915"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019048_4_1_1"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="87"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="415" mass="45700" checksum="35ACA9F3E6164DF3" modified="2011-11-16" version="1">MYSSNPSYESLKSVPLSHNHSRFYQSSVNPNLSTSNLQNLSSKHSSLLEPTPKKFAPPITPPVSNAGTPVSAGFDVGAWGNGRKRYVAVLCVNWYVASVVSNYTTKMILTDFKHPTTLTQVQFVLNCVLGLATLVVALRRPSVVARFPKGTFPAMEGLSLARFCRPDEFVLRTTVPMGMFQFAGHLTSHSATSVIPVSMNHTVKALSPITTVLIYRGVFNKKYKLITYLTLSPLMVGIMLTCYKGQNAHPGLGYYKGIAYSLVSMMIFVTQNIFAKSRLTVDSAEVLPANASRPERKLDKLSILYFCSLTGFVFTLPVYLISEYTNPRLSLLDMNAFTAMLVAVNGVSHYVQSLLAFQILGLISPINYSIANISKRIIIILVAFVIEGKRLNVVQVLGVMLTCTGLFAYDQYGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Z1</accession>
    <name>G3B6Z1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-mannosidase B</fullName>
            <ecNumber evidence="5">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_122769</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="5"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686846.1">
        <property type="nucleotide sequence ID" value="XM_006686783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Z1"/>
    <dbReference type="STRING" id="590646.G3B6Z1"/>
    <dbReference type="GeneID" id="18248926"/>
    <dbReference type="KEGG" id="cten:18248926"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_1_1_1"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="18">
        <location>
            <begin position="9"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="15">
        <location>
            <begin position="188"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="17">
        <location>
            <begin position="681"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="16">
        <location>
            <begin position="776"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV63053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="838" mass="96248" checksum="F5FA2B6CDD1ED90B" modified="2011-11-16" version="1">MQSYTLKNWSYRQAGTDTWKPARKDLETTEIHPDLFANGEIVDPFVDDNEKSLQWIGEKDWEYKASFDVTDKTASNHLLIFEGLDTFADVFLNGHKILSTESMFVQYQKQVKQYVQLDGPNELRIVFRAALLVARELEKKTFKAKGFNGESSRMQIRKAQYHYGWDWGPLFMTCGPYRPVRFVSYNSRIEDMYAKVSVAKDSASVDFQVSLDVTGPSVLELSVKSPDGHEVHHSKQDAVSGDNSIRFSLQNPQLWFPFSHGTPHLYDFTVSLKSQQGLETVTKRIGLRKVELVQEPFKDQPGTSFYFKVNDVPVYSSGSNWIPAHSFQTCLTKRDYEEWLQLMVDGNQNMIRVWGGGYYEQEVFYTECDRLGILVWQDFMFACGQYPAYPEYIKLVSDEVETQLKRLRNYCSLVLFAGNNEDYQVAEQVGLEWDKSDTSGHYEHTNFPARTLYEGVFPKLVSKFYPEVPYHPGSPWGGQDTADATIGDIHQWNVWHGSQEKYQDWYKLGGRFVSEFGMEALPSRKTYEACITDKSELYPQSYLVDFHNRSDGFERRLALYVIENIKVEGLDFDSWIYATQLMQAECLGYAYRCWRREWRGDGRRYSGGAIVWQINDCWPVASWAIVDHFKRPKLAYYSVRRESRPVGVGMYRNESKDPDPVLDIPDQEGAPFDYRPVHLAVDIWGVNSSLKDVKGTLKVDAYNVSTGERVGGLDDQSVVLKANQTSEFVKNMKISNKIPVVVYSRVVDEEGGIVASAGDWPQPLKYLKFPDRKVEIVVEKDQVVLTVNKPVKGVELSLESDLFIDDNGFDLFPGDSKVVKIKGLKSTDSVKVHYYQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B733</accession>
    <name>G3B733_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114398</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B733"/>
    <dbReference type="eggNOG" id="ENOG502T608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="162" mass="18723" checksum="1453F9DCAA049094" modified="2011-11-16" version="1">MDSIPKSVGVGPNRVRKTKSSMEYVVSQDINAGIKYVLGRVDEDFKYTVYINCTLPTRLYDAVFNGNYNFSHSDTQMKQFNYHKMNNLKDLKEFLETGPEEKTMIVEGFSDIVKLTTMEYARLNVLVVDVLMIMKTRFITCFVLDNKYNPFVDLNCDSHVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7D6</accession>
    <name>G3B7D6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115711</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7D6"/>
    <dbReference type="STRING" id="590646.G3B7D6"/>
    <dbReference type="GeneID" id="18247979"/>
    <dbReference type="KEGG" id="cten:18247979"/>
    <dbReference type="eggNOG" id="KOG1281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_8_0_1"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF110">
        <property type="entry name" value="INORGANIC PHOSPHATE TRANSPORTER PHO87-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="705"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="741"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="856" mass="95213" checksum="9F879F6BB2D7EE93" modified="2011-11-16" version="1">MKFNQSLKFNIVPEWSDHYLAYDHLKKIIYGLQKKQLDLDIEFKLNPTTVSDLLDQLGSDLSKTSSRTSTTSLTRTEIHEDSTSEFKRFKTGASTADAENTEPHDDRSASNDIASCLRKLEAATKKKTFNPLLEFAKQLLMELEKIDQFYAQIYQEINGEYNYLIKDLLTLNEAHIFNYIESEEKEGATKLSRTTSHFTIAEDQAEVDSSDDDADYEHNESTALVNPKNFNVRLQKLVTLKQSNKSVFIKMNELKSFIELNKIGFAKITKKFDKNLNYDIKDDFITNFLVQNSVIFNDTSLIRLNQRIDRIVNSFTFISHRLDPSKSIESIRFELNSYLRDHIIWERNTVWKDLLSLQTKRQDFHLNSDDLLDLSMKKYTVLGVGFSLPRFLVSWQTFKILLAVVAFVVFMAVKTFNDPVEGRALAVLITCAILWATEAIPLFATAMLVPLLVVTCKILRNDDNSVMDASDAAKLILSDMWTSVIMILVGGFALAAALSKYNIAKILSSWILSLVGTKPRNILLTIMMVSLFLSMWISNVATPVLCYSLIQPVLKTLPTDSPFAQALILGIAFASNIGGMASPISSPQNVVAIESMSPNPGWGNWFAIALPVSIIAVVAIWLELILTFKVSTSNVKPFKPIKDKWTVKQMVVLAITLATILLWCVLTKIEDTFGASGIIAVIPIVLFFGSGLLKTADLNNFPWSIVILAMGGLALGSGISSSGLLSTIAQALQKRVEHYDVWVIMIIFGILILVIATFVSHTVAALIIVPLVKEVGEKLPGDHSNLLVMGIALLASAAMGLPTSGFPNVTAISMTDELGKRYLTVNTFITRGVPASFIAYIIVITIGYGIMNALKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7G8</accession>
    <name>G3B7G8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688444.1">
        <property type="nucleotide sequence ID" value="XM_006688381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7G8"/>
    <dbReference type="GeneID" id="18247991"/>
    <dbReference type="KEGG" id="cten:18247991"/>
    <dbReference type="eggNOG" id="ENOG502SECK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100670_0_0_1"/>
    <dbReference type="OrthoDB" id="4093188at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013175">
        <property type="entry name" value="INO80_su_Ies4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08193">
        <property type="entry name" value="INO80_Ies4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="173" mass="18955" checksum="A6B0B96AEE299C45" modified="2011-11-16" version="1">MPPKKYTVKLAVPSKFLATLPVFEVPASKTRVKKLAAEDKKTPAASVDPSVASSKTSSPQPETGGTGGAAGFGSVNNAFNNRINSGLKESSTSGLTMNPIAGQYSLDKSGKPVNRWMKRQTQFKTFTGFKVKYYTWKQKKKDRRESISKKEDKEKVKQEKKVKEVPIVEVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7N2</accession>
    <name>G3B7N2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_108380</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7N2"/>
    <dbReference type="STRING" id="590646.G3B7N2"/>
    <dbReference type="GeneID" id="18246024"/>
    <dbReference type="KEGG" id="cten:18246024"/>
    <dbReference type="eggNOG" id="KOG1933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002359_0_1_1"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="682"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1103"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1166"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1204"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="13">
        <location>
            <begin position="565"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1228" mass="137611" checksum="A00CE4B431E61C94" modified="2011-11-16" version="1">MSVITRVIAHEVHQPGYCAMYGNCGKKSFFGAQLPCPSSTKAVEPDTDSKNLLRDICGADFPVDHVCCSPEQITALQANLKKVDPLISSCPACRKNFYDFFCEFTCSANQSMFVNISKTAVASDTKKEIVTELTQYVAPGSAERFFDSCKNLKFSATNGYAMDLIGGGATNYTQFLKFLGDEKPLLGGSPFQINFAYGVEKNSPMTLRAPSMRDCNDSTYKCACSDCEEACPVLEPFEGLDGHRSVAGLPYLTFASIMGMVAFVVGMGIFHMRIARARRAREAAGFVELVEQTSVEAVLVSQKSGVVEYFKRLDSRFIESIETGFTNLGYFSAKFPGFTILCSLFLIALLSMGMIWLEFETDPVNLWVSPNEPQLKNYQYFEETFGEWYRIEQIIVSRKDDGPILDWKTVQWWFDNELALQEFEDGNETLSLEDFCFKPLGDYCAIESFTQYFGGNILNLDEKNWQKSLQDCTNSPVNCLPTFQQPLKKNLLFNQDDVLDSKAFTVTLLLNKNSKDLEYTQKVEKYENYLKDWLLKLSHENPHFNIAFSTEVSLTQELNQSTNTDIKIVVISYLLMFLYASVSLGGQIPTKLKLKSLLYTRFELGLAGIIIILLSVTSSLGFFSLIGLKSTLIIAEVIPFLVLAIGIDNIFLIVHELKAVNEDFETVDAELEVRVSKALGRIGPSCFISAILQVSMFLLATNVDMPAVKNFAFYSAGAIIVNVFLQMTCFVSLLTLDQKRLEDGRLDCMPWIKVTIAIEEDEYSGNFEYNFSKVLRKYYAPKILSKTAKPKILTVFIFWFGISLSLLPYIELGLDQKIALPSESYLVNYFDSVAKYLNVGPPIFMVMKNFDLSKRENQQKVCGKFSTCEEFSLSNVLEQEYQRGNLSTVVDPLSNWLDDFLTWLNPNLDQCCRLKKNTQEFCSPTAPERLCEVCYLNHDPPYNINMDGLPEGDEFMFFFNEWIQSPSDPCPLGGKAPYGTAVSSNETSIVSSYFRTSHGPLRTQSDFITAYRNSLRIVDEVKSYQGEEAEMFAFSPFYIFFVQYENIIKLTFSLLAVALLLIWVLGTVVLGSVRSASVLAATVVSVLVNIGGILAVWGVSLNAVSLVNLVICVGLAVEFCIHIVRGFTKAEDTIDENDESLNDADGDFIGTESIFKDARTIKTYHTLVNIGGSVLGGITITKLIGICVLAFTRSKIFEVYYFRMWLSLVFVAGVHALCLLPILLSYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B857</accession>
    <name>G3B857_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_126168</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B857"/>
    <dbReference type="STRING" id="590646.G3B857"/>
    <dbReference type="GeneID" id="18249153"/>
    <dbReference type="KEGG" id="cten:18249153"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="340" mass="38165" checksum="57FD2F1464BD2091" modified="2011-11-16" version="1">MQAVPITTKGFGTLSLTGRPTPQPLQHSIETMKYVKHTHGVKFFDCGEFYQFNPEFANLKLARMFCEQENDKDIVLCVKGALNRANMSPDASPDGLKNSIDGVVDFFKDLKVRPKIIYETARVDKRYTVEDVTSRIYDRVKAGDIDGVALSEVSAQTIRKAVAVAPISAVELEFSLVVEDILYNGILAEASKHQIPILAYSPVGRGMLTDYVVEHPDFLSTIPDNDFRKTFDRFQPENFEKNKARSLALYKFAKSKNLSLERLALSYLESLSGLENFMGIAKVTRIIPIPSASSPDKVDRNYSGLVKLSREDIDGIHKIMEENPLHGYRYNAHAEEHLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B892</accession>
    <name>G3B892_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_124743</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B892"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006466_2_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="734" mass="85102" checksum="E6B89B7EB5950B49" modified="2011-11-16" version="1">MTRYVCDIVNCKKSFTRADHLARHRLNHESGSRHRCEWPNCGKTFVRNDVYKKHYREQHEHKSEKTEKISKPSSKPIRFVFMDESKLPKMEPEETNSISPLLNNSSYTQIETPTLSPFTPVDSQEDMNQNIDPANLSINELVSSDELIRWLFGGIENNSDSSSANEPEIPHFPFSNEQTVIDQSIMEGLEDALPSIKFQEDFKGESLQYYLEIYWKYYHPQFPILNKPSFSTRKSHPILILSMITIGAYLSSTLKSDSSRKGRFFSESIAVPLRWAIYKSKEFKPPPKLWVVQSLVLLQTNEICCSSRDLHERANLHRGLSIQMLKRSPMFGGNPWVKPSVNSGENYQKDATIPPYSSQEHWDKWIEDESMKRCALATFYLETLHAVVFGHDMVIDLHDVKPTLPCNEHFWRTGRYSENCLQKPLTLLAAIKSILHKKPVKTRGFGKRIILSGLIALSFEVKDREFEFSISELKSVKQLWQSNIDEAFKFWDLNCSLSAQKNVSPRIWSETYSIPLRELYESYTQMKHYDFMVYAGAPGRMNVEFNEKEVELVTSRIVDWTNSIQGKRAVVLIYSYFCNLLFAGENQEPHNYDPKEDRCFYRKQMISHMLSILWCYNFHSCGPESHDFRWNSENPDHIPSKEDGHAHLQRVKAELTMLAGKPFTTENIYEDVELFAGVLDSVSGRGNMVGLFRIFKTEYLSDSSEIVREHSRLLENCINRSLGSSSIFCSNMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8D8</accession>
    <name>G3B8D8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_107929</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8D8"/>
    <dbReference type="STRING" id="590646.G3B8D8"/>
    <dbReference type="GeneID" id="18245990"/>
    <dbReference type="KEGG" id="cten:18245990"/>
    <dbReference type="eggNOG" id="KOG1475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026535_4_0_1"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="273"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="363" mass="39410" checksum="6B4D04A6DCFDB4F1" modified="2011-11-16" version="1">MSTRPQVSVVSATGEQTSTQLPLPAVFSAPVRPDLVHSVFTRVNKNKRQAYAVSEKAGHQTSAESWGTGRALARIPRVGGSGTHRSGQAAFGNMCRGGRMFAPTKTWRRWNIKVNHNEKRYATASAIAASAVTSLVLARGHRVEQVKELPLVVSNDFESVQKTKDAVALLKAVGAHKDVVKVIKSKKLRAGKGKLRGRRFTQRRGPLVVYAEDNGLVKALRNIPGVETAPVKHLGLLQLAPGAHLGRFIIWTQGAFESLDSVYGSEATKSVKSNYALPSNIISNTDVTRLINSAEIQAVVRPAGQATQKRAHVLKKNPLKNKQVLLRLNPYAKTFSEQKLGSAKVEQPKTKPSKGAFADVLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8F0</accession>
    <name>G3B8F0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_115842</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8F0"/>
    <dbReference type="STRING" id="590646.G3B8F0"/>
    <dbReference type="eggNOG" id="KOG1383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019582_2_3_1"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="559" mass="62813" checksum="009FE601E2AB3CE5" modified="2011-11-16" version="1">MTLTKNPSSYELTKSIVSKVHKTPLNAREEFTSSYDSNKLFPRFHIPNESSDSHLIFKYVTEELSLDGNPTLNLASFVNTELSEPARALINDNLVKNLADNDEYPSLIEFQGRCISMISSLWHAPQHYDEQLRREVPATVGTATTGSSEAIMLAGLALKKSWQERQRQAGKSTENPNILMATCAQVALEKFARYFDVENRLIEISAESGHVIDVKKIKENIDENTIGIFVIMGSTFTGAFEPVLEINNLLDEVEKETGVDVKIHVDGASGGFTAPFTHPNLKWDFSVDRVVSINTSGHKFGLTTAGLGWVIWKNIKYLPENLRFKLDYLGGIEETFNLNFSRAGFPVIHQYYNFLTLGREGYTKLFDNCMNNARVLSLFLEECSYFEVLSVIHKPAIPGSYKLDKIDDTNFHEQYQPGLPVVAFRFSKDFTKKYPEIPQNILSLLLRNKGFIVPNYHLPPGEQSKEILRVVVKSSLSLNLLEKLMQDILSSVELLISSCDSVRNLIAAKDKGKLDHKVVYDLLLSVASNGVEELKGHQKKFHAAKSGHSPHKNSYRGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8J5</accession>
    <name>G3B8J5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_135687</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8J5"/>
    <dbReference type="STRING" id="590646.G3B8J5"/>
    <dbReference type="GeneID" id="18249898"/>
    <dbReference type="KEGG" id="cten:18249898"/>
    <dbReference type="eggNOG" id="KOG0661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_505249_0_0_1"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="539" mass="62111" checksum="62B501122D7F2093" modified="2011-11-16" version="1">MSYMRTQKPLLQKYPQEWVKPIGWKSVFENYYLYTAMGSGSFGDVYLGKTKMNSKIFIRNDIRISTLLEPLHDHHRNRSPLVAVKILKTPITSMEEYRRSKELKFILSIPSHPNLVEVYDLFIDPSSHQVNIVMECMGQTLYHLVVARGSLKFSPVTMKSILSQVLNGIKHIHKYGFLHRDLKPENILLIATIQFYGDKENIPPHRKCDSYIVKVADYGLSRSVDDMSPYTSYVATRWYRAPEILLQRGLYGRAADMWAFGLIVMELVNFAALFPGDNEVNQLWLIVKTLGSPLLPEITYIGTSPTYLIPLGGFWREAHSLASKLKVSFPYERGVTIGELFSTDRYQGVAEVVQGCLKWDPDTRSDAKALSSMKYFKGTCTYESYRPSTHFRQNNHNLFSAGNYGSNSCKVIKPKYLYTDFYDGYEGQFMGFNSPLLPFRNRSYLSKPTTELLDEDHDENVYDPEVSVDVEIDEEYFDSDAYDSDRLEKLLSNADNENENSYHWNGPAEDMIPKLHRHHTRTKTPFHSKDQFLKVPNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8T0</accession>
    <name>G3B8T0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115886</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8T0"/>
    <dbReference type="STRING" id="590646.G3B8T0"/>
    <dbReference type="GeneID" id="18248069"/>
    <dbReference type="KEGG" id="cten:18248069"/>
    <dbReference type="eggNOG" id="KOG3205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076228_1_0_1"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="201" mass="22638" checksum="9FFF93F939CF37FE" modified="2011-11-16" version="1">MSNPQEDDLVPESIEGYVVGEKKTIEEYTNLDAEDESLAKWKASLGLTADGNAYPVKAGDKRKVVIVQMSLTFPDEPELKPIVIDLEDSQGNTLNKEIKFSIKEKSVYQLNIQFRVQHEIITGLKYLHSVKKAGIRVDKLEEPLGSYAPNTTDKPYYERSFPEVEAPSGMLARGSYSATTKFVDDDKTTHLSFPWSFQITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B961</accession>
    <name>G3B961_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_108351</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B961"/>
    <dbReference type="STRING" id="590646.G3B961"/>
    <dbReference type="GeneID" id="18246022"/>
    <dbReference type="KEGG" id="cten:18246022"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_1"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="15"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="565" mass="65798" checksum="FBDDF240CCA69BA3" modified="2011-11-16" version="1">MTINYKWWKDATIYQVWPASFKDSNGDGIGDIPGIVSKLDHIKNLGADIIWLSPMYDSPQNDMGYDISDYESVYPKYGTLEDMDILIDQIHKRGMRLILDLVINHTAAEHKWFQESKSSKTNPKRDWYIWKPPKYDSKGNRQPPNNWVSYFSGSAWEYDETTGEYYLHLFAKNQPDLNWENEHTRNALYKSALSFWFDKGIDGFRIDTAGMYSKDQRFLDAPIVFPDREFQPCKLYHQNGPRIHEFHQEMFKRVTSKYDAMTVGEVGHSSHDEVLKYVGAGRGEMNMLFLFDMVELGSDPRDRFIYNGYNLPDLKTAVTNQAEFIGTEGWTTVFNENHDQPRSVTRFGNDDPKWRVQSGKLLALLMSSLSGTLFLYQGQEIGMTNVPKEWPIEEYKDINSMNYYNELLQEGASDERIAQFMKVLNLVARDNARTPVQWDASAHAGFSTGKPWMRVNDNYPDINAESQYNDPHSLYNFWKSCLSLRKQHKDLFVYGDLEILDFDNQKTFSFLKKSDDKTVLVVLNFTDKEIDFEPLVKGDLKLLHSNYTKVSQQLEPYEGRVYSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9I3</accession>
    <name>G3B9I3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT superfamily oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_108167</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9I3"/>
    <dbReference type="GeneID" id="18246007"/>
    <dbReference type="KEGG" id="cten:18246007"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_3_2_1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="82185" checksum="B8EA2F74F59515EC" modified="2011-11-16" version="1">MPKPHEREPLLGQEPEGPGVFEPTIKDIESDPSALQLPQIVRESVPLNDDPSIPVFTFRYFLLATILVVPGAFVGTLNSFRTTSAAYSIFFVQFASHYLGKQLAASLPSKTIDVGLFKFNTNPGPWSIKETALITVTANSGATGNLATNALALAELHFKDTVSAAVAIPFMFAIVFIGYAYAAICKDLLLYDPEYIWPQALMQSTVLQTQNNTHTSLGQKQVKLLGAALLFMTVWQLLPEFAFPMVSSVAVICYMAPKSKTLNFVGSGLGGIGFLNFTFDWSNITSTIMLYPYWIQVIQFVAFVICCWILIPIVQFTEAVPSFGLMSNSVFTENGEKYPTSQLLTPELKFNSTAYETLGPARLGPQRVWNIFFDYAAYISGITWVVLFGYENLSSSFKKLKFKVTYKDRLNELARNYDTIPRSWYVIMFFISFGTLMIIFGFGQMFMPWWCCIIGLGLGSIIVTPLAWLYALSNFQLPIGTFNELFYGYLVQSREVHPASGSVFGSIAGDAWYRAQYHLECLKLGFYIHLPPRSVFLAQIYGELVGIPVNYLALRWVLSSKRDYLLGNLIDPLHQWTGQDIESTHTNAIQYVVLGPSRLFENYHYLPLGFVLGAVAPYVLFKLHRKYPRFGFNFWNTTVFFSSMSKFYGNISTGGLSKMIGGTVTMFYVFRYHHKVWKNFNYVMAAGLDTGYNLSVLIIFVITSFTVIRMPHWFGNNEDSVERCFALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA14</accession>
    <name>G3BA14_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_94872</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA14"/>
    <dbReference type="HOGENOM" id="CLU_650526_0_0_1"/>
    <dbReference type="OrthoDB" id="4094308at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="422" mass="47952" checksum="C5F7892908F37AF5" modified="2011-11-16" version="1">MENFITVPLRIEDMDKALIKETSVVLNIQPKEDFRLVKAVIPEGTFSGNINIKQWLASKMLSEPDDEQWILLMHKLIPLSQTPGAVNSPPNDDNDNYDNDNDDNDNDSDFTDEKNEKYTNLQLYGKFTMSKESYEDGELKEDFDLVENFLTIYVRSNQTVSKTYGSFKLEEADNESIDFFKWIKKLIYMKDSLTNTVKYSQKRIHSLEFERDEYKKSTEELKANNKRVLDDLMNNFAFILNSKKRKIVELTAGDGGDPLSGLNRKFEADNRSKLDNITIDEKVLDKLPNKLDAKFSGGIKRANKRATRESSKRRQKSAMYEEEQTESGASGEEPTEYRSEEITRNGSNTTSLTDRQIVDVVMGQAVVKHEEDSDATELSGSESDSGRSADSPGSTQRDEETEEGNKDVGKGEVGDSLTDYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA41</accession>
    <name>G3BA41_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_135940</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688175.1">
        <property type="nucleotide sequence ID" value="XM_006688112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA41"/>
    <dbReference type="STRING" id="590646.G3BA41"/>
    <dbReference type="GeneID" id="18249920"/>
    <dbReference type="KEGG" id="cten:18249920"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003293_1_0_1"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057778">
        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="94"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="165"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="552"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="632"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="708"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="791"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="868"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="950"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="1117"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1198" mass="131576" checksum="5DD082AFE8D2775A" modified="2011-11-16" version="1">MSTPAEIIAARIAAQANKASQEDYNDYSDSDVDDGVSSLTASIPSLTDESAFPTLGGGKKPNTTASVGASWGLGGSATASKSPSIGSNGKFKSSTIQEAFSLDADDQLNMDRPEFIKILTTVKAETKTSIECTTSQHTKRRTFLITGKPEDVKLAKRLVIKKLTKPVSTSFEVPAKLRAKIIGPQGKVLRPIISESEVKIEIGAEETFVDGDASNDDIFNKVITIVIYGDTEGCKLAKGRILDIVKDETKNLSIKISVDETVKPFAAKFLQDFIDEQFKELDILVPEFKSSKNVITIIGERELALSAKDEINSKLAQLASKLVIEDVPIPKLKHQFLPIDQILEEENVLIKLLGTGVQFIGEKAKIPVAKEKARQTTSQYKIEVLDMSKAHKGNIPHVSAVAEFLKVQGFFNQVGLKHGVVVNAPSKSVLDTATITSIPIEFVVNSAEVSDENIKAAKKEVVSTVNKLAPDSVKVIDDIDSFLISKVPSAIDSLVKENNITYVILNNRISLFTNDSSVQDSEDFEFEDTSKINEAFESVDAALNSLRELKSDLETVVLEVPGSIQKFVSGRGNTTLNAIIGEVEPHSVAVKLNFDGEIQSEDKLHIHGLKSQVASVQKSIERVINDAKEYGDKYVSTVSIPSTTLSRLIGKNGQFLNSLVNEFGVRIDVAEEEDQKENKKTEIALTGIKKNVESCQAKIVSLSKKWADETLVRIKIESQYHRRLIGANGKFINRLQDKYGVRIRFPSAIELSSNSPDAPKTKDEVTIKGPSKAVAGAKDELEEFYRFEKENGFEQTIEISTKVIPRVIGKSGETINDIADATGVEYQFKRDNVKEEETGVVEVKLTGSKSALKEAISRIQSIVDEAENFVSIDVEVDSKYHRDIIGQNGSKMREIISIAGGDSLPPYKYHKLLNLPNAGSGSNLVNSQGPKEIVNKIVSQLNDLVALKEASVLIEVEVPKEKQRFLVGPSGSTRQALEKEFGVSIEVPRQNDDSAVVKVSGLPEQIEAAKLKIQELTKDDWNDSIDIPENLHWFVSEGGQVFRTLRSNFNVDVGHDNLTRKASKLSNASFPKVPEDSLPTDDDKVKFIIQEREVVDGANIIPWRLKGEKENTVKALKFLQHRLQLAQEADHCAWFYSSKPSSFSKVIGPGGSTVKKIREKSKSQITIPRASDQNSNYIYLVGSKDNLEVAKGLIETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA92</accession>
    <name>G3BA92_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="17" type="ORF">CANTEDRAFT_109802</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA92"/>
    <dbReference type="STRING" id="590646.G3BA92"/>
    <dbReference type="GeneID" id="18246143"/>
    <dbReference type="KEGG" id="cten:18246143"/>
    <dbReference type="eggNOG" id="KOG0188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="16">
        <location>
            <begin position="9"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="721"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV61386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="953" mass="106305" checksum="8564005B9B76AD0E" modified="2011-11-16" version="1">MSTNNNIEWSASKVRTTFLDFFKDKKHTFVPSSSVVPHNDPTLLFANAGMNQYKPIFLGTVDPSSDFANLKRAANSQKCIRAGGKHNDLEDVGRDSYHHTFFEMLGNWSFGDYFKKEAIGFSWNLLVGTYGLDKDRLYVSYFGGDEKQGLDPDLDAKQHWLNIGVAEDHILPGDAKDNFWEMGDQGPCGPCSEIHYDRIGGRNAAHLVNMDDPNVLEIWNIVFIQYNREPDSTLRSLPAKHIDTGMGFERLVSILQDKSSNYDTDVFTPIFDKIREITGVRPYTGKFGTEDKDGIDTAYRVIADHVRTLTFAITDGGVPNNEGRGYVLRRILRRGSRYVRKYMNYPIGTFFQQLAPVVIEQNKEIFPEIAHKSQDLMEILNEEELSFAKTLDRGEKLFEQYSIIASKTPEQTLSGKDVWRLYDTYGFPVDLTRLMAEEAGLSIDEVGFEKAKEESREASKGRNSKSGASLVKLDVHALSELDSNDSIPKTDDSYKYGLDNIKAKVVAIYDGAGFVEVVSDTTSKQYGILLDRTPFYAEQGGQEYDTGKFVIDGQAEFNVENVQVYAGYVLHTGNLVEGSIKVGDEVIAGYDELRRWPIRNNHTGTHVLNYALREVLGNSVDQKGSLVAPEKLRFDFSHKQALKPEEVSKVEDISNEYIKANKQVYAKEVSLADAKQIYGLRAVFGETYPDPVRVVSIGKSVDDLLSNPDNKDWYHFSVEFCGGTHVTKTGDIKDLVIIEESGIAKGIRRIVAVTGTEAHRVQQIAHDNEKELHEINSLPFGPAKESRAKDFGVNLKKLSISVTEKQKLNEKFNKLDKAIKDNLKAIQKEETKKVMDVVNEWLQDKEAKNFLVSHVPINSNAKAIAEGLNLIKKSHPEKSIYLFTGKDKVAHGCYISNDALEKGINVTDLGVAVSSNIGGKAGGKGNTIQGMGDNVGGVDKAIEELTALLSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAA0</accession>
    <name>G3BAA0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_94300</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAA0"/>
    <dbReference type="STRING" id="590646.G3BAA0"/>
    <dbReference type="GeneID" id="18250382"/>
    <dbReference type="KEGG" id="cten:18250382"/>
    <dbReference type="eggNOG" id="KOG4098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113004_1_1_1"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="124" mass="14062" checksum="0A5B3F5277C38040" modified="2011-11-16" version="1">MENEPRSGTDEQKSAALQQQYNKLQADIADMQEQLGTIQAQLQEYVIVDKTLTSISPDHRAGRKCFKMIGGVLVEKTVDEVIKLLDADIKSLQQQRESHEKSVASARTSLESWIKNNHIKIIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAD9</accession>
    <name>G3BAD9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_94920</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688209.1">
        <property type="nucleotide sequence ID" value="XM_006688146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAD9"/>
    <dbReference type="STRING" id="590646.G3BAD9"/>
    <dbReference type="GeneID" id="18250453"/>
    <dbReference type="KEGG" id="cten:18250453"/>
    <dbReference type="eggNOG" id="ENOG502S8V0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132206_1_1_1"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13694" checksum="A83CD49682BB89E7" modified="2011-11-16" version="1">MLGIALLLHCAYSAYEYNKLPISYNRSDLLLELVISLCLIFYSSVTNIQMPSRLNLDNEIVHSPSPYLNFIHINKSLKESNEFGIDDYSKFSNRLDFIDIVKMRREYNVYASSIEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAF8</accession>
    <name>G3BAF8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Aurora kinase</fullName>
            <ecNumber evidence="2 17">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_125535</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573</strain>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2 17"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAF8"/>
    <dbReference type="STRING" id="590646.G3BAF8"/>
    <dbReference type="GeneID" id="18249107"/>
    <dbReference type="KEGG" id="cten:18249107"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_6_1"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="8" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7 17 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="58"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="16">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV62049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="319" mass="36756" checksum="245D08C261675AB7" modified="2011-11-16" version="1">MIRKSLRPLKDTTNVHKDTPVALKPVILKNAVADSLQFLHNSNLTKLKVKPSVSLSHFEIGKTLGKGKLGSVYCVKHKASNFVCALKVMNLETLRSLKLQKNLQREIEIQSSLQHPNILKLFSYFYDSKNVYLVIEYSINGELYHHLRINKRFTNTLASFYIYQVTLGLIYLHSNGIIHRDLKPENILVDFNHTVKLSDFGWSVKIERNAKRSTICGTLDYLSPEMVNSMAYDFKSDIWSLGVLIYELLVGKPPFEHHDRNVTYKRIVGLDLKFPPFVNDEAKELILSLLKTNPSDRLPLEQVLTHPWLMKNKQKWPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAF9</accession>
    <name>G3BAF9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCA7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_94933</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAF9"/>
    <dbReference type="STRING" id="590646.G3BAF9"/>
    <dbReference type="GeneID" id="18250455"/>
    <dbReference type="KEGG" id="cten:18250455"/>
    <dbReference type="eggNOG" id="KOG4140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041816_0_0_1"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="181"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="446" mass="49448" checksum="110D8A602CF8779F" modified="2011-11-16" version="1">MSNRSSQVVTLDSVNSLTNYDSKPIVWKDLGVYLDKKLAVEPKVQSHFSGENSLLSQVIKYKICKSCQRPIGFESLGDHYDKCTQMRNKKNFDDSDDVPIKKRKAKLLEQPETSSIDSSRNTTPQPNGASISSITGKPKKKYKKSQTQKEKEAANAAAAAAAAQDTTEKRKKKSQKPQKSSTKQKGPVDVEKQCGVPLPNGGFCARSLTCKTHSMGAKRMVPGRSAPYDVLLQQYQKRNQAKMAANNALALQKKENDELNAVNTDSDMAAARVLDPDDETYLVLEGLSKNQPIPLERKVILPVRNRHRFLYMRESYANALIINSGAGSQQSQGQSNEQTLANQAISGSIGGLQGRSALVNVDSKRIENDSVTQNSTNISGEMYQVRAPSKEIMLTAQHNAAQQQLFQQQIAKLQQQQLMLMKQRQKRAQQQAQAQAQQQAQAQVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAK7</accession>
    <name>G3BAK7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_109462</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAK7"/>
    <dbReference type="STRING" id="590646.G3BAK7"/>
    <dbReference type="GeneID" id="18246115"/>
    <dbReference type="KEGG" id="cten:18246115"/>
    <dbReference type="eggNOG" id="ENOG502R65X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020084_1_0_1"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="661"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="724" mass="81288" checksum="01D6E515DED7C9E3" modified="2011-11-16" version="1">MSLPVAVVIQQLQEPDSVVPILKSLYTNLNALCHSKAEANHLVSRTLNLMSAHLAYKKWCGVVITEVLVKNYEILSGSGLKFVNALLKILETANQSTDIKLFNATVRCLNKVCDEIRGKPTLTREILTPKLPVIIQLYLNTLDLNPELIIESLYNLMSHHPTTFRPFANKLNSRLVEYLKLDFSSFPSTLKFHISRTYALLPIIEKTDADKVWSNKLNGVINEIVDILSIFKDLIDFSQDSELLSLISNPVFKVIDDARIFPFLQIDISKPETLLQLSTRLETLFSLLVGFISTSLGMCVKFPLGKVISLMEIIFSINTHYLPVKRDIRDEKAKALTRSITIKIQESSLPILNALTTTFQGPMIIYLTNILLVLETSIPMNKKAVDSEEVLNNEQFTTKLLSTVSKILQLVQLYQEPQQLVRFVEAALILVEPRINVNGSSSSNIDKANNTKKTKKKNSQAIPMADLLSHSHLFDGEIPAETIDTVRTFVNSVITRTELPSTQHYKIMRYLIIEAVKSTHFSYNNSMSSELKRLLINAVTYPGFEKVSLLPIVSSIMGDDPLISVFNNPRFPPVPQLIDKSVESDSEEEEEEEETTVLPETNVLSDILNKRTFEYANDTVDTDGKRLKTEQKVPQIHLQDQSESISSLKYQPQDVLKFKESDTPKVAAKSPHQVSNETNTSKHIPVTQMSLTPSHASTDAGEASGDESDFEMPQIDIDGDSDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAP0</accession>
    <name>G3BAP0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94956</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAP0"/>
    <dbReference type="HOGENOM" id="CLU_1019405_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="273" mass="31486" checksum="9E57E79C263784CD" modified="2011-11-16" version="1">MVCDSPVAVSRDSMNCDCTISDPSVPSFSQDHSFNSLSAQDNLGVLPVQTPTTSSYQENTSSSRNNNFFQPSNSSSSAACTVESNYHLKYNVGTPVPHGKHVPSVVICQRLGSRGIPPSIFLLHQREDNSHWLSHKIVLQRMGKKFQDFLESDPQFQGFLHNSQERAIPSVKELVHNFIRVISKFFQGYNHLDSRKSVSHYLRKISCWELELHRGFWTIERCFEPPKEDHTKEDWIKFEKKFYCHKSQLLRYQIGVLGEFRHLLEIQSRTLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAQ5</accession>
    <name>G3BAQ5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xylose transporter, high affinity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_107932</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAQ5"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="426" mass="48134" checksum="898E92208AACE346" modified="2011-11-16" version="1">MVGGSLQSFAVNLYVFSVGRVLSGFGVGILSTMVPSYQCEISPSEERGKLVCGEFTGNITGYALSVWVDYFCYFIQDVGDARKNPHTFAANLSWRLPLFVQVVIAFVLFIGGFFIVESPRYLLDEDMDQQGFNVLCLLYDSSLEHNKPVKEFFLIKNSILNERITIPKFERSWKNMLKNYRTRVFIACSVFAFAQFNGINIISYYAPMVFEEAGFNNSSALLMTGINGIVYLLSTIPPWFLVDKWGRKPILVSGGIAMGICLYMIAWMIWLDKSYTPNMVAMLVIIYNAAFGYSWGPIGFLIPPEVFPLAIRSKGVSLATATNWLANYIVGQMTPILQDSVKWGLYLFPATSCVISIVVVVIFYPETKGVELEDIDRVFNEFYNTKGSQPQMNEYFRVDEATEMAGDGLELDELDYETDFQRRDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAW8</accession>
    <name>G3BAW8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114935</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAW8"/>
    <dbReference type="HOGENOM" id="CLU_2960544_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="59" mass="6993" checksum="38A19F94BA28902D" modified="2011-11-16" version="1">MASVLKYARKGLPLYVRASEIERKFIMYATIFKFYWIDSKETHKRAENTVNNAYGVFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB19</accession>
    <name>G3BB19_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Modifier of transcription 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_125677</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BB19"/>
    <dbReference type="eggNOG" id="KOG0392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_1_1_1"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1296"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1658"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV62123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1883" mass="212020" checksum="5DD2348BD2B6B32E" modified="2011-11-16" version="1">MSRLDRLVILLETGSTQFIRSTAADQLSDLAKGHPEETLNLLGRVYPFLKSPKWETRVAAARAFGNIVNHSRVWDPNNEHDDDSNDNDNNDNDTKNGTSTIKEDPDVDMETEGVDGEIKIKSDPDAEFKREQDEELKKMDDNLSSLVTFESWDLIEILKSNRKLLASSINEIDTSNVNEAEDEVSLLSKFKRHKNNNSIKIEPEKEASKEQAAKALAANARLKALQKRRAKVNAKSGINRTKPIDLSQSSISKQMMSDPNAINTNIKQEVPQFDLTSQQGGEKLVMETKAELSPILSQHAKVAGLVWQFQGVYELLVDDLFDDRWEIRHGACLGLRELIKKHGKSAGRIKSKSLEENIKNNDATLEDLAVRLCTLFALDRFGDYVSDSVVAPVRESGAQALAALLIHLEIDPLIKTFDALHRLILQEGYFPKCWEAKHGGMLGLRYFVSVRTSVLTEKPELLNDTVSMVLHGLQESDDDVQSVAALTLAPIASDFIKHKRELISVLLKTIWDCLVNLRDDLSASIGSVMDLLSKLCTHQEVIEIMEKQAAKDQSSSFESLVPRLFPFLRHSIVNVRKAVLRTILEFLSIDNAATKHWINSKALRLIFQNLLVEQNEEVLNLSQKVYTRLIEEINVNEFLNAEELFSSNHGPLLFLTMTPIGLARHNYQMNTNLIMRPSGKMVSNDGRKRKNSESKAKSDIPYLDELKVNIDSHIFKGDILLLGVDVFIRTRAAASKAFGQTLASIKDEKLLITVLDSLSNYFKSKHSSPRLLSSVILEEYAKSLKQQNLPIPDQVKEKFLPNLIGVLAEPAFPSLPHFRELVPTLKALRTSCIHLFDIFINMAKISPNKIPQLPVVVQGESEAGPNAFSIEQAQKLIDETYPKLIKTLSPTYKMASINALEDARHRITLAIDDVSSARLSRITSILAAYAAAVLAVDGVPKKLNPIIRSLMDSVKQEESALLQKRSAEAVSHLIQELNNVGKKGAADKITKNLCGFLCVDTSEVPEYHHNAEFKDIVLSLKKEEAKTDPVDIAQHEKAVHEARIKRNGALLSFDALLDVYQDTLFENLPKLKELIIEPLKLLQHADDEEFQKDELKGQSIIDALGILRALLPKLHKSLHKTITDNLPLLLPGFTSELSVFRYSTAKCFATISYVCQVPAFTFLVKSILPLLNNSGTIKERQGAIETVYHLSTTMGSDILPYVVFLIVPVLGRMSDSNPDVRVLATTTFASIIKLVPLEAGIPDPEDMPKDLLEGRDREREFIQQMLDPTKIKSFDLPVSIKATLRKYQQDGVNWLHFLNKYHLHGILCDDMGLGKTLQTICIVSSDHYIRDEKFKETQSREFRKLPSLVVCPPSVTGHWEQELNQYSPFLKVMVYAGGPSARQGLRAQFMDNDVIVTSYDVCRNDVEFLNEHDYNYCVLDEGHIIKNSASKLTKSVKRINAEHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKVFNEKFAKPIAASRNSKTSSKEQEAGALALESLHKQVLPFMLRRLKEDVLSDLPPKIIQDYYCELSSLQKELYKDFAVKQKSTIEQDIKDGIMDEENNNKTHVFQALQYMRKLCNHPALVLSPNHPKYNKIMVDLNNKKQDLRSIEHSPKLLSLKTLLLECGIGSSDSDYHSKSYREKQKQNQLLSAEGVISEHRALIFCQLKDMLDIVEEQLLKKVLPSVTYMRLDGSTDPRDRQKIVRKFNEDPSIDVLLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRAHRLGQKKVVNVYRLITQNTLEEKIMGLQKFKMNIASTIVNQQNVGLSSMDTNQLLDLFDVEDNGNKIEPVEEEKKEIPDDVSGGLSGKAADAVGELGELWDEAQYEEEYNLDNFIKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB80</accession>
    <name>G3BB80_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_94401</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB80"/>
    <dbReference type="STRING" id="590646.G3BB80"/>
    <dbReference type="GeneID" id="18250393"/>
    <dbReference type="KEGG" id="cten:18250393"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="404"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="840" mass="92426" checksum="03FF5C15512BC24A" modified="2011-11-16" version="1">MVKTLDVDSLIDQLTLEEKISLLAGNDSWHTVPIPRLGIPSLRVSDGPNGVRGIKFFNGVPSNCFVCGTGLAATFNKSLLKNCGQMMGQEAKARGVHCILGPTCNTARSPLGGRSFESYGEDPVLSGYAAASIVAGIQSEKVSACLKHFVCNDQEDERKAVDTYLTERALREIYMKPFQIALRDAHPNVIMTAYNMIDGEHVSQSKRFLQQILRHEWKFNGAVMSDWFGTYSTKEALDAGLTLEMPGPTRFRQIVQTSHKVYSNEIHTDTIDQNVRDLLNLVNESIKPDIGENIVERENDDPAAEALLRQSGAEAVVLLKNTGILPLDKKTPQKIVILGPNAKVCQDSGGGSASMAARYKITPFEGIVKKVKEGGNKATIEYAIGAHLDKNLPDVADVLVSKGGNSGSISVTFYQHPSGVEDRNELTSFEMTTTKVFLADFKAPKLDPNELLYYADLEAHYKAEESGTYEFGCSCLGSAQLFIDGKLVVDNKTKQVRGEAFFLGMGTREEKSDVQLVKGQTYHIKVEFGTSPTALVAKEFKEPGGVYFGFRLKSTPKDELAKAVQIAKDADTVIVVAGLSKEWESEGFDRPNMDIPGYTNQLIEEVTKVNSNVIIVNQSGSAVTMPWIDKVQAVVHAWFGGNETGNTIADVVFGDYNPSGKLSMTFPKRVEDNPAFLNFGSTNGKVWYGEDVYIGYRFYEKTKTDVLFPFGFGLSYTNFEFSNLKIKPVKSEIHVSVTVKNTGKIKGAEVIQVYVSPVESKIPRPIKELKNFDKVELAPGKSVSVTIPISIKEATSYWDGYKNKWSSDKGTYKVLVGNSSDNILVEGEFETDKSFNWLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBB9</accession>
    <name>G3BBB9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_115012</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBB9"/>
    <dbReference type="STRING" id="590646.G3BBB9"/>
    <dbReference type="eggNOG" id="KOG0338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1081815_0_0_1"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="186"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="257" mass="29457" checksum="DCB958525C6F59C1" modified="2011-11-16" version="1">MSRIVVFVARKETAHNLRIVLGLLGLKVSELHGSLTQEQRLENVSNFKNLVVPILICTDLAARGLDIPKIELVINFDMPKSYEIYLHRVGRTARAGRDGISITFVGESSQDRSIVKNSIKAITENPGNGKAISRSADWKQVEELNKIIESKEDIIEEVKEEEKSAKEIIQAEMELNKASNILKHKSEIQSRPRRTWFQSSEEKNPTSAMHQLTKHGKKVNHNKRKVIEERKDISRPYKKTKADRMNKDVKKSNKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBE9</accession>
    <name>G3BBE9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein LST4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_95064</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LST4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688343.1">
        <property type="nucleotide sequence ID" value="XM_006688280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBE9"/>
    <dbReference type="STRING" id="590646.G3BBE9"/>
    <dbReference type="GeneID" id="18250473"/>
    <dbReference type="KEGG" id="cten:18250473"/>
    <dbReference type="eggNOG" id="ENOG502S2BV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007917_0_0_1"/>
    <dbReference type="OrthoDB" id="4063558at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037545">
        <property type="entry name" value="DENN_FNIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041153">
        <property type="entry name" value="LST4_longin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18639">
        <property type="entry name" value="Longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51836">
        <property type="entry name" value="DENN_FNIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UDENN FNIP1/2-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="945" mass="103225" checksum="C3B6610A6386A638" modified="2011-11-16" version="1">MLGRLFRQQSSSSLHKEPPPASSSGLGTSANSYEDSYTREILYGVSEKRILNPYDLNSKLFRILVSQDGGSLRSKQVLFDSAHEDKPLSAAPKSNLTRSIMSPKIHHNPNELHDYMFGCGLPTNELHSITKIHMLPVSSQYGSSRCVLVTRLFSITDFQDSTISPGSPSSNESQEIGVWCPRPTLPINTTKISVHPSSTASVSATSTKNNVTSRFAVGLIIPLDDNVTEVIANNWHEICHFLIVLQKTVSKKMIGVINQNEHMPYIQNKRIQFPSYILANDMDIQSNLLKLIKLINYNANIPKLVNSNSLMKLCLRDTGVSKYNPMVLNWVLEILNWLEFKELNESSKFLSSLLALVISYRYSLTERPFSHDYSSRGKEITRIVVMTGNPMVAKKLMFILNGMIADEDVLNMLGGTTGSLEKQISLDNFRSPLEEAVDIGGTVPNSPTQETDVDTDIDEEDEEEIENISSPSSPTSSPPLFAAHPIPIKSKPSQSFSSSENSFSNISHKGWEIPGKATPVTSTSVSNSSTPVPKNIPISRPQRGSLSKSSSMAYLSSSLNSSLSSSASNYSLSKLGGSFIDKWRNQFNSSVNYDNIDYQPPGHGSFGGHSFGGNSLGKPYGGIGRKLTSQTMKTPSPALEIEGFHLSPSSSPSPVLSATPTLPSPISNGGPNGSPALLSTIPTGIRSVSKTQSMFDLYHADSFSGKHSTRLETNAISRSKASIYENHQFTANSLKINRKIDHIMETAPHFEVASETTLNVPEPDPFPAHQLAAYEDLPPSVAFTDEFRPEFVLQSCPINPRLEQQIISSMKNDLLFHQNNCHVDNITTRTIFVSLRAREVKLIEMKIGDDPSTVVTTPAAMSTSPLGSYFPEPAVPRRSAAPYKTTVKKVYGPGKHQGDGALVGLVEQNLHAMRELLARGADSGVSQSSPDFSAALCALVSNLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBI2</accession>
    <name>G3BBI2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_108535</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBI2"/>
    <dbReference type="STRING" id="590646.G3BBI2"/>
    <dbReference type="GeneID" id="18246038"/>
    <dbReference type="KEGG" id="cten:18246038"/>
    <dbReference type="eggNOG" id="KOG0989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_1_0_1"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="54"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="359" mass="40392" checksum="B7C625EC91D9452B" modified="2011-11-16" version="1">MVSEAERSTRNKAYEQEKIEHTPWVEKYRPKSLDDVASQDHTVKVLKRTLVSANLPHMLFYGPPGTGKTSTILALAKSLYGPILFKSRVLELNASDERGISIVRQKIKNFARLTISNPSPEDLEKYPCPPYKIIILDEADSMTNDAQSALRRTMETYSGVTRFCLVCNYITRIIDPLASRCSKFRFKPLNNSDALGRLQYIAGHEGIEAEEGTLEEVLKISNGDLRRAITYLQSATRLHSSLKLLEEDISIGTNKITVDSILEVGGVVSDEIIDKILSTIESKDSKEIIEETRNVVLQGYSAQQVIDQLHDKLIMDDSRSSIVKNHVSQLLFTTDKRLNSGTDEHIQLLNLFLKVSQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBS1</accession>
    <name>G3BBS1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115687</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBS1"/>
    <dbReference type="HOGENOM" id="CLU_3068483_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012589">
        <property type="entry name" value="Pmp1/Pmp2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08114">
        <property type="entry name" value="PMP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442621" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="53" mass="5798" checksum="F47D2C12B95570B9" modified="2011-11-16" version="1">MLPPGVILVFVLVFLAFCAVVGQKIQPKILSVFQSGKAFRHCCSNHCYLSTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBW2</accession>
    <name>G3BBW2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcipressin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_126964</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBW2"/>
    <dbReference type="STRING" id="590646.G3BBW2"/>
    <dbReference type="eggNOG" id="KOG4019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113368_0_0_1"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24345" checksum="8E8CBCAE788CD94B" modified="2011-11-16" version="1">MVRFPTNTLIITQVSDAFLDDPNELVKFLASHNITCELVSLRRFGRILLICDDHQVSQSIRQLLQNSPQWSHLAVTFSLQDNELTSGREVSEKMDYLELPAQDGSRRFLISPPLSPPPEWDHWDKVEEGPHRTAMTNPEELSHLLWERLGGVNSTEVRRFQAEDTRDLKIEPQVVFEDIDNDVPAILLDRVDYEQPSGPSKPVFKTSLPPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC60</accession>
    <name>G3BC60_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_95592</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC60"/>
    <dbReference type="STRING" id="590646.G3BC60"/>
    <dbReference type="GeneID" id="18250520"/>
    <dbReference type="KEGG" id="cten:18250520"/>
    <dbReference type="eggNOG" id="KOG3432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135754_0_0_1"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="125" mass="13730" checksum="58AF2F28D072672D" modified="2011-11-16" version="1">MSAVSDAMSKRSLLAAIADEDSITGLLLAGVGQVSGEDGKETNFLTVTPGKTSVEEIEEAFETFTTVRKDIAILLINQHLADLIRHRVDSYTNAFPAILEIPSKDHPYDPEKDSILKKVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC81</accession>
    <name>G3BC81_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116162</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690241.1">
        <property type="nucleotide sequence ID" value="XM_006690178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC81"/>
    <dbReference type="GeneID" id="90981866"/>
    <dbReference type="KEGG" id="cten:90981866"/>
    <dbReference type="eggNOG" id="ENOG502SFEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1886514_0_0_1"/>
    <dbReference type="OrthoDB" id="3995860at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="133" mass="15288" checksum="4E15BA0BBB1BD639" modified="2011-11-16" version="1">MGICLSCLRPSEEDDEYNERSSLLRSQDFYSDEHLQEELLKKQQRQQELNNIVNELSENLIDVSTFMSNSTLQSSSTPNTPNINEYGASQDKQYPYSISPNERAKILEEVENLDPAVKEACKVEVKDSLYLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCB9</accession>
    <name>G3BCB9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_116864</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCB9"/>
    <dbReference type="STRING" id="590646.G3BCB9"/>
    <dbReference type="GeneID" id="18248477"/>
    <dbReference type="KEGG" id="cten:18248477"/>
    <dbReference type="eggNOG" id="ENOG502S52R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091441_0_0_1"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="208" mass="23628" checksum="2775598D7FCE8A1D" modified="2011-11-16" version="1" fragment="single">MLQGNPEELIQASIESFEIQPDLQTLDRIDENIVKILNKRAALLKQYGDTNGDLQEQISKLQIDVQELVRTNNYPQIHDGASPVDTDVFTYISSKLDELKNLKVSISKNLSDLNVLISSNNRSKLKLTDSLTTLNDNYHSLINKNLGSHKNSNVMKINLYKSLGLVIESKGEEDNILVYNEKEGTSGFLKVDEQYSDYFIGNYIWDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD69</accession>
    <name>G3BD69_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_111698</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD69"/>
    <dbReference type="STRING" id="590646.G3BD69"/>
    <dbReference type="GeneID" id="18246307"/>
    <dbReference type="KEGG" id="cten:18246307"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000588">
        <property type="entry name" value="CTD kinase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="180"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="494"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="564" mass="64067" checksum="21777B5F70CB0723" modified="2011-11-16" version="1">MSDRYRPPPTGPKGKRNYNEGSHPADRRPRPAGDKFTPTGPKRFQERDNYRPSSDSYKSNQNPNHSQRSFPTGPSGAKPSASGTRSAPPAGPSGYKSGTPGAGSKPTTTSTNGNYYNNTNKRHSGNFSTAKYDPLNKKPKFNPGALSRVPAVRQEPLKIPTKLDKNQIYSIRTARSSEIFQRTQQVGEGTYGKVYKAKNQVTSEFVALKRLRLETEKEGFPITAIREIKLLQSFDHKNVIGLLEMMVEQNQIFMIFDYMEHDLTGLLTHPELKLEDCHRKFLFKQLMEGTDYLHQKRIMHRDIKGSNILIDNIGRLKIADFGLARPMKIVKDGESPDYTNRVITIWYRPPELLLGSTDYGRQVDIWGVGCLLIELYTKHAIFQGYNDEVSQLHKIFNIMGTPTLEDWPDIQNLPWFEMLKPKINKVSNFEVLFKHSMTEDSFDLALKLLQLNPNKRLTAHQALNHHYFTKDPKPEPLFFLKELKGEWHEFETKKLRRKERKRLQDERERQKASGEVPGTASSRPNASPNTGMRSIPIPPSAPHTGPQTAPNSGGNDVEMTDPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDF5</accession>
    <name>G3BDF5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_137417</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDF5"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015387_0_0_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="534" mass="62422" checksum="486BB1D9B7F90CC7" modified="2011-11-16" version="1">MEKTFNLSHNRKPVFYGFIAIWLISAGIWVYVYTPIDFSESETSIYHSELRAPNADLSNPLNVKKIDVFEDCTIQKLVRTLGIEDTRSIDSHSSVYDQMLEKRALSDILTNLDFTERCNLYFKNLFVRDHNWFVDPNEDFPLEHRDAFDLQSFKKETSERVREKFAQMLNLEYDKINFDDENVRKEVDRLTEEEFNEFWERTMKTEQKIVDYLSHLRIFNKCYVTSDNRYIMSKANELIEKEANSIDHTEFKADDDESLINDSGSKSCSELESRIYKWVSHSYPIYERWTGEIFLSPPDLRKFVRHPEVFKTTNSKFKGFTERPSKSASTLNGPCFFNKFKNSLNGKGIVLSIGDKHVDDIVRLIRLLRALNNHYPIQIVFYDSLSDETKARIVAAARNKMVDLPESFHKVSKHFPPDYLNVQDGGLPKQEVWFVNTYNAIHDHFKDKFKRFANKFLATLFNSFEEFMLVDADTTTELKSQQKGGTWKVDIVIVIYGGLTSDGQDNTQVGRVFEFDQDSIDLSSYFGDIWVGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE38</accession>
    <name>G3BE38_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar pre-ribosomal-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_136931</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689664.1">
        <property type="nucleotide sequence ID" value="XM_006689601.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BE38"/>
    <dbReference type="GeneID" id="18250021"/>
    <dbReference type="KEGG" id="cten:18250021"/>
    <dbReference type="eggNOG" id="KOG1791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003174_0_0_1"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="1">
        <location>
            <begin position="27"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1370" mass="159136" checksum="D06481185CC48F2A" modified="2011-11-16" version="1">MSVSVFEPSILLNTETFVKFTESGDLKKLLGQWYHACKTNSHSQVVTFLGYLRSITNKISSESIHNDQIKQFYLEFVDPTNIKMVYRCLNQKKNSITIPTLSILQDMVSYRLVNDLLNGFDISTNILPGLLLKEDSIRSNFIRFWLHLNTHMNYFDRMNYLGLKVWINIFKYMANDPPEIVALLVQFLEAKILNEPAFRRSTKLKLFNETCLFNLQANMDKFKLFPLFKKIVDPKTGILFLDAPNTTATVNNKTFRINNKVLYNLLTFVKLDSISKVNLVHLILSKDYKLIDPYMNRLLINGGYHDPNLTSWYLSHTLLYTKILQLPTYDLQNVLLKPLSKASLTKGIKSKSNLIIQLNLQIIYLMLKKLDHIEDQLVINSVFKNLPELSDLIISSNVQTVNLMVLKILEIYSKYQNSLNTSLNKYVSTILSEATENFTKLNLIKLNFIISIQLNLSNKFDLKQNSLILKLVKFSIIDKNASFFHDMINKLVEIPKVTLLNPMYSLLYSQVPEELLPSLNESLTRLNNPYSYYDLPIETNVFVKILVEQFSIYFKKNNNSGLEWFEKFLTNLCIIGEDFNQLKMLLDHFGIKCNPTLQNIEDPSIIKNDFELLSVIYNIKLSTSENYIVDAFGRLQNYTVSNSEFVSNFSNLSFFKLLAFEDDFKLQCFNQLIKPLEIDFNSEIKSYVFEKLKSTSSFSALSWILNEEQLNYQGFNEDIQLVNFELLISRNQKPNIEIEKLFRFNNDKKYDIIKFLLTPDNVSKHIGKIIVSGKLELLNEIELDCSSIQYLNQLDLSNIELCKIGAALLPTESLADFYKNINVSETGLSFYQFLQLVWKSLPFRSFDSDIVVSLLQKASNYSDTFCPAFVNVLNELKVHNKEWLSNSMIYITKQFAERDELSDEFYDFLEQYIKLLPVSVPVNVINSQLEVLLSSKYINSKFLSYMNSVILSEPRIDFDKMLTLFMNNPNNCLNEFSHPSKQFTRIESSLVVYNLFNLGASHSVLNNLIYWYNGSIAFEDLIIKKILVKMESVQQKSWMTDRWNWEINDFKESDFDLVGKQPLFSNDLISLNKNFISNCSKNYQPLDVPSQYKEIVDFVNKNYFKVNYEYSETVYDYEFLLLLTINNEEFFKSQDETLQVNMKNLIEYSILEILVKNFNSPLCKVIVGNIIKNIDNDKGFKDITLFKIYLSNLFNCSQLTGVQLTLYANLIPILSNPGHFLYELVFKYVTSHPRIGPKDMPLFFKIKSESLKTIEWYISGMTITTDDLQLLNTNQFFEWILTLLNTPGKVESLHKTILKTIFMLPDINYGSLSLITRNGILSYLEQISSGHTNLKLNLQEIAQKLEISASKRTLEWSNYDLVNVSKRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEB3</accession>
    <name>G3BEB3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="9">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="9">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEF1</name>
        <name evidence="11" type="ORF">CANTEDRAFT_95952</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689723.1">
        <property type="nucleotide sequence ID" value="XM_006689660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEB3"/>
    <dbReference type="STRING" id="590646.G3BEB3"/>
    <dbReference type="GeneID" id="18250559"/>
    <dbReference type="KEGG" id="cten:18250559"/>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_0_1"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="68"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="762" mass="84523" checksum="6DD77AC21E92893F" modified="2011-11-16" version="1">MLVRNLLNASKAFSKPVSRVSIQQSMMRPFSYTSRVLSEVQPKTYEEEKVIIDEINNKLTDKDINSSKKLRNIGISAHIDSGKTTFTERVLFYTGRIKSIHEVRGNDAVGAKMDHMDLEREKGITIQSAATYCSWDKDNQSYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVSGVQSQTVTVDRQMRRYNVPRITFINKMDRMGANPFKAIEQINLKLKTPAAAIQVPIGAESELKGVVNIIDRVALYNEGPQGEVIRTDSIPEDLKDLVEEKRALLIETLADVDDEMADIYLEGEEPTVEQIKSAIRRATIGRKFTPVLMGSALANKGVQPVLDAVVDYLPQPNEILNRGLDVTTAEEKPVNLVPSSSEPFVGLAFKLEEGRFGQLTYIRVYQGKLKKGAYINHLKSGKKLKVSRLARMHSNDMEDVEEVGAGEICATFGIDCASGDTFVGANSEQKIAMSSMFVPDAVISLSIHPKSKDNGSFSRAINRFQKEDPTFRVRFDAESKQTIISGMGELHLEIYVERMKREYGVECITGKPQVAYREAITAPTTFDYTHKKQSGGAGQYGRVIGELKPLVGENKFSESIVGGKIPEKFLFGCQKGFDDSLDKGPLIGHKVLGVHMHLNDGQSHMVDSSEFSFRTATQGAFKQAFLNAQPVILEPIMTVEVNAPNEYQGSVVGLVNKLGGLILETVNNQEEFTVTAECSLNSMFGFSTSLRASTQGKGEFSLEFLKYSECPPQLQRELVAEYQKSLQAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEB8</accession>
    <name>G3BEB8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavo protein WrbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116575</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flavodoxin-like protein (FLP) that plays a role in cell wall integrity, oxidative stress protection and virulence. FLPs act as NAD(P)H quinone oxidoreductases. Reduces ubiquinone (coenzyme Q), enabling it to serve as an antioxidant in the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEB8"/>
    <dbReference type="GeneID" id="18248359"/>
    <dbReference type="KEGG" id="cten:18248359"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="5">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="201" mass="21765" checksum="EC2BEF49EA04B2CF" modified="2011-11-16" version="1">MAPKIAIIYYSTWSHVYQSSLEIQKGIKEAGGEADIFQVKETLSDEVLTTLYAAPKADVPEATVDTLKEYDAFVFGIPTRFGNFPAQWKVFWDQTGGLWASGALYGKPFGLFVSTGTPGGGQESTFMNALSSFIHHGMVYVPLGYGEAFPLLTNLDEVHGGSPWGAGTFAGADGSRQPSDLEKKIHQVQGKNFYAVAKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEC1</accession>
    <name>G3BEC1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_110235</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEC1"/>
    <dbReference type="STRING" id="590646.G3BEC1"/>
    <dbReference type="eggNOG" id="KOG2130">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_1_2_1"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="244"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="514" mass="59513" checksum="ABC18C700CCA1525" modified="2011-11-16" version="1">MIKKTRDPRSIYTRSVMSKHPFGVKPQGNALLEDPRMTYALRKQSLGDLSVLSDDCLMYLLDFIDDIESLKQLMATSKYLFVFTNDEDLWKKRYTSQNKKEQLKWRGSWKRSVLGWNNDIIVNVDLNSEVIYRPFQVANIVYESLFHNLVEAEMNNKKLSINEEGRIPRFAKISQKQFDDIETPFILTDHKWPQWTLEELNSKYGSIKFQQEAVKWPLSTFIEYLQSNKDENPLYLFDCRSEAMTELRKQYQAEIPQVFQEDYFKLLGNHRPDHSWLIVGSKRSGSTFHKDPNNTSAWNACITGKKLWVMLPPHITPPGVSVSEDQSEITSPVGIGEWVLSGFYNDAIKIPEALVGITFPGECMYVPSNWWHLVINLDNSIAITENFVPEKDLQNVLTFFQTRPEQISGFKLNDIKGLINILSCKNQRISEFIQLLEDSSIDLFEDCGELENLPQVPIFDIFKQLLMDNGKEAVLSQILERMKPKRPQKRVWSCISESSTDASPVPFSFNFSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEH2</accession>
    <name>G3BEH2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690400.1">
        <property type="nucleotide sequence ID" value="XM_006690337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEH2"/>
    <dbReference type="STRING" id="590646.G3BEH2"/>
    <dbReference type="GeneID" id="18248373"/>
    <dbReference type="KEGG" id="cten:18248373"/>
    <dbReference type="eggNOG" id="ENOG502SDCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1294268_0_0_1"/>
    <dbReference type="OrthoDB" id="5431245at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="206" mass="23452" checksum="D037F9FFDFDDA82F" modified="2011-11-16" version="1">MSSSTQMSFAQTYVLASKVRGKLTKDASNPKVSLRSLVVQANMLDNLMDHIASENSKRLDKLNRVKFELPKTQRQSDTSSPQYTTSIKEYEVSSDSDSDVELDDYDSDSDDYYYSSEEEEEEEDERSYTAVKVDLSTPMKLGTIQEESEVPGLSISDSEESDDEFDGSHFKASPSVIDHHSLFHNNKLHQHHHHRNDAIYSINEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEH7</accession>
    <name>G3BEH7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Assembly factor for the translocase of the inner membrane complexes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116623</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEH7"/>
    <dbReference type="STRING" id="590646.G3BEH7"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143932_0_0_1"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016694">
        <property type="entry name" value="UCP017292"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF1">
        <property type="entry name" value="HELPER OF TIM PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017292">
        <property type="entry name" value="UCP017292_Znf_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="117" mass="13128" checksum="8503382FA23D368C" modified="2011-11-16" version="1">MPSLESTNGNSIVLLGELMDSHTRCVHYHDPQDIIAIKFRCCETYYPCYQCHESAGHPIEKYDMGSSELVVLCGGCQTELTFAEYSPLVCPTCGGQFNPGCKLHYDIYFTNESRTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEL9</accession>
    <name>G3BEL9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_95392</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEL9"/>
    <dbReference type="GeneID" id="18250499"/>
    <dbReference type="KEGG" id="cten:18250499"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006466_2_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV59925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="768" mass="86835" checksum="99A3D6214A267F5E" modified="2011-11-16" version="1">MMGKRIRKRGVGPFPCSYTSCGKVFSRSDHLRRHMSSHDPTKRLRCRVSTCTKSFTRNDARKVHEKTHIDTPPAIDLLHDLENSTFREETSATQIEAVGQDDDGDDDVPNPHHDIDFSVEKIFFKRRNFFSPDISPSEGNSPFGITSLMSPENQKGVPPKTNSNIGPYFQTSISGFSPDLMGAFEESIDFDFEIPDIFKGPLPFSQNSKDANEQQIDQILLSQMVQYIPDLQEDSNFTLKNMKLFLSNYWSAYHPQFPVLHKPSFSTPDAHPLLLLSMALIGSSLCQSAPAPGYWDLIDSDTIVELSDKIARPLRWLLLSCPEAAPPCKSWLIHSLLILEMYEINRSTRDLHERACIYSATKIQLLRRSPFLGDQNAKSSLENWIENESMRRVAWEAFYVDTIQAVVFNHPANLYANNLKLSLPCPDEFWETDSSDALDLSPSSLIQIPTISESLRKILQNEHVSTGYFGYKIILAGLLNLILQMEQTESQSLVLGLKLSEDNNWQELIASALEYWKLSAPKTSNLCSDKLCQYPEYHAAQTYLRIRQYDYYVYAGSPHRANVKINMKDYESAAKRISRWAQSLNGALTVVQAYILLFEMIVPLNSNSNQQVMVEYEPQKDPVIYRPMAVLATIFPLWCYVFNLYGPESSFKAPDTGLQLEDGFTPSVEDPGSYLRRIREEFGVRTGKPVNSLSSMGSEMVTSTLAEYAKALPEIPKINNIVGLLVLLARGYSKSSSQVAKRFGTLIKHCSDRSMGSNSVFCVELNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEU0</accession>
    <name>G3BEU0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_111973</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEU0"/>
    <dbReference type="STRING" id="590646.G3BEU0"/>
    <dbReference type="GeneID" id="18246332"/>
    <dbReference type="KEGG" id="cten:18246332"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014087_1_0_1"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="505" mass="57988" checksum="8EAFC1EC83618CFB" modified="2011-11-16" version="1">MSRVSFKPMEKTTLWSDKLKQEGKEVPVDLKVYESMIQKDIKFRARNARQMELNKKMTEDLLHDARSYNEIKQLRMNAISLSQKGQFNNSIWGEGYQGYGNGITNVSTQLLLPDGRKLNKRVPESHKTERETNKELLDMLLKTPKRNLVPIRLDIGESENKFKLRDTFLWDLNEKDINIDQFVDVLLDDYKFIDRSVDSFIVKSIKDQIEDYNREPDKAMGELRIPIKINITVNNTQYTDQFEWDILNFEDNDPEEFSVVLCDEMNLPGEFATAISHSIREQTQMFHKSLNLAGYTFDGSPVNEDEIRNHLLPPLRLVSNEGGGFGPLVDDYFSILRNPTNVNDYTPSLIKLTQLEIERLDKEMERETRHKRRQNNELQSLSTGGRGTSRRAAYAPRGGPTLPDLSDIPKTFRTAQPSSVLPGGVDLGVPDIFAYNEVIVHKTNIPNPDYKAPQSKIHRVVFNHDENNGRFLVKIKLGPPPGVNPYQMAPGQYGAMGHLNQTRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEV4</accession>
    <name>G3BEV4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116679</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689815.1">
        <property type="nucleotide sequence ID" value="XM_006689752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEV4"/>
    <dbReference type="STRING" id="590646.G3BEV4"/>
    <dbReference type="GeneID" id="18248400"/>
    <dbReference type="KEGG" id="cten:18248400"/>
    <dbReference type="eggNOG" id="ENOG502S96D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095075_0_0_1"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27070" checksum="391CA9F48DCCEAA2" modified="2011-11-16" version="1">MEEDFHFRLLRISIIQLLKSHGFDKSKSSTADVVTDLYVNMLDLLVTKAVRFSNLRNDDMKAIDILQAMLEVGLLKNSDNTKYNTKSVDSFKNWLSSLTFNTSKQVNQVPGNLKKVIIENRNFKDEMNDEEEKLRRLKKKQDFFNSFGQADDNTHADGMGAFDDDEVNIDINWVDYLIEKDSKFSNKKFEDTSLGPTVSTGNGVAGDYLVEASTDHVNQFLPINIKYDDRFEDEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEV5</accession>
    <name>G3BEV5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_128002</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEV5"/>
    <dbReference type="eggNOG" id="ENOG502SRSS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4093447at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="514" mass="56427" checksum="529C487F964A4411" modified="2011-11-16" version="1">MMMNKNNNLSLKINNPLSISDNGPYTPLDQTLRTPIDPPNQNYFGQNFPNNLPQHPPHPQSQPPHQQQIYSNPIYNDSDDILTDTDDVNGSGIKTAKNYSLNFTSNFDYLVMSVYSHILSLPTTTPFSGTIPPSGLVGRVANETMNNLVSSISVNSGASYDQHSIINKDMLSNNSYRPIFLSLIRKRLIELCSHKNSSSKLPLSTSISINSMQNSNATGNNPYYSGNANIYASNARQSSISNLSLTELNINHYQEQQQAAAQQGKSRSSSINLRKQSLTRNNSYNSTTTSNWLHVGNLSTIRHPNESTDSLQSMQDYVPQPFINRSANGTSNSPNGNSALGNMSTPTGSAFSFNNMMMDYQTPPGSNTGSNKSSFSTPPGAPLHNIQIVQNPVSTSTTAPVPNLQEYDEFNFGSRSRSSSNPRLNGFPRPLTINTDNANLQALNSLNGNTETLDSPFMSATTPSDDFSLMQNAFINGSIPQSPIAEEREERILPTKLSLSEKKRDSLRLKRGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEV8</accession>
    <name>G3BEV8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_96055</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEV8"/>
    <dbReference type="STRING" id="590646.G3BEV8"/>
    <dbReference type="GeneID" id="18250574"/>
    <dbReference type="KEGG" id="cten:18250574"/>
    <dbReference type="eggNOG" id="KOG0562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066882_3_1_1"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="2">
        <location>
            <begin position="143"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="249" mass="28821" checksum="C26CB032A918857D" modified="2011-11-16" version="1">MSFADAFQTYINNPEICKKITLYNDDTVIIIKDMFPKSLRHYLVIPKSPAVTHAHPLKVFNDNVKLYDILEDYVQLTKQYITDDLVKFGLLEDDPETIKQFKQTFIQCGVHSIPSLNNLHIHVMTRDFNSPRLKHKKHFNSFNTRFFVDFEDLNPIGENNNTEYSDSNSENLPDTEYSSGSDDSRTEISNYKFEMNPKKLHDLVKSTPLKCCYCGQSFGNSFSQLKKHLTVEFAKKFDTSKDITCNGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF22</accession>
    <name>G3BF22_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_126721</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689205.1">
        <property type="nucleotide sequence ID" value="XM_006689142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF22"/>
    <dbReference type="STRING" id="590646.G3BF22"/>
    <dbReference type="GeneID" id="18249191"/>
    <dbReference type="KEGG" id="cten:18249191"/>
    <dbReference type="eggNOG" id="ENOG502QT80">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016397_0_1_1"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="271"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="8">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV59991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="540" mass="61211" checksum="49BABA4F8AC0F241" modified="2011-11-16" version="1">MAPKPKEQPEAPDTSVDHESVNPSAAEVTASFSSTQSHAVDAKPQSSPLLSSTPPIVSKALVRAYPYLLIVNKLLSIITWTNDDYWVNVVLISAYALVVLYFEALVTWFGHLLIVGFITLYALLNKKILQEANLHPSLDEVIQALTNTCLKADRLLDPIISLSLTAYDIKRLLFTTVFLTPIYLIVSFLLIQPRTILLVTGVYLLTYHSAYSSVTRKMIWKLRLTRVLFFYLTGLDFSRQRNHSLFAAAFAKVQKNAGHSLNPLSSKSNRPVRFTYVIYENQRRWLGIGWTSNLLSYERTPWTDEFLNESSSIDSFKLPNPENHQQYSFGSEQSSQLSMNNARWRWVDKSWRLDLTNDGAVTLPPGKRSKTTANPGSDEGFIYYDNTWKRPTTDDSYSKYTRRRRWIRTAELVFDNDNDDDDISTYDPADEDTPKVKKNLRFAEPVPETDEEKEESRPSDLIDMEDIKSSKQQTDTVSSILEKLEVAPQSITKEVLTPVLTTDLDTSTSDIEDIKSVNPVSDPGTIFSPGNPPVDDKKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF29</accession>
    <name>G3BF29_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_128016</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF29"/>
    <dbReference type="STRING" id="590646.G3BF29"/>
    <dbReference type="eggNOG" id="KOG1126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008850_2_0_1"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="552" mass="64453" checksum="5B7C5D09A9932CF1" modified="2011-11-16" version="1">MQEQPFVIQHLRSIIIHSLDTFNYTNAEFAGERLLAQDPEDLDSIYLYCLVLFHQKKYKTCYNRLINLEDHLGCSYLFGKSCLHLKKYKEGVYQLMKVNYLYNDSTLKPHQTSGFDVHHFSSSFNRFNYESNRNVLPDASGVYHLLGDLYNKTGDIKNSSLNYSYCLKFNQFDFEAFQNDKERLRSSLKRNNSNSNIHSNGESSGLVSEPGTIKSVFTSKEIESSESFLLQLYVVLARSYKCFSKYDCYKAIRILESLPEAEKNSPWVLSKLGRLHYEIVNYKQSEAFFVKLRMMDRTRLEDMEYYSTLLWHLHKKIELTYLANELFDLDSKNAITWCVIGNLFSLNREPDEAIKCFTKAVKFDENFSYAYTLKGHEYFGNDNYEMALENFRISLVIDPRHYNALYGIGMVYINLGDYQKADYHFRRAVSINPINIILICCVGMVLEKMGKKNLALRQYELANKLQPLNPLPIFKKAQLLFTMQQFQQSLQLFEVLKDLAPDEASVHFLLGQLYNIQDNKHQAIKEFTIALNLDPKGNYLIREAMESLQEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF30</accession>
    <name>G3BF30_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_110996</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689832.1">
        <property type="nucleotide sequence ID" value="XM_006689769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF30"/>
    <dbReference type="GeneID" id="18246240"/>
    <dbReference type="KEGG" id="cten:18246240"/>
    <dbReference type="eggNOG" id="KOG1278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010714_4_0_1"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007361661" description="Transmembrane 9 superfamily member" evidence="9">
        <location>
            <begin position="21"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="675" mass="75825" checksum="477788A7BEA3EFB5" modified="2011-11-16" version="1">MKSWTCLFVVVFSLFVEVSSFNFGLDLGLSPKYYKKGQKVDLLVNKVESDHTQLPFGYFDLNFVCPASREKKPLHISLGEILRGDRLWESDFKLAFGKDISCARLCDFLAKVPQITFADRLIKQGYVVHWSIDGLPGATTFVSNNKNSKYYAAGFPLGFFEDDISYLYNHFMLVIRYHSEKKHPGMHTIVGFEVYPKSVVDETCPGSSKSYENLALKLPEGKKGKVAKLRIPYTYSVYWREDNSIDYANRWELYYANETHSASTKIHWLSFLNSVVLVSLLTLVVVIILVRINRLDSKNSDSSPNLALTAEIDNAFSKNAAWKNLGGAVTKRPVFPLLLSMLVSSGLQLIIATVGIILSVIIKSQLDYNKARGGEFSNYQGAFSSLALSCFVMSGILPSFFGFVLYKIFNNENLSVQIPPAKAVKLSILFSGFLPCLVLSVMLFFNFFVFAKESSNALPFGSIVILLILFFLIVLPLGLIGGYYGNKLKFNKKSIMFFSEKGKDSPNFVPQVNVSTTAKRALMSVIRNSTIVMLIYGLIPFGIVYVELSFIFNSIWLEKTTFYYMYGFLFLTTLSLIIIVSESTIIGIYISLVIENNPNWQWLSFRIGSSIGLYIYAYSIYYFFSLLNVQDFVSILLYFGYMALVSVLIGIAGGSVAVLTGMVFIKKLLTSTKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF71</accession>
    <name>G3BF71_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTEDRAFT_100025</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF71"/>
    <dbReference type="STRING" id="590646.G3BF71"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_2_2_1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442907" description="Crh-like protein" evidence="20">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="21">
        <location>
            <begin position="42"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="271"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="290"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="26"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EGV60655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="421" mass="44837" checksum="32CE0ED37A7AD44B" modified="2011-11-16" version="1">MIGFTKCLVLLIHTIAISATSTSSLCNPLSTSSCPSEKALATDVAYQFTSESDDFEVTSIPSGISYSDNGVTMTIAKRYDNPTLMSKFYIMFGRVEVSMKAGNGTGIVSSFYLQSNDLDEIDIELIGGDSTQWQSNYFVKGDTTTYDRGEFHDTSAPPQNDYHNYTIDWTNEKIVWYYDGSAVRTLKNDSSQGFPQSPMYLKFGIWAGGDPSNEAGTIEWAGGETDYSQVPFSMHINHLEVSDYSTGDSYSYTDQSGDWSSIEADNGKVLGRQNSANLNPSVGDTEDSDSTSSTASKTSSQSASKTSKATSTKTSSKSSTEVSSTEMSFTEVSSKVSSEEASSTDSQSSAEISTVVSESLATDSETLSDSSRSSGSGSSSSSSSRSSSAVQTLASTESTDSSSSSTTPCIALMAIIASFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFE1</accession>
    <name>G3BFE1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA binding transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_111455</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFE1"/>
    <dbReference type="STRING" id="590646.G3BFE1"/>
    <dbReference type="GeneID" id="18246282"/>
    <dbReference type="KEGG" id="cten:18246282"/>
    <dbReference type="eggNOG" id="ENOG502RY09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032654_0_0_1"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="29"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="29"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV60664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="305" mass="34857" checksum="33D9C9E06B6CCB38" modified="2011-11-16" version="1" fragment="single">MRRKSKRSLTVKQRKKQVVKARDKNSKKEQVSLNSPEDLKNDCSEVTNTNPNKRKVAPRSSDQFKVGPDFDDTEVHRKCFISSTKEHIVPVISARIDRGFDLINNEWVGYKRNYFTLVSTFEFLDQPGDLCSNTKFHICDDEGKEVNIECFAIRLVSECCENDVGVVLVQHTPKRDRGPQYLPPVFVSVPGVLPEHEVIKSSANIRNGVKMSQLDRLFYLEENKLKQAKEGSILKGYPKGKVCTVAKYERMQFSTTLNYRKPALLNRRFVLRVELLAVLADEKYSVLASSETPPLIVRGRSPSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFK6</accession>
    <name>G3BFK6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plasma membrane proteolipid 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116067</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFK6"/>
    <dbReference type="eggNOG" id="KOG1773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107649_7_2_1"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="55" mass="6155" checksum="C4209680BC5E4E87" modified="2011-11-16" version="1">MDSEKIVACIIAVFLPPLAVFMKVGATSPLWVNLVCCIFFWFPAILHALYVVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFP9</accession>
    <name>G3BFP9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_95541</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689289.1">
        <property type="nucleotide sequence ID" value="XM_006689226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFP9"/>
    <dbReference type="STRING" id="590646.G3BFP9"/>
    <dbReference type="GeneID" id="18250512"/>
    <dbReference type="KEGG" id="cten:18250512"/>
    <dbReference type="eggNOG" id="ENOG502RQ5Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_702073_0_0_1"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442864" evidence="2">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="393" mass="42160" checksum="C483B1A769E02CE5" modified="2011-11-16" version="1">MKLSTLALSCFSLFTCIHGETSSPSFVEYGVDVVERQLSIPSLVSSLLDGFDVADIISDVNFEKIAGWADDLLNEGDNIDILDKIFVSLKNTKILPNAGVYLVTHNSTLQILEDSLPTILSVTGNINTTDFWVALDRSGLAYSVVAGALESDEFLPSVLSIAKKLIKSGGINLESLLEQAEKLIERDTIYAEFESEVEPPMTFATLYRRDNIEDLLETVMESIERSGLLNDTIMTLLTDEEFQDATVVLIQGALQNIGSLIQGSDFSALSPILQSLWDSNMLQDILEEALQDKGLRTALTTDLASMLKQGSIKETDLVSKSDKAAILAKDEAMSASEVESSVAAASATEASSSSKASSSSTETSDSEDGASLFRSSPAAVALGVLVPVGMFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AVZ6</accession>
    <name>G3AVZ6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_112143</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AVZ6"/>
    <dbReference type="STRING" id="590646.G3AVZ6"/>
    <dbReference type="eggNOG" id="KOG3424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_1_0_1"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="135" mass="15303" checksum="5DB515EFA3440CE2" modified="2011-11-16" version="1">MSDAVTIRTRKVISNPLLARRQFVIDVLHPNRANVSKDELREKLAEIYKAEKDSVSVFGFRTQFGGGKSTGFGLIYQSVADAKKFEPAYRLVRAGLADKVEKPSRQQRRQKKNRDKKIFGTHKKAAKKAAKRNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWJ5</accession>
    <name>G3AWJ5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_117566</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWJ5"/>
    <dbReference type="STRING" id="590646.G3AWJ5"/>
    <dbReference type="eggNOG" id="KOG2612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130538_0_0_1"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="88" mass="10174" checksum="09186B60077C0D2A" modified="2011-11-16" version="1">MMFNLIKHETLDKLALYKAKTASVDSEGSRIEVLIKEHNVNLDIFNQDKVKLKTADTNKYFTCENCGRSISGGRFAQHINKCLERKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWN4</accession>
    <name>G3AWN4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="7 19">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_96599</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="19">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 19">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="7 19"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWN4"/>
    <dbReference type="STRING" id="590646.G3AWN4"/>
    <dbReference type="GeneID" id="18250617"/>
    <dbReference type="KEGG" id="cten:18250617"/>
    <dbReference type="eggNOG" id="KOG0786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16 19" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 19" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 19" id="KW-0520">NAD</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="20">
        <location>
            <begin position="12"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV66577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="377" mass="40531" checksum="6B0D3FAEEB438A01" modified="2011-11-16" version="1">MSKAELSLETKTITLLPGDHVGEEVVAEAVKVLKAIERSTPKNIQFNFEKHLIGGAAIDATGVPLPDESLEASKRSDAVLLGAVGGPKWGTGKVRPEQGLLEIRKELNLYANLRPCNFVSDKLLELSPLKAEVVKGTNFCVVRELVGGIYFGERQEQEDSADGTSAWDTEKYTVAEVTRITRMAAFMALQHNPPLPIWSLDKANVLASSRLWRKTVDDVISKEFPQLTLQHQLIDSAAMILVQSPKKLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNKAFGLYEPCHGSAPDLPVNKVNPVATILSVAMMLRLSLDCLAEAEALETAVGNVIDRGIRTADLRGQSTTQEVGDAIAEEVEKILGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX36</accession>
    <name>G3AX36_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112421</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX36"/>
    <dbReference type="STRING" id="590646.G3AX36"/>
    <dbReference type="MEROPS" id="C12.002"/>
    <dbReference type="GeneID" id="18246513"/>
    <dbReference type="KEGG" id="cten:18246513"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="241" mass="26949" checksum="B10211FE2E300488" modified="2011-11-16" version="1">MPDSKRVIPLESNPDIFTAMAHKLGLSPVLEFHDVLSLTEPDLVAFLPQPVFGVTLLFPITKEYEDYRTRFDSTRAPYSSESIDTVRWFKQTIGNGCGLYALLHLITNLQSDLIIDNSLLNSFLIQQLNRSLSTEDIAKLVENLEQQIQLDENYGSGGQTEAPPPEISVELHFITFVKGKDNHLYELDGRRTGPVDLGESVGGSNIIEDPKLNEKIQFYISNTNEANKHNFAMIALGPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX66</accession>
    <name>G3AX66_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_101074</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="16">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex. Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore. DASH complex oligomerization strengthens microtubule attachments. On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX66"/>
    <dbReference type="STRING" id="590646.G3AX66"/>
    <dbReference type="GeneID" id="18245435"/>
    <dbReference type="KEGG" id="cten:18245435"/>
    <dbReference type="eggNOG" id="ENOG502SDEQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112993_1_0_1"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="14" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="81"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV66700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="169" mass="19515" checksum="2D3BB61C88EE2AB0" modified="2011-11-16" version="1">MPQTPSANTNEYLLSCVSSLRASTQLLDKSIKVVDASTKDVHRLNKILKTDNVFGLVAESDLQHSIKTVQDELEPKVDALKHKYEQEVEKVRNRTNNLKNKIELQRVRLQTIRNSKGSHDVMNDKLLRLNFLRNKKSRLKFNLSRYQLEDQKNRLSAASTPQPMEEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXC1</accession>
    <name>G3AXC1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S64</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_91506</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXC1"/>
    <dbReference type="STRING" id="590646.G3AXC1"/>
    <dbReference type="MEROPS" id="S64.001"/>
    <dbReference type="GeneID" id="18250079"/>
    <dbReference type="KEGG" id="cten:18250079"/>
    <dbReference type="eggNOG" id="ENOG502QR0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012881_0_0_1"/>
    <dbReference type="OrthoDB" id="4096087at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012985">
        <property type="entry name" value="Peptidase_S64_Ssy5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08192">
        <property type="entry name" value="Peptidase_S64"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="799" mass="88960" checksum="991A7440C43D68D9" modified="2011-11-16" version="1">MSMKKFLGRHRKAGEHEDILSETSNLSAPGTHANRQSVSTTGSGDSIDEIEMFDDNTMQNDPNLNLNPSISNTPTTNRLNPSIFTRNSSKNDKSIFSSGKRTMSTNQSSHYSSQSQASKSSLSKALDYGQRLQILEVQEELHQDNPVEVISERLHQLGEDMSFAMNQYNNSISNLTSAVINNIDLLKNFTSFIKDLNEVTSEVSWKFTTYNNSHLRKIMKIYLNLYDNLLQDEVFIKLKLLLVKNFNEFATTLNTSNRRASVQNPTVITKPQNYAIGCNNKESLPNEDVIVNIINRIAATPIKIKEQNGSFIAPIVRGIAKDMNILTLYFGYPNPTDYHSKLTQSLHDLYDDIHVIVVKNFIELASTKSAPASNSANLGATTSPVPQAPVQMFKLPFRVPTDVKTPPMSLSISIENASRTSGTVGGFIYPMIDLAKQPHLESYSNSKFAISCGHVCLNNSDDETEYPHVSAPSSVLISLYKKALTQQYEKLSRSGNDATMMEAKVAYASVLKQVDQMFPMKKIKLKNSKSKQGYYETRNLPAYGFGQIIWGERTLMAMKNSNEKRLSDLAIIKVNKNLTCDQNFLGDDIAFNEFDPGLMFDNLYVRRVIDLTRPTKEEENELDLDIDEVDDEAPAPRNNNAGLPVFKYGSTTKFTQGNLNGIKLVYWLDGAIHSSEFVVNSIDNNSAFAAGGDSGSWLLSKLEDCDTISESKGLGVLGMLHSYDGEFKQFGLFTPMVEILSRLEEVTKIRWGVVGVPEKDDSKNAPEVDTESEIVSVSSFDESDESDEEFGGANPPEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXI2</accession>
    <name>G3AXI2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_100277</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXI2"/>
    <dbReference type="GeneID" id="18245373"/>
    <dbReference type="KEGG" id="cten:18245373"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006466_2_0_1"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="703" mass="80085" checksum="475013D1FD67ECAC" modified="2011-11-16" version="1">MSKLFVCEYPDCSKSFSRKDHLKRHNLNHNNSFPHECSICLMKFKRADVKHEHYAKHFQPNGFKRKSRTKVNTVTTPSPPISESSALNWLFEESSFENNQIQLINSTIFDNQANSMLMELLGSNLDQFPSVLINFSAVSPELLALYVDAIPQLVQHPDFISSSLEYCLTVYWEIFHVQFPILHKPSFNTLAVSPLLTLSMIMMGAVLSYSSQTASPLIDASGLSLLIGSELRWLIFRHRRPNKSDPWELQSLLILEVYEKHYANRDLHERSSIHQAAKIEMMKRSTLLGGDPYSSESMSSAELKQAQNEVLLAKWVAAESMKRCLLMSFVFDLTSSIISSHCSSLFVDKLKLSLPCDDIIWEADLSTLKNIALPQKPPSIRSCFNKLLQGEKIEASSFGNKVLFHAITSLIIQLEQRDDTLSLINGLKPDILNDNWRLKISFALDSWKFNINQGSCCNIDSLLIDLRVRNKPTTKYFELNEPRCKMPVYHMAHIRLHIINHDLLIYAGVPARMNVVANKQDYDNVAERMVKWANSVNGRMGVIHAYLCLFECLLPVDQGDIDYKPATDPIPERPHVIVDSCLTIWGYNFVLWGPESDRYNSGELAFKESGSEYLSRMKSILGTALAENNAQDFYLSVKRLAKSLLTVPNTRNLAGFMNEMSRIYSQCFWTLGQEYSRLFASCAERSMGRGEVFCANMYKESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXJ4</accession>
    <name>G3AXJ4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_96454</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXJ4"/>
    <dbReference type="STRING" id="590646.G3AXJ4"/>
    <dbReference type="GeneID" id="18250610"/>
    <dbReference type="KEGG" id="cten:18250610"/>
    <dbReference type="eggNOG" id="KOG4123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022957_2_0_1"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="541" mass="62228" checksum="76C10A3048E0BA37" modified="2011-11-16" version="1">MSSGVSWRQVYIVTIILRFILGISDSYIHPDEHFQNFEVLASKFFGFSTTIPWEFESDLPARSFGPLYLFYGPLFAFIKFFGVKVTPKAVWYMARLQLIFVNWLVTDMCLYRLLPTKPERVKAVFFTSTSYITLVLQSHCFSNSLETPLVLISLLIISDLRFDSEVRDVTVCSYDKLFYFGIAIAIGIFNRVTFPAFLVIPSYFLLKYIWKFKIGLLVGILGFMIPTTLFIFIDTYEFKHIVLVSSPRELVITPLNNLIYNSSYKNLALHGIHPFYTHVLINLPQVFGPLLCVLFYKGRNNYYRTVPFLSFVSGLTILSFVPHQELRFLMPLLPIASCCIDFSRIMGVDTESEEIKEKIISNENNLKPDKVLTRSSNFATSIIVLWYLFNIVMCLLMGILHQGGVIPALDYSHANLVLQNEKFVQIWWRTYSPPTWLLGSPKYSTIMVTLEQFNTSLLKKYDNLIIDAMGSDQKDIYDIIKGVQSTNKKLMLVAPVASINCDFESSSLQMIWKYSYHLDLDHLNFESLECLAPGLGIYEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXN7</accession>
    <name>G3AXN7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_112531</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXN7"/>
    <dbReference type="STRING" id="590646.G3AXN7"/>
    <dbReference type="GeneID" id="18246563"/>
    <dbReference type="KEGG" id="cten:18246563"/>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_1"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030312">
        <property type="term" value="C:external encapsulating structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="331" mass="35597" checksum="9847E399C48AF28C" modified="2011-11-16" version="1">MKIGINGFGRIGRLVLRIAIARPDIEVVAINDPFIAADYAAYMFKYDSTHGRFKGEVTSEDNTLVINGHVIKVYQERDPVNIPWGKDKVEYVIDSTGVFTKLAGAQKHLDAGAKKVLITAPSADAPMFVVGVNEDKYTPDLNIISNASCTTNCLAPLAKVINDKFGIKDGLMTTIHSITATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVIPELNGKLTGLSMRVPTTDVSVVDLTVNLATTTTYEEICATVKAAAEGPLKGVLGYTEESVVSSDFVTSHESSVFDAKAGIMLTPTFVKLIAWYDNEYGYSTRVVDLLEYVAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXY7</accession>
    <name>G3AXY7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_112589</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXY7"/>
    <dbReference type="STRING" id="590646.G3AXY7"/>
    <dbReference type="GeneID" id="18246596"/>
    <dbReference type="KEGG" id="cten:18246596"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044236_0_0_1"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="375" mass="43007" checksum="3EB20EDA81EAA835" modified="2011-11-16" version="1">MIARSLSADEYEALNGEERLREQVEDLVLSNTDEDDDDDEEIDTVANEANEPLPVEYRGTIIPDPDVQQIEADNVLTDSYEDDTDYLELIHLKIGSLSDLDLGRFTKLESVCFRQNLITSMVDVRDLSDTVEELDFYDNRINHISSNIGKLVNLKNLDLSFNKIKNIKNLEKLTELENLYFVQNKIKEIKNLDNNLKIKNLELGGNKIGDISEMMLKLVNIEQLWLGKNQIPRLQNLQNLKNLRILSIQSNRIEKIEGLESLENLQELYLSHNKISKIENLEHNTKLQVLDVTSNGLKSLSGLSHLKQLTDFWCSYNQISNFNEINRELGSLPELDTVYFEGNPVQTSNPTAYRRKLRLSLGPSLSKIDATYVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY15</accession>
    <name>G3AY15_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_112607</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY15"/>
    <dbReference type="STRING" id="590646.G3AY15"/>
    <dbReference type="GeneID" id="18246602"/>
    <dbReference type="KEGG" id="cten:18246602"/>
    <dbReference type="eggNOG" id="KOG3296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042174_0_0_1"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="386" mass="42092" checksum="54427DB7FE15CEC4" modified="2011-11-16" version="1">MSEQTSTIPTSFGDLNKGVSTLPSNTVQETTGPLNPFYQYINDVYTTIGEHRKSLGLVNPGTIENINKEVSRDVFLNQYFFTGLRADLNKAFSMFPVFQTSHTLSMGSQVLPAYAFSALYYGEKTFMQGNIDNDLSFSGRINYGWNANNVSKLTLQLANGQPAMVQLEQDYQAGDFSVNFKTLNPSFLNDGFTGLAVASLLQSLSKKLSVGVESSYTKQPGAPVPESAISYYARYNNGNWIFSGQLLAQGALIASFWRKVTDKVEAGVETQVSATMRPITDNFSGTPIGMEPVIEGQTTVGAKYEYRQSVYRGQIDSTGKVGVFMEKRVLPTIALLFSGEIDHAKNNSRIGVGLQFESAGNEQIMMMQQGLVDANGNPVPGAPQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYA1</accession>
    <name>G3AYA1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_112669</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYA1"/>
    <dbReference type="STRING" id="590646.G3AYA1"/>
    <dbReference type="GeneID" id="18246628"/>
    <dbReference type="KEGG" id="cten:18246628"/>
    <dbReference type="eggNOG" id="KOG0016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_6_2_1"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="274" mass="30769" checksum="267DBF7C3A246385" modified="2011-11-16" version="1">MAEDIIYEVRDRTVVITLNIPDKLNSLNGEQYMKLARAVEDADNEEGTVVTIIQSTGRFFSAGANFSDKGISQAKTEDLFSHDYWLNKFVARNTYITNVFHNHKKVLVAAVNGPVIGLSAALVALCDLIYVKDDTQFYILCPFSNLGLVCEGATSATLFMRLGWSKASEALLFARPIQGPELTRLGFVNKAYNDYKFASTEEFNAQIYKDVVAQFENLHEASIFLNKELLKVNREPAIHAANSKEVVMGLYKWVEGVPQSRFVQLAQKDIKHKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ12</accession>
    <name>G3AZ12_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">CANTEDRAFT_112855</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684844.1">
        <property type="nucleotide sequence ID" value="XM_006684781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ12"/>
    <dbReference type="STRING" id="590646.G3AZ12"/>
    <dbReference type="GeneID" id="18246706"/>
    <dbReference type="KEGG" id="cten:18246706"/>
    <dbReference type="eggNOG" id="KOG0645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_8_1"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="401" mass="45078" checksum="B78D552C2617BE30" modified="2011-11-16" version="1">MVHLIKSIEAHRDKVWSVSGHANLPLLATSSTDQTCNLYKLSCRKNFPLISKLQDAHKRSVRSVAFKPPLGGADTPDTDYIDLPALAAGSFDSTISVWGIDEPEDQFEDDEYENDADKHDKQVQILTSPQNDWNLMAIIEGHENEIKAVAWNYKGNLLASCSRDKTIWIWETDPETLEEFECISVLSDHDQDIKNVTWHPTQNILASSSYDDTIRLYKQDENDDDWSCVGVLNGHDGTVWCSAFEHPKAPSSSEGKVRLVSASDDLSVRIWSCKETVNNEEDYERNSALPSSIKYVAKEMTWELELVLPSVHEYPVYSVCWSKESGKIASAGSDGKIAIYKQNENSNDWEIESQYSSAHGVSEINCISWCKLEEGDEVLVTAGDDGHVNIWDPSIAKREDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ87</accession>
    <name>G3AZ87_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF431-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_97097</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ87"/>
    <dbReference type="STRING" id="590646.G3AZ87"/>
    <dbReference type="GeneID" id="18250655"/>
    <dbReference type="KEGG" id="cten:18250655"/>
    <dbReference type="eggNOG" id="ENOG502RXXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080487_0_0_1"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="203" mass="23543" checksum="53843E22E78E6582" modified="2011-11-16" version="1">MKYIIEHMEPEFSEWVVLEYTQIIKDVGKENLVLTSLPANTTEKDIPQQLLDLGLQWTTQECIQIDNGLDHSRVCLLDPAAETDLVPNDQQKFDYFVFGGILGSHPRIDRTGLLRDKYGFSGRRLGELQMTTDTAVRTTQRIVDKQVKFEDIKFIDYPEIKFNRYESTEMPFRYILDDTNTPILPKGMLKLIENDCDKGIDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZD6</accession>
    <name>G3AZD6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">CANTEDRAFT_133500</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZD6"/>
    <dbReference type="STRING" id="590646.G3AZD6"/>
    <dbReference type="GeneID" id="18249712"/>
    <dbReference type="KEGG" id="cten:18249712"/>
    <dbReference type="eggNOG" id="ENOG502QS9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023188_1_0_1"/>
    <dbReference type="OrthoDB" id="5319830at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="577" mass="66074" checksum="E8B5A1EDD48B5D33" modified="2011-11-16" version="1">MSNHHIIQVKVEDELFNGSKDPFLHNEDDFSVEEIIPKILLERKSFLSLTEEGLQKESEGLSFGIDAVDTEDATETSPSDGGEETKENDSSELDQIHDIKMNLSKNINLALNETSLALDLVSLLLSATKPSLAKSTISPHLAKNVPLGSFSSDRLTPEENAPKNDVNVNKIGQGWKYESLSKIKSLFSNKREELQLQGQKEKVYWNQINKVLSNNEILLKMRDPADKSKSIGVKYGYGDSGSSYHDKGIAILRRNPKTGELTFAPVLESNNKLINKTFKYVKVKILSKVDDEYTLTGQSKFEFNFKDDSAGRLITDIEKARFFIFEEDLFFQLTREARTLINYNVSIIADKIIIEVNNEIIEIETISYDETSEDDTDRLYLAANEQSSQNDLKCQLILNYLKIMLCGYFKYNLNLKQKIPTSFTKFKQNNSHPLILRPLIGHFKHEAYVDKLSTLMAEAMEKYKHKLEFEFIVSKYENIKNLTKIETPFIKSIEKPISRFNLIIKNPVNKKCLKVDVDLTTSEIFVNLILHLKIIRYEKVENLNLNEKGTNVLKLTFSDFTEVDQSVDWSIQKFLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZR1</accession>
    <name>G3AZR1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_133530</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZR1"/>
    <dbReference type="STRING" id="590646.G3AZR1"/>
    <dbReference type="eggNOG" id="KOG2938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_7_0_1"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF25">
        <property type="entry name" value="INOSINE_URIDINE-PREFERRING NUCLEOSIDE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="52"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="393" mass="43328" checksum="7E7336B57DD42BAC" modified="2011-11-16" version="1">MPYFSKASMRSIFPPTDIPWFFFPKTLLVLATALSATAKKVFIDNDEANTPTILIPLFAGWEILGVSGSFGSSSYVDSVGSHATILENYSLDSCVPLYGGASKPFLRTNETFHVWEQLYGTLVWEGAWSPYYTDSYTWKDFSYNETLPGAIAMIEAVKAYKDSDPVTIFAAGTMTTVAQAISIYPNLVKEAAGLYIMGGYIDVQYAHAAGSSFQDDLVSDINIIQDPEAAQMVLTADWKKIIIGGNVTNAETPSQDLYDEMIERAGGLEEIQESPYLVGVNETVLSGNYTLNSVSTENILPFWDSVVSAFMVSPEIITHKTSVALAVDTSFNSPFYGTVRIWSHDRAPTAYKTGNVTIVDSIDQDKFYDILVDAYFQNYTNYCTGGNLTELDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZT5</accession>
    <name>G3AZT5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_133544</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZT5"/>
    <dbReference type="STRING" id="590646.G3AZT5"/>
    <dbReference type="GeneID" id="18249719"/>
    <dbReference type="KEGG" id="cten:18249719"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001645_11_1_1"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="398"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="560"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="675" mass="75528" checksum="6B0ED68FD91D0119" modified="2011-11-16" version="1">MSPPHTASSRGPRPINMNMDNLNIPTFTFGSVSPASSTSTTASSTISNPFSTTTDQAPGYISPSVSLNISTSMPKSPSMKSPISMKSPTHLHSPHDLPIQKAHAGELEQFVTSHKPVIIDIRSFNHYMNFKISGSVNVCIPSTLLKRSSYKLPNILSSFKLSQETQEKLLSGSTNVLFIDTNSNDMLSYPLYQTIQKFVAHNKDLHLWYLFGGIESINKNSSMVEVESPVASPNDYKGEDSGSFATCCAAGPPTSLSGFQLPSSTPSNQKFLSSLKKNVPKLDIKSIIESEDLKGYNYTFKVPSSSKNLKNLPLWFKTILLDDRGEVNSNSKILKHLNAKFNKIEKVEQIRLNLAITDTTSNKADLENHTSFCSASTPCPQCDDINYKIPKGVEYGFKNRYNNVWPYEHSRVRLDHSPHPGATEATEGNEASFFEGVSFDDYFNGNYINYSKISDNSYIATQNPLPSTFKDFWKLIWSKKTKLIICLNTQSSLQPSYFNTQILDNFSVKEVEVKEYGTFIMKVIEVTKTLADHSAEMLTVHHLEFINWPDFGVPDIDTLIGFINFKNKLIETQNLGNGCLVHCSAGCGRTGCFIAIDSIIHLLKNYDGDSSQYPSATNYSNKENDSIKFDPFGDVDLVYKSIQFQRTQRISMCQNFDQFIVCYESVLKYLLDFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B071</accession>
    <name>G3B071_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_119582</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685019.1">
        <property type="nucleotide sequence ID" value="XM_006684956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B071"/>
    <dbReference type="GeneID" id="18248712"/>
    <dbReference type="KEGG" id="cten:18248712"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_5_1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010509">
        <property type="term" value="P:intracellular polyamine homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="122"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="649" mass="70851" checksum="8AC23D8887E7DF12" modified="2011-11-16" version="1">MIQPHTQTGSPPPPDPPDDNGTSINPSPRRPSHSLSSLESINSNASSSHPPPQTIDQKVQKTTNSIAGPADEKPPLNHAPSNTSAKSNRVPLGQRRGLLAQITLIPEYEDPRDYGPRQKMVIVLIVALAAICGPMGTSILLPAIEDVGKDLHTSTSVVNVSVGIYLLAMGIFPLWWSAFSEKHGRRNVYLVSFTMFVGFCVGCSLAPSIQTLIVFRVLCGGCSASVQSVGAGTIGDLYVPSERGRAMGWYYLGPLMGPFLSPILGGAVAQAWGWRATQWVLVIVSGLSLMGILFLLPETLRKQDDMANIRKLLASAMQEHSDSEKSSGGGDNEEMMLDLVQSVVRSVRSEHEQQDDQDEFLGEPAGDSIMPSLSRLTTNRSAYSVRINMETLQHELSKSMSRKSVHTTKWQSFKHEAYEYMIRPMHSLVLLGYPPVLLVICYSSISFSLVYFFNLTISYAYSKSPYNFSSVIVGLLYIPNSVTYVIASILGGRWNDRLLRQYAAAHNGEIRPEARISWNLVTAVLLFPPACLIFGWTLDKGLIWVVSLIGTAIFGFAAMLVIGATVTCLVDTLPGKGATGVALNNLIRQILAAVASFIVEPLLRALGPGVLYSILTGIIIVASGVLVYLKRNGDRFRERYDLSTFYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B079</accession>
    <name>G3B079_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_113056</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B079"/>
    <dbReference type="STRING" id="590646.G3B079"/>
    <dbReference type="GeneID" id="18246805"/>
    <dbReference type="KEGG" id="cten:18246805"/>
    <dbReference type="eggNOG" id="KOG2199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010104_2_0_1"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="221"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="389"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="451"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV65341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="483" mass="54121" checksum="A04B5422E3647981" modified="2011-11-16" version="1">MSELEKLINKATDPTLTSDNWQYILDVCDNISTNPEEQTKQAIRIITLRLNTKDANVMLRTLALITAVAENCGSRMKQEIATKSFLYDCLIKKLSDRKIHKTIKISVAQVIGQLHESFKSDPSLKPMTDAYNTVASDYKQFLSQKPDTFGPSKPAKQEMSQSDKVKEDEDLQRVLKLSLQEYEREKAVRKAYLNDKPLPVTRTEAAPQQLQPQNSAEQTIATVSKVRALYDLISYEPDELSFRKGDIISVIESVYRDWWRGSLPNGKVGIFPLNYVTPIVSKSAQELESESAWEDNILSNESRKIDRLLGLLSTNSPDLNEDEITDLYNQILPLRPALANSIEKYSSRKEELTSLNGQLNVQIKFFNELVDNSINQRINHQYSGAPATSMPYPSFPQFLPQNPSSDQGYIAQQPTSSGFGNAPRPAQATGSVPQTYPSYPQYGAAPEAINVQPNTHQGSNPFQTTGSAQQYSNINSFPSVNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0P8</accession>
    <name>G3B0P8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113203</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685257.1">
        <property type="nucleotide sequence ID" value="XM_006685194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0P8"/>
    <dbReference type="STRING" id="590646.G3B0P8"/>
    <dbReference type="KEGG" id="cten:90981913"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="58"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="293" mass="31927" checksum="EEBC0E3A277A1AD2" modified="2011-11-16" version="1">MSTITQTENGTVASVEPTTSRGYALGERGAHNIALGFNHPYPLPKFTDKHQERTWIKQHMAGAFRIFARKGYTEGTAGHISVRDPVDPNTFWINPLAKHFGLIKASDLVHVDEDGNILPDGAQTAINAAGFSIHSALHKARPDVHAACHTHSPYGKAFSALGRPLEMINQDVCTFYKSHSVYTDFGGVALEAREGIEIAKSVGNGKGAILQNHGLITVGQTVDEAAYLYTLMERSCECQLLAEAALRPGESLKIIGDEEAAYTEYSASDPDTLYTELQPDLEMEKALNPDFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0V7</accession>
    <name>G3B0V7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_113586</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0V7"/>
    <dbReference type="STRING" id="590646.G3B0V7"/>
    <dbReference type="eggNOG" id="KOG0378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_342548_0_0_1"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07407">
        <property type="entry name" value="MPP_YHR202W_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000043">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041823">
        <property type="entry name" value="YHR202W_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS4 N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 central region" evidence="10">
        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="13">
        <location>
            <begin position="212"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="287"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="14">
        <location>
            <begin position="603"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="827" mass="94736" checksum="078A775427AF80BD" modified="2011-11-16" version="1">MARGPKKHLKRLAAPSHWMLDKLSGTYAPRPSAGPHKLRESLPLVVFLRNRLKYALNGRETKAILMQQHVKVDGKVRTDATFPAGFMDVISLEATNENFRLIYDTKGRFAVHRITNEEASYKLGKVKKVQLGKRGIPYAVTHDGRTIRYPDPAIKANDTVKIDLETGKITDFIKFDTGRLVMVTGGRNLGRVGVIVHRERHEGGFDLVHIKDSLENTFVTRLSNVFVIGTEAGKPYVSLPKGKGIKLSISEERDRRRAQSVQRQQKIPENTTTAFSPIRDIRWGDINFLHTTDTHGWYSGHLNQKQYNANWGDFVSFSIQMKKKAHENNQDLLLIDTGDKHDGNGLGDVTVPNGAKSLPIFTKQDYDLITIGNHELYEWENSESEYDFVVQRYKDAYISTNVEILVNGSFHSFGTKYRYFETPINQYKILSFGFLFDFNRNNDKTKVTPISEVLQQDWFLDILKSHPSPSVDYIVVIGHIPITHEWTELDLLHKVLRKHYPETVIQYFGGHSHIRDFVVYDENSTSLESGRFCETVGWLSIDRTRSGLNQFFRSYLDFNLDSFKHHLNSSELSTKKGNDIKDLIVKTREELNLNEYLGHVSSNYYMDYVPITHPHSIFKLLTDKVLPSLEVNGAEERAIIINTGSVRYDLYKGNFTIDTKYSISPFKNDWVKLNLPKSIALQVSKQLNRKTYINLLPTSQFSYMTRNKWNFLATMSPKLGSLQQVFRSPSTLKLSKGYVTHDDFGTDGDDNIHKPTINFPVPNVVEAVQINDRKETNIDLVFYNFLAKNVLQVVKDLTGSDYSGEVQFYSRKYLGELLGEYVQQNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B125</accession>
    <name>G3B125_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_120956</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B125"/>
    <dbReference type="STRING" id="590646.G3B125"/>
    <dbReference type="GeneID" id="18248812"/>
    <dbReference type="KEGG" id="cten:18248812"/>
    <dbReference type="eggNOG" id="ENOG502QQCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020809_0_0_1"/>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="737" mass="84550" checksum="CB2698FA41480FEB" modified="2011-11-16" version="1">MVALVFTFNKSLSSVVVFAWNCFIKPFFNKKRHGPEQQNNLELFYKNQAHIYDETRSVLLKGRKECLKLAASHLEKQQDLVWVDIGGGTGANIEFMDSVIPVSSFKKVYLVDLSPSLCKVATNRFKQHGWTNITVLVEDASSFKIEEKHVDLITFSYSLSMIPTFYNTIDNAVKLLDSSGVVAAVDFGIQSPDTSLGRINTVGGLINRNLTWWNRNFWRIWFEADKVFLDSSRRNYLEYRFGTVKSINSFNKQLGRIPYYIWIGCHKSRNEHLVNRINCLVTESPYLGPLNASDVDLSNAPISKGHEALVNNISKNLPYPSMYYQKEIWRVYFDDLNPQYEQFKNQYIYAFTWEDPKEDHKILKFNENDTVLAITSAGDNILHYACLPNPPKKIHAVDLNPCQNHLLELKLACFRNLHQRDIWKMFGEGKIENFKDLLLNKLSASVSSNAMQYWMERGEKTFAAKGLYDTGSTRWALRLAKGIFTLLGLNSYVDQLCNCETMEQQCKIWNTKIKPALFNPIVGTLLVGNPIFLWKALGVPANQANMMGPSVLKYVVDTLDPIITRSLISKDNYFYYLTLKGRYTRENCPQYLTTKGYNNITRRNPKTGECALDNIRMHTDTLNDVFYRLKQGSLTIAIIMDHMDWFDPSGSDAISEVLALKNALGTNGRCMLRSAAQYPWYIKTFEENGFRCEPAAIRESGHSIDRTNMYASTWVCTKLDDSTFSRRRSSRISSLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B134</accession>
    <name>G3B134_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113633</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B134"/>
    <dbReference type="STRING" id="590646.G3B134"/>
    <dbReference type="GeneID" id="18247054"/>
    <dbReference type="KEGG" id="cten:18247054"/>
    <dbReference type="eggNOG" id="ENOG502S6U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067848_0_0_1"/>
    <dbReference type="OrthoDB" id="3998031at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833529" description="CFEM domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="231" mass="25787" checksum="947AABC53D4F68AC" modified="2011-11-16" version="1">MYLNMIWYLMSNYIMMTGVLATPPACFLSCINEMAQFCVGGHTDIKCLCGDQDSILGCLVDICPYGTFEAARDHYFGTCLEHGQPTNGRYPPGYLPPHNTTKPIKTKTWTITRPSSTEPGSPANTIPSDSSDTASGSDTDCDDEDWGYEKTVWEEEESVDSQGRTVIIRKPVSVPEKYLQPPYTDPKRRKLIILVPIQVDEASSIYSGQKQNTKKQNIKKQGRTSYARSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B156</accession>
    <name>G3B156_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_97700</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B156"/>
    <dbReference type="STRING" id="590646.G3B156"/>
    <dbReference type="eggNOG" id="ENOG502S8WJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020645_0_0_1"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="793" mass="89087" checksum="A3A1F41F2C4026A4" modified="2011-11-16" version="1">MDLSIDPNIQHHHHSDNSTEDVDTNTSPVDSHVVTSSDAPGDGNLDHVFTLNEYMKSDNDEEVDGGESNELEMIDFSVGDDASDKSTGLVDPKPSLVEYKHKEKAQRLGRPRNHVLNNIKTSPEESNQNEEKSKYMLYRLDDQPVEGPGSRGGKGDVRQKKGKITSDTLRKRKQKQAQLSFGSTGIKLLKKDTHEEEIDKDVTTEKGVVAPEKKIVKVEQNPKSVVALDTESASTEAPKKANNSVAKSGEKKKPSKEKHVVSASRTTVLNGRNKLTRQFPGPVIGLYYDLYDENVMNSAENKIASTEELALGFNVKKAPYASDVIFLVSYISKFKDIIALGNIGPQDIEKGICLEDEAEEPQEVSPLMNELFCRLVTLVLNRKPDVNPKYQGKAVSELKAVCTSLGLPYEWKDSNEMYQKFTVEEDPANIVDESNPDILIKEGYVFKPPYVYENPFNDKQGFEKLGFPGISSGIDRLIMLRTLAQWSLTASNEIKAAIVDFLQKQDIPGDKETFYASRAVLKGFKHTEDLTTEINNKIAKKKYSEDNESVARYVEPVADPMDHPLRLRLDEMIAGDVGFNVGRFFFVRVSNESDGGVSSVKKMKHIWSDLSSMRASYASRFKFYVQDTHKLLVDRLNGEGIEFTESGEEKTSEKLSAESIDSHYYEVASNSEQLELFVMHLEAKLGISVTGDIVSIIPSSSVIYKPVKALYEYLFGMLPLLKQQESLRAEARSSRKRTVDYSDVNASKKMKVYLEDDVEEQHEEPDDDEDADFHEDLDEIAQIDDDEDDDYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1V5</accession>
    <name>G3B1V5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_104074</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1V5"/>
    <dbReference type="eggNOG" id="ENOG502RQD9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204258_0_0_1"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="63" mass="7185" checksum="C714A41E51AB898E" modified="2011-11-16" version="1">MTQEDFAEAYKQLNEAELQASKLEKMLDNLDAKMDEILKEAEDITKPSAETSEEVSQTPHKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B204</accession>
    <name>G3B204_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_92810</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the mitochondrial lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685378.1">
        <property type="nucleotide sequence ID" value="XM_006685315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B204"/>
    <dbReference type="STRING" id="590646.G3B204"/>
    <dbReference type="GeneID" id="18250232"/>
    <dbReference type="KEGG" id="cten:18250232"/>
    <dbReference type="eggNOG" id="KOG1424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011072_2_0_1"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001151">
        <property type="entry name" value="Large subunit GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="8">
        <location>
            <begin position="188"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="652" mass="75042" checksum="A7FAEE5839C0E0C0" modified="2011-11-16" version="1">MNKGQLHPEQKKWKAPKGPKPIQRKHKNTIGLGRTIANQRRMENEVQILPDGELRFTTDKREADWVKLRSVTQENSLDEFLNTAQLADTDFTADKGNQIKIIKVGNTSIVNQNGLLTPEEMEQIRIKHQIFENKLTIPRRPKWSKEQSKLEIERQENLSFLEWRRDLAKLTENNDLILTPFERNLEVWRQLWRVVERCDLVVQIVDARNPLFFRSVDLVNYVNGLSDPEHNLPKNNLLLVNKADLLTVEQRVEWARFFIQKNINFVFFSAANANEQLEKQNEQLDQRIEEEEDHEDENHSHLDLDKELAEKVKILKIEELEELFISESPHFEFDPEFPDRKLQIGLVGYPNVGKSSTINALVGSKMVSVSATPGKTKHFQTIHLSPKILLCDCPGLVFPNFAYTNGELVCNGVLPIDQLREHIPPVSLVCQRIPKFYLEALYGIHIEIKKVEDGGNGEYPVASELLNAYARSRGYMTQGFGSADEPRAARYILKDYINGKLLFVDPPPRFLDNGDLTLSTLDEQRRFNMDLYSLSTLPENRRAQIEHAAKDKNIHLSEFELAKDLSKLNFSMHIGETKEPTKPQAESAKTLFYGGKQAKLESAGDELDKEFFGMEDVRGNVNKPFHLQETSSSKKHNKKNKKSAKKVRVVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2J7</accession>
    <name>G3B2J7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_120547</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2J7"/>
    <dbReference type="STRING" id="590646.G3B2J7"/>
    <dbReference type="GeneID" id="18248787"/>
    <dbReference type="KEGG" id="cten:18248787"/>
    <dbReference type="eggNOG" id="KOG0201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="7"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV64695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="410" mass="46108" checksum="B988F136ECA89075" modified="2011-11-16" version="1" fragment="single">MSATELFKRTEIIGRGKFGVVYKALNRQTKQVVAIKVLNLDTQEDEVADVQQEVQFLAELKNVPNVTHYYGSILNDTRLWIIMDYCSGGSVRTLLKAGVFEEKHIGVVIRESLIGLSAVHKLGVIHRDLKAANILISKEGNVQLCDFGVAAKVSANSLKRTTMAGTPYWMAPEVIREGDTYNSKADIWSLGITIYEIATGNPPYCDKDASWAMQMISKSTPPRLEGRDYSPNLKEAIALCLDENPEERPSADDLLKCKLVKFYRTYPTVTLKEVISRYLVWRDNNNRKDSTVFVSLENDLGDPQAEGDPGDANHIQVKWDFDSLSSREYIIENDIDLDGVDDRLDNTYSLGDYQNNDTYRTEPTLKADQYTSTLRNNYSHYDKLLKAAPSSAAPKNDIPISLQSLFEESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2L6</accession>
    <name>G3B2L6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113492</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685514.1">
        <property type="nucleotide sequence ID" value="XM_006685451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2L6"/>
    <dbReference type="STRING" id="590646.G3B2L6"/>
    <dbReference type="GeneID" id="18246988"/>
    <dbReference type="KEGG" id="cten:18246988"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028601_0_1_1"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="232" mass="25842" checksum="914175A657D90F0D" modified="2011-11-16" version="1">MEKSTVYVGNIPYDYTEEQVLEIASSVGPVDDLRLLFDPVSGKSKGYAFVKYSDRETAASAVRNLNNHSIGNRNLKCSLSNETSQFETGIENEELPPLPLGVQIFPNQTTGQVISSILSTLDEQTASQILKEAKDMSSTNPIMMERLLEKCPQLAHALAETAILLNVTTPETVEICINRKKRPIFQLSPEQINTLRAVKQLKDDDIQDLEKSKQEIMIKLKTEINSDSFGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2Q3</accession>
    <name>G3B2Q3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_134045</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B2Q3"/>
    <dbReference type="eggNOG" id="KOG3687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003828_0_0_1"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1370" mass="155750" checksum="6881BDDCF51FCD00" modified="2011-11-16" version="1">MTESLKKFTISSIPEIWYLARDMCEPKIQSYIRRVTLKLLIECIKNDDLTSTSTKLMYFRDIVAFCQLSEFKTDQEFDLFLNALRNLTQDGRDIQELYIYEGFSSLPQFLVTALAALGRLAKNYTEKSTEKELEEDVNYQNIIKLLAFIKNCIKFNPYAFDDSFTINISKKAIHIASRTTNNNILVHCIELLSTTVIFTTIPQAQLFEVIAYMCSVFGSNEKSTRMVWDAITILASHSSFYLLRNCLIEILTNEALSTFKTTESENALSAVKSNTTISTIEHKPSNSALSSCVGAIQIIERLAVSPSVSKSSDSLLVHFLPALVEMSSLNVPALNTTILRSLDRLFSKNSYSTLSEANVNAMEHVYSFQLWYSSKTSIYELLTNIKILSEIDVSYWKSICMSLQHAHEAHELYTPKERLVNLFTRNHQYLPNETIKYVLKYYSEEKWLTVLNPFAQENTFKLLNYFYFTNGSHPGSDLVSAEDSSDIKVEVLKCIKGSFDISYAISKSEFNFEIVVDILKRSLNEKDEKVLDYLINEIFVKAVMKAPFQTLSQIVDEIVPYFDVRYNGRLRSLVSIESSALKTHSSNSMDTAIPGKISKPFKLAITKGFIKLLIIESTEDAEKASETFRTCILMAKHALSIEDSELLLVVLKGEKLQMDLEVWFSIVLDIMTHFIEWEVYSFVWAHFCPQLSNMKLFANSREQILSLKKVVCDQLLLNLPSNIKFPEGFTKSHLQVAYVRVFSSLIGYHRLFSKHDEDDIIRALVFGIDSWEKTAIPSIHILTACCYEIPLSIKKYLSTILAKLQTKVTSVFVSSHILEFLMSLINIPSLTASLDIDDVKRIFGISFKFVQYATDAIKNTGSTEDKGLVPQHGLDAEIDNTPSTQRFQEHASVLLQYVLTLSYNVISTWFLKLEISVRGKLSSFILKNLVAINSNNKELDDQVIAYVDLITRFTYSNLPLKMVNPKAALDQLKSEEGTVAIKSWITGSVIVTIGTNSDTGKSTVVFRRPTGATILQMALDERMLSSKSKLSKSQTLSPNFLLLQTFNHIDGDHKYRPIPLMDDAVTTRAITTLDRIPIVEFHKIGLVYIGRGQIKEKEVLANRGGSKSYQKFVDAMGDLIKLKNCKDIYVGGLDTENGTDGDFAISWSDKTVQVVYHTTSLMPNPDEDIYFEHKKRHIGNNYVNIYFDESGHPFNFNLIKSQFNFINIVISPHTKSFHTYNKEPIEETTRLFKIKLLRRSGVPGVFATCHFKIFSEDVLPAVVRNLAITANQFASVWHANYHGQFVSNWTHRVKSIKVLKERTIQSHEALKQEQLNQEDSKLGVNDATQSFLEQLQFGTVSSTIESSHRYEYVKDSDNELYSVVEFNSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2S9</accession>
    <name>G3B2S9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_113530</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685925.1">
        <property type="nucleotide sequence ID" value="XM_006685862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2S9"/>
    <dbReference type="GeneID" id="18247005"/>
    <dbReference type="KEGG" id="cten:18247005"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032218">
        <property type="term" value="P:riboflavin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="49"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="455" mass="49409" checksum="8CD1A15120E8E154" modified="2011-11-16" version="1">MNHEEANFETMRVRQQAPGTGSEIDTQALGTTAATPDKDEIKYPDGGRNAYLAVIGSFFGSVTCLGLVNAIGSVQAYVSSHQLSGMTTFSISWIFSIYLSLSYALGLAIGPIFDHHGSQAILVFTTVFVFAGLMGAASSTQMYQFVLSFVSLGIGNGAGMTPVVGVINHWFLRKRGLMTGVVTCGGSVGGLTFPLLLRFAYDKYGYEWAMRILAFINLGCMLVSVILCKERIIRPPTSKFGKRINVEQMLQKVVAVLKRNNDKTFWLTMMASFFAELSLVLVVTYFVTYAMAQGVPESTAYLLSTIWAAASIPGRILPGFASDYLGKFNVHIFMLSGLNVCFFGIWYAFGHKLSVLYVFACVAGFFQGSTSGMIPACLAQITRVSEFGERFGILNFCLSFGNLLGVPIGAAIIRRGSVEEYDNFVLLVGGLGVASVVLYVLARYTLVGVRMNVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2Y8</accession>
    <name>G3B2Y8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_93545</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2Y8"/>
    <dbReference type="STRING" id="590646.G3B2Y8"/>
    <dbReference type="GeneID" id="18250300"/>
    <dbReference type="KEGG" id="cten:18250300"/>
    <dbReference type="eggNOG" id="ENOG502RXQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1396132_0_0_1"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2790">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="195" mass="22945" checksum="E8E64E15FC164EC2" modified="2011-11-16" version="1">MFFDDEFKPANYIDALFKDYDYSKTSMAKLTMISNNLTIHLNFLMEQLNREINEKLLALNNIAHEETLNNSTRLNYYIKLLQNSIISLNNELQVPEFNQLVIINKLIDFKVVKQNMLDTLKILNYIKKNFGDLTLRYFETDLLKLFSSILKLQDADDKQANLKTLVDCADVFKNMNHFNSIYKRNMSKFTSEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B359</accession>
    <name>G3B359_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_134665</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B359"/>
    <dbReference type="STRING" id="590646.G3B359"/>
    <dbReference type="eggNOG" id="ENOG502QS09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591826_0_0_1"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="2">
        <location>
            <begin position="387"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="462" mass="51029" checksum="FAE6A89C8AC7411D" modified="2011-11-16" version="1">MESTRAADSPDPTLMSSGSSLVSSGNLVSSDPLVSSDAPSTSLRQDDQSASKHHIDEDDDFFMLKPRKKSRRRHRHSDMKAKALEPTGTEPTGTEPTGTEPTGTETAGTETGIEITETQTQPTQTTQTGAGAVTPSPIELSSDSPVYHDADEDFTATVAVPASHRRTRQSTRSSPPPKPNPSPPSVALRHSANPDDFARIMESVRQLRTESQLTYEFSPHDEENRPYLLNVIPKVHTTTPNSFATKGNKSFKLILQSILLHYKRIGQFPKNARVVDYTLFWIHGRRELKHFFRPSTLRIYPPPEDSLVYVNGIGYTALDCLLISRSMAANALDTFDELKTKYETLIGLNETYELGEADGNDSVDIISVGDTDDEDERQQGVGGSSFTIFLKGKDNKRMPVSVTAATPTINLLKYYFEKSGVSEVTDLESGILVFDDEPMDLSDVVGHTELEEDFEVEVHFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3G6</accession>
    <name>G3B3G6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114203</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3G6"/>
    <dbReference type="STRING" id="590646.G3B3G6"/>
    <dbReference type="GeneID" id="18247311"/>
    <dbReference type="KEGG" id="cten:18247311"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032690_2_1_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="179"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="320" mass="35924" checksum="E4F6AB75A5F294E2" modified="2011-11-16" version="1">MSVSVSGPSRSQQQLEVRQIGELEFEGVRPLGKPSPNSRGVYGGNLCAQAILVAMRTVDSDFVPHSLHSYFVAAGDDSLVCEYKVEKVSTGNNFANRLVKLYQKDQLKYLVMISLTKKNSIDKTAQAFDKTGKGPRPFEYQLPVKSSAFKHNLDEIPLLSSDPDKLVQHKLTPEFVDIDEADELSKAPSERTLGFYIRLNDQELPTQYKYATMGVVTDSLYLTSISRILHLPRINNNPLGSSGGANHNFFSISLDHSIYFHDDDFSPTNWLYFQYQSPRFSNNRVLFTGGYYNSKGKLIATIVQEGLVFFKNDADLKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3N4</accession>
    <name>G3B3N4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_134781</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3N4"/>
    <dbReference type="STRING" id="590646.G3B3N4"/>
    <dbReference type="GeneID" id="18249813"/>
    <dbReference type="KEGG" id="cten:18249813"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043550_0_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="453"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="490" mass="53896" checksum="2D18EFBD5F6A3D26" modified="2011-11-16" version="1">MSNVLEDPQLDLNISSNISNDHVSLLDPALEYLDDSTYDGGLADYNDNGNYTHSNISNTSNTSNTTPEFSSPNDAHYANYHYNAAATAAPAMNHPDNYYDYTHLTGFKSHVKSQSFSLPDKLNLLSLQNISQDSSKSPSPEFIYHAKDDHDDRTINPKQLFTIKNVKPAAISTASVQGATAVVPGTGAGVSRKNKRKSMDHEETLTFDPPIADTGMHPDERREYVLPSSSSSPNLSTFFSQYTQRNLDMDFKMNNECFNAIKMWLNNNDLGSNGNNEIVINPTGIIKNTSTLSKRRNSIQSVNASPAPVTPAIEKRKRRKSTNSNATLTEFKASLFSMDVHELDHDLEVSLSPTDRNSRESTSKSSSQQPGSAGVGVGSGDDETGKPFPCPECNKQFKRSEHLKRHIRSVHSNIRPFHCKYCEKQFSRSDNLAQHLKTHYKLNANGTTSIIYGNPNLHNRGGRRKNSGSNGVSGMMGPGSPTQPSSTGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B473</accession>
    <name>G3B473_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_113833</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B473"/>
    <dbReference type="STRING" id="590646.G3B473"/>
    <dbReference type="GeneID" id="18247139"/>
    <dbReference type="KEGG" id="cten:18247139"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022817_0_0_1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001752">
        <property type="entry name" value="Transcriptional factor SWI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="488"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="251"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="567" mass="64366" checksum="8CCBE52426F487CE" modified="2011-11-16" version="1">MEQFSNWVDIPNSSELIKNQDLDQYLEGINPDIDDLLNQTLLGIQDLDVPTGFPNDLPQHSSPKRIESNHHHSAGNSFHFHQARHSRKISGTAIFGFENHTRELSIELKNDDKSISPVQLVRMASTSAMSSPLRKSISAKPVNVLIEEEDPKPSSKKSSDDYLVPNNNPNSYKFPPSPDTSDNDRRSMNPGNMYSAKYLQELSRLNHSQPEQVYVDDIEPLLEEDDKAHMKYVPIPVQDPSPRKKQAFNANANTYLPPPSPPRLTNDSPDQSSPSPRPFTRESSPVNLNGNLNSSPAVSYFYNPQFFSDDNYFNDGYSSPINSQSLSSSPLKADYYSSPLRNVPVNTSENIDVNETITQLTPLKPSQTPMTPSRNKIMLEWSPIVSPSVKNNRDVRNAIKQSSPKRRIKKTSLLPPGELDRYFDGPDSNKTFTCTYKNCGKRFTRRYNVRSHIQTHLSDRPFPCMYCPKKFVRQHDLNRHVKGHLEARHCRCPCGKEFTRIDAMKKHRLRNICSGRIPPDQADSLRSPERQDDSPLDDYSSPARIVESNENEITNNLLQNLNDIPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4A3</accession>
    <name>G3B4A3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_93441</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4A3"/>
    <dbReference type="STRING" id="590646.G3B4A3"/>
    <dbReference type="GeneID" id="18250290"/>
    <dbReference type="KEGG" id="cten:18250290"/>
    <dbReference type="eggNOG" id="KOG3355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070631_1_0_1"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="67"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="172" mass="19697" checksum="2BC9A077CCB45D04" modified="2011-11-16" version="1">MSSQNAPLKAPEVGISGKKIVYDKDGKPCRTCNSLLDFQMVTGKISPGAAVKAQQKLHQDPQSSTDFPPDVEQIGRSSWTLLHSIAATYPEVPDSQKQQDLKQFLKLFGNFYPCWFCADDFKSYMTKNEPKVSTQEDFGRWLCDAHNEVNVKLGKPKFDCNFWRRRWKDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4B3</accession>
    <name>G3B4B3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_104606</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4B3"/>
    <dbReference type="STRING" id="590646.G3B4B3"/>
    <dbReference type="GeneID" id="18245732"/>
    <dbReference type="KEGG" id="cten:18245732"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010084_1_0_1"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="860" mass="98156" checksum="59756791BDB02617" modified="2011-11-16" version="1">MNFTKLDKEPKRRRVTRACDICRQKKVKCDGKQPCIHCTVYSYNCTYDQPNIRNKKNSGIPYPPYSRIVAKNGGSISSDPAKNATSLMTFQNIMDMMFPGLKVNVLDDSPLNLNFEKFKRVMSFLQQSRGSNTTLKDISDCYLDNLDAVRNFSPSNSPWDYSRERDKESITSDDNPVGREIKIDLPSKEIAVHLIQTCWDKACVLFRFYHRPSLLEELDLLYSLDPLHYTDRQQKFLPFLYSILAVGCLFSRESYGSTQDNDLLEDDGFKYFLEARKLIDITNVGDIISIQTIVMMIMYLQCSARLSTCYSYIGIGLRSALKEGLHRNLMIFQDTKRKLDPIEIDTRKRLFFTLYKMDIYINSLLGLPKSLSEDEFDQMLPEELDDENITRQGYHHEAQQGRLSSAACANHHTKLMFIMSHIITHLYPLKVKKSPNSNNVNQTPNYMHQKVSKLEHEMKQWLDQLPEELKPYDPNNVLLSHDVPEKFQLANYYLHLAFLNCQIMLYRPFIHFISHGNDSKASDPRSLIRGRNCIKVARSVVKLANRMIDQNLLVGTYWFSMYTIFFSIACLIYYYHFVNSSHNLNDYNSSSNYAGVLFDDDLNLDMIKKDIEVGKKVLDNLKGNSNASLRIYNILNQLFEQLNRRTASTSKDISNLLTNTPVSDVNKAQISNTISAFDSINNFKSKGKNYDQTSLFQQNFNKQLDQLNLSDPGRDDNQNEYTPYSMKQSVSQPVVSVSAPVIQSQSVPATASDSAITKSTRAFTGDDISSIMNDYSATTSVGSGSGSTPAASNSANPTNYHHEDTHTYIPGVMDTLDAQIFGRILPPYMQGAEDLNLEDLNELIGGYGNMDNYNFDDMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4D8</accession>
    <name>G3B4D8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1742-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_93312</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686113.1">
        <property type="nucleotide sequence ID" value="XM_006686050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4D8"/>
    <dbReference type="GeneID" id="18250273"/>
    <dbReference type="KEGG" id="cten:18250273"/>
    <dbReference type="eggNOG" id="ENOG502S7NV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088285_2_1_1"/>
    <dbReference type="OrthoDB" id="2158714at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="190" mass="21782" checksum="4E382088A47945DB" modified="2011-11-16" version="1">MSVPFTNEYKLRQVADSQSKSCVICYKSSSSVLVTTNSVDFFYVCPSHLADEHFAVHSVNDAYNALVKEKDELVELVTQLKVKIEKNKPSVFAKLPGFSSSNEGDKDKDKDKTNTYETLTKEKEIHEKKLQQLDTDIANFKFKDYVLNNDIFRMRLKNYINKKINEKRLKDMHNPGFFPAAPTSKLGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4R0</accession>
    <name>G3B4R0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_97883</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4R0"/>
    <dbReference type="GeneID" id="18250721"/>
    <dbReference type="KEGG" id="cten:18250721"/>
    <dbReference type="eggNOG" id="KOG0719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055868_0_2_1"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="287" mass="33641" checksum="9C1AB581BCF6D1F2" modified="2011-11-16" version="1">MAVPFPDIDPYEVLGVSNTANPIEVKRAYKKLSLKYHPDKLRQQQISNNNGDDTNDLFPKIQFAYSVLSDHNRRQRYDATGSLAELEEGEDSFDWKEYFNSLNEKITVEMIEEDRLKYQNSEEERSDILQNILFYEGDFLKLFEVIPHLEFDEREEERVFVIVEELEQQFPQEFSKNAVKSIAKYQKSRKTKVKNQLKKLAKEAKEAEKLEKLIKGKHKGNDLQAIIRARQSSRMDDLISNLESKYVDKKGKKRSNVSDDEFNRIQQGLLNKKKNGFKAFTPTFTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4V7</accession>
    <name>G3B4V7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">37S ribosomal protein S35, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113903</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686594.1">
        <property type="nucleotide sequence ID" value="XM_006686531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4V7"/>
    <dbReference type="STRING" id="590646.G3B4V7"/>
    <dbReference type="GeneID" id="18247173"/>
    <dbReference type="KEGG" id="cten:18247173"/>
    <dbReference type="eggNOG" id="ENOG502QVMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842157_0_0_1"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36847" checksum="50B9C4F3E5B50384" modified="2011-11-16" version="1">MFSHNPVLGRSSHPVVRCGQLQHLRTLKRRLAYPEAYRPVVPPQTGKKDHSSYFQRALKGWLGPKNIRGEYYRNKYYYPPQNHKPRYIVQDGQSVEDGNQPTSRSFGSKGRDPALHPFPQNLQCTTAPIISEELKLTVYEDANVRGLKTQEIAQKYGIKLARVEAIIKLYEIERSWEENNKITTDLKQFSTTMYKMFPLFNPPLQAENLTEIPTPSRTLHQRFLTISESEPFGPVDAADIFGLEPASETLTKLTQIQDHSQQNNSVVLNKVLVGKQKEGDRTAFRFSHAQSGSVGYRYGASRRDRKKDKAIGFDRVGKLVNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5E8</accession>
    <name>G3B5E8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114517</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686996.1">
        <property type="nucleotide sequence ID" value="XM_006686933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5E8"/>
    <dbReference type="STRING" id="590646.G3B5E8"/>
    <dbReference type="GeneID" id="18247461"/>
    <dbReference type="KEGG" id="cten:18247461"/>
    <dbReference type="eggNOG" id="ENOG502T0P1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377950_0_0_1"/>
    <dbReference type="OrthoDB" id="4096040at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442738" description="Cell wall protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="19813" checksum="184BE93495B30252" modified="2011-11-16" version="1">MFKFTLLLTLASLVIADQTISITSSNGISGNVVIINNRLAVGDGNNEWLLAEPSGYLSQGDQYVASTPTGLVVGSQSEASRDWGIEDGNRLRSGVNQPNFYVCASDGINYLSGVVCSEGETQTQVTLLVGESSDASSAAPASSAAPESSAAPESSAAPESSAAPEASAAPSITTTYDGGAGKAAVGVAGFAAAAALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5V0</accession>
    <name>G3B5V0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_98452</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5V0"/>
    <dbReference type="STRING" id="590646.G3B5V0"/>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099529_3_0_1"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="208" mass="23303" checksum="6122EB2247CF7071" modified="2011-11-16" version="1">MNFFKSFGSNYTALSTDDGAPLPPPATEPTQPNSFRTRMSKLNPFRNNSVYLEDDDNYVTSEPGYFELSRWDRMLIFGLTFGGSVCCYLICIFLFPILSLKPRKFALLWSLGSILFLVSFGVLQGTKAYILHLFSSTRIIFSIVFITSIMMTLVCSVGLKSTLLSIIFAVIQLLSAIWYTVSYFPLGKQTLNLASSVARSQVDSWISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Z2</accession>
    <name>G3B5Z2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cerevisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_123476</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Z2"/>
    <dbReference type="STRING" id="590646.G3B5Z2"/>
    <dbReference type="GeneID" id="18248957"/>
    <dbReference type="KEGG" id="cten:18248957"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000011">
        <property type="entry name" value="Vacuolar protease B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442782" description="Cerevisin" evidence="7">
        <location>
            <begin position="20"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="87"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="219"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="58917" checksum="BC9F0407A44E5B9D" modified="2011-11-16" version="1">MLLTKSVALSILTSLGVQALVIPQAHDVIDVFGDNTNSLKESVAQVTESIKETSKEVLNKLKIELKELKDAAPITFVDKERDIIPHKYIVVFNDGTNEDEAGFHKEWVALQHVNSLAAIKENPEHTFFDATKDFTTAGGIVDSFNVGNLLHGYAGYFLDDTIELIRRHPAVKFVEKDSMVYANEFDTQKGAPWGLARVSHRQPLSLNSFNQYLYDTEGGEGVTAYVIDTGVNVDHEEFGGRAVWGSTIPYGDSDVDGNGHGTHCAGTIGSAAYGIAKQAKIVAVKVLRSNGSGSMSDVVKGVEFAAKSHQDEAKAGKKGFKGSAANMSLGGGKSTALDLAVNAAVKLGLNFAVAAGNENQDACNTSPAAAENAITVGASTISDARAYFSNYGKCVDIFAPGLNILSTYIGSTTATATLSGTSMASPHICGLLSYFISLQPSADSEFFTAGDSVTPDQLKKNLIAYGSQDLLTDIPEDTPNILAFNGAGHNITDFWAEEAVTVESKVNLDSKVSSKIEKIEDAFDEFLSSVGKSSAPVLDEIDKLINNVYGSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B642</accession>
    <name>G3B642_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_135198</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B642"/>
    <dbReference type="STRING" id="590646.G3B642"/>
    <dbReference type="eggNOG" id="ENOG502SBXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084830_0_0_1"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="219" mass="25036" checksum="5C451DD2A96A6142" modified="2011-11-16" version="1">MSGQEIPKITDPKALTGVYKKRGAFDKQRKTLLENFKSSETHSNLLLKLKLMVESKVKNNPDILMKNKGKMAALIQGEIMSEHNSKDSTSLLSIVDKDIQEKIIDSPEFHELLRKELKEVKRREEGITDEEFNRILEEEHQQEQQKKAQLQKDKEIHNSDKERSSYRPNKVTKAPRFKYNSVNTSRNSSTNKEGNSSGNSSTSAGSTNEAPKKGFHLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B671</accession>
    <name>G3B671_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_135217</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B671"/>
    <dbReference type="STRING" id="590646.G3B671"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_662210_0_0_1"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="318"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="415" mass="46524" checksum="9CA5DE2853493BBE" modified="2011-11-16" version="1">MRQGPTSIHLSGGPDCVDPLEDPDFQHRLGTLRQLQEVFPEKPRRVLALTIKSHPAASIEELVQLVLTSHEPDQNYPHEVYILLEMFPNMSLGTLNAAFVTNGSNMDLAVLNLVGNEVVGSAGFPCSLGQIVRTTGMDEATCKKYLDLNKGDYGKSFIELVINEVDLGSSESATRSRVNRGYNCKTQYVYDEGLPEFRELEDFYNTNPDFRLISKPFLKKLLVMFKGDLNKTVEMVGVIITAMYERQTFAGEWFTGEEMPKLSGPKEKLGSKVDVLKIPKAGQRLLQQTEAKGLQRIPNRGVQTSLSPVSKISHLHSIDLHMMGVSDAMQATTMALRDWWAQEQQERIEDGKLSHYGTKAQFVEPLRVVTGRGIHSAQGYSRIKVSVGKYLASHMYMYTEETWGYIILGKRKDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6I8</accession>
    <name>G3B6I8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_135285</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6I8"/>
    <dbReference type="STRING" id="590646.G3B6I8"/>
    <dbReference type="GeneID" id="18249862"/>
    <dbReference type="KEGG" id="cten:18249862"/>
    <dbReference type="eggNOG" id="KOG1243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010392_2_0_1"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="386"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="718" mass="79892" checksum="638A86C739B45257" modified="2011-11-16" version="1">MDFLSKTLQTLTGSSIPYTLKEEVWHNQIWQLFDAINPKDNSPVSVFQFNGANKQDTYKVLATSSFTNSKLVKYPGLVSIIDYFEVSKEHLYIVTERVKPLSAVLSGSSKDYKVFGINSIANSLEFLNSKCKLVHCNLSVDSVFVSLEGSWKLFGFELMSGVGNMAKNAVSYGRNLIDLPEELVNSQLCNYEASPQTDSYLLGKFIEANVPQWTSPTIKRLTTKFRSRLSLEDFLVKNGPIFDSNIIIRFNEELNDVKVLNSHDKLGFFKHNLAEYLNGDTSVYPEGLIANKLLPELVSQYDQLSRFKPSVNTTPEETTQNQELLSIVLNFILKICMNLPSSEFNTKIVPIIKASFGSNDRSVRLTLLNNLSGYRPMLSNPDLQAIFPKLVVGIQDSNFIIRELTLNAINSIVDVLTDKSVNQDLLKVLAKCQNDPKPSIRTNTIILIIKISGRIYKNSRNNVLITALSKSLKDSFTPCKMAALRGFESLESDFSIDEVCNKILGILATALMDPKSSKVRNESGRLFKVYFNRVESQATNLGDEEDEELEEKEFLAKNGTPNETVKKDVAPGNGGSGSGFGWNLMNKFVSSGVEGQMNNEINKSSSTVNLIATNNSNSARNTPTIASVTHSTEDLTIKDGWNEFDDGWGGVEDEELEKPKPRAAKSTKPVNTRKPISSNRTKTSTLKLGHKEKPVSSLKLNLVDDDQEEGGWGGLDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6M6</accession>
    <name>G3B6M6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_93746</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6M6"/>
    <dbReference type="HOGENOM" id="CLU_1539812_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="174" mass="17892" checksum="5E71334086965C5D" modified="2011-11-16" version="1">MGAPELTSGEALVPGASIISTRSLSPSEALSSHSSIKSETSDILTEPTTITYITTTTKTWEVYTNDEENTASGAGRSKVPDGKVISHDENEGAVTFTSISTGTIEVIVTTDSNGQPFTTSQEISISADTAGDLGFSTATSSTASPTVSALEGSGSTRNSSWLLFFSVVALLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Z2</accession>
    <name>G3B6Z2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114368</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Z2"/>
    <dbReference type="STRING" id="590646.G3B6Z2"/>
    <dbReference type="GeneID" id="18247392"/>
    <dbReference type="KEGG" id="cten:18247392"/>
    <dbReference type="eggNOG" id="KOG1154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_1_1_1"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000008">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000020">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="10">
        <location>
            <begin position="307"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="415" mass="45228" checksum="B2BAC0F8C6C69FF0" modified="2011-11-16" version="1">MPPCYTIVIKLGSSSLVDEVTREPRLANMSRLVETMVQLRRQGHRIIVVSSGAIAVGMRAMGYTTRPSKLATVQALASVGQGILIGLWDNLFKQLSQPISQILLTRNDIVDFTQYRNAVNTINEVLEMGVIPIVNENDTLSVAEIKFGDNDTLSAITAGMMHADYLFLMTDVEALYTANPRSDPMAQPILIVEKVEELQVNTDTDAGAGSGVGTGGMTTKLIAAELASSAGVVTIVSLSSRPEYMLDIVADIQDNEGTSVEEMKQKLADKVKKGHIPLHTRFLSLPRDHAIKSDKKFWILHGLKTKGSLIIDKGCFQALSRKNRAGLLPAGIVHVTGVFHESECVSLMVVDSKTSPIESAKLVGQCRVNYSSVEISMIKGCQSHEIEHILGFADSEYIAHRDNIAFPPLVEEVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B761</accession>
    <name>G3B761_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_106147</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B761"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="34"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="492" mass="53816" checksum="23B45BB4A44E2B68" modified="2011-11-16" version="1">MFDATDFSHNYLIKTALLSKAMDEIGFGRYQYGLFFVAGFGWFADNAWPIVTSLIIPVLTETDGVHPPTGKGPYLTLAQNLGLLVGAAFWSLSADIIGRRWAFNLTFLITGVWAVVAGSAPNFGALGVFVSLWSVGVGGNLPVDSALFLEALPSTHQWLLTVMSGWWALGQLVANLISWGLIANFSCSTDSKVCLKADNKGWRYFLFTMGGLTLLFFIARFSFRVFESPRFYVARGRDDLAIDTLQKIAKINGTEVSLTLDQLQKVDEKYPEESTTKNHLVKEKVQKFNLEHLRNCFHSRKIAISSALVIFTWAIIGLAFPLYNAFLPYYLQTRGDANKPLSVHDTYRNSLIVSVIGIPGSIVAGFSVETKIGRKGTLIVSLLLTGVFLFASTTAKTSNANLGWNCAFSFVSNIMYGVLYAYTPEVFPAKIRGTGVGLAASANRILGVFAPIIAIYADLTTSAPIFVSGALFLASGVLVFFFPYEPRGHSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7F4</accession>
    <name>G3B7F4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_131638</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B7F4"/>
    <dbReference type="GeneID" id="18249543"/>
    <dbReference type="KEGG" id="cten:18249543"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_19_1_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd17647">
        <property type="entry name" value="A_NRPS_alphaAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000046">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000035">
        <property type="entry name" value="L-2-aminoadipate reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="840"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV62262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1382" mass="152451" checksum="C5FF4E84EBD74A4E" modified="2011-11-16" version="1">MSQYWLEYLDNPTLAIFPFDYLRPSNNKVIEASYEVPVSGKDYITSLTSFIVLIYRLTGDEDIVVAVNAEDNHKEFILRLSLTPTTTFSDFRSRVLDEYTKNQKQAASYNSLDDIAQAIKEKKGTEEYPNLFRLSFEHANSNAQLATSVRGSIRDLAVFYSSDKIQIFYNGLLFKQERIAMFGEQFAGFVEAAEKNPSIEVSKVSLVTPSQAKFLPDPTVDLDWAGFRGAIQDIFMENALKHPERTCVTETRSFMDPQSKTRVFTYKQINQASNIVGNYLVKSGIKKGDIVMIYAYRGVDLMIAVMGVLKAGATFSVIDPAYPPARQNIYLSVAKPRGLIGLEKAGVLDQLVVDYVKYELEVVASIPQLKVNDDGSLNGGVVDKLDCLQQYAQYADVPTGVKVGPDSNPTLSFTSGSEGIPKGVLGRHYSLAYYFPWMSQRFGLSADDKFTMLSGIAHDPIQRDMFTPLFLGAQLLVPTADDIGTPGKLADWMAEYGATVTHLTPAMGQLLSAQASTAFPKLHHAFFVGDILTKRDCLRLQSLAANVYIVNMYGTTETQRAVSYFEIKSLAADPTYLKSLKDVMPAGTGMYNVQLLIVNRNHTSQTCGVGEVGEIYVRAAGLSEGYRGLPDLNAQKFVTNWYVDPNKWITVDEANSQNEGWRQEGWLGPRDRLYRTGDLGRYLPDGNVECCGRADDQVKIRGFRIELGEIDTHLSQHALVRENITLVRRDKNEEPTLISYIVPKDSEELKNFKSEIEDDSGLDDPIVLGLVEYRELIKDIKGYLKKRLASYAIPTLIVPLAKLPLNPNGKVDKPKLPFPDTAQLAAVAKLSKSTSSESEEDLNEVEKLLINLWIEVLPNRPATISRSDSFFDLGGHSILATRMIFELRKRVGVDVPLGIIFSNPTIEAFGKKVSAYIKGNDFELADSSANKEEETAAPESNYSEDAKHLANTMLLEKYPTLENLDTSQHINVFVTGVTGFLGSFIIKELLENEQLSVTIYAHVRASDENKGLDRIRQAGKTFGVWNEAWASSITVVLADLSQPKLGLSDSAWTQLANNIDVIIHNGAFVHWVYPYSQLRDANVIGSVNLMNLCGVGKAKHYAFVSSTSSLDTDHYIRLSDQIMAKGGDGIPESDDMEGSATGLGNGYGQSKWAAEYIIRKAGERGLRGSIIRAGYVTGYTRTGASNTDDFLLRMLKGCCELGIYPDIGNNVNMVPVDHVAKITVATGLFPPTAGMGVAQVTAHPRIRFNEFLGALNDYGYGLKQDDYPLWKNELENFVVNKSKESALFPLLHFVLDDLPQNTKAPELDDSNTSASLAAYKSNSVTSRGVTQELMGTYIAYLVKIGFLPAPGGYGKPLPEIELSDESLSLILAGSGGRGSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7I6</accession>
    <name>G3B7I6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_124540</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7I6"/>
    <dbReference type="STRING" id="590646.G3B7I6"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013661_4_1_1"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="467" mass="52524" checksum="B14C56A88843DCA3" modified="2011-11-16" version="1">MAHISSLSAMSLIVNKMVGTGIFLTPSIILQYCQGNVGLYLSLWVIGSLVIACGILIYLEFALHLPIKNGGEKNYLQRIFDKRLIGFVYAFQIVLLGFSSGNSYAFGKYILYSINGDLGNESSLNNFYVKAIGVLCISYCTYLHIFHHHQSNIFFIFLGVSKILILLLIIVCGALVFVGAIDLPQTHNFSHMFVSDSPPNYYSISVALLEIIYSFKGWENVNYVLSETRDPYKVLTRSAPLAVLITTVLYFLVILSYLVVIPKQEIMSSGVLIAGIFFNKIFGQNITSRVLPLLIAVSNFGNVLVVSYAHSVVNKELSIENLLPFSKTFTRFSNALLLHWLVTVVVLVLPPSAEIYEFIVNLYIYPGTWINILLTGGLLYLRYFDPTWSAEHSEFDHLLAPKTTRRISTPVILILVFLAANLFMALFPFLQPPNYTSQIPYWCFPVLGTGSLVLGAIYYLFTERIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7U5</accession>
    <name>G3B7U5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_108823</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7U5"/>
    <dbReference type="STRING" id="590646.G3B7U5"/>
    <dbReference type="GeneID" id="18246063"/>
    <dbReference type="KEGG" id="cten:18246063"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017361_3_1_1"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF23">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ICT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="116"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="459" mass="53043" checksum="23E334226909912C" modified="2011-11-16" version="1">MGDRAQTPPGALSTNDINSVSLFQSINDWWTTSSALMKPTENTPAYQTARIKNLLIEYDLYMAILSDDIKINKPGELPKYTQDGIIVGSFKDTELEDGNFIHEFNLENRHGAPSETIVIMHGYMAASGYFVKNFEALVKSKPGSRLHVIDMPGFGNSSRPRFPSELLQNYPDKYNQINQVLGVENWFIDKFEQWRIANSIDKFKLISHSMGAYLSCCYLAKYNFNQVSEFLVVSPMGTESNYTSLLNSKDLQVNHHELGGRPLEELVQQQSENGEVHDNDELTKLWESLGRPKFPENLVLKKLWEWKISPFQLLQLFGPMFSKFLSLWSYQRFRNLKDSNGETNHDLLLKLHYYSYSIFNQYQGSGELAITKLINHEILPKLPLCDRQIAEFFTENKIKTLWLYGEKDWMNFKGGEYIYKKLKELGADAEFKIVENAGHHIYLDNPEEFNKIALNFFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Y5</accession>
    <name>G3B7Y5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">37 kDa cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115146</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687858.1">
        <property type="nucleotide sequence ID" value="XM_006687795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Y5"/>
    <dbReference type="STRING" id="590646.G3B7Y5"/>
    <dbReference type="GeneID" id="18247741"/>
    <dbReference type="KEGG" id="cten:18247741"/>
    <dbReference type="HOGENOM" id="CLU_725841_0_0_1"/>
    <dbReference type="OrthoDB" id="4085621at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36291" checksum="19131FE0817204E5" modified="2011-11-16" version="1">MKKAIPFIVAAGALYYYDQNVDPIISRNFHRSVPAKSASNPIEVFKKSEPEKATDSVKAATSQFSKDIESKYNQFESKTSELANRLSSTFVEKKDDVSRYVNEPKFTERPAGFFQSKVAAYLDAVNAAGDKLSGKSKSVEAKAQQQKASWFTFGSNQQEKLQQTYDVERARAAKQYELAKAKLDELKNSFDKQKSPDVARQLEAAQKDFNSSLNNLKAYGRDFIDQTNKDLESAKNSWWKWGQSKSDQLQKEYDSNKAAANSKYEAAKKRLDDLTRQVQSSNPFKTKQEELDHLQAAKDDLSSSYDNLKKFGSSLIDKVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B853</accession>
    <name>G3B853_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_115813</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B853"/>
    <dbReference type="STRING" id="590646.G3B853"/>
    <dbReference type="GeneID" id="18248033"/>
    <dbReference type="KEGG" id="cten:18248033"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076155_1_0_1"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="85"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="85"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="232" mass="26111" checksum="DF290C801D36976E" modified="2011-11-16" version="1">MSEVKAARDALVASLFELSKAAQDAAAATANLYKASHEGNTGNVDSLNSLSKAVNVLVSYIDVNGGADSKKPEKKKKPEKDPNAPKKPLTMYFAYSFHIREQIRDERKANGLPPLSAIEMNAYVKERWSKLSEAEKSTWQKKYQSELKVYQKQKEIYIAEKNGIKPPLPEIPIELPKDVVVESSDSSDSSSSESEVEVEIPEKKEKKDKKKKRKHEDKEKDKSEKKKKSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B878</accession>
    <name>G3B878_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_115167</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B878"/>
    <dbReference type="STRING" id="590646.G3B878"/>
    <dbReference type="GeneID" id="18247751"/>
    <dbReference type="KEGG" id="cten:18247751"/>
    <dbReference type="eggNOG" id="ENOG502QQRF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_0_0_1"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43123:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="89"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="334" mass="38223" checksum="7ACA7315F7AA0CAC" modified="2011-11-16" version="1">MFDTTSVGVLPKEVNVDKNQGTKYDFKRDLIGYGRQGLDCQWPENRKVAVSFVLNYEEGAERSLSLGDETAEFSLSTPSKTGPLPNRAYDIETEYDYGSRAGVWRILRLFSKHENKITAYAVGKAFERNPDVANAFVRDGHEIASHAYRWIPYADVAPEVEKAYILKELEALKETTGEDAPGWYMGRLSPQSWALICEVYREMGKELPYISDYYGDDVPYWADIPAEQDLPDNEKKGLLLVPYSFDCNDYRFLNANGFRSIQGFYDHLKNAFDTLYAEGGKMMTVGLHCRIIGRPGYFQALKKFVEYVNSHEDVWVCSRSDIASHFKSKYPYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B890</accession>
    <name>G3B890_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoin permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_94604</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687885.1">
        <property type="nucleotide sequence ID" value="XM_006687822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B890"/>
    <dbReference type="GeneID" id="18250419"/>
    <dbReference type="KEGG" id="cten:18250419"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_2_1_1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="62629" checksum="59A7701C903F29D7" modified="2011-11-16" version="1">MKVFSKLRIKTVPKGPHAWYNRDLLPTPTDERTWGIYHFLFFYFTTSLTPSSYTLGSTLVSNGLLWWHGLICAVIGSFFLSIVLVFNSRAPSVYHLGFPTIVRAAAGMYGSYFFIFVRISVATIYFAVQTYFAGSLMDVLMRCIFGYKWVNIENKLSSDSGITSRGLLSFFLIWFFQLPLMFMHPRHQRHLYSVKMITTTTSLFAVFGYCVRKAGGTLGTPESLATDRVYGSDLVWGVISGINSIMGALCPILINTGDVVRYAKRPSDAAWIQSFAVLCSKVLITFLGCGTTSAAKVFLGETYWNPWDLYNGLLDHNWSAGMRTGIFFASLGMIIALVIVNVGTNCLPVGADATGMFPKYVNITRGQFLCWLVCPLLFPWKISSSGASFLAFLGSYSVMLCPIAATMIYDYFIIRRGNYHIPSFYNPDGTGVFWYNKLGVNWRAMAAWVIGCGFTISGVANSVTPGSIGIAAVRIYQLGFLLSFIVAFVAYGTLCFAFPVKNILPDDKDIKSIGFEELAQSDGFLPGESLDSIIEPTVEIIDSETIPESNSIGNEKGNFVTSSKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8M1</accession>
    <name>G3B8M1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_115214</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573</strain>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8M1"/>
    <dbReference type="STRING" id="590646.G3B8M1"/>
    <dbReference type="GeneID" id="18247771"/>
    <dbReference type="KEGG" id="cten:18247771"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029942_1_0_1"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833542" description="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" evidence="20">
        <location>
            <begin position="23"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV62649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="492" mass="55370" checksum="F88F409C7875F817" modified="2011-11-16" version="1">MFGWIKLSLLVASLAMITPNSPIKTSVAFSVIGYLITVTLIPRVGDSFIKIGLKGKDMSKAAPAHEIPESMGVVSAITYLFMMFGLIPFVFFKYLVSYSNLSNESFQSKNYLDQYNSVDDTKLFPHNKLSQYLSAIICLQGTILLGLFDDLFDIRWRHKFFLPAVASLPLLIVYYVDFSVTSIVIPTFVLNHLPFGDVLLNVINNVIKLGNHLVTYVTGLSFSTLNSDYSVPQGTPKLLDLGIFYYIYMSSISIFCPNSINILAGINGLEVGQSVVLAIIFLINDMCYLASPDVTNAAYDSHLFSVIFLLPFLGVSLGLLQFNWFPSKVFVGDTYCYFSGMVFALVGILGHFSKTLLIFFLPQILNFVYSVPQLFNLVPCPRHRLPRFSTRDGLMYPSLGDLKSPTPISKTILSVLEWFKLIKLEREDGQIVRFSNMTIINLNLVWFGPMREDHLCLLILGQQFVLGTTMVLVRHTIGPWLFGYDNLSWRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Q1</accession>
    <name>G3B8Q1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115865</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689072.1">
        <property type="nucleotide sequence ID" value="XM_006689009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Q1"/>
    <dbReference type="STRING" id="590646.G3B8Q1"/>
    <dbReference type="GeneID" id="18248060"/>
    <dbReference type="KEGG" id="cten:18248060"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="268" mass="28969" checksum="F192A325BB13F6D4" modified="2011-11-16" version="1">MSFGSKAAERISNKVVLITGASAGIGAATAKEIAVTANGNIKLILTARRKDKLQDLADELTQQFPDIKVLTVALDVSKLETIRPFVEALPQEFADIDVLVNNAGLALGRDPVGSILDEDITTMFQTNVLGLITLTQAVLPIMKAKDSGDIINLGSIAGRDPYPGGGIYCPTKASVKSFSHVLRKELISTKIRIIEIDPGNVETEFSNVRFKGDLEKAKAVYAGTEPLYAEDIAEFIVFAITRKQKTVMAETLVFSTNQASATHLYREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B964</accession>
    <name>G3B964_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115935</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689108.1">
        <property type="nucleotide sequence ID" value="XM_006689045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B964"/>
    <dbReference type="STRING" id="590646.G3B964"/>
    <dbReference type="GeneID" id="18248088"/>
    <dbReference type="KEGG" id="cten:18248088"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760753_0_0_1"/>
    <dbReference type="OrthoDB" id="19102at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="330" mass="37396" checksum="6ED92AE1D6813827" modified="2011-11-16" version="1">MSRQPTLAESVGNIPPIARFFTVSTLSVCMLISLGIIDPQQMIFHPSIYIEEFEYTKAVFTMGTWTEAVKSVLLLVFECYRCFTSFLVPAGFLDGNRMGAVLDIYFFYKFANNVEIGKFKGNFPDCLWFTLICGTSILTMTVGYYFYDPTRITRHHESMLLCITYIWARGQKNSIVNFLGIVPIKAYYLPMFTLFIKAVVHGYDGLVDSSMGIAGGYLYQCLQSSTAPIYNLFPQFYRKFYSSSIYSRNRVGTNQVSLADDFINDTVFDRGYLPAPSWVYSILKYPVDRSSKRITAFGKPIEPVRSDLKSEASATTTGSYFKGRGFRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9A4</accession>
    <name>G3B9A4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_125078</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">G-protein that, in its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled before binding another molecule of aminoacyl-tRNA. Required for mitochondrial protein biosynthesis and maintenance of mitochondrial DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9A4"/>
    <dbReference type="STRING" id="590646.G3B9A4"/>
    <dbReference type="GeneID" id="18249077"/>
    <dbReference type="KEGG" id="cten:18249077"/>
    <dbReference type="eggNOG" id="KOG0460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_1"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="35"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="427" mass="46735" checksum="822CC4EC76AAF757" modified="2011-11-16" version="1">MLSNFASIARANVRFALRASRPALTRGYALFDRSKPHVNVGTIGHVDHGKTTLTAAITKVLAQRGGADFLDYANIDRAPEERARGITISTAHVEYSTEKRHYAHVDCPGHSDYIKNMITGAAQMDGAIIVVAATDGQMPQTREHLLLARQVGIQNLVVFVNKVDTIDDPEMLELVEMEMRELLTQFGFDGDNTPVIMGSALCALEGKQPEIGEEAIMKLLDAVDEHIPTPTRDLEQPFLLPVEDVFSISGRGTVVTGRVERGSLKKGEEIEIVSYLDKPIKATVTGIEMFKKELDAAMAGDNAGILLRGVKRDDVNRGMILAKPGSVTPHTKILASLYILTAEEGGRHSPFGENYKPQLFIRTSDVTGTLRFPSGEGVDHSQQVMPGDNIEMEIELVKKTPIEVNQRFNLREGGKTVGTGLVTRIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9D7</accession>
    <name>G3B9D7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein KRE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115947</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688649.1">
        <property type="nucleotide sequence ID" value="XM_006688586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9D7"/>
    <dbReference type="GeneID" id="18248094"/>
    <dbReference type="KEGG" id="cten:18248094"/>
    <dbReference type="eggNOG" id="ENOG502SASR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156717_0_1_1"/>
    <dbReference type="OrthoDB" id="5406216at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031452">
        <property type="entry name" value="Kre1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17056">
        <property type="entry name" value="KRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442815" description="Protein KRE1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13204" checksum="63D9972D73121E0A" modified="2011-11-16" version="1">MNFTRLVLLLFSLFTTIAALADQGDGQATTNKKTTTSVWTTITTKGKTTAFQTAYFQSFMSTYSEANTDDVKSGNIGLASSADTSLGGIRTYDQTTITSPNDGHSMEAGLFSGIVGLSVIILGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9F8</accession>
    <name>G3B9F8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_131349</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9F8"/>
    <dbReference type="STRING" id="590646.G3B9F8"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041939_0_0_1"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016852">
        <property type="entry name" value="SET_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027158">
        <property type="entry name" value="Lys_MTase_YDR198C_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="44"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="446" mass="51242" checksum="EDE771DC2516D4B7" modified="2011-11-16" version="1">MESYSPTIKTLLEWINTYPTSTEKSSRGSFISSKISIKDYGDEGRGLVATSKVFNNEEIIKIPHSLLLNAHSVIRHISAYNSATKLPDHYSNIELLYDPQKTNDDISLIYSVIQYEEMLTMSSFQLVSLFLCLEAKRRSSFWRPFLDSLPTIESFQLTPLVWEVMKFKNYQKYLDLLPDQTGTHAAEVYFRFQSDFDAVKSFLSTKLNTLHKTDALAEYLDEQQYLVAWMCINSRCLYMELRESKDSSDNFTMAPYVDFINHTDTDQCSLKIDGRGFHVSTTTTYEQGNQMYLSYGPHSNSFLLCEYGFTIPSNQWNDLDVSPVIIKQMNENQIEFLKANDYYGDYTIRKGSGVSYRTEIALAVLQEPQPQNSRKLNAYIQGLSEGEHYSAGSRLLLEAILTGPVKDYENSKHLHSNGKQDQIEERILRCIGSLYEDLKDIVDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9G3</accession>
    <name>G3B9G3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_108120</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9G3"/>
    <dbReference type="STRING" id="590646.G3B9G3"/>
    <dbReference type="eggNOG" id="KOG3134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057366_0_0_1"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="307" mass="35899" checksum="DE293C32F38A4385" modified="2011-11-16" version="1">MICVECKNPNVKHAYSKYKGDYIKLDVCSVCNHVVDKYVEYDNVLLFIDLMLLKPQAYRHLCFNLTENEMTAPKIPTRTPKGHKGKKMSLEKQTWKLGQITRFLILDILFEVYLLWAYEEKKHQHTQIMNVILSQELHMQYLLFTVKVVLDHVFFNAALQLIFFQFLGWNKMHNGNIHQNQQRLYHSLVLLTDILVANSIKLLPILMLIWPYDKTLESSKIVLAISILNVIESLKTISNVGYVKIAITFGVCIVFQKVMTSTIVGLIVSQMTNFEFSELFFNTFQERANVIQSYTRMLKLPNHMEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9L6</accession>
    <name>G3B9L6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_94797</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688093.1">
        <property type="nucleotide sequence ID" value="XM_006688030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9L6"/>
    <dbReference type="GeneID" id="18250439"/>
    <dbReference type="KEGG" id="cten:18250439"/>
    <dbReference type="HOGENOM" id="CLU_466905_0_0_1"/>
    <dbReference type="OrthoDB" id="4086732at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="584" mass="65432" checksum="462AF391D03DE621" modified="2011-11-16" version="1">MNGSPANTGTAISEPVFGINSDSREVNLGQISGSSPKQLLEINRSKVHNRVLQSNNGDESSSEDSEFEDLETPKIIRNSHRNDSINNSGIFSIKSTTIKVPLNSSAKKGKQPSTPHNNKKNTKTASSPVSNRFNGSGVLKDREDSLIRENKLISDDNQFSPNLKGRSGLLKSTENSSSKIIGDHPMPSPGRTKIKRFDFEKLKEKNVSKKGDEHKPMRKEDPVIRLFQAPVVGMVNGGNNDVDEDDGEFGSSDNQEDPDKLSMKPQVDNFTIRTASPKLDKIDDIVINQANTNNIASSLETDSVLTGVLGKRSLQDGTSRVDFDLSNNKPLSHLNHTISVITERNDNISKNIKMDLDRELSSDEHEVSMDENSSALLNELNSYSFIPKFQSPAKPSAPSISAGPKSKTRLTSSRVSTPKFGTRMGRLPRVNRNQNQSPNPQVGKFTTSGSSTNHSNKQFKPEMTPIRKHYDRLENKYAKHIMNKRRNSAMEPEPEVEEESITHNRLPKPSQLNKPWPEEKWEKLNQLLKSPTLTVEDILNSDTVQDKLDISKSDLEERIKFLVKFNEFKESRNQKDSRKRRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9N1</accession>
    <name>G3B9N1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Natural resistance-associated macrophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_125282</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9N1"/>
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    <dbReference type="KEGG" id="cten:18249095"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF50">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="585" mass="64560" checksum="17A5757C69D7B2C2" modified="2011-11-16" version="1">MDPGNYSTAVAAGSVYQYKLLFSILLSNCLAIFLQILSARLGCVTGLDLATNCRIHLNHRINMLVYVMAEIAIIATDLAEVVGTAIALNILFNLPLVVGVLITIIDVLVVLMAYRPNGPLLFVRIFEMFVSVLVTATVICFGIELYQVSHDKSIDFDLGDVFKGFLPNEKVIDLSDREGGNGLFLSLAILGATVMPHSLYLGSGLVQSRLKDYDNRNGYTIPSSEGEVSDVHEIEGEGDEFPEDSIQDIRQKYAQEEEDHYRPSIHAINDTMSYTIVELVISLFTVALFVNSAILIVAGATLKKKDDKRDDEHEHDGNESDDEDEHYENADLFTIYKLLSTHLSKTAGVVFALALLFSGQSAGIVCTLAGQMVSEGFLSWTMPPVARRLITRALAILPCFMVVLMTGREGLANVLNLSQVVLSLLLPFVTAPLIMFTCSKEIMRVPITAAYEGDIETEEDFSIHTSEHDHMRYKSREPAIKLQDLRKSHPCAGFEEEEPLQISSSTQENESLIQHTNDLRSINHPEYAAGIPTNRKDPYDNKVVGYKDLSNGPLTTVGAILVWGFITALNLFLIGSLVLGYDVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9N7</accession>
    <name>G3B9N7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-22 sterol desaturase ERG5</fullName>
            <ecNumber evidence="6">1.14.19.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome P450 61</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ergosterol biosynthetic protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_115386</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="6"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9N7"/>
    <dbReference type="STRING" id="590646.G3B9N7"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="5 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="512" mass="59314" checksum="C1B7778E1B980ACA" modified="2011-11-16" version="1">MSVNATSAIGDELSVINAKFLWTSATDYFAQVSTLQWIVTTLVLLLTFEQVNYLMKKEIWPIIGPFLESLDPKFDEYKAKWDSGDLSCVAVFHKFVVIASTRELSRKILSSPKYLKPCLVDVAIKILRPSNWVFLDGQAHVDYRKSLNGLFTTKALEDYIPIQEKYMERYLSQYVEYEGARQFFPEFRELLCALSLRTFCGDYINDEQIKMIADNYFKITSALELVNFPIIIPYTKTWYGKKIADDTMKIFEKCADKAKIDIIENNRKPSSLMEKWIFSMKEAKSGDQSNEETKLLSRDFTSREISEAIFTFLFASQDASSSLACWLFQIVADRPDVAQKIREEQLKVRNNDLSARLDLDLIGQMNYTSNVVKECLRYRPPVLMVPYLAKENFPITKDYTVPKGSMIIPSFYPALHDPEVYPDPDEFIPDRWYNATDEMTKRNWLVFGYGSHACIGKNYVLTLFTGMLGKFLLYADLIHHKTELSEEIKVFATIFPKDDLILEWKKRDPLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA93</accession>
    <name>G3BA93_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114862</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688679.1">
        <property type="nucleotide sequence ID" value="XM_006688616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA93"/>
    <dbReference type="STRING" id="590646.G3BA93"/>
    <dbReference type="GeneID" id="18247612"/>
    <dbReference type="KEGG" id="cten:18247612"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="293" mass="32254" checksum="8B09A0659171F5D2" modified="2011-11-16" version="1">MLARTLAMVNPIRKAGCLIIGDEVLNGKILDTNSHVFAKFCFNELSIPVKKTIVCGDDCDDITNSLNTLIHDDCDFIVTSGGIGPTHDDITYESIAHAFGVECKRDQQTVDRMHSLRTEYLTTLTDRRLAAFYRMATFPVASDTVSVDKIYTDDSLWVPVVGINSQVYILPGVPQLFEKLLLGLKDSLKRRVDVDSRLKRFYVKTTTKESELAPFLADLQSSSNATYGAGSVKLGSYPHFAWGVNTISVIGDKHVSVEALRVIVADVVGNLGGEAREISVEEEETMTTTSPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAD0</accession>
    <name>G3BAD0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_135960</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAD0"/>
    <dbReference type="STRING" id="590646.G3BAD0"/>
    <dbReference type="MEROPS" id="C26.958"/>
    <dbReference type="GeneID" id="18249925"/>
    <dbReference type="KEGG" id="cten:18249925"/>
    <dbReference type="eggNOG" id="KOG1224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_0_0_1"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="271"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="485"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="767" mass="87115" checksum="64EB9672CF357D61" modified="2011-11-16" version="1">MILLIDSYDSFTNNLVCLIEGATNKDVVVLHNDTVSPPDYHVFLAKYINIIEYIVIGPGPGSPSNPSDVGIIDWLFDYFKQNPANCVPILGICLGFQCLCYKFGNEVEKLQNVKHGQIYNVRSLHESEKLYDGFYGKLLPSVRYHSLFVDINKMNSEIVALAVCDEIEDGQTTQILMGAKHYKLPFYGVQYHPESICSEEGANLIKSFDSIAVEYNVQNRHSELNFTQETSLLVDHLRGQINKKALVEGRYQSCESNVFVSAIELNFSEHQVTPIDICDTLVHETGETDFILLNSASTPGEWSIIGLPEAGKSEIITHSVDNPQNVKVQMFKSEDYETISLEPSKSVWAFVAQRFADNYISREVIVNKLPFSHERTFPFLGGYLGVFSYEEGCHVIIEKTGKICKDETPDLKLAFVERFLLLDHLTSKWFLMCVSSKSDHSNWCSSFANKLQELYHKRDLKAQLGLDIKDLLSEDQEVHFDLPSEEVYKRQFELCQEYLHSGDSYELCLTTPSKIHLPSTIKSWDIYKILSSKNPSPFSCFMDFDDVVLISSSPERFLSWKEEDSQKTIELRPIKGTVKNTPEMTLEGATKLLKTPKEMGENLMIVDLIRHDLHQFTKNIEVTQLMKVEEYKTVYQLVSVIKGHLETDDFHGIDILHSSLPPGSMTGAPKKRSIELLQNIEELQSTGIKGGRRGIYSGVVGYWSVTDDSDWSVVIRSIFHYKDDKENTESHKLWRIGAGGAITVLSNCNDEWEEMRLKLTSALQAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAD8</accession>
    <name>G3BAD8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein SUR2.2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SUR2.2</name>
        <name evidence="6" type="ORF">CANTEDRAFT_131473</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAD8"/>
    <dbReference type="STRING" id="590646.G3BAD8"/>
    <dbReference type="GeneID" id="18249528"/>
    <dbReference type="KEGG" id="cten:18249528"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_5_0_1"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="146"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="308" mass="36393" checksum="BB6E4BBC734F44B1" modified="2011-11-16" version="1">MDVPRGVFNDYSSFGNVTTLAEAFNNFNQLPQLSFVEKLWGTYYYYINNDLFATGLLIFINHEINYFGRCIPWMVIDNIPFFRKWKIQETKVPSNREQWECMKSVLTSHFLVEVFPIWFFHPLCAKLGIAFSVPFPAWTTIAKHLAIFFILEDAWHYWLHRGLHYGVFYKYIHKQHHRYAAPFGLAAEYAHPIEVMLLGFGTVGIPIVYCLITGNLHLFTINLWVALRLFQAIDAHSGYEFPWSLHHFLPFWAGADHHDEHHHHFIGSYASSFRWWDFFLNTEAGPIAKKKRESRMKTRAEMHQKKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBM3</accession>
    <name>G3BBM3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_94462</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBM3"/>
    <dbReference type="STRING" id="590646.G3BBM3"/>
    <dbReference type="GeneID" id="18250400"/>
    <dbReference type="KEGG" id="cten:18250400"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_7_2_1"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="291"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV61574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="588" mass="66949" checksum="2E7F9A4548A2F5A9" modified="2011-11-16" version="1">MPVTYKGLDCLADMSAEEYTHYYTQSQTEIPWASQAYYGYYTIYFGSAVVGVALFKNLYYRSRDHFYSKSQSAGIFTPLVDTLVAYSRFLGYKQTPMKLTYFTSLPPSVGSSLFLMASSLYLFLYCFVPHFWYRGCRGFGSPPLAVRAGVMATALTPFIYILAGKSNFITLVTGISYEKLNYLHQYVGVAALVLSLVHTIPFIYQAIVEGGAANLRHTWNNEAIYRNGVPPLVLLILLCSLSKAGVRKWFYEGFLHLHWMMGIAYFGTLGYHIYGSMATENYMWAALAFWFTQVFYRLFVKTCLKPNALFLRPSEAKLFKLQGSNAYQVNVKNRGIFWKPGQHVYLRFASRVLDNHPFSVCNLPKESENELKFIIIPKRGLTKSLYDKIDSCLSEKVYIDGPYGGCSRNHHTFEKVYLIASGSGVTATMSFLTDLAQKIESGENKVTKEVTFVWVVRKLEDIDWFRTELNKALECDRVNVLIYVCDRSSQKEKYLNEKETFTSESLEAAIETRSNELNVKFGRPNMENLVKSFAPSLGRRNFVCSSGSDSMKFQVSSGVSALQPLIFNKDLYASEVEEIFLHTESFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBP5</accession>
    <name>G3BBP5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_125842</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBP5"/>
    <dbReference type="eggNOG" id="ENOG502SY3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033075_0_0_1"/>
    <dbReference type="OrthoDB" id="4089215at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="405" mass="46117" checksum="D665977A1E294516" modified="2011-11-16" version="1">MPAMPDTLDPPVQRFQSLALSIPMDPSQFDYIVQFLRNLLNVDDPTTITLPDLSVHFEADASKEILPDVTFPNDIWFRDNISIRDCKIKVTMLHEINIMLTSEINKLDQPLEDMLLMYYQKLLAAYKFYELPAQQSYGSDVTNNFSVREELEDEIEDLAPDEGKSLNRTVSNQSSTTSLKTHHSFFSHSSANINTTNFSGLGNGKHTSTSSSGPYLGRRRFSSIVSNNNSNANKESKRQQALNSLLSKSYIYNKIKKHRESTSSMNSNISLPSVPYSGRNSVSTTATMNSAKSKRSSSNFTSLDNNELKHPSFPVLPSFASYTSSQRLEFQRSKQEYYLQIQRLLESVQAIIHQLQLNHKDAKAFKLMDFIKRYVFRFVVIDASELVLTYGEIEAYRLYSRLNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBT0</accession>
    <name>G3BBT0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_125877</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBT0"/>
    <dbReference type="STRING" id="590646.G3BBT0"/>
    <dbReference type="GeneID" id="18249136"/>
    <dbReference type="KEGG" id="cten:18249136"/>
    <dbReference type="eggNOG" id="KOG3271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_1_0_1"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="82"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="154" mass="16794" checksum="08BD0C20F8876BCD" modified="2011-11-16" version="1">MSDEQFATASADAAQTFPMQCSSLRKNGHVVIKSRPCKIVDMSTSKTGKHGHAKVHLVAIDIFTGKKLEDLSPSTHNMEVPNVTREEFQLIDIDDGFLSLMSPDGSLKDDVKVPEGEIGSKLQEEFDEGKDLLVTILMAMGEEAAISYKEAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBW6</accession>
    <name>G3BBW6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_131964</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689312.1">
        <property type="nucleotide sequence ID" value="XM_006689249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBW6"/>
    <dbReference type="STRING" id="590646.G3BBW6"/>
    <dbReference type="GeneID" id="18249579"/>
    <dbReference type="KEGG" id="cten:18249579"/>
    <dbReference type="eggNOG" id="ENOG502QUQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026011_0_0_1"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="206"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="321"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="386" mass="44906" checksum="1ED416BD3A634C53" modified="2011-11-16" version="1">MKTSEKLRILGLEYPDANKEVLRELLVACDDSLVQMRLILDQSFQRVKNATSPQYQSSVDSMLGSSSKKRKVDPHAPPRDSRSKVVMLHTEDQVREALHPYVSLHRNFLPREDADKVLVALMNNKHRYNAQQFYLFDQVCKTKSRSAFYYVPEDFVIETARYNGIIGELIPFDESLTAAAKLMNKYVNERVIPHYKRLEFQQPKYSISGCVVNYFPQLSDDLGWHSDRLQSMGPQNYIGSISFGSTREFRLRRHSNPSVIYSIHIPHNGMLLMHPGCQELFKHCVNSIKVPLQLHPICGVERYSVTFRDYPEEFTKHVPKCKCGIPMVLRRSFKTAADKNFGKYYWSCENTYQNKDCKEFHWADFTNHKNKMRSQNDASVSQWKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBY4</accession>
    <name>G3BBY4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_131976</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBY4"/>
    <dbReference type="STRING" id="590646.G3BBY4"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF6">
        <property type="entry name" value="MAP KINASE KINASE MKK1_SSP32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="145"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="434" mass="48290" checksum="5476030B3557597E" modified="2011-11-16" version="1">MSNSGPIFNIPTRGTKPSTKLPSLTISSEPASGGDAAVDVNGGEDHKKPRRKPPPIDFSRINGSHSFKDMSPAPSHDSGDVDTSDGSTSTSAKAYGTTEGSSTSRSLNQSSSSVSTPANLIPGPEKDLSELMPDDWQILANSDQIVELNKLGEGNGGSVSKCRLRNGNKIFAMKLINTDSNPDIQKQIVRELQYNRLVSSENIVKYYGTFLIENQSMIGITMEYMGGKSLDAIYKRVIEIDPSNRVNEKVMGKIAESILKGLNYLHQQKIIHRDIKPSNILLDFQGNIKLCDFGVSGEVVNSLATTFVGTQYYMAPERIMGKPYTVNCDIWSLGLTLLEVSTGKFPFTNVDSLNTNLGPIELLQLILEYEPKLEDIPQENIFWSDSFKNFIHYCLIKNTEERPSPRQMLQHPWIISQQTVKVRMDKFVQQLWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBZ4</accession>
    <name>G3BBZ4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spo7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_127017</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBZ4"/>
    <dbReference type="STRING" id="590646.G3BBZ4"/>
    <dbReference type="GeneID" id="18249210"/>
    <dbReference type="KEGG" id="cten:18249210"/>
    <dbReference type="eggNOG" id="ENOG502QTI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030111_0_0_1"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="400" mass="45301" checksum="C7B126C9B6057511" modified="2011-11-16" version="1">MNLTPYSSQQNDNDEYVMYSDSEIGSQNSLDLPIPLKSSSVDGMDDRDSSPSRSAVRRIKSASSKRRTSPRRDSGDSGTPSPKQKKKIRRKSNKSEGSEKSHPVGGGYASAPGTGKIFRNLLILEESLRDQVAQQRGLRRKYLTFMAILCAVITSIAHHLYFSNYETSSPFRVVLTFVLLALMITLLLYYLSGEYQKTIVLPRKFLSSTNKGLRQLNVRLVKIKTPLIDLLSDLIREFSLFVIMTILNLIHKFDPSLKHNKDSKIEVFFVSCQSQCQPRVGIADVKLVLNARVFNTDIREGWELYRSEFWIREGVRRRNNLMSFVTGNNQDESILDKEKLLNRDRRERRDRKKSNTGAPVSTGAGTGTSTPTSNKLNDQNLRALSIKLHEMDDSSPSLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC08</accession>
    <name>G3BC08_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_132443</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC08"/>
    <dbReference type="GeneID" id="18249624"/>
    <dbReference type="KEGG" id="cten:18249624"/>
    <dbReference type="eggNOG" id="ENOG502QSZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_1_0_1"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="41"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="469" mass="50304" checksum="FCD522A1652B3006" modified="2011-11-16" version="1">MASSIVPTSTFASTFASTIPSQTPPERPLMTSRFPQRNLWRVTAICLWGVTAGFSDATPGAILPYIESDYGLTYTTVSLIWISNAMGFILVACLSHQIQRVLGKRMSLVMGTASSVIMYATVSTGTVFPAIVAAFFVGGVGQASVSAQANVFLARLDKSSKYLAAYHGCYGIGATISPLIATVIVSAGVTWHYFYLIVLGMMMANGVMFVFAFKGADEDLAPWDHDVEPSVGPTESPTDEQGVGLVDLGPSAISQPAAKTSSSHSVFMEAVKFPITWMLAFFVLFYQGSEVSLAGWIVTFLLDYRHGSASVGYVASGFWAGLTIGRLVLTRPLHKYVGISRSIIIASLLAIVFVALTWAIPNVIVAGVIVSISGIFVGPIFPLMIAASVDYLPRKIQVVSLTITTAFGSSGGALFPFIIGIMSQRFGPFIVLPGFIILHSMMLGLWLCFPRKEPVLGLGMERLRSLLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC68</accession>
    <name>G3BC68_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116156</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC68"/>
    <dbReference type="STRING" id="590646.G3BC68"/>
    <dbReference type="GeneID" id="18248190"/>
    <dbReference type="KEGG" id="cten:18248190"/>
    <dbReference type="eggNOG" id="ENOG502S45I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137479_0_2_1"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="108" mass="11830" checksum="51E27C6BEFC69B54" modified="2011-11-16" version="1">MVSLNCIADVCIVPIGTGSASVSDEVTLITKFLRENPEGLTVTLHSAGTTIEGNWDVVMGKIGQMHELLHHHGVVRIQSDIRVGTRTDKSQKSIDKVRIVEEKLKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC80</accession>
    <name>G3BC80_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_99658</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689352.1">
        <property type="nucleotide sequence ID" value="XM_006689289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC80"/>
    <dbReference type="STRING" id="590646.G3BC80"/>
    <dbReference type="GeneID" id="18250872"/>
    <dbReference type="KEGG" id="cten:18250872"/>
    <dbReference type="eggNOG" id="KOG3274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052828_3_0_1"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="205" mass="23243" checksum="CE2D30057DDFA3DF" modified="2011-11-16" version="1">MSKALCLYAFDTLYSELKHSKPLALASIVSEVHEAPDSFPNKAPLFVTWDKDDNLRGCIGTFAAQPIERGVKRFALTAALEDPRFPSISLAELPHLSCDVTLLDNFTPISDALSWKVGTHGLKLSFEYDGRYYSGTFLPSVAEEQQWDQLTTLWYLLRKADYNSVSKSNTLKFYSEGLSQGWMELETYEGLKHTLGYDEYKKFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCA1</accession>
    <name>G3BCA1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_132007</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCA1"/>
    <dbReference type="STRING" id="590646.G3BCA1"/>
    <dbReference type="eggNOG" id="KOG4620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154777_1_1_1"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="77" mass="9365" checksum="06CD2D606A9F1E21" modified="2011-11-16" version="1">MKLSGLQKQVIHLYRSCVRMAYKKPVEYQPHWRKFTRDEFDKHQHIPKKSFAAVEHLIRAGTRRLEMYSNDQIKDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCJ7</accession>
    <name>G3BCJ7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_99688</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCJ7"/>
    <dbReference type="GeneID" id="18250873"/>
    <dbReference type="KEGG" id="cten:18250873"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="509" mass="56543" checksum="0DC9DDD1F39AF7EE" modified="2011-11-16" version="1">MTELVKEKQSPPTDVQSVESLKEIQFNGKEIKLDDGDEIIKLGLAHEEVTMTRERERQLVHKIDLYMLPLMCMVYCFQFMDKLSNSFASILGLRTDLHMVGQEYSWTGSAFYLGYMVFELPASMLLHRFPVAKTVGTFIIVWGVVLALHATPNNAAGFLALRTILGALESSVTPAFTFITSQWYTIDQTFLRITIWFAFNGLGNIIGSLTAYGLAVHSDSLSLAPWKYVFIITGILTVALGVAVLAHLPDSPATAWFLTDEDKMLVVHRNRKNHQGFGNKHLKKSQVIEALTDYKTWLLFAFVLLGNVPNGGITNFGSIVLTEQLGYTVNQTLLYQTISGAVELVGCILIASLSHFYNSRLVWGIISQCIGSAGVLMLCLGSEKHMRFAGYNMNFVSPVSFVCVLSCVASNVLGTTKKYTVNVIVLIGYCVGNLSGSAVFKASETPVYGTAKKSLAVCSALQLVMLIVIWVAYYTENKIRDRKPEPEKIENIEFLDLTDGQNPFFRYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCL4</accession>
    <name>G3BCL4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_111303</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689408.1">
        <property type="nucleotide sequence ID" value="XM_006689345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCL4"/>
    <dbReference type="GeneID" id="18246265"/>
    <dbReference type="KEGG" id="cten:18246265"/>
    <dbReference type="eggNOG" id="ENOG502S5A2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136352_2_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="77" mass="8402" checksum="BDD2563B33F2E5FE" modified="2011-11-16" version="1">MIATRSYSTPATPRRIGSFRGGLVGFLLGVVATGAGSYYYLLDQYRIANNVVVADVVALQNSISNLEKHIKLLEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCT4</accession>
    <name>G3BCT4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP synthase subunit beta</fullName>
            <ecNumber evidence="15">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_128594</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="15"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCT4"/>
    <dbReference type="STRING" id="590646.G3BCT4"/>
    <dbReference type="GeneID" id="18249321"/>
    <dbReference type="KEGG" id="cten:18249321"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_1"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="176"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV60879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="505" mass="54076" checksum="0D46BADA38534B0B" modified="2011-11-16" version="1">MVLPRLFNNTSKNLFNTATRGLKVNLTRNLASAAPAVGKVRAVIGAVVDVHFDDGNLPAIFNALTLKNGEQKLVLEVAQHLGENTVRTIAMDGTEGLVRGTTVTDTGSPISVPVGRGTLGRIINVVGEPIDERGPIEATQRNPIHADPPSFVEQSTAAEVLETGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELISNIAKAHGGFSVFTGVGERTREGNDLYREMIETGVINLDGDSKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTTKKGSVTSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKSRLLDVAVVGQEHYDVASNVQQTLQAYKSLQDIIAILGMDELSEADKLTVERARKIQRFLSQPFAVAEVFTGIPGRLVRLQETIKSFKEVLEGKYDHLPENAFYMVGGIEDVIAKAEKLAAEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDE2</accession>
    <name>G3BDE2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Receptor L-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_117002</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDE2"/>
    <dbReference type="STRING" id="590646.G3BDE2"/>
    <dbReference type="GeneID" id="18248536"/>
    <dbReference type="KEGG" id="cten:18248536"/>
    <dbReference type="eggNOG" id="ENOG502QUZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035846_0_0_1"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833550" description="Receptor L-domain domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor L-domain" evidence="10">
        <location>
            <begin position="44"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="419" mass="44091" checksum="DC177C01ECFA7D63" modified="2011-11-16" version="1">MLMNTLMPLAVVLAGVTAASSSNSCSFDDVTMTAAASVSQLASCPTLEGTLEITGNDLGSLSFNSVEEISGDIRIFNSSSITDVGFTQLSKISGSLEIDALTQLHVIDFSKLGEISDLSLISLPSLSTINLNTGVSKLNNLQISDTALSSLQGLITNVNTLGELDVNNNKNITSIDLGNLQTVKENLILSFNGDSCEINLDSLIWSSNLTIQDAGSISASELSAVNGSLIFGYNKFEKFELPVNKIGGALQIFANDDMTEFSLDNLTAVGGELRIFNNTELDNMAFQSLETVKGAVNINGSFSNFTMPELEEVDGDFTVQSDNDDFSCKSFKKLKSDNKIEGHNFKCIAPAKNTSKSGSASSGSLETETFEGSSSSGSSESDDDDDNSTSSSSKDSSASTLIGSGLVAIILTTVFSALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDH1</accession>
    <name>G3BDH1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_116348</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573</strain>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDH1"/>
    <dbReference type="STRING" id="590646.G3BDH1"/>
    <dbReference type="GeneID" id="18248259"/>
    <dbReference type="KEGG" id="cten:18248259"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000080">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV61082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="457" mass="51228" checksum="FF65DA0935EFC94F" modified="2011-11-16" version="1">MSNGTSNIVDDVLFHNKNLARVISLNRPGKLNSLNTSMVSKIYPRLVEYAKSDINNMIILDSTSPKGLCAGGDVAEAAKEILNDNSDYAVNFFKGEYNLNFLIGTYPKPFIALMDGITMGGGVGLSVHAPFRISTDTTKLAMPEMDIGFFPDVGTTFFLPRVDDKVGYYVALTGTVLSGLDAYMLGFATHYVPRDRLGSLVNRLSNLQPPNQTNLSVSNQKEYYQQINDIINEFTDTKLPKDYNYPFSTEQLIVIKEAFSQPTFDDVLKYLVDSSSQFAKETLEKLLAKSPTSLRVGFELMNQGAKNSLRKQLELELITAANIMTLNPEINDFVKGVKHKLIDKIKEPSLPEWSPVTDAVKLMTSSIEVGKLEKPLIHSVFNIDYVHYPYNFGVPKNNQIKSFINGTDTKRSYLPTVKEVYSHFKSDKLGTELKLQSTLELHGDLQKYQSKYVSWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDJ0</accession>
    <name>G3BDJ0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral peroxisomal membrane peroxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116361</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDJ0"/>
    <dbReference type="STRING" id="590646.G3BDJ0"/>
    <dbReference type="GeneID" id="18248266"/>
    <dbReference type="KEGG" id="cten:18248266"/>
    <dbReference type="eggNOG" id="ENOG502S05F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016397_0_0_1"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="6">
        <location>
            <begin position="253"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="376" mass="44349" checksum="02F646DA80C20E13" modified="2011-11-16" version="1">MSETDIIYAPFQPSDTRLLTGSNNNQLLVDNPILSSILAKIFPYLLIADNALEIITWTNEDPYTNFLFIIIYSIVIMYWNSISLVILPIIMALVFSYMIWIVNSTIFDIKYNEKPTIDEILHTLHNITVRFEMLLKPIKKSDFKAHNFIQMFVMTVLLTPVHLLLINYALSPKKFLWLTGLFVLSYHSPWSYSLRRLLWRSVYVRILVFYLTGLDIKLNMESKSKPINSKSMEHALSDLKVLNKSVESPTRLKQTILFEVLENERRWIGIGWSKLLLPSERSNYCFPHTLIQTVELSQFSPPVFNDDLYSYSWEWLDQKWSIDKEFSKNKNNGWKFFDNSWENGDFIDGFSKFTRSRMWTRRAVLCIDKRTKVNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDL6</accession>
    <name>G3BDL6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136811</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDL6"/>
    <dbReference type="STRING" id="590646.G3BDL6"/>
    <dbReference type="GeneID" id="18250006"/>
    <dbReference type="KEGG" id="cten:18250006"/>
    <dbReference type="eggNOG" id="KOG1293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320777_0_0_1"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="904" mass="105015" checksum="7BC0B0311A0009A0" modified="2011-11-16" version="1">MTMDINQLRISIIGNIDVKYKLANDERFIKEIVTELSKSLSTPENLIDGLTVIKFLAKFDHKVLQYDAFKQLNSILIEIIDQFTVYMIYHNKNKSVFELTKSNYEAVSLCIELLNILSIKQPSFKLSRFVLVLLEINYESSLTLPQSYTTSLITQCVDLIPIISNPQLEPLLITKLISRINFEISSTKPLSLKFIYKLVLNLNYILSYESIHKYNLELLDSTKLGLSNLIKFDNELLNLNIINLLFLFEKDLQPKNYQVQAYVSYDESVNYVNKLIELIEINQYSINPFKTLSNLIIKNDNLVSELIKFKIDLKLINYLKVNLKTFKLNKLIEINLSDILLLISLLTHNQEEFRVRFVNKFNFKHLLNKLCIDYRTFLIRFAKKASNNELSPNDTLFKFINHKIFTNCFNMIRSLSRSIILLRTFFIDLNIVDILIDILALLEGLRIKSENKSIVLSIFANLILDFSSFRYNLINNEKFLNTLLKVNENNQAIDEGDAIYKEQLNLIFLQILKNLMYNENEENKIKLIESHFSLTLLLKFIRYDRTEDGTELHSLRLKQKLASFDIVRNLSSNSNYFNSHLSEFFSSHLDMSWYHLLTLNIVNLSNFDRNLTRLTHDNLLKLIHNSDYVNLILSINYIENHKILTINDLHLNKNFLGLWLVFLNLSPFNKTDINASKAQMFKFYSNLNAIKMSILWILLNLTWQDKKFDIILFNDSTELTLETSDDTDLIGDFKEHIFNGNSTSAPSETVNLSDIVTRVTFLKDFGFVSSVKRLKNSLTTQSIMAHSKEDGFMINDLIEKTSSVLHQVDCVLNGKPNRPSHIQDLKRYSAYGAPEPPKFIHTTFHPVNRGGEGFGYDSDDYVDAEDIQVQDAEEDEPADHNETRDEDEDDDVDGVDDVDDLWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDX0</accession>
    <name>G3BDX0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116454</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689616.1">
        <property type="nucleotide sequence ID" value="XM_006689553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDX0"/>
    <dbReference type="STRING" id="590646.G3BDX0"/>
    <dbReference type="GeneID" id="18248314"/>
    <dbReference type="KEGG" id="cten:18248314"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="428" mass="47732" checksum="BD8FC5165A3FFE96" modified="2011-11-16" version="1">MSDDYDYDVLVVGCGVFGLSTCLELSKQGHKVLGLDAYPVPSELSAAKDYNKIIRVEYPDELSAKLAVEALRCWENDELYKPYFVKSGRLTLTPGDSTSIRSQYENKSLEILAKLGVTQSFEKLTTPKQVADTISHFKKNNLPAKFNSTYNADCGTGLSADALKAVYERATTSGAQFVFGDDGRAVSIKSNEVRVKSGKIFTAKKIVVTAGASTGLIIPLDNQTKVFGTFVTHIKLTDAEYEKYKDMPIFFSAEYGYFFPPDKVDHVIKIGVTTCDAWAEIDHPFEAGNKLRAPRYTVDHPNETFPLGHEKDIKVLLNLVVPELADHELVDSKVCWIADSCDSYFLIDECPYYKDVIVATGDSSHAFKFLPTIGKYISQKVNGALPADLSETWKWRSNPSFDNGANTKSRFPRPHYNLEEIKFIKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE43</accession>
    <name>G3BE43_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_111011</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE43"/>
    <dbReference type="STRING" id="590646.G3BE43"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_10_1_1"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="577"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="766" mass="85072" checksum="0E57FA5217C79AC1" modified="2011-11-16" version="1">MSQDSRPGTSSTDGSENRLVSPSPSIRKISHQRVNPHENQTSFSKIPGGMGISGPSQHPSEYRPVTDEDSDSMSWGELLPYYLPILSWVNHYSLPFFLGDLLGGLSLVFFQLPLSISYATSLAHVPVICGLMSLGVAPLIYLIFGSVPQMITGPESAISLIVGQAVEPILHHNKTDINPVDLVVAMTFISGATLLGFGLGRFGFLDNVLSGSLLKGFISGVGIVMAINSLVSMLGLTKLMNLISNDPTDMDIHSPFDKFMFLIHHYDRYEPLTFKISFASFTFLMSVSIFKSYCSKRNFRFSDKLIYIPEILIMVIITSCLCYKFDWHANGIEVVGSVSQEGGTFSIYNPLSINQFRLMKKVGTSGFLCAMLGFFESTTASKSLGTTFNLPISSNRELVALGFINVVGSMFGALPAFGGYGRSKINAISAKTTFSGALMGIFTIFTIAFLSEGLYYIPKCILSVITAKIGLSLMDEAPYELMFHWRSRGYNELITFFVTVVTTIFFSMEAGIAVGLVYSLIRVIKNSTLSRIQILGRIPGTNTFVDADINDRLLKMDRKLGKSQLNLFTDDYFTSVNMNVLEEIEGCLIVKIPEPLTFTNTNDLRTRLKRVELYGSTKAHPAMKRSRDESMTKYVIFDLRGMSELDSSAAQILKELIINYQNRKIISLFVRVAKNLQVRERLFRTGIISLLIENLDALGYYKAKQEVLQKKPKDNSSDFLFEQETASGIANLVEAKDVPFFEHISDALKVIDYYESSNQVGEYSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE48</accession>
    <name>G3BE48_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116507</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE48"/>
    <dbReference type="eggNOG" id="KOG3017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035730_3_2_1"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05384">
        <property type="entry name" value="CAP_PRY1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000012">
        <property type="entry name" value="Secreted protein PRY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442855" evidence="5">
        <location>
            <begin position="19"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="6">
        <location>
            <begin position="139"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="273" mass="28521" checksum="E3D5BD04403632B5" modified="2011-11-16" version="1">MQLFNLATCLSILAVIEAATLVVTQTEIATVILENGVLSTILPSSSANSSSTLNSTSQSSTIINTPSLDAEIKPATVSPITYTAPSQAPTTLLTVSSYVAPVTVPTSTTPAAVTTQAATTEAAATTSSSSNIGGSVDQDFASSILNAHNEKRAAHGVGSLTWDDNLYQYAAAYASKYDCSGTLTHSGGQYGENLAVGYSDGVSALEAWYDEGSNYDYSSASSFDHFTQVIWKSTTKLGCAKKDCTAENWGQYVICSYDPAGNYIGEGKENLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEF6</accession>
    <name>G3BEF6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_109838</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690393.1">
        <property type="nucleotide sequence ID" value="XM_006690330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEF6"/>
    <dbReference type="STRING" id="590646.G3BEF6"/>
    <dbReference type="GeneID" id="18246146"/>
    <dbReference type="KEGG" id="cten:18246146"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="580" mass="63624" checksum="5CD6295A0D7B6CB0" modified="2011-11-16" version="1">MKDEIKNIHSNEHTHLGPELCSSDDGNSTAPADPPAATTPDKERDLSDRLGDAHLNILPRKKLITIMFIMAFNVFTAFVDQTAVTIALPTLAKELNAEKTINWAGTASLLANCVCQVLFGRLADIFGRKGVLLYSLAFLGIADLACGFAQTGVQFYIFRALAGVGTGGIQAMTMVLISDIVTLKQRGNYQGILGANVGLGNACGPFLMSAFVSSSSWRNFYHMLPGLVAIQMATTYFFVEDRKKHLDSVLTKKEKFMKVDYIGMFFSTAGLTLILVPLNGGGSTYSWNSVLVIVMFVVGGLCSVAFIVVEWKIPKLPMIPLNLFQSTSLNLIFSSNFFYGLIYFSFQYYLPYYFQIVLGKTEMQSAVLQVGMVLIQALMSTIAGQIISRSGHYKYVICGGYGSWLLGLGLLMLFDINTPDGEIVGILLVIGCGVGWTFQPSVVAAQAQSRKADRAVVISTRNVVRCLGGAIGTAVASLIVTNTVMAEINKAFSNPDNYDNISVGYLTYLKEHIYNKISVQGLTDGQVTVVKKMYMKAIRNYFYMTIPLMGFCFISAFFVKDRGLRCIDEVIEKEEKESEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEK6</accession>
    <name>G3BEK6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_116647</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEK6"/>
    <dbReference type="STRING" id="590646.G3BEK6"/>
    <dbReference type="GeneID" id="18248385"/>
    <dbReference type="KEGG" id="cten:18248385"/>
    <dbReference type="eggNOG" id="ENOG502S4R3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110314_0_0_1"/>
    <dbReference type="OrthoDB" id="4094515at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059107">
        <property type="entry name" value="Mso1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14477">
        <property type="entry name" value="Mso1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Mso1 membrane-polarising" evidence="3">
        <location>
            <begin position="138"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="218" mass="23744" checksum="B31B65EB99194578" modified="2011-11-16" version="1">MNQYQNRSAEEQKTFLSKIKDNYSAKFGNLSLTSSIQKASSYVDKDGNSETDTLIHKAFVKYFDSQNQAYPEWLGVPAAPARSSARAGPPSGYTNVSSSQYKPVYSNYNTPQPPSQQQPQAQSQYAEPAPAAQSAYKPRSSSRLQDMYNKSRQQHVPGGGYNTVNQAPARTNSSTSGARLRERMMNSTSMTGMNNVISEGNNGGSGGSNGSKATWGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEN5</accession>
    <name>G3BEN5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115966</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEN5"/>
    <dbReference type="STRING" id="590646.G3BEN5"/>
    <dbReference type="eggNOG" id="ENOG502S4DF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043312_2_0_1"/>
    <dbReference type="OrthoDB" id="5391991at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV59937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="274" mass="29737" checksum="45220F730B0742CD" modified="2011-11-16" version="1">MSFQNKNLFHLLGNDVEDEEPSLAPRELVKNNTSSKKKDEAPKADPSKAKKKKPVTGNEGAIKEQLNNKEVPGPSSTPTSHYKKSFDRHATRTHKGGQRKPRTDPKDGEATLEDELDGEQDAEEEEAAAEVVDQTPKKSLEDYMAELKLAQATLDGQKAARTANEGAEGKWTAEELLVKQQEEYVPASVEKKIKQKAAKGKKFLEFDATFDAPSAPRPASSTRGSPRGGRGAARGATRGARGASRGARGDSKPATSRRTDSKVALDDDKKFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3BET3</accession>
    <name>G3BET3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_132311</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BET3"/>
    <dbReference type="STRING" id="590646.G3BET3"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023743_0_0_1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="151"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="151"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="504" mass="56805" checksum="A7CC71533ADB9453" modified="2011-11-16" version="1">MSVDGFRIPLQDSKIEINTPLPMKSIHNQKITTPPGSVSGIKKQVSDANSSLIETPIKNYDNGEGIDGLNLSKHLLLSPAFSSPQNHLKYNSNASSQYPYLRPSQSQAYNSSPPPVPSTNLSSFDDEFDQEKPKKKKKKDKKAFDIQSNDKPPYSYATLIGMSILSHPDKRLTLSSIYQWISETFKYYKKEDVGWQNSIRHNLSLNKAFIKGEKSKDGKGHFWCIEAGCEDQFLKSRNNKKGSYQEIMEQIYNKPQGLARSRKRTIGSIPSSPNYYDSNEASFAGMNEAADYHRKNDNHFHEEMDEDDVGFHKRQKVSNRSDLGAPFDQNWSLSPPPAKTNNGTHFDLMNTPKVIISHSPNKPLVAGKNLTFTSSFSCNSNLELSPIRPNETGPLLQPLTPGKVYKAGAINHHIPNIQYQSSHTPKATIKTPIRILKTPQTSAKKLWNSPGYLDDFYYSPLITSQSALHSYDDDDMILRAFESPANSRKIVDDYGIYDNWDGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFC3</accession>
    <name>G3BFC3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_131909</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFC3"/>
    <dbReference type="STRING" id="590646.G3BFC3"/>
    <dbReference type="eggNOG" id="ENOG502QSCI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002075_1_0_1"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="63"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1261" mass="144272" checksum="F482021A159727D7" modified="2011-11-16" version="1">MMGAGTPASTISTKIKEDCYNKFIKDNGQTVRESTYQAHLSVKEYSQYSANPPPANVPDSQLGSVKERILVLCTKYSGRVLLQKGKLNESKNQYQIGRTWDLEELKAITKAGADGLILSLNKDYYWKYEEGPDRIERFVKFLTRSYGMYMGKYPVLNGWSIEEFDLPLTAVKKPFGVNASTQEVSYPQPDAQLMKSKSLKRKNLPNPVLPSLPQPRQTSQSSFQQTGQSNVSVEDLYKDIDFTANGKLPMKPMKVITRSADISQTSLPESTGTSREYLNQTSDSHYPQSSMNHPYQSVAPARSETEFTNDSQSFIFGPEDIAEELPKQRTSQRANSSAQSQQSGSRKVSEQFETNAALHMQLEERLRQPNGIFDSSQDYGIEESNFTDEEELGKPINAVILEEESLKDVSQSSNIDSRDMGAIDSSIQEIEDFMDSQLNFGSRNKSISKSIMSLRAPATQNNVIVIDSSEADVSDDRSFLATENDTSNTHDYTEFETETDAEADLNVSKKTGTLQQDRDPEIEEILDELQWEIEDDCNTLIKKLTGELNKLKYNNVKELVNLDFSGDSKKEDLKTSLDEIENINHIFRKMEINFKILAPEISTIENNSQGLQVKSVNKKSLFKDLKSILDKVSMSARDLSAIENFKEFDRINMLQTVESQILNLYNALETIRQDQTRDIDDSDRLDSMNALKQYLSNYGSVSNRFIKHFLDFFKKQFSFRMDQLNSLDRIYPKSLYVELNSLTIYSTFTFFTKEISPGDFNDLKLFVTSRLADFLEKLLKMRIKTIKFSDSHAKFDTANASVSSRLESSELGSLKKSRTLRLASRRDKLIGKLGFSEEDHLPKVSAPSSPKVETPASEANYSNSLVTSTGIEDTKTIVDIVSDAKEISIILTNFIGQVFHYESNIFNLNDFMKFNPLEKRVENLDKAPIEVQNNYTNDLVSVLNSIFGNYNNLFTKKIVPIEYNIPVILLYLESLSNESQKENLDYFVFNFLKKVLDKYRHSWTKFVKGHIDMVNKSSVSSKSGILPCIKNVNQFFHLTESALDHRSRVYGDLDDSDTKTILAQSYKEITEACIHLFVKDDPLLKNTEFDEKERNHRNVSIMQNIFSLSEQLVLFNNERTNKVKSKLDTVFKKVQETYFSKLLNQNIGKIVEFVNNFEALTDNNVKAKKYNKKTVKTILSGYTTKDLGNRAGEIRRKLEKHFISGNNMFEKDLLDRLWSDMEKQFIMYFFRLDNILSRNYSDIEYHISKQEIHSIFRSLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFG6</accession>
    <name>G3BFG6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_116746</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFG6"/>
    <dbReference type="STRING" id="590646.G3BFG6"/>
    <dbReference type="GeneID" id="18248428"/>
    <dbReference type="KEGG" id="cten:18248428"/>
    <dbReference type="eggNOG" id="KOG3303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="65"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="9">
        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="219" mass="25082" checksum="07CF65C50E6F63BE" modified="2011-11-16" version="1">MFGDQANKLVLDAHRTSNLPEITLYQSDLVDDIVKETNDLGRDVDYITEQQRTNPEGTSAEQIVALECQLFVARLSMRRNKRCLLAHQKLRADKMNEFAWLNIDPSDSNSTPQPSLTKTGALGSNYTTRMILDNLSNQEQEYFKQYSQLLVDMKSKYVDIDLSGDLEPPTSIFIDVRVLKDGGEVQTEYGVFNLIKDSQFYVRKSDVERLIQQGYLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFH7</accession>
    <name>G3BFH7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">m7GpppX diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Decapping scavenger enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Scavenger mRNA-decapping enzyme DcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_116751</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65388"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58285"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="EC" id="3.6.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.59" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690440.1">
        <property type="nucleotide sequence ID" value="XM_006690377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFH7"/>
    <dbReference type="STRING" id="590646.G3BFH7"/>
    <dbReference type="GeneID" id="18248432"/>
    <dbReference type="KEGG" id="cten:18248432"/>
    <dbReference type="eggNOG" id="KOG3969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041045_1_0_1"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140932">
        <property type="term" value="F:5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000006">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV61226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="304" mass="34929" checksum="F52284FAE9BF29F9" modified="2011-11-16" version="1">MSDISSLISGFQFKQVLQSDPQTKNIALLGTINNENAIVSLEKSHFFISNDTVDINQTVQELQLIQNNDVYYWSAASLVQKLPDLPAAKLNLIYPATETHIQKLSTQVSHYVLETPQMYQEFAVSYIESMKGDRIKWVYNILFEGKESETFVYHDKDPETGFVLLPDMKWDRVSMDSLYLCCIVNRTDISSVRDLNASHASYLQALRNKILEVTCEKYNIQPDQLRLFIHYHPSYYHFHIHCVTIKHPGLGNGINVGKAILLDDVIENIQLASDYYQKKTIGFILGENHGLWNVDGYRNAHLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFK3</accession>
    <name>G3BFK3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_131921</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFK3"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="57"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="543" mass="61843" checksum="67BF577728EFF4C8" modified="2011-11-16" version="1">MLTDSDIVPGTVHLVDIEGTLHVKKDEHGNDKVILRPPPSKNINDPLRWSRMKKFKQFFMLFWLAVFLALAVAWSSPIWLIWTVDLNCTIQDLNNAMALTFLFLGLGCLFLQPTAMKLGRRFVYLMCCVLMMIAQIIGSQATSVHQIYGVFIITGFAAAPCDSLVEISTTDVFFQHERASFLALFILALYFGNYLGPAISGYIVDRLSWKWSYYLQLIMFGGTFIVLLFFMEDTTFRRREGDEEFEEEILGQIKSRETIGVEEEKDKTIHQVNEAASSSDSPDDDFSIDHSIPERGYWQKMKIIQTEYNDKRSWFKIWARPFLMLSFPAILWGGLIYGAQMMWLSLISTSQASLYGAPPYSFSSGTIGLFNFSPLVGNFIGMLYGGKFVDWLTIKLAERNKGIMEPEFRLYAMIVPTILNACGLLTYGLANANGDPWPVSVIIGIGFLGFSMSSTGAICLTYAIDSYHEMASEGMVMMLFIRNMIGMTFTFVFQYWLDRCGLVLLTWLLFMMALVINGSFVLLIIYGKRIRMYTKDRYLNAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFQ7</accession>
    <name>G3BFQ7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1776-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_100064</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFQ7"/>
    <dbReference type="STRING" id="590646.G3BFQ7"/>
    <dbReference type="GeneID" id="18245357"/>
    <dbReference type="KEGG" id="cten:18245357"/>
    <dbReference type="eggNOG" id="ENOG502QWSS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022136_0_0_1"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="414" mass="46794" checksum="886871A21324F2CF" modified="2011-11-16" version="1">MQVVHSEPVQATLDTLGYFYGRASDFLSSQAEALQQIDFKQYDLRSDSTRNQFTRKSSLLDVIYKHKGKIGLLTVGIGIGAFYYYNQFQPAHKLGLKPAYNMPPKPKRRVPKLANGARQDVVLVVGSPTEPLTRLIALDFERRGFIVYLTILDEKDLKYIESNPITNDINYLNLTNSYSFESQLNKFNHLLQVPVVPFAGAEAHNLKLRAVVFTPNLYYPIGPIENITVASWTKITDRLSVYLKLFSSGLIQLIRLQESKTILITPSITSALNLPYHSPESLLQNALQGLFTTLSREIRQHNLQVTQVRLGNISVSSNSNTSLKTSSIINAEIKSWNEDIKLLYSRSFTKSQFRSSPIKSSGKGTNLRDLYHVLFDLIYPKKTNPQVVYCGTGSQIYDWISSLLPVSFVSWILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFT2</accession>
    <name>G3BFT2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">BAH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116799</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RSC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFT2"/>
    <dbReference type="STRING" id="590646.G3BFT2"/>
    <dbReference type="eggNOG" id="KOG1827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007728_2_1_1"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000016">
        <property type="entry name" value="RSC complex member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="46"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="237"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="358"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="85982" checksum="45550D6BCC9AC4F0" modified="2011-11-16" version="1">MSIERERKKLGNRLNHSIDGILELQDSTGFPVFETFQRLPLRSGTDYYKYIKNPISLHSVRQKVKKFGYTSGQEFIQDLTQITWNARLYNQRQSRVYTHAVILDNYLKDRIIPRLAQDKSVIDHESLHYPDLGPLPADDEPLVPLESATPDVKDEDYGDNQGDDDDYDEYQSMTPQPRRDIYQGMRPQYSSPYAQSSKHITGLETGIRRGRPPTVDKPYETRIKLILKNLKKLKNGPEVPLNIPFFDRLPDRNSYPEYYKVVSEPVSLFEIKGKLRTRKYNNVDEFLADLNLVFYNNKLFYGTHSAQIFQDLNMLEQEATNMIAQELQRSEQELMAFAAPGGDGIVRFPLDSLEVNGYIYRVGDWVLINNPNEPDKPTVGQIFRLWSLKDGTKYFNACWYYRAEQTCHRYDRLFYSNEVCKTGQYRDHIASEIIGPCYVVFLTRYQKGDLEKGVIPEGSPWFICEFRYNESNHVFNRIRTWRACLPDEIRDHPEPPVIPLREPRKLIKYESPIRALLPSGVDTNMSIPNVTEGAHPNAPPLVGSVYLREPDRDDDLGQYYTSPNVTASPENDDVVNNRKAYLFTPISQSKSVGYPATSSNAGYGSNVPGYGSAYTPLGLAQSPPQEFYDMNRYKPTPPAPKPYIAGPQRLRFEAPTRRQTTPSGSGQANNFHASTSSHSKVLPGGTVSYLIEDTESLAAVSDGITKRRRTDGSGVTEIVWYRSPPVLLAQRLVSQDASVVGHSARYLNWKASQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFT7</accession>
    <name>G3BFT7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116801</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFT7"/>
    <dbReference type="SMR" id="G3BFT7"/>
    <dbReference type="STRING" id="590646.G3BFT7"/>
    <dbReference type="GeneID" id="18248448"/>
    <dbReference type="KEGG" id="cten:18248448"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_1"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="26"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="372"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="344"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="64"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="491" mass="52781" checksum="193A5ADD9121BD67" modified="2011-11-16" version="1">MLRSNIKSSRQFNLGQFIRFASSKSYDVVVIGGGPGGYVAAIKAAQLGFNTACIEKRGSLGGTCLNVGCIPSKALLNNSHLYHQIQHEAKSRGIDIAGDVKVNVENLQKAKQKAVTGLTSGVEMLLKKNKIDYLKGAGSFIDEHNINVKPLDGAEDYSVEAKNIIVATGSEVTPFPGIEIDEERIVSSTGILELSEVPNRLSIIGGGIIGLEMASVWSRLGAEVTIIEFQNAIGAGMDDEVAKQTQKLLAKQGLKFKLGTKVTKGVREGDVVKIEVENVKSGEKEELESDVLLVAIGRRPHTAGLNFENVGLEVDQKGRLVIDSNFRTKHEHIQVIGDVTFGPMLAHKAEEEGIAAAEIIKTGYGHVNYGNIPSVMYTHPEVAWVGANEQQLKEQGIKFKVGKFPFIANSRAKTNVDTDGFVKILADAETQRILGAHIIGPNAGEMIAEGGLALEYGASTEDVARTCHAHPTLSEAFKEAALATFDKPINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW11</accession>
    <name>G3AW11_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zf-UBP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_100543</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW11"/>
    <dbReference type="STRING" id="590646.G3AW11"/>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009969_0_1_1"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="224"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="312"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="66555" checksum="7D5E09CC44144F40" modified="2011-11-16" version="1">MIGTDSYHIVIEFPDLQDKEAILDYRYSQLEVQSINNTKKKKPFKMNSREPIKAKFLGEGIVRLYREFEDDSDSDDGPEEVKSTVVSNQGDDTMLSIISIPTYFTATDVLGFIGEKYMAYITHIRILKSEKPNRFLVLLKFNDLVKTAEFQYNFDGKPFNSMEPEACHVVYVKSVRIESPNSQDTKLVKSTNDALIPFLLNDPFTSPETKTSTDNTTLVELPTCPVCLERMDAEVTGLLTIPCQHTFHCQCLSKWKDDTCPICRYSNNVSNQKVRRSIRRLSQYSSARMQSVALPHSAAGGTSTTSESTTTGRSSLFDSVSEETETCAECSTIDNLWICLICGNIGCSRYAPEQHSLKHFVNTGHCFAMEMSTSRVWDYAGDNYVHRLITNQSDGKLVELPEKGSSSSDKPNSSIDKVDEVGFEYSQLLISQLASQQEYYEALLSEKNSGHAVGKSRRGSSITEIMNTKAITNLEIKVDELTEQLSQINLDVIPSLKDKIKLKDEKINRLSKDLNESKMFNETLSSKVEYLTSSKTELEAQNQDLNEQVKDLMFFLETQEKFKDEPQDVKDGTIVIQKDAKSKKGKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW92</accession>
    <name>G3AW92_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_128891</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW92"/>
    <dbReference type="STRING" id="590646.G3AW92"/>
    <dbReference type="GeneID" id="18249349"/>
    <dbReference type="KEGG" id="cten:18249349"/>
    <dbReference type="eggNOG" id="KOG2527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057172_2_2_1"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="158" mass="18395" checksum="90A923B8A743FB2D" modified="2011-11-16" version="1">MPKPFQPISDILNTTSPTKPQSFNEIYGEPENFLEIEVRSAQTHNTGREVFTDYEVVCRTNIPAFKKRHSKVRRRYSDFVRLKQILETETSRVVIPSLPGKILLNSNKFNDLNIEKRRQGLEKFLSIVSGHPLLQTGSKTLIDFIQDDKWDPKPLNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWC4</accession>
    <name>G3AWC4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">CANTEDRAFT_112227</name>
    </gene>
    <organism evidence="31">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">ATCC 10573</strain>
            <strain evidence="31">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28 32">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27 32">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWC4"/>
    <dbReference type="STRING" id="590646.G3AWC4"/>
    <dbReference type="GeneID" id="18246411"/>
    <dbReference type="KEGG" id="cten:18246411"/>
    <dbReference type="eggNOG" id="KOG3087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_1_1_1"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000745">
        <property type="entry name" value="Serine/threonine-protein kinase BUD32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="15"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EGV66784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="259" mass="29382" checksum="0CD44F6E5EF18735" modified="2011-11-16" version="1">MTDRVVQLVEDILPGIPLQVVSQGAEAVVFRTGVHPYTAHPSLTNPNQFIIKYRPSKKYRHPKIDASITKSRTAGEVKFMHRLAKAGINAPNVVSADFKRGLIWMEHLGEVLPSGEVSSFKNHLWSVERTRSPDECVSEDIQRICEQVGQLIGQLHHNDMIHGDLTSSNIVLQKKVPYLIDFGLSSYSGLAEDKAVDLYVLERAIQSTHSMYAYKYNQWLLKGYEAAYGTNKQNRRKYVEVMGKLEDVRQRGRKRSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWG8</accession>
    <name>G3AWG8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_91703</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWG8"/>
    <dbReference type="STRING" id="590646.G3AWG8"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040438_0_0_1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000039">
        <property type="entry name" value="Siderophore transcription factor SreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="86"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="499" mass="52855" checksum="FBCE1E5280B74FCD" modified="2011-11-16" version="1">MSFTVKTESDSSLLANLPTATVNTTSNSPAGAPNPSTISPSPTAAASTYTSTDTSTDTSTDTSTDTSADSIKVNSIKVDVVSQNEVSDGQSCSNCGTKTTPLWRRSTNGTLICNACGLYLRSNNTNRPVNLKKTPNLITVENKKHGSCAGDGQCNGTGGSAACKGCPAYNNRMFLKKIHEEEKPKAPTPQSDDLAIACFNCNTTITPLWRRDDGGNTICNACGLYYKLHGSHRPVRMKKATIKRRKRNIDKEKPSSAASEIDINEQEKLAAAAASPQSVVSTVMTVSPKLSLRSPAHMDTPIQHKHSSPRHATPPQGDSSVLSLARPASAGPTLGQAFMPISMPMSMPQLPPAPQPFYPYPMAQHHFPPYNGSGRIPNGPGPFPGPPPPNAYNLPPPRPASQPSVPIKLPSIHNFGTHPATIARPLISPNSHSQSRASSSCSSSMVGSNDVPPHNPQQSPVLKQESTPPREHKALMTDLSVPVKSNKISIGGLLNEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWQ0</accession>
    <name>G3AWQ0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock transcription factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Heat shock factor protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_132848</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWQ0"/>
    <dbReference type="STRING" id="590646.G3AWQ0"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465384_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00084017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="586" mass="63305" checksum="691694B1EA1E7949" modified="2011-11-16" version="1">MSKRSHSLPELTKSKHQTIFIHKLYDMLQDPQLHHLIWWTPANDSFLLVPSEQFSKALSQYFKHTNIASFIRQLNMYGFHKVNSGEDTPGDSQTLVWEFKHSHNQFRKGDVDSLRLIKRRSSKNNSKEVVLDQDEYYGPTASPSSWELPPSPGGGGGVGVGGPGVGVGVGGPGGVGVGLGGPGGPGGPGGPPVGTTSSAQQSYPQYHHLQHYAPHPNVSLDKYLELLNNFNHLKFDVANLLNKFDYFLNEYRFQQKNLVKLIEILQTNNLNDLNNFKHYLLSNLSNSVILNDGFNKTSSSGTVPAPGLVQNYTLNPRYNVQDVQEERPATVQSNSAPAGIPQVKREHGSTSSSGSGSGAGAGSGAGAGHGSAGGPNNANGANSSSLTPPVVTPSNISVPAFHQPFALAPNTPQPQGPYPTSEPSSNLVLPTPHIVSHKPSRSYSPLSKEERSDTKILDKIEKFEKNFQYPFPAIDPPTPRHSIDTPGANRATPQHQAERERERERDYRPAEHDRGHYSRTPSMSAGKGTVGAHNSNSATPVTGLGLGLSPSGPGSVLGPDSRKRSYQLPSISQLDESLKMRKINDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWW6</accession>
    <name>G3AWW6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112346</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWW6"/>
    <dbReference type="STRING" id="590646.G3AWW6"/>
    <dbReference type="GeneID" id="18246482"/>
    <dbReference type="KEGG" id="cten:18246482"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049046_1_0_1"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="344" mass="38187" checksum="F6484A7E6B67C914" modified="2011-11-16" version="1">MVVNNPNNWHWVDKNCLSWSSDYFKDTLVGLKAEKDSQTVKISAVSSVEGDCEVSQRKGKVISLFDMKLVLKFDGFTDTADKSSDVSGSITVPELAYDTEEHDLQFDVSIYNETNTKDAIRALIRTQLLPQLRQVLGGFGGVLIKTNSSDIQLESDKVNSVFTKSNQEAHTAVQKAPKENQSVKKNIKKETISSSAAPKATSSHIPKYNTSTLHLEPSFNTTAEQLFLTLLDPQRIAAWSRSPPLIEPTPAAVGSIMKLFGGSITSKITKLVPNEQIVQDWRLEDWKDGHFAHLNISLNQGSSETKMVVKFDGIPVGEEDRVRGNFEDYYIRSIKITFGFGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWY7</accession>
    <name>G3AWY7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_100465</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWY7"/>
    <dbReference type="STRING" id="590646.G3AWY7"/>
    <dbReference type="GeneID" id="18245382"/>
    <dbReference type="KEGG" id="cten:18245382"/>
    <dbReference type="eggNOG" id="KOG1991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004196_0_0_1"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="787"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="932"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1042" mass="120514" checksum="6AAF0FC4F792BD66" modified="2011-11-16" version="1">MNSSIDDQLILEYFKGTLVSDPHIRRESELQLAKLHRLPGFLESCVKIINSHNGPIEYPVPKETQVACAVYFKNTINRYWGSGEIALADKPFIKSNFPQIMIDSNYNIKQQLLPTLRILIQSELHDWMDLLQTVNALLGDSFNMDSINNEVELNKVYTGMLCLSEISRSFRWMKNSQRQELELIIEEFFPRLLFIGECLSSDSANLNEFKAEILKLILRCYKFVTYLDLPQSLQTPASIIQWGQFHGSLVNMKLPAYVLNARLSENEKNQFQLSKVLKWSLANINRCATRYVTGSNFKYDQFKAVYVHEFLPYLVSNLVSIVEMWCAGTRWLNLSALYYLIEILRTSISLKNLWVPIKKILPHLVQYFMYPIIVPSDDKIETFDNDPHQYISLTFNVFLDDTNAPDTAAINFIKTLLQQRKKYSFGIIMSFIHDELLALVNMEETLDSAKKREAILRLVGSISGNLINSSENKFYDHMEEFLMKLVLPNVRSNYKFLVARTFEILGSFSDLEFKSEENLNLVIYEVLKNFGFNSHPIETDLAVVLENSLCLQSYLHIPQFKETLSVMVLQVISKLLEISNEIDNDTISVVIQECVETFGQELQPFGKELVDKLVRNFMRIVSEQEGDEKSDDYEGVDSNDDKVIAGIGILNTIVTVLISFEENRYVVRELTDKLIPMIKYILVHRNENYLSETCEIIENLVYLNKDVSQDMFDVLRLINDLINDGLGVMYFEEMLPALKNYLLYFEDEQPSPLDTEFIEIFLNVFIHMNENVESLGDSVLNFELIQYFILILKVKSVGYFNVIIGQLIPLFKVFDTPNPDVNLYFRISFLNIIICMLIYDSNFVIINLNEMFIKFFLGHWIQVIPKLTRCYDIKLSILGLISLINNNNLVANPDFATNLVYLLKTLPTAIRDLRKRRKQFIADFKDEFDGSRSTNAEDGDNYGSFGDSGDETEADEDIVNDDHCDFLDFLTQENLKLLSHEENIIEDPLETTPLDHVNLPEILKNFFSLLQTKKNDRYLELFGSIPEQELQGFIKKLIIASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXH5</accession>
    <name>G3AXH5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_100908</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683639.1">
        <property type="nucleotide sequence ID" value="XM_006683576.1"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3AXH5"/>
    <dbReference type="GeneID" id="18245419"/>
    <dbReference type="KEGG" id="cten:18245419"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_1_1"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="237"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="662"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="735"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV66381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1310" mass="142828" checksum="0959AFD46AF0C844" modified="2011-11-16" version="1">MSGLQIAIDRGGTFTDFIARIPGQPDYVFKLLSVDPKNYPDAPTEGIRVILEKLHNKSIPRSQKLNLHSIESIRMGTTVATNALLERKGANVCLVTTKGFKDVLTIGNQTRPNIFDLSAKKLGHLQKMVIEVDERVTIAGFSEGGGDHLKLDDSDPMVVEGATGDKIKILKKPDYLKIEHDLKELYDEGDCKTIALCLVNSYAYPEHEAKIAQICKKIGFQVSVSHELQPMIGIVNRASSTVADAYLSPVIKDYLEGFANGFEGGLEAFGNKLLFMQSNGGLCPWYKFTGLKAILSGPAGGMVGFGETCYDHDTKRATIGFDAGGTSTDVARYSGSLEHIYETVVSEISLQTPQLDISTVAAGGGSMLFWNNGIFVVGPESAGSDPGPACYRKGGPLTVTDANLFLGRLIPEFFPHIFGPNQNEPLDYEITTKKFKELTDEINASGDVQKAFTPEEVALGFLNVAVESMARPIRTITESKGYGTAEHNLACFGGSGGQFAVSLAKNLGISDVAIHKYSSILSAYGIFLADIVIEKQSPISVAYNKDHFEFIDKKVKGLVNAAQKDYEDQGLTAFDTRVEILLNMRFVGSDTHLLISKEEAYDADKRFVARHQKEFGFILDRKVLVDDIQVLFVVESKDKKVHNPYEEFRKLTTIEVEQSSLTNPVYFEENGWNETQIIQLKSLKIGSKVRGPAVILDETQTLLIDPQSTAYVLSSHVLITVEHNNKPQISSTLIDPIQLSVFGHRFMSIAEQMGRTLQQTSISTNIKERLDFSCAVFDKDANLVANAPHVPIHLGSMSFAVKYQLNLYKKSVDGKEVFDLKPGDVLVTNHPIAGGSHLPDVTVITPVLDENNFPMFWVASRGHHADIGSISAGSMPSDSKTIYEEGAAIVSHKLCTEGKFDEAGVKRLFYDEPAKFPGGSGSRALSDNISDLKAQISANYKGITLLQNLVNEFTRPVIELYMGGIQSTADTAVRNLLKLAHKKFQGNSMKAIDYMDDGTLIALTIQIDPETGSAVFDFTESGDEMYGNMNAPKAIVYSAILYVLRSLISSDIPLNNGCLIPITLKTRKGSVVDPSYDAAVVGGNVETTQRIIDVVLKAFEAAAASQGTCNNFTFGINDQENNIKFGYYETICGGAGAIAVTDPKAERKHGQSGVQVHTTNTRITDTEVFERRYPIIVHEFSIRAGSGGDGYHRGGDGVIRDIEFTYPNLQVTCLMNRRALAPFGLKGGQDGLRGQNTWLKKTDEGYKSVSLAGRCSVTIGKGDRVVIMTPGGGGFGSLDFVADDVNYPIKPEKSIYTGSVAMRAMTQETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXY3</accession>
    <name>G3AXY3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_133133</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXY3"/>
    <dbReference type="STRING" id="590646.G3AXY3"/>
    <dbReference type="eggNOG" id="ENOG502RYK5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479935_0_0_1"/>
    <dbReference type="OrthoDB" id="5310959at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="8">
        <location>
            <begin position="2"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="562" mass="64330" checksum="C7A24C4E460E7538" modified="2011-11-16" version="1">MSIELIQKLSQQLNLDTFIDTDAYSHIIDQPYHDESGNSIKFQRLSIAGSLILIDIDFLDSVIYRVSFSSANQLYDNKLSDINSSGAESNTKSPPTVYKQDNINVIKLTFAFDSVESILDKKEYNNIEVILLKSLQAPKLMNFPRNLKYLAKLDRLSNTHIDAFTYVDNAASILKAIYSLETQASVDWLIEAGYSNSIGKPCINKPWSNDVGIFLEFWEDFRYINHEYQQEGSGLLLGQKYSLLFDLDQSTRKSPTDFIGEARDHIWEFNGEKYQLQFGDNTYLTTGRSSITASTKNDTSFTSNWAFNLVLSHPIYLPINIIEFIGIESFEESDFKDDTFFDKLNVEKDFYVHSKVNKGLKFSIKSDIHSKFVSVRSLSIKTLRDIPLFIRIFRNQIVLTNILKQLIWSNGCKIGGEVEEEDKDFEAKSKLKNSLSLANLDDQLLSLHVLNKSKFTETEETDLDEFMNEESPFESDAEEGLVVKISEMSYNTKNLDTFIEIFGKFNDLTVDIHLKISNGEIVSNHINSVMDDEAITQYNRFIKCLNITEDIVKSLNHVYPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY28</accession>
    <name>G3AY28_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_118390</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY28"/>
    <dbReference type="STRING" id="590646.G3AY28"/>
    <dbReference type="GeneID" id="18248636"/>
    <dbReference type="KEGG" id="cten:18248636"/>
    <dbReference type="eggNOG" id="KOG0303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026859_3_2_1"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="647" mass="71577" checksum="3F86C23C9C89FDCA" modified="2011-11-16" version="1">MSGRFVRASKYRHVFGQAAKKELCYENLKVTKNAWDSDIIKSNGKYISLNWDSSGGGAFAVIPVEEVGKAPDTVSLFRGHKGPVLDTAFNPFNDQQIISCSDDAKILVWEIPQDYSFHKYVDANDKIKDITEPKKVLSGHTRKVGKVQFHPCAENVVASSSLDYSVKIWNLETGKDEITLQHKDLVTSFAFNYNGTLLATSSRDKKLRIWDIRAGKIISEGPGHNGAKPSRIAWLGNTDRIVTTGFSRLSDRQVGVWDVNAIDKGPIDGFLVIDQSSGVLIPVFDESTSILYVAGKGDGNIRYYEYENDYLHDLSQFASTDPQRGFSAAPKKSVNVKENEILRAFKTVNDHSIEPLSFTVPRKSELFQTDIYPDCPSGKPSLSAEEFFSGKEFNGPVLMSMEALYEGTEPSFHESKPSVNVSVAKEKAKEVEAEEKAKAKAESEAIPKKTTLDKFEETELSTPGSKSIDDTLKSSSEVNSLLHRVNDSSDIDEEVESGVKDEEWEEVKKPDELPDSVKLVGDDKSEPSSTVTPTPSLKTVVESEPVSKIATTTSEPSVEKPIEKPAEKPFEKPVEKPVDVKSPVPEPEPKEPTKTESKAPTLKATIERFASIVENLEQQVSKLTAAGLEKDERLLGLEKKIEELLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY62</accession>
    <name>G3AY62_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_118447</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY62"/>
    <dbReference type="STRING" id="590646.G3AY62"/>
    <dbReference type="GeneID" id="18248643"/>
    <dbReference type="KEGG" id="cten:18248643"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011302_1_0_1"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV65776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="65580" checksum="6AE5FB1B60C16FC9" modified="2011-11-16" version="1">MIRESPSQVVGEAVPNIDHAVSVSLPTWEATVGYEEGEDWVVSKMSSGYPRFFFHPIIQTLSQRVEEKFGRSKEKCMIYPSYDIAKRCRAFIQEKAPQKTPVRLLQLSTPEPKSEAEKSSVIATTIGVVFFPTSVASLAKNYWQHAGEGISSRLAEYLLKTLFDESSSGQHSIKFNPVDLGASKSELQAKKIQALSPSLSVRKPRKDENMQESDIHIEQKYGRVLDLKFGDAAKTALRKRITGGLAEHVQQSTDTPLNYEDVYLFSTGMAAIFNAHRALLNSQEPRMSVCFGFPYVDTLNILKKFGPGVHFLGMGDDKALEELEENLENGSYNIMGLFCECPSNPLLKTPNLKKIRQLADKFKFAIVVDDTVANIINVNVMPFADIVVTSLTKIFSGDSNVMGGSLFLNPNSPMYSSLKQFFDKDYEDTFWVQDALVMERNSRDYAVRSKKVNETSLAIVDFLQKSPLISKVYHPSVSESKKYYDEIKTPNGGYGGLISFLFHDANDAVSFFNSMDFHKGPSLGTNFTLACPYTILAHYQELDEVEKWDVDRNLIRISVGIEDKDDIVEVIKFSLDETTKTHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYB8</accession>
    <name>G3AYB8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_133235</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYB8"/>
    <dbReference type="STRING" id="590646.G3AYB8"/>
    <dbReference type="eggNOG" id="KOG0959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008088_0_0_1"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="62"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="437"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="804"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1079" mass="124774" checksum="0FD3F47A17E9F1C1" modified="2011-11-16" version="1">MPIEIARSGNFWGHLFVPGFLFQVRLVHKDTNETKSKSSEVPNSKSDDQLRAVTLDNGLTALLISNPNMETTAISISVNSGSNNDGDIKGLAHLVEHMLFSGTKEFRQPYFLIDNISKAGGTINAFTSYNQTNYHLEASNTSKSIRNINPQVKSDDGVVGYLIHMFSRFFKNPVFNNQCIKNEIKDINEEHLANLNSESKRFYHCLKLLVSETHSFHSFATGNTNTLSSIPKLRKHLVNYFERYYYASNIKIVIKSSLSLNQLQKLAVMNFNDIPDKPISPQLALPFFQTYEKGNLLQVETTKQPKMRVVFPINQLNDSLIQISKVWIELLGQEEPGSLCFHLLKQNFATEVNVFDQLVDFNNLMIFIEIHLTTNGYNNIKTIMRSPVKRIGKVIDQCLRLEKFEFIYQDNDDSSMDELQSNLPTSLFLIETKRWLNIRSSNLIVFGPSTIDSRPMKCQLSDEYYTLNYCVCRLDSKSVDYDSVPEFKLPERNKFLIWSHEELDSMLHQFHEFQGNMNMNVKFKIDQPPFLAEHSQNLELWFKKEFTFNSKCFVSFQLCSKSLEHNCRHLVAVDLLCEALGVALASSLYHSEKLGFSWSIYPSLNGTNSITITLIGINMLFKEILQELIGIVVDELRNLQSLPYSLFMRYRVGLRKRYKKLYEEEYLVQSMAAGMFVMETNVFSIEEKCETLEEIVLEEVVAISLSLINDSYTSIFLNGDGTVDDCYDISHIINRLSNHLSLDTTRKVNDPSSFQPIIGKFRFEIPAATANDFCYFYIHLGERNNSYIRTISKLLEYVTGRNIHKLKSERNLGYRIVSGLKIFRKTMGLFLYVESNEYSYKMLSRNIEDYLHVIESEIESLNNEQFREQMLNPCLNSLEFHNETQFSPDTVFDLLPCKASTNFENDSKSYFIHKSTWVQILNRNYRFNAKNGNEEVDVDLLRRVTRVELLKMFTLLVSPDSESRSIITITNDENSQRLSQKINDYIDSRSLSITSEAKSNLLKINEFDIIKEVLEKRFTQKNGMNIKGFLKPIGNDSQYLYPSKQKERTMGVSRYHHTTDIIKDQQDHLERLEVYISGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYH8</accession>
    <name>G3AYH8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_92191</name>
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        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
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        <name type="synonym">Yamadazyma tenuis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
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        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </comment>
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        <property type="project" value="InterPro"/>
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        <source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="365" mass="39665" checksum="E855C5BEEBA93E0F" modified="2011-11-16" version="1">MSRRNNQSSTANSTILYIGGVPFDWDENNLRSVVCGSGGVVDVRLGFDYSGKNKGFCFIEYITPEEARQGLRLLGQVLIHQGGNKSKKLRVELSKEGLRANNQTSKRLLQLDRNYLPSNVELPQEMLGNGPTPSYYNPQQQMGGGGSPVNQINQVNQMNQRGQQNIQNDQQQNSGLSSRNLPQPPTLPFKAPDKISENLSNIPPAQLIELIANLKGVLSGPNANRAPDVFQLSPYLASSAAQALLLMGFIDTNVINDAINAPQFDSTPQMQNPQPVHNNPQQPYGVSPQIPNATGGIGSNGMNPGVPMPSKWPFLPPSTQVKLGAMPPEQADLIAQVLTIPSEQIPALEPEKRAMVTTLRAQYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYK6</accession>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
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    </protein>
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        <name evidence="10" type="ORF">CANTEDRAFT_92216</name>
    </gene>
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        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cten:18250171"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
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    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="Ovo-like"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="RH12261P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
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            <end position="376"/>
        </location>
    </feature>
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        <location>
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            <end position="445"/>
        </location>
    </feature>
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        <location>
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            <end position="568"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <end position="329"/>
        </location>
    </feature>
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        <location>
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            <end position="344"/>
        </location>
    </feature>
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            <end position="363"/>
        </location>
    </feature>
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        <location>
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            <end position="421"/>
        </location>
    </feature>
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            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="568" mass="63754" checksum="281343D697AB5AF6" modified="2011-11-16" version="1">MSSHNPDRSINPNGSETNEGTTVVATSTLGSLNSSRSTSKEKELGASTSVTADLSVNNSKTTLSSRSQDSSNGISVNADMTTPNSSISANLRPSATKEHPTDNLETKDNYDSPGEGENDQKRYYCSTCNKGFTRKHNMVSHELIHSQVKPHICSVCSLTFRRIHDLKRHEKLHTGTKPFKCQYCPRSFARPDSLVRHQNSPSACPKAKPSPVGISVPNTELGRNSVVAQSFGNPHRPRPELPSLRSLSSQYPYKLRRPQPQMTYSRPDVFRNSLSYQRVPEQHTETVTREDGFGGFTTTTITTTRHRENNALTESMPSSESERLPRQTDDSQLGNQALNQSNIGNIPLYSSEKDQDQDHDQKKVKSQKGVNKNESSQILHGALLNSQDKANIDHAMSFSRANPDLPQINDQLSAGSSNSDDPNPYPRPRQEEEQSFGPKADQDQAKKLTPANLNIASQYPGRPEDTEQAYQGNRRLYYNQSRDPSVYQYPNEEYISLSRYQDLVAYTQSLEENMNKINSRIQILEDENADSKIERERAKHAHDSTSRHRKRHKKDMSANIGAQQERPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYM4</accession>
    <name>G3AYM4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_133313</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYM4"/>
    <dbReference type="GeneID" id="18249693"/>
    <dbReference type="KEGG" id="cten:18249693"/>
    <dbReference type="eggNOG" id="ENOG502S3IE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043057_0_0_1"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="538" mass="60668" checksum="D533078985D31484" modified="2011-11-16" version="1">MKTKGFKGKRFQESLVKSEASHPMPETSDDYLDLGATEEESGDRWISSDFSKALRFYQRAYDAYMSALSKSANSSASISDLDIHYNISRLLLHVYNQYFQTDGVHINELINVDDVLLSAQSVVQKLPTVVESHERALQLSKDLRTQPSMDLLYNTGVAYTQVLEDIKNHGDIQLIEVMELGTKAKGLFQNLLDRQVTQLQSFVEELDSMGQTSNLQDPSEFSHDSTIDSQNAVGEDTLQPPHVFETITLCYKLSHAILENTENPTQDIPIFRELVEPFLSTCDHIADNLIGSFSGTKNLQSEFLSSISDQQINEYKISKAYNHSLILNDLSEIISWWESSLSTIADIPEKYLAVSDSLQGFLDRNDISLKTCNESNHQEMIKTFWQALTIMTNNLKKAQELMNGQKQALQKSGGDNLGTLVSQLSNVLIARSDIDIQRCQLNDEQAIKNQSILLQNSKVFLKNASTLAGTSGGLRERAVEKLSRKQRQVESVTRLCLLENKTTVEELDVIIGRSRWVREVASLKKLEYFDSFGVQQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYT1</accession>
    <name>G3AYT1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_102071</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of the 850 kDa m-AAA protease complex, a heterohexamer composed of YTA12/RCA1 and YTA10/AFG3. Associates with the prohibitin complex, composed of PHB1 and PHB2, inhibiting the activity of the m-AAA protease complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYT1"/>
    <dbReference type="STRING" id="590646.G3AYT1"/>
    <dbReference type="MEROPS" id="M41.002"/>
    <dbReference type="GeneID" id="18245528"/>
    <dbReference type="KEGG" id="cten:18245528"/>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_23_2_1"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097002">
        <property type="term" value="C:mitochondrial inner boundary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="277"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="7"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV65921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="741" mass="83402" checksum="E6171F08F3D73306" modified="2011-11-16" version="1">MLNQQNRDNKDHKEDNQKDHDKQDHEKQKEKTKEEEEKEFREELKKRLKEKNPNLDLNNLNFYNIDRGTINKVLGGLLLGGILIAMLASNSSPDHENELSFQDFKTKYFMKGLVTKITVVNRYLVKADLIQGAVSDQTYQAYNGKPAIYFAIGSVDFFEKEINEIQNNLGIPINERIPISFSEKDDWMNYVLPILPTLLLIGGIYYLTSRRPNSPGGGGPNNIFKIGKSKAKLFNQENDVKIRFKDVAGCEESKEEIMEFVKFLQNPTKYEKLGAKIPRGAILSGPPGTGKTLLAKATAGEANVPFLSVSGSEFVEMFVGIGASRVRDLFKTAREMAPSIIFVDEIDAIGRERGNGRMGNDEKENTLNQLLVEMDGFESSDHVVVLAGTNRVDILDKALLRPGRFDRHISIDIPDIEGRKEIFKVHLSKLTLKCDEDIKATKQDVDFNKYQQLKSEAIENLAGRLGALTPGFSGADIANCCNEGALIAAREDATSVDVPHFEQAIERVIAGLEKKSRVLSLDEKKTVAYHEAGHAICGWFLEFADPLVKVSIIPRGQGALGYAQYLPKDQYLLSKEQYYHRMIMTLGGRVSEELHFDTVTTGASDDFKKVTQMAQSMILKLGMSDKIGSIYYDNGEDAEGYRVHNNYSEKTARLIDTEVKRFIDEAYIACKKLLTEKIELVDSVAEELYKKEVLTREDMIRLVGPRPFRERNDAFDKYIKGTDAFKPRKKIEDQGSAAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYX7</accession>
    <name>G3AYX7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heme oxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_101828</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_006684467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYX7"/>
    <dbReference type="STRING" id="590646.G3AYX7"/>
    <dbReference type="GeneID" id="18245503"/>
    <dbReference type="KEGG" id="cten:18245503"/>
    <dbReference type="eggNOG" id="ENOG502QT8P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077537_0_0_1"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19358">
        <property type="entry name" value="TenA_E_Spr0628-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026285">
        <property type="entry name" value="TenA_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050967">
        <property type="entry name" value="Thiamine_Salvage_TenA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198">
        <property type="entry name" value="BIFUNCTIONAL TH2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198:SF2">
        <property type="entry name" value="SI:CH1073-67J19.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003170">
        <property type="entry name" value="Pet18p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="3">
        <location>
            <begin position="13"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="225" mass="26453" checksum="3AA96DA26D73ECDD" modified="2011-11-16" version="1">MSPSDELLENYFHWYQQSISHPLTNELCAGTLPDFKLFTYLVQDLKYFETGADLISKTMRLSDSKEASSTIYEYIGGLSTENKYFHVCIHELKQSEEVQKRVPHMLGENSETLPAVKKYIDYLDYLLNESNSYVELITVVYIMEKVYLGWVEFNLQQGSISKSLEYKHQEWIDLHSGEDFEKWVKFLAQEVDRVAPSDMETFEQTAKKTLELEVEFFEDCYNYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYX9</accession>
    <name>G3AYX9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_92304</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYX9"/>
    <dbReference type="STRING" id="590646.G3AYX9"/>
    <dbReference type="GeneID" id="18250184"/>
    <dbReference type="KEGG" id="cten:18250184"/>
    <dbReference type="eggNOG" id="KOG2238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012852_0_0_1"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="290"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="606"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="801" mass="91233" checksum="4EDCBBD931247C46" modified="2011-11-16" version="1">MPFLSFLYTYLLGGVTFLPLLVIVFIYLHPKDKTFSQPDKQDDDDESPPKLLSAGEIEEDSSSGILAYKSGWLIVTQEYLESPDEISSQTQSINESSSAYSTLYKLVKNNNPNGDQNEVAEPISPRPANDKTKSLNKKHRYYALLKHGNLFLYKSQDLKDVKHVIVLSNQFVTLWPRDLPDGQLFTKRASICLIKKDWTRRRRLSENFENDKLTVQDILQSENNLTPPQGSFFIYCDTNIEKEDWYFTLIKASKSESDLGPWSSQLHAKTLHFQTDEMMDLIQTLYSSEGQLQTKWFNGLLGRLFLSLKRTDMLRNFLETRITKKLNKIKTPGFLDKFKLGNLDPGDSIPFFTYPNLKEINPNGTLLISSYVHYHGNLSCNISTKVNLNFGGRFTQSQVDVVLKVTVQKIEGPVIFKIKPPPSDRIWYSFEIEPLINLKIEPIISSRPITYSIITSTIEKRFKDAIKESLVVPNYDDVVFFDTEGDVYRAGVWDKTQSSDSSETALDDEMIKKSELNTDDAYRNDQSIRSVRSVDSDTSSIDKLKLTATLSDLSQKIKKSKSTHTVGVTGSNFLSDGSIMEPRQRTLNKNLNKTFKKIGDWYNSKDETKDKKEQDKVEMYSNRRRPRQASNERIPEQNLSSPVDMFAKNKSAHSRSSSKFSVSSDYSQQSESSPRGDFSPQARSLRAENLPDDNYSTSSLGPPTFGKFASDIIEEESSIFPQRIEMSEEKPSTQLPVAALLKTSSGNSDFSVEQMPELNEKIPNPFDEELNELIQLDHQVSNENEPHRTASKLHRRSPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYY2</accession>
    <name>G3AYY2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRMT5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112835</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYY2"/>
    <dbReference type="STRING" id="590646.G3AYY2"/>
    <dbReference type="eggNOG" id="KOG0822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616761_0_0_1"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="2">
        <location>
            <begin position="154"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="3">
        <location>
            <begin position="317"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="444" mass="51452" checksum="C28ACABCECBBBD15" modified="2011-11-16" version="1">MDVAGNKVFYSSNEFSQLDEARKLCCYCLVECDTWDVCEVLDSSYNYVLLIDLPLLQQIRKLPSHISVIVPLMSIPEEFYGSDVTIWIQVTRGSALSGLELQKLSTYPNLKLYVTEISDALRCLLLNCKEVVVQDTQLVPQISTIERNLSKLYQNSQFIITPLNPLADNLSVQVYEQFQKDKIKYQQYEDAIELAIQDLKTQYTDLRVLVIGAGMGNLVDSVFKFCSHITVIEKNPQTIDILRRRNHNDWNSEIDLIFDDVRNVDVGDKYHLVVSEMLGSFGCNELFPEILQRIKPQIMIPEYITSIVAPIYSTIVNHTVFLNNLRNYYRVADYQRVWEYNYPGQNDNEHQSEFQFPVQIDGKVNAFEGLFRADLYGNIGITNMKGPNYCNSWFSMVFPIDEIIVKKGDLLKVRFSRISRNRVWYEWQVNDINYNQSGAFSMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYY9</accession>
    <name>G3AYY9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_118948</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYY9"/>
    <dbReference type="STRING" id="590646.G3AYY9"/>
    <dbReference type="eggNOG" id="ENOG502S4MN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114639_0_0_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="148" mass="17332" checksum="887C9D6B62AE3194" modified="2011-11-16" version="1">MSKEEQELEQLWSYFKDSPDDIKEKRQKLTASLSRTDLGAYPSTMSISTAFDELFQCFSIGGQIKNYYRYGELSYCGKQREKLWFALRHGSFVSETQVNEQSSMKDIETAQKIQQFHKQRLLNEKAHGSSEDVWDIRETPLVNPFKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ81</accession>
    <name>G3AZ81_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_112894</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573</strain>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ81"/>
    <dbReference type="STRING" id="590646.G3AZ81"/>
    <dbReference type="GeneID" id="18246725"/>
    <dbReference type="KEGG" id="cten:18246725"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="35"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV66288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="365" mass="39320" checksum="7B9961D319FEBD02" modified="2011-11-16" version="1">MFRQLTRRSAVIPQFTRSYIPGQFTGAKKANGKYTVTLIEGDGIGPEISEAVKEIYAAADVPIEWEPVDVTPLLIDGKTTLPQPAVDSVNKNLVALKGPLATPVGKGHSSMNLTLRRTFNLFANVRPCQSVQGFETPYKNVDTVLIRENTEGEYSGIEHTIVPGVVQSIKLITKPASEKVIRYAFEYAKSVNKPHVLVVHKASIMKLSDGLFVETAKEVGKEYPDVSLDYELLDNTSLKLASDPSDYKNIVMVMPNLYGDIMSDLSSGLIGGLGLTPSANMGNTVSIFEAVHGSAPDIAGKGLANPTALLLSSVMMLRHMSLNDYADKIDAAVKKTIASGPANRTGDLRGTASTQHFTAQVISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZQ7</accession>
    <name>G3AZQ7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_103164</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZQ7"/>
    <dbReference type="STRING" id="590646.G3AZQ7"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31229" checksum="C7EC32622C3C30C3" modified="2011-11-16" version="1">MTKRSFESFIRYPSDPKEVPSKPEKLSHNIMERFFLTGKVSVITGGSGSIGAAIVEGYAQAGSNIAIMDIRENLELCVRLSTTYNIKAKFYRVNLSDPQEVKKVIQTIEIDFGTIDIFVANAGIAWNFGSILNEDSTPEAWKRVFDVDVNSIFYCCKYVGEIFKKKGKGSIIMTASMSAHIVNVPNYQTCYNAAKAAVLHMGRSLAIEFVDFARVNTVSPGYTNTPLSDPVSVEERSKWWALTPKGRECEPDELVGAFIYLASDASSFTTGSDIRVDGGYCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZR2</accession>
    <name>G3AZR2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="3">4.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ureidoglycolatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_102946</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; (S)-allantoin degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ureidoglycolate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="3"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684905.1">
        <property type="nucleotide sequence ID" value="XM_006684842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZR2"/>
    <dbReference type="STRING" id="590646.G3AZR2"/>
    <dbReference type="GeneID" id="18245595"/>
    <dbReference type="KEGG" id="cten:18245595"/>
    <dbReference type="eggNOG" id="ENOG502S1JQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070848_0_1_1"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.480:FF:000003">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="214" mass="23540" checksum="DF666E19CC1F381B" modified="2011-11-16" version="1">MVIKTFDVSNTKTIEAVPLTPEGFSPYGGVISADHQILNVESSAANYGTAQKIHKVAPVVNNYEKCSSGKPATANWNIFRCKAPKHLISSSGIGKTYLSKVLERHPFTTQTFIPMGQDLHKKSFLVIVAKTDETSPDMLPDPSQLRAFVCKGNQSITYGAGTWHAPMVVIDEEVAHIDFAVFIHENGVADEDTQECYFEPGYSVNYSVARDKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZR4</accession>
    <name>G3AZR4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_133532</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZR4"/>
    <dbReference type="STRING" id="590646.G3AZR4"/>
    <dbReference type="GeneID" id="18249718"/>
    <dbReference type="KEGG" id="cten:18249718"/>
    <dbReference type="eggNOG" id="KOG2176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009437_1_0_1"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="77"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="448"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="873" mass="101191" checksum="580794C1EE984335" modified="2011-11-16" version="1">MAPSIANGNGVITSSNGDRYSNVNGRLGTEKSPLENLLIRDEDIFQTSLNSDDYLESIAPIVKDALKSNGLSDLIVKLNDIVKSKDEALAELSLSSAQDMNSCIDSIDRIHDDSTELNRSLQQVSSFLNKSVYELVSRKKSLLKSKELTSKINETTVVLNLCVQVLEITNRIHELIKQNKYFSALKLLDELANIHLPKVENFSFAKKIYDSLPLMRRTIKDESFDNLCKWLTVNVEKKLYDIGLGLFVNMADIHERWQQIVKKNGSTFFSHRVNSPVEISMRDPSLNYNILSDPELKINLSTVYYAILAFQTLNEDDTLSKLYNREWLKKYNRVIYPITSSVRTSMVASAKFNDQVAEFQDLASLDEYLKKISGFFVIDKQINLSTKFEIRTSKQSDDLWESYVTKLKPVLLHFLKTHPFNIDELEQFKDLIGNFMQIMENSEYKIIELYDVLIILVKDYLADELIQQFRYDFLTSIQSDHYMPLVVQEKKDYESVTQICWYKEDAPFAPRHVKKLPISFPFSEDYVHFCLGIRSLMEDIIQFVKDFYGYELNELNNIIVEQIFERVLGDEKGVGIVYDLRDFITKNSSNKEILSQSYTNFEYYLFSLYELGKLINRRLKLYNGIGLNNVDINGTLSLRSKDLFTQLRKYAEESIFKMVDDKVNELLDMVEYDDWYPRIANREPHFSIKDFALFLENLFTSIFTNLPSTFRTLGLFRSYDFIAQHFLNILKEAEGYNHIAIDNFDLDVRHLESSIQALSQHDDSDPNEGEGLVSLQSTFTELRQSIDLLKLDNYEDFKKNPSFRTRKFDRVKYEDGVKLINKMLVTEEDNISTLSANEESFNSSAQSLDQQSTLSNSTTAKFAKFSNRFRNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZW7</accession>
    <name>G3AZW7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_112996</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZW7"/>
    <dbReference type="STRING" id="590646.G3AZW7"/>
    <dbReference type="GeneID" id="18246772"/>
    <dbReference type="KEGG" id="cten:18246772"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="275" mass="31459" checksum="271E4582A86C7F46" modified="2011-11-16" version="1">MSGAGNRESVFPTRMTLGMMKIKLKGAQQGHSLLKRKSEALTKRFREITQRIDESKRKMGRVMQTAAFSLAEVQYAVGGNISYQIQESVKNARFKIKAKQENVSGVLLPAFDSEIDEEINDFKLTGLGRGGQQVQKAKMVYTRAVETLVELASLQTAFIILDEVIKVTNRRVNAIEHVIIPRTENTISYINSELDELDREEFYRLKKVQEKKQIAAEADELEEQQKIAKQAQDQLDEKKLEEEVEKLDIKHEHQDEGEDESKDLLNDKDDDVIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZX7</accession>
    <name>G3AZX7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 21">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="6 21">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 21">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 21">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTEDRAFT_97198</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="21">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="6 21"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZX7"/>
    <dbReference type="STRING" id="590646.G3AZX7"/>
    <dbReference type="GeneID" id="18250666"/>
    <dbReference type="KEGG" id="cten:18250666"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_0_1_1"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="15 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 21" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="23">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGV65267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="505" mass="55325" checksum="18C5BE98D52DDE61" modified="2011-11-16" version="1">MDMRGGRTYKDAIAALNTLQSNFASLEAKRQIGPSVNKNEYSIKVVYEYIRRLGYSPKDFNRLNVIHVTGTKGKGSTCAFTESILLQYVANGGGPGGIKKVGLFTSPHLKSVRERIRIDGKPINESLFTRYFFEVWDKLSNTTSDADEFPDLEPYDVVKPMYFKYLTILSFHIFMSEGVNTAIYEVGVGGKYDSTNIVEAPTATGVSALGVDHVAMLGSTIDSITWNKTGIFKRGSPAFSSVQHEYPQTHQQITERAEELGASSIEFVDGVSVAGVRLGLQGEFQRDNAALAVKLAAAHLAHLGVTDLPSSDLSYLPAPFKEGLARAQWDGRCQVIDHKPGFEGLSFYIDGAHTLESINVCTSWLATRSEFGGAGSRRKVLLFNQQGRDNANQLLTQLYDNLHGRVSFDTVVFTTNITWASGYNAELVSMNNSQAAIDTLSVQKGFAEVWEQRDAKYGKKTEIKVFKEIEAGLNSLKSLAPADVFVVGSLHLVGGVLSVLDGDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B057</accession>
    <name>G3B057_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_103032</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B057"/>
    <dbReference type="STRING" id="590646.G3B057"/>
    <dbReference type="GeneID" id="18245600"/>
    <dbReference type="KEGG" id="cten:18245600"/>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013424_1_1_1"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442711" description="Endopolyphosphatase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="14">
        <location>
            <begin position="59"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV65324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="597" mass="67495" checksum="B0F2741B0528EA40" modified="2011-11-16" version="1">MLKLIAPVLALYLWACSVTAPGLTASEVRLEAAAASDLQALNLTVRNPIAVNNQVIHGRFLHITDIHPDEFYRPGSSPDKMCHGGHGDAGRYGDAILGCDSPLELMNQTFEWINTHLKDKIDFIVWTGDNIRHDNDRNFPRTEMNIFDMNEHVSGSLYELFKNPDTSNPRNLVVDLIPSLGNNDVYPHNLFAPGPTLQTREMYKIWSHFIPQNQLHIFNRGAYFFREVVPGQLAVVSINTLYLFRSNPLVDNCDRRKDPGYKLFEWLGVVLKEMRARGMKVWLTGHVPPNEKNYDISCLRKYIIWSYEYRDVIIGGLYGHMNIDHFIPLDSRAAYRSLAGSGKVSVADWDGDESDDDDDDVDLVQQPPMRIAGGTPLNKVRYMDSVRSDVYGKIAKRRKSGPHGDRYTVAHVTASVIPTFNPGLRVWEYNTTGLASMLNNQPASANWDQFFAGVDRHMAYLDTVDDVDHTRGVSMFDYFSSRKDNTLPPKKPADIPVGPAYTPQTFTPLRYTQYYVDLASVNAGKKPFGYEHEYSTDDRTYHMESLLVENWLSLGRSLAAPVKNPVKAGDDPALAQLWDTFLAHSFVDSDYENLGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0B3</accession>
    <name>G3B0B3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_133661</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0B3"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:iron ion transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
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    </dbReference>
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        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
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        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442779" description="FAD-binding FR-type domain-containing protein" evidence="11">
        <location>
            <begin position="23"/>
            <end position="613"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="12">
        <location>
            <begin position="275"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="13">
        <location>
            <begin position="454"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV65359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="69879" checksum="E803628EEA3C5620" modified="2011-11-16" version="1">MKFAFKMRLSLLFLGLFSVCHAHTPSQYRYTSEADIESQSCGDYLSKLATFCDDPQMEDCYCVNNNSMASYMGCLSVEGKLKPTILESIVQSCAQYNVTVEQLEDAYEYYQTSAVSADDIPDFNVSVPVDVPILVDEEIVMQYKLSYVYVYGTYNNSLYYGFGPLGYWVLALLIASIAHWTKFLAPGFVKKRYGRYTNWFRKNFTMSAVCKNRTEPMKIRGIPIALIPTRVETAVSVGYLVVVIVCSGSQIKYYADDKYYSDGTKSLAKYVAVRTGILASYSSPLLILFAGRNNFLQWATGWNFATFMGYHRWVGRVVFILVLVHTVGYTISFADQYAEYMADNYMIWGTIATIASGLILGQGLLVLRRMSYEIFLFWHIVLAVLFVAGSWLHVDTLGYVNWYYATTAIWCIDRVVRVIRGWGYSQASQPGQTVKMRVGIEGPYGESTPARYCDTAVFVAGGNGIPGIYSEAYDLARRDSKQKVKLVWIVRDYKSLDWFYEELQFLKGKNIETIVYLTRPTNQTAESDKEKKKTDDSDGSSFKVAEDLCHVEFRHGRPDVEDFVKHEIEESNGSIAFVTCGHPEMVDHLRYVVSHNLSEEKRIEFYEQLQVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0U0</accession>
    <name>G3B0U0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_104467</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="cten:18245718"/>
    <dbReference type="eggNOG" id="ENOG502S0DZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020178_0_2_1"/>
    <dbReference type="OrthoDB" id="4074002at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="12"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="421" mass="47873" checksum="3E987A54E837B2EE" modified="2011-11-16" version="1">MWGILRTALTVYVSLFLILITVLSIYWGSFYHRESRLSNQKTLLVDLDSPIRVNGTEIPGIGRDFVDFVTTDSWAQARCGFTIVNSSYFNAGENITARVAQMVRHQKYWGAVVIGPNVTAGLYEAIQSQNASAATLIPYFINWYYLKSRHLSTFSTTYRYSLEVLETLWVNNGSFNTQSTILQSLSASEQVSLLRNNETVPLMTLKPTINEVDLGASSDISVLGPSQLGLVYAQLFTVYQFMFFQTIYKVVREKISTRSYLFFRWAASNFNALFLSLVYCLATLAFQISVTDTFGHSGFLVLWMILYMFILTNGFISDTVISLVMAYEKPYLVAPCTILNVVVNLATTFSPFELMPRSYRIGYALPMYNTYQLMRVVFFDSWKGTMGVNIGVMWIWIVVGTIVSSWVFVIVKRLDESKRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B144</accession>
    <name>G3B144_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1682-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113637</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685969.1">
        <property type="nucleotide sequence ID" value="XM_006685906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B144"/>
    <dbReference type="STRING" id="590646.G3B144"/>
    <dbReference type="GeneID" id="18247057"/>
    <dbReference type="KEGG" id="cten:18247057"/>
    <dbReference type="eggNOG" id="KOG2357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042570_0_0_1"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833527" evidence="6">
        <location>
            <begin position="17"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="365" mass="41772" checksum="4CFEA25AE5A69833" modified="2011-11-16" version="1">MLQIITSIALMAAVAAASTTVEDVASSTVWDRIKNNDWRLELITISFTLGFVVLFKIGDLYNKSLVTKFLEGTKETLEANFFQVGVSKEDLYIKDSPENYSSYATGRENIAKVNFDFKLRPRNNIFVWILEGIMSYFTEYVQKPIDKVDIVIQPSIPYDNFISAIVSKLGMNDFRKFNYFLSLTRTVDSTKIPESFVFMSEGSEFHDKLLTPALADALTIEAASYIRYIAFTDQATEKPDSPEGYAPYRRIVISMSLPSKKAQIAQISKTLDAIFSIIDGIAEKSITFKSESLKKVAKTRETELNKILKALEQERLEIEAEEKAKLKREEREKIRNLSPEEQAKLEKKESEKKQKKLQKKQRVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1F1</accession>
    <name>G3B1F1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_113703</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1F1"/>
    <dbReference type="STRING" id="590646.G3B1F1"/>
    <dbReference type="eggNOG" id="ENOG502SGCY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062235" evidence="3">
        <location>
            <begin position="16"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="228" mass="25039" checksum="C3F404A44F1DE37C" modified="2011-11-16" version="1">MWSLWMLISLCTASALPTLVARDDSSTALPTLTYTSSAESSYTFTPVVDSADDNPYVLQETMPNGSVFIIFGSILLLLVVSAFLYFTITWAISVYKAKHQSEKYFYNAPLQYPDDGFNSSGSSVFERKSSFSNMSQLTLNQPLGRPYRNAKLENNRGSMFFSPTSDFILSSDTDSPTNFAGDSSSSFINLNSSALSLLEIGSGTVETPPNESKPKRPPSQYLEDLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2E3</accession>
    <name>G3B2E3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_120455</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2E3"/>
    <dbReference type="STRING" id="590646.G3B2E3"/>
    <dbReference type="GeneID" id="18248779"/>
    <dbReference type="KEGG" id="cten:18248779"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005476_0_0_1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="110"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="587"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="587"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="782"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="940"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="683"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="838"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="941"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="982"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1025"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1098" mass="119988" checksum="739E0095D0CB37C3" modified="2011-11-16" version="1">MSASVGDEMIDKDLSNPNVPLAGNLQTSNGSEHIKTHITSEINPKISFDLGSNKVIAIKKEPSHMSTASITSEAALGHNSSAEDKDLSKISAYARLDFDNYTFFVQTLQVILGRKSNDELLNGSQHSVDVHLSSKKAVSRRHAKIFYNFGTQRFELSILGRNGAFVDDLFIEKGMTIPLVDGTKIQIGDITFSFVLPSVEASHSKDASLSAKPFDPSDAISLRTSLYSNSNSNSPVRTNKNTNNEEQKKVTSKKSRSIPRRLSEARRKSLASATDDELNAILSELGVKTLDDIDDLDEQDPGLVDAQIRTILGTGPDNESAIIDDDDEDAQIDSGVLSSFQEGEEDELDQLVKQHNMDQGVNLDEAELSREDMSLSVIDEEIVNLAPLINAHHQENALKERSSSPNSGQYSNLQRNSPLMGRLATPRMGKPASIQPPASRVYGRTAPLNKNQAIDMRLANMNMGSQMPGFPTHLVAQGPGDYSLKLAQGNLMNQSFNKVYMPPRPPVPELLVPIHTIPKQPAASPEIIIDKITVGTNYPYPPVHIPKIIGKVGMVPTVPKKRKELAPKKPTKNIYTMNEIPEHYRTKPTLAFPVMIINVLKFKNDERGLTLNDIYEGVKEIYPYYKYCPDGWQSVVLHNVRLNKLFKSSQSIDNHLQSSPGQADANQDELEEEEERWNIDESFVQEKEKVRKKQQEIAAQRAKEAAIRAEELKQKQRLEMQQSISQNIVGRDFNSPYGLPLNSHAHLLSQSQLIAQLHHKNNQSGQKPKTIAEIASEIRRDGASSKTPMYFKPQAGESKSPDLGGSPTIKAQLAANRSQYSQSPPAVGASSPTSPELAANATAAKTSTSTSMNQDTKKSLTYLQKELFTLYKARKLSYNTATTTEIITKALATTIAQVNVIGSKAGVGNNALSFLVERAPQQVSKILDIALTKSIKEKQGLLSSRSNSRGATPGPSQLSSPKPAAAELAVASTSEIYKEADRLANKETSVEADDDKDKPVVAASLGKPPVFSLNGKSPEPLTRPLSGTSPVLSRPQTYTKPGGLSKPPQFMSNKPTRPGYGAKPGEKDDKSPEKATRPKRGLEDEAGANGSPSKSPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2K8</accession>
    <name>G3B2K8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nucleoporin2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_103810</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685508.1">
        <property type="nucleotide sequence ID" value="XM_006685445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2K8"/>
    <dbReference type="STRING" id="590646.G3B2K8"/>
    <dbReference type="GeneID" id="18245656"/>
    <dbReference type="KEGG" id="cten:18245656"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005908_0_0_1"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="320"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1208" mass="134947" checksum="1B6DADD2E6EE4E5C" modified="2011-11-16" version="1">MFSNNNNTNGWNQAKGFSSTPPATAANQNSNSLFGSSSSAPKPSLSSGLFGNSTNTSKPSVGGVPTNTSTFNPTATSSNTLFSTNTPAQTSTMPTSNGSTQPYSTSTIFQGIPTNYEIPASITGDLFSDDNDSSKNTGRSFFNLASERTATDSKKDSSSLFSKIAGRFNIFKSTRVYDEALDNSKGIFAASDFPSSKTLTLGGGRGGKNRITKPVKFSSIEARSTNETKKLIIKSKPLKFHLINADKVLDSKRKRVITSLVPSDRLLNDEPEVQDDDSDFEFSSTSFEKSKLSNHSKIIRGIPEHSTSTESYGARTQTSEDGYWCSPSIHELASWSLKDLSSIDNFIIGRKGYGQIAFNYAVDLSDIKRKCSEESKSFDSELFFNIVEIGSKYVKVYKDSKTKPPRGFGMNVPATITLENINPTSGKDLNSFITVLKQKEGMEFVTYDPIVFTWTFRVQHFSIWGLEDENGREITRQSNNDDDYIKELKRQKISRDTQGLPGNWSNDADESVLNLKRNLLNNEIDSQINIFNGSPTSRLSASTKRGDSKDFLEDALINDDIVPAPANDNYEYLRKLVSVLPANIDFSEIVQEKAYEPIVEESAFNAIQPRPNIAVSDDWLVQLHLTNDLNSALAQYLSNPSVNIQEDGKHKMDSIDALLFGALNESAESSKDVSTPSVKTDDVKMADEVPEIENRAELIQNTVKFLSQLLSRSKFEKRPNGFSKVTSNKSKFSDFISFGFTKEFLVLIELCSALFDDVEIETNENGMVDDSELSTYLKGIKQREVFINWLKKYNESVMKELITNAQDNFEKVFIHICAGNVKDAILCAIEAKNHHLSAILTFIDSNFDGIKKMAKFQLEDWAGNDLIPANLLKIYKFISGDYDEVLVDLPWSIRLACKVYYQDASVKLYESIEEVAEAKESRSSSIIEVLKFYCRFHLKGEASGLEYFRESPLDISIKWPILKILGEGLDDNITLKFGKLVEQLGLWKESLFVYAHLLNDAHVETCTKQVVHENIKEIKNDKTHIDEEPYLVNTLGVPYKLIYESVATTEMNSSKDYWKACDAFITASSWDKAHECIVENLGPSTVISQDILDIRRLQRVLSSFPDNGNIIATWSQGAGIFQHYFNLFPYIKQGKSPHDKNDIIESLLDNIPVLKVDSRITSRAAACIISRDIGILAMGSKIGNLKQRVFNLPLGEDETTFFESRLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2M0</accession>
    <name>G3B2M0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_113495</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2M0"/>
    <dbReference type="STRING" id="590646.G3B2M0"/>
    <dbReference type="eggNOG" id="KOG2145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032621_0_1_1"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV64711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV64712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="420" mass="47678" checksum="5D87E18CBC97FD87" modified="2011-11-16" version="1">MTDKVTEAVKKIDLKSSEQIITPWEVEGAVVDGENQGIDYKKLTEQFGTKLITSDTLNRFKEVTGHDPHPFLKRGVFFSERDLGRILNLYEQGKPFFLYTGRGPSSDSLHLGHLVPFMFTKWLQEVFDVPLVIELTDDEKFLFKPKLTIQDVKKYCQVNAKDIIACGFDLEKTFIFSDLDYMGGAFYENVVRTSRQITFSTARSVFGFQESDSIGRIHFASIQIATSFPSSFPDVLGLPPKTPCLIPCAIDQDPYFRVCRDVADKLKYSKPALIHAKFFPALQGASTKMSASDTTTSIFVDDTPAQIKNKIKKYAFSGGQASKEDHIKYGGNPEIDVSYQYMSFFSDDDEKLESLAEAYRKGELLSSEMKEECIKVVTKVVQEYQERRAKTTDEVCKAFMTPHKLSIYTKERLVPVKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B395</accession>
    <name>G3B395_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_104661</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686428.1">
        <property type="nucleotide sequence ID" value="XM_006686365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B395"/>
    <dbReference type="STRING" id="590646.G3B395"/>
    <dbReference type="GeneID" id="18245744"/>
    <dbReference type="KEGG" id="cten:18245744"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_0_1"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30239" checksum="03DFCA356601E71E" modified="2011-11-16" version="1">MNLHQDNFGTLNQEYDICLLGTESSGKTSLVLYYIHNRYIEEENAPEDLYTKVVRTGHSYNEVTILDLNPRQDNYSSSRKRQLMNNSGMVFAYSITDHHSFHDMEQLYEQVVELRGGDQMPPVVVVGLKSDLEDERNVSYEEGKQFSDQIGALKFLEANSRWGTNVDKVFEPLAEIIRQKKSFGRRLSQVAISPRKSPLASTPEGSPRKAKNHIGRIEEEVVKSEDFHSAEVVPVKHESPSKKDESVMEQVHEDTKNSSRCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3A3</accession>
    <name>G3B3A3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_98101</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3A3"/>
    <dbReference type="STRING" id="590646.G3B3A3"/>
    <dbReference type="GeneID" id="18250745"/>
    <dbReference type="KEGG" id="cten:18250745"/>
    <dbReference type="eggNOG" id="KOG1696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083919_0_1_1"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="188" mass="21702" checksum="70EC530964942236" modified="2011-11-16" version="1">MANLRTQKRLAASVVGVGKRKIWLDPNETSELASANSRQAIRKLYRNGTIVKKPAVVHSRSRARALKESKSLGRHMGYGKRKGTADARMPAQVLWMRRLRVLRRLLAKYRDAKKIDKHLYHSLYKSAKGNTFKHKRSLVEHIIQAKAEALRENSLKVEAEARRSKNKAARERRQQRVAEKREAFLNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3B7</accession>
    <name>G3B3B7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114153</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3B7"/>
    <dbReference type="GeneID" id="18247291"/>
    <dbReference type="KEGG" id="cten:18247291"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_0_2_1"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="312" mass="35889" checksum="128CC759328C5268" modified="2011-11-16" version="1">MSIPDEFDAVACSLEADTKQKYTALLTDFEKSLESYWKFETVDGMFKQSDDSTDEYKFDYLKEDFGRLLSWEETFAKLDELNSNAPANECYKVFFLARHGQGYHNLANSTYGNKEWYRKWSELNGDGKIVWGPDPELTELGVSQARDNAHVWAEQVKKGVKLPTVWFSSPFRRSADTLINTWESFVDISTIKPLIMEDFRETIGVHTCDKRSPRSVIAAKYEHLGFVIEDGFEEEDVYWKPDYRETIEEHGIRTNRAFQHIFNNCEDEVVSITSHSGAIRAQLLVLNHRPFSIGTGGMIPVVVKGTKYEKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3B8</accession>
    <name>G3B3B8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_104690</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686445.1">
        <property type="nucleotide sequence ID" value="XM_006686382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3B8"/>
    <dbReference type="STRING" id="590646.G3B3B8"/>
    <dbReference type="GeneID" id="18245746"/>
    <dbReference type="KEGG" id="cten:18245746"/>
    <dbReference type="eggNOG" id="ENOG502SB0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333441_0_0_1"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="698"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="736"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV64131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="795" mass="92225" checksum="83D919DDC3C67663" modified="2011-11-16" version="1">MKFGKSLIELTIPEWKSYNLDYNDLKSQIRLVSESQVSLASLNRKFLSNFEVINMFVKTKHADISRKLEHYDNSFDALLENDDGANVKLIKMDMLVSSLIDLSITLKKLSKFILIQKIAVKKIFKKLSKKHPDPYVSSKIIFNLKLVLNRDRQSFVNISLVDLTLRLTNMINLIKFEMNKLRHKDQELEQDPMFSEGDGKLTNLKFDFNVLLKKNFSLTFILPDDSSNFNEVLLNMNIYLSFQRLSEKESTNSIIFLQNDENLSSQPSYVLSELGETYSLIISHIGGLRKFSYCYLPNNIIDSMFKYLHNSNNEECEEELKEYFRTHTVNSLTKLTIDSLLNKNLKPKVKVYTKTLRYYIDKYSSVQPDNSGLLSEPLQDDYLLNLRYDICTTNAVGQINTTDFNVDDPDLDKFPFNLLELNSNDSNLLRFEKTLLTEIKDDNQLVNKFSIGHLGKLPDPIQKLIKNNNSINLFRNFNLYQYTLSSYYNVVPQDINNHFSKLLNMNLFKSFENIENFNNDLSFDSYILKDNTDKMLKNQLSLNDLEHQAKLSKQKQSKASKASSQYSSRPNLKKNSSLQSMSSSFNLSVFTNDKSRPNEFDDLIEDEDNDSLRIFWNEEPEARFKRSNSNSNLSNFVLNLIHLKSRMNRVGETTSLRGSNDYINDYQSVSVNSNSNQSVDYYTTLNHYYYEHDKILSFFYLTLSFSSIFIASVEFGLTFSILKLQQTNQFQVNDNMWFFGILSIGIIISFICSMLAFNLIFKRFSAPSCLHYGVIVISFALILLCIILCALLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Q9</accession>
    <name>G3B3Q9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavo protein WrbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114281</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flavodoxin-like protein (FLP) that plays a role in cell wall integrity, oxidative stress protection and virulence. FLPs act as NAD(P)H quinone oxidoreductases. Reduces ubiquinone (coenzyme Q), enabling it to serve as an antioxidant in the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Q9"/>
    <dbReference type="GeneID" id="18247353"/>
    <dbReference type="KEGG" id="cten:18247353"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="5">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="200" mass="21421" checksum="334D75089F3DBD54" modified="2011-11-16" version="1">MAPKIAIIYYSTYGHLYAAAQEVQKGVQSAGGSADLYQIKETLPEEVLKAMHAPPKSDVPLASVDTLKEYDAFLFGIPTRYGNVPAQWKAFWDQTGGLWAAGALYGKPFGVFVSTGGLGGGQEATIINSLSSFIHHGMVYVPLGYGEAFPLLTNLTEVHGGSPWGSGLLAGGDGSRKASELENKVFNIHGKTFYKTVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Y8</accession>
    <name>G3B3Y8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113924</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pichiomycetes</taxon>
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        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
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            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
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    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
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        </location>
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        </location>
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        </source>
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    <sequence length="459" mass="49940" checksum="F6E08BF1739E41ED" modified="2011-11-16" version="1">MFKNLVRLNIRLKVPSYKHSHIFGAHGFHTSAKLFINFDPYKTLGVQKDADQKAIKKAYYDLVKKHHPDVNKETDAEEKFHKIQESYELLSDKDKRAQYDTYGQNFDNPYGSGGQGGYSTGNPYGGSGGGNPFGGMGFDFEDLFKQAFNGGRGGSGGGGRAFVTEHVGDDVEILKSIPFKDSVFGTKIKVNYKAVDSCNSCKGSGLKTGKAKSTCPTCHGSGHATHIIGGFQMSSTCGTCGGAGVTINKGDQCTSCKGHGVEEVPKSTEIDLPPGIKDGSRLRIPNMGDSPIVAKDAFTATKNGDLIIRINVQDDKLFKRVGNKIVTEQDILMTTASLGGEIVVPTIDGENVKIKVRSGTQNGVKLSIPDKGFPINRNVKNRDDMEVLLNVKSIVPQTPVQRALLEALADTINDNNAKRSQQHEHFNDDSKGEQHDNEHDSKLHKIGKMLSKFFNLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>G3B402</accession>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="OrthoDB" id="5600212at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV63903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="696" mass="78286" checksum="FDABA4BFCF7FBD9B" modified="2011-11-16" version="1">MENSTSDSDSGRGDISTTYNTGRVTKPPPSTSGKISKSCDHCKLKKIKCDQKKPTCVNCVKYGETCIYSVMKKPGLRSGYGQQVFERIEELDNFLEEKFDTLEKRYTGPSVATSSTIRPIPLNFQSTGTDPMNLSTTNPTITPNSALISAGPGPMFTRNNSSNNYTPNTNSAISPPEDIDSLPPLDKIEVLVELYFELVNPVFPILHPTLDRPRILKTIDTSNFLLLGVLVSTVKLQINLFSPQEAERYFAFIKSKIVSSCFAVRTIQELRAVALLAFTLYGESNNHEAWSMISLAVGGCLHLGIIKDFPLNNDLLGIPQNELVSLNRTEGAEWEVWAEKESIRYLMWEVYKLDKLSSMGSHFVSKLPQEEVSSLLPLKADFWEFKSLYNKALIEKEQTHTLNDFNFKPGNRDIYGSNCYLIQVLNLMGRGSKFRGSPMDIKDMGSILAWQLGCYEFEKEIQAWKSSLPDNVSQFLDSEILMSSQITVKDVILHSLYHTMIIRLHSPTAFSDSQDKYLISAQTSKAKCLKSAHLILKISKSLPSLFQIDEESVFPIFGPYYAFSIWVSGRVILVDAIHSQGQLEGEFDYAISLLRRIGQKWECAAKYANILEFFKDDTMTVDTSSHDGTGEFYSSNSYSEDARLIADIKLNASSLDSLLSKKVARYKNAKGNIDDLSIFDWFKLPLNNVFMPSQMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B406</accession>
    <name>G3B406_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantolactone reductase</fullName>
            <ecNumber evidence="4">1.1.1.358</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-dehydropantolactone reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ketopantoyl-lactone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113936</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16719"/>
            <dbReference type="ChEBI" id="CHEBI:18395"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.358"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>isatin + NADPH + H(+) = 3-hydroxyindolin-2-one + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27539"/>
            <dbReference type="ChEBI" id="CHEBI:28536"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.1.1.358" evidence="4"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686219.1">
        <property type="nucleotide sequence ID" value="XM_006686156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B406"/>
    <dbReference type="STRING" id="590646.G3B406"/>
    <dbReference type="GeneID" id="18247189"/>
    <dbReference type="KEGG" id="cten:18247189"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047011">
        <property type="term" value="F:2-dehydropantolactone reductase (A-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00051098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="309" mass="34383" checksum="CE790FDB0EFA3253" modified="2011-11-16" version="1">MVKAFKSTKVYKLSTGSSIPALGLGTWRATDEEVYNSVLTALKAGYRHIDTAAGYGNEEPIGKAIKDSGISRDQIFVTTKLWSTKHYDPESALKESLSKLGLEYVDLYLMHWPLAMNPNGNHPAIPTRPDGLRDIVYDWSFTKTWKLMEPLVEQGLTKSLGISNCTVSKMKELFDSGLKVKPVCNQVELHPYLPQHKLLEFAKEHDVVLEAYSPLGSADAPLLKDESIKAIAEKYGVSSATVIISWAIWRGTVVLPKSVKPERIESNLEIIELEDKDGEALNRIAENRGGPQRFVSPPWDPVVIFDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B464</accession>
    <name>G3B464_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">CANTEDRAFT_113828</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686099.1">
        <property type="nucleotide sequence ID" value="XM_006686036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B464"/>
    <dbReference type="STRING" id="590646.G3B464"/>
    <dbReference type="GeneID" id="18247136"/>
    <dbReference type="KEGG" id="cten:18247136"/>
    <dbReference type="eggNOG" id="KOG3185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_0_0_1"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="245" mass="26337" checksum="A105F398E435BAF8" modified="2011-11-16" version="1">MASRTQFENSNEVGVFSKLTNSYSLVAVGGSENFYSAFEAELGDVVPIVHTTIAGTRIVGRMTAGNRRGLLVPTQTTDQELMHLRNSLPDSVKIQRVEERLSALGNVICCNDYVALVHPDVERETEELIADVLGVEVFRQTIAGNVLVGSYCSLSNQGGLVHPQTSIQDLEELSSLLQVPLVAGTINRGSAVVGAGMVVNDWLAVSGLDTTAPELSVVESIFKLQDAQQDAITGDLRDTLIETYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4B9</accession>
    <name>G3B4B9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">CANTEDRAFT_97958</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686259.1">
        <property type="nucleotide sequence ID" value="XM_006686196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4B9"/>
    <dbReference type="STRING" id="590646.G3B4B9"/>
    <dbReference type="GeneID" id="18250731"/>
    <dbReference type="KEGG" id="cten:18250731"/>
    <dbReference type="eggNOG" id="KOG2420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029061_1_0_1"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023474589" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023474590" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="167"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="592"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="625" mass="71079" checksum="BE36DC21EAB28A33" modified="2011-11-16" version="1">MAFRPPSFNPSPTMKQRLRYTPAPFMLGPQRMNIAQPLSRASTIAELASNNSLPKNNRKNKFKKKVASYYDQFPRIPRPKRNNVLFYSSWSNSENNKSHRFPNIRLSKRSFSTANQKLRNKTFNLHKRLFSAEARKQRQQRRRFIRWWTLTSLAVLLTGVAGKIKYERGQYDDDDEHIPHNEYAIKPESWQLYIYSTLPLKAISRLWGQVNSINLPVWLRSPSYRLYSTLFGVNLDEMENPDLTSYSNLSDFFYRTLKPGARPIDDFDLVSPSDGKVLKFGVIEDGEIEQVKGMTYSVDALLGLKTEKLAAPSHSLDFEHLDDDATVLERDQEFAKINGITYTVDDILGGESDRTTHKNDLQYKDAGDRADADSKATLKKELLVARDLTPTPLERLGLSGSKQLYFTVIYLAPGDYHRYHSPTNWVATLRRHFIGELFSVAPFFQKTLQGLFVLNERVALLGYWKYGFFSMIPVGATNVGSIVVDFDKDLKTNDIYEHAVYSKSRQSSVDSISSADENTPLIPEKEPELDVQESTSDLTLVSESSQASTPKAEKPKRLKKNTVYEATYTKASRLLGGYPMNKGSQIGGFKLGSTVVLVFEAPDNFKFDLQIGQKVKVGQSLGRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4C0</accession>
    <name>G3B4C0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_113971</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4C0"/>
    <dbReference type="STRING" id="590646.G3B4C0"/>
    <dbReference type="GeneID" id="18247199"/>
    <dbReference type="KEGG" id="cten:18247199"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_2_1_1"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33971" checksum="244C420873915375" modified="2011-11-16" version="1">MSFLNTIRGLGRGPKKNKKDLDSTNVFYQHPNGSGSPVRRSQSPTKLSPNKQQRINQVYNKQASPTRRGRSHANGDGSTRLSPRKEAARLVAPVTTINAPQDLPLFLQEPFVKTSLVKGSFKTIVQLPKYVDYGEWIALNIFEMFNNLNQFYEVFAEYMTPEAYPSMNAGPTTNYLWVDSSGQSINLPAVQYINYVLTWISNKLNDQSVFPTKSGGAFPQNFMKDCKNITRQMFRIFAHIYYNHFEKIVHLSLEAHWNSFFSHFISFVKEFKLIDKNELEPLLPLIESFEEQGKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B590</accession>
    <name>G3B590_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114484</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573</strain>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687358.1">
        <property type="nucleotide sequence ID" value="XM_006687295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B590"/>
    <dbReference type="STRING" id="590646.G3B590"/>
    <dbReference type="GeneID" id="18247441"/>
    <dbReference type="KEGG" id="cten:18247441"/>
    <dbReference type="eggNOG" id="KOG4163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_1_1"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="207"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="679" mass="76078" checksum="37ADA248725D3771" modified="2011-11-16" version="1">MALEQSLAALSLATVSSESATPTKTLVFKPKTAKTATPVPVIVFALQSTQTPSNVIAKAAGVKEPRLAKEDLIQEFFATSPKEFSIANLNKDSAAKVKFVIDESIVKAPEDTVLELSTESSKASLPAKIVVSFLESIGVDLIAVDFSADELTEVAPKKEVKKKDKDAAKIEDAKLIGINVDKAKDFSTWYSQVVTKGEMLDYYDVSGCYILRPNSYFVWETIQDWFNIRIKKMGVKNSYFPMFVSSRVLEKEKDHIEGFAPEVAWVTRAGSSELEEHIAIRPTSETVMYPYYSKWVRSHRDLPLKLNQWNSVVRWEFKHPQPFLRTREFLWQEGHTAHLTRAEATEEVDQILDLYAGIYEELLAVPVIKGKKTENEKFAGGDYTTTVEGYIAATGRGIQGATSHHLGTNFSKMFDISVENPEGADKPKVFAFQNSWGLSTRVIGVMVMTHSDNKGLVLPPRVAQNQVVVIPVGITSKTTDEERKAINDGAAIIEKRLKYADIRALGDYRDIYSPGWKFSDWELKGVPLRVEFGPKDMKQEQVTVVRRDNGEKSVVKLADLEKRIPEVLDQIQYSLLANARKEFDEHRVIVNEWKDFVPTLNAKNVILSPWCGDADCEDDIKDSSAKKDDGEDEEVDEKAPSMGAKSLCIPKEQPTLKEGQKCVKCDRAAVNYCMFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5D1</accession>
    <name>G3B5D1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_93961</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5D1"/>
    <dbReference type="STRING" id="590646.G3B5D1"/>
    <dbReference type="eggNOG" id="KOG2451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="472" mass="52417" checksum="419B3550E61ED403" modified="2011-11-16" version="1">MKIPLLVNGQEIHTDSHYSVRSHTEDEKCLHITSCLSVDDIDAVCDSSQEGFEQWHLMKVSERIQILRRAVEILRQKKDELMESMSELGIPPWFCHFNTDQLVHQLEEYVNQMNGTYGEVVRSEMSDLAITVNEPVGPVLAIAPWNAPGVLTGRTVCAPLAAGCSVILKTSELSPKIGYILVKALHEAGVPPKSVQLVHFQPENNPEFVTKIIEHRSIKKVSFTGSTSTGRQIAAVAAMNLKPCILELGGKNYAIIESDANLEKAVGAVLWGSFAHKGQICMTTDKVYVHEDVYEDFLGSLQQIAPKLLEDPDYHIPQRNRQFTVRIQNLIDDALQNGAKLIFGNRSEIDPFKNTAISPVVLGDVTSSMRLDTAESFGPLVTVYKYNDAAQLVRKLNKEPYGLKTSIWSQNILRAQKLAHTIESGGVNINGPTVYDEPTVPHGGVKESGYGRFNSKWGLQEFSYIKTITMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5J0</accession>
    <name>G3B5J0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_114542</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5J0"/>
    <dbReference type="STRING" id="590646.G3B5J0"/>
    <dbReference type="GeneID" id="18247469"/>
    <dbReference type="KEGG" id="cten:18247469"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_1_2_1"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000051">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="18">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV63589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="412" mass="45366" checksum="0F90F229852CD5EC" modified="2011-11-16" version="1">MRKCKVFVGSSHPELGRLVCERLGVEPAPCSLKKFSNGETSVQIGVSVRDEDVYIIQSGSPEINDHIMELLILISACRGGSANKITAVIPQFPYSKQSKMKKHRGAITARMLANLLIMAGADHVVSMDLHASQMQGFFTKPVDNLFGAPTLARWIRHNVPEWEKAVVVSKNPGGTKRVTTLADALKINFAMIHTDRRRTHDGYSSKNKKKNLKTSRASKTADEEEDNIVSEMQTARIVQGHVVDDDYQAGGNPDPQSHPEKTPILDSDALGGSYDADNSDDEDELTLTSQEKLITLVGDVNDKPAIILDDMIDKPGSFIAAAEHLRMNCGAKSVYILGTHGLFQDKCLETLNESSCIDKIVVTNTYPISKERIEQNKKLSVIDVSPIFAECIRRDHFGESISVLFDSLAAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5V3</accession>
    <name>G3B5V3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_123411</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5V3"/>
    <dbReference type="STRING" id="590646.G3B5V3"/>
    <dbReference type="eggNOG" id="ENOG502QZJZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013659_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="801"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="921" mass="104784" checksum="AF5FC57AC4C22F50" modified="2011-11-16" version="1">MSDNSPEYSSMKRTRVACETCRRKKIKCSGSNPCSNCQQSKETECVYIEKLRKKSHHDKSISKRSSTFKAVKTLEHKLSRLEGFMMDMSEKLDYMAGLGSGSKSNTLKGGLKDNDNSTDSSESGSSDYEEDEYTDEADLNDQEEDDQKRPDFADTEYGKNGHHQIKTVHETTDKYGIISKLSELSRKGKRNSNRKSYTIYNMRQTFFETHSFFSVCSPRSLQWISRSLAPSKKKVLDQFNKFPYFLYTRSNKFLAKWTDPVLITPENKTRLLERPLPEDRALAFSLLEHCKPQMVFEEYLISPESTRVLFDRYYKKEKMLASELLILCSLMYIFIGASLDEREGNIESDNRQISLCNTPTLDAYGEDDLIKLQSQFLVSSIHYYQKVSVMSEGVSTVQAILLFIIYLELTLVKSTANYILAAVAVRFAQEIGLHRCESFEGLPIEEVAFRRKLWWFCEYLDIEICYRHGKPPLINPADVSTLTRKDFISGSTVKNLPFNINTDNHLDPKLLKFLLEEKGLDVYFGHFMSLLNRLRFEAYSKLFSASSCDHSFTDIIYILTSMNKKMWELGSSMSPELRPRFYNDSEFGNSALFQNKTIEDGQLVMLLSFHLAFFTQLMTMNRLITRLKCDPHEIEIKNSEAIYLRDLASDSARTIVHITLRTVRNTISASNLSWLIFYSSAAVLDILQSCLNKPKSEDTVSDMELLIDGMINCSVKQLFRNPPKNGEMFNQIDSVMCLVTFIMLQMGIRIVESQSKRVFFDNNPYLIQISNHFMALFPELYQKKRADPILRAEIVNPATQSDRSSTASDLIGDSKSNFTATTAPSTDSTGNSMNSFGEVSPMGCPGLIPGPTGYLSVHDPKNPLINSVWDSKVSPNYGNSPSPSTYFSGKIPLGDPEFNEALDRVFGGGTPNFFYDNSIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5V7</accession>
    <name>G3B5V7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114610</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5V7"/>
    <dbReference type="STRING" id="590646.G3B5V7"/>
    <dbReference type="GeneID" id="18247503"/>
    <dbReference type="KEGG" id="cten:18247503"/>
    <dbReference type="eggNOG" id="KOG1258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590499_0_0_1"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF23">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT PRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="50724" checksum="F1ACAF0F1564BC4B" modified="2011-11-16" version="1">MEQISIDLLKDPYSVAKWDRLLQQSVQKLSKASTDQYLPTVRAVFDALLTIYPLLENYWLKYAHLEYELANFVESKAIYNRALRYVSYSPRVWLAYLEFCLVADPVCVSNCLQYLKLFESARSYVGFHYFSADFYKLYLEFLSTYKNIDPTLNFQLKYERLLRYVLEVPMYNYSPFFTSMFDLIDSGELTHTSDKGLRKNITDIYVITQYKAFKLYDFEKKLHPYFDLKPIAINELKTWEKYMAYLELNYPHEYVIQAYERSVLATCNYNDLWLKYMNYLTNLNKLDSLNEVLKRAISLRKFNKKELIDRLIDLNLFNSNFLVSKNLLSTQVSINKLTSLEWLFGNTAVITRLFESSQPWELLVYHQLDNDTKLKLFKSCKNETKEYRQVLRFWLKYNPQYRNQFKTITDTTANDFDEELTAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Z0</accession>
    <name>G3B5Z0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_135164</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687129.1">
        <property type="nucleotide sequence ID" value="XM_006687066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Z0"/>
    <dbReference type="STRING" id="590646.G3B5Z0"/>
    <dbReference type="GeneID" id="18249850"/>
    <dbReference type="KEGG" id="cten:18249850"/>
    <dbReference type="eggNOG" id="ENOG502QVWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013298_1_0_1"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="84882" checksum="09FD4241B7CDA61B" modified="2011-11-16" version="1">MGVLKVLQDLNGSRYQVFLVVATLIILLNVSYLYVIEAQPDKSFPSISSNLRPQTDMTSEKYINVLDNPEVKASKTDVIKKAIAQIKAENEDRIIKVLEKEVRSKNEASILTKVKLTLKRQMIRKMFRQDVMSGRLMDDMKQKYLSDNEHLMKSFITKDLIQGLKQKEEFKKFDDPALKQLAKLLEEQLADRAKNTVFFQYILEELIGAHDPKVKIELHQISENIIPTYINNPDAKNSITLKDLSRLKLKDQQIESLQQSHDRLVRLLTTLEVPKESVFSGDGIVINTGDIGIGSVLVLVSQLRNTGSVLPIEVVMNTWKSADKKICDEILPQFNAKCIFIDRAIPKMSKSLPQKLEKFQYKVIGLFISSFERAIVLDSDNLPIDNVDTLLYCQEFLKTGFLLWPDIWFKSTSPEYYNIARFEVGEPVRRDGLSNNKGFAQYVSSGKKHSNVAFHDLDGLPSAGTAETGQLVVNKRKHIRSLILTLYYNIYGPNCYYTLFYQGGAGIGDKDTFVPALHVFNEPYSMVDKSTDLLGFKSGVNMDGEFVDTTLIQYAPTSAKYHLIEWKKWLKTKDLDTRLSPFQDNDYTRNLYKQFMTHCKKLIEVEEELDDSSIKLKPLFLHIHRPKINPLENYNSLGIRDKRILGKKEEYVPKLGEDSDWELHFHSLSKWIACDLLKDSQIFATFELDQAAVCDGISKHVDYLKATSWFHPSEFVGDVVTLNSPQDDQTLPAKVETEDEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3B610</accession>
    <name>G3B610_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_114651</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B610"/>
    <dbReference type="STRING" id="590646.G3B610"/>
    <dbReference type="GeneID" id="18247524"/>
    <dbReference type="KEGG" id="cten:18247524"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_0_1"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="103"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="195"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="283" mass="29727" checksum="877325DBC19BF606" modified="2011-11-16" version="1">MEEVDSVLVDNVKSFASGGFGGICAVLTGHPFDLVKVRLQTGVYDSTLKGIKSTLVKEGLPGFYRGVVPPLIGVTPMFAVSFWGYDVGKRLISSATGLSPAQFQISHISAAGFLSAIPTTLVAAPFERVKVMMQISKEKSSMGSVIAEMYRTGGIRSIFKGSAATLARDGPGSALYFATYEYLKQALTKPGEEGLSLLNISIAGGCAGVSMWLGVFPIDTIKSTQQSSNTNTSIVQTTKNIYAKGGIKAFFPGVGPALARSFPANAATFVGVELATNFLNSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6D8</accession>
    <name>G3B6D8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114748</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6D8"/>
    <dbReference type="STRING" id="590646.G3B6D8"/>
    <dbReference type="GeneID" id="18247563"/>
    <dbReference type="KEGG" id="cten:18247563"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019916_1_0_1"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="93"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="429" mass="48013" checksum="1DABAF0120D3DCC6" modified="2011-11-16" version="1">MSIVLPSLPTGAEGPVVKAKVTTPVRRPIEPVGRYFLSHATRTLRGHTWSEYEKLEAENNVTAVEENVDDDIGDEDQDEELLEHDPRDWKTADLYAVLGLSKLRWRATEDQIRRAHRKSVLKHHPDKKSASGGLDQDGFFKIIQKAFEVMLDPVKRRQFDSVDENADVKPPSPKSQYDFIDAWAPVFEAEGRFSKTQPVPSLGTMDSTKEEVEGFYGFWGKFDSWKTFEFKDDDVPDDTANRDHKRYIERKNVSNRKKLKQEDNKRVIALIERAYSEDPRIKMFKDEAKKEKERKKWEKEAGSRKAAEEAAAKKAAEEEAAKKAAEEAASAKLTGKKAKEAAKNAKKKQKRSIRGCGKDADYFGDAGKASDVDADLDLIVDKLDDVQLADVAAKVTGVDAAGVKSAISAAADELAGAGKLDKSFLKYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6F0</accession>
    <name>G3B6F0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HRQ family protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_106598</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687244.1">
        <property type="nucleotide sequence ID" value="XM_006687181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6F0"/>
    <dbReference type="GeneID" id="18245901"/>
    <dbReference type="KEGG" id="cten:18245901"/>
    <dbReference type="eggNOG" id="ENOG502RZ1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_2_0_1"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41573" checksum="107F553DCA3B6E21" modified="2011-11-16" version="1">MLAAIFVLTVLVATYSLFHLYQRHTAKPKGPVSVISNIKPIDKSFRWDTTEPEKIRPFVNKKDFRPNMGIKNLAAQPEQWLLIEDTYREVTTKKRDITSSNVDKTIQINDSPRSQLAAREYYDSCINFFLMRYPQYFVKKGNQVYNKINDDYVPASSAGEDPMALYLALARTMEEDVVVFLKDDPNDHEMEYTLRSGITGFPSGFDPSDNHDKVISEIHDVVPQYKERLKLSMGRFFNRLQPSDLWVRFNWTIQTHNQHYNLRLNHGHEGESIEEIKFEDIDFENGCFLRCERQVLTRLPKSGANIMTVRTYLTPISKIKQEGLADELCRAIDALPTDLGFYKRRPAWGTAVKQYLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6G4</accession>
    <name>G3B6G4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_123771</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6G4"/>
    <dbReference type="GeneID" id="18248978"/>
    <dbReference type="KEGG" id="cten:18248978"/>
    <dbReference type="eggNOG" id="ENOG502S235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4036575at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="327" mass="35042" checksum="2F6C8C39DCA229FD" modified="2011-11-16" version="1">MSSNDLLSYSIMQGGNKVGPISPVRLPVPSALPSSTKIVLPPIDSLKRLTEHNLNTLNTSYGGYTYSKGEVSPRSTRDSLSPPNSVKLQSPAAETRNVAGAADVSAGAAAIAALVAAAANASATVMPSPTTTVKVTTPTLSKSSVTSIPITPAASPIPIEESHKRRQRLGPSCDSCRTRKVKCNAEISILAPHYAAYDLTEFNLSPAQIESLHSDHSVVLPASDPSDAPWMLTVSHTKLIKFRACKSCACKDLECKFSKGFTKEDILVNKKSLKTRSDKQKVGKPVIDSSRKSSCFNCRKRKIKCSMNDHSEKCESCSKRNSSCSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6P1</accession>
    <name>G3B6P1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_93757</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6P1"/>
    <dbReference type="eggNOG" id="ENOG502T27P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_947017_0_0_1"/>
    <dbReference type="OrthoDB" id="4013248at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442747" description="GOLD domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="289" mass="33375" checksum="A06F1619513DF13B" modified="2011-11-16" version="1">MTPSFLLLILLALFHYVHSIGMVIEPCLEGDPAQQSSLINLRNCLAYHTNNNDLIMVKIVSGPQIQSQTLNLKIFDSENNLLRVSNNLVGEITIIMKNLNNDPIYDEGNSKRSRANIIDRLAFLKSDEHKAQQLLNNNKGKNLIYVCFDNLYSDKSWSFHPENREIELTVDLRDVSKMQGTDYNLYSKYFHKFQSTENSDHRMKDMSQVEFDDEIAVIENELNDVVENLKNSAIILKNIQLQESRLRDINEQIFAGYTFMTVLVLVAIVGFGIFQTVYVHRYLTKKVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Q3</accession>
    <name>G3B6Q3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear rim protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_93767</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Q3"/>
    <dbReference type="eggNOG" id="ENOG502S7S0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529951_0_0_1"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="514" mass="58987" checksum="A40F643D18299446" modified="2011-11-16" version="1">MGDKRRVRRTPVLEKIRNYPYDVYLFVNEAFASIDWDDYNRAAVVLCNIVSLVFVVLNSINYTPTATTSTLFHVDSRRLDKSSQALLSHSREVYAFVGPSGASGSLWISLTQSVLVVIYVASVAICYHLMFNSTRMYSVINSNTKPKTPSAREALLSDEPTNRLVQILASVLRFFNKDVDDDSYYNDSETTTNISEDLKLNGNKLVYEIDVWQPSQFCLILFSFVNPIGLLVAKIMVEMSVWKVGLTVLLFNFQMYYLINKFLVLINDKQILYQEMFQEYNDKFVKPKTNVLKQDVGIDATGKYGGLGQVVDHSNPYYQNTKSKVFIVHDINGKPFNTISKEDIDEERKLFESEKIRFELERDKFNHEQKVLNSSMDSDWLRNTIHSTPFKTPGNRDNYYNRSSLRSTERGINRSSVLNRSFNTSPVRDRDRSYMSSDASRMRSPGQPLDRSPTRPRSPVRSVGVGIGSPIRTGMTSPTRNGRLSPERPHITTPTYDTKTTRFNDRTPTINRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6R3</accession>
    <name>G3B6R3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oleate delta-12 desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114308</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686787.1">
        <property type="nucleotide sequence ID" value="XM_006686724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6R3"/>
    <dbReference type="STRING" id="590646.G3B6R3"/>
    <dbReference type="GeneID" id="18247366"/>
    <dbReference type="KEGG" id="cten:18247366"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="112"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="424" mass="48086" checksum="CA2CC8DEA1A5580B" modified="2011-11-16" version="1">MSQVFNSSSGSNADSTATTTGAATISKAGNIASFSPSSPLTAIDTYGNTFEVPDFTIKDILSAIPKHCYNRSMVLGFYYVLRDIALLLVAGYIANTYVPMIPSKLARTAAYAGYAYFQGLVSTGLWVLAHECGHQAFSNYGFVNDAVGWVLHSYLMVPYFSWKYSHSMHHKSTGNLARDMTFVPKNKQEYLKAKGAVDLDDLLEDSPIYTLVQLVVQQLFGWIAYLFANVSGQRLTNVSAMRKNHFNPNSVLFDRKAYWYILLSDLGLITMGFVLYNVYKRFGGFSLLINWVLPYILVNHWLVFITFLQHSDPELPHYEAHQWNFARGAATTIDREFGFVGEYLFHDIIETHVLHHFVSRIPFYNAREASEAIKKVMGKHYRHTDESMWVSLWKSGRWCQYVDGDNGVMMYRNVNGLGMGTKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6S0</accession>
    <name>G3B6S0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114313</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686795.1">
        <property type="nucleotide sequence ID" value="XM_006686732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6S0"/>
    <dbReference type="STRING" id="590646.G3B6S0"/>
    <dbReference type="GeneID" id="18247369"/>
    <dbReference type="KEGG" id="cten:18247369"/>
    <dbReference type="eggNOG" id="ENOG502QTCF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079416_0_0_1"/>
    <dbReference type="OrthoDB" id="5223508at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="302" mass="34669" checksum="CF6AF1E32108A392" modified="2011-11-16" version="1">MGNRTLKYGGKSGILPKPRAIFKSNPIKPMTEQEKAHHASIEQGYADSVPLPVKKGFSFHRKVEPKKVVTVEERIRKTIDERTPKNVDTTQLKDEEIWKLKVGDIRREHLRTAYLKEYERLKKIDELEAKRAAEAKQAEQSKQEYEETEATKLTLPTIESYLQGPIMRQRTPTEQALLEHKRAFNRKSRELEVKESRAEQLLGLYHQASSFVTTEAQLEKAITEAFEIRLNKFNLSAMSVKDRLNGSKDSNVTLSENEDAILDAAHGQINRKPGLNVVRDTIDGELEKLKRQAEIAIHNNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6X7</accession>
    <name>G3B6X7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARF/SAR superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_105980</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6X7"/>
    <dbReference type="STRING" id="590646.G3B6X7"/>
    <dbReference type="GeneID" id="18245855"/>
    <dbReference type="KEGG" id="cten:18245855"/>
    <dbReference type="eggNOG" id="KOG0071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="163" mass="18334" checksum="4089AC340ECA4855" modified="2011-11-16" version="1">MRILMLGLDNAGKTTILYKLKLGKTSQTVPTVGFNVETVKQKNVSFAVWDCGGQERIRPLWRHYFTGTDALIYVVDSSDLDRLEESKKELLRVISDKELSECLLIVLANKQDVGNAIKPKELIEKFELNHLPGNHVWSVIPTIAINGTGLVETLNWISNNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B700</accession>
    <name>G3B700_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature viability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_122786</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B700"/>
    <dbReference type="STRING" id="590646.G3B700"/>
    <dbReference type="GeneID" id="18248930"/>
    <dbReference type="KEGG" id="cten:18248930"/>
    <dbReference type="eggNOG" id="KOG2637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028555_1_0_1"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49695" checksum="91F4BBF065447D2A" modified="2011-11-16" version="1">MAPRRRFDKKNATTFSVVHRSHDDELYFDNDASRHVLVPVGGKQKPTKANTLSELEATLGDEAQSVRDNEGLAAQYGIYYDDSKYDYMQHLKPIGQSEDAVFIAKKDTPKPKPKQQDLMELLKDQLPSETGKKVTQADMENIPRELQGFKPNMDPRLRETLEALEDEAYIEDGEDDDDFFNDILKSGTAADIPEEEYDEWDMDNYQDEFDQYDSDNQDRTPYEVGDLERHELPYNEGEAPETAKNVVLNTAWEKDFERFKQTHHNSDDSDDSDDDFEDDFEENDQLPELKELPQMARVKKSGTKLRKKKGAMTDTSSFSMSSSAVFRSEGLTLLDDRFEKLAKDFEKDEAPEEYQEFRMEDERNDFEDMLDDFLDNYELEKGGRKLMKKNDEMKRLQKASDDASNTKVSRRRKEQEPSLVNQFAKVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B735</accession>
    <name>G3B735_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114399</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686880.1">
        <property type="nucleotide sequence ID" value="XM_006686817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B735"/>
    <dbReference type="GeneID" id="18247406"/>
    <dbReference type="KEGG" id="cten:18247406"/>
    <dbReference type="eggNOG" id="ENOG502RAA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1156248_0_0_1"/>
    <dbReference type="OrthoDB" id="4017073at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="240" mass="27400" checksum="84F78EA373928838" modified="2011-11-16" version="1">MSDPDFADTEYNDFMENLTPCSSLATAFSEEDAPVQYNPISFVNLLNKRNSLTKSGTLTDDSASISKFDLEKENCRIKILTPDDESFFIRIEELHSFINGYLPVPCTLDDLSIVHLLIFLSDRYSTTLNSIRLCHFGRSHAIKTFQDLTIKKQRLLIELKVTQYPTMHLIITKPESSPLRLISTKQAIEKTYSTGYQAVTYADAIAHKFRTTCLGSKSKQNLKVRMKYKLKSILQEVIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B779</accession>
    <name>G3B779_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_108321</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B779"/>
    <dbReference type="STRING" id="590646.G3B779"/>
    <dbReference type="GeneID" id="18246020"/>
    <dbReference type="KEGG" id="cten:18246020"/>
    <dbReference type="eggNOG" id="KOG2019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009165_0_0_1"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="17">
        <location>
            <begin position="517"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV61585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118453" checksum="FBE495171DC4F459" modified="2011-11-16" version="1">MLRRFTKLSSVGAQPSAPLSTQVRRSFATAYNQAKILNKYPIGLNYHGFTIEQVQPIPEFSLVAVKLKHARTGSQHLHLDAPHDRNNVFSVAFKTNTPNATGVPHILEHTTLCGSYKYPVRDPFFKMLNRSLSNFMNAMTGHDYTYFPFATTNARDFENLMDVYLSSVFEPLLTYEDFTQEGWRLENEVSDDKSSPLIFKGVVYNEMKGQYSNSSYYYWIKFQEAIYGSLNNSGGDPQKITDLQYEDLVDFHASCYHPSNAKTFTYGSLPLMEHLQKLAKCYEPFGARGVKNLIMKPTFQNNTDSSKNVAAINGPVDVMSGKAVAEQYKSSITWYLGDPLDEEKQYEIFQWKVLNSLLCDGHSSPFYQELIEKEYGDDFTVNSGLDSTTSLLSFTIGLNNLTKEKVDGLEEKVKQILQNKILPDFKSDSKVFRERVEAILHQIELNFKKHKPDFGLGLLHSIVSSWINELNPITSLQVEAVLQQFKNDYETNGLKMFEQLLENSLLNPNTPKFTFTMIPDEDFTTKLAEEEKQRLKSKVEVLEEEDKQVILERASKLAAKQQEEEDVSVLPTLTLQDIPRNGEFYRLKFGEVNSKKVQKRIVDTNGLVYATAAKDFGYLPTKYYPYIPLFISCLTNLAGTSQTSIIDLETKIQKHTGGVSFSVSNKTNPFNISETNLKFVATGMALQQNSSYIFELWKEILTETKLTNEPEVVDKLNTLVKNLGQNQMNSIAERGHSYSSAFSNSQLTVSKNIRNITSGIGQVEFIMQLNRELEAKGKDFLTTELLPTLNEIQDYVVGGFTKGSNPGFEYSLIGDAGAVSEAESLIQTFDDRMGSLKSLENENVLSGFTQGFSTSYPEVKTSTLINLPFQIGYSSLAKLGAEYTSMDGAVLQVLAQLLSSKHLHSVIREANGAYGGGMTYDGLGGTINFYSYRDPNPLKSVDSYRQTFQIALDKLESNWDAKDLQEAKLSIFQSVDAPSHVASQGVAAFIEGITDDMRQDRRERFLDIDNEDLKNVVDKYLVKAQKEVVTVIGDNSNLHIAPDGDWNIKSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7R3</accession>
    <name>G3B7R3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_95185</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688471.1">
        <property type="nucleotide sequence ID" value="XM_006688408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7R3"/>
    <dbReference type="STRING" id="590646.G3B7R3"/>
    <dbReference type="GeneID" id="18250485"/>
    <dbReference type="KEGG" id="cten:18250485"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006220_0_0_1"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="12">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="815"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="826"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="852" mass="97096" checksum="12629FEC704E6812" modified="2011-11-16" version="1">MFSITTINHKTQETHHPLLLLTNREGYKYLFGKVSEGSQRVLNENKVRLTKLKGVFLTGTLTGWSEIGGLPGLFLTISDATKKDIDVYSTSSAILSYIVATWRYYVFRKGVELKINDVDDGKLISDSNILVKPIKIASAHSAEADIMVRRQLKKLVSLMFPLDTSKANDRDPSSYKTDPADQDIQTHVSISDLELQAGSQKAMNYLIRFQSLRGKFNPVKAKELGIVKGTDFRDLTQGISVTNPQGEVVTPDQVVGEPKYFKKVLMLDVPNSSYLENVYKCTSWFEKNDSDLGQEDIGVVYHILGDDINFRSKEYIDFINSFPSDCKHIISHQELSNNTIVFKTFASNLLKLRAIQRDHYNLPCSEPYDGDGINKLHSMQQLNIGADGFTFDNSNIFDSNWSRMYDEHIEPLQIEGADKQTVIDPTPLPLGLTRGSLKDNVHITTLGTGSALPSLYRNVLANLVRIPIKNHETGEVEYKTILLDGGENTLGSLLRTFGHKDQYQTILQELGMIFLSHLHADHHLGLVSILNKWFEVNKYNDKVLHLVLPWQFNHFIAEWYKLETQTIDLSRINYISCEDFLHGRTPEYSKISIETFEEQFDRGNLKINIPRARLESIDFTSINKMYKDMNMVGLRTCRALHCYWSYSVSIEFQIDVNETFKVSFSGDTRPNPSFVEIGLGSDLLIHEASLDNELIEEAIAKKHTTMIEAVNVARYMNCPKLILTHFSTRYSNGANFVSGKEEFNRLSNELKTYLNTYKDVNNIFLLEDVINTPIRDFNDMEILFAFDSLITRLSQVGDQKTHMNRINKIFDSGSGDIDEKELDKSRAKREVKRAQRLSLQKKRKTSSDEEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8E0</accession>
    <name>G3B8E0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_95259</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8E0"/>
    <dbReference type="GeneID" id="18250491"/>
    <dbReference type="KEGG" id="cten:18250491"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="441" mass="47882" checksum="330FD9B0A7E45843" modified="2011-11-16" version="1">MGYEAKLQGLALKFRGMLDKFPNTHNIFVISIVTCTAGLMFGFDISSMSAFISTSQYRDYFNAPDSTLQGIITASMALGSIFGSLASSFVSEPFGRRSSLMVCGIFWCIGAIIQTSTQNVGQLIGGRVVSGFGVGFGTAAAPVLVSELCPRTIRGRVGGLFQSAVTVGIMVMFFISYGCSQIDGTTSFRVAWGLQLIPGIGLIFGCFCIPESPRWLAKQGYWEDAEEIVAKVQAKGNREDENVLIEVSEIKEQILLDRDAKTFTYADLFTKKYLPRTITAIFAQTWQQLTGMNVMMYYIVYIFQMAGYGGGALLSSSSIQYVLFVVATIPSLYFLDKFGRRPVLLVGAAVMMGLHFAVGAILAVYANPVDNIDGDDTLKLEIPDSRKAAAKGVIACCYLFVCAFGTSWGTCIWVYCSEVWGDSACRQRGAAVSTCALLTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8G2</accession>
    <name>G3B8G2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_95274</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8G2"/>
    <dbReference type="STRING" id="590646.G3B8G2"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467771_0_0_1"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF32">
        <property type="entry name" value="ZINC FINGER PROTEIN RST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="514" mass="56592" checksum="5BFB673DDB80123C" modified="2011-11-16" version="1">MSVKTQTKDKLEEPVQDSSGESSPSSATESPVPDSPDADAEADEADADDKKKKRTVKGRVFQCTGFPGCNMSFTRSEHLARHKRKHTGERPFTCPYCSKNFSRLDNLRQHKQTVHAYENYLATKKPEDKDEAAPPPGQQASQPPPHHVQHPQHHVQHHIQHHVQHHVQHHPSHHVQQHVQHHLPVQHPTSYPHHQPVHYYSPGTPNHPSLASPPNSNSPHHNYPHFQYQGAGAPPPFHAQSHSRPPASGPDVNTISSNEEEPPSNASGNSGGGLRLPSHQFKPKRRPRPLSLQHSFVLNSDKLSSMSSLSSSGSSTLNTPVYDRSYLGGGSMKSAPPVPMYSFSQHMNAPPSQQRSFPSKTMLQYSGPRSASLVSPLSPLYHHQPGHPSRSQPLQAHRPQTFSFPPGNPPTNGTGSLVLPPVQHIPHPSLHRSAHSMNSIPQDDVSTAGTTPTRGLDIAPIKDSTKSWLRGVLNDDDTSKKPTITSLLSPDNDKFQNGEVEKTKVTTQVKEEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8H6</accession>
    <name>G3B8H6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_126276</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688566.1">
        <property type="nucleotide sequence ID" value="XM_006688503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8H6"/>
    <dbReference type="STRING" id="590646.G3B8H6"/>
    <dbReference type="GeneID" id="18249159"/>
    <dbReference type="KEGG" id="cten:18249159"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="401"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="460" mass="51373" checksum="72C254F50EF88D78" modified="2011-11-16" version="1">MVSLSKLFSNSLIYSSSFHQAASPALDNTEQYNIAKFLVSAGPYFEYQGFGISTDLPVNCTLEQVQLFMRHGERYPTTGSGTSYNTTVQKIKSSGTLVGPLSFINDYEFYIKSSDYLEMLTTPENSNSPYLGSKTAMEAGIAFRSKYGILYNDNIPLPVFSTNSQRVYDTAHNFINGFMGEQFSSDQVKFNVISTNITQGFNSLTPTSACAKFNTSYNSEYINAFPKDFLSNILARLEVGNPTLNITTSDIGTLFNICAFELSNTGGSQFCGLFTDEELITNNYLTDLNKYFTQGPGNPLANAIGYVHFNASMALLKDEDSTNKMWLSFFHDSDLCHLFNGIGLFDTDSSMSNDRVKFHDDYQFTQTVTMAGRVIIEKFKYADESYVRFLVNNAVIPLKTCSDGPGFSCKLSDLEDLFESKYQNYNLTEVCGANTTYQQDLTFFWDWSSVSYNATTSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8N3</accession>
    <name>G3B8N3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688824.1">
        <property type="nucleotide sequence ID" value="XM_006688761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8N3"/>
    <dbReference type="GeneID" id="18247775"/>
    <dbReference type="KEGG" id="cten:18247775"/>
    <dbReference type="eggNOG" id="ENOG502SEQJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1740255_0_0_1"/>
    <dbReference type="OrthoDB" id="5277092at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="146" mass="16637" checksum="EB5142B79C0CD94A" modified="2011-11-16" version="1">MGWFSFNSKASSSTSSNNRVPGQVEQRSHQPLGLAPEQSDISHTLNQISDDQQALTVKEENAKSIQDFQKAVTEFVNKRPDNMFVIDGEREMKQSIICTNNENGGKTCLKLQYNSVQLFKQMQTLEYFCSLPDDIDATYFECRKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8S6</accession>
    <name>G3B8S6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_95315</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8S6"/>
    <dbReference type="STRING" id="590646.G3B8S6"/>
    <dbReference type="GeneID" id="18250496"/>
    <dbReference type="KEGG" id="cten:18250496"/>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110381_1_1_1"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="14130" checksum="DE23175D3D5FF24A" modified="2011-11-16" version="1">MAGLKAYELRTKSKEQLENQLVELKQELANLKVQKLQKPSLPRIHTVRKNIARVLTIINLNQRENVRAFYQGKKYLPKDLRAKKTRAIRRKLTKFEATRITDKARKQKTTFPKRSFAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B977</accession>
    <name>G3B977_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115279</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
            <location evidence="1 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B977"/>
    <dbReference type="STRING" id="590646.G3B977"/>
    <dbReference type="GeneID" id="18247801"/>
    <dbReference type="KEGG" id="cten:18247801"/>
    <dbReference type="eggNOG" id="KOG3174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045864_1_1_1"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="290" mass="32800" checksum="CA0BAAA0788AD780" modified="2011-11-16" version="1">MSYEDKFDSSLDLLRRLDPKHISLNLNTLCSIIQSQDSDSELVPDLLSSVDTPLKLITDKSNNKQFLSCDYNRDGDSYRSPWSNKYYPSSSVDDDELPPYPSDDLRQLEIKANESFDVYRDLYYENAGISSVYLWDTDEGDIPDSLNNGFAGVVLFKKEIDNGEGKWDSIHVFEVETAGSSTYSYKLTSSVILDLNNNKDLSVSGNLTRQFDVTKKFTGSNDTGANLETFHLISLGQLVENSEYTIRNLLQEVYFDKLKDIILKDLRRFGADDGQLQAKQSDLIKGLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9A2</accession>
    <name>G3B9A2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 1 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_125075</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B9A2"/>
    <dbReference type="GeneID" id="18249076"/>
    <dbReference type="KEGG" id="cten:18249076"/>
    <dbReference type="eggNOG" id="KOG1858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000746_0_0_1"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000435">
        <property type="entry name" value="Ubiquitin ligase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="5">
        <location>
            <begin position="655"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1548" mass="173454" checksum="889C0FFB02B85D79" modified="2011-11-16" version="1">MTSSPTPDQLSSPAIDLKYLRAYTSSGGQTKLFPGNKHLVIHKREVLLVNGASLSKKFTFDEDVVTATFTCFTHSESLATESEPSLVICLAKSAFIYTNGKDYTVSFPFVLRSALPFEFGLLLEKGQLQTYPSESGINSATFLSLVDPIGEFRVITSSSTSTISPYEEMVAFPLKGLNKTSSLCATYNRHDKVIVIYHIRTSNKNNGKRLNSFKYSKRKNTFLTTPNPARILEDESLHIDYSNGNMSNHMSITSSINMEKKRTSTLLSDASSMARMGSESSISELSKPMEMALKKDMILTRVEVLSIQVDRKNLDIYNLCYEEQEAIIIMNRYKKEAKVYIFNQSITAIPQYQSTYSIKCLHCVPLMNSEFPGYIVVLRESNVIQILNPFVDVTSAPITLSGQYPTISGLQCACDEDIALIGSDGDTFILKLVMKPSSDIVLKCLQCFKYLSGSNISETIWTLWRTALMLDDYKDDWWAFVVTILAILLPMDSEVSNYELNEITVLLPLAKKLNEQLNDDYLFREMLPYIAISLHLIREEAKLDVLAHDSLDKIGLFLTQLCTWMGWPEAWCKYYMVDINKIDGEPRMPSVFVIPQPPNILESLSSLFNDSIVQYLTFSQLVEESFAADELIIPRTHAILKLFELIVSPNYGPNNVVDLMCELGFTIQDLETFPLGVRVPLKEAISYCQENPDFQWNPKALDLVGRKELNMFLRSGSYQPPTSLYTQFGPNTNQLPRDINHILSGVLDGTEQVSAWDDQSEADRIGITKLIFDHDRRYYEITSLLHQTKAQTATLITEEGKSDFDVVVLQRALAAIVALRTLSIPLGRASLYYGGRMPLLTEKFPIPKFNLNTVVAPKMTNIVLHDGAVDEKVIEWGYFHNGVAAGLSISKQSKGISGSWIIFNKPPSLNAQHAGFLLGLGLNGHLKNLEEWHIYNYLGPKHPLTSVGLLVGMAASNMGTMNIKLTKVLSVHAVALLPQGANDLNVPVMVQTAGLLGIGLLYLESQHRRMSETLLAQITSTVSQNDSEQIHEGYRLAAGISLGFVNLGKGKDLKGLNDTRVVDRLLALATSMKDYQPVQELDKSCSGAIMALGFIHMKTEDVTIANKLGVPQSEQLLDYIRPDLLLLRCVSKNIIMWSSVNNTRGWVESQIPESLLARYGKGNADNLDSDQICYYNVLGGTCLSIAIKYASTHDKTARDTLLHYLDQMMVVAMTPTEKYDQKITCNAATNIQNLLALSISVVMAGSGDLETFRRLRVLYGDTSKDTNYGNYMAINMALGFLFLGGGQYAFGNSNLAIASLIVSLYPVFPNNNSEYEVHLQALRHFWAISVDPRCLIVRDVDTHKPSKIPVTLRLRNGQVKKATSPCLLPSLSSILSIQTDSLDHFKVRIDFGSNPDYLEIFKKALTLFVYKRQNYQMLKSSVKNLLEYENRSLQVENNEVKVDKDIEKILSLNFMKPISAHEKKVYLYESSSLSNDTSLNDLGLSVFIIIDTKLELQRVASNPKAVDDLMNLKLIFSYSDKLFSDDMRHIPLEFVEMLKHSVWELTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9D0</accession>
    <name>G3B9D0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_136418</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688645.1">
        <property type="nucleotide sequence ID" value="XM_006688582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9D0"/>
    <dbReference type="STRING" id="590646.G3B9D0"/>
    <dbReference type="GeneID" id="18249973"/>
    <dbReference type="KEGG" id="cten:18249973"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035475_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="58910" checksum="7E1703902475AA46" modified="2011-11-16" version="1">MDRQSILEQKRKRLEELRQRRLANNDEKYADNAVKEEAISKVIRVDASVQTQSDSPFRSNATSTINSLEITKFDKAVQTVNSTPNHPVQTSLIEVKDATQKESLDSILLDLNVNEKDLHSSLKSAVTLLHEVLATSIEPSVDSPAIQTDEEKGLIFVTTEVHAIKNRVPISIEVSTTPNEFLVNFNNNELEEFPGFAVIYRNLNGKVIPMKFLASLSPINCIKFDEFSPSKVIGGLTNGRVVIWELAESSGEDAVILPTLMSPSDYSNGNLHKVPITSISQISTEPNTFITTCLEGLINVWSTNFLEYPQFEGVSLPNNTEESLGILEQPFKSIKHAILLENGDKNVLKDHKFLNSMIISTETHGVHQLINDSKLGYIKSTIETKIVGSMTNIGYKDDSSLTALTCYDSNIYILNNHKKILKIATDYMVLGLFKRPTTQFQFVTFGLFDELEDKLTTVIDFWDLNVNTRSPLFSLRRPSSNHPTSGNFEKEGNIFYMGSSDGILSVLILDTNFITKGNNNDTIHEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9F4</accession>
    <name>G3B9F4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_135800</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9F4"/>
    <dbReference type="STRING" id="590646.G3B9F4"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="64"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV61871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="461" mass="50298" checksum="5479D472EED41450" modified="2011-11-16" version="1">MVQITDVKDGQVREARTAAHTHIKGLGLDEKGVAKRIEGGFVGQSDAREACGIIVDLIKSKRMSGRAILLAGPPGTGKTALALAISQELGPKVPFCPIVGSELYSAEVKKTAALMENFRRAIGLRIKETKEVYEGEVIELTPEETENPLGGYGKTISHVIVGLKTAKGTKNLRLDPSIYESIQKERVTIGDVIYIEANTGTVKRVGRSDAYATEYDLEAEEYVPLPKGEVHKKKEIVQDVTLHDLDVANARPQGGQDVLSMMGQLLKPKKTEITDKLRTEVNKVVSKYIDQGVAELIPGVLFVDEVNMLDMEIFTYLNKALESSIAPLVVLASNRGLTTVRGADDDIQAPHGCPPDLIDRLLIVRTLSYTQEEVRAILGKRATLEGLVVTPPALDRLAEHGVNTSLRYSVQLLSPAGILAKTSGRQEITLDDVEECEVLFLDSRRSIQVLEQATGFIEARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9P8</accession>
    <name>G3B9P8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_135869</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9P8"/>
    <dbReference type="eggNOG" id="ENOG502RQDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1644761_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="153" mass="17336" checksum="9CA571C0C23AA60A" modified="2011-11-16" version="1">MSLSLKPKSNRLKNVTITSAVIVGASLVILNTFPHLKQSLYDYFTQSKDGSDEEDVNAPIELSSEELAEGDKVSSKDIAEESIVDVNEWSNDDLKSWLKKKKSTLPKMLVILTLFPLLSQSKKILTNQFILDFTVLQCLVKLFFIVQNFILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA19</accession>
    <name>G3BA19_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor ISY1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pre-mRNA-splicing factor isy1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_107484</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA19"/>
    <dbReference type="STRING" id="590646.G3BA19"/>
    <dbReference type="GeneID" id="18245954"/>
    <dbReference type="KEGG" id="cten:18245954"/>
    <dbReference type="eggNOG" id="KOG3068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043453_2_1_1"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="277" mass="32170" checksum="6972CE2F151F2AFF" modified="2011-11-16" version="1">MSRNKEKAQSALNRYQQEVNRQAGVLETNPNLRPKYVQSVESLPQAEKWRSVVITEISTRLTRIQDPLLEESQIRELNETLNKLMSEKRAWEHHIKSLGGADYLRFGPKFESMGMMDNDISGIKGFRYFGRAKDLPEVKLLQQAKIDKATRESTQQDTEQREVQELEMRFSNLDPTYYSTFTRTNIYDKAEDDLIAIVGDVYTRQEERKNVEAYNFKAISKSLSDDIQNTAKDMTISQAQLEEIMDYSDIIPSEEDIKQWVLDQKKQQLLAKLASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAP9</accession>
    <name>G3BAP9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_94963</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAP9"/>
    <dbReference type="GeneID" id="18250461"/>
    <dbReference type="KEGG" id="cten:18250461"/>
    <dbReference type="eggNOG" id="ENOG502RZDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042558_0_0_1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12410">
        <property type="entry name" value="RRM2_RRT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034247">
        <property type="entry name" value="Rrt5_RRM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="137"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="331" mass="36193" checksum="FBE6C0D0E5FBDDD4" modified="2011-11-16" version="1">MSTDNIVQIKNVDYYGTEEELTAFLSEFKLKKVIILNYTVAYRTDKRRPLGVAIVEFVDADEAKKAVKLIHGIKFRGRTISAKLHVPFVPKPRRRMTVKKDGEQKEEEKSVEVDQADDRLTQTSREPTYGPPEVSTDTVYIVKIKADSTDNQIREFFQDYSPQEVFVFTERAKKRGLFSRNHKSALVSLKTEKLLEEVIGSLKGKALNGKKVELKAAFMPKVRKVKAADQKRKEALAEKSVEGEEPEPEAPEESLEVPAGGSVSVGTREVEGEQGVSSGTTVVETSATITEATAVESDETVSGEGCGTSVGPVGASVGEATVATTTFTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAX3</accession>
    <name>G3BAX3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_135424</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAX3"/>
    <dbReference type="STRING" id="590646.G3BAX3"/>
    <dbReference type="eggNOG" id="KOG0524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="119"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="446" mass="48157" checksum="ACD30A97EB3E1957" modified="2011-11-16" version="1">MAKYHRPGGAHSPRRSPKDPPHRPGKLNSGRVPPPVFTLPLSQNLSSLTRKILDLSTHNMVSKIAQTAHLAAQASKVLSPVASRSTNPSAALKLAGAAQSLRMMGQVRPASSEAGPKTMTVRDALNSGLAEELDRDDDVFIMGEEVAQYNGAYKVTRGLLDRFGERRIIDTPITEMGFTGLAVGASLAGLKPICEFMTFNFAMQAIDHIINSAAKTLYMSGGKQPCNITFRGPNGAAAGVAAQHSQDYAAWYGSIPGLKVVSPYSAEDYRGLIKAAIRDPNPVVFLENEVAYGESFEVSEEALSPDFVLPFGKAKIEREGSDITLVAHSRNVKFCVEAAEQLHKEYGVNAEVINLRSIKPLDVPTLVESVKKTNHLVTVEAGYPAFGVGSEIVAQIMESEAFDYLDAPVERVTGCEVPTPYAKELEDFAFPDTPTVFRAARKVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAZ1</accession>
    <name>G3BAZ1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_98701</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAZ1"/>
    <dbReference type="STRING" id="590646.G3BAZ1"/>
    <dbReference type="GeneID" id="18250797"/>
    <dbReference type="KEGG" id="cten:18250797"/>
    <dbReference type="eggNOG" id="KOG3144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069429_2_0_1"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="233" mass="25686" checksum="FCD7C934095D7325" modified="2011-11-16" version="1">MPKQKRKVKFDHDDTEDQEAVVVARVPTIIHKWATIPYHLPLILVGMFKFGLTSHVKQTLVKGYISLICLQAVHSYILYINTVDFPDSSSGKKHRKKNKDNLVLLIASSLVLPVLMSPAVLAILVLLGAPVSSHVIETYLLAAHLSTVVATPLLVTFKLNFANFVSVFKSPDLFCVVCHHQTLSSGLLALVGTWIGVLPIPLDWDRPWQAWPVTLVVGTYIGFFGGSVINLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBG9</accession>
    <name>G3BBG9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_131587</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBG9"/>
    <dbReference type="STRING" id="590646.G3BBG9"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_2_1_1"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="335"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="398" mass="44079" checksum="82F4984A40FD9A10" modified="2011-11-16" version="1">MSYSHPCKKIVDASDLSAFRRSIAYSNIQEAIHSILVLVKSHELPRGILNLKLVSALKCEHATETYTIQCPNGQRVLNSLAYFDSVIENFPPLPGPRRFGNYAFRDWYGQLEDSAAGKLQELDILNTNKAGFLSELSYYFVAAFGSGIRLDFGTGHELSFVAFIGSLLKADALKNITGQDILVIFARYYDLVRRLILTYSLEPAGSHGVWGLDDHFHFIYILGAAQFNEPVSRYAPPVSQCLNEGTISEFLDTNLYINALAFIQKIKSGPFKNHSPLIYDIHTSVTLWKKVLSGLLKMYDVEVLGKFPVVQHFWFGGVLYPWKDENLKDLPVKQEAEKEKENVPTKVLPGVPSTGVSTGAPAPFSSTNISTSTSTPPSSSGTAPTRMPPPRMPPGSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCL6</accession>
    <name>G3BCL6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_99696</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCL6"/>
    <dbReference type="STRING" id="590646.G3BCL6"/>
    <dbReference type="GeneID" id="18250874"/>
    <dbReference type="KEGG" id="cten:18250874"/>
    <dbReference type="eggNOG" id="KOG0319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009276_0_0_1"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="360"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="462"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="546"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="6">
        <location>
            <begin position="641"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="777" mass="87258" checksum="3A070CD9748CEB5C" modified="2011-11-16" version="1">MDLRTEYSNVDIDPFYIGSNACSVSEDGQLMASANFEDIVITNLATNEIIDQIDGDGELITNLILAPNGLTLGIISQSQNLRVYDVESKTIIKSFKMSSPVYVSAHDSTSSLFAFGGTDGVITVWDIEGGYVTHSLKGHGSIISSLCFYGNLNSKNWKLASGDTQGVVKIWDLTNRKNTHTFKEHASAVRGLSFTKSGQYFLSGGRDEIVVLYKDLKPIKTLVVKQSIEVAGFLDTQADSTELYFFTAGSDNLLKIWDADGETLVNQTKNYQTEEELVIVDAIQIENEQMYLVVSDQTLVKLDLSEFHTQLPVVSRIAGNHGIIADVRYVGPQFDRLALATNSPSLRIVDPQNPLSVEMLEGHRDLLNVVDVTIDGKWIATGSKDSEVRLWRYDEEVQRFKAYAVFKGHVGSVSALGLPRTPVNEYPRFLVSAAGDLTIKKWKIPKPAGDEVQVVKSSEYTRRAHDKDINSIDVSPNDEFVATASYDKLGKIWHLESGETIGVLKGHKRGLWDIKFSPYDKKIVTSSGDKTAKVWSLLNFQIEQNFESHTNAVQRAKFMNKGTQVISTGADGLIKIWDSKSGECLKTLDNHSNRIWALDIANDGLQFVTCDANGQISLFDDNSEEMGKLKEDEQKLKIENDQRLNNYISQGNFKNAILVALELNYSMKLFEIFTKIFENNQHEELIDILTQLNDVQLVSLFTKIKNWNINFKNFEVSQNLLYLMLNHLSLDKLNSSKLMAIIDSLIPYNERHLNRVENLIEESYILDYSIEQMNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCR8</accession>
    <name>G3BCR8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_110826</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCR8"/>
    <dbReference type="STRING" id="590646.G3BCR8"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013294_0_0_1"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="13">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV60865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="435" mass="49343" checksum="FC2F2E933C3D49AA" modified="2011-11-16" version="1" fragment="single">MPQNSFGGKLLEFPDIAVDKFNVDAKIFLLSHCHSDHLVGLANKSFQSTVYCSELTKQIFSLDNRNAPWLRYLRGIAFNSPFSIILNDKKVVLTLISAYHCPGSAMFLVESEEKNVLFTGDIRAETWWTMGLKKNMYLFPYTCGFKSLDCIYLDTTFGYRREPYIEIPPNTDGIAAAIKMLSLYPTDDPDIEFFFADHTLGFEQAWSMIVSSLGGSMHMSNRILQRSVVVSKNPNCETYESVLGHFDTNGGQKFHACEEGFCSQKVKFPVRIKQCINLNVIDFVGCLLPVDMKTLTDKGKQGIQVVDYTTKGNAIVRYRGRTWIQVNNELLPSEIKLVFSRHSSYSECKEFVKTFNPVSVYPCVTSKGTWENGFVMSRLFKDVCVSGGIENFAFDVINCATHGIPISPIMVRPVKTINRWDLQDCENELRFVAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCU6</accession>
    <name>G3BCU6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_110157</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCU6"/>
    <dbReference type="STRING" id="590646.G3BCU6"/>
    <dbReference type="GeneID" id="18246173"/>
    <dbReference type="KEGG" id="cten:18246173"/>
    <dbReference type="eggNOG" id="KOG2397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016834_2_1_1"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="6">
        <location>
            <begin position="370"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="493" mass="55385" checksum="DE85FD1853C00AD7" modified="2011-11-16" version="1">MKSSIILGIYAVCVVEGHIMGVSPEKQHLYEPITGSNDADKKWRCLGDPSIVIDYSQINDDYCDCPDGSDEIGTNACKFNQSNMFYCANDGHIPGYIENFKLNDGTCDYDRCCDGSDEYITGNCPNKCKEIHDQYVMYEALMEEKVRLAASTNTKLKQDAIALKDRVEAKLESFRQENVNLVDKLTQLEEAQAHGFVGTQELSVYDEISSYTNKVAEKAADLEATHASTSQRAKKLEAILHNLLTNYNPNFNDAAVKEAVNKFQDYLANKEDSDDVSGISSDLEQLNEYAKTVMVGESHYSSPETFDHTVPTFGNMIHYYITKIFRLFDAEAVDQLVLKHIKTPEGLDVEIDSTRKGISTLNKNIETLEADLAADYGPDDILRALVGKWVNTNIGGYEYKVGLLNQVYQDGNLLGVYSHYKDGKLYYINGHRCWNGPLRSAVIEFICGDDQQVLSIAEPEKCEYHIQVSSPLSCQKMSQSDIQKSFKIDYSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD22</accession>
    <name>G3BD22_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_96335</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690114.1">
        <property type="nucleotide sequence ID" value="XM_006690051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD22"/>
    <dbReference type="GeneID" id="18250603"/>
    <dbReference type="KEGG" id="cten:18250603"/>
    <dbReference type="HOGENOM" id="CLU_2026417_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="122" mass="12670" checksum="CA0B0327B875299D" modified="2011-11-16" version="1">MVFGLGHKNSSDSSSSSSSDEEHQKISQDQKLKDTKKKESKTTQSARSDPYVSGGGDLGPNTDTYGRDSYGGAGDGGRNNFDSDSYGRNSHNSGNTSHSGGSYEAGTGADTGGRDNPPHGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDH5</accession>
    <name>G3BDH5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_110367</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDH5"/>
    <dbReference type="STRING" id="590646.G3BDH5"/>
    <dbReference type="GeneID" id="18246189"/>
    <dbReference type="KEGG" id="cten:18246189"/>
    <dbReference type="eggNOG" id="KOG2987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032156_0_1_1"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="10">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="373" mass="43284" checksum="38B4E208C72AEBD4" modified="2011-11-16" version="1">MSSITHRKANKTFTFTTPAADASIEVLNEFYWTNELEPHFLRRKHILAKHPGVKKLTGHEPLTKWLVILVVILQVSTAYYLKDTHPLTVKFFLLSYIIGATANQAIFLAIHELSHNLLFRKPLHNKLFAIAVNLPIGVPYSASFQPYHQLHHKFLGDEYLDTDLPTKLEGMLFSNVLGKVFFTTCQIFFYALRPMFITQIKFTYIHLINVVYQIGIDYLIVTYWGWHSMFYFLMSSFLAGSWHPCAGHFIAEHYVLNENNIPKLEAKGEASKTYVPKELLPAETYSYYGPLNWLTWNVGYHNEHHDFPYIAWTRLPKLRAMASEFYDPLPQVHSWTGVIIWFVLNDVNSLWNRVKRSGKEKSGKKVGRLDVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDK6</accession>
    <name>G3BDK6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_136803</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDK6"/>
    <dbReference type="STRING" id="590646.G3BDK6"/>
    <dbReference type="GeneID" id="18250003"/>
    <dbReference type="KEGG" id="cten:18250003"/>
    <dbReference type="HOGENOM" id="CLU_067891_3_0_1"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="9">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="146" mass="16984" checksum="D3E10B1BEB5B101A" modified="2011-11-16" version="1">MSYKGIELKSTRGSGTSGYVTKNLASLGDKIAYEDSKERVRKVKNRRRCWSENNQMDSIKARFRNELESRESLRDIEKKCMELRDKLENEDMEAAIVDTKVKELRDKLMNQSEREDEIRSAKDKEASEGGIKKQNYMKELQIIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDP0</accession>
    <name>G3BDP0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_95797</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689561.1">
        <property type="nucleotide sequence ID" value="XM_006689498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDP0"/>
    <dbReference type="STRING" id="590646.G3BDP0"/>
    <dbReference type="GeneID" id="18250541"/>
    <dbReference type="KEGG" id="cten:18250541"/>
    <dbReference type="eggNOG" id="KOG3330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="190" mass="21708" checksum="A3BE7090204CC7A6" modified="2011-11-16" version="1">MSKNSKFSADDIWKNNIDKINSELFILTYGSVVSQLCKDYNQEYAQVNKELEKMGYNIGIRLIEEFLAKTGIQRCQTFKETADVISKMGFKIFLNIQPIIANWSPDGKAFSLILIENPLTEFVQVPLTGGMAKELWYSNVLCGILRGALQMVQMDCECWFIKDVLRGDEHTELRLKLNKILKDEVPAGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE00</accession>
    <name>G3BE00_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Rhodopsin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTEDRAFT_110030</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell projection</location>
            <location evidence="16">Rhabdomere membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE00"/>
    <dbReference type="STRING" id="590646.G3BE00"/>
    <dbReference type="eggNOG" id="KOG0326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_30_0_1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
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        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
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        <property type="entry name" value="XYPPX"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02162">
        <property type="entry name" value="XYPPX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHODOPSNTAIL"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="23">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="241"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="410"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="18">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGV60420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="501" mass="56214" checksum="14317FD1B5FB42DF" modified="2011-11-16" version="1">MSETDWKSSLNLPEKDTRPQTEDVLNTKGKSFEDLGLKRELLMGIFEAGFEKPSPIQEESIPIALTGRDILARAKNGTGKTASFVIPTLQMIKPKVNKIQGLILVPTRELALQTSQVVRTLGKHLGIQCMVSTGGTPVKDDILRLNDPVHVLVGTPGRILDLASRNIADMSECSLFVMDEADKMLSREFKRTIERILELFPSNRQSLLFSATFPLAVKSFMEEHLNKPYEINLMDELTLKGISQFYAFVDEKQKLHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCYYSHARMPQQARNKVFHEFRMGKVRNLVCSDLLTRGIDIQAVNVVINFDFPKTAETYLHRIGRSGRFGHLGLAVNLLSWDDRYNLYKIEQELGTEIKPIPSVIDKSLYVAENESSVPKPFSTAQNGAPPQGYPPQAYPPQGYPPQGYPQGYPPQGYPPQGYAPHGVAPQVNGYPQYPQYGYPPYNGQYQQPMAQPQPSTQSSPTAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEC5</accession>
    <name>G3BEC5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_110430</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEC5"/>
    <dbReference type="STRING" id="590646.G3BEC5"/>
    <dbReference type="GeneID" id="18246194"/>
    <dbReference type="KEGG" id="cten:18246194"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="205"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="382" mass="42826" checksum="6FBD23D17880849C" modified="2011-11-16" version="1">MEYPVKSTPQQLTDFDQIIQAKINDARNEARTLYTEVENVKARMRDSTLLEQSVKLKPIPNHSINPKLYHTLEGHQNKISNVQWSSSSDQVLSASQDGYMIMWDPVTGLKKKAIELENQWVLTCALSPNSEFIASGGLDNNLSIYKVNDTVQQTYFNSKVQHVFKSHRAYISDCEFINNQQVITGSGDMECIMWDLNKGDKIRNFNEHTGDVLCLDTLPSGSSSLFISGSCDGYCKIWDLRSKSAVQSLFISNYDINTVRVFPQGHSFITGSDNGIIKLFDLRSDCELSKYSLSNQLDDNKRKSISSIDSVNVLSVDFSKSGRLIYSCYSDFGCLIWDTLKSEVVGTIGGGHQNRINQVSVSPDGIGICTVSWDYTIKVWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEK7</accession>
    <name>G3BEK7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 20">Mevalonate kinase</fullName>
            <shortName evidence="20">MK</shortName>
            <ecNumber evidence="3 20">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTEDRAFT_116648</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="18 20">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 20"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEK7"/>
    <dbReference type="STRING" id="590646.G3BEK7"/>
    <dbReference type="GeneID" id="18248386"/>
    <dbReference type="KEGG" id="cten:18248386"/>
    <dbReference type="eggNOG" id="KOG1511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_0_1_1"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000027">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 20" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 20 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="23">
        <location>
            <begin position="3"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="21">
        <location>
            <begin position="125"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="22">
        <location>
            <begin position="299"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EGV60568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="428" mass="46550" checksum="1EE27384AC6298D9" modified="2011-11-16" version="1">MDKPFFVSAPGKVILFGEHSAVYGKPAIAAALSLRTYLLVTPNQDPESIRLDFPDIQLSHSWKKSELPFEQSKPFIQYEEGLPKVSTELIPEIVDKLSILLADMNNTFHYKACISFLYLYLHLCGADVAGVTMTVRSTVPIGAGLGSSACVSVCLAAALSMIGGHITKPPFGLREKADATDVKELDFIDQWSFIGEKMFHGNPSGIDNAVATHGGAVMFQRMTNPSQPSVRTTMRNFPPLKMLLTNTKVPRSTAHLVSDVSRINSEYSKICEPILDAMGSISTTAYQLMIEPNFDELHKQKLRQLASVNHGLLVALGVSHPALEQVKMIADIEQIGVTKLTGAGGGGCAITLVDDSVAEEKIQQVISQYTAKGFECYETSLGGKGVGALFMDDCNHAVFAADAFAKFGTRADIEQALHFDVVGDWKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEM5</accession>
    <name>G3BEM5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_131834</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEM5"/>
    <dbReference type="STRING" id="590646.G3BEM5"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV59928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="377" mass="42407" checksum="D2A973EFDA93CD4F" modified="2011-11-16" version="1">MRLPNRADLWGGYWPFQGINTFAHLESHNCLLEPEQHYDIAVIGVPFDTATSYRPGARFGPRAIRTASQRQTSLRGFNQRAMMNPYQNWAKIVDCGDIPVTPMDNELAFKQMTMAFEELIYRRDANSTLAPPRYVALGGDHSVLLPHLRALHSIYGPLNVIHFDAHLDTWTPEGYPSYWHSDQSELNHGSMLWKANQEGLTSTHNIHAGLRTKLSGVEDYISDDEQHFERIYADDIWVEGVKYVIDKILDTVPKDTPTYLSVDIDVLDPGFGSGTGTQEPGGWLPRELLYVLRAIDGLNIVGADVVEVSPAFDNAEITATNGAQVAYEIITSMVKKGKTDDLVKNNTPQTTAKMTNHQFINEEETISKKGIKRYEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEP2</accession>
    <name>G3BEP2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_109952</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689155.1">
        <property type="nucleotide sequence ID" value="XM_006689092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEP2"/>
    <dbReference type="STRING" id="590646.G3BEP2"/>
    <dbReference type="MEROPS" id="M01.A25"/>
    <dbReference type="GeneID" id="18246159"/>
    <dbReference type="KEGG" id="cten:18246159"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="248"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="545"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV59941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="895" mass="101258" checksum="3C55D6ED1CCDD502" modified="2011-11-16" version="1">MSSPKPYYDALPSAFVPTHYDVAVYDIDTEANTFSGTVKIVLDVKDATDELSLNYRSLVVKAENVLIEVPGSQETIIRAVSVTEFAKKDFFVIKLDTTIDPIKIPQIVATIKYDAFIQTNMTGFYRSEYTEGDVKKVMLSTQFEAPDARRTFPCFDEPALKATYSVSVTITKQWTVLSNMPVATVSDAGDGLATHLFQKTPRISSYLVAWACGDFEYVESFTQEKYLDDKPLPVRIYTTPGYSKNAQFALEIAPKVIDYFSRVFEVKYPLPKMDLLTVHSFSHNAMENWGLITYRSNALLFDEETSDASFKKQVCYVVCHELAHMWFGDLVTMKWWDELWLNEGFATWVGYIAVDYLFPEWNILNMVTHESLQVSLTLDGLRSSHPIHVPVVDAVDVDQIFDAISYHKGCSIIAMLSNYIGKEVFLKGVAKYLQENQFGNGSTANLWDAVGEVSGKPISSMMNHWVTKIGFPLINVELNGKDLVLTQSRFLSTGDVKEEDDTTVWWVPLNISCGLEDDAIVEDIAVDSFESKRVVIGNFPTGDGFFKLNKNSTGFYRVNYSQEVIDKHILPYMDKLSPRDKIGLFSDVAAVAISGLGSTSTVTLLTLIKSIVDADQLGDDYGVWLGLNEILGKLRVVFSGDEEVCTGIDSFLRFVYRKLGAELLQEVKSNHDLSETDFRKVILITTVFSASGGLGVPEFVEYAKESFETWKNTGKIHPNLTFFIFSTMAGLEDLQQEDFDRIVKEITDPSSLDSREQAVKSLPSISNMKYVEPLLGMLKDTSIVPLMDSHYMAEAFTLNRKTRDRFWSYFKENYGDIHAELATNVPILERFIRFAFVNYQSEEMYKDVEEFFAVKGITGFERSYRQAVDTIKTNNSWYKRDLGVVKQWLSQNGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BER6</accession>
    <name>G3BER6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_110754</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BER6"/>
    <dbReference type="STRING" id="590646.G3BER6"/>
    <dbReference type="GeneID" id="18246221"/>
    <dbReference type="KEGG" id="cten:18246221"/>
    <dbReference type="eggNOG" id="KOG1877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333688_0_0_1"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="722"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="871" mass="97465" checksum="E3BEFF783FC1422D" modified="2011-11-16" version="1">MPGLFLPKHQKLILQCYPPGKGVEKKPNPSELSYLLYYASTRRVKLEKVITFLNKKTVGDSNRNRFGNIQVTLTLVSSLIEKCVDNLNVFALQAVSILNSSLKGNDLTLAKAVLDTYGVLCKNLDRGLFAGDKEFVNSFSRFSQTLIDTTMKSSAKGGPNSWEWKLISLLACRYLSGCLSNSPEISKSMLHKIIPILIDTFFENDHERILSGSLSLDGESVKLSKIHTSKTIVSAKRITEDLENGLVDENDLYMESIAALKSVFNTSLTSQLIEATNEVVGYTFQDSRITSEWSERFLELCVTWAPVQLRFVLLDTLVFGLKKVSSNVKLQQHYASHIFGLVSSNVNMIGLSISDFIQSILELKESLYFKDDSKISEEDKIHLSDIFSKSIINLSTHIYYSDQVPDSVYEIFFKIESTLDLSPQQDTTKLFDYVINLLSDIDAIFVKLHESSSSDSVINRNHVALDQWQISLPLISQKHAVTIFNSLSEEQVEQIQMVYLRIFDKFVDYELTTGTSPDSSQISGKPDVDDFLTPDYKELITESTNFLSHYLVYLDKYLNKNENLSLPIVQQLLMISKKIARVFGINFLNNYIPFFFHWYVNDFEDASRFDIIKDTFASALLKDCITIIDKKYSHELEGYSQRSEFSKNLDQNISYKIKNSLWASDLDASSASDYPANFVRLTSNDMGEFIKGNKFLSEWLNAQKPLILSVLHDEVLGESINGGTNGSHTNGDVSNGNGHSINEYHDARDSDGPPLTVNSDVSDVKPGLGLGTLADIASIHSGLRNTTFNSTLSNNSFDITNGSIVTNDKLTPPKVSDLKGMISSFKSSMKKPGQLKQDNSVTPGSVLSKQMATHDLDSIIDGLDDDESFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF27</accession>
    <name>G3BF27_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_137093</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689828.1">
        <property type="nucleotide sequence ID" value="XM_006689765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF27"/>
    <dbReference type="GeneID" id="18250037"/>
    <dbReference type="KEGG" id="cten:18250037"/>
    <dbReference type="HOGENOM" id="CLU_349490_0_0_1"/>
    <dbReference type="OrthoDB" id="4096032at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="806" mass="91176" checksum="B6E607B43A4E0AA0" modified="2011-11-16" version="1">MTPRRSDHPHGADTPVAHWSALDQIVHTLINSLPQGETNPSSQQTASAPGSNITRRASESDVLDPISFTDAHILSEYDRHVARRLDVGWGSGPSSSPYDQIVSGATPVSTSGSIMVPNLGARSQEDRSTTGRLHSVGGFFHGIEHQFSPEVSSRPTSSRAVAGPRRRPRRSITESFERRHLSATENPISLLDSRPPPATTSFELMRPDAFDTLLGSINDNWGNSERQHINDINSRSIDELTRSETRRAGLNRRNAIRRSVPHIDRFKDTSRAFFKTHTKDLLKVQKELRRANFNNPLLRCFKNHMNQRFLGNNYVSKMNSTLAKSRSGVLFTTKKRTISAKKNVKRRRTNTEATWPGSHVEEDDDDSSIDKESNSDHLKQHLLNIPFNSYLSIGSSFDFQFGASEANMFVLDVNYQTKEIRIQITILPNPETCSWYIGDITKFLMFFAISELEENLEIRKKLDTLLDILRQISPNDSVVQKMKSNLFKFEVSGNLIDFNQYDLRTSNNLSSNRQLNKWLTMPPFRYLVIPHTKSIIDSFNPKIRSEGNTEKEFKLMFSGLCNIVEYGLIKSPKIMALAKSMADEMEGFCRHYTGTDFNMISTRRTSSLLDKAVNLITCKNCLIHLQTAFIMFNLSLDLSEIYNTLYRYVVNFLPQELKKKECVNQFKSSSTNNKFLIFLGSLNRKNGNLSLLKTNILLNSNNTKPTDINGESDHEVTLRDTISHILAGEADSESCSGVDDSDMSEDNETDNDENDNDDKETKGLNDDNYDYDRLNDHTGDLMTATFTRQNKNPYSSGGGHQTSAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF35</accession>
    <name>G3BF35_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_116695</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF35"/>
    <dbReference type="STRING" id="590646.G3BF35"/>
    <dbReference type="GeneID" id="18248405"/>
    <dbReference type="KEGG" id="cten:18248405"/>
    <dbReference type="eggNOG" id="KOG3389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077196_2_1_1"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV60623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="158" mass="18017" checksum="BD1F086B88725F15" modified="2011-11-16" version="1">MISFRTLVNSSSRSVGVRSFMVSAPVRKLTPDLYNPQVPKEVVSGAPDSVTSRVVRIYKPAKAATQSSNNDGRSWRIDWDIVGKSNRWENDLMGYQGTADVMNATSLRFDNKEAAIRFADGQGWDYYIYEPKERKFRKKDYSANFYHSAGPLKHIRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF36</accession>
    <name>G3BF36_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 14">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_128029</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 14"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF36"/>
    <dbReference type="STRING" id="590646.G3BF36"/>
    <dbReference type="GeneID" id="18249278"/>
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    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="Post-SET_dom"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
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        <property type="entry name" value="Set1_fungi"/>
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        <property type="entry name" value="SET_assoc"/>
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        <property type="entry name" value="SET_dom"/>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF21569">
        <property type="entry name" value="SET1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 14" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="8 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 14 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="895"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="1021"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="341"/>
            <end position="388"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="590"/>
            <end position="662"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="675"/>
            <end position="703"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="832"/>
            <end position="860"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="56"/>
            <end position="77"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="341"/>
            <end position="362"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="368"/>
            <end position="377"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="594"/>
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    </feature>
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            <begin position="686"/>
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        <location>
            <begin position="847"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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            <dbReference type="ARBA" id="ARBA00012182"/>
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            <dbReference type="ARBA" id="ARBA00022454"/>
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            <dbReference type="ARBA" id="ARBA00047583"/>
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            <dbReference type="ARBA" id="ARBA00049129"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50868"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV60624.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1037" mass="118663" checksum="B3BDC0715CF28CFC" modified="2011-11-16" version="1">MSYNNYNYGYGHRHKPQENGNGYGAHPNSIKKSYGSSYHPENKPSSGNGRAFTWSPFPQSPQTNSIASRATSASHSPRTVAHERLPIAKSLNVAKNELSGTDVDTGINSHDEKFPTLMIHSNYLGKLEFSTPVDSSKTFKVVYDPELDKTLSKAEKKSKHAKLKFRDLKTVKSFDPRLTFQGGLDSYLNKPNKRSKKFPFKQLPQTKFVYNKDSLGPAPLTEIVIWELPTTVSEIYMSNYFKTYGNAIKDLKFINDSVNGVPLGIATFEFQGKLEKSARLADKVIKDSKESGIKMDGVQVKVGLNDHDSNFLNGKIRAAEAKLKASLFKLQEEKKKRAKLFEEEQKRQKSEEQKRQKLEQQKAHSPNKLFQVTTQKEPSTKPKKQKSNITITSIVHKNKVVSGVFLPTDLNRYIKDRPFIFIRDKYIPTKRIASSDIKRVLNKYSWTRVLSEREGFFIVFNSLKECERCFYKEDGVKFYEYSMIMEMCIPEGFYSDSNNEIGRATDVVNEAANMLIKDFETYLTKDIRERIIAPVILDLLSDDKYPTIMAELKAQEAAQKKENSAPLFSSNLLRQEAMSLLASKRTQVLPLPSFRKKPPTTKAQPKKRALIPMSHALNYDVDSDESEDESSRSMTPVPGLKRQHSSAISVTTEAQDEKDDVKHKKIKRTFLYQSSEDDMEVDGDETEAKAKAQESSEETKDDVDYSQLDEVYQPTFDFPRPVYETRYPLPKDEFDIEKLKDMVKDEEDYELLKEVLSEQEPNKDIKNIQYWAWKMREEVRNIPDIVQDDEELILPLDSRLESTTGSFKSDGYKKISDQDKIEYLPHRRKVDKPLKTIQNDDDDMEKSNQQSSNIHSSRVNRANNRRFAADISAQKQAIGSETDILSLNTLAKRKKPVSFARSAIHNWGLYALEPIAAKEMIIEYVGESIRQQVAEHRERSYLKTGIGSSYLFRIDENTVIDATKKGGIARFINHCCSPSCTAKIIKVDGKKRIVIYALRDIEANEELTYDYKFERETNDSERIRCLCGAPGCKGYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFG2</accession>
    <name>G3BFG2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_116743</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689899.1">
        <property type="nucleotide sequence ID" value="XM_006689836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFG2"/>
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    <dbReference type="eggNOG" id="KOG3188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="256" mass="28796" checksum="5BDC6F56A8F13C5C" modified="2011-11-16" version="1">MVPDELVLDPQLKYWVLLPISVVMVVVGLLRSNVTLLLKSDPKLEEFKKNREKQFLKRATSFKNGSSVLTRDEFLVRQEYFITQLKSSEFFANKNVSSDAPANPLTDPGSADALMEMAKGNMMNYIPQTLIMAWVNYFFAGFVIMKLPFPITDSFKSMLQQGIVTPDLNVRYVSSISWYFVNLMGLKPVYSLIMNDSSAADELVNSQQQNQQLPNLGAPGAPKVDKIFEKEAADIQILSHESIYDGIIDRVLAADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFG5</accession>
    <name>G3BFG5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Peroxisome biosynthesis protein PAS1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_96128</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the PEX1-PEX6 AAA ATPase complex involved in peroxisome biosynthesis. The complex acts as a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFG5"/>
    <dbReference type="STRING" id="590646.G3BFG5"/>
    <dbReference type="GeneID" id="18250583"/>
    <dbReference type="KEGG" id="cten:18250583"/>
    <dbReference type="eggNOG" id="KOG0735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_1_1_1"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="477"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="749"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV60686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1067" mass="118059" checksum="E238F2DF1674CD21" modified="2011-11-16" version="1">MDGHKANIVHVSSRTNLVNLPSRLGNLLANANIKVQDVIVEIVCKGKSSYTGWSGWNATSINSLEIDSILAKSLSLAETEPVVINLKVNNFETRQVNLEPVTSSDWELVELHAQTLEDKLLSQTRCVSLNQVLVVYPSSTTSANLVVTDIGTKSVNFAKLSPECEVAIAPKPRVKKRSGSVKSAKSSRTDKSGDDYMNLPSVLKRSIPLPHQLYADLPEYADTNGYEVYVNFKEVAGILKRAEYVAVSVIPGPNSKKNHTPKQEKSSPNLPGSSEKEAKETVPLEENKRVVARLVNYPKSPANHVGVSRKLAVALSVESNLGSILVLKPSIKQTQKLPSTFTIYPYITQSKKSNQVNINSSEKKEKASKLAKAIESILLSQDSSLYKSPITNFTKLPIIPNILPNGGMLKFKRNDDLNAWIKPLHGSDKKGPSIEIDEELLRAASFIEETKVEKPLSDAIGFESMIQETVEHIIIDNNSGILVHGNSGSGKTLVLKHISQQLENLHGYHCKFISCESIMNENFNSLSTSHFNRWLQECTWYKPSVLILDNLDKLIGAEVEHVDSSNSKNLAEFLVSQVQKIHCQPNCNFSILASSSSKESLNGFLFSSHLIENILHLSPPDKTTRSKLIEHYFNNDLGCKIGFDVMEMVAETEGYLPNDLKTLCDRIYHESLFNQSSAILDDEVSITMEDFEKALQGYTPLNLRGVKLQKSSINWSDIGGLKEAKNILLETLEWPTKYAPIFANCPLRLRSGILLYGYPGCGKTLLASAVAGQCGLNFISIKGPEILNKYIGASEQSVRELFERAQAAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQMLTQMDGAEGLDGVYVLAATSRPDLIDSALLRPGRLDKSVICSMPDYNDRLDILESITAKMDLENGIDLKEIALQTEGFSGADMQGLGYNAYLKAVHVKLSQDESLEQMESNTPNSQELDFFKVNSEKLKNAKMRPADRLKILQQIEELFGNSKENMDLKEKKKNSPSSVVSISHENFVESLKETKPSISVKEKLKLDMIYHEFVSGRDGNMPDGSASNDIGGRTTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFI1</accession>
    <name>G3BFI1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_96142</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFI1"/>
    <dbReference type="GeneID" id="18250585"/>
    <dbReference type="KEGG" id="cten:18250585"/>
    <dbReference type="eggNOG" id="ENOG502S4KQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051047_0_0_1"/>
    <dbReference type="OrthoDB" id="5364312at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="363" mass="38649" checksum="4320DAC1CF639E7A" modified="2011-11-16" version="1">MSQPPRRRLSIFSFGSSSNSSTTATTTKPLSANSPSTDADADADAPDHQYTRISPGTSISSASARKGPQRALTADGKLSVNTGAVNGPSPSAPVASSSPTSPGTDLNIFERSVQDNCSCGFESPSSRRPPLTRLRSKPHHGSSISLSNFKNEDYIPPALDATTSILSDSTTNLDNVDIIYSSRRNSSVIGLNMALGRPAPSRKNSVYSMSQLNSSPNIPQQPPIAIPELESANLSQSQSLNQPISPTSPPRLSSSKSSISFYSYADLINNDEFAKRPSFKQNLSQSMVPSRKNSAASGKAAVGPNGFKKFDTNLSRFLISPESSDSEDDIHSKRKSFHDTESLVSESIGECLRQNKTELSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFL0</accession>
    <name>G3BFL0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116070</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690212.1">
        <property type="nucleotide sequence ID" value="XM_006690149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFL0"/>
    <dbReference type="STRING" id="590646.G3BFL0"/>
    <dbReference type="GeneID" id="18248151"/>
    <dbReference type="KEGG" id="cten:18248151"/>
    <dbReference type="eggNOG" id="ENOG502RQCP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171960_0_0_1"/>
    <dbReference type="OrthoDB" id="4010849at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="85" mass="9943" checksum="6577EAC85A797630" modified="2011-11-16" version="1">MPRTTRQKKLLIERFKTMSDEKLESLIRTSNTVCNTYDSRINRKVNSVNVTLWNVKIKDVLEVERRKALSMKTLLDDVKSMNVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFL9</accession>
    <name>G3BFL9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116075</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689264.1">
        <property type="nucleotide sequence ID" value="XM_006689201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFL9"/>
    <dbReference type="STRING" id="590646.G3BFL9"/>
    <dbReference type="GeneID" id="18248155"/>
    <dbReference type="KEGG" id="cten:18248155"/>
    <dbReference type="eggNOG" id="KOG4313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048013_0_1_1"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="131"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="312" mass="34997" checksum="AEA627501F31FB4E" modified="2011-11-16" version="1">MVTSLLSVIEEVDGFVYGQGAGGFYSLVAHDHKSILGYVSPAIARYFASETGFVVDALTMTITIDTSYDTFDKRNQLFGDVAARWKQVPFFEADLKNGWRDEFYTVYNPTNVPYFIVERAFSVLIGVVTYGVHINGYISPVNSANGKLKMWIPRRSSTKPTYPGMLDNTVAGGLGHPYGLWETVVKECFEEAGIPAQYVENHTKSVGVVSYLYHPKGRLIDRVQPEVEYVYDMEFEDETTVVPAPQDGEAEDFRLMDIDEILERMGNGEFKPNCGLVLIDFLIRHGIVTPATEPNYLAIVSRSHRSIPFPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWD5</accession>
    <name>G3AWD5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTEDRAFT_112235</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWD5"/>
    <dbReference type="STRING" id="590646.G3AWD5"/>
    <dbReference type="GeneID" id="18246416"/>
    <dbReference type="KEGG" id="cten:18246416"/>
    <dbReference type="eggNOG" id="KOG3049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_0_2_1"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="39"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EGV66514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="259" mass="29738" checksum="3206E041F298EE86" modified="2011-11-16" version="1">MFKAITRLNTLGLRRTLATSAQEQRLKTFQIYRWNPDTPEIQPKMESYQIDLNQCGPMVLDALLKVKNEHDASLTFRRSCREGICGSCAMNIGGTNTLACLCKIDQDASKDLKIYPLPHMFVVKDLVPDLTHFYKQYKSIQPYLQRDTLPTDGRENLQSIEDRAKLDGLYECILCACCSTSCPSYWWNQQEYLGPAVLMQAYRWLIDSRDEATKIRKEMLQNSMSLYRCHTIMNCAKTCPKGLNPGRAIAEIKKQLAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWL6</accession>
    <name>G3AWL6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA/polyamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_100551</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWL6"/>
    <dbReference type="GeneID" id="18245391"/>
    <dbReference type="KEGG" id="cten:18245391"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF29">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="573" mass="62584" checksum="422051D4010BD647" modified="2011-11-16" version="1">MSDEEAKLQSVRSNIHVDDLRIQSILSNKGVTINVDHEVDSDEAMILALGYKQEFKREFNLWTVFAVSFSVLGLLPSIAACVDYQQLVVGASPVPWILAVLFIISVALSMAEVASAFPTSAGTPYAVSQLAPKRIAPVMTWLTCWSNWLCQITGTPSVNYSGASLIFALVTYNKPSFQPTTGQAYALTLGIQFSHGILASLPTRWAARINSVGTIANVLFLAIVFVMILAGNKRQEIFADDPTFGNISKFNNNSDAWGLYNQTEFPTGMAMLMSFLGVIWAMSGYDSPFHLSEECSNAAEAVPKAIVMTAVGGGLIGLLFMFAMAYTVVSLDQIAEDPLGLGQSFVTYLSQILQKKAINAAVSMTIIASYFMGESCLLAASRVTFSYSRDGMFPFFSKLGATVNPHTQTPVYAVWINFIIGQLLLLLMFANDTAIGAIFSVGGISGFVSFITPVVFKVTNAYSTFKRGPFHLGKWSRPIGFVSIAFVAVMIPVLCFPYVKGDDLTLDEMNWTVVVYFGPMLMAWVYYMVAAHKWYKGPKSNLDEGTLVYEDVDGIPDEKNYAKEDVSSTKASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWN3</accession>
    <name>G3AWN3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_117623</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWN3"/>
    <dbReference type="STRING" id="590646.G3AWN3"/>
    <dbReference type="GeneID" id="18248583"/>
    <dbReference type="KEGG" id="cten:18248583"/>
    <dbReference type="eggNOG" id="ENOG502QSNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004185_1_0_1"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057454">
        <property type="entry name" value="Bud3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021895">
        <property type="entry name" value="Bud3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12015">
        <property type="entry name" value="Bud3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25351">
        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="274"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="799" mass="92296" checksum="78FE36C520629B8A" modified="2011-11-16" version="1" fragment="single">MSVYQRLASGDEQNLEQAEGISFKHYSTDEVEDSIIINPLAGRLELSKNSEFKSKSTEEWINIFPNAAYFSSYDDSLFGHIVTAVYENPVSDKICTVSLTKFGVTVYHDLILNQDSRFYPSIENLLPIHKESKVRKALAVTFLKNYNKLVNHPGEFEIEKRWDETNAGAMASRSSLLVDKRPNEFGLKLLQMGVIQNHTLKSLVLDTVYNNTNNDSKVIESNNRLVCLLGDQLDQLFDPLLEYSPETLETSYNVPNTSNYEKPKFIDNLKIATITDELLTVQTNFTMGLVGLLQNFIIPLRVHVLESKDAQGIVKINHIFPPTIDEVTRINCVLHDSLTRAKPFGYVEVIKVFGMILPYFYKPFIRHEANLKSFKSRFNKFYGRYEKQVFADPNINKSKFSKNYIDSVITGSLLELPKIKLILMRLYEEVSSEFSKLKNFEQEEFEEPSVLDYYYKSAVDIIDAFGGDESLAIEKDHERFNSQHRIFTPTGKLLTELATNWPPELQYGWLSRKVIGIFELKNVKPNNQNNHDDEVLIIFSDTIMFLRIVDDNYYINSNGNLNLRISDVLMHSLVNEKPLPKLSSFPRMEVSHWCSITDVIVTTYKSFSFSTSSEEDFLRFFSCTGRGFKGDNKQEMNKNYEILRDSNSGNFTTGNEVIELINKAKVLHKNQPFHLFRSNKSALHLYSTAHSATNYDNENTKSQIILLLNMPQEMIPHYFEMNQHLFLILTASYTYDGRVQLIGFNRSKRPEFDAIVPEEDFQNTLLDTLKMYMNCYFNSFSLVTEQMIKSLQLDLEYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWZ3</accession>
    <name>G3AWZ3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112369</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWZ3"/>
    <dbReference type="HOGENOM" id="CLU_2960541_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="59" mass="6478" checksum="52C0BF604CBCED18" modified="2011-11-16" version="1">MRTSTTRRQPPENLVPALRGWTSRPPSIKYYFCCVAPSHCSTGAVEPEIIRGSTVTIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX20</accession>
    <name>G3AX20_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112396</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX20"/>
    <dbReference type="STRING" id="590646.G3AX20"/>
    <dbReference type="GeneID" id="18246505"/>
    <dbReference type="KEGG" id="cten:18246505"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118853_4_1_1"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00435">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="87" mass="9773" checksum="5D685FEF8C4A22F5" modified="2011-11-16" version="1">MVSALFEEKAAAVKDLPKRPNDDELLKLYGLFKQATVGDNNTSKPGFLDLKGKYKWEAWNELKGTTQDDAESQYIDLADELIGKYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX83</accession>
    <name>G3AX83_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_132971</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683974.1">
        <property type="nucleotide sequence ID" value="XM_006683911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX83"/>
    <dbReference type="GeneID" id="18249660"/>
    <dbReference type="KEGG" id="cten:18249660"/>
    <dbReference type="eggNOG" id="ENOG502QREF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008074_2_0_1"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="7">
        <location>
            <begin position="487"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="825" mass="96918" checksum="A86FA839C2DEFCB4" modified="2011-11-16" version="1">MAKSVFYVLRRGFLLLIIANTIYFTSYLLYYREEFSFPTSYASSSKSKHINVGYQDEEPTVNFATEIRRLFDKVEANVNNKFWLKNTELTNTKISINPRVFFSDSTDDDAWIHKNTLFYDMRVTLSVYLNLIKNRLVEKNSDQAIGEDVPRDDTEPASDASVPVSPTFNEVSVPFSWLDWIDLSFNDKELSTAVEQRRGCDWVQQHTSRRSDRNRLKCIDNQDLSPKELKALGYERHEQLPGFITHGFSIDPATVDVRIAQARSYIMTHLPNPFKLVFLNKHNGTYEVNVDQETPHQRIIKSDLVKKYLIDNNQMTLNGKPPQKIDLDPVVEFRKLKQQVKPTYILPSQDIYKVYATTHTFDPKQSKMLPIAKEAFHYGPETIDEQIQVFEVLEQKESLDYISRSYFDSLKRSKERNTKTEDVYFRQATLWIGHDKINKDKDRGYHYDWRFFVGTLTTYKGWTAEELTLRQEVILDRLARNWFRFAEEKGLVSWIMHGPLLSWYWDGMMFPFDNDLDIQMPSRDLARLGELYNQTLIIEDVEEGFGKYLVDVGTFIHNRDISKKENHIDARLIDVDTGLYIDITGLGTSSAEIPDNFEKDKELLQISKESSDDDVYNDRRKHFYKHGQLTPLKYSMLGGIPVFLPNDITNRLEFEYPEGMGKPEYHNWYYIPKISLWVPRDRLKNAFDDNDFLKLSDNSRDNGKVDDDRLKDLILDMDESQVIQLLEKDDEILCEFYKTKELTDIHEVEKKFLFSVEPQEDKKIKVSDKLLAGKDYDEYNALVAKNIRMTKPLRKSLYSYEYIDQPLHHQEFVEKEEALKSRNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX87</accession>
    <name>G3AX87_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112452</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX87"/>
    <dbReference type="STRING" id="590646.G3AX87"/>
    <dbReference type="GeneID" id="18246526"/>
    <dbReference type="KEGG" id="cten:18246526"/>
    <dbReference type="eggNOG" id="KOG3933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943997_0_0_1"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="152"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="309" mass="35936" checksum="0991A571D6C2E373" modified="2011-11-16" version="1">MPTTTKCVIRSIRSVRELGVRYNSTQSSENTLHLNPHVWEGLPADRIFELHNLRKDSLKQNYNPNDDERRAILSTFTSLTKKKAPLDYVYEIDNFKERYMNNTPVKLRGLPPKKSNVEVVASGQTPHDLRRRQELNRVSAFEMPLLAKLRQPYVPESDEETPIELTYYTDFSNEANSSNRRVTLSVALKHLQLNENQTRKFMILAGNKFNHNTKVLKFTIDEYPEPTQNARAAAEKFAKLLNASKDLSDDFSDIPVDTRHTKPWKPSVQFPKEWRRPQDAPVVQNNIMKKLVEHVKQKKDEQYVSKFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXF1</accession>
    <name>G3AXF1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_128794</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXF1"/>
    <dbReference type="STRING" id="590646.G3AXF1"/>
    <dbReference type="eggNOG" id="KOG0592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008400_1_0_1"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000534">
        <property type="entry name" value="Serine/threonine-protein kinase PKH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057614">
        <property type="entry name" value="PH_PKH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25347">
        <property type="entry name" value="PH_PKH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="458"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="755"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV66361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="821" mass="90945" checksum="684F4B654B677726" modified="2011-11-16" version="1">MNFKKRSARDYQFGATIGEGSYSTVYSAVDLFNKKTYAIKVLSKRHIVKEDKIKYVNIEKTTLHRLGLQHPGIVQLYYTFQDESSLFFVLDFAEYGELLSIIRKFGSLSEQVSHFYMCQIIDAVKFIHSKGVIHRDLKPENILVGFDFNLKITDFGAAKLLGNSNDTSEETIDFNGIYKDQIRDDSNGVDRKASFVGTAEYVPPELLKDNVCGFETDIWAIGCVLYQFFYGNPPFKGQTEYLTFEKIINVDYSIKPNIPLPNDVLQIIENVLLLDPSKRLTIPQIQAAGWFKNVQWNDPNFIWGRKVPRFEPYDPSSIKNGFPSSPFTTSIRTGSNRDMNKSSSQHQLHSQIQSSDFNLIPTIGAKKSYDTATKIKKLPGPGVNYSPTHQGLAIQQSPQSINQSPSVIPISQITQQAISQHVPNLTQSNSGMIPQAYQQKSVPTQVYPQNYGYMAINGSPNQKSKNSQIQQAPSSRPTVRSNNSFAANSQTAVPKYQSRSVAETQNSSSSLPYNLPQQKSAYNMNQASAAAAAISNMKISDPKAPSPPKTSSGSVSPTRGTPAKKQVNSPVLKIKFKEISPLLLPSEKILKLDVIMKSQLDSKVRKASKLSDDVIETLITSHQRSLDSTAKPVVTIITNMARVFFIDGALNVMLIDLKANQGGDYSMYDYEFESITVDSDDDVPEDGEDVYGYLIIELIREKGDLIFLKRINNDSKPIKDMVAVVDKAGKEVKLGSDYGWIDCLLIAKDMVAKQNASNGSSAKPKEKEAPPPKKTRPKSSSSAAKSTPSIPIKKDKTPEAGSKSKDTKGFAYLAAAAAHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXH7</accession>
    <name>G3AXH7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_132638</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXH7"/>
    <dbReference type="STRING" id="590646.G3AXH7"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OrthoDB" id="4021507at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="342" mass="37916" checksum="E4D9CF2A83027990" modified="2011-11-16" version="1">MVDSVLIVGCGVMGLSTALHLAKKGYQVKAIDAYPVPSPWSAACDYNKIIRTEYAELVYTKMSLEAWELWRNDPLYKDVYKECGRVLVTPPSHQGRKKFEAVGIANLQSLGGGQRIEYKKGGKALAKQFKFLKYNTMSEQSEYKWNPETGIGIAGKSLKAVYLAAKELGVEFVFGEAGRAVEIKTEGGIDTVFTADGSRYSADQIVIASGASAGSLLDLKQQQSATGLFVTHIQLTEKEYQKYKDIPVVFDSDLGYFFPPDEDTRILKIALPGSGAQNYVRSNFRDETRSLPRYKNQHPEDTMPTECMVIAKQLLATYIPELAYLSTIRPVGLPIPSIRTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXI8</accession>
    <name>G3AXI8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Skg3/CAF120-like PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_128815</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXI8"/>
    <dbReference type="eggNOG" id="ENOG502RYUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017094_0_0_1"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Skg3/CAF120-like PH-like" evidence="2">
        <location>
            <begin position="271"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="652" mass="73383" checksum="5A6ABA01FD915985" modified="2011-11-16" version="1">MHIPILTQGKDKQTWTSTTKSKNKSPVLPAINTSIPDYKRPPPVNFEVSGSTTSSSPTSISNSRSGTGYPFEEPTSPSSITRRQLSEKIRQTPSSYVRNSRVFSNDFDGTLAQSDSFNSLSNLQSSKNVNSFSNVLLANKSVPPELSPIVSLFNSHNFRTYYAGEILLFRHGEWDSVSSKLTGNELSLWYQDETFNPTYYNLFDYNITLDASNWVVKFSNDLNESFYNLILRATCQEDYVNWVTALFLSNYEKLSLNEAFTAVVLSMIGPKLSDIHTLLSKKKYPKFEWCNIRLPQINHKWLRCYVAIHPSSSKKSGRIEIYQSEKTTKKNLICYITGVTNVYNIFPENVNMIEYNSIMKLNGEVYVNSGVEHLFLSSQPSASSGAFSRAHRRATSGSSFFSASSSPPSSPKIKSSQSFINTNYIYMMPDNHPGVQAIETMIRNYIPILDAFKLYGRPKQLNSDKYDKHSLLFGLPSLPHYEYLSFDDAREIVDLHLSESQHSSWSFTEWNNAFKHMVEFKMANENYKGNGNISVLYKSLELDDSDLLSIKSLPDINFPQGATNEFSPSPVPGGSPPDSPSIDNNLASSGFNIVTTPSRVASSSFPDSPNSTGAFRFDNFENYNNIDKVASPVTQLGELDEPIKFHPYRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXQ5</accession>
    <name>G3AXQ5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endocytosis and membrane growth and polarity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112543</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXQ5"/>
    <dbReference type="STRING" id="590646.G3AXQ5"/>
    <dbReference type="GeneID" id="18246571"/>
    <dbReference type="KEGG" id="cten:18246571"/>
    <dbReference type="eggNOG" id="KOG0677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="392" mass="44165" checksum="C0199B1ACABF871F" modified="2011-11-16" version="1">MADTPIVLDQGTGFVKIGRAGTNFPDHTFPSIVGRPILRAEERSTLVPSDIEIKDIMCGSEASEVRNLLEISYPMENGIIKNWEDMEHLWDYAFYERMKIDTTGKKVLLTEPPMNPLKNRETMCEVMFEKYNFSGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLNHLTKRLDVAGRDVTRNLINLLLRRGYAFNRTADFETVRQIKEKLCYVSYDLQLDTKLAQETTTLVESYELPDGRVIKVGSERFEAPECLFQPHLVDVESPGVGETLFNAIQSADVDVRSTLFKAIVLSGGSSMYPGLPSRLEKELKQLWLTKVLNGDASRLDKFKVKIEDPPRRRHMVFIGGAVLANIMADRDHMWVNKHEWEEQGPSILTKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXU2</accession>
    <name>G3AXU2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphogluconolactonase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_112561</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in regulation of tRNA subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXU2"/>
    <dbReference type="STRING" id="590646.G3AXU2"/>
    <dbReference type="GeneID" id="18246581"/>
    <dbReference type="KEGG" id="cten:18246581"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000017">
        <property type="entry name" value="6-phosphogluconolactonase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="84"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV66137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="315" mass="35131" checksum="A5C75D7FCC5CEBCD" modified="2011-11-16" version="1">MTTTVPLVYSFPEFLGVAEAVADHVITAQNMTLYNTLDPKQIGLIKEQLLARPQLFSSLSTNSINNSSSTTSLKSKSSKKNKVKDIRFKIAISGGSLLKILKQGLIPRQKEIDWAKWDIYFADERLVPFDSPDSNYGSAKREIFDWITTDHKPNVYHIDETLIDDPQECADSYEKILIGNFAKKDSVKLPMFDLLLLGCAPDGHIASLFPNHGEQLREKLAWCLPVSSAPSGPENRITLSIPVICHAQRVTFVVEGLTKAPVMRIIMERPEKGLPSSIVNEGAAGKVTWFVDDDALKDCYDVTKKKYKFLSTPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXU6</accession>
    <name>G3AXU6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_129172</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXU6"/>
    <dbReference type="STRING" id="590646.G3AXU6"/>
    <dbReference type="eggNOG" id="KOG0285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="359"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="395" mass="43650" checksum="D523BBD83EE74B3F" modified="2011-11-16" version="1">MSIAAVQFGKNALVKLENSVVIVSREQLVPPPDTLSTALYTNNKLDYMLRNVDENLPLQSELDSSPSPEPQSQTITNNSHSTTTTNWKLLRVIAGAHTGWVRSLTVDPVTNQWFVTGGTDATIKVWDLANSSCKAIITGHIMAVRALVVSKKFPYLFSGSEDKEVKCFDLERSNSVSGCEIRNYHGHLGGIYTMALHPQLDLLFTGGRDQTVRVWDIRSRAEVMTLTGHKSDISSLIASEVDPQLISSSMDGTIRLWDIRKQTTELTLTHHSKSIRSMVEHPAESTFCSGDSSGNIKQWLFPQGELLNEFNSTDKNIINTMAVNHTNNNLFAGYDNGQFEIFDYVSGELLQSSKTIPSPGSTESSIFCSSFDLSGLRLVTGESDHSVKIWGEETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXV1</accession>
    <name>G3AXV1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_118247</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXV1"/>
    <dbReference type="STRING" id="590646.G3AXV1"/>
    <dbReference type="eggNOG" id="KOG2867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030733_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="359" mass="41254" checksum="9977CEDAA1BFA7F5" modified="2011-11-16" version="1">MKPIRRITSNDDLAKWIDSDAYKKIVEFVEALQDSVLGLTNESPCEESSTITTLLKILDQVQHIIDANPVVHEKNVSRFGKVEFRDFYNQVASESTGLVSLLTDDIDTVTEANTYFIESWGNCTRIDYGSGHELNFVCFLLCLHEKGVLLKQDYAAAILKVFTKYISIMRNLQKNYWLEPAGSHGVWGLDDYHFLTFLFGASQLATHPYMKPKSIHNEELVEMYYKQYMYFECIHFINSIKTVPSNQQRLSIRWHSPMLDDISSARSWQKIKDGMIKMYKAEVLGKLPIIQHFMFGDILKCPAGVLEYNEEEGNDQLHDHDHHHSEMNNTWGDCCGIKIPSAIAASESLRLEKKPIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYD2</accession>
    <name>G3AYD2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_92162</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684398.1">
        <property type="nucleotide sequence ID" value="XM_006684335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYD2"/>
    <dbReference type="STRING" id="590646.G3AYD2"/>
    <dbReference type="GeneID" id="18250163"/>
    <dbReference type="KEGG" id="cten:18250163"/>
    <dbReference type="HOGENOM" id="CLU_1038274_0_0_1"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV65824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29883" checksum="B610D16092A4E379" modified="2011-11-16" version="1">MDYSTISVHSLALFNINTAISNNASVGVLLGVPGSDSVCVHTAFELLASNGTIDMDFYNQRLQQHLTVLPKLEKVGIYHILDKSTPTILTEQLCQEFNSSVCLVVNLNSVSDKTFIKGYHNGKPLNTIVESDETENISLSTIIRNSQYHLSNHRSDELDQVDLNQSKNNILNSIEQMSIKVQGIVDYCNSERPGLEVSKMIEINNLIGQLSRHVSYLRSTNHKEPEFNDKLASTELALLSTKLVSLDRLKSQLNSNTANICMKSKRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYH1</accession>
    <name>G3AYH1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Membrane protein PTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_112723</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYH1"/>
    <dbReference type="GeneID" id="18246649"/>
    <dbReference type="KEGG" id="cten:18246649"/>
    <dbReference type="eggNOG" id="KOG2568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024065_1_0_1"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442444" description="Membrane protein PTM1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="190"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="64285" checksum="21BF6DA2EFA4E7E4" modified="2011-11-16" version="1">MKVLIPLLLVCQLLLGCAANRAVYDDSLNSQVCVGMYSKHDWGGSYKPQINLKLSRFGKDKYKKNKKISEQPHTEDIKMTYIIFEYQDFHSIGYHFDDGQVKYICDDTAINSLGICDQKQKGKFIINNNSTKNTILTNQLTHLGQANFSYPINETGFYCVSTFVEDETIKYNGIINFQNAFGQLSASEIPKLPAYGILTLLYAIAIGLFGFQFFKKRKANQILPLQRYLLAMLGLLTFDTLVVWSYYDLLNRSKNPSSGFVIFYMAFLSILNSLKLTFSFFLLLCIALGYGVVVVKLDKKIMLKCKILAGFHFVASLLYLFSSYYNDSVASINSTSSFDDDSSDELLALLPLIPVTVTLCIYYAMILISIKKTTANLNKQRQVIKLKLYESLFRIIFLSFFLTFAGILVASFIFLSMSTTQLIEQSWKSTFFIFEFAPSVIYFIIFMGIAWLWRPTETSYMLAVSQQLSTEENDENNAGTGFELDDLSLLSHSDDEDARVRERDSFELREDVNGALPPSYESAQAHDHHQPVERTDSNTLFELGDESDEEDRHSDDRLRGKNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYL7</accession>
    <name>G3AYL7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_101332</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYL7"/>
    <dbReference type="STRING" id="590646.G3AYL7"/>
    <dbReference type="GeneID" id="18245459"/>
    <dbReference type="KEGG" id="cten:18245459"/>
    <dbReference type="eggNOG" id="KOG2271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019986_0_0_1"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV65884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="757" mass="87296" checksum="77133163FB9FF4D1" modified="2011-11-16" version="1">MDTAVQDPLFSKGFDDIEMLDIGETSSDIESISKSSIPSAMGSEDSEPVVLKEWLNSDKPLNFHFNSREYKNSVEAKDEFSVLHSKYATSLYRVIESLGELDLRRTDDYDEPFGLIRSDRLAGTQDQNKKRESKITSAFLKLSDELNQFIAGLREIDSDYPLNYECLLSIIDCLHANVFYNSVNEKPNHLVRWVNRFDLKPEEELVEEIMVKTTTPYQHPLFWTKFIAKLITRGLSDQSANAIKNSGYEHLKEDDIELFQLIEDFIGLLESYNTMSLKKEFAQWKLSCCEFRDLIPKLKTNIKSPANIIVLEQIHDLAYILTGLPKTTANYCDTWYEIVTCLSLFQIRDDDSMYPQYFDIALEEKPPLLIDSEDILKSTERAFLNVFEGSYLHVLTKIDEIDSATAALVSRLFELKGLFSNYYTIDDDKDLNRLRTGKTISEYLLTKFAFQCLNTHPLAPVGIGILLNENIESSVSSINNNKTIIEEYLPKYQCKSNDDLEWCLTICAKLGLVTTASELYRIYGTKSLKDGYLYEALNMLVNCYSADGNLEANQKGMKEVHYIVWELIFQDTLLNNRPIKDELINNVVKHETDPTFEVHPVIKQCLSPYAVLFEFYNSISNPIAPDTTVIMAKSKTSRILHLLEFTHLPKKFYPLLLAQLIPFFIDDIYQFQIPELIVIIELIDNFEQQTSPDDFRKAQELYKHSITNFDRTQAESYDWRIKINLKQRSIPESVGDLTRLLRNEIVTQVGKVYVHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYU9</accession>
    <name>G3AYU9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_101337</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYU9"/>
    <dbReference type="STRING" id="590646.G3AYU9"/>
    <dbReference type="GeneID" id="18245460"/>
    <dbReference type="KEGG" id="cten:18245460"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015387_0_1_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV65933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="81411" checksum="718FEA625FC700D3" modified="2011-11-16" version="1">MVFFLAVFLFYTILDAIFIRFSPTTFKKQDIKMRKIIHYSNYKYGDLDGLTERHKHFKDKPLPEKCTIFFNDLMTSTSGKSWRFPTMSGRSYNKDIDKSQRFFNRERKNLLSVKSKEGLGSKISLSEKNSIKTDFDQQVKNSRVMDQQMADAISIMRVYNKCFFGGDGISYDFDKWWFNDITLRVFPYINSEMPSFDVVIENKTTTFNNGLPEFKNGEFTGNVLTPDKDQNLFDFYHKNISGKGIVLSATSSHAKDIARLIRVLRALNNSLPIQIVYRGNLSRRSKAIIIRAANIELDEGKLDPKTSELEKEVTSINSSFPKQTVIFTNIKRITDKKNFATYNNKLLSVFFSSFKEIMLLDADSVPLLEPEKFFHSSEYLDTSTFFFKDRSLRDTNDYLETNFVQRLFPMNNGSLESLFGMNILNKSSLEGNNYLRGYRHFQEAGVVLLDKKKHFNAITMLLPLGIWKEPLKTAMWGDKEFYWISLLMAGDDNFRFNENEAAAVGVASSDALKIYDYDSDEVCSTHPGHVNEFGDLLWINSGFSFCKKNRHYKDKSKYPFCKVPITELQNIYKNPFKITHALVPPSLPDYRDLNDEYNIGKEKQIEKTWKGRLKDSDEIKDFHTAGPLEPKISNPPQKGWVKSPICAGYYYCGYSIIQSYHPGKDHEFGKLYVFNDTTVSRIDTLGKLWMTHTPKSASEYFIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYW9</accession>
    <name>G3AYW9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacetylspermine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112827</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYW9"/>
    <dbReference type="STRING" id="590646.G3AYW9"/>
    <dbReference type="GeneID" id="18246693"/>
    <dbReference type="KEGG" id="cten:18246693"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_10_1_1"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="494" mass="55824" checksum="14A1B2A610E06496" modified="2011-11-16" version="1">MASMNTKVCIVGAGVAGLKTAHTLLNDPKSKFKAEDVLILEAQDRIGGRVLTDKTSSKLGYSYDIGGAWFHDCLSNTVLQESIDSGLFVVQKDGYFDDKDITVYDKDFNNQPVPVTDLKLNRVKEELEKFIEVYYHEDLSRKDMSLLEITDVYIKRYGDRLTSEQKKYLKKMIRYFELWDGFSADKISARYSLNDHEGRNLYNLKGYSFLLDELLRKIPASQIRTNTKVNTIVRNNKHNETKLRVETDKGIVYCDYLVVTVPLSILKLPSSHPYGISWEPSLPASITEALDATCFAALGKVIFEFNDVWWDKDVEQILHLPEETGSVELSAVLNQPPQKLIYPYLLVNYEALHKKDNKKTAQGGSFVLLTQAPLTQYLEENPDKAWDYFKASFKSFVQPGRTISEPINVITTKWTTNPYIRGSYSGVEVNGSYEDMVAQLSGEIEGLGLGYSTVRFAGEHATAVGSGCIHGAYTSGEREAAWILNHYNSLKWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ20</accession>
    <name>G3AZ20_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="7">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_112859</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="7"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ20"/>
    <dbReference type="STRING" id="590646.G3AZ20"/>
    <dbReference type="GeneID" id="18246708"/>
    <dbReference type="KEGG" id="cten:18246708"/>
    <dbReference type="eggNOG" id="KOG3984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_1_2_1"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="306" mass="33616" checksum="9BA46978BD77A758" modified="2011-11-16" version="1">MSSGIFDVNEYSITIEEAANTVKAKLLKYEQLRKPRVMIICGSGLGGIVNILQEPRIELRYEEIPGFKSSTVSGHAGKLVFGLIGDNKVPVMCMVGRLHFYEGYTFQETTFPIRLAKAIDIETVVVTNAAGGVNSDFKVGDLMLINDHINFPGFAGFNALRGPNLVEYGPRFLPLSDAYDFDLRRLFFKSKKKLGIDRTVHEGVYFFAAGPTYESRAEVRMIRTLGGDAVGMSTVPEVVVARHSQLKVLALSLITNVGVGEKPPSALDESPVRLDEGMANHEEVLEAANEASKDVQKIFEATINQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ75</accession>
    <name>G3AZ75_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1690-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_97091</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684601.1">
        <property type="nucleotide sequence ID" value="XM_006684538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ75"/>
    <dbReference type="STRING" id="590646.G3AZ75"/>
    <dbReference type="GeneID" id="18250654"/>
    <dbReference type="KEGG" id="cten:18250654"/>
    <dbReference type="eggNOG" id="ENOG502SDJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093897_2_0_1"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="149" mass="16742" checksum="073E83FBA510B6B6" modified="2011-11-16" version="1">MGSTTSKPEKKVFTPQAPVDFSASFLSQLENSSESDYSRAQYTEKYIQDRVAQEVKKLEAEAIKHFQQTTQGAILPEDGTPVVSVPSSNEKIQHLKQLIQKNIALTTVEVTEDIKASRKSVIECLKHNEGKSLNCWDEVTKFNQLVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZT3</accession>
    <name>G3AZT3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_102781</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZT3"/>
    <dbReference type="STRING" id="590646.G3AZT3"/>
    <dbReference type="GeneID" id="18245584"/>
    <dbReference type="KEGG" id="cten:18245584"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586621_0_0_1"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="388"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV65235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="492" mass="57164" checksum="9983DD1FA39D7023" modified="2011-11-16" version="1">MNILHTSRYLLAPSHKYQSSQKQIKFLKITPAAAREFTLYRSKPHSTITNSQMSSAWFQRLFSNHQPLPNGSNNNSSSNIPGAYPQESGESVEPSARNRFNSRNIELYLSKALEYIQMVVIKPIIFILFVVFTVFAKLINTIYFRDQFKRHRLNSGTLYDPLNKSNKFIRDIEDNLQPGQNHDMLPPFYQGSYTQALYMATHKAKFLFVYLTNPENENNSSIFNKVVINDKFKALFNDPDFIIWGGDLTNPESYQLANSLNVTKFPFLGLLALTRTTTMSPNGPVKSTPKISLLVKIQGEIGSSTNVNALIQNKFVKKIEKYEPELRLIRKELLDKFINQVFTQQQDLNYQRSLAKDRLKKEQKMQEQLEEEYFKWKLDYFNNLNLEEITDKAKIAIKIPNGERVTRLFPADSDISEIFDYVELTRKDYFNKSFDKNVDPSKLVDFRPTYKFKLMSPLPPKITLNEQLNNNILIKHLNCIYPNGLLIVEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B043</accession>
    <name>G3B043_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_133614</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B043"/>
    <dbReference type="STRING" id="590646.G3B043"/>
    <dbReference type="GeneID" id="18249726"/>
    <dbReference type="KEGG" id="cten:18249726"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_0_0_1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="333" mass="36864" checksum="F85C408ACD647FA8" modified="2011-11-16" version="1">MASTATACNPMTDPICLVTNPALSTDLSGYSSKHYRTSGNVEVLSPFHLDMSLRQRFDNPMIESKFSILYGRVECEIQAAGGTGIISSFYLQSDDLDEIDIAEIFGGNPYEFQSNFFIKGNTSTWDRGGYHAVPNPLQTFNRYAVEWTPSRISWFVNGYTYRVLDATNPYGIPSSPMQVKLSLWAGGDPSNPSGTILWAGGVSDYVGMPYTMRVRNLQVTDYSTGTFYTYGFRENKWESPSSVAGEIGGRVGGYNIEASAYLQPEMGYESDSVYQGHESDPVIQGHESDPVIQGHEADPVESGLGERLVDGLGPFSWMFTVFVFEVVFVLVWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B054</accession>
    <name>G3B054_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Golgi transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_102707</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B054"/>
    <dbReference type="STRING" id="590646.G3B054"/>
    <dbReference type="GeneID" id="18245575"/>
    <dbReference type="KEGG" id="cten:18245575"/>
    <dbReference type="eggNOG" id="KOG1743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124519_1_0_1"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="139" mass="15335" checksum="EDAF25B5A56F3BD5" modified="2011-11-16" version="1">MIWLSDRQKYGVGFTTFGVILFLLGILTFFDSGLLAFGNILFVIGIILIIGPQRTVTFFTRPTKIRGTVCFGIGILLILMKWSFLGFIIESFGILGLFGDFFGTIVQFLRSIPYIGDLLSHPLVGPTIDRVAGINTLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B076</accession>
    <name>G3B076_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_119595</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B076"/>
    <dbReference type="eggNOG" id="KOG0168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0170">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000366_1_1_1"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1210"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1569" mass="176553" checksum="D13EB0129A6B4CF0" modified="2011-11-16" version="1">MSQEEQDYEGAQTSSQNDDAYEEDEEGDEEDDYQEEYDFGEDEDEAQAVRFLGSLARASQSGNTGTQEQADDNDNDEDEGDGDEDSGTDSGYPRADLLRALGSFSNIRGGGSGTQSSFADVIQRLVGEGFVSPYGGQNNEIDTLINGLGQRDDPFILSESLNQLGEKLLMMNAITAERVIPASKLTRSIISIMNDPFLSDQLELQLVACRCLYNLMEVNLDFIHDVVNNEGIEAVCIKLNEITFIDLTEQALQTLEMISRDPISHNLIISNNGLRACMQYLDFLTIHSQRKCLLIVANVCTNISANNFDKINEVFDNISGVVKNHTDPNVIEHAWLSISRIISSFKSHPSKLETLFVTRVDLLIEVVATIVVSSNKSSVSDSNDSHKVPVSFSSCLSLVKSLIVLASTSVKISAILFRDVSIGECVVKAINKFSKNKEDLKNRGLSVISSSSFKDNISIEAIMAAPNELLSQFLTLIGYLLPINYGPQETPFLKNSHLEFEEKIEINQQRTQICRDTMPEAFWKFVNDIWSFLINSFQALMDFEVRRRILINLFRIVKFMQPDDFKKINGIEMVSALLASIVNQNKFTILKDFNNSVPASQQDTEMKTSDDEDSDESEDENVNDPNAGSKNQDNTAKLNANTLVWSSCLIVLNLIKIEPQIFIDSFEKEGLIKDISTIANHLKFISTSDPINDDYEASRPFLSMYSYKYADIEFSKDYEYKLTSMKIYSKLFHILMAIDELYVNSKEGSIAQVSSVAVEVSNEIEGLLKAQDLSRFPFSKWQESWEKFQLLLDNGSQSVSSFELVSSGIIQALNDVFKIDALGSQDSLCYISFISVFFRRNSQGNALISILVDKLQEALSRVESFEVISAGTSNQGLNLRFSSSNYYDSSQTAGMAKQIKLKLGTDPSDTSSASQLPPTMQNMVLSVHAIASFASVSTFLTQRINFFEALTGSRRNRLNNESNKTGKQTHIEFLINDEVIPNGTTIYGAIYRSLQSEPDEIVESSRIWNSVHQVSFRVVDTPVESPTNDLILYNSNKSYNELKSYDATTINILNLLKVLFEVNVYAQTLKYEPLSIEKFMSWKLTVKLNRQLEEPLIVASGTLPGWAIHVTRQYPFIFPLDTRIFFLQSTSFGYSRLIHQWQIRSNQENENINGHGSQSQRPQLGRPLRHKVRISRKLILQSALKVLNLYGTSPGVLEIEYFDEVGSGLGPTLEFYSSVSKEFSKRKLRLWRDDDPDGDEEDFVDYKTGLFPSPIDMNEIQTENGKKKLYFFRMLGKFIARTLLDSRIIDFRFNPLFLKLVQIFNEHSMNKEGFSDLKKINNLNSLRIVDPSLADSLEHLMKYVELYKNVPEHERDSILVDNCTLEDLSLSFSLPGYPSYQLIADGDNIAITSKNIESYISKVIEATLCNGIIPQTKAFMNGFSKVFPISSLIVFSPNELVNLFGNAVEDWSLETLHSSINANHGYSKDSDAVRTLIDILVHFNDIERRSFLQFLTGAPKLPVGGFKALKPEFTVVRKYPEGGSKDDDYLPSVMTCANYLKLPNYSTEEIMKRKILQAISEGAGAFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0E7</accession>
    <name>G3B0E7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113105</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0E7"/>
    <dbReference type="STRING" id="590646.G3B0E7"/>
    <dbReference type="GeneID" id="18246824"/>
    <dbReference type="KEGG" id="cten:18246824"/>
    <dbReference type="eggNOG" id="KOG3239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073511_0_1_1"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="195" mass="22487" checksum="0E6DCF7F3D236A7C" modified="2011-11-16" version="1">MEAKQVLYCDVCTFPPEYCEFGLSFNRCKEWLQANHSDLFNKLYSEEALANATSTLSIEKEAAITQDLAKKQQKEEARIERELAKKLSSKVTIKRIERNKRKHIISISGLEVFDIELKKLSKQLSSKFATGCSITKTADKKEEILVQGDLSEEAKEFIEKLLQEKGLDEVKVEQIDDKKIKKKVEQIEEKKTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0L9</accession>
    <name>G3B0L9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_119834</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685110.1">
        <property type="nucleotide sequence ID" value="XM_006685047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0L9"/>
    <dbReference type="STRING" id="590646.G3B0L9"/>
    <dbReference type="GeneID" id="18248731"/>
    <dbReference type="KEGG" id="cten:18248731"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066906_0_0_1"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="313" mass="35770" checksum="2989917DAA0D97A7" modified="2011-11-16" version="1">MTSIEKLLNGDLDLYDVLEVHHAAPDIAIKRQYRKLALKYHPDKNPAPEAVDQFQLLSTIYEILSNPTTRNDYDRIRSYKNEKHVQSQALDEHTKRFKEELLRAEQNNKTHGVDIYNKVSREFETSNQNIELLREQGLKKRRVLESEKLKPKFSPVYVSYKDLVIPQIIDLRDSGTTKVVVKWKHRPELEGQFTLDVVSDIMTVFGPVTSVKSAVSEDKYKAALLEYKDAQDAAKAVGHNYKKSATLWDGTPYRKLASLLRACTPVTSGSTDIGNIKSLETFKEEDIFTDNMAINQLLAKVITEKMSNTYSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0V2</accession>
    <name>G3B0V2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lactose regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_103981</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0V2"/>
    <dbReference type="eggNOG" id="ENOG502SST6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_197198_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000009">
        <property type="entry name" value="C6 transcription factor (Gal4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="64" mass="7536" checksum="FBDE09E1C476169D" modified="2011-11-16" version="1" fragment="single">MSDASIEQACDSCRKRKLKCSKEYPRCSKCLTHSWDCCYSPRMVRSPLTRNHLTKVENRVQKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B163</accession>
    <name>G3B163_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113647</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685973.1">
        <property type="nucleotide sequence ID" value="XM_006685910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B163"/>
    <dbReference type="STRING" id="590646.G3B163"/>
    <dbReference type="GeneID" id="18247064"/>
    <dbReference type="KEGG" id="cten:18247064"/>
    <dbReference type="eggNOG" id="ENOG502QRU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058495_1_0_1"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27381" checksum="1CE750770E678B71" modified="2011-11-16" version="1">MSTPPAIVFTDWDGTVTLQDSNDYLTENLGFGYPKRRAINDEILNGSLSFRDGFQKMLDSIDTPFPECIEYLKKNIKLDEGFRKFYDYCTSKGIPVVVISSGMKPIIYNLLKSLVGEDAAENIEIYSNEVVIKDDNSWDIVYRDDSSFGHNKALSIKEYLATHKFTNLPPLFYCGDGVSDLSAAKETNLLFAKEGKDLITYCIRENIPYTEFSNFSEILDKLTSIVEGKNLISDYVQNSDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1A0</accession>
    <name>G3B1A0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF155-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113673</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1A0"/>
    <dbReference type="GeneID" id="18247077"/>
    <dbReference type="KEGG" id="cten:18247077"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011220_3_0_1"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="360"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="589" mass="66688" checksum="DB290501BFFFC5E5" modified="2011-11-16" version="1">MSSSSSRRSGSPRSTVPLQKPTAKRSPSILVTDARTNLSNGARAPFAGQNYKRQQQLQQSQKPISSISLRKRLLTRPTRYADISVDKLLSNSSDIPSGQSRFPLSPSMPTSPNMNYSNSNHSSPPPSLRLSGSTVDRRAGKGSALPSRTSKTSQKLVLIPDESIDHTMVPSRGASADFPQISRSRAELMPKDRRAQEFSRMTAYFICEQFDLEVVSDFLSDKHEVKPRLYDEALYIPYALPLLPGSDGFRVKSNNSAKLLPNQQYMEKLINKSERADYLYEYYSGVETPEDANNYSMDPEVENDSTPFDPSEPQFFAPSDPGEEGGESESSPPPNRESLISKRDTNDESIHDFSKHHGEMFVFEYGIVVFWNFSETHEKNILADLSFAYNESVPLMINPIKEQDIETEEFHFDYDENVHRPRIYNDMITLRSADHLIKLTMSHAIAQSTKLGLFESRMINVLQSISRLPKKLALTGELGLSRGQLLKKSGKLFKLRSDVNLSSSILDTPNFFWSLEPALHPLYNAVRDYLEIDQRVQVINERCKVFLEFSDIVNDSINEKSTSRITLMFIIIIFLSLSVSIFEFFLEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1S1</accession>
    <name>G3B1S1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113283</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 9">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1S1"/>
    <dbReference type="STRING" id="590646.G3B1S1"/>
    <dbReference type="GeneID" id="18246882"/>
    <dbReference type="KEGG" id="cten:18246882"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_1"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="189"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="8">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="453" mass="49037" checksum="49AE73FB66ADCAA0" modified="2011-11-16" version="1">MVLPHEPEFQQAYNELVSALQDSTLFEEHPKYKKVIPVVSVPERLIQFRVAWENDKGEIEVNNGFRVQFNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLSMGGGKGGCDFNPKGRTDAEIRRFCVAFMRQLARYIGQDTDVPAGDIGVGGREIGFLFGAYKQMQNNWSGILTGKGLSWGGSLIRPEATGYGVVYYVEKMIEKATNGKETFKGKRVAISGSGNVAQYAALKVIELGGIVVSLSDSKGAIISKNGITPEQVEAIADAKIKFKSLEEIIGESVSAFSGSNSVEYKAGARPWVHAGAVDIALPSATQNEVSAEEAKALIAAGCKFIAEGSNMGSTAEAIDVFEESRSKNVWYAPGKAANCGGVAVSGLEMAQNSQRVSWTREEVDQKLKDIMYTCFDNCYETAKKYSKDTTELPSLLKGANIAGFLKVADAMFDQGDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1T2</accession>
    <name>G3B1T2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1687-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_113288</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1T2"/>
    <dbReference type="GeneID" id="18246884"/>
    <dbReference type="KEGG" id="cten:18246884"/>
    <dbReference type="eggNOG" id="ENOG502SVID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108996_0_0_1"/>
    <dbReference type="OrthoDB" id="4044803at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="174" mass="19311" checksum="CFE0D50AE53AD1F3" modified="2011-11-16" version="1">MSMFKTLQNSPSTISIFHNAKIPMSNKLYGILSKANYKLNEDKSKIILDLMENTLPTYDQYSLIVNNCLRDNYSKNVVASCFPFIKGSTENKVGQDRVTVNAPIGLQRLSGSGLKVFNEGEYAMIVEAFNGIEQSDSTEVSASAVFAAPLVVDWDQNMIANDEHGISNILNKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1X1</accession>
    <name>G3B1X1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1593-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_103811</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685355.1">
        <property type="nucleotide sequence ID" value="XM_006685292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1X1"/>
    <dbReference type="GeneID" id="18245657"/>
    <dbReference type="KEGG" id="cten:18245657"/>
    <dbReference type="eggNOG" id="ENOG502QXBB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029266_0_0_1"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012361705" evidence="1">
        <location>
            <begin position="16"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="3">
        <location>
            <begin position="376"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="511" mass="57158" checksum="E913E071BBA6C91F" modified="2011-11-16" version="1">MLLFSLLFLVSLAVALIPKKDFKPEVFILTDISNEPDDAESLVRLLLYSNEVDIKGLVATTSYWLNYTVHDEDIYPILEAYGKVHKNLLKHSKDYPSVSYFKSIVAKGSSAYGLLAFDQEKISEGAVNLIKSIDEAEESLFVLIWGGANTLAEALKEVSSTRSTEEVDLFASKIVAYSISDQDNAGPWIRKHFPGIKYIASVHGFSQYGHSAWVGISGDIYNFVDFGGPDTSLVTKEWVNEKVRSVGPLGKAYPMFLFNMEGDTPSTLYVLPNGLSDPHEPSFGSWGGRYTLSDISLVSGNHYGDALDYAIGKDNRTHVSAQASIWRWREAFQNDFEARMQWTVKSFEDAPHQPIIVTNGSVGYLPMVIDIVVGNEVVLDASESYDQNNNSLTFKWFHYIEPSLSQGNILEIPEIEITKLNDEGSIVSFTAPEFQQACFNVFSRPLEDCKKYHIVLEVTNNGTPSLTTYRRFILSTDKGNNTFESVEYKQAFFNGDATSQGDDDIYVHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Z6</accession>
    <name>G3B1Z6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_103245</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Z6"/>
    <dbReference type="STRING" id="590646.G3B1Z6"/>
    <dbReference type="GeneID" id="18245610"/>
    <dbReference type="KEGG" id="cten:18245610"/>
    <dbReference type="eggNOG" id="ENOG502QUJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_0_0_1"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="254" mass="27084" checksum="4E4165A4AAB40594" modified="2011-11-16" version="1">MSSIDSEIHTLHDLPLGKITVSGSSGEFIVIGKRKYYRDELVSAFGGSLVPGLSPPPAYDFANPVPLGLCAFSFTTFVLSMYNAGANGVHVSNAVVGASCFYGGAIQLLAGVWDLILGNTFGGTALCSYGGFWLSFSAINLESFGIIAAYGDDTVQLENALGFYFIGWTLFTFMLVMCTVKSTLAFFSLFFSLFVTFLLLSIGKLTGSAGCITGAGVVGVICSFIGWYNAFLGVANPQNSYVRPRVVPLPWRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2S0</accession>
    <name>G3B2S0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113524</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2S0"/>
    <dbReference type="STRING" id="590646.G3B2S0"/>
    <dbReference type="GeneID" id="18247004"/>
    <dbReference type="KEGG" id="cten:18247004"/>
    <dbReference type="eggNOG" id="KOG1522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_1_1_1"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="305" mass="33761" checksum="45E7544D38A8CEA9" modified="2011-11-16" version="1">MDIDKDTESGPAITIRSSERDHVNFVLKNVDLAVANSVRRTMMAEVPTLAIDLVEIDVNTSVLADEFIAHRLGLIPLVSDSIDELSYSRDCTCDQYCNKCSVKLELAAKCDTDSTMNIYASDLAKFQNGSTLGDPVIRDAQGKGSLICKLRKHQELRITCIAKKGIAKEHAKWSPCSAVGFEYDPWNKLKHTDYWYEESVEDEWPKSENCEWEEAPDPEAPFDYNARANNFYVDIETIGSLSPNDVFVKSLETLQLKLAGISVELNKDTVESSNAESGGLTTYGRNGGETPEINYGGSYGGSSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B312</accession>
    <name>G3B312_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114090</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">ATCC 10573</strain>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B312"/>
    <dbReference type="HOGENOM" id="CLU_3050134_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="54" mass="6135" checksum="2F9A77A542537759" modified="2011-11-16" version="1">MCDVAQFSFSFSYDLAVLFELNIGAIRCLNTSDFHSINNNFTPVVDDHTPQTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3B399</accession>
    <name>G3B399_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_104963</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B399"/>
    <dbReference type="STRING" id="590646.G3B399"/>
    <dbReference type="GeneID" id="18245767"/>
    <dbReference type="KEGG" id="cten:18245767"/>
    <dbReference type="eggNOG" id="KOG0955">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002663_1_1_1"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="220"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="274"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="740" mass="84953" checksum="F40FA09B3889EF61" modified="2011-11-16" version="1">METALNIASGLSDASKPREERDLLEIYPDIDETRLLNVFVVAHSSQSMQSYQDRLLQTNPLMGTLKEPQFRQVESSTKERPTEYHVSRIIGDYGFVDLHSKRSLYNYKPHYHRPFQTNQTETISEVIRHKKKQAEYDMDEQDSLYLEHRNRQPENTLDLSPEVFEIAMTILENLWMDLESQMKSLAGDEETMAIDLDLDGGSNINKYGHDDGIVFGTVDDQKCAVCNDSDGDNTNAIVFCDGCNIAVHQECYGVAFIPEGSWLCRKCMINQHKQFDCCFCPSKTGAFKQLDNSLWSHVVCGLWINELYFANPIYLEPIEGIDSIPKSRWKLTCYICKQKMGACVQCSNRSCFQAYHVTCAKRAQLYMSMTKGFLAAVKDKSTLKSFCDKHTPTDYILTQNEIIDGINKARVYFRDLTLLNLEKDKLDRNKQLNNKLNMFKWKTESNTPIAPRRFSQVLSAKLFEMKLDSIDDNGNLGILRGLGNKPTRTKESYLAELEQMSNDICRYWCLKRESKNGAPLIRKNNNLINTSSILYGSNTLQEVQEKLDFGKTLVADLEKVIHLSDLSLHRQYIQQQLMLADQHLMQTSFFPVSQLIRIILQELTKRYDSKKVLTNWKSRISDVSLKNISNLNDQLQIHSVAQLQKHLNELNQLVVSENKLTNNVVKVCARFYNGFAAKYQDYIEVEADLKQLPAPVHLTAEKVTLVDDLDYSDLSEVDPLDEGAEDKLVAFLGNGKQRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3C1</accession>
    <name>G3B3C1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_104714</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3C1"/>
    <dbReference type="STRING" id="590646.G3B3C1"/>
    <dbReference type="GeneID" id="18245750"/>
    <dbReference type="KEGG" id="cten:18245750"/>
    <dbReference type="eggNOG" id="ENOG502S30T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087349_0_0_1"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="7">
        <location>
            <begin position="70"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="226" mass="25204" checksum="D8037779EDA1E34E" modified="2011-11-16" version="1">MSVPHQPPEIQPHLQSEPQPLQFFNYHEYLVNDYVPVSQSVNPKHQAIVVTNFPNIYAALGSTMYKHTRIVRIPRTFDTVDNPDLVPQFSTLELGKEPAAIIKHEETHFEVAGSANGSAFGATSLTVLSNLVAPAELVDIVSTINTHLYAAFDPYGYANAIESVVDILTATLYSKVFNGRLHTKRHLQKLHAYIDHVNETHDTFHVIQPRLNGYSSLDIRVANPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3E0</accession>
    <name>G3B3E0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucraseferredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114174</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3E0"/>
    <dbReference type="STRING" id="590646.G3B3E0"/>
    <dbReference type="eggNOG" id="ENOG502QS3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34831" checksum="FE9DB5DA1DB779C2" modified="2011-11-16" version="1">MDCSSVRWSGGPVGLGIPLSGQRSAHSAFSSMLSRFKFVDRCPKPTVDTGCTFCRPALPLPIKQGPLHNTAASPWKHVLILSHGYRTIFDVPSNIYNVPGTAQKLRQLGSSRSPDFPVLISHVFFSNYREVPSKPENEVVYLYPDNLRIEFDRRHLQQFNDKYLLPANHQPAQPVYNPFQKPVPTVPHSAKVDSDSEPVDIDTPKSSLNSHDTQSVFSESPIDSSVFLVCGHNTRDERCGILAPPIVEELQKVGKETDIFGYITHVGGHAYAGNMIIYPEGIWYGRIVPEHVQGVVEAYGMGHVIRDLYRGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3L3</accession>
    <name>G3B3L3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114243</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3L3"/>
    <dbReference type="STRING" id="590646.G3B3L3"/>
    <dbReference type="GeneID" id="18247331"/>
    <dbReference type="KEGG" id="cten:18247331"/>
    <dbReference type="eggNOG" id="ENOG502QVCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093528_0_0_1"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="199" mass="22072" checksum="BAD7E529EEEFB56C" modified="2011-11-16" version="1">MNMHMMTEASSSTMDMASSTSMASSTASSTSDSMDMDTMHRYFTTAYNGYPVLFKGLKAKNGGEVFGIFLLVFFVAVFTKFLEFARSYMEQKVWVSPVDRHLYTDSESDGKNLVTESTGQIARVSVSGSIPSMLVRNAIRLILIFLPEMFGFALMLVAMSFTLVYFFAVVSGLTVGKFIFERLGSRLHMVPIPTLAHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4G1</accession>
    <name>G3B4G1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Urea active transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_121525</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686131.1">
        <property type="nucleotide sequence ID" value="XM_006686068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4G1"/>
    <dbReference type="STRING" id="590646.G3B4G1"/>
    <dbReference type="GeneID" id="18248853"/>
    <dbReference type="KEGG" id="cten:18248853"/>
    <dbReference type="eggNOG" id="KOG2348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="74632" checksum="6DC8159BAA669935" modified="2011-11-16" version="1">MTSANGQVFGISVGYGMIVGVGFAFAIIMVGITKILSKYMNEMQDSEMLMTAKRSIKSGLVASAVVSSWTIGSTLLLSCTSAYSNGVSSAYWYGAGACVQIIIFSTMALEMKKKAPSCHTYQEIVRTRYGPATHIVSIIYSIIQMVCYTTNLLINGSSVFEAITGVNRDASIVLFPIGVIIYTLLGGIKATFLTDWTHTVIIYAILLTFMFNCYATNPIVGSPGALWEMLVETSARRPIAGNMDGSLLTFNSVQGGLFGLVLFGAGWAAAVDSQLFQKAIAADHKTLISGYVLGGLCWFALPFCLSTTMGLLAAGLETHPSFPTYPELMTADQISAGLVLPFAAEALMGKSGVAMVLTMVFMAVTAAFSSETIALSAMMTHDVYKAYFDPKAKGKKLILVSHSCVIVFGIVTVALGIGLSHAGFDVSFITTASGIIVNVNVGAIIFTLFWKKVSGFAYMAGTILSTLISVAVWMGYTVSQSGYVSLSTLSTNEALAAGNTMAIGVPFLLIPLFTLIKPADFDWDIWLDIKQDDNSDFNKEHGLTNILSQDEATKAILDERNRLDKELNRQSKIGFGLTILFVLFFLILFPLPLYGSKYVFSKSFFRGWIVVMFLWGFFAAITIILLPLWDGRQSLKRLFDIVVLKKTEEKPLGDIYFVKSLEGQTIEESPDESSSVGKEKISQKVDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4H1</accession>
    <name>G3B4H1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="15">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_130213</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4H1"/>
    <dbReference type="STRING" id="590646.G3B4H1"/>
    <dbReference type="GeneID" id="18249430"/>
    <dbReference type="KEGG" id="cten:18249430"/>
    <dbReference type="eggNOG" id="KOG0342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_5_1"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="119"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="309"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV63826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="552" mass="62227" checksum="DE1549DEEA89CE52" modified="2011-11-16" version="1">MTLYDFMATFVSNQEIDSESEVEFDNEQLVDEVDNDFDEVAELLGENVQDPEAKKSKKSKQVDEELSAPRPKVEEVTKSSDDDKDVNFDFDKVGLSEPTLKAIEDMGFKTMTKVQAKTIPPLLAGRDVLGAAKTGSGKTLAFLLPAIEMLYSLKFKPRNGTGVVVISPTRELALQIFGVARELLAHHTQTFGIVIGGANRRQEAEKLQKGVNLLIATPGRLLDHLQNTEGFVFRNLRALIIDEADRILEIGFEDEMKQIIKILPKEERQTMLFSATQTTKVEDLARISLRPGPLYINVVPETEISTADGLEQGYVTCESDKRFLLLFSFLKRNVKKKIIVFLSSCNCVKYFGELLNYIDLPVLDLHGKQKQQKRTNTFFEFCNAKQGILICTDVAARGLDIPAVDWIIQFDPPDDPRDYIHRVGRTARGTDGKGKSLMFLLPSELGFLRYLKAANVPLNEYEFPTKKIANVQSQLTKLIKSNYWLHQSAKDGYRAYLQAYASHHLKTVYQIDKLDLVKVAKSFGFDIPPKVNITIGASGKSIEKKHKKQRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4X7</accession>
    <name>G3B4X7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114040</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686636.1">
        <property type="nucleotide sequence ID" value="XM_006686573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4X7"/>
    <dbReference type="STRING" id="590646.G3B4X7"/>
    <dbReference type="GeneID" id="18247227"/>
    <dbReference type="KEGG" id="cten:18247227"/>
    <dbReference type="eggNOG" id="KOG1398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012946_0_0_1"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50757" checksum="4DD437F7733E60A9" modified="2011-11-16" version="1">MSSTVSLTHRNNKNLVKALVRFVNLKVARPSLKAFIFAYLYVTLPKVINHISIAIKKKDYKSILPRILKVITKAFHPFKFPAFAASLIAIINILEPIVARFLRVSKRFHGTTETVFVATFISSFIAASVSFPQFQNHIIGYGRFLSLDLTLLVLSRAIDTTLSSTLSAVLPPFFQQFGDGLLFIASCTPIMYSWFFRPDRLPPAYRKWITSAANMDDEIVGVLKSLHDGTVKYGEKSDYLADYCERYGQDPAQADFSQDSPLPCKTVHAFKTSNCEVHALWRFVRGFKFAFKLYGSINAFMLLIPKKNIAMTLRLRRALQSSIRSSCFLGAFIALDWYGVCLTRTRLFPKLFPEVPKQTWDITWGPAVGAFLCGFSSFVESAQRRKELALFVFPRALGTLVPTEATDKNLLIERFTFSMSMAILVAYCKKNPKSVRGIFGKGLTAVMSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B546</accession>
    <name>G3B546_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_130658</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B546"/>
    <dbReference type="STRING" id="590646.G3B546"/>
    <dbReference type="GeneID" id="18249466"/>
    <dbReference type="KEGG" id="cten:18249466"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032218">
        <property type="term" value="P:riboflavin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="19"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="435" mass="47575" checksum="13FF0F4C173E1635" modified="2011-11-16" version="1">MMFSAETNPEDFPDGGRDAYLTLFGAFMGLVIDFGIANSLGAIESYVSSHQLSNVKDTSVSWVFTIHLGVMYLGGVVFGECFDKFGARKLLIASTVFMAGGLFCTAESTKLSHFILSFGITTAIGTSLGMVPLIGVLSHWFLRKRAFACSVATIGGLVGSSVFAVMLQKLYKEVGFKWAIRVMGFMCIGCMGIAIALIKERKPKKELSDAIDDILDVQPKNKSTLVTVAHFFREALDLSIVKDARFVCLNLAVFFAEIISISSLTYLTSYGLDHSISESNSYLLITLVNVCGIPSRLLSGVLADMYGRFNVMIVMSILTTVVIFGVWLPAEGHLPILFTFAVLFGVSTSATISLIPACTSQICSAERFGKVYGTLYFFLAFLTIIGMYLTSVVLGNRTLVDYRNFVLYEGGYAVAAVVFWVAARYFSVGFRWCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B566</accession>
    <name>G3B566_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_106995</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B566"/>
    <dbReference type="STRING" id="590646.G3B566"/>
    <dbReference type="GeneID" id="18245929"/>
    <dbReference type="KEGG" id="cten:18245929"/>
    <dbReference type="eggNOG" id="KOG2079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000917_0_0_1"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23413">
        <property type="entry name" value="zf_RING_Vps8_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="5">
        <location>
            <begin position="567"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="6">
        <location>
            <begin position="1119"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1270" mass="145295" checksum="5B37E278C0D5E01F" modified="2011-11-16" version="1">MTKKSFDDRSQTRISLSIKAHRSSTTDARPVPLSHSRTFQWSETPAVSVEINSPDFLFKYGQACYMDSSASLIAIGTERGYVVVFGYHQEVIHVLTPEHTTAIPESPPISSTGYIVNTSVSSLAISSDSTVVVSGHTNGLIVIWELKSGQELTPPLHQIKPITFQDRFHKNKEGHLSITITSIKIFHDNQIVSSDVSGLVFYHHGVKSLLARNYITQKLLGNNDSNGIPSPKYRIYDMDILALGNTPQITDSIGMLAVVTGSMVAVLSVFSMDNPNNLYLKTHFKMQVPKAVKLTSDSLACTGWFPCMEYEGVVSNAKLAVSWNNCLSILEVDNAILPANFVGVINDLRSKDKSIPTLPISRTARKYLKDPIISLKWMSTSSVCCFTHKEVIILYYKNQGHESLKIIGKEPLGYVPNSLDFKLNKDHISRTFNSSIKLVKMRVLLLNQKHHHSQLAIGKPISWNDKLAELLAKKYYEEALNACYFFYSSKGIGELVLFSLPESKAIRKKLVHPYLMKILWQSIPHFSNCAVYFRILATLIGESKEIDSELTEMIEMLYETVSDKAEFFDSLENYLISGTITTLSPLVLKALVSYYGECGKGEPLTEILCTINITFLDIDLTIQVCQKNKLDECLIFVYNFLIHDYDTPLLHFLSEIQNNRVDPRNESKVFNYLSYILTGRQYPIDKFIEYSEEQRAKLRTINILFRHETEFLGIQVKETSIFPILTMLLKYNSFEMLSTLNEFFEDSILNEEIESSISRQFIIDALLDIYASNDFSNTDKCHLSIFVGRNYSKYSQFIRLSDSILNQILDNLLNFNHPEIKVDCELAIQSLLTAFEPFDEKKLIEKLSYKKFYNVLISIYKGEGKYYKVLQIWLNQLDEGHADLTNVKDESFNVLTECFSNTKLGIDKVNLNTLIKDNFVKLATINTNNFVYIINNYEPSLHKQILKVNEGSVVFSYLDELFKLGCNDSELIVKYSECLSQFNSSHLYGFLKAKYQFVEGNDIHNLETILSDAKQINALTIPLTSEGKYQESLDYLLEQLESIKELEKFDESFKLYLSIIESPGFYSQQQMSTASLALNLNEQYWLKLIDCLIGLSKEMPTINEFIYKSFRKISDIKLNPNDKNETSFLKIFDTFLNNNDQTTLLNVRNILIEILISYSYESEILRLSYKIINQNIHDKLNVIKYHNLKGWSISCKHCTNCGKQLYGSHIDLSNFMVWEQRQQTVLNMMSDVKDAESTDQLRLVFFKCNHGYHYKCLRNLSSDTCVVCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5B0</accession>
    <name>G3B5B0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_123060</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5B0"/>
    <dbReference type="STRING" id="590646.G3B5B0"/>
    <dbReference type="eggNOG" id="KOG2895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018994_1_2_1"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="417"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="473" mass="54722" checksum="29A47FB56FF0BF36" modified="2011-11-16" version="1">MDSVIDDSPSGSNGEEKADFSSSRNNDDYDSETELGDYTLKRTDSSSSLSFIDLNKLLYLQDFDFGVGLDHVSDSAKRRFNEMKTKTKQRLNRLKIDSNQTRDLSKLQELLNQRLAKFDEKVHKNLESSATEKLFYALAVSCIAAGGFVLGKYPSYFHVFYTVLFCLLMPIRFYSYFKQSFQYYLADLCYYVNLLLMLFIWYKPDSKSLFVSVFSLSLGTLSFAVITWRNSLVLHSIEKTTSSFIHVMPPITLFVIVHEMPKDFVKERFPAVLKIDNWNFVNGIIITSIYYTVWQVGYHYFITIRKKKEIENGRVTSFTYLRKKNKATVLGRFVNSLPYNWMQITAFTFIQFFYQIFTMIPCPLWFKYKHFCGSFVAFVFIWSSYNGATYYIDVFGKRFEKEVKKLKQEINDLQARVDSAQASPEMKPQGSSLSSTNDGEFSKEDNAVMIDKTSGDSFTSGSHVKSFSLENSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5D7</accession>
    <name>G3B5D7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_135029</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686986.1">
        <property type="nucleotide sequence ID" value="XM_006686923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5D7"/>
    <dbReference type="GeneID" id="18249833"/>
    <dbReference type="KEGG" id="cten:18249833"/>
    <dbReference type="eggNOG" id="ENOG502QVNJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007657_1_0_1"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="72771" checksum="CCF34D85DCCA3725" modified="2011-11-16" version="1">MNEASSIPESGPSTYAIISTESSTHSDELPGEALGSTGSPPDGSDHSPENESDLDEDDIIDLGGVSNSTSQHPSLARPLSRNDANSFVGGEIIDNEPTKKIFSFQLPFGGTFSSLKSNLYSQVQHRLPNFNIFNNLNGDSEEIKEDIRLKLVRQESLNTLNEANYFKTVRTRDDVRFRAVKHSIANKYNEFIPHISSNAKPMEEYESIYSRIKGNIVILGGYRGSILRDAQTHKRVWIPLKAGFNLRKINLLLGPSLEDEVNASKYIIPDGVLKNIGPIDLCKSFIKRLSNNPNTRVKEFGYDWRLSGEFVSQQLEAFLQKIYDDTGEPTLVICHSMGGLITHRTLHKNPKLFRSIIYVGVPSECLNILGPIRTGESVLFSDRILTAEANFMMRSSFNFLPLSGKVFYNRETHEPYVLDLFNPDTWVEYNLNPLVAKSRLERKSEIFTGQSSLGTGSTLLENSLTSISSRLRSIKVRSLSPLSRSPRSETFDVAEKEASPSPTEDEDGFTVSFDSAYTYLADSLKKAHDFLLDLSYKPELEAKYPPMAIVYGNTVPSVRGSNVSSEQDIKDGNYYDFFYGHGDGVVHQKWLMPERRGFEVYDPTTKKGQIVGRFATSHGHVNLMTDLKAMGEALNAVCEAEKIWTYNETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5H6</accession>
    <name>G3B5H6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_130731</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5H6"/>
    <dbReference type="STRING" id="590646.G3B5H6"/>
    <dbReference type="eggNOG" id="KOG1735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000060">
        <property type="entry name" value="Cofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="146" mass="16387" checksum="59AD2B40B380EC11" modified="2011-11-16" version="1">MTRFHSLRVSVTDEALSAFNDLKLGKKYKFIIFALNDKKTEIIVEETSTDKDYEVFLEKLPENASKYAIYDFEYEIGGGEGKRSKIVFYSWSPDTASIKDKMVYASSKDALRRSLNGVAADIQGTDFSEVSYATVLEKVSRGAGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5L6</accession>
    <name>G3B5L6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_123263</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5L6"/>
    <dbReference type="STRING" id="590646.G3B5L6"/>
    <dbReference type="GeneID" id="18248949"/>
    <dbReference type="KEGG" id="cten:18248949"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_4_0_1"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
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            <end position="156"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="497" mass="54695" checksum="02D77F534A756A60" modified="2011-11-16" version="1">MVALERKRKHITPDANGNGVSKKHKSLTTSSSNILHSYSKLATINDIPAAKTTPLDIFVWGTGSMCELGLGPSAKNKEVKRPRLNPLLLEDHIKGKIVDFAVGGMHTLALDNNNQIWSWGGNDSGVLGRDTSKVKEQLKDMDAAESDEDDDGDLNEAESTPGLVENLPKNKRIVQLCATDNLSAVLLDTGEVYAWGCFRNNEGLLGFLRDEIKLQRVPLKMDQLKNIVQLAAGKDHILALDSKGIVYAWGNGQQFQLGRRILERHRYKALEPQQFGLYNIKYIASGDFHCFAIDHDDNVYAWGLNQFGQCALTNSHGELEDGSLITRPTLIQPLSQKEITEIVGGEHHTMALTKGGEVFSWGRYDMKEVGIPEKNLPDSVFKDQHGKVRAVPVPTKLQLSAKEDIKCKAIGTGSHHSFAVTTDGFVYSWGFGDTYGPGLGPLDEDVEKPTRIANTATKFHDILMIGAGGQFSVSGGVKIEDEDAAEDRVEKYEELDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5S6</accession>
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        <name evidence="2" type="ORF">CANTEDRAFT_114591</name>
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        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
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        <name type="synonym">Yamadazyma tenuis</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
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            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EGV63292.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="91" mass="10658" checksum="FAE06BF2ECCC1D08" modified="2011-11-16" version="1" fragment="single">MESLKDLEVKHKELERQFTQMLKEHESLKESYESSKHFKHELETEKANHEKSIDILKIQQTKLQKLGDSNKAIKEEISSVKSDKSTLASKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B681</accession>
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            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
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        <lineage>
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    </organism>
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        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
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                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="213"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="374" mass="41742" checksum="873529D383475681" modified="2011-11-16" version="1">MYIIPELNNQANPRNLKIETYNGRIKTLKDALLILEGSRLGYLPKIKRRLNGLEREFIKPNTVFAWNETECGMKRWTDGKNWSASKVLGPFLVYKELDSDKATIKKNGLIKQSFSLTTKQHEKLHLIGYYQDIEDADIPCPSTDPRLKDLKLNGNIYQEYLLYYDQYSNYEQAEQPVLMYSGYPYAVSYYQPGLAPAGVAPVSAPSSISAPSAMSAPSSISGPTPTQLPVNHSPSVSNIPYQSLMGLRTMRSSVQGSPVTVAEPHPHPSFQAHQPQQYHYPTQQGQYLPPQSPYYQYSVYPGYFYSTGNTVDASVPEAYQHSHLDRFPAIPRSKAPEVVGGIYASTVAGGKKSPTTRIGDNETLKILDKGFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6F2</accession>
    <name>G3B6F2_CANTC</name>
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        <submittedName>
            <fullName evidence="8">SPRY-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_114769</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="590646.G3B6F2"/>
    <dbReference type="eggNOG" id="KOG1477">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="81"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="504" mass="56256" checksum="B4400DF912BDA4F4" modified="2011-11-16" version="1">MAHPSSCSLIDVSYPDLSTDRASTSDSNTDLVLIFVAVFSFLSLALLVSCIALLIVFIRRRLAVSEAELIRQEENQVYLELDSDEQELYFQSKEYLAENPYFRNDLTLSQNLLISEKGIGAWEFVKDALLTNHELLILNKYELNFFKPMECSVSTNLPIPTKNDVYYFESKVYSLPNVENTKISIGMGVRPYPWFRLPGRHAHSVSYDSDGHRRHNQPFKVTTPPPFPSLIEGDVVGVGYRVRSGTIFFTRNGKKLSESKLGGHIKHFKIPHEGQLYPIIGASNLCSIHVNLGQMGFVFIEANVKKWGFAPLEGNGPAPPAYNKFNSDILLERSEIDENDLSERDSDFPPDFWRDQEEMAYDEDDANDKFSYNAYSDANSVDERITLSSLVPPNMPPSYESGSDADDEGDEAVDMPSPGSAPEELQEVEVRDLEVSVEASHPEASEVNLHSRDCKGVGAETSTQPDPQSSELPLTPTTSPLSQTPRSTSSYLTETPTSPSHVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6I0</accession>
    <name>G3B6I0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_106528</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6I0"/>
    <dbReference type="STRING" id="590646.G3B6I0"/>
    <dbReference type="eggNOG" id="ENOG502QRPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005934_0_0_1"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="799"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="904" mass="104277" checksum="3EBC1061A371EAF9" modified="2011-11-16" version="1">MSEGVRKRNRISLSCNYCKRRKVKCDRGNPCSSCVRYNVAEKCSYPGIDESNEYTNGNANSFKDLGAKPAFVVRTFKSTNGINNSPTNTTAYDLASPSSVDSGTATCFQGTQIYLAKNPYVSSDETISFYDGINSLLLNNFKRRINFGIFSWQAFIVKDRGARLVMKYLSSSKRDMLELVDGKVLAKDTPGNAQEREFKIKAIESTDSSDLIPYKKVSSSSVNSEGSKLSQKIISSTAVSLGLVMNSSIDDELKLADKVLSVLPCKKVVWLLVNKFFMDVYPFMSFFDEESFKSEITRLIGPEDYVLENVEKINVEKRLDYAYIGNLLVMLRLAYLSMFSNRQEVNEENLRSTDTSREAQDTKFLLSNPISIQIVYMAEQCLLQFDLLRKSSFVVLQFMYLLTLYHKFGPEEGEGADGGTALITNGMMIQSAYQMAINREPEAFEEGKDDEKFNNLLRKLWFFMLISDIGQVYQYGTPLAIQPEFYDTRLPFYKKGNENIKDVEMEKDVISTFAYFEGFYIKLVSILKKVINLRQPSRMKDITEMLSDFEMTIYKTFGNIEDFMISFKDDAYRYPFTKIMKCKNLINLTGFVSSMASGFMQNFELKGNMELFIYYLKKVVCVGTLSMVPFYSELICRNHINFGPTADFILNPYLLLYMHKSSQFTLSLILRVNATVHSLKRSTTHSTDMKSYDYQVRFYKYAQLSKYMEAVSKYNITSISRLANRYYYAWRVSKAHNYLLLAHTSNEIYDECDFYEVVKWFQEIPMSDIDELIDMYKGTLDKIKERKYFCPEEIKRRKTQSEPEFNRTSSFSTNLEGVEPSPITSYNDPPNQENSLPSFSSDIEAGYNDMLNNKEVDKLWAQITSDFTKDTKDTKDESKDMSFLEFFSQEKYDDNIWGLYDAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6J8</accession>
    <name>G3B6J8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_114794</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6J8"/>
    <dbReference type="STRING" id="590646.G3B6J8"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_0_0_1"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000392">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="308" mass="34584" checksum="8DB72EE141576207" modified="2011-11-16" version="1">MTSLHTTDLDGILPLLSRGKVRDIYEVDAKTLLFVATDRISAYDVIMANGVSSKGKILTKLSEFWFDFLSDTVPNHLALNDNSDDNLFKHLPAPLSEPKYRNQLAGRSLLVKKMKLIPLEVIVRGYITGSAWKEYKKSKTVHGLAIAQTDLQESEEFTTPIFTPSTKAEQGEHDENISPEKAAEIVGKELCDKVATKAIELYCVAKEYAKTQGIIIADTKFEFGLDEDDNLVLVDEVLTPDSSRFWNAANFALGKSQDSYDKQFLRDWLTTNGLAYKDGVAMPEDIVTRTKAKYVEAYEVLTRSKWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6K0</accession>
    <name>G3B6K0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_94233</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6K0"/>
    <dbReference type="STRING" id="590646.G3B6K0"/>
    <dbReference type="GeneID" id="18250374"/>
    <dbReference type="KEGG" id="cten:18250374"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="9"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="436"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="292"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV63488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="532" mass="62221" checksum="C1E859FCC0EEC5EC" modified="2011-11-16" version="1">MTSSISDEYEALEVIGKGSFGTVRKVRQKSDNHMFVRKEIDYTSMNTQERNQLISELRILRELNHPHVVKYCRHDHLMSKKSIHIYMEYCDGGDLGQVVANFKKNKETVPEEFVWQVMVQTLLALHKCHYGIDAKKVNLFASSEVEPPINSETVIIHRDIKPDNIFLLNAGKTIKLGDFGLAKMLTSQNDFAKTYVGTPYYMSPEVLMDNPYSPVCDIWSLGCVLFELCALQPPFQAKTHLSLQTKIKKGIIPDLPSCYSLQLTSMIKECITVDPESRPSCFDLLQALPVRFLRKEMELKGASAELNEYQKQLVSKNDELKKKEAYLNTIEQKIYNSKVDLQEEYTNIQKKCDMQKKQIENELIEEFEARKKLMDQEAKEVRLNYQREFKLVVEQEVQQRLKEILMTQNSDLIRKKSDPTRQNQDVSTPQAKNFLYQNNHHYSSDKLVSPNKPRGPKELMDESPTRRTPLKIRNDYDDYDSYKNHKNPQSPTRLQGNNYRKRITDELEPLTIDKRNIPEYEELYLRNKNYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Q6</accession>
    <name>G3B6Q6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_122628</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686783.1">
        <property type="nucleotide sequence ID" value="XM_006686720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Q6"/>
    <dbReference type="GeneID" id="18248913"/>
    <dbReference type="KEGG" id="cten:18248913"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_0_1"/>
    <dbReference type="OrthoDB" id="5298304at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901604">
        <property type="term" value="F:dethiobiotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000399">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000278">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF33">
        <property type="entry name" value="VITAMIN H TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="492" mass="54756" checksum="C1930D9BA4C0C6C9" modified="2011-11-16" version="1">MDSIKSEDKDLAQAHSISSPPRDVEEGHEAATRKELDRIYRKLDYRIIPALWCLYFMTSFGSNSYGLTLTMNSDQGHSIIQTLKLVGKNTSTASALYYVGYIIFDVPMNLIMTKVRPQSWLSRIVITVGLVYLCYCKLSNSGGLIAARFISGVVGAGTWPGMSYYISLWYPIERQTKRIGFYFTAAQLSASVSGLVNAGFQKMDGERGYYGWQWMYIIYGSVTIAVGISLLWWLPDRPFKEEKTASNRFVAFYNRIATPRHPLTEEEQAIHRQDLGQRYVFVAWGWKDLAMILSDLRVWPLVIMYFGVVGTGFGLAVFGSTIIKANNPSLSSINVSLLYAPIWLFDLGGILTITPFADRFKQYRYLIFCGATAIIMVGMFVTTFAHGPWNKYAGLLIAGYGLGPTVPICMSLAAEIFGARYGDVGIAVSAALVSGLGNLGSVTATYALYSGWPADVPRLYKYSNMMLVVMLGVSCVAAVVLEFIRDRVRQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6T3</accession>
    <name>G3B6T3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114325</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6T3"/>
    <dbReference type="HOGENOM" id="CLU_1175263_0_0_1"/>
    <dbReference type="OrthoDB" id="4082794at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="236" mass="26992" checksum="28FEAE279F9B6B9F" modified="2011-11-16" version="1">MFTDKENIPVAETQKSISTNISSQLSNIELSTKQTTVDLTELVNRSRNNNDNLNKLLNSLVHNNNITKPDLVQIFDEYKINPRDIVDPIVSELQAVHLDSKSTRLLEAILDRLSVEKDTYTWQDEMRAMLSQLTDDHDTTNAISSLESKYNVLEAKYKALESKHTQLCSLYSTKFVALQQLQKQYETLLHQTKQLEPQLDMVTNIETLHNLKLSSISVPKIKKRIVSTPPTLDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6U2</accession>
    <name>G3B6U2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Longevity-assurance protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114330</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6U2"/>
    <dbReference type="STRING" id="590646.G3B6U2"/>
    <dbReference type="GeneID" id="18247375"/>
    <dbReference type="KEGG" id="cten:18247375"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028277_2_0_1"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="141"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="390" mass="45236" checksum="B3E4708C89A45E89" modified="2011-11-16" version="1">MTERTLLKQTDTDTTDTLKPSTPKPNPSSKSSDGTRYENSFVAFIERNSFPFSRTVLFLLYSLHIFSKNSTVHTWTSKLVTLSNQTGIDANGYPVYDICNDDAFVVLHGVLLFMFIRSFLMIYVFAPFASYTFRMDKRAKVRFAEQSWSCFYASFSTIYGMYLYYNSEYWGHLENLFAGWPHDKMSTSFKAYYLMQIAFWLSQIIVLNIEEKRKDHYQMFGHHIITSLLCIGSYQNYYMRIGNLILILMDFCDVCLTGAKVLKYAGFSTLCDIMFVCFLLSWVILRHGVYNYLFYYAMANAESLMTLHRCVPGVVEEKCWSRFVLYTCFVLLAILQLLCIAWLYSISKVAYRVVSGTGAEDVRSDSDDSDDELEDEQQSNEQQLAENKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B736</accession>
    <name>G3B736_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_106582</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686881.1">
        <property type="nucleotide sequence ID" value="XM_006686818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B736"/>
    <dbReference type="STRING" id="590646.G3B736"/>
    <dbReference type="GeneID" id="18245899"/>
    <dbReference type="KEGG" id="cten:18245899"/>
    <dbReference type="eggNOG" id="KOG3907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028824_3_1_1"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27905" checksum="F7A8D2D30CDEF16D" modified="2011-11-16" version="1">MISAIAALLICTFMGAISYGLGILPLHLDVNNHIKPVSLFSGGLLIGAALCLAIPESIENYTKNAKNDSKWIGISVMLGFVSMILVDQNYQKPERQEISINDYDVSPPPSSIFKSILHTSLTLALLIHSAIDGISLGSAFHRDSITFVFSLVVIIHKLPTCFSLSCLLLQKGVNAEMVKIHILAFALTTPLFAILTWIALLAVNPSDTVIGILLLFSSGTFIYISTHILGEFKEMTFTEMGILIVGILVPGFLSFMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>G3B758</accession>
    <name>G3B758_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114419</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B758"/>
    <dbReference type="STRING" id="590646.G3B758"/>
    <dbReference type="eggNOG" id="ENOG502QQMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065604_0_0_1"/>
    <dbReference type="OrthoDB" id="5582146at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="361" mass="40950" checksum="AF5E902811ED61AD" modified="2011-11-16" version="1">MNNLLVAVSLALANNRRCVVHTCDLDAAVTALKTVVSSADLEAVEVDLKSLLDQNDSLLSSLTTQVSGKRWLRDVLIWRSVEQCTAEQQRQLVGILDQLDGYDTNAHRICPRDTIQIQGQDVFLPVFHTVIMVVEVSGFENGISAAGSMLPTWYKRLKEKFWFSHFYTQDGQDEPRSLQMVDYSKELLKVRSRIPCVHLSHEIMDYIHSLMVFIRNHRLQSLAPLQTRLSTDTIDHVSLLARSIVAWSRRTDSGSNTSLYVTPEVCQVAMRKIGYWLVDWQIPGGLFDLSARVPTGKDTEEQLENNRKLVVNMLAGAWYGSEWPYVKEYIQQHEARFDPTSNTGYSNSMIEDSISAVQPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7C4</accession>
    <name>G3B7C4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Formate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_95131</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688410.1">
        <property type="nucleotide sequence ID" value="XM_006688347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7C4"/>
    <dbReference type="STRING" id="590646.G3B7C4"/>
    <dbReference type="GeneID" id="18250480"/>
    <dbReference type="KEGG" id="cten:18250480"/>
    <dbReference type="eggNOG" id="ENOG502QUGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020549_1_0_1"/>
    <dbReference type="OrthoDB" id="4829at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01005">
        <property type="entry name" value="FORMATE_NITRITE_TP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61411" checksum="A3F99F5421D5CDA8" modified="2011-11-16" version="1">MADNSMYITTHEAALALVATAMKKARLRFDTLVVNSLIGGMLFSVGGMFHVIIYSKVSSTSSEIPLYADLMIAACYPLGLFYVVIMGAELFNSNILFYSVGVMRGAVSVVDLIISWLVSWWLNLAANIFVCYVICYFSTIFATEEVISGSRELLDYKASFMFHQTLIKAMAGNFYVALAVYLQIMAKPLHVKFILIFLPIFSFVGLGFTHSVADMFVLTMGLVNGSSHSVGEIAWKVFLPGALGNMIGGTFFGIVIPWYSHIYSVEQDQRLLNLPQYELRDEQPEINSDSRVVRERRRVSSAIIDEKPKTHSTDISGSTSVEQFSPPQGLYDDTSIVSDSSHARSLSRVATGASLHSRHTSLRSRSHSFRSPKNVFPVYGMGEPLERERTIASGKYEDAPEPMTDDGDVESERSAEFVGTRIKRILSRPPHTDLEHQRSHTKSVSSRRTKPTLRQYSISSQRSYRSNSSAYRNRMYNAGIPPSAMVNSDFVAGVASGTPSPSYTPVLAPATRVRRASTEPGSMGISGSGSIPKRTDSNVSPNHSSEDITDLSRLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7X7</accession>
    <name>G3B7X7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">POPLD-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_124668</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7X7"/>
    <dbReference type="STRING" id="590646.G3B7X7"/>
    <dbReference type="GeneID" id="18249043"/>
    <dbReference type="KEGG" id="cten:18249043"/>
    <dbReference type="eggNOG" id="KOG3322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007205_0_1_1"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="5">
        <location>
            <begin position="457"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="82031" checksum="24FA21AC51D5E9BF" modified="2011-11-16" version="1">MDKRKKIFNTRTIRTELADPAYKDGLLSVPEFLGARSFEIRSFEISQLKTRASAANRVFQSLPRILRRRTASHNVKRVPKRLRNRAIREMQDTNITKKKPTSKQIYQLRMSKKLLKLASRVKLLKSVPIDSQTHMKSRIKQLNEQLADLRSSKSHNKPVLNNIMGSYDNTGVNELAVRPKGNLKYSKRQREHVWLTTHVWHAKRFHLVKRWGYQIPLSPTQKCFKSTNRAAKSNTIIFDTSYFDSLIMDYDETVISNLIKPSISVLKGHKSYNGWLYIDSKPVGICLMYCSPAAGKTLLRIHPSIYEELFNHIRETYGVNLQDCRYSLGSIELVGPTSLRSLNKIFHITKEIPEFKNLCNYNDDFQPGTTMSFNIKDPRLWSKPVNPPVSQEMSYNDLIIKLSSGLIDQESILQLFDPEGRNHSYLNQHTTKELNKHPDPAGINESIPILLTKTSSSWCLIVPWFWVLPIWLKLNQISHIHLGGMNQLKQLDFENGRLSYLEDYPYLPESWIDNELQIKLSQQKYNKLPLSKRQREKFEKGLLSFGNDWEFLTKLIFITKKVGKLEDKFEFGQFDENMVKQIRSVDDLVDHVDSSRNFKLCIELFDPNNSFHQSFTRGDYKVDLSKLPKLPIRIVRFELPNGTLNDHARIYVENASHIQNLVGFVTTGGYNLNRGKMAGIGYISAHIPEGTNLVIRNIGTSKEHKIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7Z6</accession>
    <name>G3B7Z6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115156</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688787.1">
        <property type="nucleotide sequence ID" value="XM_006688724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7Z6"/>
    <dbReference type="GeneID" id="18247745"/>
    <dbReference type="KEGG" id="cten:18247745"/>
    <dbReference type="eggNOG" id="ENOG502T2NA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865983_0_0_1"/>
    <dbReference type="OrthoDB" id="3993572at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="272" mass="31947" checksum="43443F09ADF70EA6" modified="2011-11-16" version="1">MNDSNKQQELLNTLLQLAEKEKKNGNTSITQDKLNNLSSYIINHNKQNQFNKFNTYYPVPEPEPLPLDKTPTQNPINKYSPLFKKFTLPAKKTTTTVRKFNKKSTFKKTENLIIGILETLANILDNLHLFSKFPMFPQKLLGLLKQTNKLWILILIFLIRKTVSQLLNLIKKENKIKVELKIVKESSNKMFDNTILKKYEKVLKDLKFDKTMLILELFGNFLDLGFNFIESYGVPVPDWFMNILNFSSMFMTIYRMNKDDEYIDDDVTEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B804</accession>
    <name>G3B804_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_98870</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B804"/>
    <dbReference type="STRING" id="590646.G3B804"/>
    <dbReference type="eggNOG" id="KOG2543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028223_2_1_1"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC5 lid" evidence="5">
        <location>
            <begin position="227"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="4">
        <location>
            <begin position="308"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="54800" checksum="9D35508D5CA97F24" modified="2011-11-16" version="1">MSTQKILELKKRIQFRDQEFDLLNAFLSPNHEECAPVVFVHGYNSVGKTLSVFSFLDTIGVKKTVIQCDEVVNNRLLLQKCLKLIRTDSGQDLRKSNTFYDRGGYSAKLTGCDSFSSFAFNLQMFIDQTGYNDPHFLVLDRIDSFIDEPINIVNSFIRMRDCTNIKNIIVIFISRTEIPNPAVTSAIPQVYFKPYTDQQLVSILQKNQFCFFGDEELDNSVVGTQFWHSYVQVIVDSYHEYCGTSISMLIDFIRTVKTRQISPSEFMKVYREQRTIFQDDSILNAAVIDYRTDELEQAGTKVSLSDFTYLAKFILIASYLASHIDPRLDMYYFTSAKYSKFVYSSKKGNEITKRDIDVKLLQPNFFDLERLYGILTVIYRNESASFNKDENSPEFADKTEVYISERSHEIAKFSLVSNIDLPSQMASLLSRGLIVRQFSRDILQPKTRWKSNLSWEEISSISKDIGFPIHNYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B825</accession>
    <name>G3B825_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_126111</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B825"/>
    <dbReference type="STRING" id="590646.G3B825"/>
    <dbReference type="GeneID" id="18249148"/>
    <dbReference type="KEGG" id="cten:18249148"/>
    <dbReference type="eggNOG" id="KOG0797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006974_0_1_1"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="810" mass="92063" checksum="488E87A676BC2C3A" modified="2011-11-16" version="1">MTEEEDKKRKKVKKPSAEVLQRRKEGRIKAAAALASNLKKTGIMRVEESNGFPLSSIKPVPLINQKNYFTDYLKKDEQIVFIRRWRAEKLLKQKLKKLNSKKPDDGQSEDGPRNFDDFNLNDIEEEMKRKNVDPIDADDDDEDDDDENGDVDVDADGEAGETDGVVTEKARIGSDVVVIHPGSSNFRIGKAVDAVPECIPAVVAIRHSTSPSDYLPEAPQRDYLATDIPEEDKRVWFGEEFEACKSEMTKDFKARMRFYKRRVLPNSREVAANFNKRKEPEVIPEHNDPHKTEWIDVGQHEGQRQFVGEDALKLPICDKFGEWKLRSPIVNGRFNESSDYGSREELLGDISSIINLGLSKLDITNVKDFKCMLIIPDLYDKVIVEQFVQTLLQTVGFGRVAYLQESVAASFGAGTSSACIIDVGSQTTTVACVDEGLVINDSRIRLNFGGDNITETLTKFLLQSFFPCREINLNYQYDWQLAQTLKHDFVTFQDADIAVQIYNFYRRKPFEHTLKYEFKVFDEVMLAPLGLFYPNIFTIQQNPKSRLFPKAVDQYSLKSNNPSSKSQENIVNGVSFTNLTDEDLLERLHNSYKAVKGNNPFAKAKLTSTDINETAASFPLERAIIESITNACLATDITKVKKFYSNLLFVGGGLSKIPGFDTLMTDRINIWRPKFLSTSNVDELLEYVEQQEKKSQQLRQKLVREILASHGPDEPDPADESALTPEELASVDEQCQLTLDLDYVDSLVDKGQLLPVTVLPPPREFDPEILTWKGGSIYGRLKVVNEMWISQNEWDLLGSRCLYYKSLYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B845</accession>
    <name>G3B845_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_115809</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689046.1">
        <property type="nucleotide sequence ID" value="XM_006688983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B845"/>
    <dbReference type="STRING" id="590646.G3B845"/>
    <dbReference type="GeneID" id="18248030"/>
    <dbReference type="KEGG" id="cten:18248030"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_3_0_1"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="183" mass="19512" checksum="99F160E270F04AE2" modified="2011-11-16" version="1">MFSSISRQASKGQLTRLFSSSSPRLVKVGDKIPQIPLALESPGNQFVLANEIKSGKALIVGVPGAFSPGCTASHIPGYLENFSKFSGKGFNKVFFVAVNDAFVVDAWSKSFANVPEGVTFLADPKGEFVDALDLKFDASAFFGNERSKRFALAVENGSVIGAFVEPENTPVDVSEATKVLSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8A2</accession>
    <name>G3B8A2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_115180</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687895.1">
        <property type="nucleotide sequence ID" value="XM_006687832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8A2"/>
    <dbReference type="STRING" id="590646.G3B8A2"/>
    <dbReference type="GeneID" id="18247758"/>
    <dbReference type="KEGG" id="cten:18247758"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="11"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV61725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="359" mass="39656" checksum="D9F1555CF905321E" modified="2011-11-16" version="1">MVYPQTFEGYAVTDSATWNKVEKIEFTPKAFGPKDIDIKISACGVCGSDVHNVRGGWHKPHLPVVPGHEIIGTVVRIGDDATTNLKVGQRVGVGAQVWSCLKCETCLEENETYCPDWVDTYNDFYPDGSKAWGGYASHIRVHEHFVFPIPDVLDSNDVAPMLCAGITVYSPLVRNNAGPGKKVGIIGIGGLGHFAIMFAKALGAEVFTFSRTNSKKEDALKLGSDHYIATYEDKDWSTKYARKLDLIVSCGNSSKNFDLDGYLKCLRVHGKLVSVGLPEEPFTVSPGTFIKNGSLLGSSHLGSRQEMLDMLKLAAEKGIKSWHEDLKVDEEGISEALTRCYENDVRYRFVLTDYEKSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8A8</accession>
    <name>G3B8A8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_108092</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8A8"/>
    <dbReference type="STRING" id="590646.G3B8A8"/>
    <dbReference type="GeneID" id="18246002"/>
    <dbReference type="KEGG" id="cten:18246002"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000224">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="64"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="560" mass="62917" checksum="4F1287807CD91C5B" modified="2011-11-16" version="1">MEINDRNNADFIPGTFNIYTQSGLKHEGADSVADNRLKMDGDIILVPQPSDSPNDPLNYSTKRKLLNFFILAFITGFTAATSNDAGATQDDLNEEYGITYDSMNTGAGVLFIAIGTNTLLTAPASALYGRKVSYFFCIFVGMMGAVWLSRSKDTADTIWNQLFVGASESCAEAHVQQSLSDLYFQHQLGSVLTVYILATSVGTYLGPLIAGFITQYCGFRWVGYVAIIISFFVLLAILFLMDNTYFDRNKYNKKLLDEHRKVDNMDTKNDKEHEADSRDQGQINVVETYQESFVSENGAKETKNSYWYDKKLVRRAPNVIGTGFKQYMKLLFMMFRVFLFPGVIFSGFIWGLQDALLTFYLTVEDDQYYDPPYSYSDTGVALMNIPCLIGAIIGCFFAGVLSDKFSLWMARRNNGIQEAESRLYFLFVPGVLSPVGLILFAVGTDQHWPWFPTYFGLVLIGFGFGAAGDVALGYLMDAYPDMVIEMMCGVSVINNYIGMIFTFACSPWLDAMGNTHTFIILAVIEFVASMFAAVMIYYGKTIRIKTTRWYLDYCRLRDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Q0</accession>
    <name>G3B8Q0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_95294</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688577.1">
        <property type="nucleotide sequence ID" value="XM_006688514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Q0"/>
    <dbReference type="STRING" id="590646.G3B8Q0"/>
    <dbReference type="GeneID" id="18250494"/>
    <dbReference type="KEGG" id="cten:18250494"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV62407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="271" mass="28701" checksum="6883A47142BC5024" modified="2011-11-16" version="1">MSFGPKAAQRLANKVVLITGASSGIGEATAREFASAANGNISLILAARREDKLTTLKADLIQQYPEIKVLSRVLDVSKTSSILSFVKGLPEDFADVSVLVNNAGKALGRSEVGQLKAEDVSEMLDTNVLGLITLTNALLPHFRAKNRGDIVNVGSIAGREAYPGGSIYCASKAAIRAFTGALRKETINSRIRVLEVDPGAVLTEFSVVRNYGDKAAADKVYEDTEPLGPEDIAEAIVFGVTRNLKVVIAETLIFPTHQAGAGVLHRGSLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8S3</accession>
    <name>G3B8S3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_115880</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689082.1">
        <property type="nucleotide sequence ID" value="XM_006689019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8S3"/>
    <dbReference type="STRING" id="590646.G3B8S3"/>
    <dbReference type="GeneID" id="18248066"/>
    <dbReference type="KEGG" id="cten:18248066"/>
    <dbReference type="eggNOG" id="KOG2818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV62912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="368" mass="41515" checksum="5B42D72F5118E407" modified="2011-11-16" version="1">MSIGNTDETVATDAIVPDSITATALPANGDGLVSRKPTARVQVVKPLEVSTDTAQKHPPNSLRNTGIVSVFFWLVDELRRFIGGGSSSAANDSKSTGSTSTINLFITYFNHAILLIIFFIISIYKNYLYVRRRIHLKFLNLTYFPNKSPHIIRDDVNKLSRIPKRVSCIVNFKDEEEENGGIDGLINDISELTAWSVSAGIQELSIYEYNGVINDYYLELNRYINKNLKNYFGTEYVPNISIKSPHSSKVLVNKPEKPIDLYVNLLSKVDGKPTIVELTKTISELAINRELSVKDITIDLINDELVELVGSEPDLMIIFNPNLDLQDYPPWHIRLTELYWEPDNKDITYAVFIRALQNYAKAKVNVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Y2</accession>
    <name>G3B8Y2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_124978</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Y2"/>
    <dbReference type="STRING" id="590646.G3B8Y2"/>
    <dbReference type="GeneID" id="18249065"/>
    <dbReference type="KEGG" id="cten:18249065"/>
    <dbReference type="eggNOG" id="KOG1077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="716"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="46"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="968" mass="109326" checksum="F3D6991A7E95A5F6" modified="2011-11-16" version="1">MKGLTQFIIDIRNSQDFEQEKKRINLEINNIRTKFSSNLSTYQRKKYICKLMYIYLSGYDDLVDLGVKESLSLISAKTIQEKSLGYLTLSIIFTSHSDTAHTGFKGTNTYFEELLGSVYSQLSHDLKIDNEIFNALALQFIANNFNLPGYQLPETSVVISKFLELANQVYSFAISPMSALLLKKKSLVCLKMLIQLYPNLLVVNDNWIPRLFSLVDYNNDLSIILNGLPVAELVVGMKPTQVKNLVASLTNNLEELVINANCDESYFYYGIPAPWVTIRLLQLLETCFLMDSSLVINLNPKDLKTLKQVISTSINQSTKSINALSNKNIQSSILFQSVGLAIFLNASSESILGAINALLHLLKSTDTNTRYLALDVLIKLISRSSDEKLTQSYNGLIFDRMGVAEHLLNDKDIGIKRKTLDLFYIITNDSNYQVIINKLLDYFPMLDYQLKSELSIKIAILAEKFAKDSTWYVNIMIRLLSIPGSSANSEFLNNEIWERIIQIIVNNDELHVKTCKLLMGKLIRSDQLSENLVKMSAFLIGEYGSLIKNEFPPQIQFQALYKIYVTAGLVSRSMILSTFIKFCNCYPDEDFIPNIIDLFEIEKDSIDIEIQSRANEYLNMFTMNSKGLLSNIIRPLPPFETKKNHLLSRIGTLNHIVGTDKSSFMVNAAKIQKKTTNGNGNGNGSLIDLGGPEADFENPFQEEKLVLSPNWYNGYHRMLHFDAGIFYESQLARITYKVDRIDDFKLLYKLQVINNSYKSTSNQLTSFKILELKSNANTVDPSYIMNLTKTPDQIILDKSSIEIEVKVRGVVDVEQSPVLSISFSCGGSFNQLNLKFPVNVLKTLTPTTLLVEEFKTRWLQINQLLPNNKGEFTIRPNTAYKYTASNIVRLVQRLRFSIVFSSSEDDPNKVLVLAAGILHTQTNNYGVLLSIKSVGTEGKHFEITAKCTGEGVAEIIAVAMGEIFQGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B947</accession>
    <name>G3B947_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_126474</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B947"/>
    <dbReference type="STRING" id="590646.G3B947"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024583_0_0_1"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="223"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="503"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="701" mass="80050" checksum="5D83F5BC7B7E553F" modified="2011-11-16" version="1">MSLKDDLKDNDSEDSLISQFETTLTIRSTANDYEDDVSMAHSTFYNHSGYMRDQTIPIYEEDEDDDDEVIHPAEIIQFKGKRTNRLKTTSASRSSSNSRSSKSPSPPPIPELIWEETQKYEKILKPSSLIDTSLSKFTNTFSDFLKSNPQIERDSPKFRKESDRTLVVLSPYSAEHAFGRKWVTKSYLATIFERPQRLLASCIGIAAALTMYPFFYKIVNSTKRGSIFSSHVLKIHGKNWPRKLYELCLESHEKLAEGNLEVPEDWNTGDIYLIPKTINAIEGVIGAIETGIDSLFKQNYNLSFIVIRPPGHHSHACLPSGFCLLNNVQIGIEYAFENYDVSHVAILDIDLHHGDGSQDICWERAGFTGDYGKDEDEDLELGFEPRDEYGKRFARYPKVGYFSLHDVKSYPTELGYATKENIKNASTCIMDHDLNIWNVHLQEWEDEDEFYKHYKTKYVSILNRVNQFLNQAKKQHELEFQQYLINKKNGSLNSNSKDKPPMAFKPMIVISAGFDASEYENPQMQRHGINVPTSFYSKFTNDAVKLSKIHNSKLISFLEGGYSDGALTTGIFSHLIGLTNSVNAHMEGDKVDSNLWNSTWGSDFVMKELTKGCKKNWMPYKQPKTDVTIWANEAIKLGRSMMPNAVLPNNYIYQYKEEGAGDIPNRMVKDLIDADTRINEDGGPRHTRSYLKKLALAQQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B956</accession>
    <name>G3B956_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_99467</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B956"/>
    <dbReference type="STRING" id="590646.G3B956"/>
    <dbReference type="GeneID" id="18250861"/>
    <dbReference type="KEGG" id="cten:18250861"/>
    <dbReference type="eggNOG" id="KOG4208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025741_0_1_1"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="92"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="232" mass="26523" checksum="D56427914342A3BD" modified="2011-11-16" version="1">MAQKAGSKYQVKPVKRTEIEELSANKDEIEVASSSSSESDINAESDVELSEDSESDSEDEQDQIKGLEDNRKHVIIKPARIIDTSKSKGKKGVIYLGRIPDGFYEAEMEKYFKQFGEITRVKLSRNKKTGKSKHYGFIEFTSVQVAKVASEAMNNYLLYGHLIKCYVVDNPSDLMFSQSKFKIIPWRSVSKHRNDKPKSQQHWDKLSKKFESNQQKRKSGLQQKGIDLGYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9A6</accession>
    <name>G3B9A6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bul1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_125085</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9A6"/>
    <dbReference type="GeneID" id="18249078"/>
    <dbReference type="KEGG" id="cten:18249078"/>
    <dbReference type="eggNOG" id="ENOG502QSAC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022027_0_0_1"/>
    <dbReference type="OrthoDB" id="4094610at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022794">
        <property type="entry name" value="Bul1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007519">
        <property type="entry name" value="Bul1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04426">
        <property type="entry name" value="Bul1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04425">
        <property type="entry name" value="Bul1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bul1 N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 N-terminal" evidence="2">
        <location>
            <begin position="134"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="3">
        <location>
            <begin position="571"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="3">
        <location>
            <begin position="739"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV61851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="88470" checksum="4B9C7CA4C30226D4" modified="2011-11-16" version="1">MMFSQKERGRNGISIRSSSLASDRPDRSQGTNRFNLSLPQDQMNAGFPGPELRPLVSPSYDEVPIWNILPSYQLFESTFSKSINPTQEDRRESPPTYYNVTTPESSGTDSSPEAGYFHVDSSVRVPQGDVLPTRWEDTILANTHKMKRLADLGLKTPSKLKVEIYFTTGRGKPSILSQPIDVSGYEYQQGDEIHGYVLVQNTSSEPLDFDMFSVVFEGRVTVMGDVSDSKRPVVFHKFLNMFDYNASWTPAELDDRNTDLEHYTDSLDGTLLRFPYEKKFFPKVVYKKFFDFTLPERLLDCACESHDLERHCQVAPSIGLAREQFLQSIRRMRQRNPKNRQTGSADFSLTPIRSGFGSLAPVLSNSSQNKKMSSLGEAFGDRVKDLSFPDTAISYGVEVRVVGRASQFQPSIDPVTSDEFVMMEESSAFVRVIPHESHVDEVDKQDLQLEAKLVYQNLLSRVNQKIQLGKDLTSEGKGDTARELLRKLSISKRRQLYTTQNHTRAAEYDDDDTSEHKISMPLKRKQTITSNPKIVGFLELSSPRQNHVVKYIPAFKYHERQSVGSTLTTKLRIPVDIFFKALEARKPPEVKSVSTELVVFTSRSSKYPVPVVITPGMVYNNTYGPDDFEHNIGSKFKKYLDEITELINKVGHEAMGVDSQMIMDIKALADLSCKYHFLKVDDVHVKSEGGLSHWDVDKAGTDSMKGQYKKSLDIFIDLNSVLSKEIAISSEDLQKGCFTLVPGFQTCIMGRLYFLKITVKFQNHESISLKLPLDIVSRQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA05</accession>
    <name>G3BA05_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_98619</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA05"/>
    <dbReference type="GeneID" id="18250789"/>
    <dbReference type="KEGG" id="cten:18250789"/>
    <dbReference type="eggNOG" id="ENOG502R6HI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4084239at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="668" mass="77294" checksum="C55E51F6C2FFF1CA" modified="2011-11-16" version="1">MFDRLPTHLIEEIFQYVNQFDLLNLSLVCSQFYGPAIGRLYKRITVVLNGEFPVRYKNKSNLFIQENGIKYMDSALIFKPQNLMLLLDTLKRNKTLVSKVNFFVFDKCNSLKVDNIPVGFVQNQIMDFFGANSSDIHFLHITFIEFFHCIDKLTEFLRNNNVRNKVFKLFVTKLNELYIPCVPQNLTNLFLMLDESELADIDEIDLSSAPYNLFYSLFTLACSTNNQLGLEVLSKIKLLDPELKLNLKGLTLFHCHKESIMGDEEGNNSDPVSFNSNILSRPELMNFFDGIDKRLRFDILDSKINVASLTTLHLKIDCNEHRYNSCNCFSQFFMDFTKYSEEHDGLPNLTNFEVELFPNLEWLRPHQILENNLTPLSTFVTSLSSLSRLTIDLSTPGFKMFDNSMGMTSFILNRLNERLMEAFFLRFFTTGSTRTRLNLKTLHLPDFLTSFIYYKPDFYKSLLHTCKCWGCQLLLNKLKDLFHPLIEDDDDDDDDEEDDEARSEEMDIQSTYYILIGFILGKLQADREVCVPIKQNAFNYRNYPIYKGAPHTLHSHFHTSNSGSKCKCGISNGVADINEDPNGLEALSIDNLVTTYVVHQLKPIVEFLPSFFVQLDSLMIHGIYYEKQGSGMVPIFDEQEYPCEFLAEKDLEIRSGSHPDLPFGKFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA23</accession>
    <name>G3BA23_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_94878</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA23"/>
    <dbReference type="STRING" id="590646.G3BA23"/>
    <dbReference type="GeneID" id="18250448"/>
    <dbReference type="KEGG" id="cten:18250448"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_2_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="324" mass="37067" checksum="5C27D9C87E95632E" modified="2011-11-16" version="1">MTSIVPKISLRDFDNRREEIKQQLYEAATNVGFFVLKDQESPSIQDIEKAFAHSADFFAKPDDVKNKRPFVKLENCGYEFQAQVRPSTGTPDLKESLQLQYHKKDEYWPDTDDMGEDWATFIQQFMQKNQELSMKVLSCLAESLGFESDFFTTAHQIEKTTAQSTLRLLHYPDITGQHIAPNSWRAGAHTDFDVMTVLYQRTGDLGLEVCPGREAHTSFASGDTWYPVEAQTGEIVINIGDMLMSWSDDTLKSNFHRVRTPMVGENQKSRYSIAWFNQANKDVVIQGPNKKYEALTAKEYITNAMKRNFAKLSEKQEQLAVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BA76</accession>
    <name>G3BA76_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_107375</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BA76"/>
    <dbReference type="STRING" id="590646.G3BA76"/>
    <dbReference type="eggNOG" id="KOG4122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_1_2_1"/>
    <dbReference type="OrthoDB" id="5430106at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052143">
        <property type="entry name" value="Mitoribosomal_bL36m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL36M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="92" mass="10445" checksum="8B75180EB69BCB1D" modified="2011-11-16" version="1">MFRVNSLVKSLVVSSRATSIRSNLLFTGFRSSIPVSTSVFSTPSVFGSLNPIRTFKVRTSVKKFCKDCYMVRRKGRVYVYCKSNGKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAE0</accession>
    <name>G3BAE0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_115497</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAE0"/>
    <dbReference type="HOGENOM" id="CLU_2996354_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="57" mass="6272" checksum="59AB9306269B8529" modified="2011-11-16" version="1">MGANSHQCPASLAPFPPPPRHAVVLDDPHFRPLFPIAHSTVPSPPRYIQNNTMAVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAI7</accession>
    <name>G3BAI7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_94317</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687581.1">
        <property type="nucleotide sequence ID" value="XM_006687518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAI7"/>
    <dbReference type="GeneID" id="18250383"/>
    <dbReference type="KEGG" id="cten:18250383"/>
    <dbReference type="eggNOG" id="ENOG502SG1V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1012537_0_0_1"/>
    <dbReference type="OrthoDB" id="4062597at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="257" mass="30114" checksum="23FA262D2AC61553" modified="2011-11-16" version="1">MSEFELLILPKNYLVTRSHWTPYYKFVNKSYDKPRFQYECVSGKRISSPTSFLSDLDLEANLDALLFILLGPKDVCGKLQRDFDLESQSLQDAYACDIPKEYFEKLRFNASKVKIKEINDDYDLQDDLYRVLASSGYLVKETFDNQLTLELTAFTSFMRSLGSLTFEFVVENYLQNLKFLEYTNNPQISSQKYDKVLIEAYVIREHGLVDFYIKKCKFQPTTYPDKLFKPELTTTSKRIIAKAEFSLAIFHREVDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAK5</accession>
    <name>G3BAK5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 20">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 20">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTEDRAFT_114903</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20 21">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 20"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAK5"/>
    <dbReference type="STRING" id="590646.G3BAK5"/>
    <dbReference type="GeneID" id="18247628"/>
    <dbReference type="KEGG" id="cten:18247628"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067602_0_0_1"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000021">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 20" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00070582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EGV61428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="219" mass="24876" checksum="B449E77742191EC3" modified="2011-11-16" version="1">MSSNSKSSTTVSIKDVFFFIPNLIGYFRVLTAIASFVTMKNHPYYTFILYGISGFLDAFDGYAARKYNQGTRYGAVLDMVTDRCATSSLICYLCVIYPQYCFIWQLLVSLDLASHYMHMYAMMSTGSASHKNVGKEQSRILSLYYTNRKVLFVVCLVNELFYVALYLHSFQFFWLGTVLAWLSVPIWAFKQFANLVQLKAAAIILASMDAAEKSKPKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAM7</accession>
    <name>G3BAM7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114916</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAM7"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2190126_0_0_1"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="109" mass="12217" checksum="A5E5CEAD5383EABF" modified="2011-11-16" version="1" fragment="single">METVKYFVENTDIDVNVFGGELQATPLHWACRNGLVNMVNYLVNHGADPTLRDSQAYNALHLSVHSSNIMLVIYILYKCCGSNGSIYVDETDSSNRTSLHWACYQGDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAY7</accession>
    <name>G3BAY7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114953</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAY7"/>
    <dbReference type="STRING" id="590646.G3BAY7"/>
    <dbReference type="GeneID" id="18247650"/>
    <dbReference type="KEGG" id="cten:18247650"/>
    <dbReference type="eggNOG" id="KOG0179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_1_0_1"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="242" mass="27262" checksum="FC82FD561AAB181E" modified="2011-11-16" version="1">MNTTIASEYSAETHATPIEHRFNPYSDNGGTVLGIAGKDFAVLAGDTRHVEGYSINSRYEPKIFNVGDDIVMTANGFAADGKALINSFKTQLKWYKFDHNDKRFSIQSAARYIRHLLYGKRFFPYYVSTLIAGLDDEGKGCVYSFDPVGSYEREQCRAGGSASSLIMPFLDNQVNFKNQYEPDSDGKVKKPLRYLELDEVLELVKDAFSSATERHIQVGDGLEIHIVTKEGVRVEYFPLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAZ7</accession>
    <name>G3BAZ7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_114961</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Cytosolic inhibitor of vacuolar proteinase B (yscB), probably regulating protease B activity during limited proteolysis. PBI2 is a component of the LMA1 complex, which is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the heterodimeric LMA1 complex together with the thioredoxin II/TRX2. LMA1 binds to the ATPase SEC18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688713.1">
        <property type="nucleotide sequence ID" value="XM_006688650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAZ7"/>
    <dbReference type="STRING" id="590646.G3BAZ7"/>
    <dbReference type="GeneID" id="90981605"/>
    <dbReference type="KEGG" id="cten:90981605"/>
    <dbReference type="eggNOG" id="ENOG502SBW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156026_3_1_1"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="6">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="73" mass="8198" checksum="249E948591DBFD37" modified="2011-11-16" version="1">MSFKDYIITLKEQASEADVASVKSKVSELGGTIKNEFSLIKGFTASLPVIHFDSIKKHEHVFNVEEDQEVKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB04</accession>
    <name>G3BB04_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_94387</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687665.1">
        <property type="nucleotide sequence ID" value="XM_006687602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB04"/>
    <dbReference type="GeneID" id="18250390"/>
    <dbReference type="KEGG" id="cten:18250390"/>
    <dbReference type="eggNOG" id="ENOG502RZF6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069182_0_0_1"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="312" mass="34751" checksum="DC6831BC7360D43A" modified="2011-11-16" version="1">MSRARVLKRFVTTSTDISRAVATETLLTGTGNGPFIELPEFEPLGNPTNLLSVKMPQSSNLSIRHGSLIAMNGDLAGVSSVSRKLSDSFKFQVLQSESAVSLIVGGKMKPNRMNNYTLLHISDKSETWTVFNDSSVVAWTGYGLEIEPTHVLSRWNSVKTIGKGHVLVSDGNKMLEIDIPEHESVFVTPNSLVASTVEPVFRTIQTFNVLPKMPQLSLRWKTPRFVANAYARAVERLGAQNVVAEVSRSATRFKYHINNVVLFVRLYVVNRVFGKPIWAQISGPSKLLVSTNEQVRGERVFTKQEIEDIYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBL6</accession>
    <name>G3BBL6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_135512</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBL6"/>
    <dbReference type="eggNOG" id="ENOG502RPTY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789880_0_0_1"/>
    <dbReference type="OrthoDB" id="4074633at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV61567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="351" mass="40553" checksum="D729D3756AB3A2BD" modified="2011-11-16" version="1">MNSQTMSQRLAIPHLLPYTAIEPLSDQIKLSSKIFKSTSMKAITEAYNTTLIEAILVPEIEHQVNYHHKVKPLEEIVNEKGPFRVRIRYTNAGTISIPFLKTQTPRLQPMKEVGIAVKNSVRDAEIRKNWESTTSPSSNDKKTTDGAFEIGWYRVYGPKATMFSKEHHAELHSQEALWEFLLDQELLKGVDENGESVTVEEVRSDVSQIKKSYTDSWLQTLNEVSGYFASRCDQHYQKYGGRYINALFDEKIKWQNRMDETFEKKIRSYEQLINSLEVDRVTMHSDLVSPKSNGSSSDKQLVTNDKRVKKRRVGMGLHERRGLGKRLGDYMEENGVPCYKIGMKFDKKFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC05</accession>
    <name>G3BC05_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_110572</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC05"/>
    <dbReference type="STRING" id="590646.G3BC05"/>
    <dbReference type="GeneID" id="18246205"/>
    <dbReference type="KEGG" id="cten:18246205"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_4_0_1"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="269" mass="30264" checksum="E4D3E6AB827F9710" modified="2011-11-16" version="1">MLLKPRLILNHTRSMHVESIPMRWGSGDNYAYLLMDSDSKDAWLIDPAEPDEVLRYFKSHNLDFHLKAIVNTHHHYDHSSGNKHFHKVYPTLPVIAGKDSPLVSHTPAHKEVIELGTNLSITALHTPCHTQDSICYYAEDATTNQRVVFTGDTLFTSGCGRFFEGVGAEMNKALNTVLASLPHDTIVFPGHEYTKSNVVFSSKILKSLAMQKLSQFCQTNEFTTGKFTIGDELEFNPFMRLHDPAVQEATGETDGDKVTTKLREMKNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC93</accession>
    <name>G3BC93_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_116192</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573</strain>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC93"/>
    <dbReference type="STRING" id="590646.G3BC93"/>
    <dbReference type="GeneID" id="18248199"/>
    <dbReference type="KEGG" id="cten:18248199"/>
    <dbReference type="eggNOG" id="KOG1783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_7_4_1"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000037">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV61030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="83" mass="8701" checksum="681546E9E625BC19" modified="2011-11-16" version="1">MSEVSSNSSIKTDPSTFLSGIIGSKVSVKLNNGVSYVGNLQSIDGFMNIVMDTTAEFIGGAASGTKYGDVFIRGNNVLYISKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCW7</accession>
    <name>G3BCW7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_99719</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="15">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex. Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore. DASH complex oligomerization strengthens microtubule attachments. Within the complex, DAM1 and DUO1 may form the microtubule connections. On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings. Interacts with the outer kinetochore component NDC80; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCW7"/>
    <dbReference type="STRING" id="590646.G3BCW7"/>
    <dbReference type="GeneID" id="18250877"/>
    <dbReference type="KEGG" id="cten:18250877"/>
    <dbReference type="eggNOG" id="ENOG502S08R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092107_0_0_1"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="180"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV60226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="249" mass="28031" checksum="005EBCDF05BC6EA2" modified="2011-11-16" version="1">MSSSSKPATPARHRHSHRSSGVFALLPQSPRIHYPIDPEHLPLDSSVITDSFERLHDSVQDLEMYMKHLQRLHEAISQGFNESFSSFLYGLSITMWCIDFPSTPSKDLEEKLEESKRLDDSITDLKSQLRRARQQNEVLKLKLHNKAKVNASILRSKPAINRRLIQDSSKSKIPQPFSRLVVPSRNSGSVSKPPPVRSAIPIATRNTRGPNLNQPPRYLDGLFAGSSTSASSVRRARKPAPISNRPPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCX0</accession>
    <name>G3BCX0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_132061</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCX0"/>
    <dbReference type="STRING" id="590646.G3BCX0"/>
    <dbReference type="GeneID" id="90981847"/>
    <dbReference type="KEGG" id="cten:90981847"/>
    <dbReference type="eggNOG" id="KOG1563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047737_4_0_1"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="335" mass="38765" checksum="0EF2055B927791E2" modified="2011-11-16" version="1">MNKLRFTRPTVFVRTVKTPTIDWKPIVTSKTNVTEAEIQSKHPVFRRVLLGLMIAMPVISFGLGCWQVKRLDWKTNLISQCEKQLAKPPMASLPPDLDPDAVKDFEYRRFYVKGKFDYSQEMFLGPRIRNGMAGYLVVTPFQRSDGGKPILVERGWISKEKVIPSTRENNYLSHLALPRGEIEIMAFFRNMPEKSSMQFDHQAGTRQFFMPDVAAMSLQAGTLPVYAQMVYDMADHPEWGSGRLSRWWTWLQPRQQPQDDFEMQFQEFEFVKNGVPIGRVPKVTFTNNHLQYLATWFGVSIASSGLLAYQMYKSKKFAGADKVLEAKKKDMRQNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD54</accession>
    <name>G3BD54_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrimidine 5-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116969</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD54"/>
    <dbReference type="STRING" id="590646.G3BD54"/>
    <dbReference type="GeneID" id="18248526"/>
    <dbReference type="KEGG" id="cten:18248526"/>
    <dbReference type="eggNOG" id="KOG3109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059493_0_1_1"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="31583" checksum="E74CF96C2A0401FA" modified="2011-11-16" version="1">MTSPVTYTNPELVQDTRLGCTVQLPLGFGPVPPSRKKIFYFDIDNCLYQRSTKIHDLMQLKIHDYFKTHLELDDKDAHALHMNYYQTYGLALEGLVRNHKVDALKYNEQVDDSLDLKSVLSYNQELRNMLIRIKKTHQFDCFWLLTNAYKNHALRVVSFLGIGDLFDGLTYCDYSESPIVCKPMKLYFDKCLSITGVDNNDLDLVYFVDDSEINVKAALKLGWGRVFHFIEIDADYERILQSDDFGEYYSQDNSDGRKITILRNILELESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDQ8</accession>
    <name>G3BDQ8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_116409</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDQ8"/>
    <dbReference type="STRING" id="590646.G3BDQ8"/>
    <dbReference type="GeneID" id="90981824"/>
    <dbReference type="KEGG" id="cten:90981824"/>
    <dbReference type="eggNOG" id="KOG1483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_4_3_1"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="11"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="414" mass="45482" checksum="CA88541DD4C86A0E" modified="2011-11-16" version="1">MNWKEVRIISLLVLDTVFFLLEAIVGYTVHSLALVADSFHMLNDIISLFIALWAVKVKNTKPADGKYTYGWQRAEILGALINAVFLLALCFTIVIEAIQRLISPPEISNPVLVLVVGCLGLASNFLGLALFHEHGHSHGGSSTPSGHTHSHGGASNVDEEAGHSISESEPLLSRNQSTGDIRQYMPENFIQRFEDGHHHNSEATSSASSTTDKKQKQKKKSMNMEAVFLHVLGDALGNIGVILSALIIWKTSWAGRFYSDPIISLFLTVIIFSSALPLCKKSSKILLQATPTHLDSALIIREITKMIPVKSVHDFHVWNLNEDILIASLHLQLDETLDSPDFEKAKFVDIVREVREILHKFDIHNVTIQPEFTGDGDIPSQASIDSGLYGDSAGGACSVDKATGCFNKNCLKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDV6</accession>
    <name>G3BDV6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_116443</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDV6"/>
    <dbReference type="STRING" id="590646.G3BDV6"/>
    <dbReference type="GeneID" id="18248308"/>
    <dbReference type="KEGG" id="cten:18248308"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001406">
        <property type="term" value="F:glycerophosphodiester transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="54"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="528" mass="58213" checksum="87E037AF01843F23" modified="2011-11-16" version="1">MATRDLPKSFKQLSTGWIQHLDNEITFNRKTPSQIKEEEDPNYVRKVKMKNLWPAFCAGAGLFSEGYVNNSISTVSTILSRIYGTAYSESNAISNVSSIAFVGIVLGQLGFGYVSDHIHRKGGMLVANVMLIFFTLLTAVGTWGAHGSPGGLFAALTTFRFFLGIAIGAEYPTSSVIASEFANQLPSGHRNRYFVWFTDFMIDFGFVVSAFVPLVLLWIFSTRHLTAVWRLTLGLGVFPPLALFFMRLKVADSDAFKKMNIKRVKKVPFLLIAKFYWFRLFIVSFIWFLYNFSVYSFGTYSSYIFAQIIPTDADGNADLYKTFGWNVVFNLFYIPGSFLGGLMADYFGPRLTLAIGVGLQAVVGFIMAGCYDSLAKHIAAFIVVFGIFSALGEVGPGDNIGLLASKTSATAIRGEYYGIAAAWGKIGAFVGTWVFPVIISHTDGVKTPIFISSGFCVISCILALFFVPPVGQDAINKEDDDFLNYLVDNGFDVSQLGESVEIDEQAQKESEGDSDVQTVNEILDTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE18</accession>
    <name>G3BE18_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall assembly and cell proliferation coordinating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_116473</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE18"/>
    <dbReference type="STRING" id="590646.G3BE18"/>
    <dbReference type="GeneID" id="18248326"/>
    <dbReference type="KEGG" id="cten:18248326"/>
    <dbReference type="eggNOG" id="ENOG502QTAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027501_1_0_1"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="138"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="511" mass="56693" checksum="817A241CA1D948C0" modified="2011-11-16" version="1">MGIFDNVKAFVHSITTDDHYASYDSPYRDSVINNNSNLVGGNNLNSSQTRLNELNNGSSASLVPGAEGGSEAGKQAPFVTYRPGLRSSNTNLNGSDLQLQSLNRNGQPPLPSIDSLWERLAKWLDEEYPELYDSLNDGVTTADLNEFEKDLGCGALPVELRQLYKKCDGQFSGGKPTGLFMGLVFLDLESIIEEHTIWTKVAEKLERQQYYIQKQQKQQLKVDDSPLMADSTDVGSSVEGIKAKLVGLDINNNFIANQRSIPPNSIQPYYSHKGWVPICRDYFGNQIAVDLAPGATGSWGQVIVFGRDFDTKLVIASNLQEFLFIFVSDLENGNYKIDQSEIDASFGYLEASRNDDDFIGDEDEGEGELLFYDKDNEFGKSGNPLTYLDVLKRRTLKKHGITNVNHFVTSFVPQPTKRQERPTESHSAGASNTDLSNTPSPIINLESTSKVNLPKETIIDDKSNITEEANEETKPEEAEVTETKTPEVNETEETKDEPTADASEELKTVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEN2</accession>
    <name>G3BEN2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_131838</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEN2"/>
    <dbReference type="STRING" id="590646.G3BEN2"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_1_1_1"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="13">
        <location>
            <begin position="12"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="11">
        <location>
            <begin position="194"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="12">
        <location>
            <begin position="679"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV59933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="820" mass="94037" checksum="83E96F03F7DC9BB7" modified="2011-11-16" version="1">MLQLTQQTLKNWSFRQAGDEDWKPSRKGAETTEIHPDLIENGLIPDPFLDDNEKLVQWVGLKDWEYKVSFTPEASVSKLKVHELVFEGLDTFADVFLNGRKIISTDNMFVHYKADVGKYIKFGEENELRIYFYSAIVKGRELEKKFGWHGCSNGETSRTHVRKAQYHYGWDWGPLLMTCGPYRPIKFVSYDLSIDEVFVDVGITDELNASIDVKTTICGFAADAALQINVLSPSGETVASEKGQELKIGENSTKLYLESPQLWFPHTHGTPALYDFELTIVVDGHVIHSVTKKVGLRSVELIQEPFADQPGASFYFRVNGVPVYSNGSNWIPAHSFQTCLTPKDYTEWLELMVNGNQNMVRIWGGGYFEQDIFYQECDRLGLLVWHDMMFACAQYPGYKEFEESVEKEVICQLKRLRNYCSIALYCGNNEDYQSADRFKLTDETFFGKKRYEKSFPKLVSQYSPAVPYHPGSPWGGSSYKDETAGDIHQWNVWHGTQEKYQDWDKLGGRFVSEFGMEGAPALKTYEECITDPKYRYPQSYMIDHHNKSDVFERRLASYVTENVKMTGSDLDSWIYATQLMQAECLAYAYRCWRREWRGDGKRYSAGALVWQINDCWPCASWAIADFKKRPKLAYYSIKKESAPIVVGFYRTGIKKENGASNSNAKYSIPFNYNTTQYFLDIWGVNGTTSDIKAVFKVDLYHVTTGEKLKSLEDQKVILKANQSTEIFKQYELDTEIPIVAHGTFYDEEGSVLAAGADWPQPLKYLFFPDRKIEKVVKDGSITLSTNKPVKGVEIITENDIYLDDNGFDIFPVTGCEIYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEZ0</accession>
    <name>G3BEZ0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115996</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690182.1">
        <property type="nucleotide sequence ID" value="XM_006690119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEZ0"/>
    <dbReference type="STRING" id="590646.G3BEZ0"/>
    <dbReference type="GeneID" id="18248116"/>
    <dbReference type="KEGG" id="cten:18248116"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_2_0_1"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="150"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="352" mass="40338" checksum="631183C1A8F60FA1" modified="2011-11-16" version="1">MDGFATRVRTFDAFPKVDSEHTVRSLRGALSTIATYFFALVILWVEVGGFLGGYVDHQFVVDDQIRTNLSINIDMTVTMPCELIHTNVVDITDDRFLAAELLNFEGVHFFAPPQFFRINSQNKEYETPDLDHVMRENIRAEFYISGQKINQVAGAPACHIFGTIPVNHVQGEFHITAKGVGYQDSLHTPWERMNFSHVIQEFSFGTFYPMIDNPLDMSGKITHESLQSYKYYSNVVPTLYERLGIVVDTNQYSISEQHLVIRKDSNGRIYSPPGIFFKYEFEPIKLTIVEKRLPFIQFVARLGTILGGLLILAGYVFRMYERLLRLLFGRKYTERDTEKKDGGLLAAEKKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEZ6</accession>
    <name>G3BEZ6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_116001</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEZ6"/>
    <dbReference type="STRING" id="590646.G3BEZ6"/>
    <dbReference type="GeneID" id="18248117"/>
    <dbReference type="KEGG" id="cten:18248117"/>
    <dbReference type="eggNOG" id="KOG2790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034866_0_2_1"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="14"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV59973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="393" mass="43046" checksum="D37D16DB585D3286" modified="2011-11-16" version="1">MSEQNPLQRGKAHYFGAGPALLPTDVLQQAALDLISYNGENVGIGEISHRSKPAIQVIDDTKANLTKLLDIPDTHEVFFMQGGGTSGFSSIAYNLMANYATKHNGKLGKAAYAVTGSWSEKSLEEAVRLGFDAEVVVNTKNIKFSDIPSYSEWKPLNKDNTAYLYICDNETVNGNEFKDTPPQEYLQGVELVADMSSNIVSKRIDVSKYGLIMAGAQKNIGLAGLTIYIIKKSLLEQASDNQLKEWGIPLSPIAFHYPTVVKNNSAYNTIPIFTCQILKLVTAKLLKNGGISAIQAINEKKAEVLYGALTKYPSVYSLAVKNSKVRSNMNVVFTLNNPDLDSVFLKDAGEKNLQALKGHRSVGGMRASIYNAVQLESVELLAKFVIEFAEKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF57</accession>
    <name>G3BF57_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_111263</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BF57"/>
    <dbReference type="GeneID" id="18246261"/>
    <dbReference type="KEGG" id="cten:18246261"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_5_3_1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1320"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1370"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1403"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1431"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1476"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1256"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="770"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1573"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="806"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="854"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="877"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV60643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1659" mass="186586" checksum="98559B02132BF2B5" modified="2011-11-16" version="1">MSDNNVSSTPYTDTDGMGGPSPDSSSNPNHLSIPSSTPQARRKRGLSLRTQLFNKALASNLINPSVFELNAKQNDSIEMSSMSQTENTSVHFNVPIQRSGTPQITIEESNDDRKPGFSPYGYSSTSLNGQSSHLSSDSIASEASSFEFISRQRKVHHRHQLFSSLTKLKNKILGKTELPPTKNGRVIPVSFSKGINSVFGLDLYDETTKDLIDERSGEPYCSNVITSSKYTRYSFLPKQLRAQFSKIANCYFLCVAIMQMIPSWSTTGKFTTIIPLMIFISISIAREGFDDWKRHKHDKEENNRTCVRIKEDDSLSSFDAQSISTETLSVDMNGSEVSFQSVQDTETPVFSAHDIQSLQRYNLKEVRSRWKEIRVGDVIKVCEDEWIPADIVLLSVLNDTEADIAYIETMDLDGETNLKSKFSPPDVSNVMSKASGLKNFNELMTVEDPNTDLYNFEGLVNLEDKSIPLGPDNIVYRGSILRNTNSVLGLVIFTGEETKIRMNNIKNPRTKAPKLQRNINYIVIFMVFVVASLSGFSLMAQKFKYGDIKDKAWYLYKKDAGTAPTLMSFIIMYNTLIPLSLYVTMEIIKLGQLLLLQCDIDMYHAESNTPADAKTATILEELGQVSYIFSDKTGTLTDNLMFFRKFSVNGMSWLHDVDVASRESDSANFTFVEPEALDTDHINEQVLQGSRTNSFEVSSRKSTTSYVRESIELSPTQSTPAWKSTANPNKLQDSESSLGLLKYIQSHPNTLFSRKTKFFLLSVALCSTCSPKRKQAPPDGSLNSLENTSDFEDDQDISYQSSSPDEKALVEAARDLGFVVCNKKNNSVTLKTYPNGFKEAPKFEQYQVLDVIEFSSTRKRMSIIVKFPDNRICVICKGADNVIIERLKHSEMAKTKAKEISLNASERKMMEADVVLQDRFSQEAEVRRSTGSIKSIRKSLHLSGPSSPEIADTIKSVDSYLMTKDESEVNDVAQRARESLHLQQAQRYSLDSTNGIPQTEYSFVVDDRILVNDEYLIEKTLEHVEEFSTEGLRTLLYSFKWMDQKDYEQFSEKYQIAKSALSDRAKKVEEVGESIEHSFDLIGASAIEDKLQDGVSEAIEKLRRAGIKMWMLTGDKRETAINIGYSCRLIKDYSTVSILNIDHGKDEVRKRILSTVKKVNGGGIAHCVVVVDGATLATIQNDEALMAIYIDLCVVADSAICCRASPSQKAAMVSAIRNLDKRSVTLAIGDGANDIAMIQSADIGVGITGKEGLQAARASDYAIAQFRFLLKLLLVNGRYNYVRTSKFVLCTFYKELIFYLTQAMYQRYTLFSGSSVYESWSLSMFNTLFTSLPVLVIGIFDKDLQPATLLAVPELYSKGRLYKGFNLKIFVTWMILAASQSVGISFLSWYIWGFNALKDNSTLPLGTLLFASLVIIINAKCEFTEMQNKSWVSFAAFIISVGGYGVWNVVIMMLYRSSSHSIFYADYGLLEFGQDVSWWASLLVISVIPIYLDVIIKVFKFIIKPNDDEIFRAIEKDIHMRRSFEQKAYNELKTGWTSPKDSSIWYKRYIKVINGLSSRLGSNIHLKDKYMDETSEQRKRAGTSTSPDELPPGSDGEVVYSVGAEYHASNNNSEYEVLPSGKRVKRNRSKSILDRITRTEHEEDIDAIISDRLDGFNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF93</accession>
    <name>G3BF93_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SEP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_116026</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF93"/>
    <dbReference type="STRING" id="590646.G3BF93"/>
    <dbReference type="eggNOG" id="KOG2086">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029402_4_1_1"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="170"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="281"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="361" mass="39794" checksum="AAD2FDC683E71592" modified="2011-11-16" version="1">MNQNEKDQLIERFVTVTNSSPYLAEQYLARNENDLMNAIEDYFASNTKSSGSTPTSTTKHKSGVRTFKDLNEGDDEDDKTDTNFFTGGEKSALQVEDPNKDKKSGRSLIDDIFQKAREQMSQPDDRPSTGEPETAAAPTFVGTGYKLGDGEAPSQTIPDVNAHASRKPTLVKREITFWKQGFTVGEGHLRRYDDPANAGLLEELNRGRVPLALLDVEFGQDVDVSVIRKTDEDYKPPKRKLGGFGGSGHRLGSPVPGEPIVTPDPRPVEVKTTPVVAPEPEAQGDTPVQIRFANGKKVNKRFNSSDSISVVYEFVQSHEFSDASRPFILSHAFPVKPIENSSDISVADAKLKNAVIVQRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFC9</accession>
    <name>G3BFC9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_116047</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the mitochondrial lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFC9"/>
    <dbReference type="STRING" id="590646.G3BFC9"/>
    <dbReference type="GeneID" id="18248143"/>
    <dbReference type="KEGG" id="cten:18248143"/>
    <dbReference type="eggNOG" id="KOG2484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_5_5_1"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000006">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000844">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="167"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV60988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="516" mass="57539" checksum="1FFF241A75B4261A" modified="2011-11-16" version="1">MRAKKQTSKRTSTRMREGIKKKASAKRRKDRKMSKKDVTWKARGTRDPGIPASFPYKDKILMELEEKRQIEQERKEQLKWQRQQEREEALSKGEAINMEDSSDDEDQGNGMAALLESAQQAAKEYDGEFDVNDDDAMVDSEDDVEYDISMDEDEDTNSELDKSRKAYDKIFKTVVDQADVVLYVLDARDPESTRSRKVEEAILQNPNKRLILILNKVDLIPTDVLNQWVTFLKSMFPTIPVKASPSTSSTSFNKNLTLTSTANSLLQALKAYATKANLKRSLIVGVIGYPNVGKSSIINALTNRHTNNSKACPVGNQAGVTTSLREVKIDNKLKVLDSPGIVFPDEIFNKKQSKSAQEAKLALLSALPPKQIIDPIAPLNMLLKKFSKNAEMAEGLKNYYNLPSLPANDFNEFSKQFLIHIARTKGRLGKGGVPNLESAALAVLNDWRDGRIVGWVLPSNSKANAASAEEAIDSNVPKSSSRGEKEPPKVEQTTVVSTWAKEFDLDGLLNDNFGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFM7</accession>
    <name>G3BFM7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_116080</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFM7"/>
    <dbReference type="STRING" id="590646.G3BFM7"/>
    <dbReference type="eggNOG" id="KOG1317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="433"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="488" mass="52277" checksum="F28ED7FC8F20F4B4" modified="2011-11-16" version="1">MLRLAASKTTLSSLARSMSSSAPRLQTRIESDAFGEIEVDATKYYGAQTERSKMNFKIGGAQAVMPTPIVRAFGVLKKSAAIVNEELGALDPKLSEAIQQAATEVAEGKLDDHFPLVVFQTGSGTQSNMNANEVISNRAIEILGGELGSKKPVHPNDHCNMSQSSNDTFPTVMHIAAVTEISGSLIPELTKLRDALQAKSDEFKDIIKIGRTHLQDATPLTLGQEFSGYVQQLTNGIERVEKTLPNLLFLAQGGTAVGTGLNTRIGFDVKVAEQVSKLTGLPFKTAPNKFEALAAHDAIVEASGALNTVAVSLFKIANDIRYLGSGPRCGYGELSLPENEPGSSIMPGKVNPTQNEALTMVAAQVFGNHSTITFAGASGQFELNVFKPVMISNLLTSIRLIADGAASFRVHCVEGIKANEDKISKLLHESLMLVTALNPKIGYDAASKTAKNAHKKGITLKESALELGMLSEQEFDEWVRPEKMLGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AVZ4</accession>
    <name>G3AVZ4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_128831</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AVZ4"/>
    <dbReference type="STRING" id="590646.G3AVZ4"/>
    <dbReference type="KEGG" id="cten:90982002"/>
    <dbReference type="eggNOG" id="ENOG502RYCI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016553_3_0_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021752">
        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="Zn_ribbon_RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="RRN7-type" evidence="11">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="12">
        <location>
            <begin position="95"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="13">
        <location>
            <begin position="228"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="475" mass="55318" checksum="90C8BFF9B5340911" modified="2011-11-16" version="1">MSQSWIRGPVCGIQNCPSRLYTSSDGHKICQYGHVLEGDIEINDDDGEFTQTRRLQMKVNEVGNLVHTSQVDHGHKRESKRFTGDHAKEVCLKCLQIILKAQVAAIVKEMYHNDVIFRSELTTVVKLNWTKLLESYIRRDSFNTDDGDVPRFHIKPRTRLPGVLDLVFVVYYSILQLNCYPIYLSDLIKLVASNKVPALRTHHILPKQYVARLGSEYHATLHLQYLTEHLLYSAHKTVYKRLAIKNLSRSINYYYPFILKIYFEELLLPNAMELFVMVDALMAKLRTKFTFPRIQKHMVPDVLVVCLMIIVVKIHFAYLNNKMDHQEWINNVASVNTDNNKLDFVNKSNKESVFNLAEWSDSKISTYCSYLNDIYLKSNVQTNERSHQNAIMMDRLFQIFSTDESEFPSSAPSEDTDLNTCLKSYAKADLQRITPKEIHVIEDFLFVKFAGMFHMSIDKFYKHYDYAEQLVHKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW82</accession>
    <name>G3AW82_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW82"/>
    <dbReference type="GeneID" id="18246398"/>
    <dbReference type="KEGG" id="cten:18246398"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_0_2_1"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="328" mass="37903" checksum="76EB23432A712C9B" modified="2011-11-16" version="1">MSKPSLLIPTEADYADAHEDEDQEILYRQRIDELRQKTGAFRWRFEVVKGFFKQAEDATDDFKFNYATEDFGRLKSWDQTIADLKELNLKAPGNEAYKLLFLARHGQGFHNVVINKYSYEEWYRKWYKETHDGDVEFAPDPMLTDLGINQAKENHELWKHQLAQGAPMPSKFYVSPLQRSSHTLAHTWTGLKPQGLQPVVTEGLRETSGLNLCDRRSTKSVIQQRFGQYGFVFEDGFTEEDEFFDAHNREKLHEHCIRTNRFLQRVFDEDYNIAVGEVAKQSAVANTFISTTSHAGTIRTFITVLGHRRFTISTGAMIPIVVRGIRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWA9</accession>
    <name>G3AWA9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112214</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWA9"/>
    <dbReference type="STRING" id="590646.G3AWA9"/>
    <dbReference type="GeneID" id="18246404"/>
    <dbReference type="KEGG" id="cten:18246404"/>
    <dbReference type="eggNOG" id="KOG3103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074741_3_0_1"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="107"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="254" mass="27386" checksum="5C80E01AF02521B3" modified="2011-11-16" version="1">MAYYQPTNPTTANMDFYQSNYQNNYLANPSQAAAAGAMGSMDGGFGTGFDISGSMGNGELSSGLLAAFGTSGYPNEPPLLEELGIKFQHIKAKTLAVLNPLNQNITSDIMADTDLAGPILFVLLFGMLLLLAGKVQFGYIYGVGLFGILTLHFLFKLMSDKVQIDLLRSASVIGYCLLPLVLISIVGVFFSLDNSFGYLLSGIAVTWCTYSASAFFVVVLRLHNVRALIAYPLALFYTVFALMAIFVEKEALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWF8</accession>
    <name>G3AWF8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112250</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWF8"/>
    <dbReference type="STRING" id="590646.G3AWF8"/>
    <dbReference type="GeneID" id="18246426"/>
    <dbReference type="KEGG" id="cten:18246426"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="505" mass="54307" checksum="503398B43D84B57C" modified="2011-11-16" version="1">MSSATDFPGTGDGGDVFELNLNDQFDSGDMVWVGTSAALVWIMIPGIGLLYSGISRKKHALSLLWASMMAACLTGFHWFFWGYSLVFSHGGNESVFLGTLNNFCLKGVFGAPGVVTTVPDILFCFFQGMFAAVTAILMVGAGCERARLGPMMVFLFIWLTVVYCPIAYWTWGTNGWLFNLGALDYAGGGPVHENSGFAALAYSLVLGKRHDPVATGKVPKYKPHSVQSIVLGTVFLWFGWFGFNGGSTGNSSIRSWYANVNTNVAAASGGLTWMFVDWFRTGGKWSTVGLCLGALSGLVAITPAAGFVPVYFSVAFGIVPGIVCNFAVDLKDYLQIDDGMDVFALHGIGGYIGSIMTGLFAADYIAASDGSVAGDASLRIAGGWINHHWKQVGYQFAAATSTGLWSFVVTALILYGMDRIPQLRIRLHEDEELLGTDIAQIGEFTYHDDEEAADHEAYVIEPIRSTDARLAKLKADTSNNVNAEELVGESPKVDGSDSDNKSKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWG1</accession>
    <name>G3AWG1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 2-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_101043</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWG1"/>
    <dbReference type="STRING" id="590646.G3AWG1"/>
    <dbReference type="GeneID" id="18245432"/>
    <dbReference type="KEGG" id="cten:18245432"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_3_2_1"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="60"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="618" mass="71088" checksum="5E8209F915D280D4" modified="2011-11-16" version="1">MDRPALEIPYQLQKKFEKTASLEKLKTLLTKSKMKKSYTSINIPGQTSSKTSPDGRIASVDVGSKLVIVMVGLPARGKSYITNKLTRYLNWLQHDCRVFNVGNTRRLDIANNNGPEDKPLPDTHTPNNEINSPEHHGNSPKSPNHDADFFSPDNSTYTALREKWAMDTLDQLLDWVLNGNGSVGVFDATNSTKRRRSRVLKRIQERSNGELKVLFLESICTDPAIIESNIRLKLSGPDYKNMDPEVALKDFVGRLHNYEKAYEPIDEAEEKLPGFQYVKMIDVGKKVVSYNVQGFLASQTIYFLLNFNLCERQIWITRHGESVDNLSGRIGGNSPLTKRGHRFSKTLAKFMNFQRQEFRKKQLKQFSDRLELKYNDLLKKGLGDFDEDDDTLNQIPSEPNFYVWTSMLTRAIETGEYFDDQVYSIKEMRMLNELGGGKFEGLTYEEIQGKYPKEYQARIQNKLTYRYPGVGGESYLDVLTRLRPLITEIERLTDHLLIVSHRVVLRILLAYFLNLDRSAIGELDVPLHTLYCLESRPYGTEYHMYEYDETLDWFVKVEPDHQKNVKQVGVLYKQRKYSVVPTAPPRNKPDVMSVRRTSTVAGRAPPPLRRSASQGFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWW3</accession>
    <name>G3AWW3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_91802</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683893.1">
        <property type="nucleotide sequence ID" value="XM_006683830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWW3"/>
    <dbReference type="STRING" id="590646.G3AWW3"/>
    <dbReference type="GeneID" id="18250114"/>
    <dbReference type="KEGG" id="cten:18250114"/>
    <dbReference type="eggNOG" id="ENOG502S7HF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142408_1_0_1"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12315" checksum="1F141A069DD5A22F" modified="2011-11-16" version="1">MGWFSSEVQAPPDKNKRQTCWDSRDRFFECLTAHGIDNSLDAKQKDAVENNCGTLRTEFQNNCVASWFKYFQEKRYNDITRERYIKKLEAEGAQELPFKLAPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX29</accession>
    <name>G3AX29_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112416</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX29"/>
    <dbReference type="HOGENOM" id="CLU_2037758_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="121" mass="13454" checksum="1446C54BC1A3E862" modified="2011-11-16" version="1">MIEENSFSHKRFQHLYAVDFIFVDVDTQTAGPVDQVHLEVLIEQVDRPVKNSIVDVIVTDTGAVQVADYVVPVVVFEVDPVIESGESQLTHLVDVVIQLITPPKDIVQCVCIDIIELDGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX75</accession>
    <name>G3AX75_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_132963</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX75"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011607_0_1_1"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="93"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="408" mass="46552" checksum="59E0EA7E7837550D" modified="2011-11-16" version="1">MSYRGKEKAGSEIPLYHTAPGSDNRVGRFVFKPRASWKQLLSLQDAKVIGLIMGSWVILVHLVERTHVRYVINKCQWKNWENWDKKTGIVPHRVALVADPQLVDDNSYPDRPDLLNYFVKKICDNYLRRNHRFLQRLLDPDSTIFLGDLFDGGRDWNDQLWFEEYERFTNIFPAQPHRITIKSLPGNHDIGFQTIDPLRQKRFERFFGPPNDVVTLGNHTVVLLDVISLSSESKDINRPPHEFLQSLPATMEKNIPKILLTHVPLYRDNQQQTCGPKRESPNPFPVKKGKQYQTVVEHDLTSEILDTINPCLVFGGDDHDYCEISHQLSHGLSAKEITVKSVAMSAGIKHPALQLLSLHNPVDAEGQSLAALPTYSTEMCYLPSPLAGITLYVIWFSISIIVLGLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX96</accession>
    <name>G3AX96_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_91895</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683982.1">
        <property type="nucleotide sequence ID" value="XM_006683919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX96"/>
    <dbReference type="GeneID" id="18250126"/>
    <dbReference type="KEGG" id="cten:18250126"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF29">
        <property type="entry name" value="FAMILY TAURINE DIOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="75"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="355" mass="40089" checksum="8D7FB821F2BD05E0" modified="2011-11-16" version="1">MTFDFKLPEQLQALFPDYHTPNETSPYEYAKAQGVQYPNYTPWKMEPLEEIKDIEEKGKLASKDKSSLLNAATSVRNITPLTGTEILGLSLAKLSDSQKNDLAKLAAERGVVVFRAQDDLDIREQVRFGSYFGPPHIHQESGIIPDIPWVHAVYKDENSHKGLRSQVWHSDVPYELNSAGLTTLRFDTIPSQGGDTMFANGYAIYESLNPGFRAYLETLSAVHSGYGQLSIAQSEGRTTRRPPLETVHPLVRTNPITGLKSLYISENFTTAIVGLEKKLSDVLLRYLFDYVNNALQFQVRLSWGKHDVAVWDNRSHFHTGVFDYYPEVRHGTRVIALANKAYFDPNSKLLSEYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXB1</accession>
    <name>G3AXB1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112077</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXB1"/>
    <dbReference type="eggNOG" id="KOG4614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047290_2_0_1"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30963" checksum="DEF8C770AFAE5CA5" modified="2011-11-16" version="1">MNFTRYNSTKVPRFLKTIAETSKPPLTKSKVVNKPFGLPVPILLNPKSNSKRSLRNEFLGSEAKEMRQRQLDHDIKHSPFYESKSFTNTNGKIFSPPISYFKADKSLFFPNFNGNVINGNETQIHKLFKDKVSLVRVFSTVSGEKCTETYFKSVDGVDYLKDYEQFEQVYPKAQVIDINIPIGWAKRLVVSLAKPGIKKSLPVSRQNTYFVLPDSLFSYDIKAELNCDNSCSGYIYLVDSEGRIRWATSGYASDSEKELLYKCLSGVTKELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXK4</accession>
    <name>G3AXK4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_128824</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXK4"/>
    <dbReference type="STRING" id="590646.G3AXK4"/>
    <dbReference type="GeneID" id="18249340"/>
    <dbReference type="KEGG" id="cten:18249340"/>
    <dbReference type="eggNOG" id="KOG0104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_0_1"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013152859" description="Actin-like ATPase domain-containing protein" evidence="7">
        <location>
            <begin position="16"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="861"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="105402" checksum="8F9414ED4A4B8FB5" modified="2011-11-16" version="1">MKFFIAFYLLTLSLAAILGIDYGQQFTKAVMLAPGVQFEILLTEEARRKDLSSISIRPEKNGEIERVYGSAAQSLCTRFPHHCIGGIKSLLGKSFQDRDLSDYLSTHFGLKAIEDEDRTNAIKFDLGFANQSFAFSVEEVLAMTLKELKNRALKNLDENPVAKAIVDDVAISVPPYITQEQRQAYIDALEIAGYKNILGLVDEGTAVAINYASNQKYEQKDYDNKKKFHMIYDMGAGSTKATLFSITPFSNLTTKLELENIGFDVAFGGQALTQSIYNILIEKLTSSFGLDEDFELPPRAAARLLEGAEKAKIILSANSDYHLSLESILDEKDFKAVITREEFEEINIDNMVRITKPIMDALHGTGVSINELQSVILTGGSSRIPFVQKHLATLLGEQRIAKTVNADESCALGTTIKAFREKTSFSFNKDFVVEDKTYHNYEVSVNGEEFSVFEKGTPADSTKRINLGELIDDLSIELFEDGRYFKGYTVENVLDKTSSLTCNDDKAYKKQIFATFTLDSNKIFSFTKLEVECIKEGKDGFFKKFLNKEEPVDFEEEAPEAEENESTNSTASVNATDSSSRKSRKVLRPVSISIPRPQYPSLKPMSRPLKQRVTSKFKYLDSRDEYKIALDNTKNRLEAACYQLRNLIDEHEERISDELSVDNFRELVSETIEWLEFDSDDSPLSEFEDKIRQIQIRHDEIHAITKMSTTDLSLEGMTKLYEEGSSIMMKIQSKMLEFGSSISEIRQKYDKEGLDFDKENDRIKLQLLSKGEDKMMRLDRSLGKYKDLLTQLGETVQLNEKYFNKIAKRELFDTYEAMTESIVQMLADLVMLDESHQERMQLFNTKFEKLVERKKQKEFREKLKQEKANADGEKQGEVPIQEDEDVEHEQTEQTEQTEQETQQQDNNAENSFEPVDEEIVHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY14</accession>
    <name>G3AY14_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_92073</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY14"/>
    <dbReference type="STRING" id="590646.G3AY14"/>
    <dbReference type="GeneID" id="18250152"/>
    <dbReference type="KEGG" id="cten:18250152"/>
    <dbReference type="eggNOG" id="ENOG502S7ZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025507_0_0_1"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="672" mass="75662" checksum="A1A4108BAA437189" modified="2011-11-16" version="1">MSETTATPNSNPPANFHSDTLHTQKDTDKPSAKELKNQAKKRRKRNNRKKNKHPVPAPLEAAIPVEPIPNIDIETKPPELDCPVMPVHNLQISPRDPISPRRQTIMRYKKSDDTISSGLFINEAKGNLKSNSSTLGDTSHEQTSRKLKTNHVGEKESLFKFRSARILVFDEEIGESKNSASATSGRLLGHGEFEIFQLHNGDVTYLSCGPSFIYPLLPKLKILRIAFNQFILPLVNPERYWKIFINSDNSEIIESLGDTFEQVVKYRNLTIGADPPKNNKNGDFKLPVTPKTVMEDSVLNFNMNHISNEIPESPPSVPLSPHQNGQVISGSLQLGSPLKPPQLNSQFHPMSNLISRVDSDKSLSSALASLDVAGISQVPGINNTTIKVHHPKPKRPLVPYASPRINSARHDTKSDSSMDSLLDEYEESMSVSKSFTYTKSRPMSRSSSFVQAPANFKRKEHSMYDEKKEEDSMLHYKKAFDSDDFPTTSLSEYNKTHNIRSRRSSRSELYTSESNWMDPDPKANAEVIPRFPYSRSSYSVHSGHDLNNGDLNNTYKNIYKSITQRNLSQILNDRNDDLRSVRSSQRLPTIEQSRTLKTSTGSVRNDYVNTRYGDQKLAPSTSLNYNPSTKQPIKENIYLNSDDVYKILSKKKASTAEPGPRSKGFASRLFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY19</accession>
    <name>G3AY19_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_112609</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY19"/>
    <dbReference type="STRING" id="590646.G3AY19"/>
    <dbReference type="GeneID" id="18246603"/>
    <dbReference type="KEGG" id="cten:18246603"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF3">
        <property type="entry name" value="TRANSAMINATED AMINO ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="10">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="9">
        <location>
            <begin position="448"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV66159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="69587" checksum="2F2B93DB6B5A8050" modified="2011-11-16" version="1">MTVTDRIPLGEYVFLRILQANPKLKSIFGVPGDYNLNLMEYLYKDSVLDKGVTFIGNCNELNAAYCSDGYSRIIDTFAVMITTLGVGELSALNGVSSAFSEFVPVLHIVGSVATGKEKVNNDASIDDFQNWHHLVQSKDPLSKPDCHVFSKMSEPISICTESLTHKGLFNGDNFDKIDNVIKSILRESRPGYLYVPSDLPDILVPASRLEIPFHYKEYDPENIESRYRLNTLSDKILTYLYQAESPIIQSDDLIYKFHAYDSFNGLIDKLKNNKSVRLYASRIGKCIDETLDNFVGIYPSAFPDVADNFQNKTDLLIVFGYTNFETNGLYNGLEHYKNIRDVILINPDYVKINDEVIFIKNQKNGLRNFCLNDLIQNVSDKLDVTKLRQMDNIPKFNRNKVTEYPDNDTQDMRISSNKLFNFANHNLRPNDIILCEVSSFSFDLPNLTLRKNNRLIYNSYYASIGYALPATLGVCLALKDLGSDRRVTLFLGDGSAQMTIQELSTFLRFNVSTPQIFLMNNEGYTIERAIKGETRSYNDIQLWNYEFALKFFGDINEEKHTFHKLKNSGEFEKFFACRDEKSKNKLEFFDLSMYKTDYSGGLKFFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY89</accession>
    <name>G3AY89_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_133212</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY89"/>
    <dbReference type="STRING" id="590646.G3AY89"/>
    <dbReference type="eggNOG" id="ENOG502SE2D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_322623_0_0_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF88">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="897" mass="104302" checksum="EF37A1B4B50EC20D" modified="2011-11-16" version="1">MAETYPISCISCRRKKVKCNKHKPCNQCKKRQIVCQFPSTFRNIQIKENEYDDKLDNVATSQFDNHEGDNQSMKIKKLNSEKAEILNKNYQLNEHVKQLTKQLESMNVQSNYFIEDLENSSSSDPSKSSKPPSTYKPESFKISGETSELGNKYYGPQSSSFMIETLKNTQFINDNNSSRNYLDIDSDIKFEGSLIKKPLPKLKPGISTSENLNIIYRLVEKFFSNLSSNYYKTFISKHQLLDFVRDYPNIDNNIWENDDDLLLLIMVLIISIIRITPVELRDIFNLPSSECGAYIDNLIHNDLIYNFEKLRHNLVNESTLTIQSYILCTEYYFIEQRYEECWSMMFHTCSIAYSIGLHVTQRLKLNKLNDIDLNTNIDTTLDENEYDEMEDITKLKIWFSLRILSDKVCSVLGRPNPISFQVNSIILKYNQNYSNINLRKNTTSILLRIGLSECLRLSNMMLIENFMIDFTMTDLLNLSSEFEKEIYLLELYLTEIENDSSHASTEIVSSTTSNSSGGHGGVSEIVGSVSTSYEINDSNGSDGHDSFNELSYDESNYLPIKIEKIDLLNDLVVFYINKAKLFEPFIVKFNKADDDSILILTNLTNSIINFLKLIITIFREFEEKISKKRVYYLKVGKYFRINFPFLNSFIYQGIVIIFTMLNYKSKDFAKLKFNEKFDNQGFLKSLKSQLTILLDINQSFEERIWSINTIYLINRNLGLIESIEKHIYQNNFDEEFANALLNQPNFQQQQSQSAANNLGIINGSPISINSNTQCTSNYLMNFNFNDPFWITNPDNLPYYLGSPNQEFHNQAEEETKHNNFKDMEIDSESRGSFRSTQFIQNQTHHEQPLTQPGKEFTSLNDQFNQTQIGKPKLSFDEEKHKKIKLDDFIHSEFDKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY94</accession>
    <name>G3AY94_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein RMD9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112666</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY94"/>
    <dbReference type="STRING" id="590646.G3AY94"/>
    <dbReference type="GeneID" id="18246626"/>
    <dbReference type="KEGG" id="cten:18246626"/>
    <dbReference type="eggNOG" id="ENOG502QUSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4081443at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="71715" checksum="73527B61B0522F9A" modified="2011-11-16" version="1">MFRFVSANARQSLRPVLLQNLGNNSGIIAPPPVPFTTPANGYSKFQRFNSYAANVSQPSKEHIEDYVSKLQEDPLVGKAIRDEAQIKLNYFKEQVVLFDQYKKLSDVEGRRAFSETFHNILNSFEDNELRSIFSTHDLRRYVAALNFSIYHNRTSRLASNKNVDRDQYSSSTSIDEVLLKKALLRFNDVLMKGELKNILNADSLVLYFNAMNQFQFYTESIDAWEQGVNDNKIGGIYLSEKVLSVVLPIAQKIERFSYEEICRIYELNTAKASDISPQLICSMGKISIAAGDYKKGLDFLESLLKYFEERKHNPSNANYYLGDLHLSFIGSCDDVVVAKHFFDKVINYDLPYMVKLKVPYVQKLMENCHKNNESLDTILYFWKATVHHYATDKRAVEINSRYSNLNNTMFKIFFKFYPELTTESFGKLKEIISDFNSIKPVDEIFLNTLITNYAWKDKVVFNQLIDNYTVFGINRTQVSYRVCLKKIGEIKGFTHEEISQKWSESLESLDEKRFKYIPNADWASIRDATIWSKEERDERIDLYWQIVHQYKNFMQDKSTCIRFVRNWMKNEHGYEDLKNHVVNGKDSELQTPNFKNLKRSVNFDQVFADTTNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYU6</accession>
    <name>G3AYU6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101245</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYU6"/>
    <dbReference type="STRING" id="590646.G3AYU6"/>
    <dbReference type="GeneID" id="18245450"/>
    <dbReference type="KEGG" id="cten:18245450"/>
    <dbReference type="eggNOG" id="KOG3435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144297_2_0_1"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="97" mass="11220" checksum="2C20C2ADB34DE779" modified="2011-11-16" version="1">MFRSLTVVRRFSISRSSLNTPKSSCVAGTVLNLKVKKAGDEPVALEDSDYPDWLWDSLDKGKKDKTLKKNDFMKWRRKQLNKVNTAKIKEKNFLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYV3</accession>
    <name>G3AYV3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_118876</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYV3"/>
    <dbReference type="STRING" id="590646.G3AYV3"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442654" description="candidapepsin" evidence="15">
        <location>
            <begin position="19"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="16">
        <location>
            <begin position="69"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="351"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV65937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="441" mass="48082" checksum="2F9D2B8AB2789FFB" modified="2011-11-16" version="1">MFVRLFWVVFLFTVPVLCGDGYYKLDFAIRKGSKLTDVVKNFMEELDSSFTKRDGNGTLLDLENESAFYIASLSIGTPASEVKVLVDTGSADLWVMSSKNSYCSSNGGSMDCSTYGTYSEDNSTTFESNNSDFSISYLDQTFAKGTWGQDTVELTDDLVIEGANFAVADSTDSNVGVLGIAYTQLESADTVYDNLPVQMKQQGFIKKVAYSMYLTSAERNTGSVLFGAIDHAKYTGDLVSFDVVPKNGQNVYLQITLSNIQVTLVSNSTESSSVVPTTLASSVTSSTSPHPTIAAVLKKREATIDTQDVDALFDSGTTLTYFSQDVLDSILAAIDPSAEYNSNIGGYQVPCSLRQEGNKFTYNFDGKREIDVPLSDMVMEVGQNGTTGQIICMLGIVSGDTTILGDNFMRHCYSVFDLEDNTVSIAQMNYDDINEDIEIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYY4</accession>
    <name>G3AYY4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_92306</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYY4"/>
    <dbReference type="STRING" id="590646.G3AYY4"/>
    <dbReference type="eggNOG" id="KOG3869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025093_3_0_1"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="195" mass="22949" checksum="A9895B4701341A88" modified="2011-11-16" version="1">MPGDLNLKKSWNPALVKNQTKVWKKEQETLNEFRKIKEREEELEKEQQTLGLIGLKYTNNNELSKSDKLKLNKLDWMYDDPTGGTKEATQVPKPVPTVIKTNNIDKTKRRLEELDPMASIKKNMIQKRQDSRDRSPTRNNERLESHKHRHSSSSSHRDRKHRTDSHHSRHRSSTSKHTSRGRDAKEEPKKPIIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ51</accession>
    <name>G3AZ51_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_129438</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ51"/>
    <dbReference type="STRING" id="590646.G3AZ51"/>
    <dbReference type="GeneID" id="18249381"/>
    <dbReference type="KEGG" id="cten:18249381"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_1_0_1"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="29"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV66010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="387" mass="43472" checksum="BBECB7B92147C985" modified="2011-11-16" version="1">MFGKLSHALNRSPSHNKHTHAESNPHGEGITGVYFSNWSIYERNHFPTDIDWQWVNHLYYAFLSIDTNTGSVSFSDTWADVEVPLPSPLDPSKKVHGLVAQLRQIKQLHPQLKIMFSIGGWGYDHTFEAITHDARKLDTFASQCAKLVIEHGFDGVDIDWEYPKTAAQGQLYCRLLETLREKFCEISPSLLITAAVPGSEEYIRHLDVKRMDNSLDYWNVMCYDFTGYSWSQKTGFHSNLFGANGDTDLCADVALKSYGSRGVAANKLMLGMPLYGRKFGGVEVPGIGQSFDKQKFSDEGIIEYAKLPLNHSKEVFDPRKVGAYCYDPTTKTLVTYDNVDSAKVKAVQVSSRGLAGGFYWDSAGDKHGELIRTFSEMLRHSNSTSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ58</accession>
    <name>G3AZ58_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_101229</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684587.1">
        <property type="nucleotide sequence ID" value="XM_006684524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ58"/>
    <dbReference type="STRING" id="590646.G3AZ58"/>
    <dbReference type="GeneID" id="18245448"/>
    <dbReference type="KEGG" id="cten:18245448"/>
    <dbReference type="eggNOG" id="ENOG502T63W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2454497_0_0_1"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="89" mass="10631" checksum="CA25EBA8AC7DACB1" modified="2011-11-16" version="1">MRPSPVALKSLGPTLSLEEFLFRQQIKGIYRKVVRSIYKHHERDDLMKFLRYEFKIKEKHDLAYRKYLLSQGTQRINDMAMMLGLNISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZC5</accession>
    <name>G3AZC5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101323</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684634.1">
        <property type="nucleotide sequence ID" value="XM_006684571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZC5"/>
    <dbReference type="GeneID" id="18245457"/>
    <dbReference type="KEGG" id="cten:18245457"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58886" checksum="109B139C4A683B9B" modified="2011-11-16" version="1">MSDSDIKQPETVLTTVLSGDYKHALNEEIARVISPGGKEIKVTADVDEAMEIALESKDIVLTPEEDRQLLRKIDLYLMPFFTFMYAVQYMDKITNSFASIMGLKTDLGMVGNTYSWLSTAFYLGYLVFELPASLILQRFPVAKATSAFMLLWGIVVCLAPAANLPGFMFLRVVLGMLESSITPAMVILTGQWYKRHEHFMRTTVWLSACSLGVIIGYAFAYGLYIHGSNWSVASWKVVYIVIGLVNIVMGVAFYFHIPDNPTKAWFLNDRERLMVVERIRSNNQGFGNKHFKWSQLKECLTDYRIWLMFVFQILDEVPNGGLTNFSSILLNDDFGYSVKKSLIMNIPVGVVGFFGSMLVASTYEFGLVKHRMAVSTFALGVALMGSSLLAFADSKTARLAGFYVMQISDIGFICMLSIYQSNVAGHTKKVVGNALLLIAYCAGNCIGPQTFRSNEAPHYKSAKGAIVGCYAACIALILVLYYSYYRENEARARKREEMGDAYVKLENIEFADLTDKENPEFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZE9</accession>
    <name>G3AZE9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ACF3</name>
        <name evidence="10" type="ORF">CANTEDRAFT_112939</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZE9"/>
    <dbReference type="STRING" id="590646.G3AZE9"/>
    <dbReference type="eggNOG" id="KOG2254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005482_5_0_1"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000008">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF20">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="339" mass="37855" checksum="C9F87F6E78AB6A57" modified="2011-11-16" version="1">MNSNYYSGKVIDKYANILLVVHDIIGDTDSAKDILSDLKTAFKVFTKNTQYYPLIYDTKFGGVTSSASQSGDTGADFGSGYYNDHHFHYGYFVHAAAVVGYVDKQLGGSWADDNKDWVNSLIRDVANPSEDDTYFPVSRMFDWFAGHSWAAGLFASGDGRNEESTSEDYHFSYGMKLWGSVIGDSSMEGRGDLMLSVMNRAMNKYFYYSDDNDVAPSEMVPNKVTGILYDNKIAFTTFFGDGDEYPQYVHGIHMLPMDAGAASIRGEEYVKQEWEETIASFVDSLTDGWAGILRLNQALFDPESSYKFFSSDDFSSTYLDNGQSRTWSLAFSGGLYNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZG8</accession>
    <name>G3AZG8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112953</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZG8"/>
    <dbReference type="HOGENOM" id="CLU_3106159_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="51" mass="5718" checksum="00A8828D6AAF4930" modified="2011-11-16" version="1">MDILGIKVAPFLKVILCNTNLENGPPRPRTPNHNIPLYYSFPGAFIHISRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B091</accession>
    <name>G3B091_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113065</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B091"/>
    <dbReference type="STRING" id="590646.G3B091"/>
    <dbReference type="eggNOG" id="KOG3219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="117"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV65513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="266" mass="30373" checksum="264D4FED13C5202B" modified="2011-11-16" version="1">MPIQKVAKCDPNLFFTSTNMSHNPDEPTAGTDDSDMSDVSLDEEDEEIIGRVLYGSIAHQTDDDVLRISDDDHSSASDISDTELEQINDPALVSRYKRLREMKVDKDLGEEERKRLIMANFNNDQMDRFEAYRRSTINKPGVKKICNGVLGHSIPPHLAIILAGLSKSYLSEIITKAFEVQERENKAKLIMDIEGKKKRKRQTLRNIENGKDIEVSNSRLTYDGDTQSPLRPEHIREAIRLYRHENSSAIQAQWRAQGDADGWLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0Q1</accession>
    <name>G3B0Q1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_113204</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0Q1"/>
    <dbReference type="STRING" id="590646.G3B0Q1"/>
    <dbReference type="eggNOG" id="ENOG502SD6I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645755_0_0_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV65573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="457" mass="52945" checksum="9D80DE145ADF6724" modified="2011-11-16" version="1">MPKISRTKDGCFGCRQRRKKCDLQRPKCKFCSKYNKECQYPTYPKQTLRSFLSGNHQPYNLEHNQVILKDYIDFNTLSEEYIDELCLKVFREHFFATLVQPAWVKANLSAMIEADNACACHKQVTICVGSAYLSKINPQFTEIARRKYVDMLTSIKVAEERQELKWDEGFTFSIVQLLLVRDSIEGTKNHNQTISHILMAYTIVCKILQTSKEVQRYERALLESFVYHYSFNYVFLDLKIPCPNEVFSLVKDALQPEFWSSTSVILGCIDGFALVAKASHLLLVSLQGFNEEVVQEAEGLIKEIDDYDYEHLKWRMSVNHSSSSPYYPRDIEESLVFSKVLSSSAKLMLLKVYDNKTKAEDPKIQEIVGFIIHCMTTMEQSKQFSLSLLLWPSMVCGFCCTKAEDRGFLSRVMQKEALSSDFNTLPVSFLRKCWQDELGIDAMYLWIKENQYDSDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B197</accession>
    <name>G3B197_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_121094</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685721.1">
        <property type="nucleotide sequence ID" value="XM_006685658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B197"/>
    <dbReference type="STRING" id="590646.G3B197"/>
    <dbReference type="GeneID" id="18248824"/>
    <dbReference type="KEGG" id="cten:18248824"/>
    <dbReference type="eggNOG" id="ENOG502S9SB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137480_1_2_1"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="113" mass="12696" checksum="4D529C552FD313C6" modified="2011-11-16" version="1">MVSPHKIFYKGEENDFVVFVEDREALDKFREDSSIPLVDVISVFQVFTNRQGGVEGQLLQASKTELENEFGTKNTDEVIKKIVLEGSDKSNASINNRKFNSHNDSMGPDAITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1J1</accession>
    <name>G3B1J1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_104290</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1J1"/>
    <dbReference type="GeneID" id="18245707"/>
    <dbReference type="KEGG" id="cten:18245707"/>
    <dbReference type="eggNOG" id="ENOG502QU6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_1_0_1"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442797" evidence="6">
        <location>
            <begin position="29"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="12"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="413" mass="44904" checksum="2D93FB3A4F3B2B53" modified="2011-11-16" version="1">MTLRNPPKNFWRVIAISIWILVLGAADATPGALLPQIEAYYSLSYSLTSLIWMGNAVGYVFVACIASKLDTVLTLRNLLTLGTVCAMMMYSLVSSGTKFPVIVLGFVCGGIGSGVGISRANVFLSSFGERSSMYLSIGQSAYGVGATISPLIATGFVGADISWHFFYLVLLGCMMVSSIMIFISFSGSEIDMAPWENDGSEDIPNDHKVKLKAALQTKATWLFAVFVFVYQGAEVSMGGWIVTYLLDYRNGGHVVGYVASGFWGGVALGRFILVRPLHKHLGSRRSVIVCSLMSLLFVTLTWVISNVVAAGVFVSLAGFFVGPNYPIMVTLASEMLPRKIQVISLTIASAFGSAGGAFFPFLVGLLSQQVGAFVIMPMFIVLYCVMLLLWICLPNRERRLRTTGELSLWQKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1J2</accession>
    <name>G3B1J2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_133767</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1J2"/>
    <dbReference type="HOGENOM" id="CLU_2885559_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="63" mass="7242" checksum="C3B00E972E53FB91" modified="2011-11-16" version="1">MESLKLLLKHQVVSSLPPFLGQVLLLRHTPLSIKTAIRLLWWKFQKQPLLFLGSVLSPRLTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1N4</accession>
    <name>G3B1N4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ornithine transcarbamylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_103261</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1N4"/>
    <dbReference type="STRING" id="590646.G3B1N4"/>
    <dbReference type="GeneID" id="18245615"/>
    <dbReference type="KEGG" id="cten:18245615"/>
    <dbReference type="eggNOG" id="KOG1504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_0_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000017">
        <property type="entry name" value="Ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="10">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="9">
        <location>
            <begin position="161"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="331" mass="36687" checksum="867A299224F32CED" modified="2011-11-16" version="1">MSSVSSSPRHFVNIHQLSADELSALISRAAAFKKQIKTGEPAPWKQYQRLLGKVVALLFSKRSTRTRISTEGAAAYFGASPMFLGKDDIQLGVNESMYDTTKIISSMTSCVFARVGKHQEILDLCKDSSVPIINSLCDKYHPLQAIADMLTIKEAFGNTSGLRLAWVGDSNNVLNDMAIAAIKLGIHVSVAIPSTIKYDPEIQAQTEQLAAENKVTFEIVNDPLVALKNANIIVTDTWISMGEEAEKLEKLKQFANFQINQDMLKKAGVSDNWKFMHCLPRHQEEVHDDVFYSDNSVVFQEGENRLYAALAVMEGFVINKGDLLNAVDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1T4</accession>
    <name>G3B1T4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113289</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1T4"/>
    <dbReference type="HOGENOM" id="CLU_2158062_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="111" mass="12547" checksum="049EC0C3CA7E259B" modified="2011-11-16" version="1">MLQCLRSKTDAGEKGENKSKQETACTILEQLNEFKSQSISTQFEELPESILCVVDDYTKTGGYVNFRINSRVIDWAFAVANGITISGDPKRYWVTRTFVVGTLNLRYSEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1V4</accession>
    <name>G3B1V4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_92771</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1V4"/>
    <dbReference type="STRING" id="590646.G3B1V4"/>
    <dbReference type="GeneID" id="18250229"/>
    <dbReference type="KEGG" id="cten:18250229"/>
    <dbReference type="eggNOG" id="KOG0566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_2_1_1"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF269">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 5-PHOSPHATASE INP51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="151"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1023" mass="117905" checksum="35D1DDAC31D656A8" modified="2011-11-16" version="1">MKLYLNERPRTFVLVSNDSALIVRHPSPTYGKESHSHLSRQNPSNNKNDHTLTKVIVEFVKRDLVDLSRFQELSPSSTLICLLGFFNMKGKVYIAFITKSKKVATPKLGENISAIEAVAFYCLNTDEHDHMLFTEQQEEEKSSNDYPSASMRRFLCNGDFFYSTDFDITSTLQARGFYEKRGDFDRNENTYKLFADSPYFKRFSWNKFLNSELIQFRNRLTPEETLSFDKSGFLVNITRGYAKTVNASIKTKDDALLTLINKQSCKKNGPLFGEWGSDDKGAVSNFQESEIIIYTEYFCFSYTIVKGNVPIFWEVETHFHKKNLISRSGGKEISLTRSFDTSQHAFKRHMDQLMNQFGDVHIIKSIPLDPSNFKSSLGEALEQHIEYFNKQMAKAERNEPKEYEKEQALDPEIEEDKNRFIYFLNHTDIPLSSSTIKKNGYTGANPNNLVQLVVEPMVELGALFYDFTSKSYIGKQLGVFRITTYDSLSKANFLSKIICQEVIQLAFRDIGIIPGDDLLNKHAKLWKECNEFINKNILSFISYSTKLQKSSQASKKKNIKSQVSKRYLNSVIDPKVNETALLKLLGRLQDQTSVIIHNPIHDYIMKELQKNAKLYTSSKEINLFASTFNVNGTMYKGDIKDWLFPPGYDSMPYDLVFIGIQEIIELTASKMVNVDSVNRQFWENHIKWHLNELNPDKIKYMSLWSGQLGGLSLFVFIKSTEISKISQLESSIKKTGFRGVSANKGGIAVRFKYESTEVCLITSHLAAGLTNSDERHHDYKVISKGIKFSRNKRIKDHDVAIWLGDLNYRINLSNEQAKLLIEQKDYAKLFEFDQLNLQMANGESFPFFDEPEIRFPPTYKFDNNTKEYDTSEKQRIPAWTDRILYMSRPNLIKPVLYDCVEDIIFSDHRPVLANFKIKINIENETVKKNLSSEIYDNYITKFGEINDLFINNNNLTYLVDLDANVLPPPSSDSNKWWLVGGLPAKVTIQELNKTNMVINPRCPKNPFKKTEEPEFIQKALLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B279</accession>
    <name>G3B279_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Mitochondrial nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_113393</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573</strain>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B279"/>
    <dbReference type="STRING" id="590646.G3B279"/>
    <dbReference type="GeneID" id="18246936"/>
    <dbReference type="KEGG" id="cten:18246936"/>
    <dbReference type="eggNOG" id="KOG3721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055174_0_2_1"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="18">
        <location>
            <begin position="71"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="17">
        <location>
            <begin position="72"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV65065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV65066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="319" mass="36390" checksum="1B49537BA9C75428" modified="2011-11-16" version="1">MPKLLVNTVAIGTVGITSYFWGLGSKSKTQEKSETKNLPVPYTPKSNLPSSVNPQDFYKYGFPGPIHDLQTRQEFVSCYDRAKRNPYWIVEHITRDSIKSTQGVDRKKSVFREDEQIPVKFRNRLRDFFRSGYDRGHNAPAADAKFSQEALNETFYLTNISPQVGEGFNRDYWAHFEDFCRRLTGKYDHIRIMTGPLYLPKQCADGKYRVEYEVIGSPPTVAVPTHFFKLVVGENNNSDQISVASFVLPNDVISNDDPLTKYQVPVEALENASGLELLYKVPPNKKKDLCKEVRCEIIVREFPKNVNNAMAISAKFDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B282</accession>
    <name>G3B282_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_113394</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B282"/>
    <dbReference type="STRING" id="590646.G3B282"/>
    <dbReference type="GeneID" id="18246937"/>
    <dbReference type="KEGG" id="cten:18246937"/>
    <dbReference type="eggNOG" id="KOG2459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010026_1_0_1"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="56160" checksum="ABAF6B506C80A789" modified="2011-11-16" version="1">MAAPKLRSEKVFWIRKVIALYSIILVVCVGYPWFLYTTSVHRANLPIDDLNDAIQQLNNVRVCTSVFVDAEEDFISQAQLVLDSKLATEHPALNDYWSLKLIPLVDSTILDSREDYQVLFGRVDEPVGASSVTLDDKVLVFEKSFSEMDSRAIQEQLADALVNEVFEQEIEHFEATKSSHPEKSNVVIPYSSKYNLIFSLFVEDGHPVSWDTQTIQDLLSPLLDSLQHYANFTISTQVQYYSKLNIKSEFDEKSNTYKVKESDLSNFINFGDWNLNTNDINPSINFIIYYPSSNHQNLPMVIENSETNSFLVPQYGGLHIFNKKIDILTDDNEVYICDVELIEIMEIFSSQLFKLLGVPSKSSQNLPVRVDALTKLSILNNLQHSIKTLSSLIKLTNELHEISVPELTKDFVNKSLQSVRTSIHYLMSQNFKGAMVESSIALKNSISAFFDKDIVQQVYFPSEHKLAVFLPLLGPLCSILLFSTLRLIKELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2A7</accession>
    <name>G3B2A7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_104212</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2A7"/>
    <dbReference type="STRING" id="590646.G3B2A7"/>
    <dbReference type="eggNOG" id="KOG1137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_2_3_1"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="14">
        <location>
            <begin position="255"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="15">
        <location>
            <begin position="540"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="492"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="665"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="782" mass="87537" checksum="38003A97735AAD2C" modified="2011-11-16" version="1">MATVDSTDDFKFTGLGGCNEVGRSCHIIEYKNKVIMLDAGVHPGLSGLNSLPFYDEYDLSKVDLLLVSHFHLDHAASLPYVMQHTNFRGRVFMTHATKAIYRWLLTDFVRVTSLSSNTSNDPNSGGTSANLYTDEDLMKSFDRIETVDFHSTMELDGIRFTAYHAGHVLGACLYLIEIGGLKALFTGDYSREENRHLPVAEVPSVKPDILITESTFGTATHEPRMEKENRMTRIIHSTLSKGGRVLMPVFALGTAQELLLILEEYWSQNKDLQNIDVYFASSLARKCLAVYQTYTNIMNDKIRSMASSSSYDRKNPFTFKYIKTLKSLDRFQDFGPSVVIASPGMLQSGFSRQLLEKWAPDPKNTVLMTGYSVEGTMAKDLLIEPPTIPSVNNPEMTITRRLSIEEISFAAHVDFQQNAEFIGEVNAPRIILVHGDSIPMGRLKSALLSKYANRKGTDQEVKVFNPRNGDELKIAIKGLKVAKVLGALAEEQIGAEEEEEEKDEDMKDTTEEKENGNKTEDSENHEDDKQEDDDFEVFKSKQVLSGVIVSKDFDLNIVQLQDLHEYSQLATSIVKSKIDLIINAHISLIEWHLQQMFGYINVANDDEDEWECVIMDIISILIDRSKSKGSSNYVTVEWVNDNLMADSLADSVVAILYSIDSSPASVKISSSSHSHDHEKPVKKEEDSNGNTEITIEKSGHMNTDINDRKYRISTLLKAQFGDALKGNDMTNAQIAFGKNEATINYNSLTVTCNSKVLKDRIENIIKRACGLAAPLSQFEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2G3</accession>
    <name>G3B2G3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_133984</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2G3"/>
    <dbReference type="STRING" id="590646.G3B2G3"/>
    <dbReference type="GeneID" id="18249755"/>
    <dbReference type="KEGG" id="cten:18249755"/>
    <dbReference type="eggNOG" id="KOG1458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039977_1_0_1"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000009">
        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="211"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV64667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="342" mass="37408" checksum="DED21ABA0CE0F9C0" modified="2011-11-16" version="1">MASQPHDSVSKQMNVDTDIITLSRFIIQEQIKLAPQATGELSLLLNALQFAFKFIAHNIRRAELVNLIGVSGSANSTGDVQKKLDVIGDEIFINAMKSSGMVKILVSEEQEDLIVFEGGGKYAVCTDPIDGSSNIDAGVSVGTIFGIYRLKDDSKGSIKDVLRQGTEMVAAGYTMYGASAHLMLTTGDGVNGFTLDSNLGEFILTQPKLTIPHSRAIYSVNEGNSLYWPDYIKRYLSDLKEIQENGKPYSARYIGSMVADIHRTLLYGGIFAYPADKKSKNGKLRILYECFPMAMLVEQAGGKAVNDKGERILEILPKGIHDKSGIWLGSTGEVDKFVSYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2R7</accession>
    <name>G3B2R7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_134056</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685549.1">
        <property type="nucleotide sequence ID" value="XM_006685486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2R7"/>
    <dbReference type="GeneID" id="18249761"/>
    <dbReference type="KEGG" id="cten:18249761"/>
    <dbReference type="eggNOG" id="ENOG502SEET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_328171_0_0_1"/>
    <dbReference type="OrthoDB" id="4085524at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="712"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="754"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="876" mass="96898" checksum="8DE0AAA6C32F908E" modified="2011-11-16" version="1">MFRRKSRSVHNVAYTGVNHSAPATSQPNSNALAAALTIGHSLKNNDSTIVRSGSIQQLRPPPTTKSNSLLKRSPSLSNKRTSSFRNFSGDVHSSRLSYDIDDSITESYMDEVTDETTKHYNNHDTVRDLKLRHIPANSPAVRPGAAAHSNPPKVKMVKKYIPTPNGIKIIEVPEAKLQQEISRNNSIRSGANIPRSSSINSLTSPRVSVARRQPSSRLSSLIKSPTLGAMKEEAEASPEQESREYALLEKKIREEKALQKKLEQKRLEYEQLKQRRLVDQQALRELEEEIDHDASHLIHPQIRPTDTSSVSSAYDSDIRSKEVNGLGIVSADTVVDEHEHEVVQKPVLENVTDHFISPTSTNDIVDETDESDYQIHSIDPSSVIVDEFETREVSENAEDSIVEGSIDPSKVLVDELESDKTPKLGQFDSEETPKLGQFDSEETPKLEEFDSEETPKLGHFNGDKTSKLTDEGVTGGDEFGIEEAEFDADDTPVLNKEPKPTFETVPEIINDQPTTTIDGLMAPVVVMNGGSSASSITSDESPTRSKRPMKSAMKNSSSFSVPNNSRRKSNAAHEAYLSLTTAENTRLNSKMSLNDINPVYSQSHHYPTDTASATPLNKRMSTSLRKPPPQAQGGPGSSPGMVKSLRPQSMQIDPSRQANENASPGARMSHRSLRDRSSVYVQPIAPHPALNPNYQSSSQVKAAELYAKANSRPHSTFNAPRKTSFSNEHASPGDSAMRTSLRDHLHQSPPPDYQQHQPRQTNQLKPPQFQGQGEPITPTKPRSSRFVDSDDEISHNGVLSPESPGVFSTRYINSEQEKYSHTVPHSQPQIKTSRQPQIMTLREPPKSKVPDHGSGDKRGKEKKKVGGRLRKLFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B313</accession>
    <name>G3B313_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_105484</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B313"/>
    <dbReference type="GeneID" id="18245815"/>
    <dbReference type="KEGG" id="cten:18245815"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015387_0_1_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="67767" checksum="A7F68D19641AA4F2" modified="2011-11-16" version="1">MDPEWNVDPHAGFDYKRDFFKSFKEFKSEQERKKGVKKSKLKSDYTRTWKDIKLQEQKIHDYVTHLRVFNKCYLESPMESLLNVTDVSRRLFPWLSNKYPRIEDHEGNKLRVVDDASTLHLPFLRRVHDNLNGKGIVLTISDDHVDNTLRLMRILRFHRNQLPIQIVYYKNLSSESRDKIVNFARTKRMQDLGLDPLSEDLPVQTVYFVDVSDSIDPRYLNKFEGFGNKILAVLFNTFKEMVLLDADTVPMIPPEEFFDIPKYQVNGTIFFKDRKAVEYRPENDLIFFKKMMPSKFDTLSFGINQPSNYSLDRDFFHGLNHYMESGLVVINREQHFFHSLVMAQLNFIYPVSARIYGDKELFWLSFLMLGEERFAFNKHFSAAIGDLTPMDERFKDIGKAKKLKSQEVCSNHPAHISDGDDHTLLWFNSGFKFCGQEFDAAKDFDAKKRYTKFKTLKDFEIFFNDKLVIKYAVIPPSEIITVDNTDGESNRSWMNMRQYCNGYTWCAYSSIGENPEPGMQGLVVEYSAEETEFFGVLGDLWMLQVENSVEIEPKEKAGFDLDERKANEIKKEAAYYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B314</accession>
    <name>G3B314_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_104615</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686369.1">
        <property type="nucleotide sequence ID" value="XM_006686306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B314"/>
    <dbReference type="STRING" id="590646.G3B314"/>
    <dbReference type="GeneID" id="18245735"/>
    <dbReference type="KEGG" id="cten:18245735"/>
    <dbReference type="eggNOG" id="KOG0511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022885_2_0_1"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="282"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="554" mass="63857" checksum="2428F83F88C4FF2D" modified="2011-11-16" version="1">MDTFTNLLYACRTGDLETVAILLDTPNLNVNKTDEWDYSPLILASICGHYEVVELLLQRGAICDRDSFEGERCIYGALNYKIRDLLLSYDFSKKVDINQPFASHITGIFTNNKFINKDLVIRCADKTYFVNRFLLAARSPKMMYQLNNEWHDQSETQSDYDSKSFDILLDYIYLRTDRLTLERIKGAADIAQYFELTDLEAAVSRVVDTWDEKSKSKAIHDNSFMLIEKSRVDMSNFLEKVIDSRVSVPLEFDEDVDYEDIEPLNYLTNNLKSQLFISDCIPDIILSIVDISSESIVYYPCHKSMLIRSEYFETMFNSEIFAGQNKVPIKEYDGFDILDRTIFKASELPVISVTCTDSRVAELVLSYLYHDNVDYIPLSLTVDLLYLSDELLVERLKSLCAVNITSKFKDFSFGEMTELKETTGYDVFELVRISWATRCDKLEHFTSKLIATNLETIFHNPELSSKLHDLIEESAGRIEHRQATDTIELVDDIRYYLSKKYGVSTALLEDFVPIGPSFTGVFAEDTKLRKDSLLMYSRDLEMIDTMLETLDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B317</accession>
    <name>G3B317_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_134637</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686372.1">
        <property type="nucleotide sequence ID" value="XM_006686309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B317"/>
    <dbReference type="GeneID" id="18249805"/>
    <dbReference type="KEGG" id="cten:18249805"/>
    <dbReference type="eggNOG" id="KOG4503">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031411_0_0_1"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="2">
        <location>
            <begin position="262"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV64058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="413" mass="46680" checksum="07AD3A3975C2221D" modified="2011-11-16" version="1">MDIDGSLSALSISEFQTAVDIDTSISSDAMEVDSISDLHNDVSSIETIREHDLNTSTPIKRMDIEVDAENSSFVSALSSALLSPTTVGAKYAMKLLPAPESTANEDDEIDTTTVRTLVTRHINSFSSNSDNSVFLDREPEFVYNPSKQDYDEEDIYSNSMNQSYLYRRYNRMSPTPTPIMPTTVPRDEDLSRYSNMSTPTSIQVHHHHYYCSPNKSVDTTQNDTSYMSVNSFSHSVNMLEDVKLPSPWKQESIPKEKYPYIISTYLQLSINFGVSIYGIYLIYNIIRTIRKDIDVKILQQSVQLALEIEECTKKYHDNNCSPDLIVPALEKHCSYWLSCMNQNSHPNFSGNKSSISAETLGLILNSLIEPLGFKFFVILFSFLVMVFALNFIFGFIRAKTYYGEQPTPDSAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B397</accession>
    <name>G3B397_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114144</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B397"/>
    <dbReference type="STRING" id="590646.G3B397"/>
    <dbReference type="GeneID" id="18247286"/>
    <dbReference type="KEGG" id="cten:18247286"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV64116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="414" mass="46558" checksum="BBCDB6A7679D0411" modified="2011-11-16" version="1">MTEQSSWPPKEATNKRRNSYIKFDSPCNYTVSKKALGEGSYSTVFECKNIKTSRHYAAKRYTKKLVYGIEDMLQNEFSVLKAISQSHKNLLSLVDYFETEQFFFLVTDLAKGGELFDRIITGANERLAEFEAVKVTKQLVDTIEFLHSKNIIHRDIKAENILFQTKTSTNILLADFGSARVLSSSEKLYNRCGTLSYMAPQTLNKSGYSFEADMWAVGVLVYFMLCGYMPFDCETDEETMEAITKGDYMFEPTSYWNHISSAAKDFIRQCFQLDPDKRMTAEEANTHPFVSPLTSKSSYSSYLNLNSLASNTPSSIFTSSASNLSLANKLKESLQNLQNIQRDPRASYTLSRTSSDFGDEKLKGAMCESPNIISKFSTPVASTAVSRAASVEQITSSVPKLSVDQKHAPTTFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3C3</accession>
    <name>G3B3C3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114157</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3C3"/>
    <dbReference type="STRING" id="590646.G3B3C3"/>
    <dbReference type="GeneID" id="18247293"/>
    <dbReference type="KEGG" id="cten:18247293"/>
    <dbReference type="eggNOG" id="KOG3996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048602_0_1_1"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="273" mass="30584" checksum="86F7C61C9083CFCC" modified="2011-11-16" version="1">MGLFWADKYPSPATSPAGNTSSGLAKCPIDHSAFSAGQTCPVRPKDSTSSADELSSSILNPMNNMPIDISTDMAPGQKIHLSTERTISSIPRGETASEGLWEYPSPQQMLNAMLRKGKGQGIDETAVESMVEIHNFLNEGAWQQILEWEDIHTKQTKIEPRLLKFTGRPHDLSPRASTYLWLSKFFPNTFNSNPPFDRHDWTVLRATGESPPNDWRKVRYVIDYYSAPDDEETGMPSFVLDTRPALDSPVDAYDRFVRLASPLWKQAMGDFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3L4</accession>
    <name>G3B3L4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114245</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3L4"/>
    <dbReference type="eggNOG" id="ENOG502S680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1726742_0_0_1"/>
    <dbReference type="OrthoDB" id="4086633at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="165" mass="18890" checksum="39E7749381586C88" modified="2011-11-16" version="1">MSSHGSMPAPASAPSSISHPSGYTGFAYPGLTSMVNANSDMVMPKVEAQFVDRTTCTVCGKRITRDMGRHMRTHHPDPRFKCIFPREECDHKSQRFNRPYDFKKHLMNKHFHFDNSSVKKSHNLSNKLNQWGNCACGKRFLSNEWLDHHILTKDASELCSLLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3T3</accession>
    <name>G3B3T3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dak1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_97792</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686040.1">
        <property type="nucleotide sequence ID" value="XM_006685977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3T3"/>
    <dbReference type="STRING" id="590646.G3B3T3"/>
    <dbReference type="GeneID" id="18250712"/>
    <dbReference type="KEGG" id="cten:18250712"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_6_0_1"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF1">
        <property type="entry name" value="YALI0F01606P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="12">
        <location>
            <begin position="9"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="11">
        <location>
            <begin position="392"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="596" mass="65239" checksum="53467A95F645F724" modified="2011-11-16" version="1">MTKHFVPENPNNLVKDCLQGYIVCNEHLSVLYHEKVIFNNKFDSSQVCLISGGGSGHEPGWAGLVGNGMLAACAQGEVFASPNFKNIQAAEKTVHSQKGCILVITNYTGDNLYFGMAQQELLARYGPGHVKLLRCTDDAAIPRSTNSLVGRRTLAGVGIVIKMMGAATQLPHLSLDDIYHFGETVNRNVISINAGLDHVHIPGHAPDSDYGKLQPNEIEIGLGIHNEPGFVKLSSIPTNEALISDMLQYMLSQDDPERSYLKYDSSDQFILLFNNLGGLPVIEEKALLFQTVTQLDRDYGIVPHRVLAGNFVTSLNASIFTITLFNVTKTAGMFTEQQLFDLFDQPTNATNWPNYVDHTASTGNYKDRIIKSFAHYDEFVPDTTNDVQIDPQTLYNILHTGSRNLIRMEPLITEWDTKMGDGDCGKMLEIAANGVLLGLDQGEGMATNGSILTCLNRILAILSNDMGGTLGAILYIFMKSFINNLTINLGSSQTDIRLIFATSLSSAIETLKGFTKAREGHRTVMDVLIPFVRVFGDTLDIYKAVDAAEAAAEGTRKLAPKLGRATYVGGLENKKDFVPDPGAYGVYEAIRGLRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B426</accession>
    <name>G3B426_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113802</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B426"/>
    <dbReference type="GeneID" id="18247124"/>
    <dbReference type="KEGG" id="cten:18247124"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="46"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="552" mass="61454" checksum="04C1B0A1307EDE54" modified="2011-11-16" version="1">MFKSKKPPLEANTLFDKDTRSESLHSSSNSFPPVGDHIKRKLQLRHVQLIAIGGSIGTGLFLQIGIDLTTSGPLGLLLSFAFWTVIILMLTVSVGEMVSFLPVASPFVTLAGRCVDEAFECCVGFNFFIMQALYIPFEIVAVNNFVHYWRDDYSAAITLCVQIVLYAAINVFAVKLYGEVEFWLSLGKLVLCIGLLLFTLVSMCGGNPQHDAFGFRNWHAVGGPIAEYRSTGSLGRFEGFLSGLIGALFIVVGPEYMSMVAGEAVNPRKNMPTAFKTVLYRLALVYIGGALSVTILVAYNDPDYLKTTTESTSASSPYVVGMTNLGIKVLPDIVNAVVLTSAFSAGNSYTFCSSRALYGLAERGFVPRVFTKCTKKGVPIYCIAVSMLFSLLSLLQLGSSSAIALNYMVNLCTGAQLLNYGFMVIIYYKFYQAVKAQGLDRRAFAYRSWLQPYTILISGFFIWIMIFVKGYTCFKPFSVDNFLFNYVMIFVSIIVYVFWKVFKRTKMVKPEEADLVTGIDEIEEHEYEYYAQVESESGKDVTLVRRLFSWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B463</accession>
    <name>G3B463_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_113827</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B463"/>
    <dbReference type="GeneID" id="18247135"/>
    <dbReference type="KEGG" id="cten:18247135"/>
    <dbReference type="eggNOG" id="ENOG502T53Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903480_0_0_1"/>
    <dbReference type="OrthoDB" id="4018007at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34249" checksum="F521C23145C26365" modified="2011-11-16" version="1" fragment="single">MEALKHYESSSEEELEPHHHTTPADTDPRQILPSLSLYSQNYSVNQHNMKGLYINIPWKPTFSTTKQLKVLSQGALKYLELNHYDFYQRYDWNIVGDNRAPLSSKDPSNNLHITLVSDIHGRPDQLSKFVDYFTNGIRKMAISPSLLKEESVNNDRLQALNKILKKSPSNVPQEKAVKLKFKPELHLFGSSTSSAVFVAGIIDDDPDTSNFFGGINLIAKDICDLLEISVPKEVFSTTYHVSLVKSSEPVLVGTSDPRSELSSITESLVHNFDSSVLQMVPIEVNTIEVDEIDTKKVTYSIRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B486</accession>
    <name>G3B486_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mif2/CENP-C cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_93430</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B486"/>
    <dbReference type="STRING" id="590646.G3B486"/>
    <dbReference type="eggNOG" id="ENOG502S47H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527842_0_0_1"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="6">
        <location>
            <begin position="384"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV63921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="473" mass="52730" checksum="96818DA035ED0C46" modified="2011-11-16" version="1">MDLLSLGSQSRKTGIKPRSNMRKDRYNMEDIDDFFEDESGSDEGGSESDGKGHGNRYISSNKPQGRRSSQWTQTRASEDRDSIIARKINFTDDEADKFDLSPIGNIHRRKSYSLKSPLSEQGSPPGEQYSLEQQDNMLEPEMSYDDLNNNILDELDEGVDFELARVPEETEVSSKSISSLTKNMALGRTTNSKRIRKRTPVVTPAPVVVSIRPSPLPSPPPDGLRRSRRTKIQPLAFWRNERVIYSKSYDDEADPDITLVRDTHNIPLQEIKEIIHVPAPTTSFARGKTSKSTSRRNKTKKSSSVSDSPSNSAKQAPTELDYDYESDPGISGSEWFEDNSLSLPVYESNDSESTKTQPVAFTHNFSKWLEDPPESSGSSIDNYKLATVFKDNSPVAGALFEFPVEGFKSSKNSGNCIYVFHVIKGLLEVNLSNHTFVVTRGCTFQVPRGNTYGIINIGNGNAKVLCVQSMVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4J3</accession>
    <name>G3B4J3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_113991</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4J3"/>
    <dbReference type="STRING" id="590646.G3B4J3"/>
    <dbReference type="GeneID" id="18247207"/>
    <dbReference type="KEGG" id="cten:18247207"/>
    <dbReference type="eggNOG" id="KOG2647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029048_0_0_1"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442769" description="GPI mannosyltransferase 2" evidence="13">
        <location>
            <begin position="22"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="393" mass="45439" checksum="19D3F42B344E9536" modified="2011-11-16" version="1">MWKTFLALKLAQLVVLYNVPAQFDVSSDILIESYSSDRLGLPIIDRLLDGFLIWDNVYFTDLFKNDIKYEHQFVFSPGWVALIRYIASLLPTQNFYVLLAIATVVSNVCQLMACQVLYVFSRKMFEKMPFFGLKSKDLAHKAALYYILSPGGIFLTASYSENLGSLLSILALYLREVSISYSANYHLKVRLWAVYIFSGIVLAAAFQVRANCLLLGIFYLYDLERFWRASEVSSTIISFVSGIPLFVSFVYTNYVGYKTFCPGRGEWCNHVFPSLFQYCQVHYWNNGFLNYWTPNNIPNFIISSPIVATNVYLIWYFYTKYPSHLLIPYLLLNAILVVLGVLFWNIQILNRILNFNPVFYWFLAVIDNKMIRRGLLFWILIQAGLFGAFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4K8</accession>
    <name>G3B4K8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_105024</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4K8"/>
    <dbReference type="STRING" id="590646.G3B4K8"/>
    <dbReference type="GeneID" id="18245772"/>
    <dbReference type="KEGG" id="cten:18245772"/>
    <dbReference type="eggNOG" id="ENOG502RXZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070609_0_0_1"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38607" checksum="5CC0CC7A810F1DF8" modified="2011-11-16" version="1">MSSSGKWNWRGSRAREGSRRGTNRDLERTSSSHSVVDSADTLVADDKEQQKLNQRAARFSKPDPTMGRGRSEYGFVSRGEDNRLQKSRVEREAYLATIIEKFVSYCESSSTLSLSKQLREFVDQEPSTPQKDPKLETSVTIDSILLSLRKLREALLNSKPDAFSVKVFLFSVRISASIGYYQTYVPSINYLLGQDTIKLLSPNEVEESASLLVLHLSHFNNHHTRAVETYMRYFKKNEQPELLKVIMSYYSKSYFTWCKLYNSETDNARSKIMRFGLTAMVEATIAAIQKSYFTLDKRFLNEEVLPNGVGVDALIDSEQVSWRVDGTNVIIKERAQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5F1</accession>
    <name>G3B5F1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MDR transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_98368</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5F1"/>
    <dbReference type="STRING" id="590646.G3B5F1"/>
    <dbReference type="GeneID" id="18250767"/>
    <dbReference type="KEGG" id="cten:18250767"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="38"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="594" mass="64094" checksum="F25C52BA8F8F1478" modified="2011-11-16" version="1">MPELEKTNSKDGKFYESNAGDGTLVSDQYLTGFKLSLTLLSVVLALFASALDQTIVSTILSTVGDEFGDFNKVGWLTSGYMLPMACLALSWGKISIAFGRKKTMLFGLFFFFIGSLIAALSKSMDMLIGARVIQGLGGSAIQAMTMVILSEVVPASKRSLSMTLIGITFSVASALGPFIGGSFTTHVTWRWCFWINLPISGIGFVFLMISFKPPKPEGDLKTKLAKIDFLGNFLMASGLVLVLLGLTFGGNDFAWKSAAVISCFILGGLLVIAFCVYNFKYSKIPIIMKEAATSPYVMTACFCGCFAFIQFMISIVYFSIYFQVVQGANAWQSGIDMLPMIITVPIVSISNGIFLRITRQIKLVLVFCGVCFVIGSGVSLLLRRGTTFGQHFGILVINGIASGLSFQSSLLSTQLAAPNTIPGSMIIVTALNNFFKSLGGVIGVVVGQLILQTSATSKMKDILNNLQRHSADYTILSNVGVDAIVANPSIVDQFPTSLKNSLIDAYVDSLHNIFYLSLASSCILLITSVFTSNKKLPKDGDIHTKNEPGDAKSTPNNDTNELENGQPKNNQKSDHDSENEEKSTPIDNSESNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5K1</accession>
    <name>G3B5K1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_130744</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5K1"/>
    <dbReference type="STRING" id="590646.G3B5K1"/>
    <dbReference type="GeneID" id="18249475"/>
    <dbReference type="KEGG" id="cten:18249475"/>
    <dbReference type="eggNOG" id="ENOG502S6UN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="134" mass="14805" checksum="E56E74210DF518DF" modified="2011-11-16" version="1">MFRQLTRTTIAKSRSVTRFYSSKFAPEQMPSPPKLPKEQQDEFERLQRIAGSQAAIDDYNRKISANGTVASGDAVAAGAPPELKTDIGGFSTSYLKTIPEFEGDVNPKTGERGGPKQDPLKFNDWSFNGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5Q9</accession>
    <name>G3B5Q9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_106747</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5Q9"/>
    <dbReference type="STRING" id="590646.G3B5Q9"/>
    <dbReference type="GeneID" id="18245914"/>
    <dbReference type="KEGG" id="cten:18245914"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_2_1"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="251"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="579"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV63284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="817" mass="92730" checksum="4AF4D3A964AA9C84" modified="2011-11-16" version="1">MKVKLTGNRKPLSEFTTPLGSGAGVPKNRRPKPVKDSAERLAKPFKVPFKIASNEDGSRYNQPQRSARNKKHNYALDLENPDDIPVNEDGHVIPAKKIGALNPRQLVSLNSETRLRAEFAVPLKDKSKIVNLPPPPLGTKPKVILPPRALHDPLSEFAIVLYDPTVDVIPGEEEKTEEPKQESDDNKENKEPATKKRKVHKSLAEILGISKYKDDASKHPNVPVVIDPRLAKILRPHQVEGVKFLYRCTSGLIDPKAKGCIMADEMGLGKTLQCIALMWTLLKQSPRGRKTISKCIIVCPSSLVRNWANEIIKWLGEGVLTPLAIDGKSVKNSEIGDSLKQWSVASGRNVVRPVLIISYETLRRHVDKLSGTEVGLMLADEGHRLKNGDSLTFNALNELRCERRVILSGTPIQNDLSEYFSLLNFSNPNYLGTRNDFRRNYENDILRGRDADASDKERESGDKKLNELTTLVSRFIIRRTNDILSKYLPIKYEHVIFVNLSPLQTKLYNFFITSPEIKKLLKGHGSQPLKAIGLLKKLCNHPNLLNLPEDLDGCQELMPDDYDYKKREVQTWLSGKFSILERFLYKLHHETGDKIVLISNYTQTLDLIERMCRVKRYGNLRLDGTMNINKRQKLVDRFNDPDGKEFIFLLSSKAGGCGINLIGANRLVLIDPDWNPAADQQALARVWRDGQKKDCFIYRFISTGTIEEKIFQRQSMKLSLSSCVVDEKVDVERLFSADNLKQLFQFESNTVCDTHDTYGCKRCQDGVQLTNAPAMLYGDATTWNHLNHEKLKENHDDLLQNESQFDDISYVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3B638</accession>
    <name>G3B638_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_114680</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B638"/>
    <dbReference type="SMR" id="G3B638"/>
    <dbReference type="STRING" id="590646.G3B638"/>
    <dbReference type="GeneID" id="18247533"/>
    <dbReference type="KEGG" id="cten:18247533"/>
    <dbReference type="eggNOG" id="KOG1748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_0_0_1"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="53"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV63371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="133" mass="15007" checksum="DDD789EA2B5C41ED" modified="2011-11-16" version="1">MFRSLIKAQLPRVSSGRRAISPAIFNPVLSNSLQFQKPQGVRFYSGFPELTREIARERIIELLEGYEKIADSGKELKEEASFIQDLGLDSLDVVEVVMELEHEFNIQIPDHEADSLKTVGQTIDYILAQPDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B645</accession>
    <name>G3B645_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_114692</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with CHS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B645"/>
    <dbReference type="STRING" id="590646.G3B645"/>
    <dbReference type="eggNOG" id="ENOG502QRVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="309" mass="34525" checksum="5CAC045F0DE96CE2" modified="2011-11-16" version="1">MTFGSFEELCKHTSLPLCSVISTSNSTSEFTRGVLPQCYSRSVELANTMIFSVGNAFIHFATLGVLLIILFNVRAKYTAIGRTEMLFFFYLFIGLTVSSLVVDCGVTPPSSSSYAYFVAVQMGLAGSCCISLLYNGLLCFQFWEDGSRRSMWILRLVSIGWFIVNFFIAIFTFKNWGTGLSTTNTTGLFVVGYVLNAFILFVYVVSQVALVLFALDSYWPLGAICLGVFFFVAGQVLMYVFSEKICEGATHYIDGVFFATVCNTFTVMMIYKFWDMITTDDLEFSVATVENGVRSFGLEDEKRNSTFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6D6</accession>
    <name>G3B6D6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ARF/SAR superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_130896</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6D6"/>
    <dbReference type="STRING" id="590646.G3B6D6"/>
    <dbReference type="eggNOG" id="KOG0072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000510">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20709" checksum="7E49E635786FC765" modified="2011-11-16" version="1">MGQTFSFANIFGKVWGTQKEIRILILGLDGAGKTTILYRLQMGEVVTTKPTIGFNVETLKYKNLTLNIWDLGGQTSIRPYWRCYYNNTAAVIFVVDSTDKDRIDIASKELHLMLKEEELLDSALLVFANKQDQPGAMTAAEVSQALNLTELKDRSWSIVASSALKGEGLTEGLDWLMDVIKEEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6G7</accession>
    <name>G3B6G7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_114779</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6G7"/>
    <dbReference type="STRING" id="590646.G3B6G7"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025793_1_0_1"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="206"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV63462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="559" mass="63481" checksum="4BD75FDA6723B74C" modified="2011-11-16" version="1">MVDHTVPLGRTNSLPPDHPLLPDRSPSQDHTRPSHHSTPPQLFIQVPQNSRFQIPQSHFQDSPPVPDLSTTLGTLKEAPQFTSPQFTSPTVSDASFESISQVPTPIINNGSFGALSPVDSGLEYPKTRRTTSTKPQKPPRIVSEYKPIDRADFVPQPHRVSSVPGPSEKTLGHSLRTLSEESRQEEDVERFWKHQMFFSAKFDAWFKFVKIIGSGSFSLVVLVHDVDDDRRQAAIKIISIPMNNKAQIKNFKYFLRRELSILHQLHHKNVIRLLDYNISLDLDLRGWDEGPGDESDQDHQDMARELSNSSSIKDLASLQQNNHQLLFLNYCPGGNLYEFSVRTFKTWNQDVRYWRAVVQIVRELVVAVDYIHTNNIVHRDIKLENVLLNYTLDELMEEPHLEGITCLTDFGLAKKLSSSSQMLSTRCGSQDYVAPEILMGLKYNGVLTDSWAVGVVIYCLVENRLPFDLPSYDDMAQTGISPSVIKRRMAKNSPAHRIAMIDWDWYTASDLVANASDEMSSLIRGLQSAVDVLLVRKERRKSVSEMLVSPGFEWVRRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6S3</accession>
    <name>G3B6S3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114314</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686797.1">
        <property type="nucleotide sequence ID" value="XM_006686734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6S3"/>
    <dbReference type="GeneID" id="18247370"/>
    <dbReference type="KEGG" id="cten:18247370"/>
    <dbReference type="HOGENOM" id="CLU_1834908_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="140" mass="16081" checksum="63624FAA29A7B32B" modified="2011-11-16" version="1">MESINDKTLTDTPIRRGEGEKEYGEMARSGQASGVKNEGSRSSGSRDTCDSEEEDISIKAFIKSPSRKERNADERRRRITKYNTTILKESREERRKRREERLSQFDDDELEMNEINSSDVGSVDSDSPRKKKRVSFVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6W3</accession>
    <name>G3B6W3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114340</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6W3"/>
    <dbReference type="HOGENOM" id="CLU_2903990_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="62" mass="6928" checksum="737293EC460F3DC5" modified="2011-11-16" version="1">MKHISAKHSQPHSCTFHASTRIATDNRCPGYSESHKYPDPPPFAQTHRYHSSGILSVPTTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3B743</accession>
    <name>G3B743_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114404</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B743"/>
    <dbReference type="HOGENOM" id="CLU_2527224_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442798" description="Secreted protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9100" checksum="ED300ED5E868991A" modified="2011-11-16" version="1">MLIDVIRILIVGAVIAAFVVNAQRQQTVNGSTPIPTEAVPAYTPHRKQQYSGSLPDTSKPTKGKPRICSVYSNSIPLTSRHISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B780</accession>
    <name>G3B780_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_94476</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B780"/>
    <dbReference type="STRING" id="590646.G3B780"/>
    <dbReference type="GeneID" id="18250402"/>
    <dbReference type="KEGG" id="cten:18250402"/>
    <dbReference type="eggNOG" id="KOG0755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_3_1"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="122"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="231"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="324" mass="35070" checksum="E82F996D9BC58F5E" modified="2011-11-16" version="1">MSKHKETPQVSTAGGFVAGALAACGAVTFTNPIELIKTRMQLQGELTKVDKNAVKIYKNPFQAFGVIYKNEGLRGLQKGLVAGYFYQIGLNGCRFGFYEPARYNLTKLFNPTALKEGEKAPQSLGINVAAGFISGTAGATIANPLFLVKTRMQSYSAVKNASGQSVAVGQQTFYRSPFEGLKKIFKAEGIKGLFRGVDAAILRTGAGSSTQLPSYFYAKSLVIDNHIVAEDSILVHLIASSVAGLAVAVMMNPWDVVLTRVYNQKGDLYSGVGDCIVKTVKTEGITAFYKGFWAQLFRIGPHSILSLMFMEQSVKLVAQLESYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B788</accession>
    <name>G3B788_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_108727</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B788"/>
    <dbReference type="STRING" id="590646.G3B788"/>
    <dbReference type="GeneID" id="18246057"/>
    <dbReference type="KEGG" id="cten:18246057"/>
    <dbReference type="eggNOG" id="KOG0979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004969_2_0_1"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="49"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="209"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="707"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="798"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="887"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV61594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1093" mass="125336" checksum="52D9DAAA81D9C403" modified="2011-11-16" version="1">MVVIPQHSHRPSFDEPSPGQTLDGVLRSVSNGTHKRHKPNSPPFKPGNIMKVTVTNFTTYSYAEFSLSPTLNMIIGPNGTGKSTLVSAICLGLGGKPELIKRPSLKDMIKSGENRAEVTITMMGNGGRSFVIERSFDAKSSEWKVDNKKVAERFVQTKVKELNIQLDNLCHFLPQERVAEFAGLSPEKLLLETQRTLKNGDLHVMHESLIALEKDRDAAAEDLKNIVDNVDKLTSEREILQEEVERLNQFNDKATDLKYHELLLPYAISNDDKEKKRMLKKQRDDAKAKLNAFDNNADPLHKEVTLCLRKVDDLKAQIFELRSEIDQSKEQYKRESSTVQKITSSIQEMKEELQRTKIGKETIRKELELLNSDVQDLRTKYNELGELDALTEERDEFYKLRRDKNSTVTETMGRLEAIRDNIESQEREVSRLGFKIKEQEAVLNTKDKLSMLNPSSNGSNNPLLSNAYHIHQELRKRPELKQYYFESPVVTCDVTEKSVAPVIEKIINPSTLMSLTFTSEDAYNKIPNILFKNFNSPTRIIVEQASEPQIAKSQISGFGFQCYLSDFLVGPSEVINMINSNSKLNWIPYAPELSQDQVARLLNPDSNGRIPFMRFAVGNQLITVHKSKYGAKQFVSVTETVTRSKFFGKENVVPGEVKKQTQLAIESLKSQQVIAQDAKMNHEAEKEQLLPLVQQNKNAFADIDKQYREVKEQIQRKSRIKEKIERTDDLIKRKTRELSSSESSKLNKYRKRILNLNVELATGSASKQAAAVDITSKSVELNNLVLERFQHETRASSIKALVEEIDQYKEELVKLYEEANANYRNIRESDASKKIKEQKKHYTEKEERDLAKLAEKYLETNSLNQIYVKNKIQLIRDELSVLTAAADRNCINRLKEVEAKLEEYENTLPRYEKAKLDLDARIEKIQSEWEPELTKLVFRISLSFKKKFVAVASDGEVRLKKQEKFKDWRLEILVKFRQESELKILDRQSQSGGERAVSTIFFVMALQGLTQAPVRIVDEINQGMDPTNEKQAHKFLVHTASKASDSQYFLVTPKLLTGLYYHPSMKIHCIFTGPLIDPFRKNDVDFMDFTDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7S5</accession>
    <name>G3B7S5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_115774</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7S5"/>
    <dbReference type="STRING" id="590646.G3B7S5"/>
    <dbReference type="GeneID" id="18248007"/>
    <dbReference type="KEGG" id="cten:18248007"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_1_1"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000017">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000009">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="151"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="7"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV62849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="345" mass="36823" checksum="542C8649D4858CBC" modified="2011-11-16" version="1">MKVTVCGAAGGIGQPLSLLLKLNPHVDELALFDIVNVHGVAADLNHINTPAKVTGHQPKDKADQSAVRAALERSDLVVIPAGVPRKPGMTRADLFNINASIIRDLVKNIGLTCPDASILIISNPVNSTVPIAAEVLKKLGVFNPSKLFGVTTLDSVRAETFLGDLVGEPAPEVKGRISVIGGHSGDTIIPLVNITTSISQKVQKISTSDYDNFINRVQFGGDEVVKAKNGAGSATLSMAYAGYRFAENILQSYFSSTFNSYYINDSAYIYLPGFEKGEKLSKKYLDGIDYFAVPVALRNGAVESLVNPFEEFTISDAEKQLISKALPGLKKSIEQGAAFVTGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3B821</accession>
    <name>G3B821_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NCA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_136262</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B821"/>
    <dbReference type="STRING" id="590646.G3B821"/>
    <dbReference type="GeneID" id="18249956"/>
    <dbReference type="KEGG" id="cten:18249956"/>
    <dbReference type="eggNOG" id="ENOG502QTT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658883_0_0_1"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="417" mass="47696" checksum="575C6563991C52F3" modified="2011-11-16" version="1">MDLFNSRSLFRQIHQNNLIANSVADSNNDFSTISNVLIHQTLVLRENLKYWSAVKHSLIYKLYYGLQTLPKRAYAFFLQVRADDWKVQHVPNIVKAVEDDINCNISTIKRQLSDTYKKLGHIVAHKDKLGELNPDDYRLAAVQSLEPGFWTRYWIPLVLAVLIGPTLSFKVVRNRSRILDWLNNNVRDVAVGFYDNWLIKPVGDVINIIKQDSNIIAAKESLNSSVSSLERMVRDYITDNHIPVQEVDLKHQLELGDLTLIMSKYEKEMKSPVRNLVNGTLIRSLLIQIQKTKVDGDLVINGIDKLMKSQQLLLGIVSISPSIFIVYQLAKYLSRPNFIINGKDLKKSCLGNLVGLQLDDDDESRGVLLVNTINLKIESRLFLSKSVFTMLEEDLNRLLAGEDTLMKLYVVYSGYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3B827</accession>
    <name>G3B827_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115799</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B827"/>
    <dbReference type="STRING" id="590646.G3B827"/>
    <dbReference type="GeneID" id="18248024"/>
    <dbReference type="KEGG" id="cten:18248024"/>
    <dbReference type="eggNOG" id="KOG1255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_1_0_1"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="323" mass="33778" checksum="3444F6F3E2BF058D" modified="2011-11-16" version="1">MFNKQFTRGIASSQPARNYASTIKNLKINSDTKVIYQGFTGKQATFHAEQAIAYGTKVVGGTNPKKAGTTHLDKPVFASVKDAIKQTGADATGIFVPPSIAAKAIEEAIEAEISLAVAITEGIPQHDMVRIAQILKTQEKTRLVGPNCPGIIAPEQCKIGIMPSSIHKRGKVGIISKSGTLTYEAVAQTTTVGLGQSLVIGMGGDPFPGTNYIDVLTLFLNDPETEGIILIGEIGGTAEEEASEFLKQYNLTRDVPKPVVSFIAGVSAPPGRRMGHAGAIVAGGKGDAKSKIAALESAGVVVEKSPARLGNSLLAEFKAKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B856</accession>
    <name>G3B856_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115816</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B856"/>
    <dbReference type="STRING" id="590646.G3B856"/>
    <dbReference type="GeneID" id="18248034"/>
    <dbReference type="KEGG" id="cten:18248034"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_0_0_1"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="83"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="190" mass="20897" checksum="7B363BF6C8CC5F26" modified="2011-11-16" version="1">MAIKRALAIPLACRPAASMLSPVLYQPIKLQGLMAIRGLSSTQTIFVGRATTGTARRFYSVISEECKAKLYNYPQIKKLTQAPNPDSIIVDVREPVEYEEGHIPGAINIPFKSSPGALGLNAEEFEENFGFKKPDADKELIFYCLAGIRSTAAEDLAKTFGYKKRGNYVGSYEDWVANEIKKDTVPATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8N1</accession>
    <name>G3B8N1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115219</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8N1"/>
    <dbReference type="STRING" id="590646.G3B8N1"/>
    <dbReference type="HOGENOM" id="CLU_1669159_0_0_1"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="158" mass="18162" checksum="1116338CE97E53D2" modified="2011-11-16" version="1">MALAMSSLEDEEEADPEIYTQFEKYFDTKKPGSKNTDPSTEPLKSNNNDYLYAVYQSEGIRPFEADCRGKSIRKYMKEHTGWSDNLIEDWGKMLTLSNEKHGIPADIKTNNDKSKSKPQDKNAKKANYHYNDKNKAQKANHNRKSQHNKKSKLETAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8Z2</accession>
    <name>G3B8Z2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_115252</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687980.1">
        <property type="nucleotide sequence ID" value="XM_006687917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8Z2"/>
    <dbReference type="GeneID" id="18247794"/>
    <dbReference type="KEGG" id="cten:18247794"/>
    <dbReference type="eggNOG" id="ENOG502RKY8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181695_0_0_1"/>
    <dbReference type="OrthoDB" id="4083952at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="62" mass="7046" checksum="7A973B19B7042E0D" modified="2011-11-16" version="1">MSQQLPFRVRATDIIHRSTVLGLVGICVVGLGSISFNIYMNSDYAKMNRNKLKFDPEQTKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9B8</accession>
    <name>G3B9B8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_115310</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573</strain>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9B8"/>
    <dbReference type="STRING" id="590646.G3B9B8"/>
    <dbReference type="GeneID" id="18247816"/>
    <dbReference type="KEGG" id="cten:18247816"/>
    <dbReference type="eggNOG" id="KOG0225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_2_1"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="62"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV62686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="396" mass="43424" checksum="7D6F32D86A39C071" modified="2011-11-16" version="1">MFNTRASRSLVGSVGMAKRTLASASTSVSIELPASSFEGYNLEVPELSFDTEKENLLQMYKDMVSIRRMEMAADALYKAKKIRGFCHLSVGQEAIAVGIEHAITPQDTVITSYRCHGFAFLRGASVREVLGELMGKRSGVSYGKGGSMHMFAPGFYGGNGIVGAQVPLGAGLAFAHQYKGEPNATFALYGDGASNQGQVFEAYNMAKLWNLPCVFSCENNKYGMGTAAARSSAMTEYYKRGQYIPGLKVNGMDVLACYQASKFAKDWCASGNGPLVLEYETYRYGGHSMSDPGTTYRTREEVQHMRSRNDPIAGLKLTLLEKGIASEEEIKDYDKAARKYVDEQVAIAEADAPPEAKMDILFEDVYVKGSEIPELRGRISDDTWNFAKGTFSNKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9P4</accession>
    <name>G3B9P4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="6" type="ORF">CANTEDRAFT_115388</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9P4"/>
    <dbReference type="STRING" id="590646.G3B9P4"/>
    <dbReference type="GeneID" id="18247846"/>
    <dbReference type="KEGG" id="cten:18247846"/>
    <dbReference type="eggNOG" id="KOG3350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074410_1_0_1"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="253" mass="29371" checksum="C9F05D358EAA6C73" modified="2011-11-16" version="1">MEFDNDEPITLSAHALAALQEFKDEEKKRLEVFEQLYKKSEEDFDAKNESQPTNNQPVSIDSFSEDWQLSQFWYTDETSKILGKALLEGADEDTVVVIASAPAVYAAMMNFSKEELPTDKIYLLEYDTRFKLLAGDKFYQYDYNTPNAIPEILRHKCHRLLIDPPFLEEECQKKSAMAARKMLVKNHDLKTKNGDLQFKLISSTGERMKSIMEETYPECQTTSFLPEHKNGLSNEFRCYASFECSQWTFQDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9R4</accession>
    <name>G3B9R4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_125333</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9R4"/>
    <dbReference type="STRING" id="590646.G3B9R4"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_24_1_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9 13 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="102"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="553"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV61951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="676" mass="76218" checksum="A562DDDFAA7D0386" modified="2011-11-16" version="1">MSYSRTPSRSRSSLGNYPNSNSPAISSSTLAASQNQTPKTRVSVTDLRRPPSSRSNRPASPRMSFAGGPSSSLNRSRSSSSMGMRSRPTTPSFIKPDPYTGSISVSIRPNPYSVDYQNRSSWFIDEPSNTIINNEDTSEFTFDNVFRPDTSVTNRHVYNKACAPLVHKFLHEGYNSTVFAYGMTGSGKTFSMRGRDQDPGFVKLAIDEIFDRIENDVSSKKFTVSITYLEIYNEKIIDLLNSGPPISSDLKIRDDPVYGNKIIGITNPVIKSRDQILQYIKRGDNNRKTSETDYNARSSRSHAILQIKLNTVDLTSGMETNATLSLCDLAGSERGTSSSERRKEGSFINKSLLALSTVINKLSISSNTGNLTDHVPYRDSKLTRLLQPALSGSSLVSILCTIHMGSSGMSSKFVDNQFVAETYNTLRFAARAKDVVINVQKNKSTLIGEGDSARLVEELRRTVEIQSNEIFMLRNSDNPNAMQVDDQPSNHRTTELEIENKVLYEKLEHLTRLTDLQKTETVILKNDSLNDLLGSDLDNNSSQIMIANVEEFYKRVNHEIDEYRAYIRHLEQRLKSAYQETASNQEPKRFHGLSERQLDALLKEQEEEIMHLKEVVKDKDHFIKSLTKTSKLRRLVDSDFVNTPEKSKNSHIDKENNEVREYSIDRKNGESMNFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9T5</accession>
    <name>G3B9T5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="6">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_99074</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="6"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9T5"/>
    <dbReference type="STRING" id="590646.G3B9T5"/>
    <dbReference type="GeneID" id="18250821"/>
    <dbReference type="KEGG" id="cten:18250821"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="10">
        <location>
            <begin position="36"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="100"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="549"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="670" mass="74483" checksum="EFD632995DFB6356" modified="2011-11-16" version="1">MVESHVTLDHEKMQLPPDGFKERSTEKPNLASFEEYQTLYKESVEDPSSFFGKMGSKFLDWERPFDLARYPVSTENDFKHGDIPSWFINGKLNASYNTVDRWAFKNPNKPAIIYEGDEPDQGRIITYGELLKDVSKMAQCLTKLGVKKGDSVAVYLPMIPEAIVTLLAIVRIGAIHSVVFAGFSSSSLKDRILDANSKIVVTADESKRGGKTIETKKIVDDALKQCPDVTNVLVFKRTGNSHVPFFEGRDLWWHNEMDKYGPYFPPVPVDSEDPLFLLYTSGSTGKPKGVQHNTAGYLLGAMLTTKYVFDVHESDIVFTAGDVGWITGHSYVVYGPLLNGATTVVFEGTPAYPNYSRYWDIVDKYKVNIFYVAPTALRLLKRAGTKYIENYKLDSLRVLGSVGEPIAAEVWHWYNDNVGRGKAHIVDTYWQTESGSHLMCPLAGVTPTKPGSCSLPFFGIVPKILDPVNGHELNENDVEGVLAIKNAWPSITRGIFNDYSRYIDTYLKPYPNHYFSGDGAARDKDGFYWILGRVDDVVNVSGHRLSTAEIEAALIEHELVGESAVVGYADDLTGQAVAAYVSLKSTVKVDDVEAVKKELILTVRKEIGPFAAPKLILLVDDLPKTRSGKIMRRILRKVLAGEEDQLGDISTLSNPGVVEQIINVVKSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9T6</accession>
    <name>G3B9T6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OPA3-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115420</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688895.1">
        <property type="nucleotide sequence ID" value="XM_006688832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9T6"/>
    <dbReference type="GeneID" id="18247860"/>
    <dbReference type="KEGG" id="cten:18247860"/>
    <dbReference type="eggNOG" id="KOG3335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377952_0_0_1"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21936" checksum="02179BA7BE54C97F" modified="2011-11-16" version="1">MSGVITLKLTSLLIRTISKPVANAIKFQSRQSPFLKTNFVRFGQFINKIDMKLRNNSNVKVRPLNDNKAIELGSNFLSELFVFSIAAGLIIYESVKPKKSVSQPVEIPPKAEGATGSINKSTSKADPKPQEPQKSKVKDTKVDDETNSKWIGKVEELQTTVSTLAQEVSQLKSQNSTILEELKQLKPVNSTISHVNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9V9</accession>
    <name>G3B9V9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_99087</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9V9"/>
    <dbReference type="STRING" id="590646.G3B9V9"/>
    <dbReference type="GeneID" id="18250823"/>
    <dbReference type="KEGG" id="cten:18250823"/>
    <dbReference type="eggNOG" id="KOG2441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085411_0_0_1"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="144"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV61980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="319" mass="36783" checksum="AFA80D53BC6953C1" modified="2011-11-16" version="1">MFSSLLSRPKHSDYFQPIKLGSKKSNINTRVLVVPEKESQVQVVHNDNSNSHSTLSKFYLNKDGTLNYNMTIAAQASDHRFHSSYEDTIPLKKRFPNLKHSFPKQTLATCPDDSVQKCVEETELVIKQLISQQSGEDNKESTQYANVTSSDVLGEERGRERQIQIKNYQEDPMLPPKHKLRKNRHTEPSPPAPILKNTTGSEKLTKEEQAKWKIPAAVSNWKNSQGFTISLDKRMQASTSNETHSVNLSKLSELTSALDDAEKQAREDIKIRNELRKEMMAQQEKEKELKLKELAELTRNQNNKRRHYDYNDANKRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9X1</accession>
    <name>G3B9X1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_123876</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9X1"/>
    <dbReference type="STRING" id="590646.G3B9X1"/>
    <dbReference type="eggNOG" id="ENOG502QWTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017969_0_0_1"/>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="95"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="753" mass="86294" checksum="923E700597FDF27D" modified="2011-11-16" version="1">MSDSFWARHVEICTKINGKRYPVPSSVVNSLLKSFDQRNLPRPSTTQIQALMNSPSANGEASKAYTLIRYYQVSQQGLFVTNENTDKFGTTIKYTGAENWESVMCYMDALLFAMFANLDSFEPMLFLSNQSQNILVNRLSNLLRVYVNLLRTGNLIKTDLTIRICETLHQLGFTEAMSHKQQDASPLFEFLAETLSMPLLTFKIDIQHGGKFNEEDDRKYSKERMLFVSIPEVVSGESNNENEILLEECLEHYFNNSINVKRELERRATMESSKNHKPFTEMIETVEDPTELTHESGSISKGSSRIQVRTRSSTLSIWTVNDNEPNSKPKEVSLPAWMFLRLLPFYTDDNDVSVSENGKTDSIAKGSREFAKRRPVLPICLKRYSFENKRANRSQVKVIIPPVINLPSFVADENDDNKTSHNYKLILESAICHRGTSTTSGHFVAAVRRNYQRVNETDDESYCAEWYLYDDLHKPKVVEKSFKEIFNTEWPYILFYRLISYEESESSANSIRSGQSSTNSPRVIIPQGSKSKYWQEDTLSPILSASNSPSFKSESAIDSLNKSLTNMSANSEGGSDTAPPESKHVDIRDRYYWYIPDSNMDYYKEDSLSKVSTRRTSFTAPFRKNSQWSETSATNTKSETSAINTKSPTVDTKSQETPSPSGSMWRFKSKNKSKSPPLETHEIESMVSHMSLTNPEPHIETITDVHSNPERSKIDTRHHHHILHRHNHDEINNSYKRSRSMREAYRKEKCIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAF2</accession>
    <name>G3BAF2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_107995</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAF2"/>
    <dbReference type="STRING" id="590646.G3BAF2"/>
    <dbReference type="GeneID" id="18245995"/>
    <dbReference type="KEGG" id="cten:18245995"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV62046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="181" mass="20540" checksum="257CFE5635BC586F" modified="2011-11-16" version="1">MRPLTEEETKVVFEKLANYIGRNISFLVDNPTAPHVFRLQKDRVYYVSEQIANFATSVSRKQLMSLGVCFGKFTKTGKFKLHITSLSYLAQYAKYKVWIKPNGEMPFLYGNHILKAHIGRMSEDIPEHAGVVVFSMHDIPLGFGVSAKSTAETRNLVPTGIVAFRQSDIGEYLREEDTLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAG9</accession>
    <name>G3BAG9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115513</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAG9"/>
    <dbReference type="GeneID" id="18247900"/>
    <dbReference type="KEGG" id="cten:18247900"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016665_2_1_1"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="312"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="565" mass="64828" checksum="6BD1DAAD2E45C9FA" modified="2011-11-16" version="1">MSSGHHAGEKPGRIQSINADQEIVLKQVWAYIFRFFGYQLEIDDEDLAYKECFVSSTRCTQLTDSGFGGLNYGLVRTGTKDSTTSSHISHKTSASTYSTLNKKKKSGILKRGGNKKIEVQEVRAPATSKRMKYIQSNSSFEKYTGIAIDPKVAYVYNNFYKSTFENSEDYMSDNEDYGEVDDDDVSISSFFTAETYVDEPDMKAFVSAVASSMNKSASASYLVEEIKVKPNTSLVSGINKYDPKRLHPGVFGSLRNDAFDNYILRFVRARKFKTEDSMHMIFKALDWRTSEDYRPNEWENEGDAPSYLSGKNPGFIRNYTSQKSFVRGHDKERSPIFFFFAKKHLISESPLADTQRFAVCTIESCRLFLRDITDSVDTCSIVFDLTGFSLKNADYNAIKFLAEVFEAYYPECLGKVLIFNAPWIFSTVWNVIKNWLDPVVASKIHFAKDFKELNKFIDREWIPKSMGGDDDYDGEYPVPTERDGHFMKQRDGDFSRLMRKRDEVILKFLSTTKKWIEATDPEISDKYLQDKINLCGELAYTYIQLDPYLRYPGFYDRNGSLQVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAT0</accession>
    <name>G3BAT0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_125631</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAT0"/>
    <dbReference type="STRING" id="590646.G3BAT0"/>
    <dbReference type="GeneID" id="18249113"/>
    <dbReference type="KEGG" id="cten:18249113"/>
    <dbReference type="eggNOG" id="KOG0264">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020445_3_1_1"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="438" mass="49227" checksum="4D0DDEE2F771D398" modified="2011-11-16" version="1">MSTIIDAPLATDPDSGPLLDQQAHSNYRIWKKNTPFLYDYISTHALLWPSMTIQFFPDLDKPSDNQIPPTTQQSKDIDHNVVYQRLLLGTFTSNQAVDSISILQLPYYDNLNKHLNIDKLNYNPDKSEFEMTTVPKKKMSMLQKINHLGDVNKLVYMPQNPDVLVSGNDYGSLVIYDRTKHSSYKNTSDSEDINKPQLTLQSSNQGEGEQIFAVDWNKQKEGTIVSGKMNGSVNIHDIKSSFTSTDSTDIHPLRTYDCFFHGVNDVQWVPDHEAIFAFVDEGGAFKLVDTRTTGSTAIDRSITQGPANTLSFNPQNSAYTVIGDGSGNISVWDIRNIKHSGSEVLTIQKAHDEVITRVKWHPKFHSVFGSSSGDKTVKIFDVGQCEKNNGMVFVHSGHMLGVNDFDWSLHDDWMVGSVADDNSLHVWKPSYDIVKGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3BB46</accession>
    <name>G3BB46_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1892-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115607</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688967.1">
        <property type="nucleotide sequence ID" value="XM_006688904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BB46"/>
    <dbReference type="GeneID" id="18247932"/>
    <dbReference type="KEGG" id="cten:18247932"/>
    <dbReference type="eggNOG" id="ENOG502S3ZA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1864865_0_0_1"/>
    <dbReference type="OrthoDB" id="4035606at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.250">
        <property type="entry name" value="YML108W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015080">
        <property type="entry name" value="DUF1892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035946">
        <property type="entry name" value="YML108W-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08987">
        <property type="entry name" value="DUF1892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89975">
        <property type="entry name" value="Hypothetical protein Yml108w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV62796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="137" mass="15416" checksum="3B38D2F6FD7941B2" modified="2011-11-16" version="1">MGKKSKRNNGSSQVVDTQPIDIVVPDTPLTNENDHLEELDNPLRIITLINSPDVPEGDLQERLMDYVQTMDEVDGFFNEFDETVAVPNDGHIKYEVGSDGLVVIVIDSTELRDEVLKFIDGYNDRMIEGSHETTKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBB0</accession>
    <name>G3BBB0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_131089</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBB0"/>
    <dbReference type="STRING" id="590646.G3BBB0"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026724_0_0_1"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="504" mass="56105" checksum="AEB0503D494EA048" modified="2011-11-16" version="1">MSYNNENYNPPNYPTTNNYDYENNYDEKPESNQNFDEAFKVTKPRFNDWPFTIFFLLVVAGFIGVGGITLNALRETFDFQGTSIYNSGNKFSLNTNTIILFAFIIALSLVLSTLIIVYARMAPRVFIISGLILNVVLGLATAIYYFAVKYYSAAIVFLVFTCISAFCYWSARSRIPFSATVLTITIDVMKRYPSTLVTSFIGIIVSSSFSVLFSVVIVGCYVKFDPNSQNEGCSVGGGSCSQAKLIGILVFVFFAGYYISEVIRNIIHVVIAGVYGTWYYLAGSDRGAPRFPALGALKRALTYCFGSICFGSLIVSVIQLIRAGVQILKSDAFGSGNNCAGCAFLVLDFIIGFVEWAVKYFNQYAYCYVALYGKSYIKSAKDTFDLLRFKGMDALINDCFIGTSLNLYALFVGYVVALLSYLYLKYTAPEYNSSGTYYAPVVAFSFLISGQITRVALVVIESGVSTFFVALAKDPEVFQMTNRQRFDEIFQNYPQVLQKITSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBH6</accession>
    <name>G3BBH6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_115657</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688985.1">
        <property type="nucleotide sequence ID" value="XM_006688922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBH6"/>
    <dbReference type="GeneID" id="18247955"/>
    <dbReference type="KEGG" id="cten:18247955"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV62815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="571" mass="63604" checksum="F709E1F678D7D78F" modified="2011-11-16" version="1">MSSTSQTDSVPAGQHIFQSDEKLTTPSPVQYSDSNGSDDDQIYSYIGMQGKKLHLAVAIMCGVGFILFGYDQGVMGSLLTLGHFRETFPEIDTVTYGYSRSAFQGFAIGIYEIGCFASALSTIWLGDKYGRIKLVFAGCFIMMIGGALQACAFHISHLIVARVVTGLGNGFITSTVPVWQSEIAKPEQRGKLICIHGALIAGGIAISYWVDFAFYFTRNLHPHQAVSWRFPIAFQCIFPLVIMPFIFKFPESPRWLLRQGRVHEARKVFSALEGVPANSAIVNDEINEIEESIRMEKSTGADKFSFRRLFKQGPKRHFHRLCLAGWAQLIQQICGINLITYYAGTIFEQYIGLNALDSRILAACNGLEYFLAGLIPILFIEKWGRRPLLIAGSIGQCVCMVVLTVASYYSDDKWGGRRNGAPIVAAVFLFGFNTFFALAFLSEMWLLPPELTSLETRAPSAAISTCCNWLSNFVVVMITPVLFQSIGPFTYALFAGINFLIVPVLYIFYPETKGRSLEEMDLIFNKTPINKPWQVVRIAATMPYHHAGLHEEETELVSRVSSKTHVSHIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBK7</accession>
    <name>G3BBK7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTEDRAFT_115027</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBK7"/>
    <dbReference type="STRING" id="590646.G3BBK7"/>
    <dbReference type="eggNOG" id="KOG2487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040211_0_0_1"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EGV61560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="381" mass="41471" checksum="4B33272EC0D1B95D" modified="2011-11-16" version="1">MDEISDNTFIEVHGSDVSNDDPSLLTIVLEVSPEGWFNIKDQTSIMDVVKSLLVFLNGHLSLNNSNQVAFVLSSPAGSKFLYPDTSKTYEEIPLNVTSEETVENSNKSEELSFVTKGMYRQFRVVDETVLSGLSQTMSDITHAQDDKVTGSSRLSGALSLALSYTNRMMKLDQSISTTTASAISSAANISNKESSTAGASSGTNANSYGTSRMKSRILVVTPNDNEDIKYISLMKAIFGAQKMKVAIDIAKLGRKDSSYLQQAADATNGVYLHIEKPLGLIQVLCTAYFIEPSIRPLMILPTNSNVNYKASCFITGKSVEIGYVCSVCLCIMSEIPDRMSCPTCNSHFDEKLIAKLKRKPVVKKRKLDNGSSESSTPAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBR1</accession>
    <name>G3BBR1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_99263</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BBR1"/>
    <dbReference type="STRING" id="590646.G3BBR1"/>
    <dbReference type="GeneID" id="18250844"/>
    <dbReference type="KEGG" id="cten:18250844"/>
    <dbReference type="eggNOG" id="KOG3042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047148_1_0_1"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV62215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="306" mass="33642" checksum="2086DCB84A5374AD" modified="2011-11-16" version="1">MKSIQIFRTVAQVRQWRANALFAHQSVGLVPTMGALHDGHCSLISQSLQDNDKSIVSIFVNPSQFAPHEDLDAYPRTVDADMALLNQFPGKKVDAVFIPKVSEMYPSGISTNIDEQRGAFVAVKGCSEQLEGSSRPQFFRGVATVVTKLLNAVTPTRVYFGQKDAQQCVVVQNLVKDLLIETTVKVLPTKREANGLAMSSRNAYLSEETKQKSAVIYQSLVNGERFYQEKSQHGPVNVGEILARITDTLNDSTGFDIEYIALSHPETLEDLEVVEPGVGAVVSTAVRVPREGSSQQTRLIDNVILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BBT4</accession>
    <name>G3BBT4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_125882</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="GeneID" id="18249137"/>
    <dbReference type="KEGG" id="cten:18249137"/>
    <dbReference type="eggNOG" id="KOG1910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000740_0_0_1"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF15">
        <property type="entry name" value="PROTEIN FMP27, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1225"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1628"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1895"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2381"/>
            <end position="2453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1978"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2404"/>
            <end position="2418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2419"/>
            <end position="2453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV62234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="2582" mass="296245" checksum="918325646183CF6D" modified="2011-11-16" version="1">MFTLSSPQLVVYVLAAVLAWSLAWSVVYKLTGVYLGSIWFNNGVSFNNIHIHTKGAELKFESLRFRMWGNSKRLIISGMNLTLHQKHTPESTRPIKPHRPFSLSMFPSNFVGKFLVKAGLKVIPNFSIEWKRSVVKYGDKVTAVQYVRLDSGSRYSTKNTNNLKVAIGLVINDLRTSSTHQAHTIHPLLSTHTAKLTTKFSINTTTGEIHSIHVKTLMDDLRVSVFKFIKLYLTDIETRIDKLGGADAKDVDPAVQEAEAQRKARRLERLVGIFKVVYEAINEISVVAQNLNVFEIPFITTDCNESFKAYLQQEYPITALELKTKSIHLHLQKLSKTSAGFHALFESADDKPINISNSVQLLTVNFAKWKNINGSFHKNQVEVLNIPTYSLSCKANYFDKLIRGEGFQNCIAELFWTCSNPILDLDSPFLTSLLHNIVILRKLMKFKSLQRQYKLLVSSSYSTDDDIDDTQQDYYDFDETLIDMPEKGFQGSKTPLKDKLWRYLQEYYPKLDVKFIIEQPRLVVRHTSTTSIDILDFSYSSLNFSVITTKTRDYNLNCSVLAPAISYAQNSIQGDSSVKFDIVSLKSFVADVQVLKNLKFKFDFNFESFHIDFSNLTTLVGIKTIVNQLTRLIEMDLQRGHINLFLNSRISKYRTFVMNLDQENPSDVYKTLKETLFNYLPAWFVELNVVADDVDFKFGSRSVLIPKEKLSEMLQEYDLKDFLESDSSCELRCFRIQLGILRFGFENNCNPHLDLSTSSLSSASSDTLTSKQDQSISYWGNNLEIKDFVLSAMSDFSGPRHYGQCIAIPNVSIDVGCKKIQAKENLNVSINLNKIEGKVDHFKCFTIIGAGYLLMEHIVRPLQSIQSKLKKDAGSISEKPSKSNFKSLKDCITISSKIKRTDLSVTLSGDYKVRLDSYETRISLADDTISIYDKYFRVLISSPTVEDHWCRLICTDDFQFHVNLHDIRNLYVNTSLIKIAHPHGHIAYKLFDNISITLKVLKHSIRAFNSGDAEKDNDFTVVHPSESRPKEFPNINFKTNKLMFNMEDDPFESELGMIFQLGKVEQLKRIELYSLFQAKTQNLQSTEKHDEIKSIEDINDENDLPGKLDDLNEIISVSWIRKVKRYKTMLNDELVKNKKFLFGNEAKLDSRFQSKILPYSLHAPLLSIVIDSLNMVISKPTFDLETLPKFLHDLGQGLPFDTRYSLILPMYLDLRMRELRIHLRDYPLPLLYVSNSKAESASAVKMYGDLVISESLVTEEHNIRKLMVDLTRNLKKFQFSEYYRLEIEKTMATVKIFTDMKIEFSTKLPSRFVWGQSYQFAIQQVMLNFDSFSKPPLDPSPKLGFWDKLRLVIHGKFDIKCTKGPLEVAFKGSRDPYNLFGVASGFILSFKDNVVWTINQNDDSRDFCNVKSDKISWYIPNYLASGLVSWTRETNRLTYLPNSKKFITSCYAYYLDDEDYCIPRNKVNSNIFEKKVVSLSGGVVFKVGFVLQRDGDDGQRTEECKSHYDVKLFNPQFTEEGHDSYKDFRSDYINMAISMDANFSESYNSIHLSPRVFMQFFDWWKLFSSNMQLPIKKGKIFGELKKSEKFSQHLVSNRFKFNLKSLFISHIYREENSEEMEDQIQSCGLKGKMNSFVVDLHQRKEKRIAVHEGISRNKNIMKMTFHIADVHLNGIDLRVVTATFDHNAYNTPGNVKESKYDIFDNDEQWFDIEDYEEAFLSSLASSKRQISVLPLMYSERFSYLRDTEPGIRFKEVDLFESGKASLERIKDVARAQKDIVSSRIKQLKDEIKLRRSRGLSTKDLVGRIDVLKKEMSKASVNLDRRPSVSDFNTKFSNKFIVMRMLWKWNDKNRNNFFKYVHFVQLRTFLKRYLSFDSISALEEIVEYSTEGLDRKSTYSKSEHSPGDKFAKLSTDEKSGKSRDRLTKFDEILTQVAKNENLVEDYLIEIISPQIQLQSSETPDSVIIVSSPMIDAKLVSIYDKSKDRLLLDIDELENRLAVMINNANVLVFEKNSVEDNNSFIFDQTCYGSTSSWPPWLGIEICNQATLAGSKNVLLEDTSVMITYIQSKPTGAKFAHDSEGDDLSKVSTNTSKYFDLPGSKKENIQNKLHVDIPTVNITSTSAQYFSLYSIITNLLLYTEPSNKQFNDKLEKLKFSINFQDLAALYDRIKALHLQNGILNLMSNNYNFRQDTLDNESLNDFITLKTIQQEISNELYLLLHSMLTGNSHVKDSSKSPKAEWIINADELILHMLEDDRTPILDIAMATGKFTRIVNEDDSNINRIEISMIQGFNLLRGAIFPAFIEPMDHKDELQNLLTVDWSMYSNVGGIRLIENFEVNAQPLSVRMDKITGDKLMHFLFKTELADLTDLGDNPMARHEAEVTNDLDFNGKASNGDEKSKVNFDTSSSQSDPSDSESSTNPDQLTIGSPSKRVTNRSSHLFPKSFTQSSGSEQQYDEQLDVMVNRSKNYVSVNSLKVNPVSLSISIKLKGGYKRLLNVEDFKLVLPEILIQKKILSVLEFTMIVRKILVRAILGHLGGLVRNKFKRSKRKPMNLINKPLKPLKRYARFTSVTELRGGSNEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC19</accession>
    <name>G3BC19_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_137235</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10573</strain>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC19"/>
    <dbReference type="STRING" id="590646.G3BC19"/>
    <dbReference type="KEGG" id="cten:90981761"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_0_3_1"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 16" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV60758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="429" mass="48610" checksum="68D30D2DF6034681" modified="2011-11-16" version="1">MLNPQTTDIQFNGSVGAVAISLGLPALLTVFGIVLNSQSPFKSGIPFPFDWSFDRIANAAFDKNTWIAYTTYFFGFVVLDQLVPGKYIKGVVLRDKTQLTYKINGLNFILVIVTVLLARLYALGSLPELEFIYEHQLELTLTCCLFSFALAVFVYIYSFFPLKTPNGLGTNDRILAEPGNSGRVVYDWFIGRELNPRIGSWDIKLFCELKPGLVLWLLINVSCLYSQYLQHGTISDSMLLINFLQGFYIFDGILNEEGLLTMMDVVTDGFGNMLAFGDLALVPWAYSLQARYLSLNYIDLGWPYCAATVAIAALGYYVFHSANQQKSDFKQGKLAHLKSMKTVTGSNLLVDGWWKLSQHINYLGDWLIGLSWCLATGFNTPLTYFYAVYFASLLVHRQVRDDEKCASKYKQSWDEYKARVPYKIIPYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC21</accession>
    <name>G3BC21_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116829</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689976.1">
        <property type="nucleotide sequence ID" value="XM_006689913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC21"/>
    <dbReference type="STRING" id="590646.G3BC21"/>
    <dbReference type="GeneID" id="18248465"/>
    <dbReference type="KEGG" id="cten:18248465"/>
    <dbReference type="eggNOG" id="ENOG502RQ0A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648900_0_0_1"/>
    <dbReference type="OrthoDB" id="4026708at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="423" mass="46351" checksum="89B4B4A342F171B7" modified="2011-11-16" version="1">MVPNTLLTPYQSLSSVMNMNLQNNTTSVPVLAPPPVVPPTPKRKRGRPPKPNNFSSKITKTINISVNTSPLSNSPDAENNSNQTVKRGIPDIFTPTMRVSPSAGAIRRRKKSSVDMGNSPARRKSSVHSLSHGSSSSSSQNSPATDYINSRTLDNISQITNSGRGAYQSPPPSAKQQGRQLDKNLLPPVLIRTDRAASPVQDLSDFGDFNLKLMIDESGKAVLSQSQANTTIGIQGHYDSAPTTTATGDLDYGQAPVQYHHHQQQQQQQQQQQRPMPMKYHSDYAFSDTNPPQTPKQKDYTISTGLTPLGFGGNYSTPQFNSLMNSIITSPKKVGNNNNQFMFNQEMFMNSGFDFMNGNPLLQAPQQSTMMQQQQQSPSGGQFNTGSVGANVGYQPQMTQPLQFPDDSDARLALKKIMHVKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCC0</accession>
    <name>G3BCC0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_96236</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690012.1">
        <property type="nucleotide sequence ID" value="XM_006689949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCC0"/>
    <dbReference type="STRING" id="590646.G3BCC0"/>
    <dbReference type="GeneID" id="18250589"/>
    <dbReference type="KEGG" id="cten:18250589"/>
    <dbReference type="eggNOG" id="ENOG502S81F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141719_0_0_1"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="113" mass="13419" checksum="29BD18954E60FC45" modified="2011-11-16" version="1">MFGAFRASLTNHGGYLWKSAPRLSSPQKSRLRQRMKTVDANIEAIYQSLPKDHNGLTSYRKVDYLKFKFPKENEMSAKDKYTTFDKKAKDYRKLVFKVPKWTKKSFRENPMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCK7</accession>
    <name>G3BCK7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116248</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690259.1">
        <property type="nucleotide sequence ID" value="XM_006690196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCK7"/>
    <dbReference type="STRING" id="590646.G3BCK7"/>
    <dbReference type="GeneID" id="18248214"/>
    <dbReference type="KEGG" id="cten:18248214"/>
    <dbReference type="eggNOG" id="KOG2975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_0_0_1"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="2">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV61045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="329" mass="36460" checksum="C16582DAB3D9126D" modified="2011-11-16" version="1">MSATTSMHLVRPGVSAPGASSTTTACNVKIHATAFIRILEIVAKQSISKDKRIIGTLLGYRSDDGSGFEVRDAFMVPCDETGDSIAIADHEHKVSYQLYKKAHPKESVLGWFGTSKQIDNSTGLIHDFYSKGSDRAFPYPAIYLNVNYRDENDQVINPQVSTYIGSTVGKVATGQKVGWKTQSSVNSYVFHPIPNQIMSGTTTEKLALDSLVENHINQTPTTFSGNEVNDLSNLKKQINIVVASIDKLAQHLDSFDINNDNDLQLLRTLTNNLSSRPQSLFNLDELKKHFGAYNQDVIMIEYLTKVVKEQIELSARLTATAESEKKDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCS7</accession>
    <name>G3BCS7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_128577</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573</strain>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCS7"/>
    <dbReference type="STRING" id="590646.G3BCS7"/>
    <dbReference type="GeneID" id="18249317"/>
    <dbReference type="KEGG" id="cten:18249317"/>
    <dbReference type="eggNOG" id="KOG2872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV60874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="362" mass="41044" checksum="D4BD68BE7DF54443" modified="2011-11-16" version="1">MGEFAPLKNDLILRAARGEKVERPPIWIMRQAGRYLPEYHEVKGKRDFFETCRDAEIASEITIQPINHFNGLIDAAIIFSDILVVPQVMGFDIEMVEGKGPVFVDPLRTPADLARVNYKPDVLKGLDWAFKSITLTRKKLEGRVPLLGFCGSPWTLLVYMVEGQGSKMYRFVKQWIYEYVEESHKLLQAITDCCVEFLAQQIVAGAQMIQVFDSWAGELGPAEFAEFSLPYLKQIAEKLPIRLVELGVQEKIPMTVFPKGAWYALDELCDIGYDAISLDWLYDPEDAVKVVNGRRITLQGNLDPGVMYGSEKTISKKVEKMIQGFGGGKQNYIINFGHGTHPFMEPAKIEHFLKECHRFGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BD36</accession>
    <name>G3BD36_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_132545</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BD36"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="58153" checksum="2D700D01A83DD22B" modified="2011-11-16" version="1">MSSDKSLPRDIENYADVTLDLIQKNGGTVAELTPEKERKLKIKLWLTIVPIAFLVNATLFIDKDAVTFSSLLGLFDDMGISSPDYNNIQTFFYLGYFVGQAPSHYLFQRFPVSKFISATLAVWAILSFCTLGCKSYAGMAVLRFLLGAFESGITPCVEHTLAMFFTLEEQAFVNPVFWISCLGIDLPFAFVAYGLQYTTKWRPWKWYWLLIGIISSVVSVVVYFIYPDNPALSRLFTTEEKIHIIQRVKKQSRSSIEQKTFKKYQFVECLKDPISWLFVLFCLMNMLENSTSYQSSIIYTELGFGHLTSTLLIAVTTAFSISCACAGAFALSRFRKQSVFVAVVFTWPALLGAILAVSIPWDNKPGILGGIFMTRSNGTAYIISFSLCQTTAAGHTKKLTRTLLFMLAYAVSNMVCPQMWRTQYQPRYRIPWIMQMVFSWFLAPCCLLTIRYILSKRNKERRRLIEEEGEDLDYGFIDSVDENGDLVKDKVDVSMLDLTDLENKRFIYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDA1</accession>
    <name>G3BDA1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_110734</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDA1"/>
    <dbReference type="STRING" id="590646.G3BDA1"/>
    <dbReference type="GeneID" id="18246218"/>
    <dbReference type="KEGG" id="cten:18246218"/>
    <dbReference type="eggNOG" id="KOG3719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_4_0_1"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV60279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="737" mass="83588" checksum="6192004137E5FB0C" modified="2011-11-16" version="1">MTYQYQDQLQKLPIPDLHQTCTNYLRVLKPLQTEKEYEKTMEAVAKFLKSGTGKYLDEQLREYSKNRNSYIEQFWYDSYLNYDSPVVLNLNPFFLLEDDPFNNESNSINPQVKRAASLTLSSLKFIRALKNETLPPDRLKNDQVLDMYQYSKLFGSARIPTDEGCVMQSDQNSNHIVVLSKSQFYWFDVLNGNNDLILSESDLIINFNSIIKDSLDTNADAVAKSSFGILTTENRRVWAKLRNTNLSNNSSNREILSIIDSALFILCLDDIKLYDLSDLAKNMLCGLSILDRGVQVGTCTNRWYDKLQIIITQNGKAGINFEHTGVDGHTVLRFVSDIYTDSILSFAHQINANSPNLWGDEGKKASIDNSENLITIPRKLEWDLTPDLSLALRFAETRLSDLINQNEFKHLEFKNYGSSTIKNMKFSPDAFIQMAFQATYYALYGKVECTYEPAMTKQFLHGRTEAIRPVSQESNLFVRKFFDSSVPNKTKLEFLSIACQSHSKQTRLASNGEGVDRHLFALFCIWKRYIEDEANEANENDDSNSDRTLGNEIQFTGPDKSSLQEIPSLFADSGWDKLNNTILSTSNCGNPSLRLFGFGPVSANGFGIGYIIKDDSVSICASSKHRQTSRFLATLESYLNEIYRIFKEVNSPTNEFLSSPVETKHTHSPASTPIYIENPKPAAYNGLSNLLGGYGYFDMGDDDIKSRGPSPEPPFLNRHNSGFSIKEIGKKLRLSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDL9</accession>
    <name>G3BDL9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_136814</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDL9"/>
    <dbReference type="STRING" id="590646.G3BDL9"/>
    <dbReference type="eggNOG" id="ENOG502S2EI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4089784at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="270" mass="31336" checksum="D38448770B67C927" modified="2011-11-16" version="1">MAPMDKIYNLRHTAEVETICEMAVLFASMATNYIIYQTISRNYQRYGNVAWIDCFVYTRSSTDAPDRSDKYVNSDSSDSEEEYVYEPSKHFRPFVPAPVSSSDFGDKQVWLLKHPKNFKFKVSKLPINFKTSKSKLSQGSSSYDIVESSSDNIDGEDEYSKYQIFINKQNGKFTGSDLKITKFYSINEVVDIPEIDWEAVKKPRTDVPKVENLRMRHFPTGYEASDFVQDTDVRVPATLKSESSSKTEKKEKKEKKEKKHKKDKKEKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDY8</accession>
    <name>G3BDY8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sure-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_127629</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDY8"/>
    <dbReference type="STRING" id="590646.G3BDY8"/>
    <dbReference type="eggNOG" id="ENOG502RXIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_0_0_1"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442853" evidence="4">
        <location>
            <begin position="17"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="317" mass="34095" checksum="1F9611D4728520AC" modified="2011-11-16" version="1">MKFFTSLLSVLSLAACKSILLSNDDSWVSSEIRALYRELVADGHDVIMVAPASQMSSQGGAFIVPDSSDLDSDGNFGYVSAGDPAWGQDPDDPHIWYFGGSPSACISFAFEYLLPKSYSNVTIDLVVSGVNQGPNISPGYYTASGTISAAYSGIYRGYPAISFGGSNLNNSFFQDSSANDEYDPANIYAKKAVEIIDLLVDADLPSTVGINVNFPEVGYLLDNETECTDPVWKFGTMMNGGYFAPIVKYDSSSDTFSSSYKLFKDSTCNDGSGCNLPSEYDIFWARNCTTSVTGFQVDVSLPGSMDTTVKGIFDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE05</accession>
    <name>G3BE05_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cse1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_111601</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE05"/>
    <dbReference type="STRING" id="590646.G3BE05"/>
    <dbReference type="GeneID" id="18246299"/>
    <dbReference type="KEGG" id="cten:18246299"/>
    <dbReference type="eggNOG" id="KOG1992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009614_0_0_1"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="982" mass="112255" checksum="CE52464644F18D37" modified="2011-11-16" version="1">MAENTLESIATCLERSLSPQYARIAEQQLKDIEMLPEFSVNLLKIISAAQVNNSIRLSAVIFLKNLIKRKWVNENGDHLLPVSDVEYLKTEMLNVMVNLPNNLQVQIGECIAIIAESDFPHRWGSLIDDLISRFSTSDFKTNKSILLVSHSIFKKWRPLFRSDELFMEIKLVLDNFAEPFLMLLTKIDELIDTSLAQRDQANLKIYLDNLLLLIQIYYDLNCQDIPEFFEDNMMNGMKIMHKYLNFSSDLITDADDDEEVDVIIKIKTSVIELVNLYITRYTEIFEPLIENFIKIVWELITTSITKQQKFDLLIVKCLQFLTLIIKLSNYQNIFNNEDSLNEILKKIILPNIYLREVDLEMFEDEPINFVRFDVEGSEFDSRRKSATDFLRELKEINNELLTDIVMRYVNNFLENSNDKANWQSKDLAIYLFSSLAAKGSVTNIGVTSTNVLVDVVKFFSENISNYLLAANTASIHPILITDSVKYILIFRNQLTKEQLLSVLPLLVSHLTNPNPVIYTYAAIVMEKLLSMTSFAEAHEVILNKFDLQPYLNDILSNLFKLITSSYDKPPEKLSENEFLVKSIMRVLNTSEDLVPFDFKKVIITQLLDILAKISKNPANPKFSHYIFESLGLLVKFSSDDKVNELIVLILPNLLNILNEDVQEFVPYTFQVLAYMLERLPGNESSNLPSEYTQLIKPLMSPNLWQFRGNIPGITRLLISIIKYDYKVFSTHETVTPLLGIFQKLIASKLNEVYGFELLETILLYIPLRVLEKFLKSIAVLILTRLKNSRTEKFLKRFITFVFSISSLPLNKSLNIRNPGLNANFIITLINLPQPGVFEQILSNLVLPNLSSFQNLRDKKINLIGLSQLVNSDLINSTLKIILLEQIAKSSTSLMSLNKDVIANADDLKNVALSELDLDVGSFGSNFSKLVTIQVEPFDPLSEIKNNDLNHIKQIVSNGVKLVDGSIVSQISLESQNALQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE83</accession>
    <name>G3BE83_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator HFI1/ADA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_132231</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE83"/>
    <dbReference type="STRING" id="590646.G3BE83"/>
    <dbReference type="eggNOG" id="ENOG502RX84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033254_0_0_1"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22933">
        <property type="entry name" value="HFD_HFI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48944" checksum="35E56651E9E59B36" modified="2011-11-16" version="1">MSTTSTTNASGISKKSNNGALAATSGAGKRNHLEQLIRELQNKLGPNWDKYHENLSLFLIGKLSRQELVNNIVPILKNGLIKYHNQLLLLNFANSFKNIPIDFQNEFASFWNKKSKNKSVKSSQYEKFKQNIMGLPIKERRRIRAITREAGKKNKINAGITLTRHALLPKIPSIQDKEQQQLQVNNLVGWQQDVLNGINTPISTDTYELPDNDDLSKRIIMVMREAGLTGGINPQVLEVMMLGLESYLKNIVESTIDVARYRANKYNNSDFISTAIQTVNESINDRKDSSKANEDERDPKRRKVTLNIHDMFDSLEMFPYLIEPTGTQTRLNSVMLKNDDEYEGIDYELPPKIEEEQPKLNGTAKEPPFIDKKLKDDSKNSITEIDISREKPSDSAIVSQSSSTPTKPKVQSHIGSIDELKWVLHDLYSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEJ5</accession>
    <name>G3BEJ5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_99945</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689772.1">
        <property type="nucleotide sequence ID" value="XM_006689709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEJ5"/>
    <dbReference type="STRING" id="590646.G3BEJ5"/>
    <dbReference type="GeneID" id="18250890"/>
    <dbReference type="KEGG" id="cten:18250890"/>
    <dbReference type="eggNOG" id="ENOG502S99Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086433_0_0_1"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="207" mass="23217" checksum="62D91ECB1E118F65" modified="2011-11-16" version="1">MARSFYEDDEVVITKPGYNAEISKDLKQQQGAHGDVSLVKGMTIRTVPYLESSLNKARLYLHDKLSVIEAEIDTQISATRNELNTLSTKVSTSIKDPVLPNIIYILTLTLTGSILASKSSLPTRFLAPTLFGTASFAYYMPQTFQGTKAKLVYFESEKFPEVFQQQSKILKELDNQKTQLEATLASTETSLTTVVHDARVYIYDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEK4</accession>
    <name>G3BEK4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SUN-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_96012</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with EMP65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEK4"/>
    <dbReference type="STRING" id="590646.G3BEK4"/>
    <dbReference type="GeneID" id="18250568"/>
    <dbReference type="KEGG" id="cten:18250568"/>
    <dbReference type="eggNOG" id="KOG1396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006633_4_0_1"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000099">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="12">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="371" mass="43374" checksum="A6DCFF68A75F12F4" modified="2011-11-16" version="1">MSFESWKKLKIKSDPTLKNTSQISPVKNDENRFNFASIDCAAKVVKTNEGAQESKSILMENKDSYLVNKCSTKDQFLIIELCQDILIDLIEIGNFEFFSSNFKRFKVSVNERYEDTNWKSLGEFEASNSRTLQKFKIINPLIWAKFIKIEILEHYGSEFYCPISLVKVYGKTMLEEFKEQTIEQPSVETDECKINSTLPYLGLNEFLNSIPEYCEVVEEESTATNNPQDSIFKNIIKRLSLLESNASLSLLYIEEQSRLLSDSFRKLQMEQSHDLDKLLWNFNQTFNQQMLKINQFNQFKLFESNKVISNLANDLSFYKKLLLVNFVLLTVLVCFLLLSKDLPVEIPIPRNYQFKVGSTKKKYKKKSKYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3BET0</accession>
    <name>G3BET0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116664</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BET0"/>
    <dbReference type="STRING" id="590646.G3BET0"/>
    <dbReference type="GeneID" id="18248394"/>
    <dbReference type="KEGG" id="cten:18248394"/>
    <dbReference type="eggNOG" id="KOG1626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040684_0_2_1"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000007">
        <property type="entry name" value="Inorganic pyrophosphatase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="321" mass="35864" checksum="4332C6E7B38D67DE" modified="2011-11-16" version="1">MAAGYKTPWNIATQRLQLTSNHLTAPVNSRSLSYSTVDSGSKYSVDYKKYLTDTNGNVKSFMHDVPLDLDTRNGTATMVVEIPRWSYAKFEINTKLEGNPITQDIKKGNVRFVKNLFPFHGYVHNYGALPQTWEDATNSNGSLGLYGDNDPLDVVEIGSQVLDTGAIERVKVLGSLALIDDGELDWKVVVVRTADQLASQLHDIADVQTICPGLLEATREWFRNYKIPDGKPANQFAFNGEFKNREETIRLVQENHEAWDKLVHGHIKADAAKLPNIANTSVSGSLKYQEAYDHKTLSLNPSTPDMPLPEHVDRMYYCGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEY4</accession>
    <name>G3BEY4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho1 guanine nucleotide exchange factor TUS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_131866</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV59965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3BEY4"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004667_0_0_1"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="527"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="760"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="972"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV59965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1310" mass="148110" checksum="4336AFB4510CE1AC" modified="2011-11-16" version="1">MSGDSPHTTPSRKSLRRKPPPAFPQPNGPENAEFAPSASPSILHISTPAIGISEAYDNHVFQPVGLEGGSYRPMGPKELPEYDPNVTNYDPMGYETFERSPPYPVQDPAFIESPVDMEPMSPSRDPWQTTFTPSRKAEILDQSTTTPTKIPFLGIPSLSANGRQRRTPSPERINTFSTPVPRASRSPSPKKLYGRSPSLIYDRFQRDTADELVFDDSFVENDEELVEPEWEPIHDSDYESEPEESPTTGFFDYSILPDLPSAITKEESTDGSPTKRMTLNSAISFVKGNTYFDEEGLVRMGTRKKNEDLPPVPLDLPKLPFSSSSLVSRHFSECPNVWCLSDVFSWCLKLRMWIHDQLISKKEFKRALIKLLVYHKRDVPLDTIGPNVDQIVSSLVSAGAIAFDYGTLPNEDGEKALPNPVGIPDDGKPTKSNPGVILYEGVHVSGVLVDLTSCYCNSRDHKHENELKLGDVKLRCFSSQCYLNRVLDYEAKFRNTDINEIVLGEDWASHWKLTADDLKQYDKDVSKKQSLLFDLLRYEQTFIQRAKCFVEVVGPDFVKAVRTLIGSQQIVSMGKFDDDVINPGKELLQIHQKSLFEPLLKILISNGKFIKDIVDIGNIYYNWSQVVKPALLKYMSTVPMIEELLNTPVIKQWVDVNVRKMTRVKELKVNGPLLFMSTFNSRYQQLPLQLSDIVSQFDETDSDYAALMKAVNGIKRTAARVNEMKSHADNIHCLKRISQQLVWKSNVAKPNLNIGSENRRLIYRGDLTRKGDLRINSSLNQIILLDNYMLITDRIKNSKSPMAQYRVVENPIPVEFLLVEVREKESPTIELNSITKTLTSSPQQAYPRHELLVDQEDPSIYPFKVRHAGHGKNNSFVFSTKTERDRTIWVNHLMDARSNLCSRLNKVEPYNLKLISNTCFAYEESNRVTKLQSLSPNDPIEKMSTNSLSIMNSLGYTGDLYSFSNTSKHVVFSTVRSSASFAYNSTNFFFVGTSSGVYCSDMVHGWKRVVSISDTTKISVLPKINLVIMLSNNSLRYYPLDVLINYYYGRRDTVSSVALSSDAVSFFEVDKHREITMLFYAKKKGNSSGATNFKVCVPETDNDGIFSAFKVVKKFYVQAECFGISIFNSSFAVYTSKGIEILELDKLLPRSVPEIPNLDSSTKKIDVYSRRSLPTTPNAPEIDNIRRAIYGTSSKPMGMFKLNNNSEFLLVYNECAVFINKHGKLSRFSMLRFDYKARSIGFQDNHLFIVCEEAIEVWSISDFVKGTNRLIQVTVGKGIRMVNSQSLIFSMANPTVPGLQLVFQLSTKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF75</accession>
    <name>G3BF75_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116716</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF75"/>
    <dbReference type="HOGENOM" id="CLU_2503810_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="86" mass="9762" checksum="C999AD9FF2EAB3EB" modified="2011-11-16" version="1" fragment="single">IIVDGYEGTKILGLTCHISRDSAILRALAFTSLSPLLSPKNYELHLPTTRDEVMRHMFRIYSQLVRQPRNVLSLLLEVQTTLIARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFL2</accession>
    <name>G3BFL2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116071</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFL2"/>
    <dbReference type="STRING" id="590646.G3BFL2"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512858_0_0_1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="71"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV60042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="484" mass="55505" checksum="3215309A54A71991" modified="2011-11-16" version="1">MLIRKYAFLQPSPQNQIHTNSNQGKWNLSEIPKPKCVGDVRFMKPPECYIESSRAKVVNEYTNLKQWDEKPIFKKIISRARKQFNVSGVSISIVNSKKVVFKYESLLNASEVSRPASIDGHAIVSQDYFLLLDASKDWRTTSNPFVDGIPYIRFYCGVPLMAANRKDIVGVVAIFDSFPRKSFSNESITILKQLSSEITQVLNTPIEDMSLKYKNVRANSKYSTARYDEKMTELHELQIKLGRATSRGSLMTVFEKDGPGGPYSQNNNFKFLTKLTDEAEQEEFVNNNSLFEKLMKTGTIKRASNLLCKILSVNYKADFVYILEIRIAESYEIESKYFPKENKIESDSFAYANKLVKRPSDKNEFMSRIMGCYGSTHTSLNFENLIHHKCFEAEFGIHYKTKTNSSIYNVGVLMPFYRHSSKMVRQKKLRSLKGDKNPKTALFLRSGGYIVGLFNKEGEKKFDDQTISKVFNNVSVMRKLYISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFV5</accession>
    <name>G3BFV5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hexaprenyl pyrophosphate synthetase mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_111901</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFV5"/>
    <dbReference type="STRING" id="590646.G3BFV5"/>
    <dbReference type="GeneID" id="18246326"/>
    <dbReference type="KEGG" id="cten:18246326"/>
    <dbReference type="eggNOG" id="KOG0776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_1_0_1"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="461" mass="50670" checksum="4EEB87BFB0C02E6A" modified="2011-11-16" version="1">MVSTQPSSFTAAVEAAEKLVQPQNSQSFSDPFSIVSHEMSNLAKSISNLIGSGHPVLNRVSSYYFEAEGKNVRPLIVLLLAKSLSQIPLEQRNRIKIDSLDVTDQKPFSGTPSQTVVAGKSVDDSLSPLSILYGINPKVILDPLSKPMDRLPEFDAMNGILPKQRRLAEIVEMIHTATLLHDDVIDSSDSRRGRPSGNIAFTNKMAILAGDFLLGRASVAIARLRNPEVIELLSTTIANLVEGEFMQLKNTVIDPAAENSIDNDGESKTVPEPSGKVPTKTHEYTVTKPVDFDHETNVNAAFEYYLHKTYLKTASLMSKSSRAAAVLSGAQSDIIDNCYEFGRNLGLCFQIVDDMLDYTSSDSAFGKPSQADLKLGLATAPILFAWKERPEIGDLIARKFSQEGDVELARKQVEECDGLEKTREMAKLYCQKALDNLRVLPESDSRSALEFLTNSVLTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW14</accession>
    <name>G3AW14_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Curved DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112159</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683684.1">
        <property type="nucleotide sequence ID" value="XM_006683621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW14"/>
    <dbReference type="STRING" id="590646.G3AW14"/>
    <dbReference type="GeneID" id="18246378"/>
    <dbReference type="KEGG" id="cten:18246378"/>
    <dbReference type="eggNOG" id="KOG2776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041451_2_1_1"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="385" mass="42812" checksum="65B2F680D2868CB0" modified="2011-11-16" version="1">MSTKTTKTEKVDYTIANSDVVQKYKTGGEISSKVLKQVRDLAVAGSKTFDLCQKGDELMEEELSKIYNSKKTSQILKGIAFPTCVNPNHIPAHFAPPTAEDEANVELKEGDVVNIMLGVQIDGFPAIVAETVVIGESESSPIEGKKADLLHSAWNASEAAIRTFKPNARNWDVTQIVDKVAKVFDTTPVESMMSHNQQRNVLYGPKEIILNPTKENKSQSDTHRFEENEVYGLDILISTSTDGKVKESKYKTSLYKLTGNSYSLKLKTSHQALGEFKSKASGLFPMNVKKLEDIRKSRMGLIECVSHQVLLSYDVMTEKEGEFIAQYFTTFGITKNGIVKFTSPTFNPALYKTDKKIEDAGILELIAKPLKTNTKKKNKKPAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWB6</accession>
    <name>G3AWB6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_112221</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWB6"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="104"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="552" mass="61668" checksum="DA6AD6A13AB264CC" modified="2011-11-16" version="1">MGLSTFVHQSFWGRVFYHFSGGKLFSYKEEAPDYIIPDKYLDTKKSQIEESEETVEDSGSSVSSSNSASDCDTETLQVGDRILVTWDGEDDPDNPKNWPLWQKIIFMFEISFLTVSVYMASAIYTPGVDYIIEDLGVSKIKATLPLTMFVVGYGIGPMIFSPASENAIFGRTNIYIVTLFIFFLLQIPISLVNNLAALTVLRFISGFFASPVLGTGGASMGDVIDKPYMPIAIGVWSMGAVCGPSLGPMFGSIMIVKRNWHWTFWLICMLSGIAFVILSWFLPETYEKTLLLRKAERLRKLTGNDKIVSEGEIENQGLTSRQLFIDTLWRPFEIMLFEPIVFSIDMYIALVYSIMYLWFEAFPIVFADLYHFALIPLGLSFLSVLVGICCSAVVYVFIMHRKYTKRKLRGEYVPPEVFLPTMILGSISMPIGVFIFGWSATAKAHWMGPMIGAGIFCFGAFINFQTSFNYLGSSFPRYLASVFAGNAFLRSVIAGCFPLFGAPLFNNLATPNYPVGWGSSLLGFIATIMIIIPVVFYLKGPSIRARSKYSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWC1</accession>
    <name>G3AWC1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_100439</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683766.1">
        <property type="nucleotide sequence ID" value="XM_006683703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWC1"/>
    <dbReference type="STRING" id="590646.G3AWC1"/>
    <dbReference type="GeneID" id="18245379"/>
    <dbReference type="KEGG" id="cten:18245379"/>
    <dbReference type="eggNOG" id="ENOG502QR55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070142_0_0_1"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="270" mass="30942" checksum="94393144CCC96304" modified="2011-11-16" version="1">MISTISHASTHLYPTITALLSTRKDKKYNRDRWTLQELDNWKDVELPQILKRRVEKQDGCYLTVPELKLLMDWKLAKGKFRPMLPKLISANLADDVERVTRTAMMMFVDGVCEFESLAGESREKYTQLVKKAMVELCRLKGVGPATASLVLSLLWSVSALSPPFFSDESFLYYVRPATKIKYNLKEYTDEYLPVFLGILEQEDEVTMNSLEKGGWALKMLEIHRDGILKGVAVGPYEGFLDHYADKTRTTKKRKLVDDKVPTTKRKHAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWJ6</accession>
    <name>G3AWJ6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_112274</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWJ6"/>
    <dbReference type="STRING" id="590646.G3AWJ6"/>
    <dbReference type="GeneID" id="18246440"/>
    <dbReference type="KEGG" id="cten:18246440"/>
    <dbReference type="eggNOG" id="KOG4772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028449_0_1_1"/>
    <dbReference type="OrthoDB" id="4014169at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="363" mass="42519" checksum="FA9ECA1621B10708" modified="2011-11-16" version="1">MDIEDDDFTFNNILLDQADEVLDYRFLTQSLPKTGEKDFEPDGSAFQSNKIEDSKELMYSMLSQELKAHERQVVEGIFLPWEGQTLIVTIRGNYFRDIGRNIPFKNKSAVLLNKIETLYLVERGTLIVYLGNDKFRSYLDGLINSFSFRDLDPLNLQYVYGLLTSFEIEKYQVFAYLKRLGYLVQDYRHFVVQILPDEHHWLSPWRISWFGSSNRDLLGVNIKSIHYQTYSQILKKLSIIPSYAPYESLKENFNDSEFQIHYNVWKPRPAFSKKLPPTPDFQICITKAFPQLHDIRHLFNQLNHTALNIDFEDLEMRTKDHKLKHGTGRTIVLAIINNGVSFVNLSETQFSLTHKNKITGYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWT0</accession>
    <name>G3AWT0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_117698</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWT0"/>
    <dbReference type="STRING" id="590646.G3AWT0"/>
    <dbReference type="GeneID" id="18248588"/>
    <dbReference type="KEGG" id="cten:18248588"/>
    <dbReference type="eggNOG" id="KOG3065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020823_1_0_1"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="399"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV66608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="462" mass="51574" checksum="1A9FF8726099D62F" modified="2011-11-16" version="1">MGIKSVFKKKEPTEDEIRDHLASRGITSKSTAGGFAGREEKFGAFKEYAQTRASQKSAIRPVNPYANLNGNAAGGGQNAGSNPYAEVPPQGVNPYGLNGSSSLSSNPSSQNGLAAPSDPYAQRPRQGLQSSSSRPPSSSVPDPYARSTRSSTSSPDPYARSTRTSTRQRDFDEESLDLNAIPSNTMYQNARRPTKKAVALDDATIDLNELPEEDDLNVVLDEELPEQEQVNSEDEEVEGIKQDIRFIKQESTASTRNTLRMAQEADASGTNTLGVLGSQSERLYNAEQNLNLADTQTKIGEEKIKQVQRLNRSIFIPASGNPFNKKSRLRSQEQRLKTEKEHEKYMRDSNRKNMYESEQRIKQGITQNASGSELHQKYRGEKNLASAQRYQFENDSEDDEMEKEIASNLEQIALYSKKLRNTANTMGQEVDSQNDRLRKIEEDADRLDINVHLNNTRLSNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWZ5</accession>
    <name>G3AWZ5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FSH1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112370</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWZ5"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_2_2_1"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF9">
        <property type="entry name" value="FAMILY OF SERINE HYDROLASES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="238" mass="27239" checksum="F612C1BF8FC121FC" modified="2011-11-16" version="1">MRFLVLPGYLQSGKTSAEKSSGIRKLLKKANHELEYIDPPRVLSSPSELAFKLGDTQEEIDSKWQNIVDANNNRCWWLANDTNPYLGFVESYNHMVKHITENGPYDGIIGFSQGAGMSLILLQQFNFKVCLSFSGFCFTLPSDPSYDKVNINYQIEDPEEYKSKNMLNDEYKKYYGSDTPILNIYGNNDNLVPRVRSIFIESVFKNVESYEFEGGHMMPNKKPFLAPIVERVNSIDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX33</accession>
    <name>G3AX33_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_96676</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX33"/>
    <dbReference type="STRING" id="590646.G3AX33"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="105"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="370"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="441" mass="50810" checksum="B7CBBBAEC92CA7C7" modified="2011-11-16" version="1">MSMFNMDDIADQVDRLNYRLVDSDMDPDPADPFTPGLHPTRSSPVFDDSDPEPDDTDDYIVTDYAGADVTRLDIPRRTSARRGSHSVDLRINEPFISSSPTLDDFEPIMVLGKGTYGKVLLVRQKTTGKLFAQKQLKKISLLMNNEVNEVNLERTLNEKKILERVNHPNIVKLYYAFQDFNKVYLILEYLDGGELFYHLSQESFLPESKACFYIAQLVLALRYLHLQLHVIYRDLKPENCMLDSSGSLVLTDFGLSKVSDKDKTNSFIGTIQYMAPEILRNENYSYEVDWWSLGCISFDLLTGSPPFTGNNNKKITEKILASKKNLKFPFYLSLDAKDFLRKLLAVNIDKRINLDQDDQFEAIKKHRFFRHINWDDLIHNNQAVLPPILPVITNPLLAENFDKEFTEMAFTPPMTKSNEDILHVNGFTFTNEKFLNSYVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX47</accession>
    <name>G3AX47_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HRQ family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_91858</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683948.1">
        <property type="nucleotide sequence ID" value="XM_006683885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX47"/>
    <dbReference type="STRING" id="590646.G3AX47"/>
    <dbReference type="GeneID" id="18250120"/>
    <dbReference type="KEGG" id="cten:18250120"/>
    <dbReference type="eggNOG" id="ENOG502QW40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_0_1_1"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV66690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="52916" checksum="0B3549B438FE5A4E" modified="2011-11-16" version="1">MIDTTKLLILALCGVVTSLLLSYKQVGALYRKYGTFYKSYLSFSNPPTPNQSRKSSYSKKDGDPQVAAEPTPLMITPEQVKSYDDRPWRPFRWPYHQTMSIFKLEINHWLDMDKYYWHYIKEKERIWFKYGKENIDWLPEGYEPSLELMETVTDHMLKRYPLCFTLIEDRGKDGKIVKNELTEEVIDMSRPLKEHPLLYVTKMAKEDFYLVMKNPKDDLHYLVAAAVPFPGGSFGINHKIGKHLDVIHNDVPYYHEKLKTSMERWFGRLTPSSPVERASWYMTWDHKLRQNNVYKEPELTEQVKKEALTMDPKDFHVRVERQTLRRLPRTQAIIFTNHPIFYSLDEMKNEPLVPSLIRKIIYEAPEKIIKYKFFEIFRDHIAGYLDELIQRQIDMGLITKETPVKTLPTYPFAHWAEADFDYVNGGFNNPSQKPDHSKEYETSSKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX62</accession>
    <name>G3AX62_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4112 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_100285</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683955.1">
        <property type="nucleotide sequence ID" value="XM_006683892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX62"/>
    <dbReference type="GeneID" id="18245374"/>
    <dbReference type="KEGG" id="cten:18245374"/>
    <dbReference type="eggNOG" id="ENOG502S45T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067862_3_0_1"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24206" checksum="DE1C4B3F65637CE7" modified="2011-11-16" version="1">MSSLLYKYFLKKTNLDSVFTVGGDPNNSDPYFEEIPPNELHFYQKKGARRKRKLPDFIPKHDLNVLDSVKRKAYRLDLQLSMCGLRLGWAGVIGLIPWIGDCISLFFALQLIKKADEIEGGVPIAVKSKMMSNLIFDFIMGLIPLLGDFMNILYKCNSRNFILLEKYLVEKHSPNHHGSKMENMNKKQLQALEDSGMEHGEGPEKTRADDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX94</accession>
    <name>G3AX94_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_132979</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683980.1">
        <property type="nucleotide sequence ID" value="XM_006683917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX94"/>
    <dbReference type="STRING" id="590646.G3AX94"/>
    <dbReference type="GeneID" id="18249661"/>
    <dbReference type="KEGG" id="cten:18249661"/>
    <dbReference type="eggNOG" id="ENOG502QRUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044153_2_0_1"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="377" mass="42248" checksum="0CE276B8AEC79095" modified="2011-11-16" version="1">MTVERINGVFNNQKVELVPIDLPGARTVRGKTYPIGFNIKAEGDDFSSVVEFFRNLGTSGTISKLLNDHGLVILQGLGFTSPKKYSQIVEAIFSTDYELFDQVGLLATREEVEDGVSTVGAQEDAKKHLGKLNAHQEFSRYLHYPAVLTFFSKRAPTLGGGESTTTHATELLDKVYEQFPEVVQTLFEKGATLSQTWGLESPKISWTHPLAFGRYLETGDSLEVQKQKAIKLANERVSNDVEFVDDNLVVHQNNKVVLQHPFNHNPIIFSSLPTYYAGYYNAKKSNLQPNGPGVVFGDGTPIPEDFLDYLFEQSIELEYTHKFVDGDLILLDNYSVYHGRNPYVAGDREILASFWDKKDIVHPGVPESLPELFSEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXH3</accession>
    <name>G3AXH3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-lactate ferricytochrome C oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_100867</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXH3"/>
    <dbReference type="STRING" id="590646.G3AXH3"/>
    <dbReference type="GeneID" id="18245416"/>
    <dbReference type="KEGG" id="cten:18245416"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_3_3_1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="13">
        <location>
            <begin position="120"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV66379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="553" mass="61623" checksum="93E864C82B426325" modified="2011-11-16" version="1">MGSLQSNCKRFNSTVSPKPTSQGVLLKTLIFTTGSVFGAFLYQKEEQRQTLNTNSTLKLSELQPPKYANQTELNQAISEVRQVFKTSTPDLEDESLVVNNSEEERSSHADTYFSSYHPEKHEKPQYIVYPRSTQEVSEVMKIFHKYRVPVVPISGKSSLEGHFVNTRCGVCLDISLMDNVIELNKNDLDMRVQGGVGWETLHDYLDDYNLLFPIDPGPGATISGICSNNASGTNASRYGECYKNILSLTVVLADGTIIKTKHRPRKTSAGYNLNSLFIGSEGTLGIITEATLKLYVKPKIERVAVVPFNSIQDAANAVNSFLLHGMQLNAIELLDDKMMECINKTGETTRKWTEKPTLFLKIGGPNSDVVSSLVDQVKQLSSEQNSTDFQFATSDDETTELWSARKVALWSTINQGKLVDPSIQLWTTDAAVPVSRLPQFLEETKNDIDSHGLQNTLVAHIGDGNAHSFILYKPEQRSVAEEVVDNMVRRAISYEGTCTGEHGIGLGKRQFLLEEVGEDAVDLMRNIKVHVDPLRIMNPDKIFKIDPSEIRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXQ8</accession>
    <name>G3AXQ8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_102388</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXQ8"/>
    <dbReference type="STRING" id="590646.G3AXQ8"/>
    <dbReference type="GeneID" id="18245548"/>
    <dbReference type="KEGG" id="cten:18245548"/>
    <dbReference type="eggNOG" id="ENOG502QQ7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485707_0_0_1"/>
    <dbReference type="OrthoDB" id="2553626at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721:SF1">
        <property type="entry name" value="OS04G0446401 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36721">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="567" mass="61802" checksum="66159652778D611B" modified="2011-11-16" version="1">MDGFDWLKLPQSASSTQKIRPTSPAPPSVSFGGLGPSDSALSSSLRHNASADNVSIPSAKTTRIHSYSDTALVSDDNQASQALADDTGIPLSLTTQDLTLAESRTYIRWYSDILARTETRTISMVDVYKFLHNFKLSAELKDKLNRLFFKILNSINIGEFFALLRLISHCLQGNSLHRGLIRVAAPVPAPPSILSKKRQSGDDEEDDDTLNDSQDPSVPANPTSNPLDLDSFTQFMLTGERPDDKPSKKRSKKLKSVTFSDQIVTDVHESLGPPVPSPAPSPSPQNEIDYSLPMDQLLNRISSQSKNPDAEEQQILDDMGSQLNHFRNLNNVDTASIGGVPSSAPFGHQQYDSQLLRPNMTGPAQMSQYLQKQQQEPQQLRPNVTGPYDMMKIFSPSPDESPQQSVEQPVAQAPRVSLQLFTDQMTGSTAENTLANSRLDATASPNQDRPLPPPPVPAARRARSLSSPTPNGRSVPPPPPPSRRRGVSSTVSSPPPQAFQVPPQAYQVPPQSAPALPPKVIPTEAFYPPPQQQELSAQSSGSTTNILDDLKELQAEVDRIRDMTGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AY13</accession>
    <name>G3AY13_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhomboid-type serine protease 2</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Rhomboid protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_112606</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">cis-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AY13"/>
    <dbReference type="STRING" id="590646.G3AY13"/>
    <dbReference type="eggNOG" id="KOG2632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071084_0_0_1"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="14">
        <location>
            <begin position="61"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV65746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="284" mass="31298" checksum="2F190674B1391D15" modified="2011-11-16" version="1">MSLLNRLTRLIPQDFQLKDYPALTVGLIPFTFLLLLLDSFSNRALSNFFSLDPYAPFRFDLNRVSFYVLYHTGFTHYLVNILAIAAPMCHFERAHGTVHTGITLNLLAVTAGLQYCLLGSFLYPNTRVIGLSGIIFSFVTYFAVKEHEFQPVSFRFPLNGTDISLPTKYSPFVSLAIVTVIFPGSSFFGHLAGISSGYLLAYGKLNILYPPSSIIVAIENKLAGLIKLLDGLVDFVGEQEAINLRYVAYSPIFSSDPETVAISSSTDTTAHTTFRSEGHVLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYA2</accession>
    <name>G3AYA2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_118514</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the NPR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYA2"/>
    <dbReference type="STRING" id="590646.G3AYA2"/>
    <dbReference type="eggNOG" id="ENOG502QW35">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014314_0_0_1"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="6">
        <location>
            <begin position="635"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV65800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="704" mass="80511" checksum="3505753CB86BCCDF" modified="2011-11-16" version="1">MSFNLPNPSLLGLILVISTHNGPQLVFKYPNNLAVKPQDEELENDEYRADDSDSDTESSEDEWDTRHYNFYSGTKKDILSFLDDQDKHRNIKSDKASPKPPRTFQENIGLGIKNLGDSQSNNSKVSIGRPESTTIFGIEQDYLIEMLCPPKEMCNSRFEINIDDYIFSGLPVHCYDNGTWRKKTKIASNTDSTNLDDSVDSPRTTTSMTSFHLVFIAKPPVIESNYRIDEMYHYVVSRLSLVLRHEQSKHDYVWSQVRLISKLKEDFKNQNIFHDLTSFLNDKSSLCKLISDCYNAISSSQIANLSINSKLRSFQIPVKTEFYSIPDSTVPYLPGSHLSSTVNMIGKTGLINVGETARYDIDELNDEDADSSADDIIYLSLLLLDDPERIITDIKAESDSTLASFIRMIKPTETLLRLSHKLKADSSLMSLDISQIKSFAFHLIYWRRARAIPPLNTRSSYIVSPMAPITTNMYEDIAEFKKAFSTMPSLPQFLKLLSSPTKKPRQFATIIPSKDHREIYLDALAWLIRFGYVTKLNTFIWLKVSKKVKIKVEEDMENEALNMNFKTSERKKAVQGTDNTSKVVEKPSLSNVSNPSSYEKDIDDIVMGIKNINQGPEIVLEDDEDTIILDPARANALERRWINKVVTEECKLSPELTVIFFSLLKYMNGKNSLELILLKENIPRNDFRRLLIQIEDHLISVRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYE3</accession>
    <name>G3AYE3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_112694</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYE3"/>
    <dbReference type="HOGENOM" id="CLU_3087048_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="52" mass="5931" checksum="25CA74DB36D8D301" modified="2011-11-16" version="1">MLKSSNSTDEQSAPLVDSTEIKEKNSRLRRDNYKRTVVLFTVMGDLCQPRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYJ2</accession>
    <name>G3AYJ2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92204</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684439.1">
        <property type="nucleotide sequence ID" value="XM_006684376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYJ2"/>
    <dbReference type="GeneID" id="18250170"/>
    <dbReference type="KEGG" id="cten:18250170"/>
    <dbReference type="HOGENOM" id="CLU_818882_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="339" mass="39116" checksum="BEF07A2D08321587" modified="2011-11-16" version="1">MTLKDNMETFYRKRWMSGVQSANNISELNNKIEDDLDLSESHQQSCLTEQLSSSDYYEGIEDDTDSSSRRSNIFESDTDANEDQISNDSVEMRPVMKFNEPDLLIEKLQKDVVKQVRSAMKVPEGNEHILNCSVNAILTDPQFRSVNFADPEGLKKGDEAAFNMILSCQLIDKYVDTKAGELYDIITGSLLFTGEQSGGATVEQPGWFSKYMDIWQFDGQQYDTFDQQTFQDYFMKDLYSSESFETLDVKKIADRIFLMNLQKFRFYFSKMPSKINVCEIDLEELDDDDSKDELEVINKRNLNSFVSQRKSQVTVKFTQDPETIIFEDMDPPESISLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYL3</accession>
    <name>G3AYL3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_92220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684454.1">
        <property type="nucleotide sequence ID" value="XM_006684391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYL3"/>
    <dbReference type="STRING" id="590646.G3AYL3"/>
    <dbReference type="GeneID" id="18250173"/>
    <dbReference type="KEGG" id="cten:18250173"/>
    <dbReference type="eggNOG" id="ENOG502QTEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008472_0_0_1"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="914"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1124" mass="130118" checksum="E5979C07A795DF72" modified="2011-11-16" version="1">MESIQNTQTLTRFLRSKDESLDDILMVIKKLLDNEFDFSFSNYNLFLLELLCDRINDNNKFKNWKFSTQVWKSFSQVWKKMMDIMARDRTFRRVKFLVNLEKIFSQFYEINDTQFYEQLLEVTEMIYSQVVLYADESSCISFLESFLNIYQTDLDDDLLVRWTTLAKKLFKIYRNDINYVASKKSTQKFFHGCLSKLLNNIQNLDDSLNQCRAILISIVEERVFSGDYTVTFQVHFKELLKGKLPESSVGLFYKIIVKNIGNKNPKFCEEVYLAIMEKYNSMSESLIEILSSSNKPLTTSFFESVLDKTLSIGPINWKLVGYIINLDSTLAMDRANNIIDILNVEEDKIVLGFVPTLISSYVKARDLYEFLTQAWLRNVRKRPCWSSTAVIDAVSDNINDLSSTQLVKVIEYVSENDFECYPIVLALVKGLPNCSTLKVDSCEEVLSKSKYVESRTWWDLKFYLLVNYPKMSEYFIDRFNKEDISLNDTHYYLFVFRLSELSGVNLMDEHFSKSFLKHLEHEEQGFCKTLLQRWCVLMNKFFDSKDLQSFINFCIQKLDKTFWVEFLKSNGDIFFEQKNMVLELINVILNSNSIEVFSILSLIPFQCIDRQTRAKLIDKLTDAQFFEPIQNLLTVPTFKSSIETDLNCSIKVLAQGSQVSKDIFSIIWLNNLRQAKSDNKFTSKALSSLKKHIKKRTKEITPEFEATGLVIKYTNVSLLPQEEQESFSELKSKYMNILMSISTKKINSKASTNTIKELLSFLDDVLDSASALISPQFIKMVGKEVNHLNDHQVNSLLFKIATRVWDISNYKHTLSLFLILYKHDDPSLKESLEFYLSRVSDHDDIFSDLILFVLTSMSNSLTSNNSHVFINLCNSMSNNFKKNKRCELSLGVIISLVINKLPILTEASLTPIKKFLSNIRTALTDISWCFTQYSIEQVITIVTKVTYGLNNSNFSQQDVQETYILATQVMAHIILYHRFRLTSRHHMIISVFVALLSPLTLKGGPLKVFPEGSSAFARLLSNLCEPSSNSRNAINKQLTTATSIIKKHLRNFLPVLLVNYISFSLTQNFSRENNNELLPGVFNIFDVLSQRELEIVNSWLDSQGVALYKSLYNDYKAFGKWKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3AYQ2</accession>
    <name>G3AYQ2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAD-superfamily hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_102311</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV65902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684476.1">
        <property type="nucleotide sequence ID" value="XM_006684413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AYQ2"/>
    <dbReference type="STRING" id="590646.G3AYQ2"/>
    <dbReference type="GeneID" id="18245541"/>
    <dbReference type="KEGG" id="cten:18245541"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_3_2_1"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV65902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="64306" checksum="372EB28A7BB119BD" modified="2011-11-16" version="1">MSRDSPDTVSNTSSVTVEKSPGFQSYLNNDGIDELQPTLRKHRVSSLSLSDLNQWQTGLTKLSSTTSLNKSSSQNLRKVDSLAKLSRNSSIIKRKKKAIVDHVRVASYAFCFDIDGVILRGPDTIPQAVKALKLLNGENKYNIKVPYLFVTNGGGKPESARSEDLSRRLDCTITPDQIIQGHTPMKDLVGVYETVLVVGGVGNVCRNVAESYGFKNVYTPLDVMKWNPAVSPYHDLTEDELKCCKDADFSKISIDAILVFADSRNWAADQQIILELLLSKKGVMSTESKTFDEGPSIYFAHSDFIWATNYKLSRYGMGALQVSIAALYREHTGKELKVNRFGKPQKGTFQFANKILTKWRKGVLDEHLKKLSINDPNAEDADILINERGEEIINQQKLESYNYSESESEDDDLELKDLKKQAKKLAVEKSESITLELPPASTVYFVGDTPESDIRFANSHDVSWHSILVKTGVYQEGTVPKYKPKKLVDTVLDAVEYAIEREHEKELLEWNETADDLDDDAKLNFNDLVMTPSDRSREGSKVRPSNSILEHEAVEVPVVLSEEIKKVKDVGISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZ93</accession>
    <name>G3AZ93_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_101276</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996512">
        <property type="protein sequence ID" value="EGV66039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZ93"/>
    <dbReference type="STRING" id="590646.G3AZ93"/>
    <dbReference type="GeneID" id="18245453"/>
    <dbReference type="KEGG" id="cten:18245453"/>
    <dbReference type="eggNOG" id="KOG2769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015750_2_0_1"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="69"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="307"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49648" checksum="A989C55412E5A560" modified="2011-11-16" version="1">MNSNSTKRLREANNTNSSADRHDSKRSKGGLGVEIHPFLKSIVPIPQLPKDFNPLSKSASNAIDSTKSNPYLDSSTPQASRRTRKGAFEFNHSGKYVEIANQIREQEAAKSEQLRKHKILASKGLVPNDDLGESLYSQECPADDTVEWWDAYYVNGDKYRCTEQPENIILDNEEAPVSLYIQHPVFLKAAYEKHMPVQQPLYLTKKEMKRKRKIERQEKLKAQQERVKKGLEPPPPPKVKLSNIMSVLTNEAIKDPTAVEKRVKKEVEARFNKHIQQNEERRLTKEQSHQKLHERREHDLSKGYFRAVYKIQTLVDPQHFFKIDKNAQQLELKGVCIAYNKMSLVVVEGGSKSLKYYDKLITRRIDWTKSNRSDVDLSENRATKVWEGQIKDLQFQKWSVLKPRDDTDLTSMLSRFSLQNYWREALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3AZS1</accession>
    <name>G3AZS1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_97162</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006684912.1">
        <property type="nucleotide sequence ID" value="XM_006684849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AZS1"/>
    <dbReference type="STRING" id="590646.G3AZS1"/>
    <dbReference type="GeneID" id="18250661"/>
    <dbReference type="KEGG" id="cten:18250661"/>
    <dbReference type="eggNOG" id="KOG3943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039352_2_2_1"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="131"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV65226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="258" mass="29605" checksum="4E7B594002866722" modified="2011-11-16" version="1">MGKRKADNGGKRNHKKFKASAIIEPNTTGIYATCTRGKEKGCVKELMNLFTEKAEEYYDLSAVEDDEETDGEEPKELSIEDQIKKEVEDLKDTKSKKSLFSALNLECECLVFIKTKKPIEPELFCKKVCQDSFRSKIKTTRFTQKLTPVTFTVSASIEELKKLCTRVLAPHFHQENDQVPVKFAINVTRRNFNAIEKDVIIKTVAEMVGRDHGHSVDLKNYHKLILIECYKTSIGMSVVDDYEKLCKYNLQQIYEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B023</accession>
    <name>G3B023_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_119496</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B023"/>
    <dbReference type="STRING" id="590646.G3B023"/>
    <dbReference type="GeneID" id="18248703"/>
    <dbReference type="KEGG" id="cten:18248703"/>
    <dbReference type="eggNOG" id="KOG0364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000073">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV65294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="527" mass="58614" checksum="8ADE1A45C9C50D33" modified="2011-11-16" version="1">MQAPVVYMNTSTERQTGREAQISNITAAKAVADIIRTCLGPKAMLKMLLDPMGGIVLTNDGHAILREIDVSHPAAKSMIELSRTQDEEVGDGTTTVIILAGEILAQTFPYIEKKIHPVVIIQALKQALTDALEIIHEVSVPVDIHNDSAMIKLIKASIGTKYISKWSQKMCELSLKAVKTVYIEQGDYKEIDTKRYVRIEKIPGGEVEDSEVLDGILLNKDVTHPKMRRFIENPRIVLLDCPLEYKKGESQTNIEITKEEEWNRILQIEEEQIKILCEQLLEFKPDLVITEKGVSDLAQHYLLKGGVSALRRVKKSDNNRIARATGATIVNRIEDLKESDIGTRCGEFRVDLIGDEYFTFLTKCEDPQACTILLRGASKDILNEIERNLHDAMAVTRNVMFEPSLSPGGGATEMAVSVKLAEKAKSIEGVAQWPYQAVADAFEVIPRTLIQNCGGHPIRILSQLRAKHSSGNHTFGIDGEAGKVVDMNEYGIWEPEVIKHQSIKTAIESACLLLRVDDIVSGVRQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3B075</accession>
    <name>G3B075_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-dehydropantolactone reductase</fullName>
            <ecNumber evidence="6">1.1.1.358</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-dehydropantolactone reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ketopantoyl-lactone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_113054</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16719"/>
            <dbReference type="ChEBI" id="CHEBI:18395"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.358"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>isatin + NADPH + H(+) = 3-hydroxyindolin-2-one + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27539"/>
            <dbReference type="ChEBI" id="CHEBI:28536"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.358" evidence="6"/>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B075"/>
    <dbReference type="STRING" id="590646.G3B075"/>
    <dbReference type="GeneID" id="18246803"/>
    <dbReference type="KEGG" id="cten:18246803"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047011">
        <property type="term" value="F:2-dehydropantolactone reductase (A-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="12">
        <location>
            <begin position="35"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="11">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV65337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="291" mass="32934" checksum="566DB7DA64CB2FA8" modified="2011-11-16" version="1">MTELTTNTQTLLLNDGHRIPQVGFGAMRVPKEGILDALNAGYRLLDTATIYKNEQDVGDAIRQSGIPREQLFVVTKLWNTDHKRVEAALDESLKKLGLEYVDLYLIHWPWSEIEGTDHEVYTDWTFVDTYKALQKVYKTTGKIRSLGVSNFTIAQLEQLSSDKDIDVVPAVNQIEAHPLLTQPKLMAYLESKNILAQAYSPLGGSGNFLFKYKEVTDMASRYGVTPAQLLISWGVQRRTVVIPRSATRSRIESNIRTFTLKDADFEALNTLSDTYGVIRNNDTWRFTPGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0F5</accession>
    <name>G3B0F5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_113110</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0F5"/>
    <dbReference type="STRING" id="590646.G3B0F5"/>
    <dbReference type="GeneID" id="18246827"/>
    <dbReference type="KEGG" id="cten:18246827"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_0_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="219" mass="24591" checksum="42748EEC0D8DE8BB" modified="2011-11-16" version="1">MVDNTDDYSYDYEYLYKIVLIGDSGVGKSNLLSRFTRDEFNLDSRSTIGVEFATRTLEIDGKRVKAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKTESYESVSRWLKELKEHADANIVIELVGNKSDLDHLRAVPTDEAKNFANENSLLFTEASALNSDNVDLSFHQLLKNIYEMISKHQLETDDQPSAKPSSGATISLTPVPQEKKSKNNANCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0Q6</accession>
    <name>G3B0Q6_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_102680</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996514">
        <property type="protein sequence ID" value="EGV65449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0Q6"/>
    <dbReference type="GeneID" id="18245570"/>
    <dbReference type="KEGG" id="cten:18245570"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="520" mass="57445" checksum="F634488490382DCE" modified="2011-11-16" version="1">MKFKFTSLEQIVGPAIAKVLPDHQKPWFQVRHLLKLNLLLLVPLSVSSTAGYDGSLMNGLQSIDPWKAYFNQPHGTMLGFVNAAQNCGCFIMLPLCGWLTDYIGRKFTIAIGLLGVIVATIIQAAAHNLGATIAARFIVGAFGMLAVQPAPLLIAELSYPSYRGKMTSLYWTFYYLGAILASWTCFGTQGRNDNYSWRIPTILQAGFPVLQLVFIWFVPESPRWLISKGKNDKARAILVEHHAGGDEDSELVNVEMSEIVATLEMEGAAKSTKWSDLVSTPGNRRRTYIAVSLGVFAQWNGIAVVSYYLTLVLNTIGITSSTMQTLINGLLQIFNLIAASSAALLVDLLGRRTLFLWSGIGMLVSYIIWTACSAIFAEKGTPGAGKAVVAFIFIFYFHYDIAYTPLLMGYPTEIFPYYLRSKGVAAELMGVYGALIIASFCNSIALDNIGWKYYIVFCVLLVIICLNTYYFYPETKGYSLEEVAQIFDGNEAILDVTSGDLMKHGSAKTSQEHVERVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3B0S1</accession>
    <name>G3B0S1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_113560</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B0S1"/>
    <dbReference type="GeneID" id="18247021"/>
    <dbReference type="KEGG" id="cten:18247021"/>
    <dbReference type="eggNOG" id="KOG4127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2133197_0_0_1"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="113" mass="12484" checksum="57DB6F89429BF809" modified="2011-11-16" version="1">MPKGNESTIDDYVDVVDYVISLIGEDLVGIGSDASEGHGRPSPFMEWCNRDKGYARKMAPWGSQKVVKPLGPLADREELAVAMAKKGWSSTKMEKVLGLNWMAYLETIFDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B150</accession>
    <name>G3B150_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_103610</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B150"/>
    <dbReference type="STRING" id="590646.G3B150"/>
    <dbReference type="eggNOG" id="KOG1197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="334" mass="36594" checksum="8F9CEB5625C32E61" modified="2011-11-16" version="1">MYSFPKSQKAIVLTGTSDTYEVLKYQDVPTPQIESPKGIIIKGKYAAVNFVETYFRKGWNSPQIPLILGRDGAGEIAAVGSEVKDFKVGDKVVYLLKNSYSEYIKTSAEEQRISKLPADTTEKDLELYGSLPAQAITAYIFAEKAGYTPKTGDHVLVWTAAGGVGQVLVQLLNDFGVNVIGLSSTDEKLEFVKSLGAKYTINYKTDDVVSKVKEFTEGKGVNAVYDAVGKASFDTTIASLGQNGVFISYGTSSGAIPPVNLGILTPKNLVFTKPNLFGFLPDRNTWNYYLNKVIYDYKSGRVKYSPVVYDMKDYAKVTELLEAGSTSSKFVLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B171</accession>
    <name>G3B171_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DQD1</name>
        <name evidence="8" type="ORF">CANTEDRAFT_104067</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685701.1">
        <property type="nucleotide sequence ID" value="XM_006685638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B171"/>
    <dbReference type="STRING" id="590646.G3B171"/>
    <dbReference type="GeneID" id="18245679"/>
    <dbReference type="KEGG" id="cten:18245679"/>
    <dbReference type="eggNOG" id="ENOG502S1A9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090968_1_0_1"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF3">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 6">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV64895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="149" mass="16314" checksum="F0F0ECDA89DFE152" modified="2011-11-16" version="1">MVNKVLLINGPNLNLLGTREPEKYGTTSLTDIENAAVKQAQDKSDGSQVLVYQNNTEGFIIDRIQQARLEGVGFIVINAGAYTHTSVGIRDALLATAIPFIEVHITNIHQREPFRHHSYLSDKAIAVVAGLGVYGYTASIAYALNYQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1N7</accession>
    <name>G3B1N7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_104028</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BMT family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1N7"/>
    <dbReference type="STRING" id="590646.G3B1N7"/>
    <dbReference type="GeneID" id="18245672"/>
    <dbReference type="KEGG" id="cten:18245672"/>
    <dbReference type="eggNOG" id="ENOG502QTZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013841_1_1_1"/>
    <dbReference type="OrthoDB" id="3631276at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021988">
        <property type="entry name" value="BMT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12141">
        <property type="entry name" value="BMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV64492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="628" mass="73000" checksum="E56488466BF20977" modified="2011-11-16" version="1">MLNKLLYSKRGHGTVVLLFFCVLASILLVDTLIHDRYLVRKNSESTATGLIPARKNIVYPNTFNLANDRQDLLNHYNIYFNESNAQANSDAFNIFRYDGSTSWLHPQLIGGQYHPHNLQVYEYQEINDCAKRRNDISVEISNYIQLDPELVEMVKVMQRQLKTEKAFEELKPFFKDDLRTQLKTGSLTSHWYKFAGSSVWLEKLGVHMVISRVIYSITGSKRKPIMSLAYVQIYDQYWTELKDVELVLPIQNELSETEYSAVKFPKFLPIPFYNDPKYQKKVYYGPEDTRLFLVKNDQGEEEPMIIFNSYHRKVIKNDGVSEKEMTVSFGFYRSMFLSWPFRMQRGKINVDGVSNKKSDSILYNKVVELRREDVPRLKIQKNWTPMISFEDRDEYGHDRYMYFVYRWSKLEILKCNLDNFIEGTSTCVYDYQRKLDSSGDEVGPLRGGTEMLNIRDILHEVPDALQGREMWVGFPRAHIKDCGCGKDMYRPNLAVITKESDKSYKLTQLSSYTSLDIEVSGWTNPKILCASRDPNALISNGISGWTYHNDVDYLTLSLSVADETNHLIHIKNLLNTLLYSTSMMKREARDGFDDSIIDCAISESSKFCKSYGEEMKKLDKTPPPEPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1P9</accession>
    <name>G3B1P9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sec20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_120022</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1P9"/>
    <dbReference type="STRING" id="590646.G3B1P9"/>
    <dbReference type="GeneID" id="18248748"/>
    <dbReference type="KEGG" id="cten:18248748"/>
    <dbReference type="eggNOG" id="ENOG502S7WD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051527_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="163"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV64501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="336" mass="39021" checksum="BA07C1ECDD36C685" modified="2011-11-16" version="1">MTVPAGIKSYLDELDFLQERVFDKIESITNINESKEASENISIEFTRSKISKEVTKLILQFEELVTVLNAQILNYRDIKEVQVLGEVYKDKLVHLRIDLREAQMESYRQEEEIVHKQRVKKFGTVPERPKTMEEMKHELFEGRSQEEENRLREKSAEDQLVEQNKSITATLQSTRQLMTTSIVQTELNIDSLEQQTKDLSAFDILLNELTSTLRKSGNIVKFIEKQDKQDKYRIYLSIGFLLVCCAWVVWRRILKVPVKILLWSILRIFRVFLWFLPKSTEKDILESVDVSTGISIATATFTASSIDTQSMASEETVVQTWEQIVETATSLIKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1X9</accession>
    <name>G3B1X9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_133866</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1X9"/>
    <dbReference type="STRING" id="590646.G3B1X9"/>
    <dbReference type="GeneID" id="18249747"/>
    <dbReference type="KEGG" id="cten:18249747"/>
    <dbReference type="eggNOG" id="KOG2771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013817_2_0_1"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="202"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV64556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="375" mass="43807" checksum="AE9B40B574FE9DB1" modified="2011-11-16" version="1">MLYKKFFESLVPSSLRSSFRESFRIIENSQKMAKIKDVDHPHIDFEKAVIYGKLKQIKYSKINNVDANIPRLTSVWCCRLKPQQTKAFVKFIRECITPYEPQTFTHIKRLKKIGTGKDFRLDGILCSSSLFTTKDQILELIHEYSDPEISEMTSDQINEVKIPSNIPTTREISLEWSEKFWPMSWRGDPNAQFLKEVKFDIVKEKQMIRKLLDVLETATEEIESKKPTLPVATIVVNPNNEEIVSTSFDCRLAHPLHHSVMLAIEQVAQNEKKSRLQKSAHSVEFDSGYLLNGLVVYTTHEPCVMCSMGLVHSRIKRVIYLQPMKSGGLETNYQLGDRDDLNWNFETWRWLEEEDLKKLHEIERKYKTFDQEVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B1Z3</accession>
    <name>G3B1Z3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sucraseferredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_104484</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B1Z3"/>
    <dbReference type="STRING" id="590646.G3B1Z3"/>
    <dbReference type="eggNOG" id="ENOG502QT0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033921_1_0_1"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV64567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33753" checksum="8DE489142F3C3278" modified="2011-11-16" version="1">MSFFKRFVPSIDKNFQQELEERSFEQSECPIDCGTCHFKYPSSIKVDESSKLWNSSSPYDIHILIPTNKSNWEHNALDDASLPFVQTFNKWVDHNASRISGLPKHNVKVNVCSLSSPGLENDPAYTDGTKGDLLVLPQFVWIRNVDTSDLDAVLPILSNLAEATTKSELHLGQTGGLEVSVDPNQSWIFLCSHRTRDKRCGVTAPIIKKEIDTYTRDLGFYRDFGDERPGGIQVAYVNHVGGHKYVANVLIYLKSSGKMVWLARIGPTNVKPIIDECVLGGGKVWVDNVRLIQKFKPVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>G3B289</accession>
    <name>G3B289_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_113399</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685425.1">
        <property type="nucleotide sequence ID" value="XM_006685362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B289"/>
    <dbReference type="STRING" id="590646.G3B289"/>
    <dbReference type="GeneID" id="18246940"/>
    <dbReference type="KEGG" id="cten:18246940"/>
    <dbReference type="eggNOG" id="KOG1569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_1_1_1"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="263" mass="28813" checksum="25A7216158F7C06E" modified="2011-11-16" version="1">MFNFLKSFGQGTVRSLSTSSILRAPRADPKKQLKKTIKDKRRNKQNPALHPLYMDIPKALRYLRSAEIGEQASKSTISLLITVIPERGSKPLSGLLKLPNPVSSSKILVFSNDPIQMNVDTSSFLMGGTELVGQIADGKVDVSGFTHSYATLDVLPELKSIQRILGPKNLMCMPRKGNVADATELPTLIESNMGTMPFKQTDRHLSFPIARCDFSDKKVLENITEASKTIHSLQPPGTKKPNLIGQTVISSTKGPGIVINFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2H1</accession>
    <name>G3B2H1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1/BLIP-II protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_120507</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2H1"/>
    <dbReference type="STRING" id="590646.G3B2H1"/>
    <dbReference type="GeneID" id="18248783"/>
    <dbReference type="KEGG" id="cten:18248783"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_0_0_1"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="60"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="35800" checksum="BD2BACE307B38374" modified="2011-11-16" version="1">MKLLACGSNGHYQLGNGTNIDTNQLTPASFTVDGHLVDLPSSVAKIATGGNHTFVLLNSGSLYTCGDNSYGQCGLPPADHIAVFTPVPGQWRDVSCGWEYSILVDATDNVFVCGLGLKGELGLGESTTSTVLTRLDAMCGRGISVVSSMSLTLCRASDGKFYGWGDGKKGQLGAKKVRWVPEVVVFPVQEEILHFGLTKTDAVLQLRLRLVSFGRQAIDIPQKVHFFRTMWTCIHYEVEAEPCSVVSVGNNSHGQHFPNSWSQCGGVFETGSEHGLFYANNTVYAWGWGEHGNCGHSQVQGHDQIVFADANAIFKGKPAYMAGGCATSWIATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2H7</accession>
    <name>G3B2H7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein 60S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_97542</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV64677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2H7"/>
    <dbReference type="STRING" id="590646.G3B2H7"/>
    <dbReference type="GeneID" id="18250691"/>
    <dbReference type="KEGG" id="cten:18250691"/>
    <dbReference type="eggNOG" id="KOG3449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_0_1_1"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF103">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442743" description="Ribosomal protein 60S" evidence="6">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV64677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="11725" checksum="93F29A3EEF430DA8" modified="2011-11-16" version="1">MANLSRSMKYIAAYLLLVNAGNASPSAADIKAVLESVSIEVEDEKIEKLLAEVEGKSAEELIAEGNEKLSSVPTGGAAAASSSGAAAASGDAPAEEEAEEEAEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3B2P0</accession>
    <name>G3B2P0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylulose kinase</fullName>
            <ecNumber evidence="6">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_113507</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996515">
        <property type="protein sequence ID" value="EGV65110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006685915.1">
        <property type="nucleotide sequence ID" value="XM_006685852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B2P0"/>
    <dbReference type="STRING" id="590646.G3B2P0"/>
    <dbReference type="GeneID" id="18246995"/>
    <dbReference type="KEGG" id="cten:18246995"/>
    <dbReference type="eggNOG" id="KOG2531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016149_5_0_1"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="7">
        <location>
            <begin position="11"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="8">
        <location>
            <begin position="319"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV65110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="613" mass="68298" checksum="3C4CC4492D6FBAD8" modified="2011-11-16" version="1">MSHTYSDSKELYLGFDLSTQQLKIIVTNESLQVVKLYSVELDHFKDVYHVHKGVVSDETTGEIVSPVAMWLDAIDYVFAEMKADSFPFELVKGISGSAQQHGSVYWSQRASELLASLKPSTLLSEQLVDAFSYPMSPNWQDHSTGHELELFEQVAGGADELAKITGSRAHYRFTGLQIRKIATRKDPKIYASTSRISLVSSFVTSVLLGKIVNIEEADGCGMNLYNLNTNDYNDELLSLAAGVHPKVDKCSEEVTQAGIAELRRKLGPINPITYKADGVISSYFTEKYGFNSNCKIYSFTGDNLATIISLPLNPNDILVSLGTSTTVLLITKNYNPSSQYHLFKHPTIPEHYMGMICYCNGSLARERIRDAINDKYGVPDKKSWDKFNELLDGSKSFNNKLGVYFPLGEIVPNASAQFKRCLLNNNDQIIDASESNWTVDDDASSIVESQTLSCRLRTGPMLANSGDSESSTPTPLENHLHDIYKRTYEKFGDLYTDGKKQNYNSLTARPNNIFYVGGASNNTSIIRKMGSILGANNKNYKVEIPNACALGGAFKASWSLFCENKSELVDFNEYLNGKFNFNELEPFDVENSWEDYFTGAAMLAKMEDGLKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3B300</accession>
    <name>G3B300_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_93558</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686361.1">
        <property type="nucleotide sequence ID" value="XM_006686298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B300"/>
    <dbReference type="STRING" id="590646.G3B300"/>
    <dbReference type="GeneID" id="18250301"/>
    <dbReference type="KEGG" id="cten:18250301"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_0_1_1"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF25">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="197"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV64047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="421" mass="46415" checksum="A09E57D327E837F5" modified="2011-11-16" version="1">MNFPTVNEQESLEFLSKFIQIPSHSKHAAEIDAIKYMTTALQAIELEAQSIEFTDKTDGMLRCNSVGVWKGTGHVSGGRSLLFNGHVDVNPVTEGWTVDPYAGKYDKAETYVQNDNKFIYGIGVSNMKSGCCAYYMAVKTLKDAGWKVSKDVTLTYVVGELQGGAGTVALLEQGKITKETADCFINCEPTDVYGLVMHAGSAIFEINIIGDTRHMSKREEATDAILCSMEAIQKLTYMTFSDPRSSVHESVNRCHVGTIHGGLGRNYESWRAPQVADFVTITGAARYAPGQNEAIVLADLRRELESVQVQHPKMKFELSLVKHDFMPPFEVDPSADIVQTLNRGYKAVRGVDQPTGALKPPCFYGSDAGHLYEKLGMEGIVCGPGGKFNTMPDERVDIVDYLDCIRVFMRVIVETCGGYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B350</accession>
    <name>G3B350_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Serine/threonine-protein kinase rio1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CANTEDRAFT_122167</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B350"/>
    <dbReference type="STRING" id="590646.G3B350"/>
    <dbReference type="GeneID" id="18248885"/>
    <dbReference type="KEGG" id="cten:18248885"/>
    <dbReference type="eggNOG" id="KOG2270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_4_1_1"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000755">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="24">
        <location>
            <begin position="61"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="370"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00068838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EGV64079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="465" mass="53941" checksum="B9883A0EC7649932" modified="2011-11-16" version="1">MQNLEDSTTRLAVYSDSDSDQESTPTGAMPKTLTDNGDIVARYADKINVGFIKKGPKITKDRANRATVEQVLDPRTMRFLAKLINKGVISQINGCISTGKEANVYHADCEDEHGDATKEFAVKIYKTSILVFKDRERYVDGEYRFRNSKGQSNPRKMVKLWAEKEFRNLRRIYSSGIPCPEPVDIRSHVLVMEYLTRGNGEPSPKLKDHDFKDVDEIVHYYHQMLFYMRRLYKVCRLVHADLSEYNSIVHQDKLYIFDVSQSVEHEHPMSLDFLRMDIKNVNDFFSRKKINVYPERLIFKYIIEDNEKLGVIDYSDEELGRYLESVPLKNSQDDELEDEIFRSVYLVRTLNNLDDRDFNNFSTGQIDTLTELVGKKPDSEVHGEDSEDSDSDDSDDSDNDSEGSDEDDSDFSDDGRKKPAKGKKYEDKDDKKQRKEAAKLAKQEKRKTKMKKHIKKKIVNKRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3N0</accession>
    <name>G3B3N0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_114258</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573</strain>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3N0"/>
    <dbReference type="STRING" id="590646.G3B3N0"/>
    <dbReference type="GeneID" id="18247341"/>
    <dbReference type="KEGG" id="cten:18247341"/>
    <dbReference type="eggNOG" id="KOG0862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054453_4_0_1"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000007">
        <property type="entry name" value="SNARE complex subunit SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV64426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="215" mass="24725" checksum="8B0772885A435692" modified="2011-11-16" version="1">MVKSTLIYRYDALPLCGSVDDNNDPALTEQKKKCKIVISRITPNSEPQATIESGAFSIHYLIANSIIYMCICEKSYPRKLAFSYLTEVSTEFDNSHGKSALSQTARPYGFSSFDNFLGKTKKIYQDQRAQSNLDKLNYELADVKKVMTKNIEDLLYRGDSLDKMSDLSNTLRNDSIKYRKKAQQINFEAMLRQYAPIVGVGLFLVFLIWYMFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3W5</accession>
    <name>G3B3W5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_121354</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3W5"/>
    <dbReference type="STRING" id="590646.G3B3W5"/>
    <dbReference type="eggNOG" id="KOG0290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013694_4_0_1"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="55007" checksum="373C9A78B3C8400F" modified="2011-11-16" version="1">MNLGYTPPTPLGYTPQTPLGGTSPVSSPASSAPPISAIPTSFSHAHAPAPPFTTHSSFPSPQGQGFPSQYPPPGLLPPSAGSNLQQPSQTPLSSQNNDSAGLTFPSTDSSISDRYSYYLSTLPLYCSDWGRLPDFSTECIALSSYKEGLSNKLQILHGVAYGKDATTDYNAASFNPGADSGVDTDEAKSIEGFDFYKAAEVSVEYPITNLQWDPAMGSGSHERLAASSEVLRLFKVDHDSLDSNNNFRMSQTHYLTNSTSGATSGGIMNCPPVTSFDWNKLESNLIITASVDTTCTVWDLNRSNPNPDPHQGDSAYVKTQLIAHDSEVFDVKFVTDSTNLFASVGNDGSIRMFDLRSLEHSTIIYEPSSGTGPSRHNYNSKALLKLATSNVDQNYLATIGVNSNQVIVIDTRLPGVPVAVLDGSLGGRNSGAINSIKWHPTGNFLLTGGDDCQALVWDCNNFQLPKDHEHPFVVGSPVLSYEESLEVNNVCWRAPMGDWMGVVSGKGFQAVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B3Z7</accession>
    <name>G3B3Z7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Carboxypeptidase S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_113932</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B3Z7"/>
    <dbReference type="STRING" id="590646.G3B3Z7"/>
    <dbReference type="GeneID" id="18247187"/>
    <dbReference type="KEGG" id="cten:18247187"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000098">
        <property type="entry name" value="Gly-Xaa carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 19" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="18">
        <location>
            <begin position="278"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV64289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="572" mass="63677" checksum="EA67BA7A69E8B1D7" modified="2011-11-16" version="1">MRGLSSSDVKSKKSLIYPIAIAGIVGLSLLSGAILNAFSGKDNLSTDGLCPILPIKAPVSFLKDNSTVLSILHDKEFREKSAEKLAKAVQVDTVVFDSPPEPDENPEYWTKFLKFHQYLRDTFPTVHSTLKLDKVNTYGLVFTWEGTNPDLKPIMLTAHQDVVPVQQDSLGKWTHPPFEGYYDGEYLFGRGSCDCKNVLTAIMESLELLIAQDFKPERTVIAAFGMDEESGGLVGARHIGEFLEERYGVDGIYAIIDEGFPFSLEPQSGVFMATPLVSEKGMATIKSQLQTPGGHSSMPPDHTSIGMISELVYLLENNPFEPLLTSKNPTLNMLQCVATHFGDKLPPSYREAILKADYDTKSNQIVVDALQKDVATRYFIRTSQAVDIIKGGEKANALPEAVTLTVNHRIALESSIKEIVDRFMKYAKIVAVKYNLGLNLEGTPVIDSEGKFGILDVTLDGSKLEPVEPSPSDDTVWEYLAGVSRHLMHDLIKPDLEYDFVVTPMVMQANTDTARYHHLTKSIFRYSPSLGQMINFHSIDERLEFDAHLHLIAFFFEYLQTIDTPDAENQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4E1</accession>
    <name>G3B4E1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_113839</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4E1"/>
    <dbReference type="STRING" id="590646.G3B4E1"/>
    <dbReference type="eggNOG" id="KOG4492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_1_1"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV64250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="378" mass="40772" checksum="7DDE806FBBC062F8" modified="2011-11-16" version="1">MSSFGTLFKVTTYGESHCKSVGCIVEGVPPGLALTEEDIQPQLTRRRPGQSKLSTPRNEKDRVMIQSGTEFGKTLGSPIGMLVLNQDQRPHDYGEMDVFPRPSHADLTYIQKYGLKSSSGGGRASARETIGRVAAGAIAEHILKKINNVEIVAFVSQIGNVAMNRDCNDPTFLKILNTATKDSIDATGPIRCPDENVKDEMVKVIEKHRDSNDSIGGVVTCVIRNCPIGLGEPCFDKLEALLAHAMLSVPATKGFEIGSGFEGVKVPGSKHNDPFTYDENLKRLRTTTNNSGGIQGGISNGENIYFSVAFKSAATISQEQPTSTYDGKDGVLAAKGRHDPSVTPRAVPIVEAMAALVIMDQVLIQNSRTSTIDMLKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4H5</accession>
    <name>G3B4H5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_113860</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4H5"/>
    <dbReference type="STRING" id="590646.G3B4H5"/>
    <dbReference type="GeneID" id="18247150"/>
    <dbReference type="KEGG" id="cten:18247150"/>
    <dbReference type="eggNOG" id="KOG0815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_1_1_1"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV63830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="313" mass="33492" checksum="44DCD87F8517F3C5" modified="2011-11-16" version="1">MGGTREKKAEYFSKLRELLEEYKSIFVVGVDNVSSQQMHEIRKALRSDATVLMGKNTMVRRAIRGFLAELPEYEKLLPFVKGNVGFIFTNADLKTIRDVVTSNVVAAPARAGAVAPFDVWVPAGNTGMEPGKTSFFQALGVPTKIARGTIEIVSDVKVVEANQKVGPSEASLLNMLNISPFTYGMTVVQVYDNGQVFPSDILDITDDELVSHFVSAINVIASISLAVGYPTIPSVGHSVVNHYKNVLALSIATDYTFEGSESIKDRLANPDAYAAAAPAAAAAASGSSDAPAAEEAAEEEEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4K5</accession>
    <name>G3B4K5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_121886</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B4K5"/>
    <dbReference type="GeneID" id="18248871"/>
    <dbReference type="KEGG" id="cten:18248871"/>
    <dbReference type="eggNOG" id="KOG1809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000135_0_0_1"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="7">
        <location>
            <begin position="1904"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="8">
        <location>
            <begin position="2998"/>
            <end position="3102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1527"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1543"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="3128" mass="353656" checksum="AEA3E1112C67CB5B" modified="2011-11-16" version="1">MFESLVANLLNRFLGSYIENFDPKQLNIGIWSGDVKLSNLRLKKDSLDRFNLPINVKFGHLGHLILQIPWSNLKGKPVKIIIEDLYLLASPIIAGEFDLEEEKQKEIRIKLEKLDHLSILENANLQNQEISSDINSNESFTESLVTKIVDNLQVTIKNIHIRYEDDSLLTEDPYSVGLTLKELSAVSVDDSWMPSFISITQALTRKLLTLQNLSCYMNTDSDSIYSEDPNALLSAFKQSLSGNITEEELQYILKPVSGRGKISMNKLGATETTPHIKAELLFDEFGIDLDSQQYEDILWTLSKFHWYIKTHRFRKYRPKVPVSEDPKQWFRYTAKSILNEIHEKNYKWSWEYFAKRRDQRKAYISLYKQKLLEKLTDKNDISELEALDLELPFEDIKFYRSLARGELRKENALNKVKQAQIEKQSDPQQQQAGWFSGWWGATPTEESEKSSEKGQLVDENDFQLNDDQKKALYDAIDYNESEISNIIDLPRDAVKVEILTTLSKGGLSIRTKKNEPNLAEIVFEGCKTRIFQRSDSFLANFEMQEFRIEDGTEPTLYKHVVSVKEYGNKDAKDTTSHSQSDPFFRVSFENNPLDGSADSKLLAKLKSMTIFYNPKLIEEIVKFFQPPKVHLDTVGAIMNAAEATVEGLTSQTRIGLQYALEEHKTINVKLDLQAPLIILPLEPDNWKSPVAILDAGHISVVSKLVEKSKIEEFKAKTTYSEEDWKQLNTLMYDTFILNLQDAQFLVGPNIKDTMSQLHFEDAKDRHSSILDKLNIKLHLGISILPDVYNLARIKVGGEVPAIKLHLNDFQYKAIMQIIDKAIPDFGTSEHDDSSVFNAFSTIEEPQIEDLSASKLEESEALDAPSAKKNHLVEAASAQHMFEFNMKVDEVKVSLSRCIDGVTLRAEPFIDLVGDSLSLDFYTTAANLHLDLVLKDINLFDHIERSGIPEFERLVSSNNFVEHNVDRTKELFKLDYTRSKRLVEFNNKEIEVFDQDIKMDIATVKFVITRKSILSILNFVLNTFTDPNAEATPADELKHNDSENDDFAPQKINVDITLDSIIVVLNEDSVKLATLQLSTAEIELLLLPEAMDIKGRLGALSLHDDINQGSPNDSILRKLFSIEGDNLAEFTYKTFDKETNTNTYNSAIELKTGSSKVYFVESSFKRVFNYLSQFQRMKEIYDSTREAAINQANQINDANRIKFDFSITAPTVVFPTLVHHSNVKYDNLTFELGELYASNIFEKNSKTGSIKNVIKAGLRNINMTSEFNFVNELTQSLELVEGFDLSFDIDYWEEYIEDIPSILINGRLPEVNLKLTELQLKYLLNLSGAVSNVFHTSEIDMEDIQEDAENANAVIKHNIEVLEKVTETKSEFSSSNEARTVSNPKHPKLVFNFDIPKFALTVYNNTSGIEAIDDKMLSSFVLSSLKTQFKMTDDTHFESSISVKSFVVEDVRAENDSCFTEIIPSIKGDRDQFIASIISEGNPEKKNVTVMLTVDNPKVILSLDYLFELQGFIDKVFEKPQTISGLVDDISDDSESESSSAEENTNALRIGQSDSSPSTEGISIGFSINVREPSVMLLADPKKANTEAIIFKIEQILITSQNVLSLAADSVGLFLCTMDNFNDHRLRIIDDFSVSFAHDSRGSNETSFLTNIQASVDPLLVRLSLRDIKLALRIFSKASELYSKAQGKGQENEPETISDNFKRRLSQYAPSFTSTLSGTKRKKVLDSNLDSKVLIKGEELNISLGSMRFVLIGDVHELPVLDMNIKPFDIKAINWSTDLSAETHIESFVNIYNYSRSTWEPLIEPWPISVYATKGGESQPAVIVDVVSRQLAEITITSRSVALLSQIFSLVGEDVELKSREEASPYKIVNQTGYDLEIWNDQQESERKNCTTIKNNESTRWAFEDWREIRENLDTNNKRGILGVKLIGSKYEEIRGISATGEGEEIIMMKPPINGVHNRFIFDITLGQDNVKTIWLRSAVTVQNDADVSVAIKIINEVDSPEIEDVIIKPGDVKSLPIDYVYSSVFKVKPAITTKYEWSTEELYWKDLLYGGSAITCNSSDLNDETSYYFQTEASYDQDEPLARIYPHMNLVISAPVKVVNLLPFDMNYRLYDKGSRKDWSGSIKKGATDFIHVASLRSLLLLSVEPKDFGFKKSDFAIINCSKNSEFKRETTMTLKHESGQMLKLMIYYPRKVEGRTGLRIVIYSPYVILNRTGQNVIISEKSNKLGINGNSSLENVTPKMFSFNNTNVRSNRALMKVGDSQWSVPLSFDAIGQSTECKMQVSGKQTEMNVAITTSEGEGIYNLTKVISIVPRFILKNALKESIQIVENGSTEVTTVEPNELIPLYGLRRNLNKSLMTKFSHGCKSWSSPFAIGDVGQIFLKVFKENVGQMLLKVNILTENGTIFIQIEDAQNNWPFAIRNFSESEFIVYQGNPNVNENGEIVKTDVDYKPIYYRVPPRSIMPYAYDYPKAVIKELILRSHGRERPINLSEIGNLKPFRLPPTQTEDQKIVDLNVIADGPTQSLVISNYDPSLSMYKLQRNQTSSSSVNGSQQNFEANQEDENYNTRIITRFEGFGISLINTKYNELLYMTLRGLEIRYNDSDYYQNLSVKLKWIQIDNQLYGGIFPIVIYPTMIPKSGKEMNNHPSFSASVCKVKDDSHGVIFIKYATILLQEMSIEIDEDFLFALLDFAKIPGASWNKALEDKLCDDTIELPEPKLLSESSDFYFEALHLQPTLTNLSFVRTERVNAEDKVSNSSNTLMFFFNVLTMAIGNVNEAPIKLNALFMENVRVPLPILMESIQTHYGQSFIYQLHKILGSADVLGDPVGLFNNLASGVLDIFYEPYQGFIINDRPQELGIGIAKGGLSFLKKSIFGFSNSVAKFTGSMAKGLSLVTMDERFQERRRLNQRRNKPKHALYGFASGANSFFESVSSGVTGIATAPIEGANSEGALGFFKGFGKGIVGLPTKTAIGIFDLASNVSEGIRSTTTVFDADGLDKVRLPRQIGYDHVIKPYSAREAQGQFWLKSIDGGVYLHENYLAHLVLPGENKTLIVTFKKLILYEINVNKVRWIVSFDQIKSISMESTGIVIGLKKSEGPFIPIPEKSSRAFLYNRIGIAVEDYNKHCQVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4R3</accession>
    <name>G3B4R3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_93359</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV63852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4R3"/>
    <dbReference type="STRING" id="590646.G3B4R3"/>
    <dbReference type="GeneID" id="18250279"/>
    <dbReference type="KEGG" id="cten:18250279"/>
    <dbReference type="eggNOG" id="ENOG502RQ3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219558_0_0_1"/>
    <dbReference type="OrthoDB" id="3981234at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV63852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="227" mass="25431" checksum="08B4F5D7286DF69A" modified="2011-11-16" version="1">MNTNYYLPQFNQQSATPGQQPIHQSQQQHQPHQQHQQNHGSQIQQMQGVQTMPPQSQMIQHAHGQHTNGQVVNAPQSQTSSQPSQPQSANGGYDYQYKQQPMLPQIAVPMNQYYNQPYAQSQNPSASGAVSGTGPGSRFTPKEIHTLKQLLVTGEKYKWKQITKDINFVAARKNHETGGNIKNVSPTFVVRQYQSLLGLPNNQLYFGLLGSSLPYVVHGWDSLEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3B4Z2</accession>
    <name>G3B4Z2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114058</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996521">
        <property type="protein sequence ID" value="EGV64023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B4Z2"/>
    <dbReference type="HOGENOM" id="CLU_2757550_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV64023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="70" mass="7709" checksum="5596BD1E4FA89490" modified="2011-11-16" version="1">MISTHDAKFTSPRELPSSGQNPISNTNSILYRVAPFTSSPLPHHEPPHSDCKSSYSDYSNLKATKHLNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B539</accession>
    <name>G3B539_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_114452</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B539"/>
    <dbReference type="STRING" id="590646.G3B539"/>
    <dbReference type="eggNOG" id="ENOG502S3T7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1111727_0_0_1"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="249" mass="29078" checksum="DC2DE2D77B47E499" modified="2011-11-16" version="1">MKFTFKLPLSGLFKYKVGKFDANLERSIRAKLDTLPSVTKIYANPDGTPRVPSDEEFKTIADLQNMYYKRNHSAWNYIAPGISSEDLNLFKDNSQDLKNFQFVTKDSGKIIDKIPYKDETTGELKWKIVRETEKAEGWEIPYFYIVLPIFSYLAYAKYTAQMKQRELDGPEWAEKELRLRAMEEYFHGDTNKAKEFLSNEGKSPREIQDRDDLVIARILGGDYDKLTDLKKKLPKDLIPKEIEHPVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B547</accession>
    <name>G3B547_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZIP zinc/iron transport family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_114457</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B547"/>
    <dbReference type="STRING" id="590646.G3B547"/>
    <dbReference type="GeneID" id="18247430"/>
    <dbReference type="KEGG" id="cten:18247430"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_0_2_1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV63550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="366" mass="40298" checksum="0B861DBA0894B50C" modified="2011-11-16" version="1">MDSVTELLKRETCATDSDYNGEYMGARISAVFVILVTSTLGALIPVISTKTSVSFLKMPSWLFFGAKYFGTGVIVATAFIHLLQPANENLSNDCLSATFRVYPWAFGIALLSLFSLFFFELLAFNYINKKLESTNGVPHSHSHFGELGKKESDIEDEEEEHENSTPVVSASKGLYPDHFSHAAEHQDPENLDTPLQQMDKEQYYGQLVSTIVLEFGIVFHSVFVGLTLAVSGDEFKTLYVVIVFHQTFEGLGLGTRIAGTRWPKGKEYLPYLFIIAYGLTTPIAIAIGLGVRQSYAPNSQTALIVNGVFDSVSAGILIYTGIVELMAHEFLYSDQFKGPGSFKRMVAAYIVVVFGAGLMALLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B574</accession>
    <name>G3B574_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_114474</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687352.1">
        <property type="nucleotide sequence ID" value="XM_006687289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B574"/>
    <dbReference type="STRING" id="590646.G3B574"/>
    <dbReference type="GeneID" id="18247437"/>
    <dbReference type="KEGG" id="cten:18247437"/>
    <dbReference type="eggNOG" id="KOG4114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138069_1_0_1"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV63558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="113" mass="12801" checksum="956081EC0A074E95" modified="2011-11-16" version="1">MGASCQDQKKALAVCLQRSPCVLIERNTPKDCLTKPELKKDLPALCVANFLSYMECKNGYFDMTKRMRGNAPLSTGKYDQIYDNLSSGNFDAKEEMRKLEVLNRNLSRESPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5A7</accession>
    <name>G3B5A7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">low-specificity L-threonine aldolase</fullName>
            <ecNumber evidence="8">4.1.2.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_114493</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573</strain>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-allo-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:26209"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58585"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:19625"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid degradation; L-threonine degradation via aldolase pathway; acetaldehyde and glycine from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.48" evidence="8"/>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5A7"/>
    <dbReference type="STRING" id="590646.G3B5A7"/>
    <dbReference type="GeneID" id="18247447"/>
    <dbReference type="KEGG" id="cten:18247447"/>
    <dbReference type="eggNOG" id="KOG1368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_1_0_1"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="376" mass="41835" checksum="5603BCD4D6155C45" modified="2011-11-16" version="1">MTVLDTPQYPTHNEFRSDTFTVPTQSMLDSAYHATFGDSVYKEDQSTLDLESYMCQLTGKEAALFCVSGTLSNQVGLRANLYQPPYSVLCDYRSHVYLHEAGGLATLSQAMVHPVVPANGNHLTLDDVLRNYTPDNADIHAAPTKVISLENTLHGIVMPIEHIRQISQFARDNGIKLHLDGARLWNASVETGVSIKEYCSYFDSVSLCLSKSLAAPMGSILVGSRVFVEKANHFKKQNGGGIRQAGMMTAMALTAIKENMPRLHVAHEYARDVGRFCTDHGIKLESPVDTNFVFLDMAANRMSQDRLIAIGHNHNIKIMGNRISFTFQNSQESVDVLKDVILECYKEAQVNPYYGIASNKQLYNYKSVLRSGEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>G3B5M2</accession>
    <name>G3B5M2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_135088</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B5M2"/>
    <dbReference type="STRING" id="590646.G3B5M2"/>
    <dbReference type="eggNOG" id="KOG2328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010510_0_1_1"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV63261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="535" mass="61414" checksum="83E5132FEDA2666F" modified="2011-11-16" version="1">MSETRIRHGKEQNKNIQRAVYEEWLRMVADNKINQKNSWSFGLIDYLYDLSMKPIDNFQRASVILDGCIKIYSSRVDSAATETGTLLSGLSTNFSFEPIVEETAELITEERPLISRKRNVRRESTLVKSFQEIKVKAIETQLMIDPIFKKTLSYFDEGGAKSLLLNILTTDSSGRVIFDSAYPGTNEQVNGNNSYICLNKISMMLIKGRPLESLGICHSIKALKDLIHREDQEVISIPSSDLLYEFSGDEEGYSDNEVCDDNISIEVGLDVQGIPDYELMDYFNNTIKFGATGKESWKVQKYKQNKAHNRVQVSSPKPNRSDLIDFRAYRSFEEEAAFEDEIFQTSSAKISIPVMHRNKGNFSNNHCLIVDEKIDAKNLIELFTKKTRLLPTFNKISPVQLQQKPHENNEEAYTDAYFDEPSRLLNEITREDIEDLHKSYIEEFSQPLSSQISSNLISKLNYEKISKRIDIRHIKDLIMGNLDNGKSFRELTENIPRNLNGSTSVYFICLLHLCNECNLTLEKVSMEDLKIYKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6C4</accession>
    <name>G3B6C4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTEDRAFT_114740</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573</strain>
            <strain evidence="15">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687466.1">
        <property type="nucleotide sequence ID" value="XM_006687403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6C4"/>
    <dbReference type="GeneID" id="18247559"/>
    <dbReference type="KEGG" id="cten:18247559"/>
    <dbReference type="eggNOG" id="KOG0762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_4_1"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="124"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="219"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV63672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="310" mass="34988" checksum="A69B23CB72AABE14" modified="2011-11-16" version="1">MSVAVTDGEDKYLEEVAAAKIHQQTPPPKYLGFVAGTFSGVTKNAVGHPFDTIKVRLQTAPKGQFKGPIDCALQTLRKEGITGFYKGFTPPLVGWVLMDSVMLGSLHIYRRYCKEYLYPKEEKLPLMGHIIAGLGSGWTVSFVAAPIEQFKARLQVQYDAKTKIYNGPVDVVRKLFKTSGIRGLYSGLLSTMIFRTNFIFWWGSYELFTQYFEQNTQMSKPSINFWSGGLSATVFWIFAYPSDVVKQTIMTDSPIRSQKKFPRWIDAAKYIYQENGWRGFTRGFGPSIIRSFPANAAALAAFEAVMRFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6E2</accession>
    <name>G3B6E2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_114753</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573</strain>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6E2"/>
    <dbReference type="STRING" id="590646.G3B6E2"/>
    <dbReference type="eggNOG" id="KOG3494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171977_1_0_1"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV63680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="62" mass="7056" checksum="5866824DC954CEF6" modified="2011-11-16" version="1">MLSALFQRNSVYVATVFGGAFAFEGFFDKAINTWYDNHNKGKLWKDVKGKFLEGGDEDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Q4</accession>
    <name>G3B6Q4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4246 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_114303</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV62988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6Q4"/>
    <dbReference type="STRING" id="590646.G3B6Q4"/>
    <dbReference type="eggNOG" id="ENOG502QQIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2903989_0_0_1"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="62" mass="6825" checksum="FC2C83A1C04FBFFE" modified="2011-11-16" version="1">MVPRVHQGTDPVDGDIFNAEYHAKVIVKLANIELTPENSTYAGGSWHLEGCINEDIVAIVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6V1</accession>
    <name>G3B6V1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_122709</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006686822.1">
        <property type="nucleotide sequence ID" value="XM_006686759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B6V1"/>
    <dbReference type="STRING" id="590646.G3B6V1"/>
    <dbReference type="GeneID" id="18248923"/>
    <dbReference type="KEGG" id="cten:18248923"/>
    <dbReference type="eggNOG" id="ENOG502QSJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045155_1_0_1"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV63029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43811" checksum="F669E7FFF129F7B9" modified="2011-11-16" version="1">MSLFETILNGNTKAMVPESTYDKYLKPTFDKLYKPEYTTTEFDPIKHLRFYSEGPIEQHKYNNTRRLTMEELGLTNPKQISHIGVSDPFPLFTDEAIDIMKQEVLSKDTFMKYGRYSHSSGKGTDCTIRGYAKVNNETVTPFTYAAWTHPRTVELVSTMAGIELEVVMDYEIAHVNVSMKEEDQVEEDLKNYDQTTRDITKDCVVGWHCDSYPFVCVLMLSDTTNMIGGETSLRMGKGTGQDSIAVVPGPTKGYAAVLQGRLIEHIAPNPIGTSERITMVTSYRAKDKKKPDGSVLSTVKPEVNFGSRYNDFYPEWVQYRSDLIIDNLQQLTRDMKKDGIFQKEQVIAELKILEEYLVKTYQEMEVSDEEWSRINESYKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B6Y5</accession>
    <name>G3B6Y5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional activator leucine zipper</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_122760</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="590646.G3B6Y5"/>
    <dbReference type="GeneID" id="18248925"/>
    <dbReference type="KEGG" id="cten:18248925"/>
    <dbReference type="eggNOG" id="KOG1825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000325_0_0_1"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="264"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1419"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1740"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1942"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2435"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2479"/>
            <end position="2507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2435"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2480"/>
            <end position="2489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="2507" mass="283079" checksum="BCCD9A518B013AAE" modified="2011-11-16" version="1">MQTITVDVDDDSLSDENTDTLNDMASPITTRLAPHHPEPSPRLPPPASASSRLTLSNGEEFMNLRRGLATDLKSPAEYTLHIVFTQFVRHAERKLNLCLEYSVHDEAQVIELLAEGNGDDQFDKIIASLGYIAKKKPKPIIDSVMFWRKSKSEVASLAATEVEKVLVNAKSNLGGNGSNSIPNPSPINTNGPKSKRSLSLMRSKSISRIRDHRRNQSASTAAVNKSPVDTTAPSQPVGHSEYAKQKAFYDEQFNQARETAVQAERKSLASIYILCRVLIEVVKQTSPEVMGDDLGVKLEEIVYTQLKTTDPISTSESLLRSANWNLFAELLGCMSEKRFLSVSDRFIADLEKIPTHISHDDEPRLHLLIHGMRYLKLTNYPLEVFEESAEFIESLAKFFKNVQNESLILAYCEVLSNLLLPLANILTAETNHPTWCGAIERIFSKAYFIWNKSNSLSFNSEKGSSGFINLSPNNSSHNGSVANQAASNVWECSLSLLTACLSVSRKELFQTSWYEIIEENMNKLKPKVDIEERTTFIACIDRLLWVFLFRLSDTLNNTIKRLDNLFQLLFFNSAAINKKNQWITADVYLINALVQLIRIVGYRHLNFTLDNIIIELVKQSFNGSTLENLQPEKLILSVKSYMAILADYEIGKRPVFPTDETLKSNNYKDNEKIDFNFIAKNSDNALSHEEIIKNFANLIKLLDTSYGCSIWNKDSSVSPGGNNQPKVQSPFSAFHFGIDFSYQTTKNLHLELFATLIEAAPWTMVPLSSGITFKGIVEILARNSVHSNFRIANASINALRRLASRKNPSSLLNYFAKFAFQFSDKPNPNYDTAYLNSEEFHRLLKLYVELLNCWLRQFKQSSESKQSGNFAHPLSQDDELMSKDVLNDMYQINYKTDDLGVTQSKPKASDELEWKTIITVIEEIEGNGLFFLCSQDHKVRYYGISILKLVDQFDQEIYNATDNTNNPTEANGSTGSAGNGHTQDHSRTSSKFAADFGTRLIHVFEKTDFLDLIKPLKPELSLPERNRVSKLKHKSSILIRLAESDYGIDSTLWFRLYPKLLDIFFEKCPLPVAFCRSIVCVRLVQMHEQILEFSDSYKNYTSSIFSRTNNGVAPEVLVDQWRLYLIFACCSLTSTNEQKISFPSQPTHGRKRSLQMFIQHQKITSAKSVFRMVVPLLKSQQPMVKDSVISSLSCININIFKTLLESVQSPLGEWETNAKRKDPGEDRLRIEIIHILSRVTTRFGPHNLIYSDEWIIANLVSVVKSVKNFLSAGHIQIDIDFQKLRRYFCIFLEKIFIGLEKKSDLDRWLPFEARIGCFNYLKEWCGYGESKDITEERYNLMLEKCNQSKNLPSAAAILEVERKQLSVAALNCMATILSGNITQQIDIPGNVALMSFDVPSLMKWIYSLLSNESESVHDIGKKALSNILRMNPDNDEIYQEVLKQCYTSQDNAKTTESYYITFVHFLMERKQFSKTPSDLLCLATFLIGDDNCEIRKYSMKLLRFVESKFFNSTTVNRFSEAVTSKNKVVYKKALFEISVHLASILPEHNFEQISYFTMCFNVVGNDTRRDILSCLLPWVQTVEVAYNVIPNEVDKLDSDTRLVKPINDLTPASIMVLNNLFEITVKFSSLIMNEVEALWVALGTKPGNFDIIVDYLVSNSLERKSVGFVGYARRIIDYLSYSQPDINIMVDKLIGNLQPKNMVPPRPHSIIDSVRPKKEFPYIANLWELIPYNDKDAAFSLGQLSLIFLVDLFTSDNERMVSQLPLLLHISFSLLDHYLPPVQEAAASLLRHLLHCLALTDPKTEIALNKLGNSDHTKFLWVYDDLNNDKKGARTPKNMDLLVRNCLEIVTPIVANLQEEWSRVALSWATTCAVRHIACRSFQVFRSLLSFLDQPMLKDMLHRLSNTISDETPDIQGFAMQILMTLNAINAELDSEKLIDFPQLFWSGVACLSTIHEQEFIEVLSAMTKFVSKIDLDSPETVSCLISTFPPKWEGRFEGLQQVVMVGLRSATAYDQTMRFLDKLNTLQDSEIIGQGDGRLLMTIVANLPRFLHSLDSKTANPEVETAALVLSGMSERNQKPSLAKIFVSLAKNRFRSKKDFLVQTISSIKAVFFPEYEPQTLVLLLGLLSNKTSWIKLETLSILKYVMPMVELSRDEFVGVGADLISPLLRLLLTDYAEPALEVLDEAVSISGSQLDRDVLRMSLGNSSMKKEYEKTATLFGIPDDSGWAIPMPSVTAASTRNNVHAVFSTCTATSLITEIPQDEEIQFHREDYYAPPTDTASAVDERTEQASLSHMWAALDDFDSFFTKEHDSIPIISPGPRRGDITPAAHLNHLRGGPATHLQHHTHSASIDTGVSTASDSLAPLDSAPFVYDKKASVILNRSLARTRSNASFKTSLADSITPYPRPPTSPLGPKRSYIPFRNSKHQFRSRDTFTTPVMPTSPTFEAVGSPGTITSEVTGDEMMGDTPTMLDTILGSNKKRVRRHGRQSAIPLPEIDSPDSRKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>G3B723</accession>
    <name>G3B723_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_106097</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B723"/>
    <dbReference type="STRING" id="590646.G3B723"/>
    <dbReference type="GeneID" id="18245862"/>
    <dbReference type="KEGG" id="cten:18245862"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV63079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="555" mass="60076" checksum="99DBB93ECA670ABC" modified="2011-11-16" version="1">MSLKLPQAPNAGLFKQGYQSHSSADGAIIRNIEAVREISQIVETSMGPSGRNKIIVNKLGKTFVTNDAATMINELEIVHPAVKILIMASKQQEFEMGDNTNLVIILAGELLNIASKLLSLGLNVSEIIQGYNLACKFVMEKLDSLVINKVESLTDPKELIKVIKSVVSSKQSALEPVISKLIIDAVKLVLNPKKPSAFNVDSIRVVKIMGSSLAHSQVVKGMVFPRQPEGSVKNITSTSKVVVFSCPIDVSTTETSSTVLLHNAQEMLDFSKDEEAQLDQMCKEISDSGVKVIIAGASVGELALHYFNKYGILILKVPSKFDVRRICQVCGATPLPRLGAPTPDEMGEIDVIETKELGGDRVTIFRQGEDSTTRTSTIILRGATQNNLDDVERCIDDGVNSIKGLLKSNELLPGAGGVEIELSKLVTKYGETTPGLLQLAIKQYAKAFEVVPRVLSETSGLDSTEILSKLYAIHSLNDNSGLNIGIDIENDSKDGLINVDNELIYDLLSSKRSAINLATEAANTILSIDQIIMAKRAGGPVMPNKPTPQNWDQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3B727</accession>
    <name>G3B727_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTEDRAFT_93853</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B727"/>
    <dbReference type="STRING" id="590646.G3B727"/>
    <dbReference type="GeneID" id="18250333"/>
    <dbReference type="KEGG" id="cten:18250333"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005472_0_0_1"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="803"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="611"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="751"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="927"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="823"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EGV63081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1047" mass="116692" checksum="AFB3458720630BF6" modified="2011-11-16" version="1">MARFKFGKKKKDGSIDPNTSIDDDSAASIDASQELTPGYDNHLPTPSQGDASGPVYHSPILKKSPLAGATTTSSPPLDPEGTPWTKFKLRNSPFPRYRHSASSISSEKNEVFLMGGLKEGSVFGDTWKIVPTVDPSTNSTIEYTAEPVVIANNNNPPARVGHSSVLIGNAFIIYGGDTVDTDFNGFPDNNFYLFNINNNKYTIPSHILNKPNGRYGHTIGVVSLNNQSSRLYLFGGQLENDVFNDLYYFELNTFKSPKARWNLVEPLNNFRPPPLTNHTMSVYKNQIYVFGGVYNNEKVSNDLWCFDIASSKWTQISSSGNTPLPVNEHSACIIHDKLYVYGGNDFSGIIYNSLYVLDLHTLVWSKLISNGEIDGPGSRCGHTMTYLPALNKILIMGGDKNDYASSDPNDFNTYETKDPAADLDTIIYQLDLSVLDSFLSSRQTVVKATKKAAAAAGLSDTVVRSSTTSPLGSNSATPFGGVATVGAVGTAGVVGAVAATGMGHSSSQEDEVRQGFQRHARSFSAGPEEFRTPAASPERPRDVIDNGDKFVEVPSTAISERGDITEDDIDVSRFSNSGTNDFSNTNGHTKAIETDRLVNSSTPNLAKNVENEKVKQLVAELTSQLTALRQNAKIEMQNATEKINALEHENTALRSTNAEDLKLQLQEKDDVIRELKQQIDPNLLKIDEENEERDVASNITNNSNSVGELTRYKLERLELNNKLIYLTQENSVLNNKIQEFEPFMNNQVAQLSDFQKIIAKQEEKVKILTQQVRDQEILHKEINNWKSKHDNLELEYNNYRSIHDNDDISDDEPEQEDVRSINGVDSTNKSILSNSTTRRSKKDISNQLEHLVNAWNTRNISSASTDRSVNNAVDPMVLELQKQLDGLMKISKEQEVTSAREISTLRSELDVKLSNLRTYDSNYKDALQSVNNTSKALKLTQEELNNQRSLMEKLIKENNELKLFKKASKRTSTRNPLQFPSQENVNIANPIREAENEEDDDALENAHYNMKLKDLEADLFILKQERDQLKDNVTSLQKQLYLAHNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B745</accession>
    <name>G3B745_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_93865</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996524">
        <property type="protein sequence ID" value="EGV63095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B745"/>
    <dbReference type="STRING" id="590646.G3B745"/>
    <dbReference type="GeneID" id="18250335"/>
    <dbReference type="KEGG" id="cten:18250335"/>
    <dbReference type="eggNOG" id="ENOG502QQ4S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024075_0_0_1"/>
    <dbReference type="OrthoDB" id="4055624at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018843">
        <property type="entry name" value="Utp8_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053881">
        <property type="entry name" value="Utp8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10395">
        <property type="entry name" value="Utp8_b_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22542">
        <property type="entry name" value="Utp8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Utp8 beta-propeller" evidence="2">
        <location>
            <begin position="2"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Utp8 C-terminal" evidence="3">
        <location>
            <begin position="352"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV63095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="594" mass="68044" checksum="47621BDA35535174" modified="2011-11-16" version="1">MSFVDFYPILTLPRVSDLPLHSRVIVSPLSSITETNINIAISKSNISSYILYPSPRLVWSYPISPSSVVECMDVKDDSYMIGITDRKTFKLLSLNKGSEESNSIKLKHRIANIKFEEFVWVVLGNGDVLKIDPASLEVIETISNDEQGTHVFSNLDKHILVVTKVSDQLSYKLIHNGVVTHYEAYTDSLFEFNDKHIYRFNKSTKTIEKVDLTFKVQYSVDLSHLLAEGPFSLSVPSEDRVVISDNIKMHLVNLKYESKLAEFQFDDNCDHEILTSIKVKGNSLNTTDTRLFYLKLNSKKNKLNLNLLNLNIEVNTLLANLNKGFKPNENREILQLTNLIDEVYEIKKDTAVHKLVTLYGKDLSKFEIQAIRYLKDQEVKPSHYYSFDSEDKPVDPQAIEKFVSLIFSKENDTLTIKGKVPKFILYYLLSHKLYPSQYTKGLLRLLLSTGNLRLLKQSITFTPGIDVSDLVEVLIYSDNSTVTNDILVRLNDYKVEEVIEMFKTKLSEGENVNGLIKNLIELNNFNSFKLLKNLIDLNGLVSSMRTEVIRKLTELVNYKIRLVELNSLNLNLVNNRIKLADTRVPKYSFEPLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3B799</accession>
    <name>G3B799_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_124493</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B799"/>
    <dbReference type="STRING" id="590646.G3B799"/>
    <dbReference type="GeneID" id="18249029"/>
    <dbReference type="KEGG" id="cten:18249029"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015210_1_1_1"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="563" mass="63416" checksum="202524FF13177CCA" modified="2011-11-16" version="1">MTNEEVAVAPSLSTHQGEDAFTFQRYDHSSNNRKHLSLQPVENGPELDQLIYNYYSIEETIEFIKSKPQCKRVTLQFPDELVCDCSAVAQAISSKLDIEIMKTPSTCGGNSDCSCPNSIDIENDEKQTVWILADTSYSPCCVDEVAAEHVKGDVVIHYGDACLNPVSKVQVAYVFGKPAVNIDETVKEFQKKYEDSSSRVLLMADAPHSYIMHLVYEKLHPIYPNIAFADISQESFPHSTIIGYKPMSSTMDLQLLNRTFHHLVDDEDEELEQLLMSYDLFHISVPEAPRLLKLTTVFQSVTLFDPVEGTTSQGPFPNLMRRYRYMHMARSAGTIGLLVNTLSLSNTKLLLNKLKAKIIEADKKQYMFVVGKPNVAKLSNFEPIDIWCILGCDHQGIIIDQNNEYFKPIITPFELLLALNQELSWNGKWETDFGKLLVQLKQNENENEHEDHNSEDDEPQFNPVTGKFASSSTPLRRPQYLQVETSTTTNTENAQTNALVNRFSSEVVIRDTVSTAAAQLQTRHWTGLGSDYVDDEENAKGALVEDGIKGIARGYEFDVNNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7B9</accession>
    <name>G3B7B9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_115077</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7B9"/>
    <dbReference type="STRING" id="590646.G3B7B9"/>
    <dbReference type="eggNOG" id="KOG0747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_1"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="309" mass="35140" checksum="471DC96014E49B24" modified="2011-11-16" version="1">MTYDKTVLVTGGAGFIGSNLLRSLIHKYPSYFFLCIDKLNYASVDLKTITATNFKFVKLDLTNLPDVKSSLDVHKVTDILNLAAESCVDRSFESPLYFTTNNILSTQNILEYVRVNPHIRLVHVSTDEVYGEQLDTKKVDETGKLNPTNPYSATKASIDLIIRAYEYSFGLKSTIVRPNNVYGPGQYPEKIIPMALHNLKLGNPILLHGDGHHKRSYLYISDFIEALDLIWHSNLYGIYNVGSPHEISNLELIRLILQLSQRKEPIDTYVKFVKDRNYNDSRYLIDYKKLGELGWQASVDLETGLSQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7D5</accession>
    <name>G3B7D5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_95139</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006688417.1">
        <property type="nucleotide sequence ID" value="XM_006688354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7D5"/>
    <dbReference type="STRING" id="590646.G3B7D5"/>
    <dbReference type="GeneID" id="18250481"/>
    <dbReference type="KEGG" id="cten:18250481"/>
    <dbReference type="eggNOG" id="ENOG502T4H3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068304_0_0_1"/>
    <dbReference type="OrthoDB" id="4095418at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442558" description="Nucleotide exchange factor SIL1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV62247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38695" checksum="B664C76C734D7BDA" modified="2011-11-16" version="1">MFLYQIIPFLTLLTAVCCSWVDTLDPQGNLRYEQLVNDLQYITDETIFGRDEVSTSTLDALLISVNNSGIIVDTLYEIASNDDEINSLINVTAGLLNGNTTLDSLPFLQNINISINTSQILDQVMSSGLIQSTAGCLLLDSSNRQILANITGELLRSHTWVGQLLNNLGAGKPLTVNMIADTIQHTPNLNPKYNSSAATANNKQQVLSFDTREVVDDMLSARGDYDGSAEQFLNNIINGVLQSQVFSTSLVSILQSLNNTQILCSTAMEVMQNSTILSMFPKLVGGLYEAGAFNNIDTNYYFQYAKKHAILSDYLQFFLTSPTWEPAIAALLLQMEQNGVFQDIQTGLYGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7U0</accession>
    <name>G3B7U0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115782</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7U0"/>
    <dbReference type="STRING" id="590646.G3B7U0"/>
    <dbReference type="GeneID" id="18248013"/>
    <dbReference type="KEGG" id="cten:18248013"/>
    <dbReference type="eggNOG" id="KOG0658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_20_1"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV62320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="392" mass="45153" checksum="DE2884883FFB715E" modified="2011-11-16" version="1">MLTLTSESSAVRQASTKSEYVTEQVHNCFNDTVSTIHYSDPMMVGHGSFGKVFKTQVSPTNEVIAIKTVLQDPKFKNRELQIMKLIHHPNIVDLKYFFYKSSERHEVYLNLMLEYVPETLYQYIKYYTLKKMPMPLLEIKLYFYQILRAINFINIQGVCHRDIKPQNLLVNPATCELKLCDFGSAKVLKPHEPNVSYACSRYYRAPELIFGNSFYSTKIDVWSIGCVVGEMILGRPLFIGESSIDQLVEIIKVLGTPTRDQIRSMNPTYSEHKFPKIKSISLAKLFKRIPPDLVSLMARVLTYDPSQRLTCIEAMLDPYFDELKVQGARVSTLRNNNAMFPPLFNFSAIELSASPQNNTRLVPEWAHNQLLISLPLQEFRPLNHIEFQIPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3B7W5</accession>
    <name>G3B7W5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phox-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_135611</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687844.1">
        <property type="nucleotide sequence ID" value="XM_006687781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B7W5"/>
    <dbReference type="STRING" id="590646.G3B7W5"/>
    <dbReference type="GeneID" id="18249891"/>
    <dbReference type="KEGG" id="cten:18249891"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033748_1_0_1"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="274"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38768" checksum="1E1130C2C870FBF3" modified="2011-11-16" version="1">MSKVITINSTSVSNNTTYYRIDIKIPLRSLTVSRRYSEFDDLLKTLSQSLGIDSKDFPYKLPAKSSIFTKNSASTISERKQGLEDFLNALVADRELQNIPSLHEFLHLPVMFKFSPSMFKSKDSSIGNLVISDPQSIDSTRWLEFLRLFKSNVNKLMETYNEDPSINNKINIRSKIQSIVKPNMVILAQRLDELYSSGTIEEQEYQRRKLISKELTHEIEGLYDVIEGGSKPSTNVSDFSKRSLLDSRRVIGARPVETKKTIPLNNRELLQHQIQIHRTQDQELEGLRKIIARQKEIGLTINQEVEEQNEMLDSLNDQVELTTDKLRHARNKAKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B883</accession>
    <name>G3B883_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_109342</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B883"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="22"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="527" mass="57835" checksum="8F576C8169700087" modified="2011-11-16" version="1">MSSSHPLQDQSQRLPRRTLFVTLGCLTASLFVSFFDQTAVTTAIPSIAKDLSDSSTISSWVGTSYLIANTNFQLLYGRLSDIFGRKQVFLFSLLCLLVGNLVSGFSNNPIMLFVFRGISGLGGGGINCLVMITFSDLLTTRERGKYFGFVALSTTLGNGIGPLIGGVLSEKASWRWTFWISCPISVVCGLLVICFVPLKPVTGSFKEKLKQLDYLGFFLSLVGTIFVLVAISGGGDNWPWKGAIFITLIVIGSLACIGFLLSEHYLAKIPIIPLHLFNHFQRSYLFLMCFLMGWAYFVDIYYYPLYLQNVRGWSPIMSGVLQLPSTSSSSVFGIIAGFINSKTGHYVRCLYFGGAMWCLGTGLKILFGLHTSPGLLVGANLIQGLGIGFTFQPTLLALLSHSNNHDRAIVTGLRNFFRCFGGSVGLIISGIVFNTIFKSRLRHLNLSDTEIEHIISNPDFSSISNKILSHEVKKAYLHCFKTIMIILTAMSAAMLVLSLMTKDGKEPETEKEAVIESSSDDKTNTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8A5</accession>
    <name>G3B8A5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_115182</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573</strain>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8A5"/>
    <dbReference type="eggNOG" id="ENOG502RQCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2621792_0_0_1"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV62635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="78" mass="9446" checksum="6223F1B8946F666F" modified="2011-11-16" version="1">MRKRKRGPVDDVSESSEADVKRVKNTMAARRYRERQRKDVEILDARIKQLEEELATSRLEVVWWKMEAEKWRSQAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8H8</accession>
    <name>G3B8H8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_126281</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8H8"/>
    <dbReference type="STRING" id="590646.G3B8H8"/>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001040_1_1_1"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000061">
        <property type="entry name" value="Oxysterol binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="262"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="604"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="679"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1102"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV62398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1170" mass="131684" checksum="3E296BC4F8EABF0C" modified="2011-11-16" version="1">MGSPLNASLLRLKLLDALRSGDTAKVDSVNETLLSTKSTTQTKDIIQIKHTILHYSVQVAPLSTIQYLVNNAQQFTVDINSQDQDGNTPLHLAAMTSRGEVVKYLLSLPNINDTTTNLDKKQPVELCKDLTIVQLMQYERAKFVEKSASQLREYFTKRDFKNLERLLVGNPRAAELLDINGADPETGNTVLHEFIAKGDLQMCDWILTHGGDPFKRDKRGKLPIDLIHNKSDPIRKLLKAASRDQTIMDPAMNPTSSKTVSAPTYKGYLKKWTNFASGYKLRYFVLDERGILSYYTNQDDTNNACRGSLNLGFASLHLDSSEKLKFEIIGKNGIRWHLRANHPIETNRWVWNLQNAITYAKDNLKKRGGRQVSSSNGSAPLSPSKRHLLSLRRKHKRTGSHVSLNSLDSKDEDSNSLSRSSTYKKSMDSPNLGKIYEKSTLKAPGGQFDQLSYVETDNENFDFDGDEEDDEDDDDDYYSEDGSMIKTPGNKNLSDEISTVKGSLEVEIRSLLDLFSNVLKSPESLDLEICKVGSNTLGVIQDLFSKYNGLISNKDAKNAKRFDRQLEVNKLWENSIRQLEKEIASREEKLAEFEGKKKQLKKYLTSKSSAGPSTPGSPPVTSALGAGTLASEGSSESRISMINASLNTGVSEQVIENLLNDSDDEFFDADELSESFDEELTEGQKQPESVRAETAVVSESQDAVSIESDTKTLSVDPKTFEENEVPKEQLNGVQQKHKQMVETEGSFLGYENPPRTKLKLDEDDRPKVGLWGILKSMIGKDMTRMTLPVSFNECTSLLQRLIEDVEYSDLLDHAATFEDSSLRTIYVAAFGASEYASTINRIAKPFNPLLGETFEYARPDKNYRVMTEQVSHHPPISACKAESIKWDYYGENAVDSKFRGRSFDFKHLGKMFCVIRPDAGVIDVNGNKVAEELYSWKKVNTSVVGIIVGNPTVDNFGEMEVTNHTTGDKIIVDLKQRGWRASSAYQLSGTVVDKDGNPKWAIGGHWNSKIFGKRLSQTNPNEEQRRASLVSKSDSTNNNFSKDPFSGGAFLIWQAAPRPKIPFNLTAFAVTLNGLDENLKKFVAPTDTRLRPDQRAMEDGQYDKASSEKHRVEEKQRAARKERELKRENYKPLWFVKRKHPVTGDAFWEFKGNYWQSRKEHKMENCPDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8I1</accession>
    <name>G3B8I1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_126291</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8I1"/>
    <dbReference type="STRING" id="590646.G3B8I1"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005724_0_0_1"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="381"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="940"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV62401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123101" checksum="E80B61682661068C" modified="2011-11-16" version="1">MISNSSASNLSLSPNASNDVRTRAKSVSKKHTKELIKKETKQVVSKKLSTILTDLGLQKPIPVKINHTNSSSFSKTVSVYVANSNNCIYLAPASSVSFTYEDVENGGMPQNASGRDDIAGDVPENLSVSVHNDEITPERNSRNLPAELKDKIDMRHSSNYLCTKIDSDTPIPHTFGVVIELHKDAAINAVEFEFASLCNILWPTGDPYNKTYNKERFKIGKLSWMRNLNNADFYVNSSNSSDFKSKKIDPDDLARRTRYYKLKDIKGSTKRKQSQSLDSDSITDSSSASNNDSFSEDGPQMFRAGTYVFVLPILLPEHIPPTITSINGSLNHLLTVSIHKNSEKLNRKLNVQGSFGLPMVRTPPSLANSIADKPIYVNRVWNDALHYIITFPRKYVALGSEHSINVKIVPLVKDVIIKRIKFNVLERITYTSHDMSKEYDFDGEDPYYLRPSLADNKPRERVVSVCELKTKNKQHSGYTEPYKEEIIKCPDNNLLFSCYEPDSNTAIQDNDFENLRVDIAPEPENTMIACPLDINVGLPFLTTRNDKIIQALNNEEELKHLPNYSDPTSRKASIVSSENLSSAPFPPSSPIIGALSTNLTHSHNEENIQHGFTTVGRALYPDSNFRHIQIYHRLQVCFRISKPDPKDNFRMHHYEVVVDTPLILLSSKCNDDSIQLPRYQEIDVIPEDTTHVTKSNISFRTPNFESDTSAYTRNENGEIKGNGFSIKPWNNANVDDTLPTFEEATSPVSSPITRSFSVSEDALSRVPSISIDNDFPSAEPPAYEPGSELTNLDEFSGPLNIDAVVNNRSTSEALAYSRSSRLRTSLVSSFAPPTISFTNSITGTSDNALSVSPTNTSSIPMVHSDSKLSITGSLNPQKLSNSNSLSSFESVGADPVESVSLDSIQDISSVASGVAADTSSTAVTSNSSSRNTEDKSSVMESLSAESNASSSGPLFVERIGAETSVDANEGVGISEETNKVVDRRIEKDSDPDPFPTTPSEPVGDYSTGIHIAEGPDGLVKKKSSPSQKMYQAVNDSEISLDQGYNRLPNDSETNLSIMSHSSTFDQRLPLLRNTSTESNLPLAKQNTVTTHNKLSTDNLSVITEGKQFQDIYHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8L5</accession>
    <name>G3B8L5_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTEDRAFT_124869</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8L5"/>
    <dbReference type="STRING" id="590646.G3B8L5"/>
    <dbReference type="MEROPS" id="S08.070"/>
    <dbReference type="GeneID" id="18249061"/>
    <dbReference type="KEGG" id="cten:18249061"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002976_2_1_1"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442768" description="P/Homo B domain-containing protein" evidence="18">
        <location>
            <begin position="24"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="494"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="659"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="791"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EGV61765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="880" mass="97324" checksum="BD45B8426F8BBB2D" modified="2011-11-16" version="1">MIFRVDLLLVVLHALMSTTGAWASEIPARDYANKNYFMVELDTASSSDPLTAFINQHKDVYQFEHQARGFDDHFVFSIPKGHEHNQFLGNYNSNNHHLMQKRQDFEQEYEMLVTNQNLKSIHMLVPRVLERRAPVPVEPEEYNMARGIIPIDSSQLPIKDAGEKLGINDPIFAQQWHLINTQFPGNDVNVTGLWYEGITGEGVVTSVIDDGLDYEDADLRKNFNKEGSWDFNDNTNLPKPRLFNDYHGTRCAGEIAAVKNNVCGVGVAYDSQVSGIRILSGPLTPEDEAAAMIFGLDINDIYSCSWGPTDDGRTLSAPEKIVKKAMLKGVQEGRENKGSIYVFASGNGGRSDDSCNFDGYTNSIYSITVGAIDYKGLHPLYAEACSAVMVVTYSSGSGEHIHTTDIHGKCSAQHGGTSAAAPLAAGIFSLVLQVNPDLTWRDLQYVAALSSVPVNEKDGHYQTTALGRQYSHKYGYGKVDAYRMAHFGKTWENVKPQSWYYSDVIPVDKTIKIDSSGNGDKDKIISSTLKIGKQELDVMNLERVEHVTVTVNIQSTFRGQVGARLKSPFGVTSDLASFRPHDISSQGFVDWTFSSVAHWGESGVGDWTLEVFNAPDSKGNDIKFVNWQLRLFGESQAAEQAETYDIDKDYAQVRRDRLEKSVAAPVEPSSSSSSSSTSTTELQTFTTSTKAEESVASDDESKEQEGKLPDLVSTTSAAASTTSSATSAPDDTENDSGDGKNAYGNGHSGLYFMALMAIGFIIIAAIMWFHKTPGSSRRRRRREEYEFDIIPGEDYSDSEDVDSHDSFDLGHHNDDNFSLNEERDRLYDDLNGETLPDYHEDEEMFKIGDEEEDAKKPLGKKVNFQDDVTSGSVSAPSPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3B8V4</accession>
    <name>G3B8V4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTEDRAFT_94668</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B8V4"/>
    <dbReference type="STRING" id="590646.G3B8V4"/>
    <dbReference type="GeneID" id="18250423"/>
    <dbReference type="KEGG" id="cten:18250423"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="97"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EGV61781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="487" mass="54900" checksum="3E9274C9104F5E21" modified="2011-11-16" version="1">MSEPQAKDLTHLFSVEAKSRKSSPLKSAFIYYGKPGMTFLGGGLPLAEYFPFETISAKIPKAPFPSGIGSKVSADGYTDITIDKVKGQPNQIELARSLQYGFTEGHTEIMKFVKEHHRSVHGMKYKDWDVIATAGNTESWDSVLRTFTGRGETIFVEEHTFSSALETCNGLGVNTFPVPMDTEGILPDKFEELLNNWVGPIPKLLYTIPTGQNPTGSCLSGDRRKKIYELACKHDFLIIEDEPYFFLQMETYTRDKSTRAGKAVHDHKEFIEALVPSFISMDVEGRVLRLDSFSKVLAPGVRFGWIVGQETLLERIVRLHEVSIQNPSGFTQSLVNGLLYDWGQSGYIDWLIKIREEYTHKRDVCIDAIYDFLPLDYVSFVPPVAGMFFTVYFDASKHPKFEEFDKDVLKIEKSIYEQGLKQGCLMIPGSWFKVEGNSVPPQTDVHSNPATKNLVFFRGTYAAVPLDDLVQGIEKFGKAVRIEYALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9S7</accession>
    <name>G3B9S7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_115413</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573</strain>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9S7"/>
    <dbReference type="STRING" id="590646.G3B9S7"/>
    <dbReference type="GeneID" id="90981657"/>
    <dbReference type="KEGG" id="cten:90981657"/>
    <dbReference type="eggNOG" id="KOG0438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_3_1_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="7">
        <location>
            <begin position="104"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="6">
        <location>
            <begin position="211"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV62722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="362" mass="40568" checksum="387E2932387835BF" modified="2011-11-16" version="1">MIPWRASLRLAQPVRACLTRFQSTVPIPGTVIADKSDLDMTELEKRDEIYKRQRKLIMAQVKLKTYGRGHELPGSTNFKKPIHDHLYKGRPLKELTVPKKNTAGRNHRGKITVRGRGGGHKRRIRLVDSHRLIPGSQTVVRIEYDPNRSGHIALLKHNTSGQLSYILASSGLRAGDQVESFRAGIPEDFINEMKQTNNGEIDEALLNARIIQRGNCLPLKMLPVGSIIHNIGLHPGGRGQMVKSAGTFARLLSKHPEMNKAVVRLASGEHRYVNLDCHATLGTVSNKEHSAIQWGKAGRSRRRGFRPMVRGVAMNAVDHPHGGGRGKSKSNKVSQSMWGLKKFAKTRKFKNVNRFKVRDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3B9V0</accession>
    <name>G3B9V0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_115430</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3B9V0"/>
    <dbReference type="STRING" id="590646.G3B9V0"/>
    <dbReference type="GeneID" id="18247867"/>
    <dbReference type="KEGG" id="cten:18247867"/>
    <dbReference type="eggNOG" id="KOG0373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="314" mass="35930" checksum="0CE4273812D75CD6" modified="2011-11-16" version="1">MSERGPDQWLEQIKKCIALTESDMKQLCELVKELLMEESNIQPVQSPVTVCGDIHGQFHDLLELFRISGGLPSEDNNNNFIFLGDYVDRGYFSLETFTLLMVLKVKYPNRITLVRGNHESRQITQVYGFYEECLTKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFCDLVWSDPENVDTWAVSPRGAGWLFGSKVSREFNHINNLQLIARAHQLVMEGFRYHFKDKDVVTVWSAPNYCYRCGNVASVMKIDEQLDPDFKIFSAVKDGDLAIKTNTNKQNRGDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAF3</accession>
    <name>G3BAF3_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_115504</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV62761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAF3"/>
    <dbReference type="STRING" id="590646.G3BAF3"/>
    <dbReference type="eggNOG" id="KOG2553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021971_0_1_1"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="18">
        <location>
            <begin position="301"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV62761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="559" mass="64687" checksum="8EF76EB09A4BB30F" modified="2011-11-16" version="1">MEDVEVDEQVYKRDQVSKWTRARKEDKRENSNKRQKTEERPDRRSSNNDYQPRVDEEGNVIKSERRPKRKVACMIGYCGTGYNGMQIQNNPDVKTIEGELFQAFINAGAISQENSNDLKKNGFMRAARTDKGVHAAGNVISCKLIIEDEDILQKINKALPEQIRIWGIERTNRSFDCRKMCSSRVYEYLLPTHSFLPPRPGTVLYGQLKEESTANPGFYRDNEEDEKWWKETLAAMDKVKAEVGLKDENVPDADQEKEKLYNEEGQITEFGIKAKKIKQAENTRRRDYKVSNDKLELFRDALKQYEGSHNFHNYTVGKNYKDPSARRYMKSTKVSEPFIIGDTEWVSIKIHGQSFMLHQIRKMIAMAVMLVRTGCPATRINETFSSTRVNIPKAPALGLLLENPVYETYNSMLEKYGYNKIDFSRYQKEMDDFKMKFIYDKIYNEERRENSFHGFFGFIDNFENEEAESLPLTHYFGQVITSSDSALQYSSLHLHTTVVAVIDQHFDTLLASLVAVGLPVDEGYAGPPEEAVVLVEESGEAFELGHSPYLFHHYYRYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BAZ2</accession>
    <name>G3BAZ2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_114957</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996527">
        <property type="protein sequence ID" value="EGV61487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006687657.1">
        <property type="nucleotide sequence ID" value="XM_006687594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BAZ2"/>
    <dbReference type="STRING" id="590646.G3BAZ2"/>
    <dbReference type="GeneID" id="18247652"/>
    <dbReference type="KEGG" id="cten:18247652"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_1_1_1"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="174" mass="18784" checksum="41AC89E403354581" modified="2011-11-16" version="1">MSSDPTDFKLKYVPIDGSNHELTSCKPPVELDLAKEFASGKTVVVTGAPGAFTPTCTEQHIPDYLKHIKDFKAKGVDRVIVLTANDPFVNAAWGKALGYVDDENYFVFASDPEAKFSSKLGGDTYAVDMSKAGMGIRTSRYTSIIKDGSLTFLGNEDTLGFSDISAASTVLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC27</accession>
    <name>G3BC27_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_137241</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689980.1">
        <property type="nucleotide sequence ID" value="XM_006689917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC27"/>
    <dbReference type="GeneID" id="18250042"/>
    <dbReference type="KEGG" id="cten:18250042"/>
    <dbReference type="HOGENOM" id="CLU_1299546_0_0_1"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="212" mass="23771" checksum="C263FF5A7888ADF7" modified="2011-11-16" version="1">MDLKSFRPHSHVNFVDPSDLLVEQEDSQSGQGPQFESQVLNEKDLEPILYSFSYDGYDLDHENLNNSDQKVTQNDFRISTGMYFDVDKNLDDDCEEKKRKKFWFLPFSVDSSLMVDSNLVASNTGNSGGLFNYIPITGETPGEIVYSQSLEPQSTEETDDASTAAAITSQEEFFRQYGDDCDQLHDSSGSSLWAATVVLLAISSLVSYFFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC74</accession>
    <name>G3BC74_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTEDRAFT_111644</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC74"/>
    <dbReference type="STRING" id="590646.G3BC74"/>
    <dbReference type="GeneID" id="18246303"/>
    <dbReference type="KEGG" id="cten:18246303"/>
    <dbReference type="eggNOG" id="KOG2783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022696_0_1_1"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="129"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="337"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EGV60135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="430" mass="49529" checksum="2DF147A025C88B3D" modified="2011-11-16" version="1">MGTTKRTYPDVLEVQGQAFKTDEWTNVPQFILDLTKRQLHQNPNHPIGILRHLIEKNFTGLGYTYYSDFQPVVTTYENFDMLGFPPDHPGRSKSDTYYLNKTHLLRTHTSAHEGECFSLMKTPGYFITADVYRKDEIDRTHYPAFHQMEGARVWDRNQPGLFEQLQRDIDSIPTTNLVVEDCAAQSPANPKQEYMENREVELVSAHLKRTMELLVHTVFEAAKASAAAAGSTEPYLNEPLRVRWVEAYFPWTAPSYEIEVWWKGEWLECCGSGLVRQPVMVNAGLSTDHIGWAFGVGLDRIAMLLFGIPDIRLFWTLDPRFGSQFQQGKVTTFQPYSKFPGIKRDVSFWLPDGSLLHANDVMESIRNYGGDLIESVSLIDEFKHPKTARHSQCYRVNYQSMDRNLTNSEINQIHSDVQNDLIEYFGIEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>G3BC87</accession>
    <name>G3BC87_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTEDRAFT_116164</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573</strain>
            <strain evidence="3">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690243.1">
        <property type="nucleotide sequence ID" value="XM_006690180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BC87"/>
    <dbReference type="STRING" id="590646.G3BC87"/>
    <dbReference type="GeneID" id="18248197"/>
    <dbReference type="KEGG" id="cten:18248197"/>
    <dbReference type="eggNOG" id="ENOG502S4MM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026920_0_0_1"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EGV61028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="420" mass="49036" checksum="F519E5A42DF0B6BE" modified="2011-11-16" version="1">MFGDKEQLSVLEKLQSARVPQTSFPPTHELHKIRASFDYLYVINWLYNFKGYLRLSSEYFDVELFEMELLNLLDPPPLDESVLFINKLKTQIINHLTNSASKFSASDFDMVIKRFFVNTPLGDADTATIFDTLKLSEKFEVLFVILNYLSSLANFRLFLDKTPDVDLSLNAHILKSSDTKNKREDYLLLFNSTKVYKRTIEYPELIVPKKRKDAPEDPEDFFWDQFDVDLAQVSFSVEAWTLDNFNQFIKTHKKNSTFKSLTTNAFQANVVSSEIKKRRIIMNRKKEYQMINLMATRKRSSRIEAKERQKQQDIEDIKAQKEREMRLAIELDKISKPLNYNSNVLSREERLKMRKLNTDYRKDSSQPKSVSPEAVKSETISLTPDIGEAKPNIEEKIEKIEEEIIGHKSTNGEEKPEPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCD4</accession>
    <name>G3BCD4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_100135</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCD4"/>
    <dbReference type="STRING" id="590646.G3BCD4"/>
    <dbReference type="GeneID" id="18245363"/>
    <dbReference type="KEGG" id="cten:18245363"/>
    <dbReference type="eggNOG" id="ENOG502QV53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006329_0_0_1"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV60810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="839" mass="95040" checksum="D6238D9C4D69FF30" modified="2011-11-16" version="1">MVNKPEKEKVTKTPATAAKPKAFTIKYKRPRGSRACVVCRQRKVRCDAEIHIPCTNCITFGCDCELPMVKKRGNGAPDGRKRKEDEIIKTEDDESVEFIKDPSPKAKAHSNSSEPVLNISQVSIPPSLTSKYKNRPSVHKKELMLSKAKASFTFLGSSSVGVIAQNVGDNHVQLNEDVFDVNENSLDSVELEILKIRGAFLLPDRELALDLINSYFEHIHPLMPVVNRTEFMNKFNDPNDNPPLMLLQAVLLCGCRISRNPLLLDSNNSNNLACLTLFRRAKALYETNYESDPIAIVQTLILIGTYWEGPEDVTKNSFYWTRVAIGLAQGFGLHRDVSKSPLSNNEKKIWRRVWWCLFEKDRNVAIAFGRPVVIDLSDCDVPMLTLEDFDENDPESGVVSSYPLNEKQALYFIHLVKLAEITGIILRHQYTVKAESMKKKNKFSIIQHCDMLMGIWFTNLPPQLTFSLNDVSKQDFFSCLLNAQYYNRLYLIHRSNLIRMARSNSTDPNNYKYPSWGISFQAARMIAIISKILYDKDCIYNCPVMFVYIVYSALLMLIYHVDSSNKLISSTASDSLVTLKTVMDQMSEVFPIAKVLLKLFEKYANDRINRAKVIERTGRIAMRQEMSSSKRALENEQNMKAYYGNSNTGGNENLTRDNGNTLNSDFMHTTSSVSSGVSPRAEPFVNRDPTTANFEQMVQEVKRPFQNELHQPQAKNNNQKKNIISPSSSMSFPDISLVTEDMPADSNFFQNFEPTQLFPNMADSRAQSPAISSMINQDDLRDSNDLANDQYMPPPHTPGGTFTTNFIDSTFINMNLQSGADNYIEDEMAGSLFNFQTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCE4</accession>
    <name>G3BCE4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116881</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCE4"/>
    <dbReference type="STRING" id="590646.G3BCE4"/>
    <dbReference type="GeneID" id="18248485"/>
    <dbReference type="KEGG" id="cten:18248485"/>
    <dbReference type="eggNOG" id="KOG1116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013399_0_1_1"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="5">
        <location>
            <begin position="120"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="494" mass="54320" checksum="0A357D89FB322188" modified="2011-11-16" version="1" fragment="single">MSSSSERLLLPQSGTRCRVENTGLVIIDQSLLNPAHSSSYACFPSGASGPTSRTILFEDILWCEQLHETTYAVTYATPIGTNIDTMTFTATIDDVPTAYTPTQSQDLSAHILQRAYGTSIVKPSVLVLINPHGGQGKAKSIYTHRIQPVLEAAKADITVIETLYSKHAMDVARELDIDKYDIIACCSGDGIPHEVINGFYQRPDKGAAAFNKLVVTQLPCGSGNALTLSTHGSNRAAVATFRMLKSEKTQMDLMALTQLDDDGHEQTSLSFLSQCYGAISDSDIGTEHLRWMGPIRFDLGVVQRTLSRAVYPCEVYVKYLTTTKDELVSYFNQCVGQAKETHVITKETLDIKGPKLTESPPSDWIQVDQSLTDNLSIFYVGNMPMVSSNTQFFPAALPNDGSMDMIITDARTSLPKALRALLAIEKGTHVDELFVSHHKVTSYRLVPKLPENSKHYLSVDGEDFPFRAFQVEVLPSVLTTLTSDGNYVPTSFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCK2</accession>
    <name>G3BCK2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116246</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCK2"/>
    <dbReference type="GeneID" id="18248213"/>
    <dbReference type="KEGG" id="cten:18248213"/>
    <dbReference type="eggNOG" id="ENOG502SGGK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_413321_0_0_1"/>
    <dbReference type="OrthoDB" id="4065753at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="624" mass="72398" checksum="4904B37CBB9D64E1" modified="2011-11-16" version="1">MENYETLVEYLNDSESEVSSIAYQSVVLVESDATSAVLMRLYIEQKYREMLAYASVEDVSEWTSQIRLVLALMLFKLGRYKAAMREVAIAADMEVNLLDRRRYLRYEAKLLSILGLKDRLAVCKYAEEYEYQEGVATSTKESSMVPELDETMVTVKVSVPPIHEQALMFISSYGHLPELSLGKVSIMAHKRVADAVAALDHKYSDPLGILYEAAILFAPQYVFKPVAENKHRFAQYLRDQLDKYPEIDVQMDVRQLVKMVGRLERAASSSAASIANLMVKFQFCYGMLHVVSHDYYEASYYFLWTLNFLTLARRQLHPWFNRSEYLSSITIRCCAMMLCQCIEFGKIQFSVFSLENIILKFSMEEVTNPSAEFFSNRAGTQFIAYGVLYEQLAYKQAKKLMVEDTVLLRYEQNQMVEMVRKYVLASILRPQDDPKIVVLLDRAIWGMLMYGGMHLTAVWFFQHLRHYYQLALDFGPLQCSNSLEYTLFSEEHKRYSNMPHVLLRFAELYSQLCETEVKNSWDEGNGDVFLLPLVFASGNRLVLMDKFYDETSLYHDMRNFEFDGFGGLRTKLRSHCKLSHKLIHGRCEVSRDLVRFWIQSYGQYHGSFPPTMVKIVERFGGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCP9</accession>
    <name>G3BCP9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="1">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116910</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690064.1">
        <property type="nucleotide sequence ID" value="XM_006690001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCP9"/>
    <dbReference type="STRING" id="590646.G3BCP9"/>
    <dbReference type="GeneID" id="18248502"/>
    <dbReference type="KEGG" id="cten:18248502"/>
    <dbReference type="eggNOG" id="KOG1560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044094_1_0_1"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="331" mass="37768" checksum="19DDDF32EBF01CB3" modified="2011-11-16" version="1">MASKSKQYQEPTATSIGIDSGALLSLVRHTSENYPSLYSGPLFGFEDDNGSVDISHIYPYPYPDQYEGGSLRSRSGAKYQQEILDSLKTLDYGVEFQGWFQSTLSGSFITSQLVESLAQQQLTNKNAFILVHNMSSIGKELDLKAVRLTRNFVTTYVEGKWKSKDLETNRLSYLNIFEEIPITINNQALVNLYLASETDTPKSTNEFDILNLSSNHNLTAKLLESLSGQIDSYNFDQTNFNYYQRMYSKENLKILQWKQNRRLENLERSKAGQKELDTNEWQSLFKLPAEPSRYNNMLHSSAIDNLADDLLKKCNEELTKSFAIEGKFANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>G3BCZ4</accession>
    <name>G3BCZ4_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_116302</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BCZ4"/>
    <dbReference type="STRING" id="590646.G3BCZ4"/>
    <dbReference type="GeneID" id="18248236"/>
    <dbReference type="KEGG" id="cten:18248236"/>
    <dbReference type="eggNOG" id="KOG0728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="177"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EGV61066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV61067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="401" mass="44785" checksum="17B65211471B2FAE" modified="2011-11-16" version="1">MTVSIDNSYVHEGGIKPYFEQQIQDTEISVQNTTENLRRLEAQRNKLNNKVRQLKDELRLLQEPGSYVGEVIKVMGLNKVLVKIHPEGKYIVNVSKDIDIKKLTPSLRVCLKADSYDLHKILPNKVDPLVSLMMVEKVPDSTYDMVGGLDKQIKEIKEVIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLARSVAHHTECKFIRVSGSELVQKYIGEGSRMVRELFIMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFESSKDIKIIMATNRLDILDPALLRPGRIDRKIEFPAPTVAARADILKIHSRSMNLTRGINLRKIAEKMNGCSGADVKGVCTEAGMYALRERRIHVTQEDFELAVAKVMSKNDEGAVSLAKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDE7</accession>
    <name>G3BDE7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_110518</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006690154.1">
        <property type="nucleotide sequence ID" value="XM_006690091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDE7"/>
    <dbReference type="STRING" id="590646.G3BDE7"/>
    <dbReference type="GeneID" id="18246199"/>
    <dbReference type="KEGG" id="cten:18246199"/>
    <dbReference type="eggNOG" id="ENOG502RQ2U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134522_0_0_1"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="146" mass="17255" checksum="EC8F1060D969723B" modified="2011-11-16" version="1">MVLFSSVKLILISLVALYTSYLYIYKCENVSTLEAILHPINNHHKSLCDYVYKTEEFAKPHLSNAQSFLDKNVHSTEFFQKYQIHEHFVSYSTKAYEFVHPFLIEIYKLVEIVEVYVYDYSVLAWTKAVYFYNTTVVPKIKELTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDK2</accession>
    <name>G3BDK2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_116371</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10573</strain>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDK2"/>
    <dbReference type="STRING" id="590646.G3BDK2"/>
    <dbReference type="eggNOG" id="ENOG502S76V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170555_1_0_1"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV61093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="70" mass="8031" checksum="695CDA87887BA19E" modified="2011-11-16" version="1">MSGYTVLVVFILVAAICSIFWVTAPKQDRTVWRSSVILGISMMFLMWAFTYLSQLHPLVVPIRSDLRPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDS7</accession>
    <name>G3BDS7_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Anion-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_116419</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. Interacts with the chloride channel protein GEF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
        </subcellularLocation>
        <text evidence="11">GET1 and GET2 are required for targeting GET3 to the endoplasmic reticulum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDS7"/>
    <dbReference type="STRING" id="590646.G3BDS7"/>
    <dbReference type="GeneID" id="18248298"/>
    <dbReference type="KEGG" id="cten:18248298"/>
    <dbReference type="eggNOG" id="KOG2825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_0_0_1"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001359">
        <property type="entry name" value="ATPase GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="12">
        <location>
            <begin position="19"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="347" mass="39136" checksum="F812E524B484D742" modified="2011-11-16" version="1">MDFELEPTLESIINQDTLKWVFVGGKGGVGKTTTSSSVAVQLALKYPQDQFLLISTDPAHNLSDAFCQKFNKNATPVEGLPNLSCMEIDPEAAMSDLQQQAAQYNNDPNDPLKSMMSDLTGSIPGIDEALSFMEVLKHIKNQKENAESPDSNTISYKTIIFDTAPTGHTLRFLQLPATLEKLLGKFQDLSGKLGPMMSMLGAGQQQDVFGKLNELQKNVSEVNEQFTNADLTTFVCVCISEFLSLYETERMIQELMSYNMDVNSIVVNQLLFAEDDENCKRCQSRWKMQKKYLDQMSELYEDYHLVKMPLLGTEIRGVENLKRFSKYLLTPYDPKADGHLVYDIEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDT8</accession>
    <name>G3BDT8_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTEDRAFT_116433</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573</strain>
            <strain evidence="10">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDT8"/>
    <dbReference type="STRING" id="590646.G3BDT8"/>
    <dbReference type="GeneID" id="18248302"/>
    <dbReference type="KEGG" id="cten:18248302"/>
    <dbReference type="eggNOG" id="KOG1411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_0_1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="50"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV61118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EGV61119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="431" mass="48092" checksum="0F7FCD984DBD8B5B" modified="2011-11-16" version="1">MLRSSRIATVRPVRAFSLSASFHKWNDIPLAPPDKILGISEAYVKDSNSNKINLGVGAYRNNSGKPIIFPSVKKAELVLLETETEKEYTGITGNKNYQSLVKNFIFNNSGKDAAGEELISSGRIVTAQTISGTGSLRVIADFLNRFYSSKNVIVPKPTWANHVAVLADAGLNPSFYAYYNTEVNGLDFDNLLDSISKAEDESVILLHACCHNPTGMDLTPEQWDQVLELVVKKNLFPMVDMAYQGFASGDPFKDIESIRKLNKLVVEGKIKSYSLCQSFAKNMGLYGERTGSISIITESQEHSKSVESQLKKLIRPMYSSPPIHGSKIVETIMSNPELLQDWLSDLNDVVGRLNAVRTKLYEKLDKSIYNWDHLNQQRGMFIYTGLSKEQVIKLREEYSVYATEDGRFSISGVNDANVDYLADAMNKVIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>G3BDZ4</accession>
    <name>G3BDZ4_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_136902</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BDZ4"/>
    <dbReference type="HOGENOM" id="CLU_1194757_0_0_1"/>
    <dbReference type="OrthoDB" id="4022983at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="232" mass="25832" checksum="807933E3B1E22128" modified="2011-11-16" version="1">MQFLHGFKQEHKQKIISEEYLDYYRSYNNTSVPERISCSMPLSVSLVIAVDHSVFEDDPTLDANVMTQQALRLISLLHGGSFTIVHKLNTTLESDKNNNELGKVIRDCGYPSTPESAPAPFPILEFDNDSKTTALLVPRGWDSWNKITLVSKSIVFDPELSAYTLLTANTNPDAVISAYSNYVNKDTDVSLVCSLFKRNIKPAKNGVSAPSLPEENVLSSFEDLVAVMIDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE04</accession>
    <name>G3BE04_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_116466</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE04"/>
    <dbReference type="STRING" id="590646.G3BE04"/>
    <dbReference type="GeneID" id="18248321"/>
    <dbReference type="KEGG" id="cten:18248321"/>
    <dbReference type="eggNOG" id="KOG1444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025360_1_2_1"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="328" mass="36154" checksum="10BDD72C38EDECBD" modified="2011-11-16" version="1">MEKSSYSGPSSIVNSAPVSIFSYCASSILMTLTNKFVLSGDFNLNFFLLAIQSVTCIVAISTLKSLNIITYRQFNKDEAKKWFPIAALLVAMIYTGSKAIQYLSVPVYTIFKNLTIILIAYGEVLWFGAKVTPMTLGSFFLMVLSSVIAYYGDAKGVPAGDLFELYLGYFWMFVNCFAAAAFVLIMKKRIKLTNFKDFDTTFYNNLLSIPILLVCSFLFEDWSAENVSKNFPAENRTATVMAMLFSGLTSVGISYCSAWCVRVTSSTTYSMVGALNKLPIALSGLIFFEAAVNFFSVSSIFLGFVAGLVYAVAKQKQAKSNTAQQLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE15</accession>
    <name>G3BE15_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_116471</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10573</strain>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV61143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE15"/>
    <dbReference type="STRING" id="590646.G3BE15"/>
    <dbReference type="GeneID" id="18248325"/>
    <dbReference type="KEGG" id="cten:18248325"/>
    <dbReference type="eggNOG" id="KOG3008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_1_0_1"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="39"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="122"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV61142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="299" mass="32405" checksum="D76CBB5743B8BA92" modified="2011-11-16" version="1">MSSPYANLLPANGKWKQQITDFLSEDVPSFDFGGFVVGTKQETAYLYMKQSGLISGIPFAAEVFKQCNLSVQWHYEEAQYITSEELAENKGKIVVAIVTGPANHILLAERTALNLLARSSGIATQSYITKQLADEVGYKGLIAGTRKTTPGLRVLEKYSMLVGGVDTHRYDLSSMVMLKDNHVTSTGSITKAVQSARSVCGFAVKIEVEVSTEEDACEAIDAGADVIMLDNFTGPALQVAAQSLKRKYQGQNKSFLLECSGGLTLQNLGSYLCNDIDIYSTSSIHQGCGIIDFSLKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>G3BE61</accession>
    <name>G3BE61_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_116519</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689679.1">
        <property type="nucleotide sequence ID" value="XM_006689616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BE61"/>
    <dbReference type="GeneID" id="18248342"/>
    <dbReference type="KEGG" id="cten:18248342"/>
    <dbReference type="eggNOG" id="KOG2690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_774258_0_0_1"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV60465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="344" mass="39273" checksum="A8B4687969763BC5" modified="2011-11-16" version="1">MEFVDPVVAQEEVPQVEVSHDEGKTEKAVHQLEDEIDKAYGVVEKKFADLWTSAAKNAGDLQEKYKLEERRNDILKQLNAAKDNIDDRAKVSEHLAQVESQFKSLGEHVKDVNLPEFHIPDIDLKGLSNQANVYLDTLDNTLEQVEKQAGQYVKRFGSFLTGFVSVSNDDANTESTFQGEKETLFASPLSSNSAYGASRYDSDLFKLHTTPESFLNAKDDDRLKTFKVDDKTKEISELLEKYDSTLQVLMNKLVPVQIPYNTFWYRYFILQDELKEQDEARKKLLQAKGKSQEEGADDDEEDFTWDDDDEEEEAVDVASELKKSKEKAKKTAKVSENDGDDDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEA8</accession>
    <name>G3BEA8_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Karyogamy protein KAR4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_110179</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEA8"/>
    <dbReference type="STRING" id="590646.G3BEA8"/>
    <dbReference type="GeneID" id="18246174"/>
    <dbReference type="KEGG" id="cten:18246174"/>
    <dbReference type="eggNOG" id="KOG2097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046318_0_0_1"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV60504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34836" checksum="D4E7B42495CD8D1A" modified="2011-11-16" version="1">MNVKLENDYSNHYIHSGIVPNTYISNIDNPLEGYPKLQKLKELKQKQIEKHQIPPFGCKVKPKDMPAVITNWCTEKNLQFDVVMIGALSTESVLPVLNQLPLAKLCAKPGFLFIWTTEKHILELSVFLNTKLNKKFRRSEELIFIPVNKNSNVFPEQTSDAVFQNQQWHCWMCITGTVRRSSDSHLIHCNVDTDLQFETSNSPVTSHIPDTIYKVAENFSNSNRRLHIIPYSMGYNLFVRSRPGWVIMSPDVLLDNFDPIKYESSLYSKSLINNKGNHVQYLVSQTQEIEELRPKSPNNSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEF9</accession>
    <name>G3BEF9_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTEDRAFT_137016</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10573</strain>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689750.1">
        <property type="nucleotide sequence ID" value="XM_006689687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEF9"/>
    <dbReference type="STRING" id="590646.G3BEF9"/>
    <dbReference type="GeneID" id="18250030"/>
    <dbReference type="KEGG" id="cten:18250030"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007460_0_0_1"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="720"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="1006" mass="115218" checksum="479B847B823027D8" modified="2011-11-16" version="1">MTVTRIRKGLSYVIGESTNNENHILPINSIQYSSLHKKMFTGGRDGVVKVWDSQVSSDAVVPSNGKSKDDDTRPTDMNETLLKLETCISSNVLSHNQLNTSFQVSENHNLHFDWINDMLLINNDDSLVTCSSDLSLKLVNLTPGVPKDSQIHKFANVHTDYVKKLSSCENSNNIISGGLDGKIVIWDLDRLAPVRTIDNDTPGSISRSIYSLSNDNANLISCGGPNNTINIFDKRLESPFIKKLIGHQENVRCMLMDNHYVLSGSSDCTIKLWDLRNYKICKSFDVHEDPIWCLTSTAPDFKTFYSADKVGNIVKTDMTHLNTMSNDFANNALIEKVGLSTLIAKCDTPVMSLCIESDENHNEISLFASTNMSLNRYYVPNTHDLSLYQYLRNYHEFDSHQSTDDLTNEANNDNDINSDFFDLVSHFSIETNLDIQSNFSTPNNISNAGDEVDTSEYASMFFNTSGGGPSMEFVNIDKNNARKPDEYINNIPVEILLNPINPDQITMIPFHKAPIKRYPFTPKSIIAKRLFNNKRSMLVLYLNGDISIWDIFICKKTKTFKFESSSPVEMTSELLKKRLKDMDNIFQEYQTTDTLNNWCEVEIKSGKLFVTLSETTFNNVEVYYDELIDTYPFLSIEYDEDSKKHSRVKITNDDRVQLSRILLNSMFHMYALYEWEFDQVMREELKKKNDIQSPPKEAFNRIKMFSRKSSSTITSMHIASNGNSRPSSNSNSTNVSVHELSLSTKDSVQEFIDSEDVDQYEDSINFLLHDNKAKYLETLTTSKSKVPKTALKFYSNDAKYSRSELSTEESIAYKPLIDLSHLPQDLLIIIFENSPSLGNLRDVFSFRLSELSHLKYAQEDSDQFVNHLRTYLPKWIGQPILYDRFPIKESPKIAFQLLELDYNTLPPEKKINGKAQRKIKRLPVLESSIKLTSHNMLRVSKILGYLTEKFESKTSEMKDKITPTEWLVLECRGQELLPSMTLQTIKSKIWKSSSDIELRFRRKFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>G3BEK9</accession>
    <name>G3BEK9_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_116649</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BEK9"/>
    <dbReference type="STRING" id="590646.G3BEK9"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="GeneID" id="18248387"/>
    <dbReference type="KEGG" id="cten:18248387"/>
    <dbReference type="eggNOG" id="KOG1622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="207"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="235"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV60570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="529" mass="59051" checksum="2137BDBF66D89A8B" modified="2011-11-16" version="1">MSSIEDVPIEVSKVFDTILVLDFGSQYSHLITRRLREFNIYAEMLPCTQKISELSWKPKGVILSGGPYSVYADDAPHVDHDVFKLGVPILGICYGMQELAWINGKGVARGEKREYGPATIDVQDKSCALFKDIDHSQVWMSHHDKLHALPTGYKVVATSGNSPFAAIANDTEQIYGIQFHPEVTHTTQGKTLLRNFAVEICKANTNWSMENFVDTEIARIKKLVGPTAEVIGAVSGGVDSTVGAKILHEAIGERFHAIYVDNGLMRKNETEQVYQTLTEGLGINLTVVDATDKFLDRLKGIKDPEKKRKIIGNTFIHVFEEEAAKIKPASGQEIEYLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLEDMKLKLIEPLRELFKDEVRHLGELLGVPHDLVWRHPFPGPGLAIRVLGEITRPQLKIAREADHIFIEEIKNAGIYKEISQAFAALLPVFSVGVMGDQRTYEQVIALRAIETVDFMTADWYVFEASFLKRVASRIVNEVDGVARVTYDITSKPPATVEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>G3BER7</accession>
    <name>G3BER7_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Cap-associated protein CAF20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTEDRAFT_111701</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CAF20 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BER7"/>
    <dbReference type="STRING" id="590646.G3BER7"/>
    <dbReference type="GeneID" id="18246308"/>
    <dbReference type="KEGG" id="cten:18246308"/>
    <dbReference type="eggNOG" id="ENOG502S2E7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128343_0_0_1"/>
    <dbReference type="OrthoDB" id="3995390at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031456">
        <property type="entry name" value="Caf20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17052">
        <property type="entry name" value="CAF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EGV60576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="159" mass="18267" checksum="C053F16717F26B7E" modified="2011-11-16" version="1">MVKYTEEQLIEIKPEAYTPQPEILDEFNKLVESVTLEFAEKGARRNHNGDSFIDEHGNERTYNYLNRRRGSRSGARPLKKKAQEVEVDDDGWATLTKHKKSFSDEAVDERDQFREAVRSEPTKVKISNKKMGSSKAVDSRDTVADKHTNTFNAFEALDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF42</accession>
    <name>G3BF42_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ribosomal subunit protein uS4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTEDRAFT_116698</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF42"/>
    <dbReference type="STRING" id="590646.G3BF42"/>
    <dbReference type="GeneID" id="18248407"/>
    <dbReference type="KEGG" id="cten:18248407"/>
    <dbReference type="eggNOG" id="ENOG502QTS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026386_0_0_1"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000025">
        <property type="entry name" value="30S ribosomal subunit S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EGV60630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="463" mass="52813" checksum="D2571ADE5084A38F" modified="2011-11-16" version="1">MPRRTQNMNSLSRGRVRSSMNKYNLFNLYKKPALTSRAKTLFQQKWTSKAETRAYHGEHLTESRWKTIFDPNLQSVAQLDASLKGLGVKPTPMALQTYAVLEKRLEFAVFRSMFASSIRQARQFILGGHVQVNGVTIKHPSFPLQSGDVFNVKPEKVLLAMGRVKPSLDQAIKTDNKQIVVWNKYVKAAKENPKEVWELKVSKPESLDPSNKIDIKASVKAHNKKLEQQMKFKQNQTTRPFVLSQILAKGNKQEVTDTAVFKSLYGEKNATKCLQAYKLLFDSKHPLVENFGAEQCESYVNKKSNEFDDAKEFKLVSSVKQILSELVKTHQEFLRVEANENKLPEDSTHIPYSPAFGSNLKFHDKLDVEKVKENEASAKVSLPWQSSLFGRIDPSKPYFTPWTPRPFIGCFAILPSHIEISFSTCHAIYLRDPVARPGHSEVISPFPSDIHERAYMFYARKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>G3BF58</accession>
    <name>G3BF58_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTEDRAFT_96092</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BF58"/>
    <dbReference type="STRING" id="590646.G3BF58"/>
    <dbReference type="GeneID" id="18250578"/>
    <dbReference type="KEGG" id="cten:18250578"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009308_0_0_1"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EGV60644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="706" mass="82518" checksum="32404D7DA70B319D" modified="2011-11-16" version="1">MKFGEHLRKSLIKDYSYYYIDYDDLKHELKKSLKSNDFQWKNQLEEEFLNMLEIELDKVYSFTKVKNTELKRRIKDAEKRVNTVIKNLNTTEDDEFQSLENELSDVIADVHDLARFTRLNYTGFQKIVKKHDKLTKFNLRPIFSVRLDAKPFFKDNYDPLIVKLSKLYDLVRTKGNPIKGDSSAGGSQQNFVRQTTKYWVHPDNITELKLIILKHLPVLVFNAEKEFEPEDGAITSIYFDNKDMDLYYGRLMKDEGAEAIRLRWYGGMKSEQIFVERKTHREDWTGEKSVKARFVLKEKKVNAFLKGGLTAKQVFDKMRKEGKKSEQQIENLEKLATEVQYRVIKDKFRPVMRSFYNRTAFQLPGDARVRISLDTELSMVREDNFDGHDRTDGNWRRMDIGVDYPFSQLPEKDICRFPYAVLEVKLQTQLGQEPPLWIRELIGSHLVEAVPKFSKFIHGGASLLPDYVTYLPFWLPQMDVDIRKPKILEEFGINRNQYRLKTSSSGNELDEEEGAGREVTFSNDVNPLEDDLDETTPLLFPSSYMSSSTGTPFQQWFVKVYGKFLHYFNDDRTFNVKPGTNFDLNTTFKDKIPKGKEIAIPIRIEPKVYFAAERTFLSWLSIGMILSITATTLLNYGTKTSLTASIGFFVTALFTFVYSTFMYIWRTLMIREKRPAKYGDTFGPNMICFFIALSTFLTFVFKFTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFB1</accession>
    <name>G3BFB1_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BOP1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_116033</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFB1"/>
    <dbReference type="STRING" id="590646.G3BFB1"/>
    <dbReference type="eggNOG" id="KOG0650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2365199_0_0_1"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="96" mass="11589" checksum="583B42005A01F321" modified="2011-11-16" version="1" fragment="single">MKIVRAIREGRIIPPSKVKEMKEQEEEAKQFDLWEDEVEVQDHIMNLRAPKMLPPSHEESYNPPEEYLFTEEELKQWEENPEERTTNFVPQKYTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFF6</accession>
    <name>G3BFF6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM7</name>
        <name evidence="6" type="ORF">CANTEDRAFT_111326</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689893.1">
        <property type="nucleotide sequence ID" value="XM_006689830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFF6"/>
    <dbReference type="STRING" id="590646.G3BFF6"/>
    <dbReference type="GeneID" id="18246268"/>
    <dbReference type="KEGG" id="cten:18246268"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032409_0_0_1"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EGV60679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="258" mass="29702" checksum="80E4309CBD59C3B1" modified="2011-11-16" version="1">MSEEEEILDLGMFEEPADFRPPAAEHHFALYERVTTKAPSTINLRLVGKSPLWGHLLWNAGKYTANYIDEHAEELVRGKRILELGAAAALPSLICGLNGASEVICTDYPDPDLIENIQYNVDHCQELSPQAVKVRGYIWGGEKAGIYGVEEKKMVLEDEKFDLIILSDLVFNHTEHLKLLQDCRDLLKRDGKVFVVFSPHRPRLLSNDLEFFKTAEQYEFKSVQNDLVIWKPMFEEDDETAEIRARVYSYFLIPQWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFM0</accession>
    <name>G3BFM0_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_95516</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689265.1">
        <property type="nucleotide sequence ID" value="XM_006689202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFM0"/>
    <dbReference type="GeneID" id="18250511"/>
    <dbReference type="KEGG" id="cten:18250511"/>
    <dbReference type="eggNOG" id="ENOG502T6DQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_454134_0_0_1"/>
    <dbReference type="OrthoDB" id="4093184at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="601" mass="67935" checksum="EF28A544FD22C3B5" modified="2011-11-16" version="1">MNLTFESDSEVRAQVDTYAAQVRYAVSQEFQIDELLDSCVSVDQVWDALDTAKHRLYSVVSTVQVVPVHGNVVTWTAVVAEVLLSVCKLRVLLEDAVLKYGSSAERIRLKMGQVYVDTNEFVLRCVSDRIYGERAVAIAREHAAFALELSRMLVNVFEVSEYNLAVDCGSISNYQLLLKQGTGITANLFEGVLERPWKGQCLGLVFGTLVRCLKAIYTTGNSKTLETLLTVISPTLVSEIRKFAKVEYRDIVDYYKYVAFNFVWLAVEDLSCIDDDYTHQADIYFNCLLALPSSDYSVIPSLEKQPSNGLEANSYDPRIRRLYQEQVSSEREIDCDQVMMRYNERHEISLMFVLNSMLMVQRLEEAVSVPPLLVEEMEVFSKSLADHLTSSIRKQSTSGLNSAPRVRALKGGSTATPVPELHEASKFQCLSSIITNGSYKARHIAVLKWLQHLKRGKLNTLINIFSINESNPTSFSTLVQSCDPSKYPGVHHFYQVLITVSRLFELLKLKFFVASTGSSVIGESDLQRLISDTSDLHAILKVKKLLDCKLQVREGQNLYCFSLVQSDKREQNTVESHQTELVRSINELEEQIDNDLFEPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFP1</accession>
    <name>G3BFP1_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_116094</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006689280.1">
        <property type="nucleotide sequence ID" value="XM_006689217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFP1"/>
    <dbReference type="GeneID" id="18248165"/>
    <dbReference type="KEGG" id="cten:18248165"/>
    <dbReference type="eggNOG" id="ENOG502SB1Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_706188_0_0_1"/>
    <dbReference type="OrthoDB" id="4089405at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV60066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="374" mass="42242" checksum="0DFDC27594EE1AE3" modified="2011-11-16" version="1">MFAKPILRIGLSRTAVRRIHTIDALEARVNTWKEPVPPAEVLALIDEYHRLQVQVYDYNKFWNNPTNKRINHQITQVLQNPHVTFDKTLLAQLFRMKLPSLTNINIIGVFYERSPTAYIDKAIALVPFRQSLFNGDLQSALKLTDITVGHPNYTAHKHSELKTGVVKLVGSGVGITVFSKYGVQELIDSGILGDAWRYLGSVNTLVVTYLLNSSFLMTIVKFGRQLISSGGDYLTWQKGTFYSHWYKHADEMMFCSKIVEADLRLNGGGVSGGEVSSDLATELCRTGDNDTSLAPGYTRDGHKVRLLDLRDNLEELKLQAYWMSGGDGFEWVEPDQDPAELIWKRHLKKFEELGAGDEGKALKWADQVIEPEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>G3BFV6</accession>
    <name>G3BFV6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_132431</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="GL996528">
        <property type="protein sequence ID" value="EGV60740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3BFV6"/>
    <dbReference type="STRING" id="590646.G3BFV6"/>
    <dbReference type="GeneID" id="18249621"/>
    <dbReference type="KEGG" id="cten:18249621"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006451_1_1_1"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV60740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="828" mass="95095" checksum="07C350506484D6E6" modified="2011-11-16" version="1">MSDSQHKRTHSSSSEFDPFEDPEDYYSNKNVSMNRARTFSVFESSSTKFSPYSDDPISERSHENTPTPSDSLSSTPAPEVSDKNVPVPMLQSDSSGSSRSEESSNFAKRPSIVPVYDESFSSTSELTKTEEEVKEVNERIKQLHLRRSSWDDNMYRRPKKFYIPDVDTTLTQLLNNEDTDHNCQITIEDTGPKVLKLGTANSNGYKQFDIRGTYMLSNLLQELTIAKRLGKKHLVLDEQRLSENPVFRMKRLISTQFWKNLTRQMTKNTIMEMAKDTKIPEEYINEKGEKVAARETHRIYVPHNRADQFEYFMSIKKTNTDANLDVQYLPEVIDAKFIRSINKKPGLLALQSRPDPNDPNNLINEPYVVPGGRFNELYGWDSYMESLGLLVDVTPTNTTNLDLAKGMTENFIYEINHYGKVLNANRSYYLGRSQPPFLTDMALRVFNKLMEVRPEATEESLKFLERAVKAAIIEYKTIWTAKPRYDDATGLSCYHPEGLGVPPETESSHFVEVLKPYTEKYNVSHEEFIELYNSEKIKEPALDEYFLHDRAVRESGHDTSYRLEGKCAYLATVDLNSLLYKYEVDIAFMVETYFHNSLQVNGVVETKSSWLERATIRKQNITKYLWNEKDGIFYDYHIKNHTQTGYESATTFWPLWSKAASPEQASRLVKQSLHKFEEFGGLVAGTEASRGAVNLSRPSRQWDYPYGWAPQQILAWIGLANYGFDGDARRLIYRWLYLMTKAFADYNGVVVEKYNVVKGATPHKVDAEYGNQGADFKGVATEGFGWVNASYMFGLTFLNVHAIRNIGALMPPDVFLANMHPDQRQLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW88</accession>
    <name>G3AW88_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTEDRAFT_132736</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW88"/>
    <dbReference type="STRING" id="590646.G3AW88"/>
    <dbReference type="eggNOG" id="ENOG502S90A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035824_0_0_1"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018571">
        <property type="entry name" value="Membrane_anchor_Opy2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09463">
        <property type="entry name" value="Opy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="3">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EGV66484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="495" mass="53013" checksum="D3F183E16484AB61" modified="2011-11-16" version="1">MSVSPEVIARDAGQAGAEATATAFIIAANRAVRPTSTTGQQYPSPVRVFPRAASSSYSTDSHGCVVCPSTTPTGPTCGSNQERLLSAQSCSSCPKYYCSDLDDSGSKGPNIGGIVGGVVGGVAAVIASGLMYYFFVWKKRHPSLEDDEEIYMEDLDLDESKDAMSSESAGNSNPDKRYSGGLETTERPGGGAGGAGRRANLANRRLSSYESFTRPQAKFKSRRGQASASRRASQRLMSRNLTAASPYLDANSSRRNSVATTISTTNASNILPIAYIPGVTVRPTKNNTKSIYSYETDSIFSDLNTIENASIIGDIMRANYSEEPKQDNTMTAIKAQPRLISVDRIEEEDEDEEEFDDDYDGVDVDVDDSVNNSVSKNNSKTSIVTSTRQLNESTVSNVTSQIAEEDEGQNYSSDSDGDSDVDSDLGEIQRATSVRRNNHTEMALDLIDLGQPGARAGDDATARSDGGSFVLDVEIDHNGRSPSQTSGEKSPFEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW91</accession>
    <name>G3AW91_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_96524</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW91"/>
    <dbReference type="STRING" id="590646.G3AW91"/>
    <dbReference type="GeneID" id="18250614"/>
    <dbReference type="KEGG" id="cten:18250614"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="16"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="348" mass="36639" checksum="B12C77E733990F13" modified="2011-11-16" version="1">MSIPKTQKAVIFETNGGPLKYADIQVPKPKANELLINVKYSGVCHTDLHAWKGDWPLATKLPLVGGHEGAGVVVGMGENVVGWEIGDYAGIKWLNGSCLSCEFCNTSNESNCADADLSGYTHDGSFQQYATADAVQAARIPKGVDLAQVAPILCAGITVYKALKTANLAAGQWVAISGAGGGLGSLAIQYAKAMGYRVLGIDGGEEKGEFVKSLGAEYYVDFTKSKDVAKEIIKVTNGGPHGVINVSVSEAAISQSCQYVRSLGTVVLVGLPAGAKVTAPVFESVVKSISIRGSYVGNRADTAEAIDFFTRGLIKCPIKIAGLSELPKIYELMEQGKIIGRYVVDTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>G3AW94</accession>
    <name>G3AW94_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTEDRAFT_112205</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AW94"/>
    <dbReference type="STRING" id="590646.G3AW94"/>
    <dbReference type="GeneID" id="18246400"/>
    <dbReference type="KEGG" id="cten:18246400"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_3_2_1"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="413"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EGV66490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="507" mass="57427" checksum="732F10096BE4E3BD" modified="2011-11-16" version="1">MSGSEKLEIADLTALNAIAAGSNKKNPRIVAAGIGGKLMGTKSLVTVTAEQLTEDLKHNNSLSQEQKNKIIQDVKDAKVANEVKKTEDATKLHISEQPWTLNNWYKHVNWLNFVLVIAIPSYGLFQAFQYPPCLKTLVLAFVLYAFSGLSITAGYHRGWAHKAYEMSTPVKWFFALFGAGAIQGSVKWWAHGHRVHHRYTDTNKDPYDARKGFMYSHLTWMLTIPNPKHRARADISDLIADPVVKFQHTHYMALLLLMAFIVPTVTAGLFWGDYWGGFIYGGILKTFVIQQATFCVNSLAHWIGKQPFDDRRTPRDHALTALVTFGEGYHNFHHEFPSDYRNALKWYQYDPTKVTIYVLSKLGLAHNLRTFSQNAIDQGRFQQQQKMLDKMRTNLQWGQQVSELPVWDREEFNTRAKKEGLILISGIIHNVKTFIKEHPGGQAVVRASLGKDASEAFNGAVYAHSNAAHNLLANMRVAVLRDSNPNNNTFAVQQQYLDDHAIYKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWF6</accession>
    <name>G3AWF6_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Opaque-phase-specific protein OP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112249</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683786.1">
        <property type="nucleotide sequence ID" value="XM_006683723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWF6"/>
    <dbReference type="GeneID" id="18246425"/>
    <dbReference type="KEGG" id="cten:18246425"/>
    <dbReference type="eggNOG" id="ENOG502RPZ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676366_0_0_1"/>
    <dbReference type="OrthoDB" id="4093337at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442417" description="Opaque-phase-specific protein OP4" evidence="2">
        <location>
            <begin position="20"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="40869" checksum="314F18118E2228B3" modified="2011-11-16" version="1">MKLSTFCVPLLALTSFTNSQPLGTSTSTEVGLSKREYTILTEFFTAIEKTGVAPKLIKLLDGNKITEPILVKAIVAFLKTQDLTNLLVAVDKSGLAVDIFLRALQDSSFFPGLYTIIDGLKDGTSSATPTSSSLDTVGLVSEISTIASTYAEYAADGLSSILSTVADDLDIGSGTGIISYLDPIFNLVGLGSLADSDSGTEVTLNSAATAAASGVTVATSTGTTATGTKAATTTTTGTKAATGTTATGTTATGTKAATTTKATSTATSTSTSTSSSSTSGWLSSLFNTVSGWFDKRDFDDETADVLKKMVKKLAKRDNSILDNLVESLEKSGLAMQVVVGLIEDSANYPFVRDLIIKIVQDGVISIADLTTALNSSNLLNDAIIGALTSSDLGITIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWG0</accession>
    <name>G3AWG0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTEDRAFT_117516</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683788.1">
        <property type="nucleotide sequence ID" value="XM_006683725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWG0"/>
    <dbReference type="STRING" id="590646.G3AWG0"/>
    <dbReference type="GeneID" id="18248577"/>
    <dbReference type="KEGG" id="cten:18248577"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442680" description="Cytochrome P450" evidence="6">
        <location>
            <begin position="21"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EGV66530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="60565" checksum="A870E83D02E69F95" modified="2011-11-16" version="1">MPAALKCFLLVLLGIAVVLVLDKYDYLGGKSFPGIFQIPGHPLVGNILQVQKNPAKLFMEWANEYRQPIFQIRLGNKSVIVVNSFKDVSEIWKKTCVNSRPMQYTFHNLVSSTKEFTIGTTPFGKTFKKRKQVISQALNGKNTKLLVAVLDDETKYTIKMIFLSNPTLCFQPSTNPYIIHPDVNLIKNFQYFSLRTAVFITYGCKLDCYRHDKELADKIIKCENKIIKLRSPVSNILDFFPILRYIIPESATRESREERDFYMKTLYKNRSEKPSEHPNLIRDFYSLTNPKGIDFTELKTICLTMVSAGLDNTPLNLEHLFGQLSTHPLGSNFQEIAVGELLSLYQTPMNVWHKVVAECECSFIMALIQETLRYFTVLPLGLPRATTKSFQYQGIVVPEGATLIMNAFAANHDETHFLHPYTFDPYRWLDKGKLKHSDAISHFAFGKGIRMCSGNMFAFKEMYILVCRLLLCFKISSPRDKRLAMEKDPFKGNSNPRATSFDPKPFKYQLVPRKMYGNDDLFNYILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>G3AWL3</accession>
    <name>G3AWL3_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pet127-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_91731</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AWL3"/>
    <dbReference type="STRING" id="590646.G3AWL3"/>
    <dbReference type="GeneID" id="18250105"/>
    <dbReference type="KEGG" id="cten:18250105"/>
    <dbReference type="eggNOG" id="ENOG502QPU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438037_0_0_1"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="624" mass="71661" checksum="7578D1BD7A0ECFA3" modified="2011-11-16" version="1">MPKDLNKAIPSEAVDYLRKSSKLPKPKLKIVTKKIGSTGAIKQVVSLDKESIPRLTHGLEEVLKKNGVQYLYLTRERKYQFHKSFSNIDQLDDFKSLKSEITGKFVSPSKDEALLNLSRENDAKYYSSTSSMTSTLFQFYMLLNSFDTKNPSASRFKFGSFTNLMSSIPASTIVSKKDAENDIYSVEIDKSCDIDHFLSEFGHIAEIVLTNDSNDIKRFKDFYNRENDGIGSDTDQDPEHIQDLIKFEKFKNPENIYNISKYDKFLMRSQLDCYSPLLKENGTFDLKSRAISEIRYDMTNRSMRDTNYSNRFFYLDEMDDLIRTAGLLKYSFQARIGQMSGIFVAFHNIRQFLAFEYLSLEAIDKVFFDNSNIASYIANSQFKFSLRIWGQLLDMIKEDLNADHFRVVLKSETVEGQQFNAIKANVVALSQDQISQSHLIKEDFNRALKEASEKFKDNTEELASARKELLKSYKTALDDFNKSTISDRNIVSYTVETIQLLNDKRMDLHKLPTSTDDKWSLVYKIIRERPDPVLYLKHLSAMTKAVTKEFAYKSHVSSKSTSSNKPRSKSTNKTRSSQSDQGYSRPLKSKGYFPSDNRTGVKSPIQGNPNSPLNQTKTLLSNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>G3AX57</accession>
    <name>G3AX57_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTEDRAFT_117876</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AX57"/>
    <dbReference type="STRING" id="590646.G3AX57"/>
    <dbReference type="GeneID" id="18248606"/>
    <dbReference type="KEGG" id="cten:18248606"/>
    <dbReference type="eggNOG" id="ENOG502QUZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035846_0_0_1"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003442688" evidence="9">
        <location>
            <begin position="19"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EGV66694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="424" mass="43259" checksum="29C56BB800C36218" modified="2011-11-16" version="1">MQIKSFVALSALSAIALAANNSTLTTATPSVKSACKFDDFTATASADVASVAACATAVGDITIEGDEFGTIELTGVEAIYGNLHIQNATQASAFNAATLQLVSGELSLDANTILASLNLAQLTTVGSFSLTALPALEVIGLTSGITSAESVIISDTGLNTLEGINVVQLKTFNVNNNDQIQLIDSGLQKVTDTLSISFNADSVDVKLDQLSEAKDVYLQSISSFSAANLTKVTGSLSFVSNSIEKIEISSLKSVSNSLTVSKNSDLEEIEFANLTSIGGALVISENDDLSTFAGFPELAKVGGSVSINGSFDNGTFESLESVSGGFNLRSTGDLTCEEFNELNSDGDIKGDKYYCSGANTETSSSSSKSGNANGVSTSSADDEDSSSSSSSSDSTTTTKDSSASAPGGFIALLAGAAAIGLSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXC2</accession>
    <name>G3AXC2_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112083</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10573</strain>
            <strain evidence="4">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683992.1">
        <property type="nucleotide sequence ID" value="XM_006683929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXC2"/>
    <dbReference type="STRING" id="590646.G3AXC2"/>
    <dbReference type="GeneID" id="90982015"/>
    <dbReference type="KEGG" id="cten:90982015"/>
    <dbReference type="HOGENOM" id="CLU_083354_1_0_1"/>
    <dbReference type="OrthoDB" id="4018368at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833522" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="43"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EGV66733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="163" mass="17531" checksum="2E11893ADE5866AC" modified="2011-11-16" version="1">MKFSIVFASAAALMTVANAAPTPESTSVQKRSDPIVHLFVESEDSSVSGQGLSPLHEGAALDYVFLGKNSADFHYNSTSHSIYSLDGNLELVPVVESNIVEFVPGKPNVFVKDGYLSYKGSSSFAACNNVNQQYDYKGYALAQYPNENVPRGCINVKVKAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXF0</accession>
    <name>G3AXF0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTEDRAFT_128793</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXF0"/>
    <dbReference type="STRING" id="590646.G3AXF0"/>
    <dbReference type="eggNOG" id="KOG2090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_0_0_1"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="14">
        <location>
            <begin position="264"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EGV66360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="757" mass="87368" checksum="D8E2BE0FEE6A67CF" modified="2011-11-16" version="1">MKRSGTVVESCKRESKIWPDLLIENQRFYNDFNRKHKSTINVGLFTNEHLKDPKGLVQFSKDSLRDAKSLVAQMLADVKHGEEGRLTYIRKLDQLSDILCRVIDVAEFIRNAHPQQAWVEAAQKTHEILFEYMNQLNTNVDLYTNLVMVLNDEAIGAQLTDEEINVGEYLKQDFEKSGIHMDEKSRRNFVELTQEISVIGANYSNGLHNLESMWCDVDRGDFENISDANLKKEILSFQSRSPTFERGRTNVVSIPLMEHIPYYVLTNCSSEAIRRKVWIAYHNASKHQIGLLNGFIRYRAVLARMLGYESYAHHQLEYKMAKNPENVKAFLNKVQATLLDSKENRLMDEIRSLYAYKPNADMTLSDDEIIHEVKPWDRDYLLNKLQTDPRNSAVDSNEIKEYLSIGTVMSGLNQLFESIYQIQLIPEAVGKGETWEKGQVRKIRVFDTQNQITLGYLYIDFWSPKVFPSHFTIVCSRQLNTDIGIESKDEVKNQVHLDDSETYQLPVVSLVFNFHKSTSIFPFATGPSLLNLEQVETIFHEMGHAMHSMIGRTKLQNLSGTRAATDFVELPSVLMESFAKDPRVICKIAKHYKTGEPLDQEMFEKHQKQKVILYDSEIFMQSKMALLDQVLHNADTVALMVDNFDTFDTTPIYHKLESDLGIFADKWSTWHGKFLHLFSYGAVYYSYLLDRAIADKVYKELFYSDPWSLKAGNKYKESILKWGGTRDPWLCLADALDNERLKAGDFKAMEIIAADFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXF5</accession>
    <name>G3AXF5_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Vacuolar protein sorting protein 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTEDRAFT_112108</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXF5"/>
    <dbReference type="STRING" id="590646.G3AXF5"/>
    <dbReference type="eggNOG" id="KOG3232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080826_0_0_1"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EGV66365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="200" mass="22357" checksum="05304B369F2C675D" modified="2011-11-16" version="1">MAGLEQSLFQLKFTAKQLNKQASKAAKEELQEKAKVKKAMVQGNPDIAQLYAQNAIRKANERVNLLRLSSRIDAVASRVQTAVTMRSVTGNMTNVIRGMDKALQTMNLERISMVMEKFETQFEDLDASTNYYESATNNVSALTTPQEQVDDLMSQIADEAGIEMKQGLNETKVEINTPPTSVVTDEKEDKLAERLRALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXH2</accession>
    <name>G3AXH2_CANTC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTEDRAFT_91540</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Yamadazyma tenuis</name>
        <dbReference type="NCBI Taxonomy" id="590646"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Yamadazyma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="13212" last="13217">
            <title>Comparative genomics of xylose-fermenting fungi for enhanced biofuel production.</title>
            <authorList>
                <person name="Wohlbach D.J."/>
                <person name="Kuo A."/>
                <person name="Sato T.K."/>
                <person name="Potts K.M."/>
                <person name="Salamov A.A."/>
                <person name="LaButti K.M."/>
                <person name="Sun H."/>
                <person name="Clum A."/>
                <person name="Pangilinan J.L."/>
                <person name="Lindquist E.A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Jin M."/>
                <person name="Gunawan C."/>
                <person name="Balan V."/>
                <person name="Dale B.E."/>
                <person name="Jeffries T.W."/>
                <person name="Zinkel R."/>
                <person name="Barry K.W."/>
                <person name="Grigoriev I.V."/>
                <person name="Gasch A.P."/>
            </authorList>
            <dbReference type="PubMed" id="21788494"/>
            <dbReference type="DOI" id="10.1073/pnas.1103039108"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GL996510">
        <property type="protein sequence ID" value="EGV66378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_006683636.1">
        <property type="nucleotide sequence ID" value="XM_006683573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="G3AXH2"/>
    <dbReference type="STRING" id="590646.G3AXH2"/>
    <dbReference type="GeneID" id="18250084"/>
    <dbReference type="KEGG" id="cten:18250084"/>
    <dbReference type="eggNOG" id="ENOG502SGQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113787_1_0_1"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000000707">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EGV66378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000707"/>
        </source>
    </evidence>
    <sequence length="136" mass="15503" checksum="C540168816AC758C" modified="2011-11-16" version="1">MEHQDQNIINLKTISRLFHELAFNKENTRLSQKTLQLSAQYINLFIREGILRSNDERLSDGDRLSHVDGIDNLETIRGNEGEEVEEEVPDITLNEDDIQSNPNTQYTSNEPPADGDNDTLDVRHLSKIAGVLLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-11-16" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>G3AXM0</accession>
    <name>G3AXM0_CANTC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTEDRAFT_112521</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)</name>
        <name 
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